MX2019014400A - Inmunoglobulinas que se unen a adamts. - Google Patents

Inmunoglobulinas que se unen a adamts.

Info

Publication number
MX2019014400A
MX2019014400A MX2019014400A MX2019014400A MX2019014400A MX 2019014400 A MX2019014400 A MX 2019014400A MX 2019014400 A MX2019014400 A MX 2019014400A MX 2019014400 A MX2019014400 A MX 2019014400A MX 2019014400 A MX2019014400 A MX 2019014400A
Authority
MX
Mexico
Prior art keywords
immunoglobulins
polypeptides
constructs
nucleic acids
host cells
Prior art date
Application number
MX2019014400A
Other languages
English (en)
Inventor
Hermans Guy
Guehring Hans
Ange Buyse Marie-
Lindemann Sven
Guenther Ralf
Kellner Roland
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2019014400A publication Critical patent/MX2019014400A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Abstract

La presente invención se refiere a inmunoglobulinas que se unen a ADAMTS5 y más en particular a polipéptidos, que comprenden o consisten esencialmente de una o más de tales inmunoglobulinas. La invención también se refiere a constructos que comprenden dichas inmunoglobulinas, tales como dominios variables sencillos de inmunoglobulina (ISVD) o polipéptidos, así como ácidos nucleicos que codifican tales inmunoglobulinas o polipéptidos; a métodos para preparar tales inmunoglobulinas, polipéptidos y constructos; para hospedar células que expresan o sean capaces de expresar tales inmunoglobulinas o polipéptidos; a las composiciones, y en particular para composiciones farmacéuticas, que comprenden tales inmunoglobulinas, polipéptidos, constructos, ácidos nucleicos y/o células hospederas; y para usos de inmunoglobulinas, polipéptidos, constructos, ácidos nucleicos, células hospederas y/o composiciones, en particular con propósitos profilácticos y/o terapéuticos, tales como los propósitos profilácticos y/o terapéuticos mencionados en este documento. Otros aspectos, modalidades, ventajas y aplicaciones de la invención quedarán claros a partir de la descripción adicional en este documento.
MX2019014400A 2017-06-02 2018-06-04 Inmunoglobulinas que se unen a adamts. MX2019014400A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17174403 2017-06-02
PCT/EP2018/064665 WO2018220234A1 (en) 2017-06-02 2018-06-04 Adamts binding immunoglobulins

Publications (1)

Publication Number Publication Date
MX2019014400A true MX2019014400A (es) 2020-02-10

Family

ID=59014502

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019014400A MX2019014400A (es) 2017-06-02 2018-06-04 Inmunoglobulinas que se unen a adamts.

Country Status (12)

Country Link
US (2) US11261260B2 (es)
EP (2) EP3630847A1 (es)
JP (2) JP2020525410A (es)
KR (1) KR20200012935A (es)
CN (1) CN111032695A (es)
AU (1) AU2018277343A1 (es)
BR (1) BR112019024333A2 (es)
CA (1) CA3063293A1 (es)
IL (1) IL270908A (es)
MX (1) MX2019014400A (es)
TW (1) TWI802576B (es)
WO (1) WO2018220234A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
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AU2022266254A1 (en) 2021-04-30 2023-12-14 Merck Patent Gmbh Methods for the administration of adamts binding immunoglobulins

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Also Published As

Publication number Publication date
IL270908A (en) 2020-01-30
BR112019024333A2 (pt) 2020-07-28
TW201920287A (zh) 2019-06-01
AU2018277343A1 (en) 2020-01-02
JP2023123448A (ja) 2023-09-05
US20220289860A1 (en) 2022-09-15
KR20200012935A (ko) 2020-02-05
CA3063293A1 (en) 2018-12-06
EP4272822A2 (en) 2023-11-08
CN111032695A (zh) 2020-04-17
RU2019143075A3 (es) 2021-11-12
EP4272822A3 (en) 2024-03-27
EP3630847A1 (en) 2020-04-08
US11261260B2 (en) 2022-03-01
TWI802576B (zh) 2023-05-21
JP2020525410A (ja) 2020-08-27
RU2019143075A (ru) 2021-07-13
WO2018220234A1 (en) 2018-12-06
US20200317802A1 (en) 2020-10-08

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