DD203052A5 - Verfahren zur herstellung von 9-(1,3-dihydroxy-2-propoxy-methyl)-guanin, dessen salzen und bestimmten benzylderivaten desselben - Google Patents

Verfahren zur herstellung von 9-(1,3-dihydroxy-2-propoxy-methyl)-guanin, dessen salzen und bestimmten benzylderivaten desselben Download PDF

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Publication number
DD203052A5
DD203052A5 DD82240075A DD24007582A DD203052A5 DD 203052 A5 DD203052 A5 DD 203052A5 DD 82240075 A DD82240075 A DD 82240075A DD 24007582 A DD24007582 A DD 24007582A DD 203052 A5 DD203052 A5 DD 203052A5
Authority
DD
German Democratic Republic
Prior art keywords
compound
guanine
formula
dihydroxy
propoxymethyl
Prior art date
Application number
DD82240075A
Other languages
German (de)
English (en)
Inventor
Julien P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD203052(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DD203052A5 publication Critical patent/DD203052A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DD82240075A 1981-05-21 1982-05-21 Verfahren zur herstellung von 9-(1,3-dihydroxy-2-propoxy-methyl)-guanin, dessen salzen und bestimmten benzylderivaten desselben DD203052A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (1)

Publication Number Publication Date
DD203052A5 true DD203052A5 (de) 1983-10-12

Family

ID=23017790

Family Applications (2)

Application Number Title Priority Date Filing Date
DD82256251A DD213218A5 (de) 1981-05-21 1982-05-21 Verfahren zur herstellung von 9-(1,3-dihydroxy-2-propoxymethyl)-guaninderivaten
DD82240075A DD203052A5 (de) 1981-05-21 1982-05-21 Verfahren zur herstellung von 9-(1,3-dihydroxy-2-propoxy-methyl)-guanin, dessen salzen und bestimmten benzylderivaten desselben

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DD82256251A DD213218A5 (de) 1981-05-21 1982-05-21 Verfahren zur herstellung von 9-(1,3-dihydroxy-2-propoxymethyl)-guaninderivaten

Country Status (33)

Country Link
US (1) US4355032B2 (ja)
EP (1) EP0066208B1 (ja)
JP (2) JPS57203086A (ja)
KR (1) KR890004663B1 (ja)
AR (1) AR244227A1 (ja)
AT (1) ATE15899T1 (ja)
AU (1) AU572086B2 (ja)
BR (1) BR8202931A (ja)
CA (3) CA1305141C (ja)
CS (4) CS235044B2 (ja)
DD (2) DD213218A5 (ja)
DE (1) DE3266644D1 (ja)
DK (2) DK150304C (ja)
ES (7) ES8404355A1 (ja)
FI (1) FI73682C (ja)
GR (1) GR76459B (ja)
HK (1) HK67088A (ja)
HU (2) HU188000B (ja)
IE (1) IE53731B1 (ja)
IL (1) IL65836A (ja)
IN (1) IN156469B (ja)
LU (1) LU88334I2 (ja)
MY (1) MY8700793A (ja)
NL (2) NL930022I1 (ja)
NO (2) NO161740C (ja)
NZ (1) NZ200691A (ja)
PH (1) PH17975A (ja)
PL (4) PL136579B1 (ja)
PT (1) PT74934B (ja)
RO (2) RO84860B (ja)
SG (1) SG81687G (ja)
SU (1) SU1176841A3 (ja)
ZA (1) ZA823532B (ja)

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US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
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SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
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CA2005815C (en) * 1988-12-19 1999-08-03 Wellcome Foundation Limited (The) Antiviral acyclic nucleoside derivatives
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
ATE178605T1 (de) * 1993-06-23 1999-04-15 Merrell Pharma Inc Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
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US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
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US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
CS594082A2 (en) * 1981-08-11 1989-08-14 Wellcome Found Method of antiviral effective 2-amino-9-/(2-hydroxy-1-hydroxymethyl-ethoxy)methyl/purines production

Also Published As

Publication number Publication date
RO87387A (ro) 1985-08-31
NL930139I2 (nl) 1997-07-01
ZA823532B (en) 1983-03-30
NL930139I1 (nl) 1993-11-01
ATE15899T1 (de) 1985-10-15
CS235044B2 (en) 1985-04-16
KR890004663B1 (ko) 1989-11-24
PH17975A (en) 1985-02-22
RO87387B (ro) 1985-08-31
DK150304C (da) 1988-01-04
NL930022I1 (nl) 1993-05-03
IE53731B1 (en) 1989-02-01
IN156469B (ja) 1985-08-10
CS235043B2 (en) 1985-04-16
FI821794A0 (fi) 1982-05-20
JPH0529399B2 (ja) 1993-04-30
PL242101A1 (en) 1984-07-16
DK149001C (da) 1988-11-28
HU186514B (en) 1985-08-28
JPS57203086A (en) 1982-12-13
HK67088A (en) 1988-09-02
PL246770A1 (en) 1984-08-27
AU572086B2 (en) 1988-05-05
JPH04217983A (ja) 1992-08-07
PL136332B1 (en) 1986-02-28
NO161740B (no) 1989-06-12
DE3266644D1 (en) 1985-11-07
NO821676L (no) 1982-11-22
BR8202931A (pt) 1983-05-03
PT74934B (en) 1984-05-08
US4355032A (en) 1982-10-19
CA1305141C (en) 1992-07-14
MY8700793A (en) 1987-12-31
RO84860B (ro) 1984-10-30
NO161740C (no) 1989-09-20
ES529384A0 (es) 1987-01-01
ES520849A0 (es) 1984-11-01
US4355032B2 (en) 1990-10-30
PL136004B1 (en) 1986-01-31
ES533821A0 (es) 1985-06-16
LU88334I2 (fr) 1994-09-09
DK504183A (da) 1983-11-03
ES8701496A1 (es) 1987-01-01
AU8389282A (en) 1982-11-25
DK227782A (da) 1982-11-22
DK149001B (da) 1985-12-16
PT74934A (en) 1982-06-01
PL136637B1 (en) 1986-03-31
EP0066208A1 (en) 1982-12-08
SG81687G (en) 1989-07-07
CS235042B2 (en) 1985-04-16
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
ES529383A0 (es) 1986-05-16
IE821210L (en) 1982-11-21
RO84860A (ro) 1984-09-29
DK504183D0 (da) 1983-11-03
NZ200691A (en) 1986-11-12
FI73682C (fi) 1987-11-09
DD213218A5 (de) 1984-09-05
AR244227A1 (es) 1993-10-29
ES8601204A1 (es) 1985-11-16
IL65836A (en) 1991-04-15
ES8507549A1 (es) 1985-09-16
HU188000B (en) 1986-03-28
CA1305140C (en) 1992-07-14
PL242100A1 (en) 1984-04-24
US4355032B1 (ja) 1983-06-14
FI73682B (fi) 1987-07-31
SU1176841A3 (ru) 1985-08-30
IL65836A0 (en) 1982-08-31
GR76459B (ja) 1984-08-10
PL236521A1 (en) 1984-01-02
ES512414A0 (es) 1984-05-01
CS235018B2 (en) 1985-04-16
ES524900A0 (es) 1985-11-16
KR830010112A (ko) 1983-12-26
ES8500276A1 (es) 1984-11-01
ES8606869A1 (es) 1986-05-16
ES8505681A1 (es) 1985-06-16
NO1994005I1 (no) 1994-07-29
ES524899A0 (es) 1985-09-16
PL136579B1 (en) 1986-02-28
CA1305139C (en) 1992-07-14
JPH046195B2 (ja) 1992-02-05
ES8404355A1 (es) 1984-05-01

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