AP1703A - Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same. - Google Patents

Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same.

Info

Publication number
AP1703A
AP1703A APAP/P/2003/002744A AP2003002744A AP1703A AP 1703 A AP1703 A AP 1703A AP 2003002744 A AP2003002744 A AP 2003002744A AP 1703 A AP1703 A AP 1703A
Authority
AP
ARIPO
Prior art keywords
heparin
preparation
pharmaceutical compositions
compositions containing
containing same
Prior art date
Application number
APAP/P/2003/002744A
Other versions
AP2003002744A0 (en
Inventor
Jacques Diaz
Christelle Pecquet
Elisabeth Perrin
Christian Viskov
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8852768&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP1703(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AP2003002744A0 publication Critical patent/AP2003002744A0/en
Application granted granted Critical
Publication of AP1703A publication Critical patent/AP1703A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Abstract

The invention concerns heparin-derived polysaccharide mixtures, their preparation method and pharmaceutical compositions containing them.
APAP/P/2003/002744A 2000-07-21 2001-07-18 Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same. AP1703A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0009572A FR2811992B1 (en) 2000-07-21 2000-07-21 MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR2001/002332 WO2002008295A1 (en) 2000-07-21 2001-07-18 Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same

Publications (2)

Publication Number Publication Date
AP2003002744A0 AP2003002744A0 (en) 2003-03-31
AP1703A true AP1703A (en) 2007-02-26

Family

ID=8852768

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2003/002744A AP1703A (en) 2000-07-21 2001-07-18 Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same.

Country Status (36)

Country Link
EP (1) EP1307491B2 (en)
JP (1) JP5279160B2 (en)
KR (1) KR100853585B1 (en)
CN (1) CN1230449C (en)
AP (1) AP1703A (en)
AR (1) AR029865A1 (en)
AT (1) ATE470679T1 (en)
AU (2) AU2001277602B2 (en)
BR (1) BR0112612B1 (en)
CA (1) CA2416673C (en)
CL (1) CL2004001154A1 (en)
CY (1) CY1110774T1 (en)
DE (1) DE60142340D1 (en)
DK (1) DK1307491T3 (en)
DZ (1) DZ3411A1 (en)
EA (1) EA005995B1 (en)
EC (1) ECSP034442A (en)
ES (1) ES2347134T5 (en)
FR (1) FR2811992B1 (en)
HK (1) HK1059273A1 (en)
HR (1) HRP20030019A2 (en)
HU (1) HUP0300755A3 (en)
IL (2) IL153922A0 (en)
MA (1) MA26928A1 (en)
MX (1) MXPA03000579A (en)
NO (1) NO20030296L (en)
NZ (1) NZ524028A (en)
OA (1) OA12340A (en)
PL (1) PL202471B1 (en)
PT (1) PT1307491E (en)
SI (1) SI1307491T1 (en)
TW (1) TWI307278B (en)
UA (1) UA74836C2 (en)
WO (1) WO2002008295A1 (en)
YU (1) YU2903A (en)
ZA (1) ZA200300898B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
DE60218642T2 (en) * 2002-06-20 2007-11-29 Chemi S.P.A., Cinisello Balsamo Process for the preparation of heparin esters
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
AR041555A1 (en) 2002-10-10 2005-05-18 Aventis Pharma Sa MIXTURES OF POLYACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2845686B1 (en) * 2002-10-10 2013-08-30 Aventis Pharma Sa MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US7956046B2 (en) * 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
FR2857971B1 (en) * 2003-07-24 2005-08-26 Aventis Pharma Sa MIXTURES OF HEPARIN DERIVED OLIGOSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE102004059134B4 (en) 2004-12-08 2011-12-15 Siemens Ag Expansion device for an X-ray machine and X-ray source
WO2007140231A2 (en) * 2006-05-25 2007-12-06 Momenta Pharmaceutical, Inc. Low molecular weight heparin composition and uses thereof
CN101824099B (en) * 2010-02-12 2011-11-30 淮安麦德森化学有限公司 Method for purifying crude product heparin sodium
CN101824446B (en) * 2010-02-24 2012-12-12 淮安麦德森化学有限公司 Method for producing chondroitin sulfate by reverse precipitation
EP2399592A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings
EP2399590A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopaedic surgery
EP2399591A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for the extended prevention of a mortality and/or morbidity event in a patient having undergone hip fracture surgery
EP2399593A1 (en) 2010-06-28 2011-12-28 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in orthopaedic surgery with improved benefit-risk profile
CN102399379B (en) * 2010-09-09 2016-08-31 上海喜恩医药科技发展有限公司 Polysaccharide mixture of a kind of heparin derivative and preparation method thereof and pharmaceutical composition
EP3144325B1 (en) * 2010-09-14 2020-11-04 University Of Miyazaki High purity heparin and production method therefor
EP2446891A1 (en) 2010-10-28 2012-05-02 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in major abdominal surgery with improved safety in terms of clinically relevant bleedings and major bleedings
WO2012055843A1 (en) 2010-10-28 2012-05-03 Aventis Pharma S.A. Semuloparin for the prevention of major venous thromboembolism in a patient undergoing major abdominal surgery
EP2548561A1 (en) 2011-07-22 2013-01-23 Aventis Pharma S.A. Semuloparin for improving the survival of patients with locally advanced cancer
ES2445494B1 (en) * 2012-08-02 2015-03-06 Rovi Lab Farmaceut Sa Procedure for obtaining low and very low molecular weight heparins
CN103175925B (en) * 2013-03-20 2014-12-03 山东辰中生物制药有限公司 Method for detecting esterification rate of heparin benzyl ester in production process of enoxaparin sodium
FR3016632A1 (en) * 2014-01-21 2015-07-24 IFP Energies Nouvelles PROCESS FOR TRANSFORMING POLYSACCHARIDES TO OXYGENIC MOLECULES IN THE PRESENCE OF NEUTRAL ORGANIC SUPERBASES
CZ306662B6 (en) * 2015-06-26 2017-04-26 Contipro A.S. Sulphated polysaccharides derivatives, the method of their preparation, the method of their modification and the use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027089A1 (en) * 1979-10-05 1981-04-15 Choay S.A. Oligosaccharide fractions and oligosaccharides with biological properties, process for their preparation and their uses as medicines
EP0040144A1 (en) * 1980-05-14 1981-11-18 Pharmuka Laboratoires Sulfated polysaccharides, process for their preparation and their use as medicines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2478646A2 (en) * 1980-03-20 1981-09-25 Choay Sa MUCOPOLYSACCHARIDIC COMPOSITION HAVING A COAGULATION REGULATING ACTIVITY, MEDICAMENT CONTAINING THE SAME, AND METHOD FOR OBTAINING THE SAME
US4916219A (en) * 1985-03-28 1990-04-10 University Of Iowa Research Foundation Oligosaccharide heparin fragments as inhibitors of complement cascade
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
ES2077533B1 (en) * 1994-02-28 1996-07-01 Bioiberica PROCEDURE FOR OBTAINING OLIGOSACCHARIDE FRACTIONS BY CHEMICAL DEPOLYMERIZATION OF HEPARIN.
JP4897991B2 (en) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ Ultra low molecular weight heparin composition
ES2161615B1 (en) * 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa COMPOSITIONS OF HEPARINS OF VERY LOW MOLECULAR WEIGHT.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027089A1 (en) * 1979-10-05 1981-04-15 Choay S.A. Oligosaccharide fractions and oligosaccharides with biological properties, process for their preparation and their uses as medicines
EP0040144A1 (en) * 1980-05-14 1981-11-18 Pharmuka Laboratoires Sulfated polysaccharides, process for their preparation and their use as medicines

Also Published As

Publication number Publication date
NO20030296D0 (en) 2003-01-20
HUP0300755A2 (en) 2003-12-29
CN1447820A (en) 2003-10-08
MA26928A1 (en) 2004-12-20
MXPA03000579A (en) 2003-06-06
DE60142340D1 (en) 2010-07-22
BR0112612B1 (en) 2011-07-12
CA2416673C (en) 2011-06-14
ECSP034442A (en) 2003-03-10
PT1307491E (en) 2010-09-10
ES2347134T5 (en) 2014-06-24
NZ524028A (en) 2004-12-24
EP1307491B2 (en) 2014-05-07
BR0112612A (en) 2003-07-29
HK1059273A1 (en) 2004-06-25
HUP0300755A3 (en) 2004-03-01
AR029865A1 (en) 2003-07-16
CN1230449C (en) 2005-12-07
PL365561A1 (en) 2005-01-10
ZA200300898B (en) 2004-04-30
ATE470679T1 (en) 2010-06-15
ES2347134T3 (en) 2010-10-26
DZ3411A1 (en) 2002-01-31
NO20030296L (en) 2003-01-20
SI1307491T1 (en) 2010-10-29
EP1307491A1 (en) 2003-05-07
UA74836C2 (en) 2006-02-15
HRP20030019A2 (en) 2005-10-31
EP1307491B1 (en) 2010-06-09
EA005995B1 (en) 2005-08-25
CY1110774T1 (en) 2015-06-10
AU7760201A (en) 2002-02-05
AU2001277602B2 (en) 2007-07-19
DK1307491T3 (en) 2010-10-11
KR100853585B1 (en) 2008-08-21
CA2416673A1 (en) 2002-01-31
JP5279160B2 (en) 2013-09-04
KR20030040364A (en) 2003-05-22
TWI307278B (en) 2009-03-11
JP2004504451A (en) 2004-02-12
PL202471B1 (en) 2009-06-30
FR2811992B1 (en) 2003-07-04
OA12340A (en) 2006-05-15
FR2811992A1 (en) 2002-01-25
EA200300178A1 (en) 2003-06-26
AP2003002744A0 (en) 2003-03-31
CL2004001154A1 (en) 2005-05-27
IL153922A0 (en) 2003-07-31
WO2002008295A1 (en) 2002-01-31
IL153922A (en) 2010-05-17
YU2903A (en) 2006-03-03

Similar Documents

Publication Publication Date Title
AP1703A (en) Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same.
DE69905170D1 (en) Thiazolopyrimidinderivate
ZA200206905B (en) Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same.
AP2001002225A0 (en) 1-heterocycle substituted diarylamines.
WO1999054286A3 (en) Btk inhibitors and methods for their identification and use
ATE289640T1 (en) AMIDOFUNCTIONAL AMINOPOLYDIORGANOSILOXANES
HUP0204514A3 (en) Pyridinylimidazoles, pharmaceutical compositions containing them and their use
CY1112687T1 (en) METHOD FOR USING DICTIONARIES AND COMPOSITIONS THAT INCLUDE
HUP0200312A3 (en) Substituted 2-phenylbenzimidazoles, pharmaceutical compositions containing them, the production thereof and their use
HUP0301573A3 (en) Substituted arylpyrazines, pharmaceutical compositions containing them and their use
HK1047584A1 (en) Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process.
AU2001277602A1 (en) Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
HUP0401638A3 (en) Thiopene-amides, thiazolesulfonamides as antineoplastic agents, and pharmaceutical composition containing the same
HUP0400967A3 (en) Substituted 2-anilino-benzimidazoles, their use and pharmaceutical compositions containing them
HUP0102215A3 (en) Benzoylpyridazines, pharmaceutical compositions containing the same and process for their preparation
ZA99355B (en) Synthetic polysaccharides, process for their preparation and pharmaceutical compositions containing them.
AU5892399A (en) 1, 2, 4-triazole-3-thione compounds
HUP0302515A3 (en) Sulfanidothienopyrimidines, process for their preparation and pharmaceutical compositions containing them
HK1060129A1 (en) Novel piperidinecarboxamide derivatives, method f or preparing same and pharmaceutical compositions containing same.
IL139531A0 (en) Human antithrombin iii, methods for the production thereof and pharmaceutical compositions containing the same
IL128500A (en) SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA[b] BENZOFURANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BR9916537B1 (en) fragrance composition, and, product.
HK1052168A1 (en) N-deacetylthiocolchincine derivatives and pharmaceutical compositions containing them.
ZA200002546B (en) Sorbate-preserved compositions, method for the manufacture thereof and their use.
HUP0103006A3 (en) Substituted betha-diketones, pharmaceutical compositions containing them and their use