BR112022002060A2 - Síntese de escala de processo de um inibidor de calicreína de plasma - Google Patents
Síntese de escala de processo de um inibidor de calicreína de plasmaInfo
- Publication number
- BR112022002060A2 BR112022002060A2 BR112022002060A BR112022002060A BR112022002060A2 BR 112022002060 A2 BR112022002060 A2 BR 112022002060A2 BR 112022002060 A BR112022002060 A BR 112022002060A BR 112022002060 A BR112022002060 A BR 112022002060A BR 112022002060 A2 BR112022002060 A2 BR 112022002060A2
- Authority
- BR
- Brazil
- Prior art keywords
- process scale
- plasma kallikrein
- scale synthesis
- kallikrein inhibitor
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Health & Medical Sciences (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Abstract
síntese de escala de processo de um inibidor de calicreína de plasma. a presente invenção refere-se a métodos de preparar o composto (i) e seus sais. os métodos de preparar o composto (i) são adequados para uso em escala de processo. (i)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962883396P | 2019-08-06 | 2019-08-06 | |
PCT/US2020/044921 WO2021026182A1 (en) | 2019-08-06 | 2020-08-05 | Process-scale synthesis of a plasma kallikrein inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022002060A2 true BR112022002060A2 (pt) | 2022-06-07 |
Family
ID=74504082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022002060A BR112022002060A2 (pt) | 2019-08-06 | 2020-08-05 | Síntese de escala de processo de um inibidor de calicreína de plasma |
Country Status (20)
Country | Link |
---|---|
US (1) | US20220289683A1 (pt) |
EP (1) | EP4010320A4 (pt) |
JP (1) | JP2022543419A (pt) |
KR (1) | KR20220044276A (pt) |
CN (1) | CN114206839A (pt) |
AR (1) | AR119617A1 (pt) |
AU (1) | AU2020324422A1 (pt) |
BR (1) | BR112022002060A2 (pt) |
CA (1) | CA3149176A1 (pt) |
CL (2) | CL2022000264A1 (pt) |
CO (1) | CO2022002392A2 (pt) |
CR (1) | CR20220092A (pt) |
EC (1) | ECSP22016209A (pt) |
IL (1) | IL290113A (pt) |
JO (1) | JOP20220021A1 (pt) |
MX (1) | MX2022001608A (pt) |
PE (1) | PE20221009A1 (pt) |
TW (1) | TW202120481A (pt) |
UY (1) | UY38826A (pt) |
WO (1) | WO2021026182A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4180424A1 (en) | 2014-03-07 | 2023-05-17 | BioCryst Pharmaceuticals, Inc. | Substituted pyrazoles as human plasma kallikrein inhibitors |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
LU86084A1 (fr) | 1985-09-20 | 1987-04-02 | Faco Sa | Apparei de massage electrique |
US5102417A (en) | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US4800882A (en) | 1987-03-13 | 1989-01-31 | Cook Incorporated | Endovascular stent and delivery system |
US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
US4886062A (en) | 1987-10-19 | 1989-12-12 | Medtronic, Inc. | Intravascular radially expandable stent and method of implant |
US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
WO1990013332A1 (en) | 1989-05-11 | 1990-11-15 | Cedars-Sinai Medical Center | Stent with sustained drug delivery |
DE69110787T2 (de) | 1990-02-28 | 1996-04-04 | Medtronic Inc | Intraluminale prothese mit wirkstoffeluierung. |
US5419760A (en) | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
US5429634A (en) | 1993-09-09 | 1995-07-04 | Pdt Systems | Biogenic implant for drug delivery and method |
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
WO2003016282A2 (en) * | 2001-08-13 | 2003-02-27 | E.I. Du Pont De Nemours And Company | Substituted 1h-dihydropyrazoles, their preparation and use |
US6770729B2 (en) | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
EP2484676B1 (de) * | 2008-12-18 | 2015-01-21 | Bayer CropScience AG | Tetrazolsubstituierte Anthranilsäureamide als Pestizide |
EP4180424A1 (en) * | 2014-03-07 | 2023-05-17 | BioCryst Pharmaceuticals, Inc. | Substituted pyrazoles as human plasma kallikrein inhibitors |
-
2020
- 2020-08-05 PE PE2022000188A patent/PE20221009A1/es unknown
- 2020-08-05 MX MX2022001608A patent/MX2022001608A/es unknown
- 2020-08-05 CN CN202080055475.4A patent/CN114206839A/zh active Pending
- 2020-08-05 CA CA3149176A patent/CA3149176A1/en active Pending
- 2020-08-05 JO JOP/2022/0021A patent/JOP20220021A1/ar unknown
- 2020-08-05 AU AU2020324422A patent/AU2020324422A1/en active Pending
- 2020-08-05 US US17/632,585 patent/US20220289683A1/en active Pending
- 2020-08-05 TW TW109126552A patent/TW202120481A/zh unknown
- 2020-08-05 KR KR1020227003932A patent/KR20220044276A/ko active Search and Examination
- 2020-08-05 BR BR112022002060A patent/BR112022002060A2/pt unknown
- 2020-08-05 WO PCT/US2020/044921 patent/WO2021026182A1/en unknown
- 2020-08-05 EP EP20850499.3A patent/EP4010320A4/en active Pending
- 2020-08-05 CR CR20220092A patent/CR20220092A/es unknown
- 2020-08-05 JP JP2022506947A patent/JP2022543419A/ja active Pending
- 2020-08-06 UY UY0001038826A patent/UY38826A/es unknown
- 2020-08-06 AR ARP200102248A patent/AR119617A1/es unknown
-
2022
- 2022-01-25 IL IL290113A patent/IL290113A/en unknown
- 2022-02-01 CL CL2022000264A patent/CL2022000264A1/es unknown
- 2022-02-28 CO CONC2022/0002392A patent/CO2022002392A2/es unknown
- 2022-03-03 EC ECSENADI202216209A patent/ECSP22016209A/es unknown
-
2023
- 2023-03-30 CL CL2023000942A patent/CL2023000942A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AR119617A1 (es) | 2021-12-29 |
CO2022002392A2 (es) | 2022-04-08 |
AU2020324422A1 (en) | 2022-03-17 |
ECSP22016209A (es) | 2022-06-30 |
CR20220092A (es) | 2022-06-03 |
MX2022001608A (es) | 2022-03-11 |
UY38826A (es) | 2021-02-26 |
JOP20220021A1 (ar) | 2023-01-30 |
CN114206839A (zh) | 2022-03-18 |
EP4010320A1 (en) | 2022-06-15 |
TW202120481A (zh) | 2021-06-01 |
IL290113A (en) | 2022-03-01 |
KR20220044276A (ko) | 2022-04-07 |
WO2021026182A1 (en) | 2021-02-11 |
PE20221009A1 (es) | 2022-06-15 |
CL2022000264A1 (es) | 2022-10-21 |
JP2022543419A (ja) | 2022-10-12 |
CL2023000942A1 (es) | 2023-11-24 |
US20220289683A1 (en) | 2022-09-15 |
CA3149176A1 (en) | 2021-02-11 |
EP4010320A4 (en) | 2023-08-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2022000603A1 (es) | Inhibidores prmt5 cooperativos de mta | |
BR112015030515A2 (pt) | intensificadores de inibidores de homólogo 2 de zeste | |
BR112018011788A2 (pt) | formas sólidas de éster etílico de ácido (2r,4s)-5-(bifenil-4-il)-4-[(3-carboxipropionil)amino]-2-metil-pentanoico, seus sais e um método de preparação | |
CO2021010930A2 (es) | Hidroxipiridoxazepinas como activadores de nrf2 | |
CL2017002354A1 (es) | Compuestos derivados de heteroarilos bicíclicos fusionados con actividad como inhibidores de phd. | |
BR122020014933B8 (pt) | Compostos, composições farmacêuticas, benzenossulfonatos, forma a de ácido p-toluenossulfônico, forma b de ácido p-toluenssulfônico, forma i do ácido naftalenodissulfônico e forma ii do ácido naftalendissulfônico | |
BR112017028616A2 (pt) | acentuador de inibidores de homólogo de zeste 2 | |
BR112023003580A2 (pt) | Compostos heterocíclicos | |
BR112019025028A2 (pt) | Método para preparar um composto. | |
BR112022001365A2 (pt) | Formas cristalinas de um inibidor de cd73 | |
CL2021000903A1 (es) | Nhibidores de ror gamma (solicitud divisional de la solicitud 217-2020 | |
BR112015024109A2 (pt) | derivados de ureia e seu uso como inibidores de proteína de ligação de ácidos graxos (fabp) | |
BR112023023527A2 (pt) | Inibidores de nlrp3 | |
BR112023022755A2 (pt) | Composto cíclico possuindo efeito inibidor seletivo para kras, mas não para hras e nras | |
BR112014019585A8 (pt) | Forma sólida de um composto, composição farmacêutica e cápsula em gel | |
CO2021007172A2 (es) | Sales cristalinas de un inhibidor de calicreína plasmática | |
BR112022002060A2 (pt) | Síntese de escala de processo de um inibidor de calicreína de plasma | |
BR112018077390A2 (pt) | sais cristalinos de peptídeo epoxicentona inibidor de imunoproteassoma | |
BR112023001053A2 (pt) | Processo de clorantraniliprole aprimorado através do uso de um intermediário de cristal | |
BR112018071748A2 (pt) | processo para a preparação de compostos herbicidas | |
BR112018071009A2 (pt) | processo para a preparação de pamoato de pirvínio e formas cristalinas do mesmo | |
BR112019022265A2 (pt) | silanos contendo benzotiazol, método para a preparação e uso dos mesmos | |
BR112021022347A8 (pt) | Processos e intermediários para a preparação de um inibidor de btk | |
BR112016002724A8 (pt) | composto, processo para a preparação de um composto, composição farmacêutica e uso de composto | |
BR112022003186A2 (pt) | Processo para preparar intermediário de inibidor de e-selectina |