AR041555A1 - MIXTURES OF POLYACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

MIXTURES OF POLYACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
AR041555A1
AR041555A1 ARP030103661A ARP030103661A AR041555A1 AR 041555 A1 AR041555 A1 AR 041555A1 AR P030103661 A ARP030103661 A AR P030103661A AR P030103661 A ARP030103661 A AR P030103661A AR 041555 A1 AR041555 A1 AR 041555A1
Authority
AR
Argentina
Prior art keywords
mixtures
preparation
pharmaceutical compositions
compositions containing
derived
Prior art date
Application number
ARP030103661A
Other languages
Spanish (es)
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0212584A external-priority patent/FR2845686B1/en
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AR041555A1 publication Critical patent/AR041555A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Se refiere a mezclas de polisacáridos derivados de heparina que tiene un peso molecular medio de 1500 a3000 Daltons y una relación AntiXA/Anti-Ilia superior a 30, el procedimiento para su preparación y las composiciones farmacéuticas que las contienen. Reivindicación 1: Mezclas de oligosacáridos sulfatados que poseen la estructura general de los polisacáridos constitutivos de la heparina y que presenta las siguientes características: tienen un peso molecular medio de 1500 a 3000 daltons, una actividad anti-Xa de 120 a 200 UI/mg, una actividad anti-IIa de inferior a 10 UI/mg y una relación de actividad anti-Xa/actividad anti-IIa superior a 30 los oligosacáridos constitutivos de las mezclas contienen 2 a 26 restos sacáridos, tienen un resto ácido 4,5-urónico insaturado 2-0-sulfato en uno de los extremos, contienen el hexasacárido delta IIa-IIs-Is de fórmula 1 y están bajo forma de una sal de metal alcalino o alcalinotérreo.It refers to mixtures of heparin-derived polysaccharides having an average molecular weight of 1500-3000 Daltons and an AntiXA / Anti-Ilia ratio greater than 30, the process for their preparation and the pharmaceutical compositions containing them. Claim 1: Mixtures of sulfated oligosaccharides having the general structure of the constituent polysaccharides of heparin and having the following characteristics: they have an average molecular weight of 1500 to 3000 daltons, an anti-Xa activity of 120 to 200 IU / mg, an anti-IIa activity of less than 10 IU / mg and an anti-Xa / anti-IIa activity ratio greater than 30 the oligosaccharides constituting the mixtures contain 2 to 26 saccharide moieties, have a 4,5-uronic acid moiety unsaturated 2-0-sulfate at one end, they contain the hexasaccharide delta IIa-IIs-Is of formula 1 and are in the form of an alkali metal or alkaline earth metal salt.

ARP030103661A 2002-10-10 2003-10-08 MIXTURES OF POLYACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AR041555A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0212584A FR2845686B1 (en) 2002-10-10 2002-10-10 MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR2003/002960 WO2004033503A1 (en) 2002-10-10 2003-10-08 Heparin-derived polysaccharide mixtures, preparation thereof and pharmaceutical compositions containing same

Publications (1)

Publication Number Publication Date
AR041555A1 true AR041555A1 (en) 2005-05-18

Family

ID=45907990

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030103661A AR041555A1 (en) 2002-10-10 2003-10-08 MIXTURES OF POLYACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (2)

Country Link
KR (1) KR101104107B1 (en)
AR (1) AR041555A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
ES2161615B1 (en) 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa COMPOSITIONS OF HEPARINS OF VERY LOW MOLECULAR WEIGHT.
FR2811992B1 (en) 2000-07-21 2003-07-04 Aventis Pharma Sa MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
KR101104107B1 (en) 2012-01-12
KR20050061527A (en) 2005-06-22

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal
FG Grant, registration
FG Grant, registration