US2619962A - Vaccination appliance - Google Patents

Vaccination appliance Download PDF

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Publication number
US2619962A
US2619962A US947748A US2619962A US 2619962 A US2619962 A US 2619962A US 947748 A US947748 A US 947748A US 2619962 A US2619962 A US 2619962A
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Prior art keywords
vaccination
appliance
skin
disk
needles
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Rosenthal Sol Roy
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Research Foundation of State University of New York
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Research Foundation of State University of New York
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices

Description

Dec. 2, 1952 s. R. ROSENTHAL VACCINATION APPLIANCE Filed Feb. 19, 1948 IN V EN TOR. 1 2

Patented Dec. 2, 1952 VACCINATION APPLIANCE Sol Roy Rosenthal, Chic search Foundation,

ago, 111., assignor to Re- Chicago, 111., a nonprofit corporation of Illinois Application February 19, 1948, Serial No. 9,477

4 Claims.

This invention relates to vaccination appliance and a method of vaccination and its purpose is to provide a new method of vaccination involving the use of an improved device capable of producing a plurality of punctures quickly and simultaneously.

It has heretofore been the common practice to vaccinate with various antigens by inoculating with a syringe and an injecting needle intracutaneously, subcutaneously, or intramuscularly. For smallpox vaccination the virus is introduced percutaneously by placing a layer of the liquid on the skin and puncturing through the vaccine into the skin with a sewing type needle over a small area, usually about oneeighth of an inch 04,) in diameters Because of the concentration of the vaccine in a relatively small area, this prior method has led to either generalized Or localized reactions, sometimes of a severe character. It has been discovered, as a part of the present invention that by introducing a vaccine, for example, the vaccine of Calmette and Guerin, commonly known as BCG, into the skin percutaneously by multiple punctures distributed over a large area, 3 centimeters by 2 centimeters or more, all complications are avoided and the immunization produced is of a high order. However, the execution of a multiplicity of punctures with the use of a single needle consumes a great deal of time and there is a protracted irritation of the patient which is objectionable, particularly in the case of a child.

It is, therefore, the principal object of the present invention to provide an instrument which may be conveniently employed to form an adequate number of punctures of the skin conveniently and simultaneously, thus saving a considerable amount of time and limiting the irritation of the patient to a brief interval. A further object of the invention is to provide a vaccination appliance in the form of a disk preferably shaped to conform substantially to the contour of the skin and having a plurality of spikes or needles projecting from one face thereof so that a large number of punctures of the skin may be made merely by pressing the disk against the skin. Another object of the invention is to provide a vaccination device comprising a thin metal plate having a plurality of spikes or needles punched therefrom on one side to form a simple and inexpensive appliance which may be discarded after use. Other objects relate to various features and details of construction which will appear more fully hereinafter.

The nature of the invention will be understood from the following specification taken with the accompanying drawings in which one embodiment is illustrated. In the drawings,

Figure 1 shows a perspective view of the vaccination appliance of the present invention applied to the arm of a patient in the process of vaccination;

Fig. 2 shows a top plan view of the vaccination appliance illustrated in Fig. 1;

Fig. 3 shows a bottom plan view of the vaccination appliances illustrated in Fig. 1; and

Fig. 4 shows a transverse vertical section taken on the line 44 of Fig. 2.

As illustrated in the drawings, the invention is embodied in a metal disk I 0 provided with two oppositely directed arms I 0a which may serve as handles during the use of the appliance. The disk In is preferably very thin, for example, about 0.2 millimeter in thickness, and its diameter may be about 4 cms. which is sufficient for vaccination purposes. The disk I0 is preferably curved slightly to conform to the curvature of the surface of the arm or leg of the patient so that it will lie in contact with the skin throughout its area when used.

This metal disk In is provided with a plurality of pointed spikes or needles Illb which extend downwardly or inwardly from one side of the disk or plate in the same direction and to the same extent. These spikes or needles are preferably from 1 to 2 mms. in length. They may be formed by punching out the metal of the disk to form apertures I00 and bending the punched metal inwardly or downwardly at right angles to the plane of the plate to form the spikes which are preferably ground off so that they are sharply pointed, as distinguished from having a knifeedged formation. In punching the apertures I00 and the corresponding spikes or needles I 0?), the punchings are preferably arranged in concentric circular rows as shown in Figs. 2 and 3, the rows being approximately 4 mms. apart and the spikes of each row being spaced approximately 4 mms. from each other.

In Fig. 1 of the drawings, the vaccination appliance illustrated in Figs. 2, 3 and 4 is shown applied to the arm II of the patient in the process of vaccination. In carrying on this process,-

the surface of the skin is first cleaned with alcoappliance I0 is placed which the vaccine has pressed inwardly, thereby forming a plurality of punctures of the skin with a resulting injection of the vaccine at the site of each of the spikes or needles b. In this way, the punctures of the skin are all effected simultaneously and are of equal depth so that there is a uniformity of effect throughout the area of the vaccination, in addition to which there is a great saving of time as compared with former practice and the advantage that the irritation of the patient exists only for an instant. With the use of the embodiment of the invention shown, the fingers l2 of the operator are shown as pressing on the arms 10a of the device in the act of effecting the punctures but, if desired, the arms We may be eliminated and the punctures may be effected by pressing directly upon the outer face of the metal disk. A great advantage of the present invention is that the vaccination appliance is a disposable one which may be discarded after use so that there is no necessity for resterilization and no danger of infection in the treatment of successive patients,

Although the vaccine may be in the usual liquid form, the present invention may be used with great advantage when employing a vaccine having the dry or powder form which is described and claimed in my copending application, Serial No, 9,476, filed February 19, 1948.

The vaccination appliance of the present invention has been found effective and successful in the vaccination of human beings and guinea pigs employing the tuberculosis vaccine of Calmette and Guerin, commonly known as ECG, and also with the use of pertussis and smallpox vaccines.

Although one form of the invention has been shown and described by way of illustration, it will be understood that it may be constructed in various other embodiments which come within the scope of the appended claims.

I claim:

1. A vaccination appliance comprising a thin metal plate having needles punched therefrom and projecting in parallel relationship from one side thereof outwardly beyond the level of all adjacent surfaces on said plate.

2. A vaccination appliance comprising a thin metal plate having needles punched therefrom in concentric rows, with the needles substantially uniformly spaced in each row and projecting outwardly beyond the level of all adjacent surfaces on said plate.

3. A vaccination appliance comprising a thin metal disk slightly curved to conform to the curvature of the skin surface of a human arm or leg, said disk having a plurality of substantially uniformly spaced needles punched therefrom and projecting from the concave surface thereof.

4. A vaccination appliance comprisin a thin metal disk slightly curved to conform to the curvature of the skin surface of a human arm or leg, said disk having a plurality of substantially uniformly spaced needles, on the order of from one to two millimeters in length, punched therefrom and projecting from the concave surface thereof.

SOL ROY ROSENTHAL.

REFERENCES CITED The following references are of record in the file of this patent:

UNITED STATES PATENTS 4 Price Aug. 24, 1948

US2619962A 1948-02-19 1948-02-19 Vaccination appliance Expired - Lifetime US2619962A (en)

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Cited By (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2801633A (en) * 1954-02-17 1957-08-06 Joseph C Ehrlich Lancets
US2817336A (en) * 1952-12-20 1957-12-24 Kravitz Harvey Means for vaccinating
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3062212A (en) * 1960-08-08 1962-11-06 Kravitz Harvey Vaccinating devices
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3074403A (en) * 1960-05-17 1963-01-22 American Cyanamid Co Intracutaneous injector with capillary gap
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
DE1195430B (en) * 1960-08-01 1965-06-24 Harvey Kravitz Apparatus for transferring a biological substance into the skin tissue
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3351059A (en) * 1964-06-02 1967-11-07 Norman Lettvin Single stable dose vaccinator
US3866597A (en) * 1973-09-04 1975-02-18 Steve Boxer Process and device for alleviation of non-muscular pain
US3886939A (en) * 1973-09-04 1975-06-03 Steve Boxer Device for alleviating muscular discomfort
WO2002002179A1 (en) * 2000-06-29 2002-01-10 Becton, Dickinson And Company Microneedle for delivering a substance into the dermis
WO2002007813A1 (en) * 2000-07-21 2002-01-31 Smithkline Beecham Biologicals S.A. Vaccines
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20020128599A1 (en) * 2000-10-26 2002-09-12 Cormier Michel J.N. Transdermal drug delivery devices having coated microprotrusions
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US20030181936A1 (en) * 2001-12-20 2003-09-25 Trautman Joseph C. Skin-piercing microprojections having piercing depth control
US20030199810A1 (en) * 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
US20040023844A1 (en) * 2002-05-06 2004-02-05 Pettis Ronald J. Method and device for controlling drug pharmacokinetics
US20040028707A1 (en) * 2001-06-29 2004-02-12 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
US20040062813A1 (en) * 2002-06-28 2004-04-01 Cormier Michel J. N. Transdermal drug delivery devices having coated microprotrusions
US20040096455A1 (en) * 2002-08-08 2004-05-20 Yuh-Fun Maa Transdermal vaccine delivery device having coated microprotrusions
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
US20050031676A1 (en) * 2003-08-04 2005-02-10 Wong Patrick S.L. Method and device for enhancing transdermal agent flux
US20050049625A1 (en) * 2003-08-26 2005-03-03 Steven Shaya Device and method for intradermal cell implantation
US20050055010A1 (en) * 2002-05-06 2005-03-10 Pettis Ronald J. Method for altering insulin pharmacokinetics
US20050106227A1 (en) * 2003-10-28 2005-05-19 Samuel Zalipsky Delivery of polymer conjugates of therapeutic peptides and proteins via coated microprojections
US20050163711A1 (en) * 2003-06-13 2005-07-28 Becton, Dickinson And Company, Inc. Intra-dermal delivery of biologically active agents
US20050180952A1 (en) * 2003-08-26 2005-08-18 Pettis Ronald J. Methods for intradermal delivery of therapeutics agents
US20050256182A1 (en) * 2004-05-11 2005-11-17 Sutter Diane E Formulations of anti-pain agents and methods of using the same
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060051403A1 (en) * 2004-09-08 2006-03-09 James Matriano Microprojection array with improved skin adhesion and compliance
US20060074377A1 (en) * 2001-04-20 2006-04-06 Cormier Michel J Microprojection array immunization patch and method
US20070184096A1 (en) * 2005-12-28 2007-08-09 Alza Corporation Stable Therapeutic Formulations
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
JP2007260436A (en) * 1996-06-18 2007-10-11 Alza Corp Apparatus for enhancing medical agent percutaneous discharge or sampling
US20080102192A1 (en) * 2004-11-18 2008-05-01 Johnson Peter R Masking Method for Coating a Microneedle Array
US20080118465A1 (en) * 2001-04-13 2008-05-22 Pettis Ronald J Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
US7473247B2 (en) 1999-10-14 2009-01-06 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US7556821B2 (en) 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US7579013B2 (en) 2003-06-30 2009-08-25 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
US8414959B2 (en) 2004-11-18 2013-04-09 3M Innovative Properties Company Method of contact coating a microneedle array
US8900194B2 (en) 2002-07-19 2014-12-02 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34677A (en) * 1862-03-18 Dermopathic instrument
US60917A (en) * 1867-01-01 Anson r
US84854A (en) * 1868-12-15 Improved instrument for acupuncturation
US505818A (en) * 1893-10-03 Alexander dallas
US1212927A (en) * 1916-08-16 1917-01-16 Thomas Arthur Flood Vaccinating device.
US1467231A (en) * 1921-06-01 1923-09-04 Cox Frederick Nutter Surgical tool
US1600908A (en) * 1925-06-09 1926-09-21 Goodyear Tire & Rubber Container for rubber repair material
US2131284A (en) * 1937-06-28 1938-09-27 Isturiz Jesus Maria Vaccinating method and means
US2447596A (en) * 1947-06-03 1948-08-24 Foster S Price Vaccination device

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34677A (en) * 1862-03-18 Dermopathic instrument
US60917A (en) * 1867-01-01 Anson r
US84854A (en) * 1868-12-15 Improved instrument for acupuncturation
US505818A (en) * 1893-10-03 Alexander dallas
US1212927A (en) * 1916-08-16 1917-01-16 Thomas Arthur Flood Vaccinating device.
US1467231A (en) * 1921-06-01 1923-09-04 Cox Frederick Nutter Surgical tool
US1600908A (en) * 1925-06-09 1926-09-21 Goodyear Tire & Rubber Container for rubber repair material
US2131284A (en) * 1937-06-28 1938-09-27 Isturiz Jesus Maria Vaccinating method and means
US2447596A (en) * 1947-06-03 1948-08-24 Foster S Price Vaccination device

Cited By (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
US2817336A (en) * 1952-12-20 1957-12-24 Kravitz Harvey Means for vaccinating
US2801633A (en) * 1954-02-17 1957-08-06 Joseph C Ehrlich Lancets
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3074403A (en) * 1960-05-17 1963-01-22 American Cyanamid Co Intracutaneous injector with capillary gap
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
DE1195430B (en) * 1960-08-01 1965-06-24 Harvey Kravitz Apparatus for transferring a biological substance into the skin tissue
US3062212A (en) * 1960-08-08 1962-11-06 Kravitz Harvey Vaccinating devices
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3351059A (en) * 1964-06-02 1967-11-07 Norman Lettvin Single stable dose vaccinator
US3866597A (en) * 1973-09-04 1975-02-18 Steve Boxer Process and device for alleviation of non-muscular pain
US3886939A (en) * 1973-09-04 1975-06-03 Steve Boxer Device for alleviating muscular discomfort
JP2007260436A (en) * 1996-06-18 2007-10-11 Alza Corp Apparatus for enhancing medical agent percutaneous discharge or sampling
US7473247B2 (en) 1999-10-14 2009-01-06 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20050124967A1 (en) * 1999-10-14 2005-06-09 Kaestner Scott A. Method and device for delivery of high molecular weight substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US20030100885A1 (en) * 1999-10-14 2003-05-29 Pettis Ronald J. Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
US20050096631A1 (en) * 2000-06-29 2005-05-05 Pettis Ronald J. Intradermal delivery of substances
US8986280B2 (en) 2000-06-29 2015-03-24 Becton, Dickinson And Company Intradermal delivery of substances
US8708994B2 (en) 2000-06-29 2014-04-29 Becton, Dickinson And Company Method for altering drug pharmacokinetics based on medical delivery platform
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20110190725A1 (en) * 2000-06-29 2011-08-04 Becton, Dickinson And Company Method for altering drug pharmacokinetics based on medical delivery platform
US8998877B2 (en) 2000-06-29 2015-04-07 Becton, Dickinson And Company Intradermal delivery of substances
EP1925333A1 (en) * 2000-06-29 2008-05-28 Becton, Dickinson and Company Intradermal delivery of substances
EP1880743A1 (en) * 2000-06-29 2008-01-23 Becton, Dickinson and Company Microneedle for delivering a substance into the dermis
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US9005182B2 (en) 2000-06-29 2015-04-14 Becton, Dickinson And Company Intradermal delivery of substances
US9242052B2 (en) 2000-06-29 2016-01-26 Becton, Dickinson And Company Method for altering drug pharmacokinetics based on medical delivery platform
WO2002002179A1 (en) * 2000-06-29 2002-01-10 Becton, Dickinson And Company Microneedle for delivering a substance into the dermis
US20050096632A1 (en) * 2000-06-29 2005-05-05 Pettis Ronald J. Intradermal delivery of substances
US20050096630A1 (en) * 2000-06-29 2005-05-05 Pettis Ronald J. Intradermal delivery of substances
US9339613B2 (en) 2000-06-29 2016-05-17 Becton, Dickinson And Company Intradermal delivery of substances
US20050197308A1 (en) * 2000-07-21 2005-09-08 Smithkline Beecham Biologicals S.A. Vaccines
EP1512429A1 (en) * 2000-07-21 2005-03-09 SMITHKLINE BEECHAM BIOLOGICALS s.a. Needles coated with vaccine
WO2002007813A1 (en) * 2000-07-21 2002-01-31 Smithkline Beecham Biologicals S.A. Vaccines
US20040049150A1 (en) * 2000-07-21 2004-03-11 Dalton Colin Cave Vaccines
US7537795B2 (en) 2000-10-26 2009-05-26 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US20020128599A1 (en) * 2000-10-26 2002-09-12 Cormier Michel J.N. Transdermal drug delivery devices having coated microprotrusions
US20080118465A1 (en) * 2001-04-13 2008-05-22 Pettis Ronald J Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
US20090143724A1 (en) * 2001-04-20 2009-06-04 Alza Corporation Microprojection Array Immunization Patch and Method
US20060074377A1 (en) * 2001-04-20 2006-04-06 Cormier Michel J Microprojection array immunization patch and method
US20040028707A1 (en) * 2001-06-29 2004-02-12 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
US20080118507A1 (en) * 2001-06-29 2008-05-22 Pettis Ronald J Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
US20080119392A1 (en) * 2001-06-29 2008-05-22 Pettis Ronald J Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
US20080138286A1 (en) * 2001-06-29 2008-06-12 Pettis Ronald J Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US20030199810A1 (en) * 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
US20030181936A1 (en) * 2001-12-20 2003-09-25 Trautman Joseph C. Skin-piercing microprojections having piercing depth control
US20100262120A1 (en) * 2002-05-06 2010-10-14 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
US9192750B2 (en) 2002-05-06 2015-11-24 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
US20040023844A1 (en) * 2002-05-06 2004-02-05 Pettis Ronald J. Method and device for controlling drug pharmacokinetics
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
US7722595B2 (en) 2002-05-06 2010-05-25 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
US20050055010A1 (en) * 2002-05-06 2005-03-10 Pettis Ronald J. Method for altering insulin pharmacokinetics
US20040062813A1 (en) * 2002-06-28 2004-04-01 Cormier Michel J. N. Transdermal drug delivery devices having coated microprotrusions
US8900194B2 (en) 2002-07-19 2014-12-02 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US20040096455A1 (en) * 2002-08-08 2004-05-20 Yuh-Fun Maa Transdermal vaccine delivery device having coated microprotrusions
US20050163711A1 (en) * 2003-06-13 2005-07-28 Becton, Dickinson And Company, Inc. Intra-dermal delivery of biologically active agents
US7579013B2 (en) 2003-06-30 2009-08-25 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
US20050031676A1 (en) * 2003-08-04 2005-02-10 Wong Patrick S.L. Method and device for enhancing transdermal agent flux
US20050049625A1 (en) * 2003-08-26 2005-03-03 Steven Shaya Device and method for intradermal cell implantation
US20050180952A1 (en) * 2003-08-26 2005-08-18 Pettis Ronald J. Methods for intradermal delivery of therapeutics agents
US20050106227A1 (en) * 2003-10-28 2005-05-19 Samuel Zalipsky Delivery of polymer conjugates of therapeutic peptides and proteins via coated microprojections
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
US20050256182A1 (en) * 2004-05-11 2005-11-17 Sutter Diane E Formulations of anti-pain agents and methods of using the same
US8361022B2 (en) 2004-05-13 2013-01-29 Alza Corporation Apparatus for transdermal delivery of parathyroid hormone agents
US7556821B2 (en) 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060051403A1 (en) * 2004-09-08 2006-03-09 James Matriano Microprojection array with improved skin adhesion and compliance
US8414959B2 (en) 2004-11-18 2013-04-09 3M Innovative Properties Company Method of contact coating a microneedle array
US20080102192A1 (en) * 2004-11-18 2008-05-01 Johnson Peter R Masking Method for Coating a Microneedle Array
US8741377B2 (en) 2004-11-18 2014-06-03 3M Innovative Properties Company Method of contact coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
US7846488B2 (en) 2004-11-18 2010-12-07 3M Innovative Properties Company Masking method for coating a microneedle array
US20070184096A1 (en) * 2005-12-28 2007-08-09 Alza Corporation Stable Therapeutic Formulations
US8632801B2 (en) 2005-12-28 2014-01-21 Alza Corporation Stable therapeutic formulations

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