DE69730971D1 - Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten - Google Patents

Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten

Info

Publication number
DE69730971D1
DE69730971D1 DE69730971T DE69730971T DE69730971D1 DE 69730971 D1 DE69730971 D1 DE 69730971D1 DE 69730971 T DE69730971 T DE 69730971T DE 69730971 T DE69730971 T DE 69730971T DE 69730971 D1 DE69730971 D1 DE 69730971D1
Authority
DE
Germany
Prior art keywords
improving
detection
transdermal administration
medicinal products
body liquids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69730971T
Other languages
English (en)
Other versions
DE69730971T2 (de
Inventor
J Cormier
P Neukermans
Barry Block
S Nat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of DE69730971D1 publication Critical patent/DE69730971D1/de
Application granted granted Critical
Publication of DE69730971T2 publication Critical patent/DE69730971T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A61B5/150427—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15105—Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism
    • A61B5/15113—Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
DE69730971T 1996-06-18 1997-06-18 Vorrichtung für die transdermale verabrecihung von medikamenten oder der abnahme von körperflüssigkeiten Expired - Lifetime DE69730971T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1999096P 1996-06-18 1996-06-18
US19990P 1996-06-18
PCT/US1997/010596 WO1997048442A1 (en) 1996-06-18 1997-06-18 Device for enhancing transdermal agent delivery or sampling

Publications (2)

Publication Number Publication Date
DE69730971D1 true DE69730971D1 (de) 2004-11-04
DE69730971T2 DE69730971T2 (de) 2005-11-17

Family

ID=21796163

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69719761T Expired - Lifetime DE69719761T2 (de) 1996-06-18 1997-06-17 Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
DE69730971T Expired - Lifetime DE69730971T2 (de) 1996-06-18 1997-06-18 Vorrichtung für die transdermale verabrecihung von medikamenten oder der abnahme von körperflüssigkeiten
DE69730973T Expired - Fee Related DE69730973T2 (de) 1996-06-18 1997-06-18 Vorrichtung zur verbesserung der transdermalen abnahme von körperflüssigkeiten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69719761T Expired - Lifetime DE69719761T2 (de) 1996-06-18 1997-06-17 Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69730973T Expired - Fee Related DE69730973T2 (de) 1996-06-18 1997-06-18 Vorrichtung zur verbesserung der transdermalen abnahme von körperflüssigkeiten

Country Status (14)

Country Link
US (5) US6219574B1 (de)
EP (3) EP0914178B1 (de)
JP (4) JP4012252B2 (de)
AR (2) AR008242A1 (de)
AT (3) ATE234129T1 (de)
AU (3) AU3399197A (de)
CA (3) CA2253549C (de)
DE (3) DE69719761T2 (de)
DK (3) DK0914178T3 (de)
ES (3) ES2195151T3 (de)
PT (2) PT917483E (de)
TW (1) TW349872B (de)
WO (3) WO1997048440A1 (de)
ZA (1) ZA975326B (de)

Families Citing this family (738)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593852A (en) 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
JPH04278450A (ja) 1991-03-04 1992-10-05 Adam Heller バイオセンサー及び分析物を分析する方法
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
ATE234129T1 (de) * 1996-06-18 2003-03-15 Alza Corp Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
US6607509B2 (en) * 1997-12-31 2003-08-19 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
CN1170603C (zh) 1997-12-11 2004-10-13 阿尔扎有限公司 增强透皮物剂流量的装置
WO1999029364A1 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
DK1037687T3 (da) 1997-12-11 2009-01-26 Alza Corp Anordning til at forbedre et middels transdermale strömning
EP1911488A3 (de) 1997-12-11 2008-12-03 Alza Corporation Vorrichtung zur Verstärkung des Flusses transdermaler Mittel
JP4368060B2 (ja) * 1998-02-17 2009-11-18 アボット・ラボラトリーズ 間質流体の収集及びモニタリングデバイス
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6757560B1 (en) * 1999-04-09 2004-06-29 Novosis Pharma Ag Transdermal delivery system (TDS) with electrode network
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) * 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
DE69910003T2 (de) * 1998-05-13 2004-04-22 Cygnus, Inc., Redwood City Überwachung physiologischer analyte
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6355021B1 (en) * 1998-07-14 2002-03-12 Maersk Medical A/S Medical puncturing device
CA2338203A1 (en) * 1998-07-21 2000-02-03 Spectrx, Inc. System and method for continuous analyte monitoring
DE69921489T2 (de) * 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
US6148232A (en) * 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
JP4499295B2 (ja) * 1999-01-28 2010-07-07 サイト パルス サイエンシズ、インコーポレイテッド 細胞内への巨大分子の送達
DE19903876B4 (de) * 1999-02-01 2006-09-28 Orthogen Gentechnologie Gmbh Verfahren zur in-vitro-Bildung und Anreicherung von Interleukin-1 Rezeptor-Antagonisten
US6792306B2 (en) * 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US6856821B2 (en) * 2000-05-26 2005-02-15 Kci Licensing, Inc. System for combined transcutaneous blood gas monitoring and vacuum assisted wound closure
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US6251083B1 (en) 1999-09-07 2001-06-26 Amira Medical Interstitial fluid methods and devices for determination of an analyte in the body
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
ES2253278T3 (es) 1999-12-10 2006-06-01 Alza Corporation Dispositivo y procedimiento para mejorar la perforacion cutanea con microprotuberancias.
AU2088301A (en) * 1999-12-16 2001-06-25 Alza Corporation Device for enhancing transdermal flux of sampled agents
US7013179B2 (en) 2000-01-07 2006-03-14 Biowave Corporation Percutaneous electrode array
US20080033492A1 (en) * 2000-01-07 2008-02-07 Biowave Corporation Electro-therapy method
US20040054393A1 (en) * 2000-01-21 2004-03-18 Goran Stemme Medical electrode
US6622035B1 (en) * 2000-01-21 2003-09-16 Instrumentarium Corp. Electrode for measurement of weak bioelectrical signals
EP1225831A2 (de) * 2000-03-17 2002-07-31 Sontra Medical, Inc. Nichtinvasive körperflussentnahme und -analyse
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6607513B1 (en) 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US9717451B2 (en) 2000-06-08 2017-08-01 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
AU8346901A (en) 2000-08-24 2002-03-04 Alza Corp Method for transdermal nucleic acid sampling
US6690959B2 (en) 2000-09-01 2004-02-10 Medtronic, Inc. Skin-mounted electrodes with nano spikes
CA2422200A1 (en) * 2000-09-08 2002-03-14 Alza Corporation Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
AU2002210881A1 (en) 2000-10-12 2002-04-22 Ink Jet Technology Ltd. Transdermal method
AU9682701A (en) 2000-10-13 2002-04-22 Alza Corp Microblade array impact applicator
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
KR20030068137A (ko) 2000-10-13 2003-08-19 알자 코포레이션 충격 어플리케이터용 미세 돌기 부재 리테이너
MXPA03003299A (es) * 2000-10-13 2004-12-13 Johnson & Johnson Aparato y metodo para perforacion de la piel con microsalientes.
US7828827B2 (en) * 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
PT2266603E (pt) 2000-10-18 2012-11-02 Glaxosmithkline Biolog Sa Vacinas tumorais
EP2085109A3 (de) * 2000-10-26 2009-09-02 Alza Corporation Transdermale Arzneimittelverabreichungsvorrichtungen mit beschichteten Mikrovorsprüngen
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
DE10057832C1 (de) * 2000-11-21 2002-02-21 Hartmann Paul Ag Blutanalysegerät
US6591133B1 (en) * 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
WO2002074173A1 (en) 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
US6932933B2 (en) * 2001-03-30 2005-08-23 The Aerospace Corporation Ultraviolet method of embedding structures in photocerams
EP1397068A2 (de) 2001-04-02 2004-03-17 Therasense, Inc. Gerät und verfahren zur blutzuckerverfolgung
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
JP2004528900A (ja) * 2001-04-20 2004-09-24 アルザ・コーポレーシヨン 有益な作用物質を含有するコーティングを有する微小突起アレイ
EP1752189A3 (de) 2001-04-20 2007-02-21 Alza Corporation Mikroprojektionsanordnung mit einem Überzug, der ein vorteilhaftes Mittel enthält
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
WO2002100476A2 (en) 2001-06-08 2002-12-19 Becton, Dickinson And Company Device for manipulating a needle or abrader array
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US9795747B2 (en) * 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
WO2002100460A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Electric lancet actuator
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
AU2002314489A1 (en) * 2001-06-20 2003-01-02 Power Paper Ltd. Adhesive bandage with display
US8016773B2 (en) * 2001-07-19 2011-09-13 Arkray, Inc. Lancing apparatus
US20030028087A1 (en) * 2001-08-01 2003-02-06 Yuzhakov Vadim Vladimirovich Devices for analyte concentration determination and methods of using the same
SE0102736D0 (sv) * 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
EP1432466B1 (de) 2001-09-12 2012-08-15 Becton, Dickinson and Company Injektorvorrichtung auf mikronadelbasis zur arzneimittelabgabe und verwendungsverfahren dafür
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US8361037B2 (en) * 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20070179717A1 (en) * 2001-09-21 2007-08-02 Milliken Gordon L System and method for management of specimens
US6830562B2 (en) * 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
WO2003026733A2 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Microneedle with membrane
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US20030069482A1 (en) * 2001-10-09 2003-04-10 Workman Jerome James Sampling article for determining quantitative and qualitative drug transfer to skin
US6966880B2 (en) * 2001-10-16 2005-11-22 Agilent Technologies, Inc. Universal diagnostic platform
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US20040002121A1 (en) * 2001-11-06 2004-01-01 Regan Jeffrey F. High throughput methods and devices for assaying analytes in a fluid sample
EP2319577B1 (de) * 2001-11-07 2017-03-15 Syneron Medical Ltd. Integriertes System zur transdermalen Verabreichung von medikamenten
AU2002352978A1 (en) * 2001-11-30 2003-06-17 Alza Corporation Methods and apparatuses for forming microprojection arrays
RU2314760C2 (ru) * 2001-12-20 2008-01-20 Алза Корпорейшн Микровыступы, пробивающие кожу, имеющие средство регулирования глубины пробивки
ITTO20011228A1 (it) * 2001-12-28 2003-06-28 Cane Srl Contenitore per ago monouso.
US20040073175A1 (en) * 2002-01-07 2004-04-15 Jacobson James D. Infusion system
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
DE60328361D1 (de) 2002-02-04 2009-08-27 Becton Dickinson Co Vorrichtung und verfahren zur abgabe oder entnahme einer substanz durch die haut
US7004928B2 (en) * 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
DE60304681T2 (de) * 2002-02-12 2007-01-25 Unomedical A/S Infusionsvorrichtung mit nadelschutzhülse
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
WO2003101507A2 (en) * 2002-03-11 2003-12-11 Altea Therapeutics Corporation Transdermal drug delivery device, method and use
US8116860B2 (en) * 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
BR0311443A (pt) 2002-05-06 2005-03-22 Becton Dickinson Co Método e dispositivo para controlar farmacocinética de droga
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
US7060192B2 (en) * 2002-05-09 2006-06-13 Lifescan, Inc. Methods of fabricating physiological sample collection devices
US20030212344A1 (en) * 2002-05-09 2003-11-13 Vadim Yuzhakov Physiological sample collection devices and methods of using the same
US20030143113A2 (en) * 2002-05-09 2003-07-31 Lifescan, Inc. Physiological sample collection devices and methods of using the same
US20030211619A1 (en) * 2002-05-09 2003-11-13 Lorin Olson Continuous strip of fluid sampling and testing devices and methods of making, packaging and using the same
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
KR101323980B1 (ko) * 2002-07-19 2013-10-30 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법
AR040819A1 (es) * 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
ES2617576T3 (es) 2002-08-29 2017-06-19 Becton, Dickinson And Company Administración de sustancias mediante un sistema microabrasivo giratorio
DK1556124T3 (da) * 2002-09-02 2008-02-18 Unomedical As Apparatur og fremgangsmåde til justering af en infusionsslanges længde
DK1554008T3 (da) * 2002-09-02 2009-05-04 Unomedical As Indretning til subkutan tilförsel af et medikament til en patient
US20040051019A1 (en) * 2002-09-02 2004-03-18 Mogensen Lasse Wesseltoft Apparatus for and a method of adjusting the length of an infusion tube
DE60325607D1 (de) * 2002-09-02 2009-02-12 Unomedical As Gerät zur subkutanen verabreichung von medikamenten an einem patienten und zugehöriges rohr
US20120296233A9 (en) * 2002-09-05 2012-11-22 Freeman Dominique M Methods and apparatus for an analyte detecting device
AU2003275311A1 (en) * 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
US20040236269A1 (en) 2002-09-25 2004-11-25 Marchitto Kevin S. Microsurgical tissue treatment system
US20040115167A1 (en) * 2002-09-30 2004-06-17 Michel Cormier Drug delivery device and method having coated microprojections incorporating vasoconstrictors
US7244394B2 (en) * 2002-10-03 2007-07-17 Novartis Ag Methods and kits for assays of analytes of interest in tears
US20040106904A1 (en) 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
JP4599296B2 (ja) 2002-10-11 2010-12-15 ベクトン・ディキンソン・アンド・カンパニー 単一針または多針皮内（ｉｄ）送達装置に結合されたフィードバックまたはモデルベースコントローラを使用して患者の体内の物質の濃度の連続長期制御を開始し維持するためのシステムおよび方法
US7381184B2 (en) 2002-11-05 2008-06-03 Abbott Diabetes Care Inc. Sensor inserter assembly
US7045069B2 (en) * 2002-11-14 2006-05-16 Gennady Ozeryansky Microfabrication method based on metal matrix composite technology
DK200201823A (da) 2002-11-26 2004-05-27 Maersk Medical As Forbindelsesstykke for en slangeforbindelse
US7018345B2 (en) * 2002-12-06 2006-03-28 Hisamitsu Pharmaceutical Co., Inc. Iontophoresis system
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7811231B2 (en) 2002-12-31 2010-10-12 Abbott Diabetes Care Inc. Continuous glucose monitoring system and methods of use
US8771183B2 (en) 2004-02-17 2014-07-08 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
US20040158202A1 (en) * 2003-02-12 2004-08-12 Soren Jensen Cover
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US20050070819A1 (en) * 2003-03-31 2005-03-31 Rosedale Medical, Inc. Body fluid sampling constructions and techniques
US7070580B2 (en) * 2003-04-01 2006-07-04 Unomedical A/S Infusion device and an adhesive sheet material and a release liner
US20040265351A1 (en) * 2003-04-10 2004-12-30 Miller Richard L. Methods and compositions for enhancing immune response
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
JP2004343275A (ja) * 2003-05-14 2004-12-02 Murata Mach Ltd 画像処理システム及びスキャナ装置
ES2347248T3 (es) 2003-05-30 2010-10-27 Pelikan Technologies Inc. Procedimiento y aparato para la inyeccion de fluido.
DK1633235T3 (da) 2003-06-06 2014-08-18 Sanofi Aventis Deutschland Apparat til udtagelse af legemsvæskeprøver og detektering af analyt
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
AU2004255218A1 (en) 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
TW200513280A (en) * 2003-07-02 2005-04-16 Alza Corp Microprojection array immunization patch and method
US7888546B2 (en) * 2003-07-03 2011-02-15 Corium International, Inc. Wound dressing, ingredient delivery device and IV hold-down, and method relating to same
US7695239B2 (en) * 2003-07-14 2010-04-13 Fortrend Engineering Corporation End effector gripper arms having corner grippers which reorient reticle during transfer
WO2005007223A2 (en) * 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US7424318B2 (en) 2003-12-05 2008-09-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7467003B2 (en) * 2003-12-05 2008-12-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7366556B2 (en) 2003-12-05 2008-04-29 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7761130B2 (en) * 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7460898B2 (en) * 2003-12-05 2008-12-02 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
BRPI0413360A (pt) * 2003-08-04 2006-10-10 Alza Corp método e dispositivo para aumentar o fluxo de agentes transdérmicos
US7223248B2 (en) * 2003-08-13 2007-05-29 Lifescan, Inc. Packaged medical device with a deployable dermal tissue penetration member
US8233959B2 (en) 2003-08-22 2012-07-31 Dexcom, Inc. Systems and methods for processing analyte sensor data
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
CN1842355A (zh) * 2003-08-26 2006-10-04 阿尔扎公司 用于皮内细胞植入的装置和方法
US7099968B2 (en) * 2003-09-02 2006-08-29 Intel Corporation System and method for generating bus requests in advance based on speculation states
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
WO2005037095A1 (en) 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
BRPI0415466A (pt) * 2003-10-24 2006-12-19 Alza Corp método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos
US8016811B2 (en) * 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
CN1897899A (zh) * 2003-10-24 2007-01-17 阿尔扎公司 促进透皮药物传递的装置和方法
US7455654B2 (en) * 2003-10-28 2008-11-25 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
AU2004287414B2 (en) 2003-10-31 2010-11-25 Alza Corporation Self-actuating applicator for microprojection array
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
USD902408S1 (en) 2003-11-05 2020-11-17 Abbott Diabetes Care Inc. Analyte sensor control unit
US20060036209A1 (en) * 2003-11-13 2006-02-16 Janardhanan Subramony System and method for transdermal delivery
DE10353629A1 (de) * 2003-11-17 2005-06-16 Lts Lohmann Therapie-Systeme Ag Vorrichtung zur transdermalen Verabreichung von Wirkstoffen
US20090054842A1 (en) * 2003-11-18 2009-02-26 Nanopass Technologies Ltd. Enhanced penetration system and method for sliding microneedles
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
WO2005051455A2 (en) * 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
EP1713533A4 (de) * 2003-11-21 2008-01-23 Univ California Verfahren und/oder vorrichtung zur punktierung einer fläche zur extraktion, in-situ-analyse und/oder substanzzufuhr unter verwendung von mikronadeln
MXPA06006041A (es) * 2003-11-28 2007-01-31 Acrux Dds Pty Ltd Metodo y sistema para administracion transdermica rapida.
US8532730B2 (en) 2006-10-04 2013-09-10 Dexcom, Inc. Analyte sensor
EP2239567B1 (de) 2003-12-05 2015-09-02 DexCom, Inc. Kalibrierverfahren für einen kontinuierlichen Analytsensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (de) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Verfahren und vorrichtung zur verbesserung der fluidströmung und der probennahme
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US20080312555A1 (en) * 2004-02-06 2008-12-18 Dirk Boecker Devices and methods for glucose measurement using rechargeable battery energy sources
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
WO2009048462A1 (en) 2007-10-09 2009-04-16 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
EP1737357B1 (de) * 2004-03-24 2019-12-11 Corium, Inc. Vorrichtung zur transdermalen abgabe
CA2560784A1 (en) 2004-03-26 2005-10-06 Unomedical A/S Infusion set
JP2007537783A (ja) * 2004-04-13 2007-12-27 アルザ コーポレイション 複数のワクチンを経皮送達するための装置及び方法
WO2006104498A2 (en) * 2004-04-20 2006-10-05 University Of Rochester Hydrogel-supported porous semiconductor devices
AU2005244734A1 (en) * 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
MXPA06013490A (es) * 2004-05-19 2007-06-12 Johnson & Johnson Metodo y formulacion para el suministro transdermico de agentes inmunologicamente activos.
EP1751546A2 (de) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Bedruckbares wassergel für biosensoren
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US7315758B2 (en) 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
EP1810185A4 (de) 2004-06-04 2010-01-06 Therasense Inc Diabetes-versorgungs-host-client-architektur und datenverwaltungssystem
US20050273075A1 (en) * 2004-06-08 2005-12-08 Peter Krulevitch Method for delivering drugs to the adventitia using device having microprojections
US20050273049A1 (en) * 2004-06-08 2005-12-08 Peter Krulevitch Drug delivery device using microprojections
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US20060270922A1 (en) 2004-07-13 2006-11-30 Brauker James H Analyte sensor
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US7640048B2 (en) 2004-07-13 2009-12-29 Dexcom, Inc. Analyte sensor
US20060016700A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US7713574B2 (en) 2004-07-13 2010-05-11 Dexcom, Inc. Transcutaneous analyte sensor
US7537590B2 (en) * 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060030788A1 (en) * 2004-08-04 2006-02-09 Daniel Wong Apparatus and method for extracting bodily fluid utilizing a flat lancet
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
US20060058602A1 (en) * 2004-08-17 2006-03-16 Kwiatkowski Krzysztof C Interstitial fluid analyzer
WO2006022784A1 (en) * 2004-08-23 2006-03-02 U.S. Smokeless Tobacco Company Nicotiana compositions
AU2005282401A1 (en) * 2004-09-08 2006-03-16 Alza Corporation Microprojection array with improved skin adhesion and compliance
US20080085289A1 (en) 2004-09-22 2008-04-10 Cindy Castado Immunogenic Composition
TW200626177A (en) * 2004-09-28 2006-08-01 Alza Corp Method and formulation for stabilizing alum-adsorbed vaccines
ITPD20040252A1 (it) * 2004-10-14 2005-01-14 Bidoia Sas Di Gianfranco Bidoi Irrigatore chirurgico
JP4416625B2 (ja) * 2004-10-29 2010-02-17 シスメックス株式会社 組織切断器具、組織切断補助器具および収納容器
US8267889B2 (en) * 2004-11-18 2012-09-18 3M Innovative Properties Company Low-profile microneedle array applicator
EP1838383B1 (de) * 2004-11-18 2011-04-06 3M Innovative Properties Company Mikronadelanordungsapplikator und halter
JP5015787B2 (ja) 2004-11-18 2012-08-29 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイの接触コーティング法
CN101102809B (zh) * 2004-11-18 2010-05-26 3M创新有限公司 涂敷微针阵列的遮蔽方法
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
CN100367906C (zh) * 2004-12-08 2008-02-13 圣美迪诺医疗科技(湖州)有限公司 皮下植入式生物传感器
WO2006061027A2 (en) * 2004-12-10 2006-06-15 Unomedical A/S Cannula inserter
WO2006077742A1 (ja) * 2004-12-28 2006-07-27 Nabtesco Corporation 皮膚用針製造装置および皮膚用針製造方法
US20090105569A1 (en) 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US10226207B2 (en) 2004-12-29 2019-03-12 Abbott Diabetes Care Inc. Sensor inserter having introducer
US7731657B2 (en) * 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US20090082693A1 (en) * 2004-12-29 2009-03-26 Therasense, Inc. Method and apparatus for providing temperature sensor module in a data communication system
US7883464B2 (en) 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US9398882B2 (en) 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US9259175B2 (en) 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US9743862B2 (en) 2011-03-31 2017-08-29 Abbott Diabetes Care Inc. Systems and methods for transcutaneously implanting medical devices
US8571624B2 (en) 2004-12-29 2013-10-29 Abbott Diabetes Care Inc. Method and apparatus for mounting a data transmission device in a communication system
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US9572534B2 (en) 2010-06-29 2017-02-21 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US7697967B2 (en) 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US9636450B2 (en) 2007-02-19 2017-05-02 Udo Hoss Pump system modular components for delivering medication and analyte sensing at seperate insertion sites
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
EP1846095A4 (de) * 2005-01-20 2014-03-05 Epley Medical Llc Minimal invasives intratympanisches wirkstoffabgabesystem mit verzögerter freisetzung
TW200640519A (en) * 2005-02-16 2006-12-01 Alza Corp Microprojection arrays with improved biocompatibility
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
MX2007011338A (es) * 2005-03-21 2007-11-09 Unomedical As Una almohadilla de montaje, un dispositivo adhesivo que comprende dicha almohadilla de montaje y metodos para aplicar tales dispositivos a un paciente.
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
CA2602259A1 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US20100179508A1 (en) * 2005-06-28 2010-07-15 Unomedical A/S Packing for an infusion set and method of applying an infusion set
US20070004989A1 (en) * 2005-06-29 2007-01-04 Parvinder Dhillon Device for transdermal sampling
US20070025869A1 (en) * 2005-07-15 2007-02-01 Gordon John H Fluid Delivery Device
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
US8386030B2 (en) * 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
US20080314395A1 (en) 2005-08-31 2008-12-25 Theuniversity Of Virginia Patent Foundation Accuracy of Continuous Glucose Sensors
ES2478623T3 (es) * 2005-09-06 2014-07-22 Theraject, Inc. Perforador de solución sólido que contiene partículas de medicamentos y/o partículas adsorbentes de medicamentos
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
WO2007033015A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Coatable transdermal delivery microprojection assembly
PL1762259T3 (pl) 2005-09-12 2011-03-31 Unomedical As Urządzenie wprowadzające, przeznaczone do zestawu infuzyjnego, z pierwszą i drugą jednostką sprężynową
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
CN101415368A (zh) * 2005-09-26 2009-04-22 皇家飞利浦电子股份有限公司 经由皮肤进行物质采样和/或物质输送
CA2624059C (en) 2005-09-30 2019-04-02 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US9521968B2 (en) 2005-09-30 2016-12-20 Abbott Diabetes Care Inc. Analyte sensor retention mechanism and methods of use
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US20070083185A1 (en) * 2005-09-30 2007-04-12 Darrick Carter Iontophoretic device and method of delivery of active agents to biological interface
WO2007041526A2 (en) * 2005-09-30 2007-04-12 Transcutaneous Technologies Inc. Iontophoresis apparatus and method to deliver antibiotics to biological interfaces
US20070078376A1 (en) * 2005-09-30 2007-04-05 Smith Gregory A Functionalized microneedles transdermal drug delivery systems, devices, and methods
US8880138B2 (en) 2005-09-30 2014-11-04 Abbott Diabetes Care Inc. Device for channeling fluid and methods of use
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US7842008B2 (en) 2005-11-21 2010-11-30 Becton, Dickinson And Company Intradermal delivery device
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
EP1962942A1 (de) * 2005-12-21 2008-09-03 3M Innovative Properties Company Mikronadelvorrichtungen
US20070142781A1 (en) * 2005-12-21 2007-06-21 Sayre Chauncey B Microinjector chip
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
CA2633772C (en) 2005-12-22 2015-09-15 Ralph Leon Biemans Pneumococcal polysaccharide conjugate vaccine
US9278173B2 (en) 2005-12-23 2016-03-08 Unomedical A/S Device for administration
JP2009522288A (ja) 2005-12-28 2009-06-11 アルザ コーポレイション 安定な治療剤形
US11298058B2 (en) 2005-12-28 2022-04-12 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
WO2007120363A2 (en) 2005-12-28 2007-10-25 Abbott Diabetes Care, Inc. Medical device insertion
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US7736310B2 (en) 2006-01-30 2010-06-15 Abbott Diabetes Care Inc. On-body medical device securement
US8419708B2 (en) 2006-02-10 2013-04-16 Hisamitsu Pharmaceuticals Co., Inc. Transdermal drug administration apparatus having microneedles
KR20080104342A (ko) 2006-02-28 2008-12-02 우노메디컬 에이/에스 바늘 보호구를 구비하는 주입부와 주입부용 인서터
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US7826879B2 (en) 2006-02-28 2010-11-02 Abbott Diabetes Care Inc. Analyte sensors and methods of use
WO2007106597A2 (en) * 2006-03-15 2007-09-20 Alza Corporation Method for the transdermal delivery of parathyroid hormone agents for treating osteopenia
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
KR101541383B1 (ko) 2006-03-30 2015-08-03 글락소스미스클라인 바이오로지칼즈 에스.에이. 면역원성 조성물
US7630748B2 (en) 2006-10-25 2009-12-08 Abbott Diabetes Care Inc. Method and system for providing analyte monitoring
US8219173B2 (en) 2008-09-30 2012-07-10 Abbott Diabetes Care Inc. Optimizing analyte sensor calibration
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US8224415B2 (en) 2009-01-29 2012-07-17 Abbott Diabetes Care Inc. Method and device for providing offset model based calibration for analyte sensor
US7618369B2 (en) 2006-10-02 2009-11-17 Abbott Diabetes Care Inc. Method and system for dynamically updating calibration parameters for an analyte sensor
US7801582B2 (en) 2006-03-31 2010-09-21 Abbott Diabetes Care Inc. Analyte monitoring and management system and methods therefor
US8374668B1 (en) 2007-10-23 2013-02-12 Abbott Diabetes Care Inc. Analyte sensor with lag compensation
US9392969B2 (en) 2008-08-31 2016-07-19 Abbott Diabetes Care Inc. Closed loop control and signal attenuation detection
US8346335B2 (en) 2008-03-28 2013-01-01 Abbott Diabetes Care Inc. Analyte sensor calibration management
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US8473022B2 (en) 2008-01-31 2013-06-25 Abbott Diabetes Care Inc. Analyte sensor with time lag compensation
US7653425B2 (en) 2006-08-09 2010-01-26 Abbott Diabetes Care Inc. Method and system for providing calibration of an analyte sensor in an analyte monitoring system
US9675290B2 (en) 2012-10-30 2017-06-13 Abbott Diabetes Care Inc. Sensitivity calibration of in vivo sensors used to measure analyte concentration
US8140312B2 (en) 2007-05-14 2012-03-20 Abbott Diabetes Care Inc. Method and system for determining analyte levels
WO2007116959A1 (ja) 2006-04-07 2007-10-18 Hisamitsu Pharmaceutical Co., Inc. マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
CA2650193A1 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with sculptured microprojections for high drug loading
US20070299388A1 (en) * 2006-04-25 2007-12-27 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
WO2007127811A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with grouped microprojections for high drug loading
WO2007143225A2 (en) 2006-06-07 2007-12-13 Abbott Diabetes Care, Inc. Analyte monitoring system and method
MX2008015245A (es) 2006-06-07 2008-12-15 Unomedical As Insertador.
WO2007140785A1 (en) 2006-06-09 2007-12-13 Unomedical A/S Mounting pad
WO2008008845A2 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
MX2009001119A (es) 2006-08-02 2009-06-02 Unomedical As Canula y dispositivo de administracion.
JP2010502267A (ja) * 2006-08-28 2010-01-28 エージェンシー・フォー・サイエンス・テクノロジー・アンド・リサーチ マイクロニードルおよびマイクロニードルの製造方法
WO2008027218A2 (en) * 2006-08-29 2008-03-06 Alza Corporation Drug electrotransport with hydration measurement of hydratable reservoir
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US8192474B2 (en) 2006-09-26 2012-06-05 Zeltiq Aesthetics, Inc. Tissue treatment methods
US9132031B2 (en) 2006-09-26 2015-09-15 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US7831287B2 (en) * 2006-10-04 2010-11-09 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP2086582B1 (de) 2006-10-12 2012-11-14 GlaxoSmithKline Biologicals s.a. Impfstoff mit einem öl-in-wasser-emulsionshilfsstoff
CA2664619C (en) 2006-10-12 2012-12-11 Glaxosmithkline Biologicals S.A. Immunogenic compositions comprising an oil-in-water emulsion adjuvant containing a reduced amount of squalene, tocol and an emulsifying agent
BRPI0718119A2 (pt) 2006-10-26 2014-07-08 Abbott Diabetes Care Inc Métodos, sistemas e programas de computador para a detecção em tempo real do declínio de sensibilidade em sensores de analito
EP1917990A1 (de) 2006-10-31 2008-05-07 Unomedical A/S Infusionsset
WO2008067409A2 (en) * 2006-11-28 2008-06-05 Polyplus Battery Company Protected lithium electrodes for electro-transport drug delivery
US7785301B2 (en) * 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
US20080147186A1 (en) * 2006-12-14 2008-06-19 Joshi Ashok V Electrochemical Implant For Delivering Beneficial Agents
EP2121111B1 (de) * 2007-01-22 2018-03-14 Corium International, Inc. Applikator für mikronadelanordnung
ES2622555T3 (es) * 2007-01-22 2017-07-06 Nitto Denko Corporation Sistema de administración transdérmica de permeante
US20080199894A1 (en) 2007-02-15 2008-08-21 Abbott Diabetes Care, Inc. Device and method for automatic data acquisition and/or detection
US8121857B2 (en) 2007-02-15 2012-02-21 Abbott Diabetes Care Inc. Device and method for automatic data acquisition and/or detection
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
CA2683930A1 (en) 2007-04-14 2008-10-23 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
US9204827B2 (en) 2007-04-14 2015-12-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
WO2008130895A2 (en) 2007-04-14 2008-10-30 Abbott Diabetes Care, Inc. Method and apparatus for providing dynamic multi-stage signal amplification in a medical device
US9615780B2 (en) 2007-04-14 2017-04-11 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
US10111608B2 (en) 2007-04-14 2018-10-30 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
CA2683962C (en) 2007-04-14 2017-06-06 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in medical communication system
EP2146689B1 (de) 2007-04-16 2020-08-12 Corium, Inc. Einen wirkstoff enthaltende lösungsmittel-gegossene mikronadelanordnungen
US8911749B2 (en) * 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US8439861B2 (en) 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
WO2008137747A1 (en) 2007-05-02 2008-11-13 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8239166B2 (en) 2007-05-14 2012-08-07 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US7996158B2 (en) 2007-05-14 2011-08-09 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8103471B2 (en) 2007-05-14 2012-01-24 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8260558B2 (en) 2007-05-14 2012-09-04 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US9125548B2 (en) 2007-05-14 2015-09-08 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US10002233B2 (en) 2007-05-14 2018-06-19 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8600681B2 (en) 2007-05-14 2013-12-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8560038B2 (en) 2007-05-14 2013-10-15 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US8444560B2 (en) 2007-05-14 2013-05-21 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US20080287839A1 (en) 2007-05-18 2008-11-20 Juniper Medical, Inc. Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator
WO2008150917A1 (en) * 2007-05-31 2008-12-11 Abbott Diabetes Care, Inc. Insertion devices and methods
US20080306434A1 (en) 2007-06-08 2008-12-11 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
DK2155311T3 (da) 2007-06-20 2013-02-04 Unomedical As Fremgangsmåde og apparat til fremstilling af et kateter
EP2171031B1 (de) 2007-06-21 2018-12-05 Abbott Diabetes Care Inc. Health management devices and methods
AU2008265542B2 (en) 2007-06-21 2014-07-24 Abbott Diabetes Care Inc. Health monitor
PL2167121T3 (pl) 2007-06-26 2016-01-29 Glaxosmithkline Biologicals Sa Szczepionka zawierająca koniugaty polisacharydu otoczkowego streptococcus pneumoniae
WO2009006349A2 (en) * 2007-06-29 2009-01-08 Polyplus Battery Company Electrotransport devices, methods and drug electrode assemblies
US8160900B2 (en) 2007-06-29 2012-04-17 Abbott Diabetes Care Inc. Analyte monitoring and management device and method to analyze the frequency of user interaction with the device
WO2009004026A1 (en) 2007-07-03 2009-01-08 Unomedical A/S Inserter having bistable equilibrium states
ES2360842T3 (es) 2007-07-10 2011-06-09 Unomedical A/S Dispositivo de inserción con dos muelles.
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
CN101801439A (zh) 2007-07-18 2010-08-11 优诺医疗有限公司 具有枢转运动的插入装置
US8834366B2 (en) 2007-07-31 2014-09-16 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor calibration
US7768386B2 (en) * 2007-07-31 2010-08-03 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
KR101522747B1 (ko) * 2007-08-06 2015-05-26 알레간 인코포레이티드 데스모프레신 약물 전달을 위한 방법 및 장치
WO2009021048A2 (en) 2007-08-06 2009-02-12 Transderm, Inc. Microneedle arrays formed from polymer films
JP5474791B2 (ja) 2007-08-21 2014-04-16 ゼルティック エステティックス インコーポレイテッド 脂肪組織の冷却のような皮下脂質リッチ細胞の冷却の監視
US20090069740A1 (en) * 2007-09-07 2009-03-12 Polyplus Battery Company Protected donor electrodes for electro-transport drug delivery
ES2612061T3 (es) * 2007-09-28 2017-05-11 The Queen's University Of Belfast Dispositivo y método de suministro
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US8216138B1 (en) 2007-10-23 2012-07-10 Abbott Diabetes Care Inc. Correlation of alternative site blood and interstitial fluid glucose concentrations to venous glucose concentration
US8377031B2 (en) 2007-10-23 2013-02-19 Abbott Diabetes Care Inc. Closed loop control system with safety parameters and methods
US8409093B2 (en) 2007-10-23 2013-04-02 Abbott Diabetes Care Inc. Assessing measures of glycemic variability
US20090164239A1 (en) 2007-12-19 2009-06-25 Abbott Diabetes Care, Inc. Dynamic Display Of Glucose Information
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
US7766846B2 (en) 2008-01-28 2010-08-03 Roche Diagnostics Operations, Inc. Rapid blood expression and sampling
US8883015B2 (en) 2008-02-07 2014-11-11 The University Of Queensland Patch production
PL2252349T3 (pl) 2008-02-13 2012-01-31 Unomedical As Uszczelnienie między częścią kaniulową a drogą przepływu płynu
US8157747B2 (en) * 2008-02-15 2012-04-17 Lary Research & Development, Llc Single-use indicator for a surgical instrument and a surgical instrument incorporating same
US9566384B2 (en) 2008-02-20 2017-02-14 Unomedical A/S Insertion device with horizontally moving part
WO2009146072A1 (en) 2008-04-01 2009-12-03 The General Hospital Corporation Method and apparatus for tissue expansion
US20090259176A1 (en) * 2008-04-09 2009-10-15 Los Gatos Research, Inc. Transdermal patch system
ES2546087T3 (es) 2008-04-10 2015-09-18 Abbott Diabetes Care Inc. Procedimiento y sistema para esterilizar un detector de analitos
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
PT2271360E (pt) 2008-04-16 2015-12-07 Glaxosmithkline Biolog Sa Vacina
HUE039013T4 (hu) * 2008-05-21 2019-08-28 Ferring Bv Orodiszperzibilis dezmopresszin az alvás noktúria által meg nem zavart kezdeti szakaszának megnövelésére
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
CA2728400C (en) * 2008-05-21 2014-03-25 Theraject, Inc. Method of manufacturing solid solution peforator patches and uses thereof
WO2009140735A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents.
EP2293719B1 (de) 2008-05-30 2015-09-09 Intuity Medical, Inc. Schnittstelle zwischen einer Vorrichtung zur entnahme von Körperflüssigkeitsproben und der Entnahmestelle
US8924159B2 (en) 2008-05-30 2014-12-30 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
US7826382B2 (en) 2008-05-30 2010-11-02 Abbott Diabetes Care Inc. Close proximity communication device and methods
US8591410B2 (en) 2008-05-30 2013-11-26 Abbott Diabetes Care Inc. Method and apparatus for providing glycemic control
JP2011522616A (ja) * 2008-06-04 2011-08-04 セブンス センス バイオシステムズ，インコーポレーテッド シングルステップ診断のための組成物および方法
WO2009148626A1 (en) 2008-06-06 2009-12-10 Intuity Medical, Inc. Medical diagnostic devices and methods
WO2009148624A1 (en) 2008-06-06 2009-12-10 Intuity Medical, Inc. Detection meter and mode of operation
WO2009158032A1 (en) * 2008-06-25 2009-12-30 Fe2, Inc. Patches and methods for the transdermal delivery of a therapeutically effective amount of iron
US8876755B2 (en) 2008-07-14 2014-11-04 Abbott Diabetes Care Inc. Closed loop control system interface and methods
US8202531B2 (en) * 2008-07-23 2012-06-19 Warsaw Orthopedic, Inc. Drug depots having one or more anchoring members
EP2149957B1 (de) * 2008-07-30 2017-06-14 Harman Becker Automotive Systems GmbH Stromverteilung nach Priorität
US20100057040A1 (en) 2008-08-31 2010-03-04 Abbott Diabetes Care, Inc. Robust Closed Loop Control And Methods
US9943644B2 (en) 2008-08-31 2018-04-17 Abbott Diabetes Care Inc. Closed loop control with reference measurement and methods thereof
US8734422B2 (en) 2008-08-31 2014-05-27 Abbott Diabetes Care Inc. Closed loop control with improved alarm functions
US8622988B2 (en) 2008-08-31 2014-01-07 Abbott Diabetes Care Inc. Variable rate closed loop control and methods
US10383985B2 (en) * 2008-09-09 2019-08-20 Oxyband Technologies, Inc. Methods and apparatus for charging and evacuating a diffusion dressing
US20100092526A1 (en) 2008-09-26 2010-04-15 Nanobio Corporation Nanoemulsion therapeutic compositions and methods of using the same
US8986208B2 (en) 2008-09-30 2015-03-24 Abbott Diabetes Care Inc. Analyte sensor sensitivity attenuation mitigation
US9326707B2 (en) 2008-11-10 2016-05-03 Abbott Diabetes Care Inc. Alarm characterization for analyte monitoring devices and systems
US9974844B2 (en) 2008-11-17 2018-05-22 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
MX2011005735A (es) 2008-12-22 2011-06-21 Unomedical As Dispositivo medico que comprende una almohadilla de adhesivo.
EA201100891A1 (ru) * 2008-12-30 2012-05-30 Нюпэф Инк. Электронный контроль системы доставки лекарственного средства
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
US10136816B2 (en) 2009-08-31 2018-11-27 Abbott Diabetes Care Inc. Medical devices and methods
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
CN102405015B (zh) 2009-03-02 2017-01-18 第七感生物系统有限公司 用于分析可提取介质的装置和方法
US20110172508A1 (en) * 2010-01-13 2011-07-14 Seventh Sense Biosystems, Inc. Sampling device interfaces
US8781576B2 (en) * 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
WO2010107707A2 (en) 2009-03-17 2010-09-23 Savage Walter T External defibrillator
US8617487B2 (en) 2009-03-25 2013-12-31 Venture Lending & Leasing Vi, Inc. Saliva sample collection systems
CN101829396B (zh) * 2009-03-27 2013-01-30 清华大学 微针阵列芯片及利用其的经皮给药贴剂及其制备方法
WO2010121084A1 (en) 2009-04-15 2010-10-21 Abbott Diabetes Care Inc. Analyte monitoring system having an alert
EP2419015A4 (de) 2009-04-16 2014-08-20 Abbott Diabetes Care Inc Kalibrierung eines analytsensors
EP2429627B1 (de) * 2009-04-24 2017-06-14 Corium International, Inc. Verfahren zur herstellung von mikroprojektionsarrays
US8821945B2 (en) * 2009-04-25 2014-09-02 Fe3 Medical, Inc. Method for transdermal iontophoretic delivery of chelated agents
WO2010127050A1 (en) 2009-04-28 2010-11-04 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
EP2425209A4 (de) 2009-04-29 2013-01-09 Abbott Diabetes Care Inc Verfahren und system für die echtzeit-kalibrierung eines analytsensors mit rückwirkender füllung
GB2469839B (en) * 2009-04-29 2014-09-10 Cook Medical Technologies Llc Medical instrument
US8368556B2 (en) 2009-04-29 2013-02-05 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
BRPI1014623B1 (pt) 2009-04-30 2020-01-07 Zeltiq Aesthetics, Inc. Sistema para tratamento de celulas subcutâneas ricas em lipídeos em uma área alvo
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
WO2010144670A1 (en) * 2009-06-10 2010-12-16 Medtronic, Inc. Device and method for monitoring of absolute oxygen saturation and tissue hemoglobin concentration
EP2442827B1 (de) 2009-06-16 2016-01-06 The Regents of the University of Michigan Nanoemulsionsimpfstoffe
US8613892B2 (en) 2009-06-30 2013-12-24 Abbott Diabetes Care Inc. Analyte meter with a moveable head and methods of using the same
EP4289355A3 (de) 2009-07-23 2024-02-28 Abbott Diabetes Care Inc. System zur kontinuierlichen analytmessung
EP2459252B1 (de) 2009-07-30 2013-08-21 Unomedical A/S Inserter mit horizontalem beweglichem teil
WO2011014851A1 (en) 2009-07-31 2011-02-03 Abbott Diabetes Care Inc. Method and apparatus for providing analyte monitoring system calibration accuracy
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
JP2013500805A (ja) 2009-08-07 2013-01-10 ウノメディカル・アー／エス センサおよび１つまたは複数のカニューレを有する投与装置
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
WO2011026148A1 (en) 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Analyte monitoring system and methods for managing power and noise
WO2011026147A1 (en) 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Analyte signal processing device and methods
EP4147999A1 (de) 2009-08-31 2023-03-15 Abbott Diabetes Care, Inc. Anzeigen für eine medizinische vorrichtung
US20130018279A1 (en) * 2009-09-01 2013-01-17 Pathway Genomics "blood sample collection apparatus and kits"
US9320461B2 (en) 2009-09-29 2016-04-26 Abbott Diabetes Care Inc. Method and apparatus for providing notification function in analyte monitoring systems
WO2011041531A1 (en) 2009-09-30 2011-04-07 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
WO2011053881A1 (en) 2009-10-30 2011-05-05 Abbott Diabetes Care Inc. Method and apparatus for detecting false hypoglycemic conditions
WO2011053787A2 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for application to skin and control of actuation, delivery and/or perception thereof
WO2011053796A2 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin
WO2011065972A2 (en) * 2009-11-24 2011-06-03 Seventh Sense Biosystems, Inc. Patient-enacted sampling technique
WO2011065981A1 (en) 2009-11-30 2011-06-03 Intuity Medical, Inc. Calibration material delivery devices and methods
CN102811754B (zh) * 2010-01-13 2017-05-17 第七感生物系统有限公司 流体的快速输送和/或抽出
AU2011207506A1 (en) 2010-01-25 2012-08-09 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associated devices, systems and methods
USD924406S1 (en) 2010-02-01 2021-07-06 Abbott Diabetes Care Inc. Analyte sensor inserter
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
WO2011112753A1 (en) 2010-03-10 2011-09-15 Abbott Diabetes Care Inc. Systems, devices and methods for managing glucose levels
EP3622883B1 (de) 2010-03-24 2021-06-30 Abbott Diabetes Care, Inc. Medizinische vorrichtungseinführer und verfahren zum einführen und verwenden von medizinischen vorrichtungen
MX2012011085A (es) 2010-03-30 2012-10-10 Unomedical As Dispositivo medico.
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP2563460B1 (de) 2010-04-28 2017-07-19 Inovio Pharmaceuticals, Inc. Mundschleimhaut-elektroporationsvorrichtung und verwendung davon
EP2566501B1 (de) 2010-05-04 2019-03-13 Corium International, Inc. Verfahren und vorrichtung zur transdermalen verabreichung von parathormon mithilfe eines mikroprojektions-arrays
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
US8635046B2 (en) 2010-06-23 2014-01-21 Abbott Diabetes Care Inc. Method and system for evaluating analyte sensor response characteristics
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
US10092229B2 (en) 2010-06-29 2018-10-09 Abbott Diabetes Care Inc. Calibration of analyte measurement system
US11064921B2 (en) 2010-06-29 2021-07-20 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
WO2012009613A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure environment for fluid transfer devices
US8676338B2 (en) 2010-07-20 2014-03-18 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
EP2603256B1 (de) * 2010-08-13 2015-07-22 Seventh Sense Biosystems, Inc. Verfahren und vorrichtungen für die medizin und/oder verbraucher
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
EP2433663A1 (de) 2010-09-27 2012-03-28 Unomedical A/S Einführsystem
EP2436412A1 (de) 2010-10-04 2012-04-04 Unomedical A/S Sprinklerkanüle
WO2012048168A2 (en) 2010-10-07 2012-04-12 Abbott Diabetes Care Inc. Analyte monitoring devices and methods
US10024510B2 (en) * 2010-10-26 2018-07-17 Steven G. Hammond Flexible light emitting diode lighting process and assembly
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
WO2012103242A1 (en) 2011-01-25 2012-08-02 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
US10136845B2 (en) 2011-02-28 2018-11-27 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
CA3115682A1 (en) 2011-02-28 2012-11-15 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
ES2847578T3 (es) 2011-04-15 2021-08-03 Dexcom Inc Calibración avanzada de sensor de analito y detección de errores
WO2012149143A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Delivering and/or receiving fluids
AU2012249683A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Devices and methods for collection and/or manipulation of blood spots or other bodily fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
WO2012149155A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
CA2834834A1 (en) 2011-05-17 2012-11-22 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
EP3750480B1 (de) 2011-08-03 2022-02-02 Intuity Medical, Inc. Vorrichtung zur entnahme von körperflüssigkeiten
CN103957962B (zh) 2011-10-05 2017-07-07 犹诺医药有限公司 用于同时插入多个经皮部分的插入物
EP2765927B1 (de) 2011-10-12 2021-02-24 Vaxxas Pty Limited Abgabegerät
US10010707B2 (en) 2011-10-12 2018-07-03 3M Innovative Properties Company Integrated microneedle array delivery system
US8585721B2 (en) * 2011-10-12 2013-11-19 Covidien Lp Mesh fixation system
EP2583715A1 (de) 2011-10-19 2013-04-24 Unomedical A/S Infusionsschlauchsystem und Herstellungsverfahren
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
WO2013066873A1 (en) 2011-10-31 2013-05-10 Abbott Diabetes Care Inc. Electronic devices having integrated reset systems and methods thereof
US9622691B2 (en) 2011-10-31 2017-04-18 Abbott Diabetes Care Inc. Model based variable risk false glucose threshold alarm prevention mechanism
AU2012335830B2 (en) 2011-11-07 2017-05-04 Abbott Diabetes Care Inc. Analyte monitoring device and methods
US8710993B2 (en) 2011-11-23 2014-04-29 Abbott Diabetes Care Inc. Mitigating single point failure of devices in an analyte monitoring system and methods thereof
US9317656B2 (en) 2011-11-23 2016-04-19 Abbott Diabetes Care Inc. Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof
WO2013078426A2 (en) 2011-11-25 2013-05-30 Abbott Diabetes Care Inc. Analyte monitoring system and methods of use
FI3300658T3 (fi) 2011-12-11 2024-03-01 Abbott Diabetes Care Inc Analyyttianturimenetelmiä
WO2013187392A1 (ja) * 2012-06-12 2013-12-19 久光製薬株式会社 マイクロニードル・シート
US10132793B2 (en) 2012-08-30 2018-11-20 Abbott Diabetes Care Inc. Dropout detection in continuous analyte monitoring data during data excursions
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
US9907492B2 (en) 2012-09-26 2018-03-06 Abbott Diabetes Care Inc. Method and apparatus for improving lag correction during in vivo measurement of analyte concentration with analyte concentration variability and range data
US20160128947A1 (en) * 2012-10-22 2016-05-12 Stc. Unm Bioadhesive films for local and/or systemic delivery
US9982034B2 (en) 2012-10-24 2018-05-29 Platelet Targeted Therapeutics, Llc Platelet targeted treatment
EP2934660B1 (de) 2012-12-21 2019-07-17 Corium, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe und verfahren zur herstellung davon
EP2958533B8 (de) 2013-02-20 2022-02-16 Cytrellis Biosystems, Inc. Verfahren und vorrichtungen zur hautstraffung
EP2968887B1 (de) 2013-03-12 2022-05-04 Corium, Inc. Mikroprojektionsapplikatoren
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
ES2761580T3 (es) 2013-03-15 2020-05-20 Corium Inc Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación
US10433773B1 (en) 2013-03-15 2019-10-08 Abbott Diabetes Care Inc. Noise rejection methods and apparatus for sparsely sampled analyte sensor data
JP2016514133A (ja) 2013-03-15 2016-05-19 コリウム インターナショナル， インコーポレイテッド ポリマーを含まない微細構造物を含むマイクロアレイ、製造方法および使用方法
US9474475B1 (en) 2013-03-15 2016-10-25 Abbott Diabetes Care Inc. Multi-rate analyte sensor data collection with sample rate configurable signal processing
ES2939317T3 (es) 2013-03-15 2023-04-20 Corium Pharma Solutions Inc Aplicadores de microproyección de impacto múltiple
MX2015012433A (es) 2013-03-15 2016-02-03 Corium Int Inc Matriz de microestructura para suministro de agentes activos.
BR112015022625B1 (pt) 2013-03-15 2023-01-31 Corium, Inc Aparelho de microestrutura para entrega de agente terapêutico
WO2014152034A1 (en) 2013-03-15 2014-09-25 Abbott Diabetes Care Inc. Sensor fault detection using analyte sensor data pattern comparison
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
WO2014205412A1 (en) 2013-06-21 2014-12-24 Intuity Medical, Inc. Analyte monitoring system with audible feedback
WO2015017561A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-profile microneedle patch applicator
WO2015021434A2 (en) 2013-08-09 2015-02-12 Cytrellis Biosystems, Inc. Methods and apparatuses for skin treatment using non-thermal tissue ablation
US9782585B2 (en) 2013-08-27 2017-10-10 Halo Neuro, Inc. Method and system for providing electrical stimulation to a user
US9486618B2 (en) 2013-08-27 2016-11-08 Halo Neuro, Inc. Electrode system for electrical stimulation
CN105492067B (zh) 2013-08-27 2017-07-25 哈洛纽罗公司 用于电刺激的电极系统
US9630005B2 (en) 2013-08-27 2017-04-25 Halo Neuro, Inc. Method and system for providing electrical stimulation to a user
JP6272333B2 (ja) * 2013-09-06 2018-01-31 久光製薬株式会社 マイクロニードル・シート
DE102013219432A1 (de) * 2013-09-26 2015-03-26 Peter Röhr Blutentnahmevorrichtung und Verfahren zum Entnehmen von Blut
US10208102B2 (en) 2013-11-01 2019-02-19 University Of Oslo Albumin variants and uses thereof
EP3068426B1 (de) 2013-11-13 2020-02-12 University Of Oslo Aussenmembranvesikel und verwendungen davon
WO2015071763A2 (en) 2013-11-15 2015-05-21 Oslo Universitetssykehus Hf Ctl peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof
WO2015095675A1 (en) 2013-12-19 2015-06-25 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
RU2683203C2 (ru) 2013-12-31 2019-03-26 Эбботт Дайабитиз Кэр Инк. Снабженный автономным питанием датчик аналита и использующие его устройства
TWI548395B (zh) * 2014-01-28 2016-09-11 微凸科技股份有限公司 連續經皮微針監測系統
EP3099259A1 (de) 2014-01-31 2016-12-07 Zeltiq Aesthetics, Inc. Behandlungssysteme zur behandlung von drüsen durch kühlung
WO2015117089A1 (en) * 2014-02-01 2015-08-06 Axion Biosystems, Inc. Neural interfacing device
CN106061546A (zh) * 2014-02-10 2016-10-26 Lts勒曼治疗系统股份公司 微针系统及其制造方法
EP2905047A1 (de) * 2014-02-10 2015-08-12 LTS LOHMANN Therapie-Systeme AG Mikronadelsystem und Verfahren seiner Herstellung
EP3111987B1 (de) * 2014-02-27 2022-04-20 Hisamitsu Pharmaceutical Co., Inc. Mikronadelblech
US10675176B1 (en) 2014-03-19 2020-06-09 Zeltiq Aesthetics, Inc. Treatment systems, devices, and methods for cooling targeted tissue
USD777338S1 (en) 2014-03-20 2017-01-24 Zeltiq Aesthetics, Inc. Cryotherapy applicator for cooling tissue
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
US20170185748A1 (en) 2014-03-30 2017-06-29 Abbott Diabetes Care Inc. Method and Apparatus for Determining Meal Start and Peak Events in Analyte Monitoring Systems
US10952891B1 (en) 2014-05-13 2021-03-23 Zeltiq Aesthetics, Inc. Treatment systems with adjustable gap applicators and methods for cooling tissue
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
EP4218724A3 (de) 2014-08-29 2023-08-16 Corium Pharma Solutions, Inc. Mikrostrukturanordnung zur freisetzung von wirkstoffen
CN105455855B (zh) * 2014-09-04 2018-05-25 微凸科技股份有限公司 乳酸量测装置及运动训练调整的方法
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016039333A1 (ja) * 2014-09-08 2016-03-17 株式会社かいわ 穿刺器具
JP5967595B2 (ja) * 2014-09-08 2016-08-10 株式会社かいわ 穿刺器具
EP3204039B1 (de) 2014-10-10 2022-06-08 The Regents Of The University Of Michigan Nanoemulsionszusammensetzungen zur prävention, unterdrückung oder eliminierung von allergischen und entzündlichen erkrankungen
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
AR102548A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y uso
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
US11324534B2 (en) 2014-11-14 2022-05-10 Cytrellis Biosystems, Inc. Devices and methods for ablation of the skin
WO2016088886A1 (ja) 2014-12-05 2016-06-09 久光製薬株式会社 マイクロニードルデバイスシステム
CA3204959A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
EP4226937A3 (de) 2015-03-05 2023-09-27 Northwestern University Nichtneuroinvasive viren und verwendungen davon
EP3294134B1 (de) 2015-05-14 2020-07-08 Abbott Diabetes Care Inc. Einführsystem für kompakte medizinische vorrichtung sowie zugehöriges verfahren
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
CA2991716A1 (en) 2015-07-10 2017-01-19 Abbott Diabetes Care Inc. System, device and method of dynamic glucose profile response to physiological parameters
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
EP3364900B1 (de) 2015-10-19 2021-08-18 Zeltiq Aesthetics, Inc. Gefässbehandlungsverfahren zum kühlen von gefässstrukturen
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
US10315026B2 (en) 2015-10-26 2019-06-11 Halo Neuro, Inc. Electrode positioning system and method
WO2017120538A1 (en) 2016-01-07 2017-07-13 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
JP2019511255A (ja) 2016-01-11 2019-04-25 バーンダリ，インク． マイクロニードル組成物およびそれを使用する方法
US20180321212A1 (en) * 2016-01-27 2018-11-08 Undercover Colors, Inc. Methods and apparatus for detecting compounds in liquids
EP3413966A4 (de) 2016-02-08 2019-11-27 Halo Neuro, Inc. Verfahren und system zur verbesserung der bereitstellung von elektrischer stimulation
US10765552B2 (en) 2016-02-18 2020-09-08 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US9918932B2 (en) 2016-02-19 2018-03-20 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
JP2019513070A (ja) 2016-03-01 2019-05-23 キトテック メディカル， インコーポレイテッド 創傷閉鎖のための微細構造に基づくシステム、装置および方法
KR102561605B1 (ko) 2016-03-29 2023-08-01 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
US10555831B2 (en) 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
US10682297B2 (en) 2016-05-10 2020-06-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US11173207B2 (en) 2016-05-19 2021-11-16 The Regents Of The University Of Michigan Adjuvant compositions
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
US10485443B2 (en) 2016-06-20 2019-11-26 Halo Neuro, Inc. Electrical interface system
US20190184366A1 (en) * 2016-08-03 2019-06-20 Verndari, Inc. Microarrays and methods
US11464954B2 (en) 2016-09-21 2022-10-11 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
EP3570735A4 (de) 2017-01-23 2020-10-21 Abbott Diabetes Care Inc. Systeme, vorrichtungen und verfahren für analytsensoreinsatz
JP2020507422A (ja) 2017-02-17 2020-03-12 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 活性成分を含むマイクロニードルアレイ
US10525255B2 (en) 2017-03-08 2020-01-07 Halo Neuro, Inc. System for electrical stimulation
EP3595515A4 (de) 2017-03-14 2020-12-30 University of Connecticut Biologisch abbaubarer drucksensor
EP3600014A4 (de) 2017-03-21 2020-10-21 Abbott Diabetes Care Inc. Verfahren, vorrichtungen und system zur bereitstellung der diagnose und therapie von diabetischen zuständen
EP3381370B1 (de) * 2017-03-31 2019-11-20 RichHealth Technology Corporation Transdermales mikronadelfeldpflaster
CN115923337A (zh) 2017-03-31 2023-04-07 瓦克萨斯私人有限公司 用于涂覆表面的设备和方法
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology
AU2018285954A1 (en) 2017-06-13 2019-12-19 Vaxxas Pty Limited Quality control of substrate coatings
BR112019027387A8 (pt) 2017-06-23 2022-12-06 Univ Maryland Composições imunogênicas
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
IL272776B1 (en) 2017-08-23 2024-02-01 Zosano Pharma Corp A method for rapidly obtaining therapeutic concentrations of zolmitriptan for the treatment of migraines and cluster headaches
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
EP3678699A1 (de) 2017-09-07 2020-07-15 University Of Oslo Impfstoffmoleküle
US20220118076A1 (en) 2017-09-07 2022-04-21 University Of Oslo Vaccine molecules
US10524730B2 (en) * 2017-09-28 2020-01-07 Medtronic Minimed, Inc. Medical devices with microneedle arrays and methods for operating such medical devices
CN107874767B (zh) * 2017-10-12 2020-11-24 杭州博拓生物科技股份有限公司 一种检测样本中被分析物质的装置
CN111246797A (zh) 2017-10-24 2020-06-05 德克斯康公司 预连接分析物传感器
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
JP7295124B2 (ja) 2017-11-03 2023-06-20 タケダ ワクチン，インコーポレイテッド ジカワクチン及び免疫原性組成物、ならびにその使用方法
JP6920179B2 (ja) 2017-11-15 2021-08-18 新光電気工業株式会社 生体用電極部品及びその製造方法
US10507324B2 (en) 2017-11-17 2019-12-17 Halo Neuro, Inc. System and method for individualizing modulation
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
JP7305311B2 (ja) 2018-05-30 2023-07-10 ロレアル マイクロニードルシート
EP3810388A1 (de) 2018-06-25 2021-04-28 Corium, Inc. Hybridverfahren zur herstellung von mikrostrukturanordnungsformen, verfahren zur herstellung von mikrostrukturanordnungen und verwendungsverfahren
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
JP2020002084A (ja) 2018-06-29 2020-01-09 ロレアル マイクロニードルシートを使用する美容方法
JP7335061B2 (ja) 2018-06-29 2023-08-29 ロレアル マイクロニードルシートを使用する美容方法
JP2020018327A (ja) 2018-07-17 2020-02-06 ロレアル マイクロニードルシート
WO2020028472A1 (en) 2018-07-31 2020-02-06 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics
EP3860445B1 (de) * 2018-10-04 2023-07-19 Onio As Sensorsystem mit benachrichtigungsfunktion und verfahren zur kontinuierlichen und drahtlosen überwachung und analyse der temperatur in organismen
JP2020099513A (ja) 2018-12-21 2020-07-02 ロレアル マイクロニードルシートを使用するキット及び美容方法
US11826495B2 (en) 2019-03-01 2023-11-28 University Of Connecticut Biodegradable piezoelectric ultrasonic transducer system
USD1002852S1 (en) 2019-06-06 2023-10-24 Abbott Diabetes Care Inc. Analyte sensor device
CN114375181A (zh) * 2019-06-28 2022-04-19 帕斯帕特技术有限公司 用于控制向细丝装置递送能量的方法和系统
JP2021094146A (ja) 2019-12-16 2021-06-24 ロレアル マイクロニードルシートを使用する美容方法
US20210252256A1 (en) * 2020-02-19 2021-08-19 Ronald J. Berenson Microstructures to attach appliances to tissues
US11745001B2 (en) 2020-03-10 2023-09-05 University Of Connecticut Therapeutic bandage
WO2021256214A1 (en) 2020-06-17 2021-12-23 L'oreal Kit and cosmetic process using microneedle sheet
FR3113843B1 (fr) 2020-09-07 2024-03-15 Oreal Kit et traitement cosmetique utilisant une feuille de micro-aiguilles
USD999913S1 (en) 2020-12-21 2023-09-26 Abbott Diabetes Care Inc Analyte sensor inserter
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine
FR3135206A1 (fr) 2022-05-05 2023-11-10 L'oreal Processus cosmétique utilisant une feuille de micro-aiguilles
FR3139007A1 (fr) 2022-08-23 2024-03-01 L'oreal Composition convenant pour des traitements cosmétiques de substance kératineuse

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US946837A (en) 1908-11-05 1910-01-18 Cordelia L Common Fountain tonic-applicator.
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
FR1133709A (fr) 1955-10-17 1957-04-01 Dispositif destiné à l'application de nouveaux traitements médicaux
US2893392A (en) 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US2974787A (en) * 1960-05-10 1961-03-14 American Cyanamid Co Single use, prepackaged vaccinator
US3322121A (en) * 1965-11-26 1967-05-30 Oscar H Banker Skin-puncturing unit with a collapsible protective cover
CH522395A (fr) * 1968-07-26 1972-05-15 Micromedic Systems Inc Eprouvette destinée à la prise de sang percutanée et digitale
US3675766A (en) 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
JPS5029096U (de) * 1973-07-06 1975-04-02
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4014334A (en) 1976-02-02 1977-03-29 Alza Corporation Laminated osmotic system for dispensing beneficial agent
US4141359A (en) 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4127118B1 (en) * 1977-03-16 1995-12-19 Alvaro Latorre Method of effecting and enhancing an erection
GB2008200B (en) 1977-11-09 1982-10-20 Emerit Andre A C Source of vacuum and device for creating and maintaining anegative pressure in an enclosure
US4250878A (en) 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4383529A (en) 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4340048A (en) 1981-03-28 1982-07-20 Alza Corporation Self-driven hypodermic injector
US5370675A (en) * 1992-08-12 1994-12-06 Vidamed, Inc. Medical probe device and method
US4753651A (en) 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
USH356H (en) * 1985-02-27 1987-11-03 Medtronic, Inc. Epicardial lead having low threshold, low polarization myocardial electrode
SU1296174A1 (ru) * 1985-06-20 1987-03-15 Устиновский Государственный Медицинский Институт Устройство дл электрофореза лекарственных веществ
US4655766A (en) 1985-08-01 1987-04-07 Alza Corporation Fluid imbibing pump with self-regulating skin patch
US4756314A (en) 1985-10-28 1988-07-12 Alza Corporation Sweat collection patch
US4711247A (en) 1986-04-18 1987-12-08 Henry Fishman Allergy testing method and apparatus
US5080646A (en) 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
DE3735137A1 (de) * 1987-10-16 1989-05-03 Siemens Ag Anordnung zum abgeben von medikamenten bei einem implantierbaren medizinischen geraet
JP2907342B2 (ja) * 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア イオン滲透非侵襲的サンプリングまたは送出装置
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5438984A (en) 1988-09-08 1995-08-08 Sudor Partners Apparatus and method for the collection of analytes on a dermal patch
US5147296A (en) 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US4941517A (en) * 1988-10-20 1990-07-17 Galloway Trust Aseptic fluid transfer apparatus and methods
US5054499A (en) 1989-03-27 1991-10-08 Swierczek Remi D Disposable skin perforator and blood testing device
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
EP0429842B1 (de) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5036861A (en) 1990-01-11 1991-08-06 Sembrowich Walter L Method and apparatus for non-invasively monitoring plasma glucose levels
US5161532A (en) 1990-04-19 1992-11-10 Teknekron Sensor Development Corporation Integral interstitial fluid sensor
US5300100A (en) * 1990-08-22 1994-04-05 Advanced Warming Systems, Inc. Body warmer
US5158537A (en) * 1990-10-29 1992-10-27 Alza Corporation Iontophoretic delivery device and method of hydrating same
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
SE9101022D0 (sv) 1991-01-09 1991-04-08 Paal Svedman Medicinsk suganordning
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5122114A (en) * 1991-02-01 1992-06-16 Board Of Regents, University Of Texas System Method of using intramedullary catheter
US5231993A (en) 1991-11-20 1993-08-03 Habley Medical Technology Corporation Blood sampler and component tester with guide member
JP2572823Y2 (ja) 1992-02-13 1998-05-25 株式会社アドバンス 簡易採血器
US5484399A (en) * 1992-02-27 1996-01-16 Sloan-Kettering Institute For Cancer Research Process and device to reduce interstitial fluid pressure in tissue
US5309909A (en) 1992-05-22 1994-05-10 Physio-Control Corporation Combined skin preparation and monitoring electrode
JPH0670987A (ja) * 1992-08-28 1994-03-15 Katsuro Tachibana 薬物投与・体液採取ユニット及び装置
US5300110A (en) * 1992-10-15 1994-04-05 Angeion Corporation Dirk-based epicardial defibrillation electrode
JPH0824680B2 (ja) 1992-10-26 1996-03-13 日本電気株式会社 吸引浸出液採取装置
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
JP2630197B2 (ja) 1993-04-28 1997-07-16 株式会社ニッショー 血液吸出器具
US5582184A (en) * 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5885211A (en) 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
JPH084182A (ja) * 1994-06-17 1996-01-09 Nippon Steel Metal Prod Co Ltd フラットデッキプレート用のアンカー部材
DE69519023T2 (de) 1994-06-24 2001-06-13 Cygnus Therapeutic Systems Einrichtung zur iontophoretischen probennahme
CA2205444A1 (en) * 1994-12-09 1996-06-13 Novartis Ag Transdermal system
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
US5571162A (en) * 1995-06-07 1996-11-05 Intermedics, Inc. Transvenous defibrillation lead with side hooks
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
CN1174713C (zh) 1995-08-29 2004-11-10 光谱股份有限公司 用于输药及检测的人体皮肤微穿孔设备
US5682233A (en) 1995-09-08 1997-10-28 Integ, Inc. Interstitial fluid sampler
ATE234129T1 (de) * 1996-06-18 2003-03-15 Alza Corp Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
AU3880697A (en) 1996-07-03 1998-01-21 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
DE69718495T2 (de) * 1996-09-17 2003-11-20 Deka Products Lp System zur medikamentenabgabe durch transport
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
CN1170603C (zh) * 1997-12-11 2004-10-13 阿尔扎有限公司 增强透皮物剂流量的装置
WO1999029364A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
DK1037687T3 (da) * 1997-12-11 2009-01-26 Alza Corp Anordning til at forbedre et middels transdermale strömning
US6022316A (en) * 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
KR20030068137A (ko) * 2000-10-13 2003-08-19 알자 코포레이션 충격 어플리케이터용 미세 돌기 부재 리테이너
MXPA03003299A (es) * 2000-10-13 2004-12-13 Johnson & Johnson Aparato y metodo para perforacion de la piel con microsalientes.
AU9682701A (en) * 2000-10-13 2002-04-22 Alza Corp Microblade array impact applicator
EP2085109A3 (de) * 2000-10-26 2009-09-02 Alza Corporation Transdermale Arzneimittelverabreichungsvorrichtungen mit beschichteten Mikrovorsprüngen
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
JP2004528900A (ja) * 2001-04-20 2004-09-24 アルザ・コーポレーシヨン 有益な作用物質を含有するコーティングを有する微小突起アレイ
AU2002352978A1 (en) * 2001-11-30 2003-06-17 Alza Corporation Methods and apparatuses for forming microprojection arrays
RU2314760C2 (ru) * 2001-12-20 2008-01-20 Алза Корпорейшн Микровыступы, пробивающие кожу, имеющие средство регулирования глубины пробивки
EP1554938B1 (de) * 2002-06-14 2007-07-18 OGAWA & CO., LTD. Inhibitor gegen geschmacksbeeinträchtigung und inhibitor gegen die erzeugung eines durch citralbeeinträchtigung entstehenden geruchs
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CA2543280A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
AU2004287414B2 (en) * 2003-10-31 2010-11-25 Alza Corporation Self-actuating applicator for microprojection array
CN100548228C (zh) * 2003-11-13 2009-10-14 阿尔扎公司 用于透皮递送的组合物和装置
AU2005244734A1 (en) * 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2006079019A2 (en) * 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stabitity containing at least one counterion
EP1843811A2 (de) * 2005-01-31 2007-10-17 Alza Corporation, Inc. Beschichtete mikroprojektionen mit reduzierter variabilität und herstellungsverfahren dafür
TW200640519A (en) * 2005-02-16 2006-12-01 Alza Corp Microprojection arrays with improved biocompatibility
US8374997B2 (en) * 2005-05-20 2013-02-12 Teradota Us, Inc. Application code generation and execution with bypass, logging, user restartability and status functionality
EP1888126A1 (de) * 2005-06-02 2008-02-20 Alza Corporation Verfahren zur endsterilisierung von vorrichtungen zur transdermalen verabreichung
US20070009587A1 (en) * 2005-06-21 2007-01-11 Peter Daddona Method and device for coating a continuous strip of microprojection members

Also Published As

Publication number Publication date
ES2195151T3 (es) 2003-12-01
CA2253549A1 (en) 1997-12-24
WO1997048442A1 (en) 1997-12-24
DE69730973T2 (de) 2005-11-17
JP2001507947A (ja) 2001-06-19
DK0917483T3 (da) 2005-02-07
AR012859A2 (es) 2000-11-22
AU3493397A (en) 1998-01-07
ATE234129T1 (de) 2003-03-15
PT917483E (pt) 2005-01-31
AR008242A1 (es) 1999-12-29
DE69719761D1 (de) 2003-04-17
US6230051B1 (en) 2001-05-08
DK0914178T3 (da) 2003-04-22
AU3399197A (en) 1998-01-07
JP4012252B2 (ja) 2007-11-21
CA2253471C (en) 2007-10-30
EP0917484A1 (de) 1999-05-26
EP0917483A1 (de) 1999-05-26
ES2230614T3 (es) 2005-05-01
DE69730973D1 (de) 2004-11-04
ZA975326B (en) 1998-01-14
ATE277670T1 (de) 2004-10-15
ATE277671T1 (de) 2004-10-15
EP0917483B1 (de) 2004-09-29
EP0914178B1 (de) 2003-03-12
EP0917484B1 (de) 2004-09-29
CA2253549C (en) 2005-10-25
AU3572597A (en) 1998-01-07
JP2000512529A (ja) 2000-09-26
CA2257217C (en) 2006-03-07
WO1997048440A1 (en) 1997-12-24
JP3847790B2 (ja) 2006-11-22
JP2001505444A (ja) 2001-04-24
TW349872B (en) 1999-01-11
CA2257217A1 (en) 1997-12-24
PT917484E (pt) 2004-12-31
DK0917484T3 (da) 2005-02-07
DE69730971T2 (de) 2005-11-17
US6537264B1 (en) 2003-03-25
US6219574B1 (en) 2001-04-17
CA2253471A1 (en) 1997-12-24
WO1997048441A1 (en) 1997-12-24
US20020016562A1 (en) 2002-02-07
EP0914178A1 (de) 1999-05-12
DE69719761T2 (de) 2003-12-18
US7184826B2 (en) 2007-02-27
ES2230611T3 (es) 2005-05-01
US20070118070A1 (en) 2007-05-24
JP2007260436A (ja) 2007-10-11

Similar Documents

Publication Publication Date Title
DE69719761T2 (de) Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
DE69122494D1 (de) Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
AT384737B (de) Vorrichtung zur stroemungskonstanten abgabe fluessiger arzneimittel
DE69325572D1 (de) Gerät und einheit zur dosierung von medikamenten und zur sammlung von körperflüssigkeiten
DE68907769T2 (de) Vorrichtung zum schutz und zur verabreichung von fluessigkeitsempfindlichen arzneimitteln.
DE69118526D1 (de) Mittel zur transdermalen penetration von arzneimitteln
DE3588190D1 (de) Vorrichtung zur transdermalen Applikation von Medikamenten
DE69203990T2 (de) Einrichtung zur transdermalen Verabreichung von Medikamenten.
DE3689935D1 (de) Vorrichtung und verfahren zur erhöhung der haltbarkeit von flüssigen nährmitteln.
DE3850512T2 (de) Verfahren und Vorrichtung zur Feststellung von bitteren oder riechenden Stoffen.
DE3850164T2 (de) Verfahren und Gerät zur Drehwinkelerkennung.
DE69513672T2 (de) Verbesserte vorrichtung zur iontophoretischen verabreichung von medikamenten
DE69218334T2 (de) Vorrichtung zur Wahrnehmung und Identifizierung von Hubschraubern
DE59500266D1 (de) Transdermales therapeutisches System zur Applikation von Naloxon
DE68921691D1 (de) Vorrichtung zum Nachweis und zur Erkennung von Farbe.
ATE292457T1 (de) Mittel und verfahren zur transdermalen verabreichung säurelabiler arzneistoffe
DE68902105D1 (de) Vorrichtung zur gleichmaessigen abgabe von arzneimitteln fuer veterinaere anwendung.
DE69715747D1 (de) Vorrichtung zum Befüllen und zum Verabreichen des Inhalts von Spritzen
DE9409784U1 (de) Vorrichtung zur transdermalen Applikation von Wirkstoffen
DE59711890D1 (de) Gerät zur instillation oder injektion von arzneimitteln
DE29508249U1 (de) Vorrichtung zum Verabreichen von medizinischen Flüssigkeiten
DE9305831U1 (de) Vorrichtung zur Erkennung und Ortung von Notrufen
DE69810442D1 (de) Anordnung zur verabreichung von medikamenten
ATE40517T1 (de) Vorrichtung zur erfassung und verbesserung der funktionsfaehigkeit des bewegungsapparates des menschen.
DE59510773D1 (de) Vorrichtung zur Effektivitätserkennung von Herzreizimpulsen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition