DK3293183T3 - Hæmmerforbindelser - Google Patents

Hæmmerforbindelser Download PDF

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Publication number
DK3293183T3
DK3293183T3 DK17192253.7T DK17192253T DK3293183T3 DK 3293183 T3 DK3293183 T3 DK 3293183T3 DK 17192253 T DK17192253 T DK 17192253T DK 3293183 T3 DK3293183 T3 DK 3293183T3
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DK
Denmark
Prior art keywords
relations
limiting
limiting relations
Prior art date
Application number
DK17192253.7T
Other languages
English (en)
Inventor
Swen Hoelder
Julian Blagg
Savade Solanki
Hannah Woodward
Sebastien Naud
Vassilios Bavetsias
Peter Sheldrake
Paolo Innocenti
Kwai-Ming J Cheung
Butrus Atrash
Original Assignee
Cancer Research Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Tech Ltd filed Critical Cancer Research Tech Ltd
Application granted granted Critical
Publication of DK3293183T3 publication Critical patent/DK3293183T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK17192253.7T 2012-09-07 2013-09-09 Hæmmerforbindelser DK3293183T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1216017.2A GB201216017D0 (en) 2012-09-07 2012-09-07 Inhibitor compounds
EP13760106.8A EP2892889B1 (en) 2012-09-07 2013-09-09 Inhibitor compounds

Publications (1)

Publication Number Publication Date
DK3293183T3 true DK3293183T3 (da) 2019-08-12

Family

ID=47137117

Family Applications (2)

Application Number Title Priority Date Filing Date
DK17192253.7T DK3293183T3 (da) 2012-09-07 2013-09-09 Hæmmerforbindelser
DK13760106.8T DK2892889T3 (da) 2012-09-07 2013-09-09 Hæmmerforbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK13760106.8T DK2892889T3 (da) 2012-09-07 2013-09-09 Hæmmerforbindelser

Country Status (22)

Country Link
US (6) US9409907B2 (da)
EP (2) EP3293183B1 (da)
JP (2) JP6216791B2 (da)
CN (1) CN104837829B (da)
AU (2) AU2013311434B2 (da)
BR (1) BR112015004489B1 (da)
CA (1) CA2884006C (da)
CY (1) CY1119714T1 (da)
DK (2) DK3293183T3 (da)
ES (2) ES2655194T3 (da)
GB (1) GB201216017D0 (da)
HK (1) HK1211921A1 (da)
HR (1) HRP20171835T1 (da)
HU (1) HUE036259T2 (da)
LT (1) LT2892889T (da)
NO (1) NO2892889T3 (da)
PL (1) PL2892889T3 (da)
PT (1) PT2892889T (da)
RS (1) RS56750B1 (da)
RU (1) RU2673079C2 (da)
SI (1) SI2892889T1 (da)
WO (1) WO2014037750A1 (da)

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CN109851617B (zh) 2013-08-23 2022-08-16 润新生物公司 化学实体、组合物和方法
GB201403536D0 (en) 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
JP6616934B2 (ja) * 2014-05-22 2019-12-04 株式会社 資生堂 レナリドミドの光学分割方法
EP3270694A4 (en) * 2015-02-17 2018-09-05 Neupharma, Inc. Certain chemical entities, compositions, and methods
CN107567503B (zh) 2015-04-17 2022-03-22 荷兰转化研究中心有限责任公司 用于ttk抑制剂化疗的预后生物标记
PL3305785T3 (pl) 2015-05-29 2021-12-27 Teijin Pharma Limited Pochodna pirydo[3,4-d]pirymidyny i jej farmaceutycznie dopuszczalna sól
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Also Published As

Publication number Publication date
ES2742442T3 (es) 2020-02-14
CA2884006A1 (en) 2014-03-13
RU2673079C2 (ru) 2018-11-22
US20160222009A1 (en) 2016-08-04
GB201216017D0 (en) 2012-10-24
JP2018027967A (ja) 2018-02-22
US9409907B2 (en) 2016-08-09
US11897877B2 (en) 2024-02-13
AU2013311434B2 (en) 2017-10-19
PL2892889T3 (pl) 2018-03-30
RU2015112580A (ru) 2016-10-27
SI2892889T1 (sl) 2017-12-29
JP2015527387A (ja) 2015-09-17
US9834552B2 (en) 2017-12-05
US20150239884A1 (en) 2015-08-27
EP3293183A1 (en) 2018-03-14
CY1119714T1 (el) 2018-06-27
BR112015004489B1 (pt) 2020-09-29
EP2892889A1 (en) 2015-07-15
HRP20171835T1 (hr) 2017-12-29
HUE036259T2 (hu) 2018-06-28
WO2014037750A1 (en) 2014-03-13
JP6216791B2 (ja) 2017-10-18
US20160220570A1 (en) 2016-08-04
RS56750B1 (sr) 2018-03-30
PT2892889T (pt) 2018-01-09
NO2892889T3 (da) 2018-03-17
EP2892889B1 (en) 2017-10-18
HK1211921A1 (en) 2016-06-03
US10479788B2 (en) 2019-11-19
US11046688B2 (en) 2021-06-29
AU2017268488A1 (en) 2017-12-14
BR112015004489A2 (pt) 2017-07-04
JP6496376B2 (ja) 2019-04-03
CN104837829A (zh) 2015-08-12
CA2884006C (en) 2021-01-19
DK2892889T3 (da) 2017-12-11
EP3293183B1 (en) 2019-07-24
US20180141944A1 (en) 2018-05-24
AU2017268488B2 (en) 2019-06-13
US20220402912A1 (en) 2022-12-22
ES2655194T3 (es) 2018-02-19
US9890157B2 (en) 2018-02-13
AU2013311434A1 (en) 2015-04-02
LT2892889T (lt) 2017-12-11
CN104837829B (zh) 2019-07-05
US20200165241A1 (en) 2020-05-28

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