CY1105725T1 - Ενισχυοντας την κυκλοφορουσα ημιπεριοδο - ζωης των με βαση - αντισωματα χιμαιρικων πρωτεϊνων - Google Patents

Ενισχυοντας την κυκλοφορουσα ημιπεριοδο - ζωης των με βαση - αντισωματα χιμαιρικων πρωτεϊνων

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Publication number
CY1105725T1
CY1105725T1 CY20061101528T CY061101528T CY1105725T1 CY 1105725 T1 CY1105725 T1 CY 1105725T1 CY 20061101528 T CY20061101528 T CY 20061101528T CY 061101528 T CY061101528 T CY 061101528T CY 1105725 T1 CY1105725 T1 CY 1105725T1
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CY
Cyprus
Prior art keywords
disclosed
life
circulating half
antibody
enhancing
Prior art date
Application number
CY20061101528T
Other languages
English (en)
Inventor
Stephen D. Gillies
Christa Burger
Kin Ming Lo
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CY1105725T1 publication Critical patent/CY1105725T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Αποκαλύπτονται και δημοσιοποιούνται συνθέσεις και μέθοδοι για την ενίσχυση της κυκλοφορούσας ημιπεριόδου-ζωής των με βάση αντισώματα χιμαιρικών πρωτεϊνών. Οι αποκαλυπτόμενες και δημοσιοποιούμενες μέθοδοι και συνθέσεις βασίζονται στην μετατροπή της ακολουθίας αμινοξέων της περιοχής συμβολής μεταξύ της χημικής οντότητας αντισώματος και της χημικής οντότητας της συντηχθείσας πρωτεΐνης σε μια με βάση αντισώματα χιμαιρική πρωτεΐνη. Μια με βάση αντισώματα χιμαιρική πρωτεΐνη με μια μετατραπείσα ακολουθία αμινοξέων στην περιοχή συμβολής έχει μια μεγαλύτερη κυκλοφορούσα ημιπερίοδο ζωής όταν χορηγείται σε ένα θηλαστικό. Οι αποκαλυπτόμενες και δημοσιοποιούμενες μέθοδοι και συνθέσεις είναι ειδικότερα δε χρήσιμες για την μείωση του μεγέθους των όγκων και της μετάστασης σε ένα θηλαστικό.
CY20061101528T 2000-02-11 2006-10-24 Ενισχυοντας την κυκλοφορουσα ημιπεριοδο - ζωης των με βαση - αντισωματα χιμαιρικων πρωτεϊνων CY1105725T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18176800P 2000-02-11 2000-02-11
PCT/US2001/004455 WO2001058957A2 (en) 2000-02-11 2001-02-09 Enhancing the circulating half-life of antibody-based fusion proteins

Publications (1)

Publication Number Publication Date
CY1105725T1 true CY1105725T1 (el) 2010-12-22

Family

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Family Applications (1)

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CY20061101528T CY1105725T1 (el) 2000-02-11 2006-10-24 Ενισχυοντας την κυκλοφορουσα ημιπεριοδο - ζωης των με βαση - αντισωματα χιμαιρικων πρωτεϊνων

Country Status (16)

Country Link
US (3) US7091321B2 (el)
EP (1) EP1252192B1 (el)
JP (2) JP5179689B2 (el)
CN (1) CN1406249B (el)
AT (1) ATE336514T1 (el)
AU (1) AU4314801A (el)
CA (1) CA2399832C (el)
CY (1) CY1105725T1 (el)
DE (1) DE60122286T2 (el)
DK (1) DK1252192T3 (el)
ES (1) ES2269366T3 (el)
HU (1) HUP0204475A2 (el)
MX (1) MXPA02007733A (el)
NO (1) NO20023774L (el)
PT (1) PT1252192E (el)
WO (1) WO2001058957A2 (el)

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JP5179689B2 (ja) 2013-04-10
DE60122286D1 (de) 2006-09-28
JP2003522200A (ja) 2003-07-22
EP1252192B1 (en) 2006-08-16
NO20023774D0 (no) 2002-08-09
PT1252192E (pt) 2007-01-31
US20090264627A1 (en) 2009-10-22
HUP0204475A2 (en) 2003-04-28
CA2399832C (en) 2011-09-20
WO2001058957A3 (en) 2002-05-02
JP2012176969A (ja) 2012-09-13
EP1252192A2 (en) 2002-10-30
CA2399832A1 (en) 2001-08-16
DE60122286T2 (de) 2007-08-02
ES2269366T3 (es) 2007-04-01
MXPA02007733A (es) 2004-09-10
US7507406B2 (en) 2009-03-24
ATE336514T1 (de) 2006-09-15
WO2001058957A2 (en) 2001-08-16
DK1252192T3 (da) 2006-11-20
NO20023774L (no) 2002-08-09
CN1406249A (zh) 2003-03-26
US7091321B2 (en) 2006-08-15
US20020147311A1 (en) 2002-10-10
CN1406249B (zh) 2010-06-16
US20060034836A1 (en) 2006-02-16
US7790415B2 (en) 2010-09-07
AU4314801A (en) 2001-08-20
JP5572665B2 (ja) 2014-08-13

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