MX2019014397A - Polipeptidos que enlazan adamts5, mmp13 y agrecano. - Google Patents
Polipeptidos que enlazan adamts5, mmp13 y agrecano.Info
- Publication number
- MX2019014397A MX2019014397A MX2019014397A MX2019014397A MX2019014397A MX 2019014397 A MX2019014397 A MX 2019014397A MX 2019014397 A MX2019014397 A MX 2019014397A MX 2019014397 A MX2019014397 A MX 2019014397A MX 2019014397 A MX2019014397 A MX 2019014397A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptides
- immunoglobulins
- constructs
- mmp13
- aggrecan
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a polipéptidos que enlazan a Agrecano así como ADAMTS5 y/o MMP13, más en particular a polipéptidos que comprenden o consisten esencialmente de inmunoglobulinas que enlazan a Agrecano así como inmunoglobulinas que enlazan a ADAMTS5 y/o inmunoglobulinas que enlazan a MMP13 (también referida en la presente como"polipéptidos de la invención", y "inmunoglobulinas de la invención", respectivamente). La invención también se refiere a constructos que comprenden estas inmunoglobulinas, tal como dominios variables individuales de inmunoglobulina (ISVDs) o polipéptidos así como ácidos nucleicos que codifican estas inmunoglobulinas o polipéptidos (también referido en la presente como "ácidos nucleicos de la invención"; a métodos para preparar estas inmunoglobulinas, polipéptidos y constructos; a las células hospederas que expresan o son capaces de expresar estas inmunoglobulinas o polipéptidos; a composiciones, y en particular a composiciones farmacéuticas, que comprenden estas inmunoglobulinas, polipéptidos, constructos, ácidos nucleicos y/o células hospederas; y a usos de inmunoglobulinas, polipéptidos, constructos, ácidos nucleicos, células hospederas y/o composiciones, en particular para propósitos profilácticos y/o terapéuticos, tal como los propósitos profilácticos y/o terapéuticos mencionados en la presente. Otros aspectos, modalidades, ventajas y aplicaciones de la invención serán claras a partir de la descripción adicional en la presente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17174404 | 2017-06-02 | ||
PCT/EP2018/064668 WO2018220236A1 (en) | 2017-06-02 | 2018-06-04 | Polypeptides binding adamts5, mmp13 and aggrecan |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019014397A true MX2019014397A (es) | 2020-02-10 |
Family
ID=59014503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019014397A MX2019014397A (es) | 2017-06-02 | 2018-06-04 | Polipeptidos que enlazan adamts5, mmp13 y agrecano. |
Country Status (12)
Country | Link |
---|---|
US (2) | US11813307B2 (es) |
EP (1) | EP3630817A1 (es) |
JP (1) | JP7249961B2 (es) |
KR (1) | KR20200015912A (es) |
CN (1) | CN110997717A (es) |
AU (1) | AU2018277102A1 (es) |
BR (1) | BR112019025147A2 (es) |
CA (1) | CA3064318A1 (es) |
IL (1) | IL270951A (es) |
MX (1) | MX2019014397A (es) |
TW (1) | TWI826376B (es) |
WO (1) | WO2018220236A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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MX350074B (es) * | 2011-06-23 | 2017-08-25 | Ablynx Nv | Tecnicas para predecir, detectar, y reducir la interferencia de proteinas no especificas en ensayos que implican dominios variables individuales de inmunoglobulina. |
BR112019008265A2 (pt) | 2016-11-28 | 2019-07-09 | Chugai Pharmaceutical Co Ltd | molécula de ligação ao ligante cuja atividade de li-gação ao ligante é ajustável |
CN110177875B (zh) | 2016-11-28 | 2023-11-28 | 中外制药株式会社 | 包含抗原结合结构域和运送部分的多肽 |
KR20200012935A (ko) | 2017-06-02 | 2020-02-05 | 메르크 파텐트 게엠베하 | Adamts 결합성 면역글로불린 |
BR112020010450A2 (pt) | 2017-11-28 | 2020-11-24 | Chugai Seiyaku Kabushiki Kaisha | polipeptídeo que inclui domínio de ligação a antígeno e seção transportadora |
JP7414736B2 (ja) | 2018-05-30 | 2024-01-16 | 中外製薬株式会社 | アグリカン結合ドメインおよび運搬部分を含むポリペプチド |
WO2024054922A1 (en) * | 2022-09-07 | 2024-03-14 | Synoa Therapeutics, Llc | Methods and compositions comprising novel bispecific antibodies |
WO2024133935A1 (en) | 2022-12-23 | 2024-06-27 | Ablynx Nv | Protein-based conjugation carriers |
WO2024170756A1 (en) | 2023-02-17 | 2024-08-22 | Ablynx N.V. | Polypeptides binding to the neonatal fc receptor |
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JP5354680B2 (ja) * | 2007-07-10 | 2013-11-27 | 塩野義製薬株式会社 | Mmp13に対する中和活性を有するモノクローナル抗体 |
US20090202474A1 (en) * | 2007-11-19 | 2009-08-13 | Wyeth | Expression of orphan gpr64 in inflammatory diseases |
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US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
MX350074B (es) | 2011-06-23 | 2017-08-25 | Ablynx Nv | Tecnicas para predecir, detectar, y reducir la interferencia de proteinas no especificas en ensayos que implican dominios variables individuales de inmunoglobulina. |
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WO2013109829A1 (en) * | 2012-01-20 | 2013-07-25 | Glaxosmithkline Intellectual Property Development Ltd | Anti-adamts4 antibodies and methods of treatment |
FR2996003B1 (fr) | 2012-09-25 | 2014-10-17 | Commissariat Energie Atomique | Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active |
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GB201617622D0 (en) | 2016-10-18 | 2016-11-30 | VIB VZW and Universiteit Gent | Means and methods to treat inflammation |
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2018
- 2018-06-04 EP EP18730691.5A patent/EP3630817A1/en active Pending
- 2018-06-04 AU AU2018277102A patent/AU2018277102A1/en active Pending
- 2018-06-04 KR KR1020197038466A patent/KR20200015912A/ko active IP Right Grant
- 2018-06-04 TW TW107119217A patent/TWI826376B/zh active
- 2018-06-04 CN CN201880049024.2A patent/CN110997717A/zh active Pending
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- 2018-06-04 BR BR112019025147-2A patent/BR112019025147A2/pt unknown
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RU2019143684A (ru) | 2021-07-13 |
US20240181006A1 (en) | 2024-06-06 |
JP2020523986A (ja) | 2020-08-13 |
TW201920291A (zh) | 2019-06-01 |
US11813307B2 (en) | 2023-11-14 |
BR112019025147A2 (pt) | 2020-06-23 |
IL270951A (en) | 2020-01-30 |
EP3630817A1 (en) | 2020-04-08 |
CN110997717A (zh) | 2020-04-10 |
RU2019143684A3 (es) | 2021-11-10 |
KR20200015912A (ko) | 2020-02-13 |
US20210008160A1 (en) | 2021-01-14 |
JP7249961B2 (ja) | 2023-03-31 |
AU2018277102A1 (en) | 2019-12-19 |
WO2018220236A1 (en) | 2018-12-06 |
TWI826376B (zh) | 2023-12-21 |
CA3064318A1 (en) | 2018-12-06 |
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