DE68921760D1 - Behandlung von beschädigtem knochenmark und dosierungseinheiten dafür. - Google Patents

Behandlung von beschädigtem knochenmark und dosierungseinheiten dafür.

Info

Publication number
DE68921760D1
DE68921760D1 DE68921760T DE68921760T DE68921760D1 DE 68921760 D1 DE68921760 D1 DE 68921760D1 DE 68921760 T DE68921760 T DE 68921760T DE 68921760 T DE68921760 T DE 68921760T DE 68921760 D1 DE68921760 D1 DE 68921760D1
Authority
DE
Germany
Prior art keywords
pharmaceutically acceptable
damage
aliphatic
substituted
bone marrow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68921760T
Other languages
English (en)
Inventor
Richard Borch
Therese Schmalbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
Original Assignee
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Rochester filed Critical University of Rochester
Application granted granted Critical
Publication of DE68921760D1 publication Critical patent/DE68921760D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polishing Bodies And Polishing Tools (AREA)
  • Magnetic Heads (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
DE68921760T 1988-09-12 1989-09-12 Behandlung von beschädigtem knochenmark und dosierungseinheiten dafür. Expired - Lifetime DE68921760D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/243,405 US4938949A (en) 1988-09-12 1988-09-12 Treatment of damaged bone marrow and dosage units therefor
PCT/US1989/003941 WO1990002550A1 (en) 1988-09-12 1989-09-12 Treatment of damaged bone marrow and dosage units therefor

Publications (1)

Publication Number Publication Date
DE68921760D1 true DE68921760D1 (de) 1995-04-20

Family

ID=22918655

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68921760T Expired - Lifetime DE68921760D1 (de) 1988-09-12 1989-09-12 Behandlung von beschädigtem knochenmark und dosierungseinheiten dafür.

Country Status (9)

Country Link
US (1) US4938949A (de)
EP (1) EP0433393B1 (de)
JP (1) JPH04500676A (de)
AT (1) ATE119771T1 (de)
AU (1) AU623184B2 (de)
DE (1) DE68921760D1 (de)
DK (1) DK44791A (de)
NZ (1) NZ230622A (de)
WO (1) WO1990002550A1 (de)

Families Citing this family (608)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187193A (en) * 1988-09-12 1993-02-16 University Of Rochester Method for stimulating transplanted bone marrow cells
AU6647190A (en) * 1989-10-10 1991-05-16 University Of Rochester Method for producing bone marrow growth cell factors
JPH06509578A (ja) * 1991-07-26 1994-10-27 ユニバーシティ・オブ・ロチェスター 悪性細胞利用による癌治療法
US5240914A (en) * 1992-02-03 1993-08-31 Adolph Schwimmer Method and compositions for inhibiting tumor cell metabolism
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
JP4259611B2 (ja) 1994-08-29 2009-04-30 ウェイク フォレスト ユニバーシティ ウィルス感染を治療するための脂質アナログ
US5807874A (en) * 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5767142A (en) * 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5616575A (en) * 1995-12-04 1997-04-01 Regents Of The University Of Minnesota Bioactive tricyclic ibogaine analogs
US5932553A (en) 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US5723632A (en) 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
US5922761A (en) * 1996-09-06 1999-07-13 Medinox, Inc. Methods for in vivo reduction of iron levels and compositions useful therefor
NZ334954A (en) * 1996-09-23 2000-08-25 Univ Rutgers Substituted heterocycles as anti-tumor agents
US5916903A (en) * 1997-02-28 1999-06-29 Synapse Pahrmaceuticals International, Inc. Method for reducing the effects of antineoplastic disease treatment
US5866558A (en) * 1997-05-08 1999-02-02 Regents Of The University Of Minnesota 6-alkynyl steroids
US6486214B1 (en) * 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US6140328A (en) * 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
JP3866298B2 (ja) * 1997-12-29 2007-01-10 リサーチ コーポレイション テクノロジーズ,インコーポレイティド β−ラクタマーゼインヒビターとしての2β−置換化−6−アルキリデンペニシラン酸誘導体
US6051603A (en) * 1998-01-20 2000-04-18 Wayne Hughes Institute Vanadium (IV) metallocene complexes having sperm motility inhibiting activity
US6245808B1 (en) 1998-11-05 2001-06-12 Parker Hughes Institute Oxy-vanadium (IV) complexes having spermicidal activity
US6432941B1 (en) * 1998-01-20 2002-08-13 Parker Hughes Institute Vanadium compounds for treating cancer
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
US7141603B2 (en) * 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
US6025328A (en) 1998-02-20 2000-02-15 The Regents Of The University Of California Antitumor agents
US6117878A (en) * 1998-02-24 2000-09-12 University Of Virginia 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors
US6355678B1 (en) * 1998-06-29 2002-03-12 Parker Hughes Institute Inhibitors of the EGF-receptor tyrosine kinase and methods for their use
US6800649B1 (en) 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
US6323190B1 (en) 1998-07-31 2001-11-27 The Univeristy Of Georgia Research Foundation, Inc. Estrogen mimetics lacking reproductive tract effects
US7214665B2 (en) * 2001-10-01 2007-05-08 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
US7378400B2 (en) * 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US7427606B2 (en) * 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US6166003A (en) * 1999-02-17 2000-12-26 Lkt Laboratories, Inc. Heterocyclic compounds for cancer chemoprevention
US6638518B1 (en) 1999-02-22 2003-10-28 University Of Iowa Research Foundation Method for inhibiting inflammatory responses
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
DK1159279T3 (da) 1999-03-09 2003-02-17 Upjohn Co 4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler
US6258820B1 (en) 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US7064114B2 (en) * 1999-03-19 2006-06-20 Parker Hughes Institute Gel-microemulsion formulations
US6306897B1 (en) 1999-03-19 2001-10-23 Parker Hughes Institute Calanolides for inhibiting BTK
US6407091B1 (en) * 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
US6930101B1 (en) 1999-05-17 2005-08-16 The Regents Of The University Of California Thiazolopyrimidines useful as TNFα inhibitors
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
AU5630800A (en) * 1999-06-22 2001-01-09 Arno F Spatola Antimicrobial agents
US6946458B2 (en) 1999-07-22 2005-09-20 University Of South Florida N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus
US7151100B1 (en) * 1999-07-23 2006-12-19 The Regents Of The University Of California Indole compounds useful for the treatment of cancer
US6852685B1 (en) 1999-08-17 2005-02-08 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof to promote neuronal cell differentiation
US7119064B2 (en) * 1999-08-17 2006-10-10 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof as modulators of intracellular signaling molecules
EP1218018A4 (de) * 1999-08-17 2005-06-01 Univ Texas Verwendung von colostrinin, seine peptidbestandteile und ihre analogen als regulatoren bei oxidativem stress
US6903068B1 (en) 1999-08-17 2005-06-07 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines
MY125942A (en) 1999-09-07 2006-09-29 Upjohn Co Aminoalkoxy carbazoles for the treatment of cns diseases
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
US6670341B1 (en) 1999-10-28 2003-12-30 Wake Forest University Health Sciences Compositions and methods for double-targeting virus infections and targeting cancer cells
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
AU1608801A (en) 1999-11-15 2001-05-30 Parker Hughes Institute Diamino platinum (ii) antitumor complexes
US6649654B1 (en) 1999-11-23 2003-11-18 The Regents Of The University Of California Methods for identifying and using IKK inhibitors
US6589992B2 (en) 1999-11-30 2003-07-08 Parker Hughes Institute Inhibiting collagen-induced platelet aggregation
US20040038948A1 (en) 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
US6685928B2 (en) 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
ATE316097T1 (de) * 2000-01-20 2006-02-15 Univ Minnesota Peptide mit antibakterieller wirkung
JP2003529601A (ja) 2000-03-21 2003-10-07 ファルマシア・アンド・アップジョン・カンパニー 抗ウイルス剤としての4−オキソ−1,4−ジヒドロ[1,8]ナフチリジン−3−カルボキサミド
MXPA02009250A (es) 2000-03-21 2003-03-12 Upjohn Co 4-hidroxi-1,8-naftiridin--3-carboxamidas como agentes antivirales.
WO2001081318A1 (en) 2000-03-21 2001-11-01 Pharmacia & Upjohn Company 4-hydroxycinnoline-3-carboxyamides as antiviral agents
US6682892B2 (en) 2000-07-13 2004-01-27 Pharmacia & Upjohn Company Method for treating herpes viruses
US20040152672A1 (en) * 2000-08-09 2004-08-05 Carson Dennis A. Indole compounds useful for the treatment of cancer
US6696441B1 (en) 2000-08-11 2004-02-24 The Regents Of The University Of California Inhibition of p53-induced stress response
WO2002026762A1 (en) * 2000-09-29 2002-04-04 Regents Of The University Of Minnesota Triterpenes having antibacterial activity
US6951847B2 (en) * 2000-09-29 2005-10-04 Regents Of The University Of Minnesota Methods of treating fungal infections using lupeol
US6642217B2 (en) 2000-09-29 2003-11-04 Naturtek, Llc Triterpenes having human antifungal and antiyeast activity
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
US6878388B1 (en) 2000-11-15 2005-04-12 Parker Hughes Institute Vanadium compounds for treating proliferative cell disorders
US6642221B1 (en) 2000-11-15 2003-11-04 Parker Hughes Institute Vanadium compounds as anti-proliferative agents
US6958359B1 (en) * 2000-11-15 2005-10-25 Parker Hughes Institute Vanadium compounds as anti-angiogenic agents
AU2002249885A1 (en) 2000-11-17 2002-08-12 Adolor Corporation Delta agonist analgesics
US20040034045A1 (en) * 2000-11-29 2004-02-19 Parker Hughes Institute Inhibitors of thrombin induced platelet aggregation
US7261901B2 (en) * 2001-01-31 2007-08-28 University Of Iowa Research Foundation Vaccine and compositions for the prevention and treatment of neisserial infections
US7250172B2 (en) * 2001-01-31 2007-07-31 University Of Iowa Research Foundation Vaccine and compositions for the prevention and treatment of neisserial infections
US6703524B2 (en) 2001-02-20 2004-03-09 Lkt Laboratories, Inc. Organoselenium compounds for cancer chemoprevention
US7232829B2 (en) * 2001-04-06 2007-06-19 Regents Of The University Of Minnesota Therapeutic compounds and methods
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
CN1486289A (zh) * 2001-05-29 2004-03-31 皇家菲利浦电子有限公司 金属-陶瓷的结合
US20030232794A1 (en) * 2001-06-26 2003-12-18 Cottam Howard B. Use of STAT-6 inhibitors as therapeutic agents
US7601846B2 (en) * 2001-06-26 2009-10-13 The Regents Of The University Of California Compounds having activity as inhibitors of apoptosis
JP2005502687A (ja) * 2001-07-24 2005-01-27 アラムクス エルエルシー β−ラクタマーゼ阻害剤としての7−アルキリデン−3−置換型−3−セフェム−4−カルボキシラート
US6753414B2 (en) * 2001-08-07 2004-06-22 University Of Iowa Research Foundation, Inc. Process for preparing saponin compounds
JP2005526691A (ja) 2001-08-08 2005-09-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 治療剤1H−ピリド[4,3−b]インドール
US20030171377A1 (en) * 2001-08-29 2003-09-11 Bigge Christopher Franklin Antidiabetic agents
WO2003020728A1 (en) 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
IL160080A0 (en) * 2001-08-31 2004-06-20 Thomson Licensing Sa Sequence counter for an audio visual stream
BR0212676A (pt) * 2001-09-21 2006-05-23 Upjohn Co compostos terapêuticos ligantes de 5-ht, composições farmacêuticas compreendendo tais compostos e seus usos
US6815555B2 (en) 2001-09-26 2004-11-09 Theravance, Inc. Substituted phenol compounds useful for anesthesia and sedation
WO2003031587A2 (en) * 2001-10-09 2003-04-17 The Regents Of The University Of California Use of stat-6 inhibitors as therapeutic agents
DE60238435D1 (de) * 2001-10-26 2011-01-05 Scripps Research Inst Gezielte thrombose durch gewebefaktor polypeptiden
CA2467774C (en) 2001-11-14 2011-09-20 Rutgers, The State University Solubilized topoisomerase poisons
DE60228484D1 (de) * 2001-11-14 2008-10-02 Univ Rutgers Cytotoxische mittel
MXPA04004701A (es) * 2001-11-23 2005-07-01 Univ Rutgers Sintesis mejorada de polianhidridos.
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
AU2003205332A1 (en) * 2002-01-25 2003-09-02 Philip S. Portoghese Selective analgesic agents
JP2005519928A (ja) * 2002-02-04 2005-07-07 ハース,ベルナー Co放出能力を有する化合物の投与によって哺乳動物を治療する方法と、co放出能力を有する化合物ならびにその医薬組成物
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
CA2475187A1 (en) 2002-02-07 2003-08-14 Rutgers, The State University Of New Jersey Therapeutic polyesters and polyamides
WO2003072053A2 (en) 2002-02-22 2003-09-04 The Curators Of The University Of Missouri Compounds for treatment of copper overload
US20050032713A1 (en) * 2002-03-27 2005-02-10 Wurtman Richard J. Platelet-activating factor antagonists as analgesic, anti-inflammatory, uterine contraction inhibiting, and anti-tumor agents
AU2003224874A1 (en) * 2002-04-04 2003-10-27 Alamx, L.L.C. INHIBITORS OF SERINE AND METALLO-ss-LACTAMASES
JP4651946B2 (ja) * 2002-04-25 2011-03-16 ザ スクリプス リサーチ インスティテュート 肺病態の治療および予防
US7026472B2 (en) * 2002-05-06 2006-04-11 University Of South Florida Methods for preventing and treating cancer using N-thiolated β-lactam compounds and analogs thereof
US20040156799A1 (en) * 2002-06-04 2004-08-12 Zigang Dong Cancer treatment method and compositions
UA79293C2 (en) * 2002-07-03 2007-06-11 Univ Wayne State 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents
WO2004004640A2 (en) * 2002-07-05 2004-01-15 Tetragrammaton Inc. Methods, compositions and kits for treating damage to excitable tissue
US6989387B2 (en) * 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
JP2005538175A (ja) * 2002-09-11 2005-12-15 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー 血液凝固過程に関与する第Xa因子および他セリンプロテアーゼのインヒビター
WO2004026116A2 (en) * 2002-09-19 2004-04-01 The Regents Of The University Of California Use of etodoclac to treat hyperplasia
WO2004032599A2 (en) 2002-10-10 2004-04-22 Cornell Research Foundation, Inc. Novel immunogenic proteins of leptospira
US20060183106A1 (en) * 2002-10-18 2006-08-17 Adam Siddiqui-Jain Processes for identifying quadruplex-targeted antiviral molecules
EP1567551A4 (de) * 2002-10-22 2008-03-12 Univ Texas Colostrinin und darin enthaltende peptide als modulatoren von intrazellulären signal-molekülen und apoptose-inhibitoren
BR0306632A (pt) * 2002-10-28 2004-09-28 Paraquest Inc Hipoestóxidos, seus derivados e agonistas para uso no tratamento e profilaxia de hiperlipidemia
WO2004041865A2 (en) 2002-11-08 2004-05-21 Ablynx N.V. Stabilized single domain antibodies
AU2003286004A1 (en) 2002-11-08 2004-06-07 Ablynx N.V. Single domain antibodies directed against interferon- gamma and uses therefor
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
EP1565165A2 (de) * 2002-11-26 2005-08-24 Gilead Sciences, Inc. Liposomzubereitungen
US8119854B2 (en) * 2002-12-10 2012-02-21 Pietro P. Sanna Role of proteoglycans in drug dependence
EP1581634A4 (de) * 2002-12-10 2006-10-25 Scripps Research Inst Verfahren zur behandlung von drogensucht und zum screening von pharmazeutika dafür
US7297340B2 (en) * 2003-01-07 2007-11-20 University Of Iowa Research Foundation Vaccine and method for preventing biofilm formation
CA2512545C (en) 2003-01-10 2015-06-30 Karen Silence Recombinant vhh single domain antibody from camelidae against von willebrand factor (vwf)
US20050079512A1 (en) * 2003-02-26 2005-04-14 Emerson Beverly M. Methods of modulating gene expression
JP4928937B2 (ja) 2003-03-28 2012-05-09 スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ ミグラスタチンアナログおよびその使用
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
BRPI0409105A (pt) * 2003-04-07 2006-04-25 Cylene Pharmaceuticals Inc análogos de quinobenzoxazina substituìdos
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
US7163948B2 (en) * 2003-04-07 2007-01-16 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs
US20040248880A1 (en) * 2003-04-25 2004-12-09 Jacobsen Eric Jon 1,2,3,4,5,6-Hexahydroazepino[4,5-B]indoles containing arylsulfones at the 9-position
EP1635858A4 (de) * 2003-05-29 2009-08-26 Scripps Research Inst Gezielte abgabe an legumain exprimierende zellen
CA2529507C (en) 2003-06-25 2011-08-09 The Burnham Institute Compounds and methods for inducing apoptosis in cancer cells
WO2005003140A1 (en) * 2003-07-02 2005-01-13 Pharmacia & Upjohn Company Llc 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
EP2295434B1 (de) 2003-08-25 2015-09-30 Dogwood Pharmaceuticals, Inc. Substituierte 8-Heteroaryl-Xanthine
PL2520654T3 (pl) 2003-08-26 2017-08-31 The Regents Of The University Of Colorado, A Body Corporate Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych
US9532994B2 (en) 2003-08-29 2017-01-03 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
US20050118678A1 (en) * 2003-10-17 2005-06-02 Regents Of The University Of Minnesota Modified polypeptides with therapeutic activity and methods of use
EP2251357A1 (de) 2003-11-07 2010-11-17 Ablynx N.V. Camelidae schweren Ketten Antikörpern VHHS gegen Epidermal Growth Faktor Rezeptor (EGFR) und Ihre Verwendungen
WO2005055994A1 (en) * 2003-12-04 2005-06-23 The Scripps Research Institute Treatment and preventions of asthma
EP2299266A1 (de) * 2003-12-19 2011-03-23 The Regents of the University of California Verfahren und Materialien zur Beurteilung von Prostatakrebstherapien
NZ548195A (en) 2004-01-14 2011-01-28 Gilead Sciences Inc Lipid-based dispersions useful for drug delivery
WO2005072766A2 (en) * 2004-01-27 2005-08-11 Boys Town National Research Hospital Peptides that bind to hsp90 proteins
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
US20050187192A1 (en) * 2004-02-20 2005-08-25 Kucera Pharmaceutical Company Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
US7718684B2 (en) * 2004-02-24 2010-05-18 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
EP1737472B1 (de) 2004-03-29 2014-08-13 University Of South Florida Wirksame Behandlung von Tumoren und Krebs mit Triciribin
US8957056B2 (en) * 2004-05-25 2015-02-17 Sloan-Kettering Instiute For Cancer Research Migrastatin analogs in the treatment of cancer
EP1778712B1 (de) * 2004-08-02 2013-01-30 University Of Virginia Patent Foundation 2-propynyl-adenosin-analoga mit modifizierten 5'-ribosegruppen mit a2a-agonistenaktivität
WO2006028618A1 (en) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
US7442687B2 (en) * 2004-08-02 2008-10-28 The University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
WO2006026380A2 (en) * 2004-08-25 2006-03-09 University Of Iowa Research Foundation Geranylgeranyl pyrophosphate synthase inhibitors
JP4950890B2 (ja) * 2004-09-13 2012-06-13 ギリアード サイエンシーズ, インコーポレイテッド 動物に対する鉄の送達
US7718680B2 (en) * 2004-09-23 2010-05-18 Burnham Institute For Medical Research Inhibition of lethal factor protease activity from anthrax toxin
US8188141B2 (en) * 2004-09-23 2012-05-29 Sloan-Kettering Institute For Cancer Research Isomigrastatin analogs in the treatment of cancer
CA2583017A1 (en) * 2004-10-13 2006-04-20 Ablynx N.V. Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenerative neural diseases such as alzheimer's disease
US8697674B2 (en) * 2004-12-29 2014-04-15 Naturon, Inc. Xanthurenic acid derivative pharmaceutical compositions and methods related thereto
EP1845778A2 (de) * 2005-01-10 2007-10-24 University Of Virginia Patent Foundation Synthese von p90rsk-hemmern
US7691364B2 (en) * 2005-01-28 2010-04-06 Bezwada Biomedical, Llc Functionalized drugs and polymers derived therefrom
DK2444085T3 (en) 2005-05-13 2015-04-27 Univ California Diarylhydantoinforbindelser as androgenreceptorantagonister for treating cancer
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
EP2365000A3 (de) 2005-05-18 2013-01-16 Ablynx N.V. Verbesserte Nanokörper-TM gegen Tumornekrosefaktor Alpha
PL3415535T3 (pl) 2005-05-20 2021-06-14 Ablynx N.V. Ulepszone Nanociała TM do leczenia zaburzeń, w których pośredniczy agregacja
US20070025910A1 (en) 2005-07-29 2007-02-01 Norenberg Jeffrey P Anticancer therapy
JP4989648B2 (ja) * 2005-08-03 2012-08-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗癌剤として有用なイルジン類似体
JP2009504803A (ja) 2005-08-22 2009-02-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Tlrアゴニスト
CA2618970C (en) 2005-08-29 2015-03-31 University Of Virginia Patent Foundation Lisofylline analogs and methods for use
US8871764B2 (en) 2005-08-29 2014-10-28 University Of Virginia Patent Foundation Lisofylline analogs and methods for use
WO2007053794A2 (en) 2005-10-21 2007-05-10 Bezwada Biomedical Llc Functionalized phenolic compounds and absorbable therefrom
WO2007056113A2 (en) * 2005-11-02 2007-05-18 Cylene Pharmaceuticals, Inc. Methods for targeting quadruplex sequences
CN101374856A (zh) * 2005-11-29 2009-02-25 斯克里普斯研究学院 抑制肿瘤细胞浸润、转移和血管生成
US8007526B2 (en) 2005-12-01 2011-08-30 Bezwada Biomedical, Llc Difunctionalized aromatic compounds and polymers therefrom
WO2007078615A2 (en) * 2005-12-15 2007-07-12 Cavit Sciences, Inc Methods and compositions for treatment of cancer
WO2007073226A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda Method for treating a mammal by administration of a compound having the ability to release co
US20070244057A1 (en) * 2006-01-20 2007-10-18 Henry Paulson Suppressing polyglutamine aggregation and toxicity
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
US7615649B2 (en) * 2006-01-26 2009-11-10 Iowa State University Research Foundation, Inc, Synthesis of polycyclic procyanidins
US8178509B2 (en) * 2006-02-10 2012-05-15 University Of Virginia Patent Foundation Method to treat sickle cell disease
US20080009545A1 (en) * 2006-02-21 2008-01-10 The Ohio State University Research Foundation Anticancer agents
WO2007098281A2 (en) 2006-02-27 2007-08-30 Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
AU2007221020B9 (en) 2006-02-28 2013-04-04 Dart Neuroscience (Cayman) Ltd. Therapeutic compounds
CN101431996A (zh) * 2006-03-22 2009-05-13 加利福尼亚大学董事会 蛋白质异戊二烯基转移酶的抑制剂
DK2656841T3 (en) 2006-03-27 2016-12-05 Univ California Androgen receptor MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND androgen receptor-ASSOCIATED DISEASES
RU2449993C2 (ru) 2006-03-29 2012-05-10 Те Риджентс Оф Те Юниверсити Оф Калифорния Диарилтиогидантоиновые соединения
US8093235B2 (en) 2006-04-25 2012-01-10 Rutgers, The State University Of New Jersey Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA
US8426568B2 (en) * 2006-05-22 2013-04-23 University Of Virginia Patent Foundation Rhamnose substituents of SL0101 and therapeutic uses thereof
WO2007142755A2 (en) 2006-05-31 2007-12-13 The Regents Of The University Of California Purine analogs
ES2414205T3 (es) * 2006-06-02 2013-07-18 The Ohio State University Research Foundation Agentes terapéuticos para el tratamiento de linfoma de células del manto
US20110112086A1 (en) * 2006-06-08 2011-05-12 Cylene Pharmaceuticals, Inc. Pyridinone analogs
WO2007146831A2 (en) * 2006-06-08 2007-12-21 Cylene Pharmaceuticals, Inc. Quinolone analogs derivatized with sulfonic acid, sulfonate or sulfonamide
CN101466382A (zh) 2006-06-16 2009-06-24 PGx健康有限责任公司 取代的8-[6-氨基-3-吡啶基]黄嘌呤
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
WO2008034019A2 (en) 2006-09-13 2008-03-20 Polymerix Corporation Active agents and their oligomers and polymers
WO2008036244A1 (en) * 2006-09-18 2008-03-27 The Burham Institute For Medical Research Use of cyclosporin a to sensitize resistant cancer cells to death receptor ligands
US8022246B2 (en) * 2006-10-10 2011-09-20 The Burnham Institute For Medical Research Neuroprotective compositions and methods
US8034829B2 (en) 2006-11-17 2011-10-11 Rexahn Pharmaceuticals, Inc. 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof
JP2010511034A (ja) * 2006-11-29 2010-04-08 ファイザー・プロダクツ・インク 第Xa因子阻害剤としての(R)−5−メチル−4,5−ジヒドロ−ピラゾール−1,5−ジカルボン酸1−[(4−クロロ−フェニル)−アミド]5−{[2−フルオロ−4−(2−オキソ−2H−ピリジン−1−イル)−フェニル]−アミド}
EP2557090A3 (de) 2006-12-19 2013-05-29 Ablynx N.V. Gegen GPCRs gerichtete Aminosäuresequenzen und Polypeptide damit zur Behandlung von Krankheiten und Störungen im Zusammenhang mit GPCR
WO2008074840A2 (en) 2006-12-19 2008-06-26 Ablynx N.V. Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders
JP2010518108A (ja) 2007-02-06 2010-05-27 ユニバーシティ オブ ルーイビル リサーチ ファウンデーション,インコーポレーテッド 治療化合物
CN101790380B (zh) 2007-02-07 2013-07-10 加利福尼亚大学董事会 合成tlr激动剂的缀合物及其应用
WO2008103818A1 (en) * 2007-02-21 2008-08-28 University Of Louisville Research Foundation Therapeutic cotinine compositions
CA2679301C (en) 2007-02-28 2015-08-11 University Of Virginia Patent Foundation Lisofylline analogs and methods for use in protecting pancreatic .beta.-cells, treating type 1 diabetes, and treating inflammatory and autoimmune diseases
WO2008138001A2 (en) 2007-05-08 2008-11-13 University Of Louisville Research Foundation Synthetic peptides and peptide mimetics
BRPI0815563A2 (pt) 2007-07-12 2015-02-18 Univ South Florida Inibidores de akt/pkb com atividade antitumoral
JP2010535204A (ja) 2007-08-02 2010-11-18 ラトガーズ, ザ ステイト ユニバーシティ オブ ニュー ジャージー 治療用化合物
WO2009025797A1 (en) * 2007-08-16 2009-02-26 Burnham Institute For Medical Research Compositions and methods for treating symptoms of aging
WO2009029632A1 (en) 2007-08-27 2009-03-05 Helicon Therapeutics, Inc. Therapeutic isoxazole compounds
US8217134B2 (en) 2007-08-30 2012-07-10 Bezwada Biomedical, Llc Controlled release of biologically active compounds
US8048980B2 (en) 2007-09-17 2011-11-01 Bezwada Biomedical, Llc Hydrolysable linkers and cross-linkers for absorbable polymers
WO2009046383A1 (en) 2007-10-05 2009-04-09 Cylene Pharmaceuticals, Inc. Quinolone analogs and methods related thereto
CN101896068A (zh) * 2007-10-19 2010-11-24 伯恩哈姆医学研究协会 抗凋亡蛋白的萘基抑制剂
WO2009055677A1 (en) * 2007-10-24 2009-04-30 University Of South Florida Antibacterial s-heterosubstituted disulfides
CA2966280A1 (en) 2007-10-26 2009-04-30 The Regents Of The University Of California Diarylhydantoin compounds
US7951832B2 (en) * 2007-10-31 2011-05-31 Burnham Institute For Medical Research Pyrazole derivatives as kinase inhibitors
US9526737B2 (en) 2007-12-03 2016-12-27 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
WO2009099650A2 (en) * 2008-02-07 2009-08-13 Carson Dennis A Treatment of bladder diseases with a tlr7 activator
US8142764B2 (en) 2008-02-27 2012-03-27 University Of Louisville Research Foundation Synthetic biofilm-inhibiting peptides
WO2009114539A2 (en) * 2008-03-10 2009-09-17 University Of Louisville Research Foundation Neuroprotective integrin-binding peptide and angiopoietin-1 treatments
WO2009114921A1 (en) * 2008-03-17 2009-09-24 Dmitrienko Gary I INHIBITORS OF CLASS B AND CLASS D β-LACTAMASES
WO2009146112A1 (en) * 2008-04-02 2009-12-03 University Of Virginia Patent Foundation Compositions and methods for inhibiting sphingosine kinase
EP2947097A1 (de) 2008-04-07 2015-11-25 Ablynx N.V. Gegen Notch-Signalwege gerichtete Aminosäuresequenzen und Verwendungen davon
US9212226B2 (en) 2008-05-16 2015-12-15 Ablynx N.V. Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same
US9872867B2 (en) * 2008-06-06 2018-01-23 Tanya Kuritz Methods and compositions for modulation of innate immunity
EP2299809B1 (de) 2008-06-17 2018-10-17 Ben Gurion University Of The Negev R&D Authority Substituierte cyclohexyliden-ethyliden-octahydroinden-verbindungen
WO2010005534A2 (en) * 2008-06-30 2010-01-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Proteasome inhibitors for selectively inducing apoptosis in cancer cells
US7947717B2 (en) * 2008-07-18 2011-05-24 Burnham Institute For Medical Research Inhibitors of lethal factor protease
US9125821B2 (en) 2008-07-28 2015-09-08 The Regents Of The University Of California Nanodrug targeting protein geranylgeranylation
US20110178138A1 (en) 2008-07-28 2011-07-21 The Regents Of The University Of California Inhibitors of protein prenyltransferases
US9132168B2 (en) 2008-08-05 2015-09-15 University Of South Florida Methods of treating cognitive impairment
WO2010017224A2 (en) * 2008-08-05 2010-02-11 University Of South Florida Methods of treating cognitive impairment
JP2011530539A (ja) * 2008-08-08 2011-12-22 ユニバーシティ オブ フロリダ リサーチ ファウンデーション,インク. 腫瘍形成を抑制する脂質化合物
US9801865B2 (en) * 2008-09-24 2017-10-31 The United States Of America As Represented By The Department Of Veteran Affairs Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation
US8124654B2 (en) * 2008-11-11 2012-02-28 Immune Modulation, Inc. Derivatives of hypoestoxide and related compounds
TW201038578A (en) 2009-01-30 2010-11-01 Univ Rutgers Methods to treat cancer
WO2010088924A1 (en) 2009-02-06 2010-08-12 Telormedix Sa Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
BRPI1008383A2 (pt) 2009-02-11 2016-02-23 Univ California composto, composição farmacêutica, método para prevenir, inibir ou tratar uma condição, e, uso de um composto
WO2010102219A1 (en) 2009-03-06 2010-09-10 Rutgers, The State University Of New Jersey Methylenedioxybenzo [i] phenanthridine derivatives used to treat cancer
WO2010108190A1 (en) 2009-03-20 2010-09-23 University Of Iowa Research Foundation Prenylated bisphosphonates as anti-tuberculosis agents
EP2417163B1 (de) 2009-04-10 2019-02-27 Ablynx N.V. Verbesserte, gegen il-6r gerichtete aminosauresequenzen und polypeptide, die diese enthalten, zur behandlung von erkrankungen und storungen, die mit il-6r in zusammenhang stehen
US8487131B2 (en) 2009-04-15 2013-07-16 Sanford-Burnham Medical Research Institute Optically pure apogossypol derivative as pan-active inhibitor of anti-apoptotic B-cell lymphoma/leukemia-2 (BCL-2)
EA201101326A1 (ru) 2009-04-15 2012-05-30 Сэнфорд-Бёрнхэм Медикал Рисёч Инститьют Ингибиторы антиапоптотических белков на основе нафталина
US20120108823A1 (en) 2009-04-22 2012-05-03 The Ohio State University Research Foundation Anti-francisella agents
WO2010132504A1 (en) 2009-05-11 2010-11-18 University Of Tennessee Research Foundation Anti-inflammatory quinic acid derivatives for radioprotection/radiomitigation
WO2010132684A2 (en) 2009-05-13 2010-11-18 University Of Virginia Patent Foundation Inhibitors of inv(16) leukemia
KR20120107065A (ko) 2009-06-30 2012-09-28 포레스트 래보러토리즈 홀딩스 리미티드 A2ar 효현제용 알콕시 카르보닐 아미노 알키닐 아데노신 화합물 및 그 유도체
WO2011005871A1 (en) 2009-07-07 2011-01-13 Pgxhealth, Llc Substituted 8-[6-carbonylamine-3-pyridyl]xanthines as adenosine a2b antagonists
WO2011004166A1 (en) 2009-07-09 2011-01-13 Cbt Development Limited Combined preparation for use as a medicament
AU2010278730A1 (en) 2009-07-31 2012-03-01 Biocryst Pharmaceuticals, Inc. Pyrrolo [1, 2-b] pyridazine derivatives as janus kinase inhibitors
US9040673B2 (en) 2009-08-14 2015-05-26 University Of Virginia Patent Foundation Synthesis and identification of novel RSK-specific inhibitors
TW201111385A (en) 2009-08-27 2011-04-01 Biocryst Pharm Inc Heterocyclic compounds as janus kinase inhibitors
EP2473041B1 (de) 2009-09-04 2018-03-07 Merck Sharp & Dohme Corp. Modulatoren von zellzyklus-kontrollpunkten und ihre verwendung in kombination mit kontrollpunkt-kinasehemmern
US8642088B2 (en) 2009-09-04 2014-02-04 Wisconsin Alumni Research Foundation Tannin-chitosan composites
JP2013507380A (ja) * 2009-10-08 2013-03-04 サンフォード−バーンハム メディカル リサーチ インスティテュート 抗癌剤としてのアポゴシポロン誘導体
CA2780145A1 (en) 2009-11-05 2011-05-12 Rutgers, The State University Of New Jersey Therapeutic compounds
KR20120092175A (ko) 2009-12-04 2012-08-20 죤 이. 그랜트 카테콜-0-메틸-트랜스퍼라제 저해제를 사용한 충동 제어 장애의 치료
EP2516396A1 (de) 2009-12-23 2012-10-31 Wayne State University Therapeutische verbindungen
EP2516444A2 (de) 2009-12-23 2012-10-31 Biocryst Pharmaceuticals, Inc. Heterocyclische verbindungen als januskinasehemmer
WO2011103202A2 (en) 2010-02-16 2011-08-25 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
CA2828114A1 (en) 2010-02-26 2011-09-01 Gary Igor DMITRIENKO Cephalosporin derivatives useful as .beta.-lactamase inhibitors and compositions and methods of use thereof
US8697105B2 (en) 2010-03-29 2014-04-15 Surmodics, Inc. Injectable drug delivery formulation
WO2011123856A1 (en) 2010-04-02 2011-10-06 Tsrl, Inc. Neuraminidase inhibitors
WO2011127344A2 (en) 2010-04-08 2011-10-13 University Of Virginia Patent Foundation Method to detect and treat infectious or inflammatory diarrhea
US9221808B2 (en) 2010-04-16 2015-12-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use
WO2011133696A2 (en) 2010-04-20 2011-10-27 Regents Of The University Of Minnesota Methods of suppressing atherosclerosis
WO2011150356A1 (en) 2010-05-28 2011-12-01 Biocryst Pharmaceuticals, Inc. Heterocyclic compounds as janus kinase inhibitors
WO2011156626A1 (en) 2010-06-09 2011-12-15 Rutgers, The State University Of New Jersey Antimicrobial agents
US9102617B2 (en) 2010-06-25 2015-08-11 Rutgers, The State University Of New Jersey Antimicrobial agents
US8741317B2 (en) 2010-08-19 2014-06-03 Rutgers, The State University Of New Jersey Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery
WO2012027494A1 (en) 2010-08-24 2012-03-01 Regents Of The University Of Minnesota Bispecific targeting reagents
WO2012038058A1 (en) 2010-09-21 2012-03-29 Telormedix Sa Treatment of conditions by toll-like receptor modulators
MX2013004679A (es) 2010-10-25 2014-02-20 Univ Minnesota Composicion terapeutica para el tratamiento de glioblastoma.
WO2012058665A1 (en) 2010-10-29 2012-05-03 University Of Connecticut Compositions and methods for modulation and detection of immune and inflammatory responses
EP2635274B1 (de) 2010-11-01 2017-12-06 The Ohio State University Research Foundation Celecoxibderivate gegen staphylokokken
WO2012065051A1 (en) 2010-11-12 2012-05-18 Enzon Pharmaceuticals, Inc. Compositions and methods for treating androgen receptor dependent disorders including cancers
WO2012074960A2 (en) 2010-11-29 2012-06-07 The Ohio State University Research Foundation Fty720-derived anticancer agents
WO2012087889A2 (en) 2010-12-20 2012-06-28 The Ohio State University Research Foundation Dna methylation inhibitors
US8933119B2 (en) 2011-01-03 2015-01-13 The William M. Yarbrough Foundation Method for treating phytophotodermatitis
US10647668B2 (en) 2011-01-03 2020-05-12 The William M. Yarbrough Foundation Isothiocyanate functional surfactant and associated method of use
US9962361B2 (en) 2011-01-03 2018-05-08 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US11407713B2 (en) 2011-01-03 2022-08-09 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US10640464B2 (en) 2011-01-03 2020-05-05 The William M. Yarbrough Foundation Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases
US11279674B2 (en) 2011-01-03 2022-03-22 The William M. Yarbrough Foundation Isothiocyanate functional surfactant and associated method of use
US10308599B2 (en) 2011-01-03 2019-06-04 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US10273205B2 (en) 2011-01-03 2019-04-30 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms
US8865765B2 (en) 2011-01-12 2014-10-21 The William M. Yarbrough Foundation Method for treating eczema
ME02556B (de) 2011-02-07 2017-02-20 Biogen Ma Inc S1p-modulierende mittel
US9532969B2 (en) 2011-02-08 2017-01-03 The William M. Yarbrough Foundation Method for treating psoriasis
CA2865487A1 (en) 2011-03-07 2012-09-13 Paula J. Bates Predictive marker of dnmt1 inhibitor therapeutic efficacy and methods of using the marker
WO2012135697A2 (en) 2011-03-30 2012-10-04 H. Lee Moffitt Cancer Center & Research Institute Inc. Novel rho kinase inhibitors and methods of use
MX356426B (es) 2011-04-04 2018-05-29 Univ Iowa Res Found Metodos para mejorar inmunogenicidad de vacuna.
US20140030341A1 (en) 2011-04-06 2014-01-30 Rutgers, The State University Of New Jersey Polymers and methods for the treatment of pain
JP5978291B2 (ja) 2011-04-19 2016-08-24 アルファーマ インコーポレイテッドAlfama,Inc. 一酸化炭素放出分子およびその使用
WO2012145678A1 (en) 2011-04-20 2012-10-26 Regents Of The University Of Minnesota Anti-cancer and anti-inflammatory parthenolide compounds
WO2012177770A1 (en) 2011-06-20 2012-12-27 Rutgers, The State University Of New Jersey Bipartite inhibitors of bacterial rna polymerase
US9133230B2 (en) 2011-06-21 2015-09-15 The United States Of America As Represented By The Department Of Veterans Affairs Hydrazone derivatives having potent antitumor activity toward multi-drug resistant tumor cells
US9394338B2 (en) 2011-07-08 2016-07-19 Regents Of The University Of Minnesota Glutathione analogs and uses thereof
ES2628634T3 (es) 2011-07-21 2017-08-03 Alfama, Inc. Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas
WO2013016206A1 (en) 2011-07-22 2013-01-31 University Of Louisville Research Foundation, Inc. Anti-biofilm compounds
EA028452B1 (ru) 2011-07-29 2017-11-30 Медивейшн Простейт Терапьютикс, Инк. Лечение рака молочной железы
US20150017091A1 (en) 2011-08-18 2015-01-15 Cornell University Detection and treatment of metastatic disease
WO2013028866A1 (en) 2011-08-24 2013-02-28 Regents Of The University Of Minnesota Therapeutic compounds and methods
CA2846860A1 (en) 2011-08-30 2013-03-07 Wayne State University Therapeutic compounds and methods
WO2013033345A1 (en) 2011-08-30 2013-03-07 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
WO2013036931A1 (en) 2011-09-08 2013-03-14 Western University Of Health Sciences Targeted liposomes in cancer therapy
EP2910549A1 (de) 2011-09-15 2015-08-26 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University 1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalenderivate als rxr-modulatoren zur behandlung von alzheimer-krankheit und krebs
TR201818978T4 (tr) * 2011-11-04 2019-01-21 Enceladus Pharmaceuticals B V İnsanlardaki İnflamatuvar Rahatsızlıkların Tedavisine Yönelik Lipozomal Kortikosteroidler
US9828326B2 (en) * 2011-12-27 2017-11-28 Northeast Ohio Medical University Amooranin compounds and analogs thereof and related methods of use
US9517994B2 (en) 2012-01-05 2016-12-13 Rutgers, The State University Of New Jersey Antibacterial agents: phloroglucinol derivatives
WO2013106572A1 (en) 2012-01-11 2013-07-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Bispecific antibody fragments for neurological disease proteins and methods of use
US9822108B2 (en) 2012-01-13 2017-11-21 Rutgers, The State University Of New Jersey Antimicrobial agents
EP2804606B1 (de) 2012-01-19 2017-06-28 Hybrid Medical, LLC Topische therapeutische formulierungen
WO2013109972A2 (en) 2012-01-20 2013-07-25 Regents Of The University Of Minnesota Therapeutic compounds
US9488664B2 (en) 2012-01-25 2016-11-08 Sbi Pharmaceuticals Co., Ltd. Diagnostic agent for tumor
US20130195752A1 (en) 2012-02-01 2013-08-01 Regents Of The University Of Minnesota Functionalized nanoparticles and methods of use thereof
WO2013113102A1 (en) 2012-02-01 2013-08-08 The Governors Of The University Of Alberta USE OF PDGFR-α AS DIAGNOSTIC MARKER FOR PAPILLARY THYROID CANCER
WO2013119564A1 (en) 2012-02-06 2013-08-15 Rutgers, The State University Of New Jersey Antibacterial agents: combination of a rifamycin and a switch region inhibitor
US9688668B2 (en) 2012-02-08 2017-06-27 University Of Virginia Patent Foundation Long chain base sphingosine kinase inhibitors
US9592229B2 (en) 2012-03-02 2017-03-14 The Board Of Trustees Of The University Of Illinois Potent anticancer activity via dual compound activation
DK2822546T3 (en) 2012-03-06 2017-10-30 The Board Of Trustees Of The Univ Of Illionis PROCASPACE COMBINATION THERAPY FOR CANCER TREATMENT
US9475783B2 (en) 2012-03-21 2016-10-25 Rutgers, The State University Of New Jersey Antimicrobial agents
WO2013142812A1 (en) 2012-03-22 2013-09-26 Rutgers, The State University Of New Jersey Antibacterial agents: sidechain-fluorinated myxopyronin derivatives
CN104583203B (zh) 2012-03-26 2017-06-13 衣阿华大学研究基金会 Schweinfurthin类似物
US9272016B2 (en) 2012-04-20 2016-03-01 University Of Iowa Research Foundation Methods to enhance RNAi oligonucleotide delivery to respiratory epithelial cells
JP6262723B2 (ja) 2012-05-07 2018-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California オキシステロールアナログoxy133は、骨発生及びヘッジホッグシグナル伝達を誘導し、脂肪生成を阻害する
EP2852390A1 (de) 2012-05-21 2015-04-01 Chemi Nutra Inc. Zusammensetzungen und verfahren zur erhöhung der festigkeit und muskelmasse
WO2013177458A1 (en) 2012-05-23 2013-11-28 Chemi Nutra Compositions for increasing strength, muscle mass, and lean body mass
EP2854834A4 (de) 2012-05-30 2016-05-18 Biostrategies LC Pflanzenlektine als träger entsprechender wirkstoffe in tierischen und menschlichen zellen
US9434681B2 (en) 2012-06-15 2016-09-06 Rutgers, The State University Of New Jersey Macromolecules for treating atherosclerosis
JP6240180B2 (ja) 2012-06-18 2017-11-29 ダート・ニューロサイエンス・(ケイマン)・リミテッド 置換チオフェン−およびフラン−縮合アゾロピリミジン−5−(6h)−オン化合物
EP2861570B1 (de) 2012-06-19 2018-07-18 Rutgers, The State University of New Jersey Antibakterielle wirkstoffe: arylmyxopyroninderivate
EP2863910B1 (de) 2012-06-20 2020-03-11 University Of Virginia Patent Foundation Zusammensetzungen und verfahren zur regulierung einer glucosehomöostase und einer insulinwirkung
JP6226974B2 (ja) 2012-07-05 2017-11-08 ユニバーシティー オブ アイオワ リサーチ ファウンデーション 治療用ビスホスホネート
EP2872525B1 (de) 2012-07-10 2019-03-06 XPD Holdings LLC Stabilisierte multifunktionale antioxidative verbindungen und verfahren zur verwendung
BR112015001201B1 (pt) 2012-07-18 2022-02-22 University Of Notre Dame Du Lac Compostos anti-infecciosos 5,5-heteroaromáticos e composição
WO2014018671A1 (en) 2012-07-24 2014-01-30 Regents Of The University Of Minnesota Therapeutic compounds for the treatment of cancer
US10441561B2 (en) 2012-07-26 2019-10-15 The William M. Yanbrough Foundation Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer
US9949943B2 (en) 2012-07-26 2018-04-24 The William M. Yarbrough Foundation Method for treating neurodegenerative diseases
US10434082B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms
US10434081B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Inhibitors of macrophage migration inhibitory factor
WO2014018874A1 (en) 2012-07-26 2014-01-30 The William M. Yarbrough Foundation Method for treating skin cancer
US10080734B2 (en) 2012-07-26 2018-09-25 The William M. Yarbrough Foundation Method for treating autism and other neurodevelopmental disorders
US10335387B2 (en) 2012-07-26 2019-07-02 The William M. Yarbrough Foundation Method for treating infectious diseases with isothiocyanate functional compounds
US9839621B2 (en) 2012-07-26 2017-12-12 The William M. Yarbrough Foundation Method for treating bladder cancer
MX363388B (es) 2012-07-27 2019-03-20 Biogen Ma Inc Agentes moduladores de autotaxina.
JP6545618B2 (ja) 2012-08-01 2019-07-17 ルイス アンド クラーク ファーマスーティカルズ,インコーポレイテッドLewis and Clark Pharmaceuticals,Inc. A2aアゴニストとしてのn−アルキル2−(二置換)アルキニルアデノシン−5’−ウロンアミド
RU2652989C2 (ru) 2012-08-03 2018-05-04 Зэ Борд оф Трастиз оф зэ Юниверсити оф Иллинойс Соединения и композиции, активирующие ферменты
EP2879674B1 (de) 2012-08-06 2017-11-22 Biogen MA Inc. Verbindungen als s1p-modulierende mittel und/oder atx-modulierende mittel
US9499485B2 (en) 2012-08-06 2016-11-22 Biogen Ma Inc. Compounds that are S1P modulating agents and/or ATX modulating agents
WO2014028025A1 (en) 2012-08-16 2014-02-20 University Of Southern California Compositions and methods for treating myotonic dystrophy type 1
US10208043B2 (en) 2012-08-22 2019-02-19 Cornell University Methods for inhibiting fascin
US9737493B2 (en) 2012-09-07 2017-08-22 University Of Louisville Research Foundation, Inc. Compositions and methods for modulating DNMT1 inhibitor activity
US9573938B2 (en) 2012-09-11 2017-02-21 Rutgers, The State University Of New Jersey Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones
WO2014041546A1 (en) 2012-09-13 2014-03-20 Ben-Gurion University Of The Negev Research And Development Authority Diagnostic agents with enhanced sensitivity/specificity
WO2014043510A1 (en) 2012-09-13 2014-03-20 Chang Gung Memorial Hospital A novel pharmaceutical composition and uses thereof
KR20220025231A (ko) 2012-09-26 2022-03-03 아라곤 파마슈티컬스, 인코포레이티드 비전이성 거세 저항성 전립선암 치료용 항안드로겐
EP2906260B1 (de) 2012-10-09 2019-06-26 Case Western Reserve University Stabförmige pflanzenvirusnanopartikel als kontrastmittelplattformen
AU2013329171A1 (en) 2012-10-10 2015-04-30 Arizona Board Of Regents, On Behalf Of Arizona State University Multifunctional radical quenchers
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
WO2014066840A1 (en) 2012-10-26 2014-05-01 Regents Of The University Of Minnesota Aurora kinase inhibitors
WO2014070774A1 (en) 2012-10-29 2014-05-08 Southern Methodist University Methods of generating beta-lactamase resistant carbapenem compounds
WO2014074932A1 (en) 2012-11-08 2014-05-15 Rutgers, The State University Of New Jersey Antimicrobial agents
US9701638B2 (en) 2012-11-09 2017-07-11 Rutgers, The State University Of New Jersey Therapeutic hydroxyquinolones
CA2890905A1 (en) 2012-11-16 2014-05-22 Biocryst Pharmaceuticals, Inc. Antiviral azasugar-containing nucleosides
WO2014078857A1 (en) 2012-11-19 2014-05-22 Regents Of The University Of Minnesota Ergoline derivatives as dopamine receptor modulators
ES2749467T3 (es) 2012-11-20 2020-03-20 Biogen Ma Inc Agentes moduladores de S1p y/o ATX
WO2014081752A1 (en) 2012-11-20 2014-05-30 Biogen Idec Ma Inc. S1p and/or atx modulating agents
US9522131B2 (en) 2013-01-11 2016-12-20 Wisconsin Alumni Research Foundation Tannin-containing gastrointestinal formulations and methods of use
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
JP6434425B2 (ja) 2013-01-29 2018-12-05 バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. S1p調節剤
WO2014124317A1 (en) 2013-02-08 2014-08-14 Regents Of The University Of Minnesota Analgesic conjugates
KR20150119188A (ko) 2013-02-15 2015-10-23 리젠츠 오브 더 유니버시티 오브 미네소타 입자 기능화
EP2964618B1 (de) 2013-03-05 2019-09-04 University Of Notre Dame Du Lac Chinazolinon-antibiotika
JP6346658B2 (ja) 2013-03-14 2018-06-20 ダート・ニューロサイエンス・(ケイマン)・リミテッド Mao阻害剤としての置換ナフチリジン及びキノリン化合物
RU2668073C2 (ru) 2013-03-14 2018-09-26 Дарт Нейросайенс (Кайман) Лтд. Замещенные пиридиновые и пиразиновые соединения в качестве ингибиторов pde4
US9617282B2 (en) 2013-03-15 2017-04-11 Biogen Ma Inc. Macrocyclic compounds as IRAK4 inhibitors for the treatment of inflammatory diseases
BR112015023184A2 (pt) 2013-03-15 2017-11-21 Constellation Pharmaceuticals Inc método para o tratamento de uma doença, inibidor e seu uso, composição, método de identificação de um composto e método para inibir a produção de il-4, il-5 e il-13
CN110483413B (zh) 2013-03-15 2023-02-28 百缮药业(苏州)有限公司 用于制备碳环糖衍生物的方法
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
TW201446768A (zh) 2013-03-15 2014-12-16 Biogen Idec Inc S1p及/或atx調節劑
AU2014259672A1 (en) 2013-05-02 2015-12-03 The Regents Of The University Of California Bone-selective osteogenic oxysterol-bone targeting agents
CN105555363B (zh) 2013-05-06 2019-03-12 长庚医疗财团法人高雄长庚纪念医院 医药组成物及其用途
WO2014194055A1 (en) 2013-05-29 2014-12-04 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
US9452217B2 (en) 2013-06-22 2016-09-27 Nitor Therapeutics Methods for potentiating immune response for the treatment of infectious diseases and cancer
US10682415B2 (en) 2013-07-22 2020-06-16 Wisconsin Alumni Research Foundation Thermogel formulation for combination drug delivery
WO2015017715A1 (en) 2013-08-01 2015-02-05 Regents Of The University Of Minnesota Drug delivery method
CN104341504B (zh) 2013-08-06 2017-10-24 百奥泰生物科技(广州)有限公司 双特异性抗体
WO2015021149A1 (en) 2013-08-06 2015-02-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibitors of ack1/tnk2 tyrosine kinase
WO2015038966A1 (en) 2013-09-12 2015-03-19 Regents Of The University Of Minnesota Semi-solid delivery systems
US9878045B2 (en) 2013-10-15 2018-01-30 Regents Of The University Of Minnesota Triorthogonal reagents for dual protein conjugation
EP3068416A4 (de) 2013-11-11 2017-08-09 Kuality Herbceutics LLC Therapeutische verbindungen aus kava und verfahren zur verwendung davon
US9387199B2 (en) 2013-11-12 2016-07-12 University Of Virginia Patent Foundation Compositions and methods for treating clostridium infection and preventing recurrence of infection
US9339482B2 (en) 2013-11-22 2016-05-17 Regents Of The University Of Minnesota Methods to treat dysregulated blood glucose disorders
US9315523B2 (en) 2013-12-06 2016-04-19 Rutgers, The State University Of New Jersey Cyclic dinucleosides
US10328040B2 (en) 2014-01-17 2019-06-25 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic methods
US9919998B2 (en) 2014-02-06 2018-03-20 Rutgers, The State University Of New Jersey Antibacterial agents: Nα-aroyl-N-aryl-phenylalaninamides
US20150231077A1 (en) 2014-02-17 2015-08-20 The Cleveland Clinic Foundation Amine passivated nanoparticles for cancer treatment and imaging
DK3107902T3 (da) 2014-02-20 2021-05-03 Cornell Univ Cornell Center For Technology Enterprise & Commercialization Cctec Forbindelser og fremgangsmåder til at hæmme fascin
US10189874B2 (en) 2014-02-26 2019-01-29 Arizona Board Of Regents On Behalf Of Arizona State University DNA gridiron compositions and methods
WO2015130973A1 (en) 2014-02-26 2015-09-03 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10272055B2 (en) 2014-03-06 2019-04-30 Regents Of The University Of Minnesota Therapeutic compounds and methods
BR112016020199A8 (pt) 2014-03-07 2021-07-20 Biocryst Pharm Inc composto inibidor de calicreína plasmática de humano, composição farmacêutica compreendendo o referido composto, kit e seu uso
WO2015153560A1 (en) 2014-03-31 2015-10-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. Stabilized peptoid-peptide hybrids and uses thereof
WO2015166355A2 (en) 2014-04-18 2015-11-05 The Governors Of The University Of Alberta Targeted therapy to restore radioactive iodine transport in thyroid cancer
ES2759246T3 (es) 2014-04-23 2020-05-08 Dart Neuroscience Cayman Ltd Compuestos de[1,2,4]triazolo[1,5-a]pirimidinilo-7-il sustituidos como inhibidores de PDE2
EP3134406A1 (de) 2014-04-24 2017-03-01 Dart Neuroscience (Cayman) Ltd Substituierte 2,4,5,6-tetrahydropyrrolo [ 3,4-c ] pyrazol-und 4,5,6,7-tetrahydro-2 h-pyrazolo [ 4,3-c ] pyridinverbindungen als glyt1-inhibitoren
US9556113B2 (en) 2014-04-29 2017-01-31 The South Dakota Board Of Regents Combination uses of dichloroacetate and oxamate, and their prodrugs, for cancer treatment
US9987299B2 (en) 2014-05-05 2018-06-05 University Of Iowa Research Foundation Methods of improving RNAi in well-differentiated airway epithelia
WO2015188051A1 (en) 2014-06-06 2015-12-10 Biogen Ma Inc. Atx modulating agents
WO2015191742A1 (en) 2014-06-13 2015-12-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
WO2015195563A1 (en) 2014-06-16 2015-12-23 Rutgers, The State University Of New Jersey Antibacterial agents
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
US9737598B2 (en) 2014-06-30 2017-08-22 Regents Of The University Of Minnesota CD200 inhibitors and methods of use thereof
US20170191041A1 (en) 2014-07-11 2017-07-06 Biostrategies LC Materials and methods for treating disorders associated with sulfatase enzymes
US10246456B2 (en) 2014-07-18 2019-04-02 Biogen Ma Inc. IRAK4 inhibiting agents
EP3232199B1 (de) * 2014-08-19 2022-05-04 National University Corporation Okayama University Verfahren zur erhöhung der immunzellenfunktion und verfahren zur beurteilung der multifunktionalität von immunzellen
WO2016027262A1 (en) 2014-08-19 2016-02-25 Miller Marvin J Antibacterial sideromycins
WO2016037171A1 (en) 2014-09-05 2016-03-10 The Cleveland Clinic Foundation Flavonoid il-17a inhibitors
US9630905B2 (en) 2014-09-08 2017-04-25 Rutgers, The State University Of New Jersey Amphiphilic macromolecules and methods of use thereof
EP3191086B1 (de) 2014-09-11 2021-05-05 University of Iowa Research Foundation Thymol und carvacol zur verwendung in der medizin
US10328114B2 (en) 2014-10-28 2019-06-25 University Of Iowa Research Foundation Lung injury repair compositions and methods
US10239882B2 (en) 2014-11-05 2019-03-26 Dart Neuroscience (Cayman) Ltd. Substituted 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine compounds as PDE2 inhibitors
US10040759B2 (en) 2014-11-05 2018-08-07 Dart Neuroscience (Cayman) Ltd. Substituted azetidinyl compounds as GlyT1 inhibitors
KR20170081261A (ko) * 2014-11-10 2017-07-11 델 마 파마슈티컬스 인코포레이티드 방사선과 함께 폐의 비-소세포 암종 및 다형성 교아종을 치료하기 위한 디안하이드로갈락티톨
US10920195B2 (en) 2014-11-13 2021-02-16 University Of Iowa Research Foundation Methods to generate epithelial cells
EP3229810B1 (de) 2014-11-17 2020-07-22 Cellectar Biosciences, Inc. Phospholipidetheranaloga als auf krebs abzielende arzneimittelträger
US11426468B2 (en) 2014-12-19 2022-08-30 Ablynx N.V. Cysteine linked nanobody dimers
US20180000736A1 (en) 2015-01-08 2018-01-04 University Of Iowa Research Foundation Methods for the regeneration of articular cartilage in vivo
WO2016115516A1 (en) 2015-01-16 2016-07-21 University Of Iowa Research Foundation Methods to prevent or treat periodontitis or peri-implantitis
EP3258938B1 (de) 2015-02-17 2020-12-02 Arizona Board of Regents on behalf of Arizona State University Phenothiazinanaloge als mitochondriales therapeutisches mittel
US10364227B2 (en) 2015-02-17 2019-07-30 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
WO2016140978A1 (en) 2015-03-03 2016-09-09 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
WO2016140979A1 (en) 2015-03-03 2016-09-09 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
JP2018507246A (ja) 2015-03-06 2018-03-15 ザ クリーヴランド クリニック ファウンデーションThe Cleveland Clinic Foundation ステロイド依存性疾患を治療するためのステロイド代謝の改変
US9926261B2 (en) 2015-03-10 2018-03-27 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
US9950993B2 (en) 2015-03-13 2018-04-24 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
WO2016164898A1 (en) 2015-04-10 2016-10-13 Rutgers, The State University Of New Jersey Kojic acid polymers
AU2016258123A1 (en) 2015-05-06 2018-01-04 H. Lee Moffitt Cancer Center And Research Institute, Inc. Radiotherapeutic and companion imaging agents to target MC1R
US10584108B2 (en) 2015-05-07 2020-03-10 Kuality Herbceutics Llc Therapeutic compounds and methods of use thereof
US20180125780A1 (en) 2015-05-15 2018-05-10 The Methodist Hospital System Implantable nanochannel delivery devices
EP3297655B1 (de) 2015-05-18 2020-04-15 Arizona Board of Regents on Behalf of the University of Arizona Verbesserte melanomkrebsprävention durch neuartige melanotropine
CN117257802A (zh) 2015-06-05 2023-12-22 伊利诺伊大学董事会 Pac-1联合疗法
TW201710503A (zh) 2015-06-12 2017-03-16 長庚醫療財團法人林口長庚紀念醫院 新穎多核苷酸、載體、醫藥組成物以及其用途
US11369569B2 (en) 2015-06-15 2022-06-28 University Of Virginia Patent Foundation Target-specific delivery of therapeutic agents
US10308663B2 (en) 2015-06-16 2019-06-04 University Of Virginia Patent Foundation Inhibitors of PTP4A3 for the treatment of cancer
US9399039B1 (en) 2015-06-30 2016-07-26 University Of South Florida Inhibitors of the FKBP51 protein from a high-throughput drug screen and methods of use
US10814006B2 (en) 2015-07-14 2020-10-27 University Of Iowa Research Foundation Fluorescent prodrugs
WO2017011826A1 (en) 2015-07-16 2017-01-19 Case Western Reserve University Plant virus particles for delivery of antimitotic agents
AU2016298175B2 (en) 2015-07-28 2022-01-06 University Of Iowa Research Foundation Compositions and methods of treating cancer
AU2016301212A1 (en) 2015-08-02 2018-03-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibitors of ACK1/TNK2 tyrosine kinase
WO2017027883A1 (en) 2015-08-13 2017-02-16 San Diego State University Research Foundation Atropisomerism for increased kinase inhibitor selectivity
DK3344614T5 (da) 2015-09-04 2021-08-30 Janssen Pharmaceutica Nv Terapeutiske forbindelser til smerte og syntese deraf
EP3355890B1 (de) 2015-10-01 2021-11-10 Biocryst Pharmaceuticals, Inc. Menschliche plasmakallikreinhemmer
WO2017066428A1 (en) 2015-10-13 2017-04-20 H. Lee Moffitt Cancer Center & Research Institute, Inc. Brd4-kinase inhibitors as cancer therapeutics
EP3365018A1 (de) 2015-10-20 2018-08-29 The Cleveland Clinic Foundation Stimulierung von 11beta-hsd2-expression zur verbesserung der hormontherapie einer steroidabhängigen erkrankung
JP6902185B2 (ja) 2015-11-03 2021-07-14 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Cd200阻害剤及びその使用方法
CN108601789A (zh) 2015-11-20 2018-09-28 生华生物科技股份有限公司 用于治疗癌症的四环喹诺酮类似物组合疗法
US9957282B2 (en) 2015-12-14 2018-05-01 Senhwa Biosciences, Inc. Crystalline forms of quinolone analogs and their salts
US9980951B2 (en) 2015-12-17 2018-05-29 University Of Iowa Research Foundation Image guided therapy for cancer
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
US11427561B2 (en) 2016-01-20 2022-08-30 Biogen Ma Inc. IRAK4 inhibiting agents
TW202222786A (zh) 2016-02-01 2022-06-16 美商百歐克斯製藥公司 苯并吡唑化合物及其類似物
WO2017156527A1 (en) 2016-03-11 2017-09-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Aurora kinase and janus kinase inhibitors for prevention of graft versus host disease
MX2018011216A (es) 2016-03-16 2019-08-29 H Lee Moffitt Cancer Ct & Res Moléculas pequeñas contra cereblon para mejorar la función efectora de los linfocitos t.
WO2017165558A1 (en) 2016-03-22 2017-09-28 Regents Of The University Of Minnesota Combination for treating pain
US10759740B2 (en) 2016-03-24 2020-09-01 Rutgers, The State University Of New Jersey Antibacterial agents
JP2019515025A (ja) 2016-04-04 2019-06-06 ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー トポイソメラーゼ毒
US10551384B2 (en) 2016-04-07 2020-02-04 Rutgers, The State University Of New Jersey MTOR kinase mutations and methods of use thereof
EP4230713A1 (de) 2016-04-18 2023-08-23 Gene Pool Technologies, Inc. Isolierung von pflanzenextrakten
AU2017260460A1 (en) 2016-05-04 2018-12-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. A delta-opioid receptor targeted agent for molecular imaging and immunotherapy of cancer
US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
KR102434879B1 (ko) 2016-05-26 2022-08-22 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 폐혈관 질환 치료용 조성물 및 방법
US10899793B2 (en) 2016-05-27 2021-01-26 Regents Of The University Of Minnesota Melanocortin ligands and methods of use thereof
US11351270B2 (en) 2016-06-07 2022-06-07 University Of Iowa Research Foundation Junctophilin-2 fragments and uses therefor
KR20190026771A (ko) 2016-06-20 2019-03-13 럿거스, 더 스테이트 유니버시티 오브 뉴 저지 치료 화합물
US11179484B2 (en) 2016-06-24 2021-11-23 University Of Iowa Research Foundation Compositions and methods of treating melanoma
ES2937307T3 (es) 2016-07-26 2023-03-27 Univ Southern California Inhibición selectiva del bromodominio del BDF1 fúngico
US20180037909A1 (en) 2016-08-04 2018-02-08 Chang Gung Memorial Hospital, Linkou Modified cancer cell lines and uses thereof
WO2018039077A1 (en) 2016-08-25 2018-03-01 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
KR102471059B1 (ko) 2016-08-31 2022-11-25 다트 뉴로사이언스, 엘엘씨 장애의 치료를 위한 하이드록시노르케타민 유도체
RU2019114964A (ru) 2016-10-17 2020-11-17 Дженентек, Инк. Терапевтические средства и способы их применения
US11124541B2 (en) 2016-10-18 2021-09-21 Regents Of The University Of Minnesota Chimeric melanocortin ligands and methods of use thereof
JP7128181B2 (ja) 2016-10-31 2022-08-30 バイオクリスト ファーマスーティカルズ,インコーポレイテッド カリクレイン阻害剤のプロドラッグ
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
CA3044814A1 (en) 2016-11-29 2018-06-07 Charles M. Brenner Use of nad precursors for improving maternal health and/or offspring health
US20180194824A1 (en) 2016-12-14 2018-07-12 University Of Iowa Research Foundation Musclin peptides and methods of use thereof
AR110590A1 (es) 2016-12-27 2019-04-10 Biogen Ma Inc Activador de nrf2
CN110337437B (zh) 2016-12-28 2023-02-03 达特神经科学有限公司 作为pde2抑制剂的取代的吡唑并嘧啶酮化合物
US10710957B2 (en) 2017-01-09 2020-07-14 University Of Central Florida Research Foundation, Inc. Motuporamine derivatives as antimicrobial agents and antibiotic enhancers against resistant gram-negative bacteria
US20180230105A1 (en) 2017-01-13 2018-08-16 Regents Of The University Of Minnesota Therapeutic compounds
CN110325508B (zh) 2017-01-20 2023-06-30 加利福尼亚大学董事会 雄激素受体的n-末端结构域的抑制剂
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
EP3573957B1 (de) 2017-01-24 2023-04-26 Rivara, Mirko Zusammensetzungen und verfahren zur blockierung von natriumkanälen
EP3573968A1 (de) 2017-01-30 2019-12-04 Biogen MA Inc. Nrf2-aktivator
WO2018140738A1 (en) 2017-01-30 2018-08-02 Biogen Ma Inc. Nrf 2 activator
WO2018148204A1 (en) 2017-02-07 2018-08-16 Biogen Ma Inc. Ask1 inhibiting agents
WO2018150276A2 (en) 2017-02-16 2018-08-23 Universidad San Sebastian The combination of cotinine plus antioxidant for treatment-resistant depression and correction of astrocytes functional deficit induced by depression and other neuropathological conditions
CN110770224B (zh) 2017-03-10 2022-11-18 罗格斯新泽西州立大学 作为外排泵抑制剂的吲哚衍生物
US11180459B2 (en) 2017-03-10 2021-11-23 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
US11938114B2 (en) 2017-03-10 2024-03-26 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
JOP20190233A1 (ar) 2017-04-14 2019-10-02 Biogen Ma Inc نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون
US10294264B2 (en) 2017-04-21 2019-05-21 Warsaw Orthopedic, Inc. Oxysterol-therapeutic agent derivative for bone healing
CA3063174A1 (en) 2017-05-12 2018-11-15 Innovus Pharmaceuticals, Inc. Therapeutic methods and compositions
US10434106B2 (en) 2017-05-19 2019-10-08 Warsaw Orthopedic, Inc. Oxysterol-statin compounds for bone growth
JP2020520949A (ja) 2017-05-22 2020-07-16 ユニバーシティ オブ ヴァージニア パテント ファウンデーションUniversity Of Verginia Patent Foundation 組成物、並びにミトコンドリア脱共役剤を調製及び使用する方法
EP3630109A4 (de) 2017-05-26 2021-03-17 Rutgers, the State University of New Jersey Inhibitoren für bakterielle abflusspumpen
MX2019014400A (es) 2017-06-02 2020-02-10 Merck Patent Gmbh Inmunoglobulinas que se unen a adamts.
BR112019025392A2 (pt) 2017-06-02 2020-07-07 Ablynx N.V. imunoglobulinas de ligação ao agrecano
US20200190216A1 (en) 2017-06-02 2020-06-18 Merck Patent Gmbh Mmp13 binding immunoglobulins
AU2018277102A1 (en) 2017-06-02 2019-12-19 Ablynx N.V. Polypeptides binding ADAMTS5, MMP13 and Aggrecan
AR112027A1 (es) 2017-06-15 2019-09-11 Biocryst Pharm Inc Inhibidores de alk 2 quinasa que contienen imidazol
US11396523B2 (en) 2017-06-22 2022-07-26 University Of Virginia Patent Foundation Proton activated atomic medicine
ES2968421T3 (es) 2017-06-23 2024-05-09 San Diego State Univ Research Foundation Atropisomerismo para la selectividad potenciada de inhibidor de cinasa
WO2019005841A1 (en) 2017-06-26 2019-01-03 Rutgers, The State University Of New Jersey THERAPEUTIC COMPOUNDS AND METHODS FOR TREATING INFECTION
JP7213863B2 (ja) 2017-07-12 2023-01-27 ダート・ニューロサイエンス・エルエルシー Pde7阻害剤としての置換ベンゾオキサゾール及びベンゾフラン化合物
CN107446050A (zh) 2017-08-11 2017-12-08 百奥泰生物科技(广州)有限公司 Trop2阳性疾病治疗的化合物及方法
WO2019046467A1 (en) 2017-08-29 2019-03-07 Rutgers, The State University Of New Jersey INDAZOLES THERAPEUTIC
WO2019147308A2 (en) 2017-08-30 2019-08-01 Arizona Board Of Regents On Behalf Of Arizona State University Rna nanostructures and methods of making and using rna nanostructures
EP3691644A4 (de) 2017-10-06 2021-06-30 Blue Therapeutics, Inc. Verfahren zur behandlung von akuten oder chronischen schmerzen
KR20200070334A (ko) 2017-10-16 2020-06-17 아라곤 파마슈티컬스, 인코포레이티드 비-전이성 거세-저항성 전립선암의 치료를 위한 항-안드로겐
US11565094B2 (en) 2017-10-17 2023-01-31 The Methodist Hospital System Delivery devices
EP3713913A1 (de) 2017-11-21 2020-09-30 Biogen MA Inc. Als nrf2-aktivatoren verwendbare tetrahydronaphthalinderivate
CA3120971A1 (en) 2017-11-27 2019-05-31 Dart Neuroscience, Llc Substituted furanopyrimidine compounds as pde1 inhibitors
EP3716956B1 (de) 2017-11-29 2024-06-26 The Cleveland Clinic Foundation Antitumor-tet2-modulierende verbindungen
CA3083190A1 (en) 2017-11-30 2019-06-06 Cytogel Pharma, Llc Novel analgesic pharmaceutical formulations and uses thereof
WO2019112885A1 (en) 2017-12-07 2019-06-13 The Cleveland Clinic Foundation Treatment of steroid-resistant disease using an anthocyanin and a corticosteroid
US11242533B2 (en) 2018-01-10 2022-02-08 Arizona Board Of Regents On Behalf Of Arizona State University RNA-nanostructured double robots and methods of use thereof
US10738093B2 (en) 2018-01-25 2020-08-11 The Hong Kong University Of Science And Technology Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
CN112118837B (zh) 2018-02-13 2024-07-09 罗格斯新泽西州立大学 抗菌剂:o-烷基氘化派洛宁
WO2019168688A2 (en) 2018-02-15 2019-09-06 Senhwa Biosciences, Inc. Quinolone analogs and their salts, compositions, and method for their use
US11890352B2 (en) 2018-02-27 2024-02-06 University Of Virginia Patent Foundation Plectin-targeted liposomes/PARP inhibitor in the treatment of cancer
US11365191B2 (en) 2018-02-28 2022-06-21 Dart Neuroscience, Llc Substituted cyclohexyl compounds as NOP inhibiiors
WO2019173507A1 (en) 2018-03-06 2019-09-12 Rutgers, The State University Of New Jersey Antibacterial agents : arylalkylcarboxamido phloroglucinols
WO2019178267A2 (en) 2018-03-13 2019-09-19 University Of Iowa Research Foundation Inductive regeneration of the airway by transcriptional factor modulation of glandular myoepithelial stem cells
WO2019178191A1 (en) 2018-03-14 2019-09-19 Biogen Ma Inc. O-glycoprotein-2-acetamido-2-deoxy-3-d-glycopyranosidase inhibitors
TW202010742A (zh) 2018-04-06 2020-03-16 美商百歐克斯製藥公司 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑
CA3097752A1 (en) 2018-04-20 2019-10-24 Virginia Tech Intellectual Properties, Inc. Imidazopyridines useful as mitochondrial uncouplers
WO2020036654A2 (en) 2018-04-27 2020-02-20 Arizona Board Of Regents On Behalf Of Arizona State University Highly knotted molecular topologies from single-stranded nucleic acids
US10899753B2 (en) 2018-05-14 2021-01-26 Biogen Ma Inc. Inhibiting agents for Bruton's tyrosine kinase
MX2020013895A (es) 2018-06-27 2021-07-21 Biogen Ma Inc Agentes inhibidores de ask1.
BR112021000316A2 (pt) 2018-07-09 2021-04-06 Taiwan Liposome Co. Ltd Métodos para reduzir complicações de esteroide intra-articular
SG11202012464WA (en) 2018-07-11 2021-01-28 H Lee Moffitt Cancer Center And Research Institute Inc Dimeric immuno-modulatory compounds against cereblon-based mechanisms
US10898460B1 (en) 2018-07-20 2021-01-26 University Of South Florida Leishmania inhibitors
WO2020028814A1 (en) 2018-08-03 2020-02-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Allosteric inhibitor of wee1 kinase
WO2020036946A1 (en) 2018-08-14 2020-02-20 Biogen Ma Inc. Pyridine macrocycle compounds as ask1 inhibiting agents
MX2021001783A (es) 2018-08-14 2021-08-11 Biogen Ma Inc Agentes inhibidores de ask1.
US11332499B2 (en) 2018-08-16 2022-05-17 Regents Of The University Of Minnesota Cyclic peptides and methods of use thereof
JP2022500453A (ja) 2018-09-13 2022-01-04 ミネアムリタ セラピューティクス, エルエルシー 線維症、nash、及び、nafldを治療する方法での使用のためのトリプトリド、及び、そのプロドラッグ
JP2022500472A (ja) 2018-09-19 2022-01-04 バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. O−糖タンパク質−2−アセトアミド−2−デオキシ−3−d−グルコピラノシダーゼ阻害剤
JP7476214B2 (ja) 2018-10-15 2024-04-30 バイオジェン・エムエイ・インコーポレイテッド ブルトン型チロシンキナーゼ阻害剤の結晶多形
US11696957B2 (en) 2018-10-17 2023-07-11 Sunstate Biosciences, LLC Single protein-encapsulated pharmaceutics for enhancing therapeutic effects
US20220002238A1 (en) 2018-11-07 2022-01-06 Regents Of The University Of Minnesota Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
EP3876827B1 (de) 2018-11-09 2023-09-27 The University of Rochester Verfahren zur bestimmung einer behandlung von krebs auf basis einer antwortvorhersage mittels lichtstreuungstechnologie
CA3120970A1 (en) 2018-11-26 2020-06-04 Denali Therapeutics Inc. Methods for treating dysregulated lipid metabolism
AR117252A1 (es) 2018-12-05 2021-07-21 Biogen Ma Inc Inhibidores de o-glucoproteína-2-acetamido-2-desoxi-3-d-glucopiranosidasa de morfolinilo, piperazinilo, oxazepanilo y diazepanilo
AU2020208192A1 (en) 2019-01-14 2021-08-05 Regents Of The University Of Minnesota CD200AR ligands for cancer immunotherapy
US20220106305A1 (en) 2019-02-04 2022-04-07 Biogen Ma Inc. Bicyclic ether o-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors
US20220259197A1 (en) 2019-03-08 2022-08-18 Biogen Ma Inc. Azetidinyl o-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors
WO2020225779A1 (en) 2019-05-09 2020-11-12 Istituto Pasteur Italia - Fondazione Cenci Bolognetti Rig-i agonists for cancer treatment and immunotherapy
US20220259194A1 (en) 2019-05-15 2022-08-18 Biogen Ma Inc. Inhibiting agents for bruton's tyrosine kinase
WO2020257658A1 (en) 2019-06-20 2020-12-24 University Of Iowa Research Foundation Nanoparticles comprising quinone w methides and compositions for use
WO2020263989A1 (en) 2019-06-24 2020-12-30 University Of Iowa Research Foundation Jnk inhibitors as anticancer agents
BR112022002060A2 (pt) 2019-08-06 2022-06-07 Biocryst Pharm Inc Síntese de escala de processo de um inibidor de calicreína de plasma
BR112022006739B1 (pt) 2019-10-10 2024-01-23 Cellectar Biosciences, Inc Conjugados fosfolipídio-flavagina e métodos de uso do mesmo para terapia direcionada a câncer
JP2022553376A (ja) 2019-10-25 2022-12-22 アクセント・セラピューティクス・インコーポレイテッド Mettl3モジュレーター
US20230060003A1 (en) 2019-10-29 2023-02-23 Biogen Ma Inc. Spirocyclic o-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors
US20220411429A1 (en) 2019-10-30 2022-12-29 Biogen Ma Inc. Condensed pyridazine or pyrimidine as btk inhibitors
JP2023501236A (ja) 2019-10-30 2023-01-18 バイオジェン・エムエイ・インコーポレイテッド ブルトン型チロシンキナーゼに対する阻害剤としての縮合型二複素環
WO2021133894A1 (en) 2019-12-23 2021-07-01 Biogen Ma Inc. Btk inhibitors
US20230053688A1 (en) 2020-01-10 2023-02-23 Cornell University Methods to alter latency in ebv+ malignancies
WO2021236578A1 (en) 2020-05-18 2021-11-25 Salk Institute For Biological Studies Chromen-4-one derivatives, such as e.g. flavones, for use as ck2 inhibitors for the treatment of neuroinflammation
TWI776584B (zh) 2020-07-10 2022-09-01 長庚醫療財團法人林口長庚紀念醫院 β-1腎上腺素受體拮抗劑用於製備減少表皮生長因子受體抑制劑誘導的上皮細胞損傷以及抑制癌細胞的組合物之用途
US11529335B2 (en) 2020-07-31 2022-12-20 University Of Iowa Research Foundation Compositions and methods for treating cancer
WO2022032019A1 (en) 2020-08-07 2022-02-10 Biogen Ma Inc. Btk inhibitors
EP4208455A1 (de) 2020-09-02 2023-07-12 The United States of America, as represented by the Secretary, Department of Health and Human Services Lzk-gerichtete degrader und verfahren zur verwendung
AU2021360789A1 (en) 2020-10-14 2023-06-15 Accent Therapeutics, Inc. Mettl3 modulators
CN117098763A (zh) 2021-01-07 2023-11-21 渤健马萨诸塞州股份有限公司 Tyk2抑制剂
KR20230148180A (ko) 2021-02-22 2023-10-24 리전츠 오브 더 유니버스티 오브 미네소타 면역조절제 및 면역조절제 컨쥬게이트
TWI796023B (zh) 2021-03-10 2023-03-11 長庚醫療財團法人 藥物組合物及其用途
WO2022212893A1 (en) 2021-04-02 2022-10-06 Biogen Ma Inc. Combination treatment methods of multiple sclerosis
US11780828B2 (en) 2021-05-04 2023-10-10 Regents Of The University Of Minnesota Contraceptive compounds and methods
CA3217417A1 (en) 2021-05-05 2022-11-10 Kevin M. Guckian Compounds for targeting degradation of bruton's tyrosine kinase
CA3224994A1 (en) 2021-06-22 2022-12-29 Dana-Farber Cancer Institute, Inc. (1h-pyrrolo[2,3-b]pyridin-1-yl)pyrimidin-2-yl-amino-phenyl--acrylamide inhibitors of egfr for use in the treatment of brain tumors
WO2022271951A1 (en) 2021-06-23 2022-12-29 University Of Iowa Research Foundation Sustained release formulations comprising a selective androgen receptor modulator
WO2023283372A1 (en) 2021-07-07 2023-01-12 Biogen Ma Inc. Compounds for targeting degradation of irak4 proteins
AU2022308734A1 (en) 2021-07-07 2024-02-22 Biogen Ma Inc. Compounds for targeting degradation of irak4 proteins
KR20240055041A (ko) 2021-09-01 2024-04-26 더 유나이티드 스테이츠 오브 아메리카, 애즈 레프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 혼합 계통 키나제 억제제 및 억제제의 사용 방법
WO2023081237A1 (en) 2021-11-03 2023-05-11 Regents Of The University Of Minnesota Toll-like receptor agonists and antagonists and uses thereof
WO2023086521A1 (en) 2021-11-10 2023-05-19 Biogen Ma Inc. Btk inhibitors
WO2023086575A1 (en) 2021-11-12 2023-05-19 Biogen Ma Inc. Btk inhibitors
US20240200078A1 (en) 2021-11-18 2024-06-20 Cornell University Microrna-dependent mrna switches for tissue-specific mrna-based therapies
WO2023130022A2 (en) 2021-12-29 2023-07-06 University Of Iowa Research Foundation Cystatin rna compositions for tissue engineering
WO2023220046A1 (en) 2022-05-10 2023-11-16 Biogen Ma Inc. Tyk2 inhibitors
WO2023220049A1 (en) 2022-05-10 2023-11-16 Biogen Ma Inc. Crystalline polymorphs of n-methyl-n-((1s,3s)-3-methyl-3-((6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide
WO2024006493A1 (en) 2022-07-01 2024-01-04 Biogen Ma Inc. Tyk2 inhibitors
WO2024006977A1 (en) 2022-07-01 2024-01-04 University Of Southern California Analgesic delta opioid receptor bitopic ligands
WO2024009283A1 (en) 2022-07-07 2024-01-11 University Of Southern California At2 antagonists for non-addictive pain relief
WO2024011214A1 (en) 2022-07-08 2024-01-11 Actio Biosciences, Inc. Therapeutic compounds and methods
WO2024100093A1 (en) 2022-11-09 2024-05-16 Merck Patent Gmbh Toll-like receptor 7 agonists as immune-stimulators to elicit the innate antitumor immunity
WO2024112932A1 (en) 2022-11-23 2024-05-30 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
WO2024124023A2 (en) 2022-12-07 2024-06-13 Rutgers, The State University Of New Jersey Carbonic anhydrase enzyme inhibitors and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148885A (en) * 1973-09-25 1979-04-10 Institut Merieux Immunostimulant medicine
US4594238A (en) * 1980-08-08 1986-06-10 Regents Of University Of Minnesota Inhibition of undesired effect of platinum compounds
US4645661A (en) * 1984-06-29 1987-02-24 St. Jude Children's Research Hospital Method for alleviating cisplatin-induced nephrotoxicity and dithiocarbamate compounds for effecting same

Also Published As

Publication number Publication date
NZ230622A (en) 1991-09-25
AU623184B2 (en) 1992-05-07
AU4335589A (en) 1990-04-02
US4938949A (en) 1990-07-03
WO1990002550A1 (en) 1990-03-22
ATE119771T1 (de) 1995-04-15
EP0433393A4 (en) 1992-01-15
DK44791D0 (da) 1991-03-12
EP0433393A1 (de) 1991-06-26
JPH04500676A (ja) 1992-02-06
DK44791A (da) 1991-05-10
EP0433393B1 (de) 1995-03-15

Similar Documents

Publication Publication Date Title
DE68921760D1 (de) Behandlung von beschädigtem knochenmark und dosierungseinheiten dafür.
EP0139535B1 (de) Zusammensetzungen zur Bekämpfung von Toxaemia
DE69627651T2 (de) Formulierungen und zusammensetzungen von in wasser schwer löslichen camptothecinderivaten
FI872864A0 (fi) Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
IL93050A0 (en) Pyrazolopyridine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0139534B1 (de) Zusammensetzungen zur propylaktischen Behandlung von Osteitis und Osteomyelitis
DK98089A (da) Medikament-lipid-systemer med lav toxicitet
MX9203417A (es) Compuestos de diarilo antiateroescleroticos.
KR910004191A (ko) 신질환치료제
CA2166704C (en) Arsenic medicaments for the treatment of chronic fatigue syndrome
WO1991002529A2 (en) Product and method for killing abnormal vertebrate cells
KR960034200A (ko) 항편두통성 인돌릴알킬-피리딘일 및 피리미딘일피페라진의 1,2,5-티아디아졸 유도체
KR920703112A (ko) 의약품 조성물
KR910018348A (ko) 술포닐아미노치환 비시클로환계 히드록삼산 유도체
KR890008136A (ko) 항균성 9-데옥소-9a-알릴 및 프로파길-9a-아자-9a-호모에리트로 마이신 A 유도체
IL81337A (en) Heptanoyl-glu-asp-ala-amino acid immunostimulants,process for their preparation and pharmaceutical compositions containing them
KR880004810A (ko) 소화성 궤양 치료제
KR890003372A (ko) 피리미도[2,1-b] 벤조티아졸 유도체로된 동맥경화 치료의약
KR100190869B1 (ko) 아목시실린 및 클라부란산을 포함하여 구성되는 수의학적 조성물 및 그를 사용한 치료방법
KR910000785A (ko) 9-r-아자사이클릭 에리트로마이신 항생제
KR910018026A (ko) α-페닐-α피리딜알칸산 유도체를 함유하는 배뇨장애증상 치료제
KR890014116A (ko) 고혈압치료 혼합물
KR890003678A (ko) 부정맥 치료제
KR880008813A (ko) 체내분비액중 위산과다증 치료약제 및 치료방법
KR900013948A (ko) 개량된 화학적 화합물

Legal Events

Date Code Title Description
8332 No legal effect for de