MX371187B - Péptidos terapéuticos. - Google Patents

Péptidos terapéuticos.

Info

Publication number
MX371187B
MX371187B MX2016007063A MX2016007063A MX371187B MX 371187 B MX371187 B MX 371187B MX 2016007063 A MX2016007063 A MX 2016007063A MX 2016007063 A MX2016007063 A MX 2016007063A MX 371187 B MX371187 B MX 371187B
Authority
MX
Mexico
Prior art keywords
therapeutic peptides
peptides
mica
polypeptide
compositions
Prior art date
Application number
MX2016007063A
Other languages
English (en)
Other versions
MX2016007063A (es
Inventor
W Wucherpfennig Kai
Franz Bettina
Stephen Hodi F
Harvey Christopher
Dranoff Glenn
F May Kenneth Jr
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of MX2016007063A publication Critical patent/MX2016007063A/es
Publication of MX371187B publication Critical patent/MX371187B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención refiere a un anticuerpo o fragmento de anticuerpo que se une inmunoespecíficamente a secuencia A relacionada con polipéptido MHC clase I (MICA), caracterizado porque comprende una región variable de cadena pesada (VH) y una región variable de cadena ligera (VL), en donde la región VH comprende CDR1 de VH, CDR2 de VH y CDR3 de VH como se muestra en la secuencia de aminoácidos de VH de SEQ ID NO: 168; y en donde la región VL comprende CDR1 de VL, CDR2 de VL, y CDR3 de VL como se muestra en la secuencia de aminoácidos de VL de SEQ ID NO: 170.
MX2016007063A 2013-12-06 2014-12-05 Péptidos terapéuticos. MX371187B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361913198P 2013-12-06 2013-12-06
US201461953588P 2014-03-14 2014-03-14
PCT/US2014/068862 WO2015085210A1 (en) 2013-12-06 2014-12-05 Therapeutic peptides

Publications (2)

Publication Number Publication Date
MX2016007063A MX2016007063A (es) 2016-09-06
MX371187B true MX371187B (es) 2020-01-22

Family

ID=52293185

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016007063A MX371187B (es) 2013-12-06 2014-12-05 Péptidos terapéuticos.

Country Status (13)

Country Link
US (1) US10106611B2 (es)
EP (1) EP3077504B1 (es)
JP (1) JP6705746B2 (es)
KR (1) KR20160090904A (es)
CN (1) CN106029694A (es)
AU (1) AU2014360273A1 (es)
BR (1) BR112016012358A2 (es)
CA (1) CA2932767A1 (es)
EA (1) EA201691078A1 (es)
ES (1) ES2755129T3 (es)
IL (1) IL245744A0 (es)
MX (1) MX371187B (es)
WO (1) WO2015085210A1 (es)

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JP2022553643A (ja) * 2019-10-09 2022-12-26 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 細胞傷害性ｔ細胞耐性腫瘍を治療するための組成物および方法
JP7821779B2 (ja) 2020-08-10 2026-02-27 イナート・ファルマ・ソシエテ・アノニム 抗体を使用した細胞表面ｍｉｃａ及びｍｉｃｂの検出
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CA2932767A1 (en) 2015-06-11
WO2015085210A1 (en) 2015-06-11
AU2014360273A1 (en) 2016-06-02
EA201691078A1 (ru) 2017-01-30
BR112016012358A2 (pt) 2017-09-26
JP2017501692A (ja) 2017-01-19
KR20160090904A (ko) 2016-08-01
JP6705746B2 (ja) 2020-06-03
EP3077504A1 (en) 2016-10-12
US20170022275A1 (en) 2017-01-26
CN106029694A (zh) 2016-10-12
MX2016007063A (es) 2016-09-06
ES2755129T3 (es) 2020-04-21

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