ES2054753T3 - Conjugados de citoquinas con inmunoglobulinas. - Google Patents
Conjugados de citoquinas con inmunoglobulinas.Info
- Publication number
- ES2054753T3 ES2054753T3 ES88114130T ES88114130T ES2054753T3 ES 2054753 T3 ES2054753 T3 ES 2054753T3 ES 88114130 T ES88114130 T ES 88114130T ES 88114130 T ES88114130 T ES 88114130T ES 2054753 T3 ES2054753 T3 ES 2054753T3
- Authority
- ES
- Spain
- Prior art keywords
- conjugates
- immunoglobulins
- cytokines
- cytokine
- tumours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G99/00—Subject matter not provided for in other groups of this subclass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Abstract
LA PRESENTE PATENTE AFECTA A NUEVOS CONJUGADOS COMPUESTOS POR UNA CITOCINA, P.E. INTERFERON ALFA, Y POR INMUNOGLOBULINA HUMANA, SI SE DESEA UNIDOS SOBRE UN FORMADOR DE PUENTES ORGANICO; PROCESO PARA LA PRODUCCION DE ESTOS CONJUGADOS, PREPARACIONES FARMACEUTICAS Y EL USO DE ESTOS CONJUGADOS PARA EL TRATAMIENTO DE INFECCIONES VIRALES Y DE TUMORES. FRENTE A LA CITOCINA LIBRE MUESTRAN ESTOS CONJUGADOS UN MAYOR TIEMPO DE PERMANENCIA EN PLASMA Y TEJIDOS, CON LO QUE MEJORAN EL EFECTO TERAPEUTICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH335787 | 1987-09-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2054753T3 true ES2054753T3 (es) | 1994-08-16 |
Family
ID=4254228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88114130T Expired - Lifetime ES2054753T3 (es) | 1987-09-02 | 1988-08-30 | Conjugados de citoquinas con inmunoglobulinas. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0305967B1 (es) |
JP (1) | JPS6490200A (es) |
KR (1) | KR890005137A (es) |
AT (1) | ATE88900T1 (es) |
AU (1) | AU627694B2 (es) |
DE (1) | DE3880766D1 (es) |
DK (1) | DK486588A (es) |
ES (1) | ES2054753T3 (es) |
FI (1) | FI884013A (es) |
IL (1) | IL87621A0 (es) |
NO (1) | NO883896L (es) |
NZ (1) | NZ226005A (es) |
PH (1) | PH26813A (es) |
PT (1) | PT88385B (es) |
ZA (1) | ZA886471B (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3818055A1 (de) * | 1988-05-27 | 1989-11-30 | Biotest Pharma Gmbh | Kombination aus humanen immunglobulinen und interleukin-2 zur bekaempfung von infektionskrankheiten |
GB8820378D0 (en) * | 1988-08-26 | 1988-09-28 | Offord R E | Chemical compounds |
GB8820377D0 (en) * | 1988-08-26 | 1988-09-28 | Offord R E | Chemical compounds |
KR900005995A (ko) * | 1988-10-31 | 1990-05-07 | 우메모또 요시마사 | 변형 인터류킨-2 및 그의 제조방법 |
DE3839332A1 (de) * | 1988-11-22 | 1990-05-23 | Bayer Ag | Verfahren zur herstellung von substituierten 2-chlorpyridinen |
IE63847B1 (en) * | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
US5527527A (en) * | 1989-09-07 | 1996-06-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
US5977307A (en) * | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
US5182107A (en) * | 1989-09-07 | 1993-01-26 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
US5154924A (en) * | 1989-09-07 | 1992-10-13 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
US5314995A (en) * | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
US5349053A (en) * | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
US5478804A (en) * | 1990-09-19 | 1995-12-26 | The Salk Institute For Biological Studies | Treatment of tumorigenic pathophysiological conditions with FGF-cytoxic conjugates |
EP0565620B1 (en) * | 1991-01-03 | 1995-09-20 | The Salk Institute For Biological Studies | Mitotoxin for treatment of vascular injury |
ATE141515T1 (de) * | 1991-02-04 | 1996-09-15 | Univ Saskatchewan | Arzneistoffabgabe aus vp6-kapseln |
PT100090A (pt) * | 1991-02-04 | 1993-07-30 | Univ Saskatchewan | Metodo de preparacao de uma composicao capz de libertar um agente biologicamente activo para um alvo, e de encapsulacao do referido agente em esferas da proteina vp6 |
JP3105629B2 (ja) * | 1991-04-23 | 2000-11-06 | サングスタット メディカル コーポレイション | 特異的結合ペアのメンバーの細胞活性調節接合体 |
EP0533006A1 (en) * | 1991-09-18 | 1993-03-24 | F.Hoffmann-La Roche & Co. Aktiengesellschaft | Chimaeric interleukin 5-receptor/immunoglobulin polypeptides |
US7754211B2 (en) | 1992-04-10 | 2010-07-13 | Research Development Foundation | Immunotoxins directed against c-erbB-2(HER-2/neu) related surface antigens |
US6030613A (en) * | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
US6086875A (en) * | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
US6485726B1 (en) | 1995-01-17 | 2002-11-26 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
US6015555A (en) * | 1995-05-19 | 2000-01-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
AU2610097A (en) * | 1996-04-10 | 1997-10-29 | Sangstat Medical Corporation | Cytomodulating conjugates of members of specific binding pairs |
IT1289608B1 (it) * | 1997-02-05 | 1998-10-15 | Angelini Ricerche Spa | Composizione per uso terapeutico o diagnostico somministrabile per via intranasale,sublinguale o vaginale |
CA2312188C (en) | 1997-12-08 | 2010-06-29 | Lexigen Pharmaceuticals Corp. | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US6617135B1 (en) | 1999-08-09 | 2003-09-09 | Emd Lexigen Research Center Corp. | Multiple cytokine protein complexes |
DK1252192T3 (da) | 2000-02-11 | 2006-11-20 | Merck Patent Gmbh | Forbedring af antistofbaserede fusionsproteiners serumhalveringstid |
JP5059271B2 (ja) | 2000-03-31 | 2012-10-24 | パーデュー・リサーチ・ファウンデイション | リガンド免疫原複合体を用いる処置方法 |
ZA200305980B (en) | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
MXPA03008031A (es) | 2001-03-07 | 2003-12-04 | Merck Patent Gmbh | Tecnologia de expresion para proteinas que contienen porcion de anticuerpo isotipo hibrida. |
WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
DK1383785T3 (da) | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Rekombinant tumorspecifikt antistof og anvendelse deraf |
AU2002327310B2 (en) | 2001-07-17 | 2006-09-28 | Research Development Foundation | Therapeutic agents comprising pro-apoptotic proteins |
AU2002357784B2 (en) | 2001-12-04 | 2008-07-31 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
JP4494977B2 (ja) | 2002-12-17 | 2010-06-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Gd2に結合するマウス14.18抗体のヒト化抗体(h14.18)およびそのil−2融合タンパク質 |
BRPI0418286A (pt) | 2003-12-30 | 2007-05-02 | Merck Patent Gmbh | proteìnas de fusão de il-7 |
EP1706428B1 (en) | 2004-01-22 | 2009-09-23 | MERCK PATENT GmbH | Anti-cancer antibodies with reduced complement fixation |
US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
ATE555125T1 (de) | 2005-12-30 | 2012-05-15 | Merck Patent Gmbh | Interleukin-12p40-varianten mit verbesserter stabilität |
JP2009521912A (ja) | 2005-12-30 | 2009-06-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 低減された免疫原性を有する抗cd19抗体 |
AU2010238858A1 (en) | 2009-04-22 | 2011-12-08 | Merck Patent Gmbh | Antibody fusion proteins with modified FcRn binding sites |
JP5879713B2 (ja) * | 2010-12-09 | 2016-03-08 | ソニー株式会社 | 画像処理装置、および画像処理方法、並びにプログラム |
EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
CN109395064A (zh) | 2013-04-19 | 2019-03-01 | 赛腾制药 | 降低的血管渗漏综合征的细胞因子衍生治疗 |
EP2915569A1 (en) | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1564666A (en) * | 1978-05-31 | 1980-04-10 | Ng Mun Hon | Heterocomplexes of interferon with immunoglobulin and pharmaceutical compositions thereof |
-
1988
- 1988-08-30 EP EP88114130A patent/EP0305967B1/de not_active Expired - Lifetime
- 1988-08-30 AT AT88114130T patent/ATE88900T1/de not_active IP Right Cessation
- 1988-08-30 DE DE8888114130T patent/DE3880766D1/de not_active Expired - Fee Related
- 1988-08-30 PH PH37474A patent/PH26813A/en unknown
- 1988-08-30 ES ES88114130T patent/ES2054753T3/es not_active Expired - Lifetime
- 1988-08-31 FI FI884013A patent/FI884013A/fi not_active IP Right Cessation
- 1988-08-31 ZA ZA886471A patent/ZA886471B/xx unknown
- 1988-08-31 IL IL87621A patent/IL87621A0/xx unknown
- 1988-08-31 NZ NZ226005A patent/NZ226005A/xx unknown
- 1988-08-31 PT PT88385A patent/PT88385B/pt not_active IP Right Cessation
- 1988-09-01 AU AU21725/88A patent/AU627694B2/en not_active Ceased
- 1988-09-01 KR KR1019880011274A patent/KR890005137A/ko not_active Application Discontinuation
- 1988-09-01 DK DK486588A patent/DK486588A/da not_active Application Discontinuation
- 1988-09-01 NO NO88883896A patent/NO883896L/no unknown
- 1988-09-01 JP JP63216441A patent/JPS6490200A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU627694B2 (en) | 1992-09-03 |
NO883896D0 (no) | 1988-09-01 |
NZ226005A (en) | 1990-10-26 |
PH26813A (en) | 1992-11-05 |
ATE88900T1 (de) | 1993-05-15 |
DK486588D0 (da) | 1988-09-01 |
FI884013A (fi) | 1989-03-03 |
NO883896L (no) | 1989-03-03 |
KR890005137A (ko) | 1989-05-13 |
EP0305967A2 (de) | 1989-03-08 |
DE3880766D1 (de) | 1993-06-09 |
ZA886471B (en) | 1989-04-26 |
JPS6490200A (en) | 1989-04-06 |
AU2172588A (en) | 1989-03-23 |
EP0305967B1 (de) | 1993-05-05 |
EP0305967A3 (en) | 1990-01-31 |
IL87621A0 (en) | 1989-01-31 |
PT88385B (pt) | 1992-10-30 |
DK486588A (da) | 1989-03-03 |
FI884013A0 (fi) | 1988-08-31 |
PT88385A (pt) | 1989-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2054753T3 (es) | Conjugados de citoquinas con inmunoglobulinas. | |
DE59101397D1 (de) | O-glycosyliertes ifn-alpha. | |
ATE72991T1 (de) | Nasale verabreichung von arzneimitteln. | |
ATE358176T1 (de) | Menschliche dnase | |
AU586860B2 (en) | Therapeutical application of phosphonylmethoxyalkyl adenines | |
NO940219L (no) | Rekombinante antistoffer for human terapi | |
GEP19981482B (en) | Use of 1,3 - Oxatiolan Nucleozides Analoges for Treatment of Hepatitis B | |
NO931413L (no) | Fremgangsmaater og preparater for behandling av celleproliferasjonssykdommer | |
DE68912155T2 (de) | Antivirales Kombinationspräparat. | |
NO891006D0 (no) | Terapeutisk aktivt polypeptid og fremgangsmaate for dets fremstilling. | |
ATE67783T1 (de) | Homogene rekombinante immun-interferon-fragmente und diese enthaltende pharmazeutische zusammensetzungen. | |
ES2115582T3 (es) | Preparacion y aplicaciones de interferon-gamma. | |
ES2037807T3 (es) | Medicamentos que contienen en combinacion interferon y 1-desoxi-piperidinosas, procedimiento para su fabricacion y su aplicacion. | |
ES2061496T3 (es) | Tratamiento intralesional del carcinoma de celulas basales con alfa-interferon humano recombinante. | |
ES2039276T3 (es) | Uso de una combinacion de interferon gamma e interferon alfa para la preparacion de un medicamento para el tratamiento de ciertas leucemias. | |
ATE92333T1 (de) | Arzneimittel zur intralesionsbehandlung von schuppenartigem zellkarzinomen mit rekombinantem human-alpha-interferon. | |
DK0427633T3 (da) | Anvendelse af et polypeptid med gammainterferonaktivitet til fremstilling af farmaceutiske præparater beregnet til behandling af primitiv pleuracancer | |
IT9086214A1 (it) | Cura o guarigione del cancro o maurosalute |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 305967 Country of ref document: ES |