MX371187B - Péptidos terapéuticos. - Google Patents
Péptidos terapéuticos.Info
- Publication number
- MX371187B MX371187B MX2016007063A MX2016007063A MX371187B MX 371187 B MX371187 B MX 371187B MX 2016007063 A MX2016007063 A MX 2016007063A MX 2016007063 A MX2016007063 A MX 2016007063A MX 371187 B MX371187 B MX 371187B
- Authority
- MX
- Mexico
- Prior art keywords
- therapeutic peptides
- peptides
- mica
- polypeptide
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención refiere a un anticuerpo o fragmento de anticuerpo que se une inmunoespecíficamente a secuencia A relacionada con polipéptido MHC clase I (MICA), caracterizado porque comprende una región variable de cadena pesada (VH) y una región variable de cadena ligera (VL), en donde la región VH comprende CDR1 de VH, CDR2 de VH y CDR3 de VH como se muestra en la secuencia de aminoácidos de VH de SEQ ID NO: 168; y en donde la región VL comprende CDR1 de VL, CDR2 de VL, y CDR3 de VL como se muestra en la secuencia de aminoácidos de VL de SEQ ID NO: 170.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361913198P | 2013-12-06 | 2013-12-06 | |
US201461953588P | 2014-03-14 | 2014-03-14 | |
PCT/US2014/068862 WO2015085210A1 (en) | 2013-12-06 | 2014-12-05 | Therapeutic peptides |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016007063A MX2016007063A (es) | 2016-09-06 |
MX371187B true MX371187B (es) | 2020-01-22 |
Family
ID=52293185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016007063A MX371187B (es) | 2013-12-06 | 2014-12-05 | Péptidos terapéuticos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US10106611B2 (es) |
EP (1) | EP3077504B1 (es) |
JP (1) | JP6705746B2 (es) |
KR (1) | KR20160090904A (es) |
CN (1) | CN106029694A (es) |
AU (1) | AU2014360273A1 (es) |
BR (1) | BR112016012358A2 (es) |
CA (1) | CA2932767A1 (es) |
EA (1) | EA201691078A1 (es) |
ES (1) | ES2755129T3 (es) |
IL (1) | IL245744A0 (es) |
MX (1) | MX371187B (es) |
WO (1) | WO2015085210A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2014532053A (ja) | 2011-09-30 | 2014-12-04 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 治療用ペプチド |
CN105142668B (zh) | 2013-03-15 | 2018-04-27 | 达纳-法伯癌症研究院公司 | 治疗性肽 |
WO2015003114A1 (en) | 2013-07-05 | 2015-01-08 | University Of Washington Through Its Center For Commercialization | Soluble mic neutralizing monoclonal antibody for treating cancer |
US10144778B2 (en) | 2014-03-12 | 2018-12-04 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
EP3925973A1 (en) | 2014-03-14 | 2021-12-22 | Dana-Farber Cancer Institute, Inc. | Vaccine compositions and methods for restoring nkg2d pathway function against cancers |
JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
EP3399989B1 (en) | 2015-12-16 | 2023-08-09 | Merck Sharp & Dohme LLC | Anti-lag3 antibodies and antigen-binding fragments |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
AU2017344411A1 (en) | 2016-10-19 | 2019-05-09 | Novelogics Biotechnology, Inc. | Antibodies to MICA and MICB proteins |
CN110267678A (zh) * | 2016-10-29 | 2019-09-20 | 霍夫曼-拉罗奇有限公司 | 抗mic抗体和使用方法 |
US10300089B2 (en) * | 2016-11-08 | 2019-05-28 | University Of Central Florida Research Foundation, Inc. | Methods for high scale therapeutic production of memory NK cells |
CN108299557A (zh) * | 2017-01-13 | 2018-07-20 | 杭州翰思生物医药有限公司 | 提高IgG类抗体对FcRn的结合亲和力并延长其血清半衰期的方法 |
US20200023071A1 (en) | 2017-02-06 | 2020-01-23 | Innate Pharma | Immunomodulatory antibody drug conjugates binding to a human mica polypeptide |
CN109475617B (zh) | 2017-02-22 | 2022-05-17 | 天境生物科技(杭州)有限公司 | 抗lag-3抗体及其应用 |
SG11201908396PA (en) | 2017-03-31 | 2019-10-30 | Bristol Myers Squibb Co | Methods of treating tumor |
CN109232738B (zh) * | 2017-07-11 | 2021-11-09 | 南京金斯瑞生物科技有限公司 | 一种抗人ox40单克隆抗体及其应用 |
US20200239577A1 (en) | 2017-10-15 | 2020-07-30 | Bristol-Myers Squibb Company | Methods of treating tumor |
EP3768715A1 (en) * | 2018-03-23 | 2021-01-27 | Bristol-Myers Squibb Company | Antibodies against mica and/or micb and uses thereof |
US20210032344A1 (en) | 2018-03-30 | 2021-02-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
WO2020035345A1 (en) | 2018-08-14 | 2020-02-20 | Innate Pharma | Treatment of colorectal cancer by a combination of an anti-mica antibody and an anti-nkg2a antibody |
EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
US20230296611A1 (en) | 2020-08-10 | 2023-09-21 | Innate Pharma | Cell surface mica and micb detection using antibodies |
CA3224182A1 (en) * | 2021-06-17 | 2022-12-22 | Fapon Biotech Inc. | Chimeric immunoglobulin |
CN113637077B (zh) * | 2021-10-14 | 2021-12-24 | 尚健单抗(北京)生物技术有限公司 | 一种抗mica的抗体及其应用 |
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-
2014
- 2014-12-05 JP JP2016536690A patent/JP6705746B2/ja active Active
- 2014-12-05 EA EA201691078A patent/EA201691078A1/ru unknown
- 2014-12-05 CN CN201480075001.0A patent/CN106029694A/zh active Pending
- 2014-12-05 US US15/100,060 patent/US10106611B2/en active Active
- 2014-12-05 CA CA2932767A patent/CA2932767A1/en not_active Abandoned
- 2014-12-05 EP EP14824621.8A patent/EP3077504B1/en active Active
- 2014-12-05 MX MX2016007063A patent/MX371187B/es active IP Right Grant
- 2014-12-05 WO PCT/US2014/068862 patent/WO2015085210A1/en active Application Filing
- 2014-12-05 KR KR1020167017672A patent/KR20160090904A/ko not_active Application Discontinuation
- 2014-12-05 BR BR112016012358A patent/BR112016012358A2/pt not_active Application Discontinuation
- 2014-12-05 AU AU2014360273A patent/AU2014360273A1/en not_active Abandoned
- 2014-12-05 ES ES14824621T patent/ES2755129T3/es active Active
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AU2014360273A1 (en) | 2016-06-02 |
MX2016007063A (es) | 2016-09-06 |
ES2755129T3 (es) | 2020-04-21 |
EP3077504B1 (en) | 2019-08-14 |
JP6705746B2 (ja) | 2020-06-03 |
BR112016012358A2 (pt) | 2017-09-26 |
EA201691078A1 (ru) | 2017-01-30 |
IL245744A0 (en) | 2016-07-31 |
CN106029694A (zh) | 2016-10-12 |
US10106611B2 (en) | 2018-10-23 |
KR20160090904A (ko) | 2016-08-01 |
US20170022275A1 (en) | 2017-01-26 |
WO2015085210A1 (en) | 2015-06-11 |
EP3077504A1 (en) | 2016-10-12 |
CA2932767A1 (en) | 2015-06-11 |
JP2017501692A (ja) | 2017-01-19 |
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