CN1867679A - 用于胃癌检测的标记物 - Google Patents
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Abstract
肿瘤的早期检测是患有肿瘤(包括胃肿瘤)的患者存活的主要决定因素。GTM基因家族成员在胃肿瘤组织和其它肿瘤组织中过表达,因此其可以用作胃癌和其它类型癌症的标记物。GTM蛋白质可以从癌细胞中释放出来,并在血清和/或其它体液中达到足够高的浓度从而得以检测它们。因此,用于GTM检测和定量的方法和检测试剂盒能够提供胃癌诊断的有价值的工具。
Description
相关申请
依据美国法典第35卷第119条(35U.S.C.119),本申请要求美国临时专利申请序列号60/487,906的优先权,美国临时专利申请序列号60/487,906为2003年7月17日提交的,标题为“用于胃癌检测的标记物”,发明者为Parry John Guilford。上述申请在本文完全整合作为参考。
发明领域
本发明涉及癌症的检测。具体而言,本发明涉及用于癌症检测的遗传标记物和/或蛋白质标记物的用途,并且更加具体而言涉及到遗传标记物和/或蛋白质标记物用于胃癌检测的用途。
发明背景
癌症的早期检测和治疗能显著提高癌症患者的存活。以胃癌为例,诊断为疾病早期的患者5年存活率为90%,而诊断为疾病晚期的患者5年存活率约为10%。然而,绝大多数胃癌患者通常处于疾病晚期。因此,开发胃癌早期诊断方法能够改善患者的预后。
在包括体液如血液、尿液、腹膜灌洗液和粪便提取物在内的生物标本中的特异性癌症相关标记物的鉴定能提供有价值的癌症早期诊断方法,以便早期治疗并改善预后。特异性癌症标记物还能提供用于监测疾病进展的方法,从而能跟踪外科手术、放射治疗和化学治疗的功效。然而,对于许多主要癌症,可利用的标记物缺乏足够的敏感性和特异性。例如,用于胃癌的最常用标记物ca19-9、ca72-4和癌胚抗原(CEA)仅检测到大约15-50%的任何阶段的胃肿瘤,对于疾病早期的检测则降至大约2-11%。因此,出现假阴性检测的频率非常高,这导致患者和健康护理工作者认为不存在疾病,而事实上,患者可能患有严重的需要立即注意的癌症。而且,使用这些标记物可能对高达1/3的患有良性胃疾病个体给出假阳性信号。
发明简述
因此,迫切需要更好的检测癌症存在的方法。本发明方面提供了能够检测早期癌症和降低假阳性和假阴性测试结果频率的方法、成分和装置。
在某些实施方案中,可以使用分子分析来鉴定与非恶性胃组织相比在胃肿瘤组织中过表达的基因。此分析包括微阵列和定量聚合酶链反应(qPCR)方法。癌基因和由那些基因编码的蛋白质在本文中称作胃肿瘤标记物(GTM)。需要理解的是术语GTM并不要求标记物仅仅对于胃肿瘤是特异的。而是应当解释为:GTM可以在包括恶性或非恶性肿瘤在内的其他类型肿瘤中表达增加,其中所述肿瘤除此之外包括胃癌、膀胱癌、结肠直肠癌、胰腺癌、卵巢癌、皮肤癌(例如:黑素瘤)、肝癌、食道癌、子宫内膜癌和脑癌。无论如何应当这样理解,即术语GTM不包括在先技术标记物ca19-9、ca72-4和CEA。一些GTM的过表达足以高度可靠地诊断胃癌,而且在其它情况下,两种或多种GTM的过表达能提供胃癌的可靠诊断。
在某些实施方案中,可以用微阵列方法来检测一种或多种癌相关基因的过表达模式。
在其它实施方案中,可以用定量聚合酶链反应(qPCR)来鉴定肿瘤或其它生物样品中过表达标记物的存在。
在本文公开的一些GTM检测的实施方案中,GTM在肿瘤细胞内以高度选择方式过表达而在非肿瘤细胞即使表达也是很少,从而能够只检测一种过表达的GTM来对癌症进行敏感和精确检测。在其它实施方案中,可以在样品中检测两种、三种或更多GTM的过表达并从而能提供更大的诊断确定性。
所选择基因编码的蛋白质能够被细胞分泌出来或从细胞中穿透出来。这些蛋白质可以单独或彼此联合用作诊断胃癌的血清或体液标记物或者作为监测所确定疾病进展的标记物。可以使用本领域已知的方法开展蛋白质标记物的检测,并且所述方法包括单克隆抗体、多克隆抗血清等的使用。
附图简述
关于其特定实施方案和图在本发明中进行了描述,其中:
图1描述了本发明的胃癌标记物及其寡核苷酸序列列表。
图2描述了用微阵列方法进行研究获得的结果列表。
图3描述了用定量PCR进行研究获得的结果列表。
图4a-4d描述了用微阵列方法和qPCR方法获得的倍数的log2数值结果之间的关系,其中对于四种胃癌标记物数据集中于中间的正常值。灰色方块对应非恶性肿瘤(“正常”)样品,而黑色三角对应肿瘤样品。图4a:ASPN。图4b:SPP1。图4c:SPARC。图4d:MMP12。
图5a-5w描述了显示从定量PCR研究获得的多种肿瘤标志物的相对频率对变化倍数的log2数值的柱状图。图5a:ASPN;图5b:CST1、2和4;图5c:CSPG2;图5d:IGFBP7;图5e:INHBA;图5f:LOXL2;图5g:LUM;图5h:SFRP4;图5i:SPARC;图5j:SPP1;图5k:THBS2;图5l:TIMP1;图5m:adlican;图5n:PRS11;图5o:ASAH1;图5p:SFRP2;图5q:GGH;图5r:MMP12;图5s:KLK10;图5t:LEPRE1;图5u:TG;图5v:EFEMP2和图5w:TGFBI。
图6是显示表达高于中间正常表达的第95百分位数的肿瘤标记物数量的柱状图。结果以qPCR数据为基础并分别显示了每一份肿瘤样品的结果。
图7a-7c描述了与肿瘤标记物CEA基因表达相比,在单个肿瘤样品和非恶性肿瘤样品中标记物的相对的log2表达图。CEA是当前最常用的用于监测胃癌进展的血清标记物。
图8显示的是图3的补充列表。图8总结了用qPCR检测候选肿瘤标记物的表达水平,但是使用的是配对数据(即肿瘤(“T”)和非恶性肿瘤(“N”)样品来自同一个体)从而提供T:N比。图8还包括了图3中未包括的其它标记物,即MMP2,CGR11,TGFB1,PCSK5,SERPINB5,SERPINH1。为了比较,也显示了已经建立的血清标记物基因CEACAM5(CEA)的表达水平。在29个标记物中有27个具有高于或等于CEA的T:N差异中值。此外,与CEA相比,全部29个标记物在配对样品中具有较高的百分比,其中在肿瘤样品中标记物的表达超过在正常样品中的表达。CST1,2,44、ASPN和SFRP4三种标记物在配对的肿瘤样品和正常样品之间的表达显示出100%的差异。本文显示了这三种标记物的基因序列以及用来检测它们的引物和探针位置。
图9a-9d描述了29种胃癌标记物在40位患者的配对样品中的单个的及中值的T:N变化倍数数据。
图10a-10ad描述了CEA和本发明中其它GTM表达在肿瘤分期和变化倍数的log2数值间的关系图。图10a:adlican;图10b:ASPN;图10c:CSPG2;图10d:CST1,2,4;图10e:EFEMP2;图10f:GGF;图10g:INHBA;图10h:IGFBP7;图10i:KLK10;图10j:LEPRE1;图10k:LUM;图10l:LOXL2;图10m:MMP12;图10n;TIMP1;图10o:ASAH1;图10p:SPP1;图10q:SFRP2;图10r:SFRP4;图10s:SPARC;图10t:PRSS11;图10u:THBS2:图10v:TG;图10w:TGFBI;图10x:CGR11;图10y:SERPINH1;图10z:MMP2;图10aa:PCSK5;图10ab:SERPINB5;图10ac:TGFB1和图10ad:CEA(CEACAM5)。
图11a-11ad描述了本发明的29种GTM和CEA表达在肿瘤类型(扩散型(D)和肠型(I))和变化倍数的log2数值间的关系图。图11a:adlican;图11b:ASPN;图11c:CSPG2;图11d:CST1,2,4;图11e:EFEMP2;图11f:GGH;图11g:INHBA;图11h:IGFBP7;图11i:KLK10;图11j:LEPRE1:图11k:LUM;图11l:LOXL2;图11m:MMP12;图11n:TIMP1;图11o:ASAH1;图11p:SPP1;图11q:SFRP2;图11r:SFRP4:图11s;SPARC;图11t:PRSS11:图11u:THBS2;图11v:TG;图11w:TGFBI;图11x:CGR11;图11y:SERPINH1;图11z:MMP2;图11aa:PCSK5;图11ab:SERPINB5;图11ac:TGFB1和图11ad:CEA(CEACAM5)。
图12描述了显示三种标记物SERPINH1、CST1,2,4和INHBA在一系列胃肿瘤样品和非恶性肿瘤胃样品中表达的三维图。
图13描述了显示多重标记物对精确区分肿瘤组织和非恶性肿瘤组织能力的影响的表。此表来自qPCR数据的正态分布。
图14是来源于肿瘤和非肿瘤组织的4种肿瘤标记物的Western印迹。
图15是胃癌组织和血清中肿瘤标志物SPARC的Western印迹。
图16是胃细胞系AGS上清中的半胱氨酸蛋白酶抑制剂SN的免疫印迹。
发明详述
定义
在详细描述本发明的实施方案之前,提供本文使用的一些术语的定义是有用的。
术语“GTM”或“胃肿瘤标记物”或“GTM家族成员”指与胃癌有关的基因、基因片段、RNA、RNA片段、蛋白质或相关蛋白质片段或者其它鉴别分子,其中不包括在先技术已知的与胃癌相关的分子ca19-9、ca72-4和CEA。下文包括了GTM实例。
述语“标记物”指在数量和质量上与生物现象的存在相关的分子。“标记物”的实例为GTM,然而,“标记物”还包括与不良状况形成机制直接相关或者间接相关的代谢产物、副产物。
术语“qPCR”指定量聚合酶链式反应。
术语“表达”包括mRNA从基因或基因部分的产生,并且包括由RNA或基因或基因部分所编码的蛋白质的产生,还包括与表达相关的检测物质的出现。例如,结合配体(如抗体)与基因或其它寡核苷酸、蛋白质或蛋白质片段的结合以及结合配体的显色都包括在术语“表达”的范围内。因此,在免疫印迹如Western印迹上斑点密度的增加也处于以生物学分子为基础的术语“表达”的范围内。
术语“CPN2”指人羧肽酶N多肽2(83kDa的链)和羧肽酶N。
术语“HAPLN4”指人透明质酸糖蛋白连接蛋白4。
术语“MMP12”指人基质金属蛋白酶12。
术语“INHBA”指人抑制素βA(还包括激活蛋白A、激活蛋白AB或α多肽)。
术语“IGFBP7”指人胰岛素样生长因子7。
术语“GGH”指人γ谷氨酰水解酶(也称作结合酶、叶酰聚γ谷氨酰水解酶)。
术语“LEPRE1”指人富含亮氨酸脯氨酸的蛋白多糖(也称作leprecan1)。
术语“CST4”指人半胱氨酸蛋白酶抑制剂S。
术语“SFRP4”指人分泌型frizzled相关蛋白4。
术语“ASPN”指人asporin(也称作1类LRR)。
术语“CGREF1”或“CGR11”指具有EF手型结构域1的人细胞生长调节因子。
除非另外说明,术语“KLK”指人激肽释放酶10变体1、或者人激肽释放酶10变体2、或者两者。
术语“TIMP1”指人金属蛋白酶组织抑制剂1(也称作促红细胞活性剂(erythroid potentiating activity)或胶原酶抑制剂)。
术语“SPARC”指富含半胱氨酸的人分泌型酸性蛋白质(也称作骨粘连蛋白)。
术语“TGFBI”指68kDa的人转化生长因子β诱导蛋白(transforminggrowth factor,beta-induced,68kDa)。
术语“EFEMP2”指包含EGF的纤蛋白样细胞外基质蛋白质2。
术语“LUM”指人光亮蛋白聚糖。
术语“SNN”指人stannin。
术语“SPP1”指人分泌型磷蛋白1(也称作骨桥蛋白或骨唾液酸蛋白I或早期T-淋巴细胞活化剂1)。
术语“CSPG2”指人硫酸软骨素蛋白聚糖2(也称作多功能蛋白聚糖)。
术语“ASAH1”指人N-酰基鞘氨醇酰胺水解酶变体1,或者N-酰基鞘氨醇酰胺水解酶变体2,或者N-酰基鞘氨醇酰胺水解酶变体1和2(也称作酸性神经酰胺酶1变体1和2)。
术语“PRSS11”指人丝氨酸蛋白酶11(也称作IGF结合丝氨酸蛋白酶)。
术语“SFRP2”指人分泌型frizzled相关蛋白2。
术语“PLA2G12B”指人XIIB组磷脂酶A2。
术语“SPON2”指人细胞外基质蛋白质spondin 2。
术语“OLFM1”指人嗅介蛋白1。
术语“TSRC1”指人包含重复的血小板反应蛋白1(thrombospondinrepeat containing 1)。
术语“THBS2”指人血小板反应蛋白2。
术语“adlican”指DKFZp564I1922。
术语“CST2”指人半胱氨酸蛋白酶抑制剂SA。
术语“CST1”指人半胱氨酸蛋白酶抑制剂SN。
术语“LOXL2”指人赖氨酰氧化酶样酶2。
术语“TG”指人甲状腺球蛋白。
术语“TGFB1”指人转化生长因子,β1。
术语“SERPINH1”指人丝氨酸或半胱氨酸蛋白酶抑制剂进化枝H(也称作热休克蛋白47成员1或胶原结合蛋白1)。
术语“SERPINB5”指人丝氨酸或半胱氨酸蛋白酶抑制剂进化枝B(也称作卵清蛋白成员5)。
术语“CEACAMS”或“CEA”指人癌胚抗原相关细胞黏附分子5。
术语“MMP2”指人基质金属蛋白酶2(也称作明胶酶A或72kDa明胶酶或72kDa IV型胶原酶)。
术语“PCSK5”指人前蛋白转化酶枯草杆菌蛋白酶/kexin类型5(proprotein convertase subtilisin/kexin type 5)。
应当理解,上述术语可以指蛋白质、DNA序列和/或RNA序列。还应当理解,上述术语还可以指具有与本文所述相同序列的非人类蛋白质、DNA和/或RNA。
本发明实施方案详述
本发明提供了在检测胃癌方面比在先技术的标记物可靠性更高的用于检测和评价肿瘤(包括胃癌)的标记物。术语“可靠性”包括不存在假阳性和/或假阴性。因此,标记物的可靠性越高,与使用此标记物所作出的诊断相关的假阳性和/或假阴性就越少。所以,在某些实施方案中,提供了允许胃癌检测可靠性比为50%左右的先技术标记物可靠性更高的标记物。在其它实施方案中,提供了可靠性大于70%左右的标记物;在其它实施方案中,提供了可靠性大于73%左右的标记物;还是在其它实施方案中,提供了可靠性大于80%左右的标记物;在更进一步的实施方案中,提供了可靠性大于90%左右的标记物;还是在其它实施方案中,提供了可靠性大于95%左右的标记物;在更进一步的实施方案中,提供了可靠性大于98%左右的标记物并且在某些实施方案中,提供了可靠性为大约100%的标记物。
因此,我们已经意外发现了许多其存在与胃肿瘤相关的基因和蛋白质。因此,对基因产物(例如寡核苷酸诸如mRNA)以及从该寡核苷酸翻译而来的蛋白质和肽的检测能用来诊断肿瘤,如胃肿瘤。对来自胃肿瘤患者的肿瘤组织和同一受试者非恶性肿瘤组织的样品进行阵列分析,意外地发现在很多胃肿瘤中某些基因过表达的特定模式与疾病相关。
还可以使用抗癌标记物的抗体检测癌标记物。
通过分析多个癌标记物的存在和表达量从而能提高诊断敏感性同时降低假阳性和/或假阴性结果的频率。
癌症检测的一般方法
以下方法是使用GTM家族成员检测包括胃癌在内的癌症的非限定性方法。
·使用对GTM基因产物具有选择性的寡核苷酸探针的微阵列方法。
·使用标记物特异性引物和探针对肿瘤样品和正常样品进行实时定量PCR(qPCR)。
·酶联免疫吸附测定法(ELISA)。
·使用抗标记物的抗体对胃肿瘤和淋巴结转移进行免疫组织化学分析。
·使用抗标记物的抗体对其它肿瘤进行免疫组织化学分析,其中所述的其它肿瘤包括但不限于结肠直肠癌、胰腺癌、卵巢癌、黑素瘤、肝癌、食道癌、膀胱癌、子宫内膜癌和脑癌。
·对胃癌患者手术切除肿瘤之前和之后留取血清中的标记物家族成员进行免疫检测。
·对健康个体和患有非恶性肿瘤疾病(例如胃炎、溃疡、胃上皮化生和发育异常)个体血清中的标记物家族成员进行免疫检测。
·对其它癌症患者中的标记物家族成员进行免疫检测,其中所述的其它癌症包括但不限于结肠直肠癌、胰腺癌、卵巢癌、黑素瘤、肝癌、食道癌、膀胱癌、子宫内膜癌和脑癌。
·对体液中的标记物进行检测,其中所述的体液包括血清、淋巴液、腹膜液、脑脊液、滑液等。
·对胃癌患者胃液、腹膜灌洗液、尿液和粪便中的标记物家族成员进行免疫检测。使用阵列方法和/或qPCR。
·使用计算机对阵列数据或qPCR数据进行分析。收集原始数据并通过比较胃肿瘤基因表达水平和同一基因在非肿瘤组织中的表达水平进行变化倍数分析。提供用于断定表达增加的阈值(例如,1.5倍增加、2倍增加,并且在备选的实施方案中为3倍增加、4倍增加或5倍增加)。应该意识到,用于断定已发生表达增加的其它阈值可以在不脱离本发明的范围内选择。对肿瘤基因表达的进一步分析包括将呈现出表达增加的那些基因与已知胃肿瘤表达谱相匹配以便诊断肿瘤。
在某些方面,本发明提供了检测癌症的方法,其包括:
(a)准备生物学样品;和
(b)检测GTM家族成员在所述样品中的过表达。
在其它方面,本发明包括检测GTM mRNA过表达的步骤。
在其他方面,本发明包括检测GTM蛋白质过表达的步骤。
在更进一步的方面,本发明包括检测GTM肽过表达的步骤。
在仍然进一步的方面,本发明包括检测GTM的装置,其包括:
其上具有GTM捕获试剂的基质;和
与所述基质关联的检测器,所述检测器能够检测与所述捕获试剂相关的GTM,其中捕获试剂包括寡核苷酸或抗体。
另外的方面包括用于检测癌症的试剂盒,其包含:基质;
GTM捕获试剂,其包含一种或更多GTM特异性寡核苷酸和GTM特异性抗体;和
使用说明书。
本发明更进一步的方面包括使用qPCR检测GTM的方法,其包括:
对所述GTM特异的正向引物;
对所述GTM特异的反向引物;
PCR试剂;
反应小管;和使用说明书。
本发明的另外方面包括检测GTM蛋白质或肽存在的试剂盒,其包含:
具有针对所述GTM蛋白质或肽的捕获试剂的基质;
对所述GTM蛋白质或肽特异的抗体;
能够对针对所述GTM蛋白质或肽的结合抗体进行标记的试剂;
和
使用说明书。
本发明的另外方面包括生产单克隆抗体的方法,其包括步骤:
在更进一步的方面,本发明包括检测胃癌的方法,其包括步骤:
从怀疑患有胃癌的患者准备样品;
用ELISA方法测定GTM蛋白质的存在。
如本文所描述,肿瘤检测可以通过测定一种或更多肿瘤特异性标记物的表达来完成。我们已经意外发现GTM的增强表达与所诊断胃癌存在之间的相关性非常高。检测到的最小显著相关性的p值约1.6×10-6。许多相关性在p值小于10-20时具有意义。由于具有如此高的显著性,就不必检测一种以上GTM的增强表达。然而,本发明过多的GTM能够提高胃癌检测的可靠性。
本文提供的方法还包括高敏感性的测定法。qPCR非常灵敏从而能用来检测样品中拷贝数非常低(例如,1-100)的基因产物。这样的敏感性使得对胃癌相关事件的极早检测成为可能。
方法
下面的普通方法用来评价用于胃癌相关标记物分子鉴定的多种方法的适宜性。
肿瘤收集
从韩国的首尔大学医院和新西兰的Dunedin医院手术切除样品中收集胃肿瘤样品和非恶性胃组织。胃癌诊断是基于症状、体检发现和对组织的组织学检查做出的。
RNA提取
在一些实施方案中,通过测定肿瘤样品中RNA的变化分析胃癌相关基因的表达。将冰冻的手术样品包埋入OCT介质中。使用切片机从组织块中切出60μM厚的切片,放入TriReagent∶水(3∶1)混合物中匀浆,再用氯仿抽提。然后用RneasyTM方法(Qiagen)从水相中纯化总RNA。同样也从16种癌细胞系中提取RNA并且合并后作为参考RNA。
微阵列玻片制备
环氧树脂包被的玻片从MWG Biotech AG(Ebersberg,德国)获得,并且使用Gene Machines微阵列机器人并根据厂商提供的方法在上面印上~30,000条50mer寡核苷酸。图2显示了相关寡核苷酸的参考号(MWGoligo#)以及NCBI mRNA和蛋白质参考序列。下文还显示了本发明GTM的全部DNA序列。
RNA标记和杂交
用Superscript II逆转录酶(Invitrogen)在包含5-(3-氨烷基)-2’-脱氧尿苷-5’-三磷酸的反应中将10μg总RNA转录为cDNA。反应产物经Microcon柱去离子之后,与Cy3或Cy5在碳酸氢缓冲液中室温孵育1小时。经Qiaquick柱(Qiagen)去除未结合的染料,并在SpeedVac中浓缩样品至15μL。然后,Cy3和Cy5标记的cDNA与Ambion ULTRAhyb缓冲液混合,100℃变性2分钟,在杂交盒中与微阵列玻片于42℃杂交16小时。然后洗涤玻片并用Axon 4000A扫描仪在两种功率设置下进行两次扫描产生基因表达的初步荧光数据。
归一化方法
为比较肿瘤组织和非癌组织中癌基因的表达,应用Genepix软件检测的平均荧光强度通过减去局部背景荧光强度得以校正。背景校正强度少于零的点被排除。为了易于归一化,将强度比和总体点强度进行对数(log)转换。对数转换后的强度比通过用LOCFITTM软件包进行局部回归来校正着色误差(dye bias)和空间误差(spatial bias)。对数转换的强度比同时对总体点强度和位置回归。局部回归残差提供了经校正的变化倍数对数值。对于质量控制,每个归一化微阵列的比率对于点强度和位置进行了绘图。随后肉眼检测图中可能的残余假象。另外,应用方差分析(ANOVA)模型来检测针尖误差(pin-tip bias)。将所有归一化结果和参数插入Postgres数据库进行统计学分析。
统计学分析
在肿瘤样品对正常组织中基因表达中的统计学意义变化可通过测定阵列之间的变化倍数进行鉴定。为实现此鉴定,将log2(比率)按比例调整至每个阵列具有相同的总体标准差。此标准化步骤减少了平均的组织种类内变异性。对于每一个寡核苷酸,将log2(比率)进一步转换至中位数值为零的结果从而易于肉眼检察。然后应用以变化倍数为基础的秩检验改善噪音鲁棒性。此检验由两个步骤组成:(i)计算阵列内变化倍数的等级(rankof fold change)(Rfc),和(ii)将肿瘤组织的中值(Rfc)减去正常组织的中值(Rfc)。两个中值等级的差异限定了图2中给出的变化倍数等级的范围。另外两个统计学检验也根据此标准化数据进行:1)进行和不进行Bonferroni调整的两组样品student′s t-检验;和2)Wilcoxon检验。
标记物组合的统计学分析
为了确定使用两种或三种标记物组合区分肿瘤和非恶性肿瘤样品的数值,对来自40份配对样品(来自同一患者的肿瘤样品和非恶性肿瘤样品)的qPCR数据进行下面的分析。使用样品平均值和标准差得到非恶性肿瘤样品和肿瘤样品的正态分布。然后确定来自肿瘤表达数据的值可能超过非恶性肿瘤分布中所规定阈值(例如,大于50%、70%、73%、80%、90%、95%、98%、99%或100%)的可能性(即敏感性)。对于标记物组合,确定了至少一种标记物表达超过阈值的可能性。
表1
名称 | 符号 | AppliedBlosystems的“assay on demand”分析# | 正向引物 | Seq IDNo. | 反向引物 | SeqIDNo. | 探针 | SeqIDNo. |
asporin(1类lrr)硫酸软骨素蛋白聚糖2(多功能蛋白聚糖)半胱氨酸蛋白酶抑制剂SN、SA和Sγ-谷氨酰水解酶胰岛素样生长因子结合蛋白7激肽释放酶10富含亮氨酸脯氨酸的蛋白多糖1(leprecan 1)光亮蛋白聚糖赖氨酰氧化酶样酶2基质金属蛋白酶12金属蛋白酶抑制剂1α-酰基鞘氨醇酰胺水解酶分泌型frizzled相关蛋白2富含半胱氨酸的分泌型酸性蛋白质丝氨酸蛋白酶11(1GF结合)血小板反应蛋白2甲状腺球蛋白具有EF手型结构域1的人细胞生长调节因子人丝氨酸或半胱氨酸蛋白酶抑制剂进化枝B转化生长因子β1人前蛋白转化酶枯草杆茵蛋白酶/kexin类型5基质金属蛋白酶2人丝氨酸或半胱氨酸蛋白酶抑制剂进化枝Hadllcan包含egf的纤蛋白样细胞外基质蛋白质2分泌型frizzled相关蛋白4抑制素βA链骨桥蛋白转化生长因子β诱导蛋白 | ASPNCSPG2CST1,2,4GGHIGFBP7KLK10LEPRE1LUMLOXL2MMP12TIMP1ASAH1SFRP2SPARCPRSS11THBS2TGCGR11SERPINB5TGFB1PCSK5MMP2SERPINH1-EFEMP2SFHP4INHBASPPlTGFB1 | Hs00241844_m1Hs00377849_m1Hs00213545_m1Hs00180066_m1Hs00170103_m1Hs00167093_m1Hs00165908_m1 | AAATACAAAAGGACACATTCAAAGGAGCCAGTGGAATGATGTTCCCAGTCCCAGCCCAACTTGGAGTGGCAATGCCGCTGAACAGGTCAGCAAGGGCACCACAACATGATATGTGCTGGACTGGCTTGAGTACAACGCTGACCTCTTCGATTCTTGTCCATAGTGCATCTGCAGGCCAGCTTCTGCTTGGAGCCTCTCTGCTGATGACATACGTCCAGACCACCTTATACCAGCGCGCAGAACGCCTGCAAACGCTAGCAGCGACCACCTTCTTCCCTGTACACTGGCAGTTCTCGGGAGGCCCGTTAGTAATGGAAGGACTACACGGCCTATAGGACGGTTCCTCGCAGTTCAACTGCCCACCCCTTCCATCCACGCATTTTCCAGGATAAGGTCCATGTCATCACCAATGTTAAAAATCTTTGCCGGAAATGCTTGATGGCATCGCTCAGATC | 12345678910111213141516171819202122 | TGCTTCTGCAATTCTGATATGGATCTTGGCATTTTCTACAACAGGGGGGAACTTCGTAGATCTGGAAAGATGACAGCAACAACTCAGTAGGAAAATCACAGCTCAAGTACACCTGGGGAGAGGATGCCTTGGAGGGTCCGTGACACAGTTCTGCTTACAGCCAATCAATGCCAGGAAGAGACCCTGATCGCCGAGTTGAGTGACAGCATCAAAACTCAAATTGGGACCTGTGGAAGTATCCGCACAGGACATCATACATGGTTTCAAATTTTGCAGGCTTCACATACCTTTGAAAAAGCGGGTGGTGCAAAGGAGATTCCAGCTGTCACTTTCTAGGTTTGGTCATAGATAGGTCCTGAGTTGTAAACCGCTCCACTTCACATTTCTGTCCTTCCTAGTCCCTTTAGGAAGCCGAATTGCTAGTTGCATCTGCAAGTTCATCCCCTCTTTAGTCCTGGCCGTTGAAATACCTGTCACGTGGCGTCACAGT | 23242526272829303132333435363738394041424344 | TTGGAAATGAGTGCAAACCCTCTTGATAATAATGAGGAACAGTTGCTTGCGGCCAGCAGCCAGAACTGCAGAAGAAACAGTTGTGCTTCACTGGAGGTCAATTGCACAGCAGAATAGCAAGGTCCTTCCATAGTGACGCCCCTTGCCAGAGTGACTCTGGAGGCCCCCATCACAGATCATTACATCCAGGTCCTCATAAGGATTCAAACCATTTGCCAAAAATGAGTCTAAGCGTAATTCTTCTGGATGTCTCCTTCACATTCTGTCAGTCCCTGTATGGAGACCCAAAAGAGAACAAGATGACCAAGATGTATAAAGGGTTCCAAGCTGTCTGAACCGCACCAGCCAAGAGAATACTGCCAGCCACCGAGGAAGCTCTGGACCAGCACCCCATTGACGGAGTGTTAATTCCAATCAAACACCGTCCAGGAGGCCCAAGACCGGCTACATCAGAGTCTCTGGCAGATTCCGATGCCCCACAACCAGGCCAGGAGCAGCTCGGTGACTCCAGGCCCGCAATGGACAGCCTCCAGCCAACAGACCTCAGGACAGAATGTAGGGATGGGTTAAGCCTGCATTCAAGGACCGGTTCATTTGGCG | 45464748495051525354555657585960616263646566 |
定量实时PCR
在其它实施方案中,实时PCR或者定量PCR(qPCR)能用来对PCR模板拷贝数进行绝对或相对定量。使用Primer Express V2.0TM(AppliedBiosystems)设计TaqmanTM探针和引物。如果可能,在所得的扩增子中尽可能包括所有潜在的剪接变体,其中扩增子优选为MWG-Biotech来源微阵列寡核苷酸所涵盖的区域。备选地,如果靶基因是由涵盖目的扩增子的Assay-on-Demand表达分析(Applied Biosystems)所给出的,则可使用这些基因。表1和图1显示了基因名称、符号、Applied Biosystems“assayon demand”号、用于qPCR的正向引物、反向引物以及探针序列。在内部设计分析中,使用SYBR绿色标记方法和由参考RNA得到的cDNA滴定引物浓度。在ABI PrismTM 7000序列检测系统中于标准循环条件下进行扩增。当从解离曲线中观察到单一扩增产物时,使用最佳引物浓度和终浓度为250nM 5’FAM-3’TAMRA磷酸TaqmanTM探针(Proligo)可得到超过625倍浓度范围的标准曲线。在后续分析中使用了能够给出回归系数大于0.98的标准曲线的分析法。应该意识到,在其它实施方案中,回归系数不需要如此高。而是可以使用任何标准曲线,只要回归系数高到足以允许测定表达差异的统计学意义即可。在备选的实施方案中,此回归系数可以大于大约0.7、大于大约0.8、大于大约0.9或者大于大约0.95。
在两块96孔板上对代表每一个RNA样品的单一cDNA进行分析。每一块板包括两份的参考cDNA标准曲线,其浓度范围超过625倍。分析包括ΔCT(靶基因CT-平均参考cDNA CT)的计算。ΔCT与变化倍数的log2值的负值成比例。再计算相对于非恶性肿瘤变化倍数log2值中值的变化倍数log2值(倍数变化的log2值-正常的变化倍数log2值的中值)。然后将这些变化倍数以频率分类并作图。
癌症标记物基因的微阵列分析
用Cy5标记来自58份胃肿瘤组织样品和58份非恶性肿瘤(“正常”)胃组织样品的RNA,并与Cy3标记的参考RNA一式两份或一式三份进行杂交。在归一化之后,在29,718个基因中每一个基因的表达变化通过三种测定进行估计:(i)
变化倍数:基因在肿瘤样品中的表达中值(非标准化)除以在非恶性肿瘤样品中的水平中值的比值,(ii)
变化倍数的等级,以及(iii)所观察的倍数变化具有显著性的
统计学概率。
用于胃恶性肿瘤的血清标记物的选择
在某些实施方案中,可以在包括血清在内的生物体液中发现癌症标记物。血清标记物选自阵列数据,其基于(i)以分泌蛋白质或膜外裂解为特征的信号序列的存在,(ii)与非恶性肿瘤对照样品相比,标记物在肿瘤样品中过表达(变化倍数)的水平中值,(iii)标记物在肿瘤样品和非恶性肿瘤对照样品之间表达等级的中值变化,以及(iv)在肿瘤样品和非恶性肿瘤对照样品中表达范围之间的重叠程度。
已知全部29种GTM在其编码序列的5’末端具有信号肽序列。信号序列引导GTM蛋白质通过质膜转运至细胞外区室(Gunner von Heijne,Journal of Molecular Biology 173:243-251(1984))。此外,没有一个GTM具有可导致全长蛋白质滞留在质膜内的跨膜序列基序。因此,本发明的所有GTM标记物很可能分泌至细胞外区室,并因此与脉管系统接触(通过毛细管吸收,或者先转运至淋巴系统然后再转运至脉管系统)。结果,这些肿瘤来源的每一个标记物会出现在血液中。
再者,如果>50%的肿瘤样品显示基因表达水平位于非恶性肿瘤样品范围的第95百分位数之内,则基因被排除。肿瘤样品中过表达程度的变化不仅反映了肿瘤异质性,而且反映了肿瘤样品被“正常”组织(包括肌肉、基质细胞和非恶性上皮腺)污染程度的变化。“正常”污染范围为5-70%,其中值大约为25%。其它基因由于在造血细胞中相对高表达或在化生胃组织中表达增加而被排除。应该意识到,取决于正常细胞或正常表达标记物的细胞的污染程度,可以选择能够使癌症源和正常源充分分离的不同阈值范围。
我们发现有有用GTM包括下面标记物的基因(DNA)、互补DNA(cDNA)、RNA、蛋白质和蛋白质片段,其中所述标记物有:羧肽酶N多肽2,83kDa的链(也称作羧肽酶N(CPN2))、基质金属蛋白酶12(MMP12)、抑制素(“TNHBA”)、胰岛素样生长因子7(“IGFBP7”)、γ谷氨酰水解酶(“GGH”)、富含亮氨酸脯氨酸的蛋白多糖(“LEPRE1”)、半胱氨酸蛋白酶抑制剂S(“CST4”)、分泌型frizzled相关蛋白4(“SFRP4”)、asporin(“ASPN”)、具有EF手型结构域1的细胞生长调节因子(“CGREF1”)、激肽释放酶(“KLK10”)、金属蛋白酶组织抑制剂1(“TIMP1”)、富含半胱氨酸的分泌型酸性蛋白质(“SPARC”)、转化生长因子β诱导蛋白(“TGFBI”)、包含EGF的纤蛋白样细胞外基质蛋白质2(“EFEMP2”)、光亮蛋白聚糖(“LUM”)、stannin(“SNN”)、分泌型磷蛋白1(“SPP1”)、硫酸软骨素蛋白聚糖2(“CSPG2”)、N-酰基鞘氨醇酰胺水解酶(“ASAH1”)、丝氨酸蛋白酶11(“PRSS11”)、分泌型frizzled相关蛋白2(“SFRP2”)、XIIB组磷脂酶A2(“PLA2G12B”)、细胞外基质蛋白质spondin 2(“SPON2”)、嗅介蛋白1(“OLFM1”)、包含重复的血小板反应蛋白1(“TSRC1”)、血小板反应蛋白2(“THBS2”)、adlican、半胱氨酸蛋白酶抑制剂SA(“CST2”)、半胱氨酸蛋白酶抑制剂SN(“CST1”)、赖氨酰氧化酶样酶2(“LOXL2”)、甲状腺球蛋白(“TG”)、转化生长因子β1(“TGFB1”)、丝氨酸或半胱氨酸蛋白酶抑制剂进化枝H(“SERPINH1”)、丝氨酸或半胱氨酸蛋白酶抑制剂进化枝B(“SERPINB5”)、基质金属蛋白酶2(“MMP2”)、前蛋白转化酶枯草杆菌蛋白酶/kexin类型5(“PCSK5”)以及透明质酸糖蛋白连接蛋白4(“HAPLN4”)。
本发明GTM的DNA序列以及鉴定信息一起示于下面。
基质金属蛋白酶12
>gi|4505206|ref|NM_002426.1|人类基质金属蛋白酶12(巨噬细胞弹性蛋白酶)(MMP12),mRNA|qPCR正向引物匹配[758..780]|qPCR反向引物匹配[888..864]|qPCR探针匹配[786..815]
TAGAAGTTTACAATGAAGTTTCTTCTAATACTGCTCCTGCAGGCCACTGCTTCTGGAGCTCTTCCCCTGAACAGCTCTACAAGCCTGGAAAAAAATAATGTGCTATTTGGTGAGAGATACTTAGAAAAATTTTATGGCCTTGAGATAAACAAACTTCCAGTGACAAAAATGAAATATAGTGGAAACTTAATGAAGGAAAAAATCCAAGAAATGCAGCACTTCTTGGGTCTGAAAGTGACCGGGCAACTGGACACATCTACCCTGGAGATGATGCACGCACCTCGATGTGGAGTCCCCGATCTCCATCATTTCAGGGAAATGCCAGGGGGGCCCGTATGGAGGAAACATTATATCACCTACAGAATCAATAATTACACACCTGACATGAACCGTGAGGATGTTGACTACGCAATCCGGAAAGCTTTCCAAGTATGGAGTAATGTTACCCCCTTGAAATTCAGCAAGATTAACACAGGCATGGCTGACATTTTGGTGGTTTTTGCCCGTGGAGCTCATGGAGACTTCCATGCTTTTGATGGCAAAGGTGGAATCCTAGCCCATGCTTTTGGACCTGGATCTGGCATTGGAGGGGATGCACATTTCGATGAGGACGAATTCTGGACTACACATTCAGGAGGCACAAACTTGTTCCTCACTGCTGTTCACGAGATTGGCCATTCCTTAGGTCTTGGCCATTCTAGTGATCCAAAGGCTGTAATGTTCCCCACCTACAAATATGTCGACATCAACACATTTCGCCTCTCTGCTGATGACATACGTGGCATTCAGTCCCTGTATGGAGACCCAAAAGAGAACCAACGCTTGCCAAATCCTGACAATTCAGAACCAGCTCTCTGTGACCCCAATTTGAGTTTTGATGCTGTCACTACCGTGGGAAATAAGATCTTTTTCTTCAAAGACAGGTTCTTCTGGCTGAAGGTTTCTGAGAGACCAAAGACCAGTGTTAATTTAATTTCTTCCTTATGGCCAACCTTGCCATCTGGCATTGAAGCTGCTTATGAAATTGAAGCCAGAAATCAAGTTTTTCTTTTTAAAGATGACAAATACTGGTTAATTAGCAATTTAAGACCAGAGCCAAATTATCCCAAGAGCATACATTCTTTTGGTTTTCCTAACTTTGTGAAAAAAATTGATGCAGCTGTTTTTAACCCACGTTTTTATAGGACCTACTTCTTTGTAGATAACCAGTATTGGAGGTATGATGAAAGGAGACAGATGATGGACCCTGGTTATCCCAAACTGATTACCAAGAACTTCCAAGGAATCGGGCCTAAAATTGATGCAGTCTTCTATTCTAAAAACAAATACTACTATTTCTTCCAAGGATCTAACCAATTTGAATATGACTTCCTACTCCAACGTATCACCAAAACACTGAAAAGCAATAGCTGGTTTGGTTGTTAGAAATGGTGTAATTAATGGTTTTTGTTAGTTCACTTCAGCTTAATAAGTATTTATTGCATATTTGCTATGTCCTCAGTGTACCACTACTTAGAGATATGTATCATAAAAATAAAATCTGTAAACCATAGGTAATGATTATATAAAATACATAATATTTTTCAATTTTGAAAACTCTAATTGTCCATTCTTGCTTGACTCTACTATTAAGTTTGAAAATAGTTACCTTCAAAGCAAGATAATTCTATTTGAAGCATGCTCTGTAAGTTGCTTCCTAACATCCTTGGACTGAGAAATTATACTTACTTCTGGCATAACTAAAATTAAGTATATATATTTTGGCTCAAATAAAATTG SEQ ID NO:67
抑制素βA
>gi|4504698|ref|NM_002192.1|人类抑制素,βA(激活蛋白A、激活蛋白ABα多肽)(INHBA),mRNA|qPCR据assay_on_demand情况匹配[457..481]
TCCACACACACAAAAAACCTGCGCGTGAGGGGGGAGGAAAAGCAGGGCCTTTAAAAAGGCAATCACAACAACTTTTGCTGCCAGGATGCCCTTGCTTTGGCTGAGAGGATTTCTGTTGGCAAGTTGCTGGATTATAGTGAGGAGTTCCCCCACCCCAGGATCCGAGGGGCACAGCGCGGCCCCCGACTGTCCGTCCTGTGCGCTGGCCGCCCTCCCAAAGGATGTACCCAACTCTCAGCCAGAGATGGTGGAGGCCGTCAAGAAGCACATTTTAAACATGCTGCACTTGAAGAAGAGACCCGATGTCACCCAGCCGGTACCCAAGGCGGCGCTTCTGAACGCGATCAGAAAGCTTCATGTGGGCAAAGTCGGGGAGAACGGGTATGTGGAGATAGAGGATGACATTGGAAGGAGGGCAGAAATGAATGAACTTATGGAGCAGACCTCGGAGATCATCACGTTTGCCGAGTCAGGAACAGCCAGGAAGACGCTGCACTTCGAGATTTCCAAGGAAGGCAGTGACCTGTCAGTGGTGGAGCGTGCAGAAGTCTGGCTCTTCCTAAAAGTCCCCAAGGCCAACAGGACCAGGACCAAAGTCACCATCCGCCTCTTCCAGCAGCAGAAGCACCCGCAGGGCAGCTTGGACACAGGGGAAGAGGCCGAGGAAGTGGGCTTAAAGGGGGAGAGGAGTGAACTGTTGCTCTCTGAAAAAGTAGTAGACGCTCGGAAGAGCACCTGGCATGTCTTCCCTGTCTCCAGCAGCATCCAGCGGTTGCTGGACCAGGGCAAGAGCTCCCTGGACGTTCGGATTGCCTGTGAGCAGTGCCAGGAGAGTGGCGCCAGCTTGGTTCTCCTGGGCAAGAAGAAGAAGAAAGAAGAGGAGGGGGAAGGGAAAAAGAAGGGCGGAGGTGAAGGTGGGGCAGGAGCAGATGAGGAAAAGGAGCAGTCGCACAGACCTTTCCTCATGCTGCAGGCCCGGCAGTCTGAAGACCACCCTCATCGCCGGCGTCGGCGGGGCTTGGAGTGTGATGGCAAGGTCAACATCTGCTGTAAGAAACAGTTCTTTGTCAGTTTCAAGGACATCGGCTGGAATGACTGGATCATTGCTCCCTCTGGCTATCATGCCAACTACTGCGAGGGTGAGTGCCCGAGCCATATAGCAGGCACGTCCGGGTCCTCACTGTCCTTCCACTCAACAGTCATCAACCACTACCGCATGCGGGGCCATAGCCCCTTTGCCAACCTCAAATCGTGCTGTGTGCCCACCAAGCTGAGACCCATGTCCATGTTGTACTATGATGATGGTCAAAACATCATCAAAAAGGACATTCAGAACATGATCGTGGAGGAGTGTGGGTGCTCATAGAGTTGCCCAGCCCAGGGGGAAAGGGAGCAAGAGTTGTCCAGAGAAGACAGTGGCAAAATGAAGAAATTTTTAAGGTTTCTGAGTTAACCAGAAAAATAGAAATTAAAAACAAAACAAAACAAAAAAAAAAACAAAAAAAAACAAAAGTAAATTAAAAACAAACCTGATGAAACAGATGAAACAGATGAAGGAAGATGTGGAAATCTTAGCCTGCCTTAGCCAGGGCTCAGAGATGAAGCAGTGAAGAGACAGATTGGGAGGGAAAGGGAGAATGGTGTACCCTTTATTTCTTCTGAAATCACACTGATGACATCAGTTGTTTAAACGGGGTATTGTCCTTTCCCCCCTTGAGGTTCCCTTGTGAGCTTGAATCAACCAATCTGATCTGCAGTAGTGTGGACTAGAACAACCCAAATAGCATCTAGAAAGCCATGAGTTTGAAAGGGCCCATCACAGGCACTTTCCTAGCCTAAT SEQ ID NO:68
胰岛素样生长因子结合蛋白7
>gi|4504618|ref|NM_001553.1|人类胰岛素样生长因子结合蛋白7(IGFBP7),mRNA|qPCR正向引物匹配[470..487]|qPCR反向引物匹配[567..546]|qPCR探针匹配[492..517]
GCCGCTGCCACCGCACCCCGCCATGGAGCGGCCGTCGCTGCGCGCCCTGCTCCTCGGCGCCGCTGGGCTGCTGCTCCTGCTCCTGCCCCTCTCCTCTTCCTCCTCTTCGGACACCTGCGGCCCCTGCGAGCCGGCCTCCTGCCCGCCCCTGCCCCCGCTGGGCTGCCTGCTGGGCGAGACCCGCGACGCGTGCGGCTGCTGCCCTATGTGCGCCCGCGGCGAGGGCGAGCCGTGCGGGGGTGGCGGCGCCGGCAGGGGGTACTGCGCGCCGGGCATGGAGTGCGTGAAGAGCCGCAAGAGGCGGAAGGGTAAAGCCGGGGCAGCAGCCGGCGGTCCGGGTGTAAGCGGCGTGTGCGTGTGCAAGAGCCGCTACCCGGTGTGCGGCAGCGACGGCACCACCTACCCGAGCGGCTGCCAGCTGCGCGCCGCCAGCCAGAGGGCCGAGAGCCGCGGGGAGAAGGCCATCACCCAGGTCAGCAAGGGCACCTGCGAGCAAGGTCCTTCCATAGTGACGCCCCCCAAGGACATCTGGAATGTCACTGGTGCCCAGGTGTACTTGAGCTGTGAGGTCATCGGAATCCCGACACCTGTCCTCATCTGGAACAAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAACTCCTGCCTGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGCCCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGGTATCTCCTCTAAGTAAGGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCCCAAGGACAGGCTTCAGCATCAGCAAAAATTACAGTGGTTGATGCCTTACATGAAATACCAGTGAAAAAAGGTGAAGGTGCCGAGCTATAAACCTCCAGAATATTATTAGTCTGCATGGTTAAAAGTAGTCATGGATAACTACATTACCTGTTCTTGCCTAATAAGTTTCTTTTAATCCAATCCACTAACACTTTAGTTATATTCACTGGTTTTACACAGAGAAATACAAAATAAAGATCACACATCAAGACTATCTACAAAAATTTATTATATATTTACAGAAGAAAAGCATGCATATCATTAAACAAATAAAATACTTTTTATCACAAAAAAAAAAAAAAAA SEQ ID NO:69
γ谷氨酰水解酶
>gi|4503986|ref|NM_003878.1|人类γ谷氨酰水解酶(结合酶、叶酰聚γ谷氨酰水解酶)(GGH),mRNA|qPCR正向引物匹配[531..547]|qPCR反向引物匹配[611..587]|qPCR探针匹配[549..577]
TGCCGCAGCCCCCGCCCGCCCGCAGAGCTTTTGAAAGGCGGCGGGAGGCGGCGAGCGCCATGGCCAGTCCGGGCTGCCTGCTGTGCGTGCTGGGCCTGCTACTCTGCGGGGCGGCGAGCCTCGAGCTGTCTAGACCCCACGGCGACACCGCCAAGAAGCCCATCATCGGAATATTAATGCAAAAATGCCGTAATAAAGTCATGAAAAACTATGGAAGATACTATATTGCTGCGTCCTATGTAAAGTACTTGGAGTCTGCAGGTGCGAGAGTTGTACCAGTAAGGCTGGATCTTACAGAGAAAGACTATGAAATACTTTTCAAATCTATTAATGGAATCCTTTTCCCTGGAGGAAGTGTTGACCTCAGACGCTCAGATTATGCTAAAGTGGCCAAAATATTTTATAACTTGTCCATACAGAGTTTTGATGATGGAGACTATTTTCCTGTGTGGGGCACATGCCTTGGATTTGAAGAGCTTTCACTGCTGATTAGTGGAGAGTGCTTATTAACTGCCACAGATACTGTTGACGTGGCAATGCCGCTGAACTTCACTGGAGGTCAATTGCACAGCAGAATGTTCCAGAATTTTCCTACTGAGTTGTTGCTGTCATTAGCAGTAGAACCTCTGACTGCCAATTTCCATAAGTGGAGCCTCTCCGTGAAGAATTTTACAATGAATGAAAAGTTAAAGAAGTTTTTCAATGTCTTAACTACAAATACAGATGGCAAGATTGAGTTTATTTCAACAATGGAAGGATATAAGTATCCAGTATATGGTGTCCAGTGGCATCCAGAGAAAGCACCTTATGAGTGGAAGAATTTGGATGGCATTTCCCATGCACCTAATGCTGTGAAAACCGCATTTTATTTAGCAGAGTTTTTTGTTAATGAAGCTCGGAAAAACAACCATCATTTTAAATCTGAATCTGAAGAGGAGAAAGCATTGATTTATCAGTTCAGTCCAATTTATACTGGAAATATTTCTTCATTTCAGCAATGTTACATATTTGATTGAAAGTCTTCAATTTGTTAACAGAGCAAATTTGAATAATTCCATGATTAAACTGTTAGAATAACTTGCTACTCATGGCAAGATTAGGAAGTCACAGATTCTTTTCTATAATGTGCCTGGCTCTGATTCTTCATTATGTATGTGACTATTTATATAACATTAGATAATTAAATAGTGAGACATAAATAGAGTGCTTTTTCATGGAAAAGCCTTCTTATATCTGAAGATTGAAAAATAAATTTACTGAAATACAAAAAAAAAAAAAAA
SEQ ID NO:70
富含亮氨酸脯氨酸的蛋白多糖1
>gi|21361917|ref|NM_022356.2|人类富含亮氨酸脯氨酸的蛋白多糖(leprecan)1(LEPRE1),mRNA|qPCR正向引物匹配[813..836]|qPCR反向引物匹配[894..872]|qPCR探针匹配[841..870]
GGTGGCGGGTGGCTGGCGGTTCCGTTAGGTCTGAGGGAGCGATGGCGGTACGCGCGTTGAAGCTGCTGACCACACTGCTGGCTGTCGTGGCCGCTGCCTCCCAAGCCGAGGTCGAGTCCGAGGCAGGATGGGGCATGGTGACGCCTGATCTGCTCTTCGCCGAGGGGACCGCAGCCTACGCGCGCGGGGACTGGCCCGGGGTGGTCCTGAGCATGGAACGGGCGCTGCGCTCCCGGGCAGCCCTCCGCGCCCTTCGCCTGCGCTGCCGCACCCAGTGTGCCGCCGACTTCCCGTGGGAGCTGGACCCCGACTGGTCCCCCAGCCCGGCCCAGGCCTCGGGCGCCGCCGCCCTGCGCGACCTGAGCTTCTTCGGGGGCCTTCTGCGTCGCGCTGCCTGCCTGCGCCGCTGCCTCGGGCCGCCGGCCGCCCACTCGCTCAGCGAAGAGATGGAGCTGGAGTTCCGCAAGCGGAGCCCCTACAACTACCTGCAGGTCGCCTACTTCAAGATCAACAAGTTGGAGAAAGCTGTTGCTGCAGCACACACCTTCTTCGTGGGCAATCCTGAGCACATGGAAATGCAGCAGAACCTAGACTATTACCAAACCATGTCTGGAGTGAAGGAGGCCGACTTCAAGGATCTTGAGACTCAACCCCATATGCAAGAATTTCGACTGGGAGTGCGACTCTACTCAGAGGAACAGCCACAGGAAGCTGTGCCCCACCTAGAGGCGGCGCTGCAAGAATACTTTGTGGCCTATGAGGAGTGCCGTGCCCTCTGCGAAGGGCCCTATGACTACGATGGCTACAACTACCTTGAGTACAACGCTGACCTCTTCCAGGCCATCACAGATCATTACATCCAGGTCCTCAACTGTAAGCAGAACTGTGTCACGGAGCTTGCTTCCCACCCAAGTCGAGAGAAGCCCTTTGAAGACTTCCTCCCATCGCATTATAATTATCTGCAGTTTGCCTACTATAACATTGGGAATTATACACAGGCTGTTGAATGTGCCAAGACCTATCTTCTCTTCTTCCCCAATGACGAGGTGATGAACCAAAATTTGGCCTATTATGCAGCTATGCTTGGAGAAGAACACACCAGATCCATCGGCCCCCGTGAGAGTGCCAAGGAGTACCGACAGCGAAGCCTACTGGAAAAAGAACTGCTTTTCTTCGCTTATGATGTTTTTGGAATTCCCTTTGTGGATCCGGATTCATGGACTCCAGGAGAAGTGATTCCCAAGAGATTGCAAGAGAAACAGAAGTCAGAACGGGAAACAGCCGTACGCATCTCCCAGGAGATTGGGAACCTTATGAAGGAAATCGAGACCCTTGTGGAAGAGAAGACCAAGGAGTCACTGGATGTGAGCAGACTGACCCGGGAAGGTGGCCCCCTGCTGTATGAAGGCATCAGTCTCACCATGAACTCCAAACTCCTGAATGGTTCCCAGCGGGTGGTGATGGACGGCGTAATCTCTGACCACGAGTGTCAGGAGCTGCAGAGACTGACCAATGTGGCAGCAACCTCAGGAGATGGCTACCGGGGTCAGACCTCCCCACATACTCCCAATGAAAAGTTCTATGGTGTCACTGTCTTCAAAGCCCTCAAGCTGGGGCAAGAAGGCAAAGTTCCTCTGCAGAGTGCCCACCTGTACTACAACGTGACGGAGAAGGTGCGGCGCATCATGGAGTCCTACTTCCGCCTGGATACGCCCCTCTACTTTTCCTACTCTCATCTGGTGTGCCGCACTGCCATCGAAGAGGTCCAGGCAGAGAGGAAGGATGATAGTCATCCAGTCCACGTGGACAACTGCATCCTGAATGCCGAGACCCTCGTGTGTGTCAAAGAGCCCCCAGCCTACACCTTCCGCGACTACAGCGCCATCCTTTACCTAAATGGGGACTTCGATGGCGGAAACTTTTATTTCACTGAACTGGATGCCAAGACCGTGACGGCAGAGGTGCAGCCTCAGTGTGGAAGAGCCGTGGGATTCTCTTCAGGCACTGAAAACCCACATGGAGTGAAGGCTGTCACCAGGGGGCAGCGCTGTGCCATCGCCCTGTGGTTCACCCTGGACCCTCGACACAGCGAGCGGGTGAGAGCAGCTCGAGCGGGTGAGAGCAGCTGGTGCTGTGGTGACCCGTTCCCAGAGCGCCCTTGGTTTGCCTTTCTCTTCCCCAAATCCCATTGCCAGTGGCTGAGACACGAAAGGAGCACTTGGGACACCAGCTCCAACGCCCTGTCATTATGGTCACATTGCCTTGTCCTCCCTGGGCCTGCTGTGAACGGGATCCAGGTGGGGAAAGAGGTCAAGACAGGGAGCGATGCTGAGTTCTTGGTTCCCTCCTTGGGCCCCACTTCAGCTGTCCTTTTCCAGAGAGTAGGACCTGCTGGGAAGGAGATGAGCCTGGGGCCATTAAGGAACCTTCCTTGTCCCCTGGGAAGTAGCAGCTGAGAGATAGCGAGTGTCTGGAGCGGAGGCCTCTCTGAATGGGCAGGGGTTTGTCCTTGCAGGACAGGGTGCAGGCAGATGACCTGGTGAAGATGCTCTTCAGCCCAGAAGAGATGGTCCTCTCCCAGGAGCAGCCCCTGGATGCCCAGCAGGGCCCCCCCGAACCTGCACAAGAGTCTCTCTCAGGCAGTGAATCGAAGCCCAAGGATGAGCTATGACAGCGTCCAGGTCAGACGGATGGGTGACTAGACCCATGGAGAGGAACTCTTCTGCACTCTGAGCTGGCCAGCCCCTCGGGGCTGCAGAGCAGTGAGCCTACATCTGCCACTCAGCCGAGGGGACCCTGCTCACAGCCTTCTACATGGTGCTACTGCTCTTGGAGTGGACATGACCAGACACCGCACCCCCTGGATCTGGCTGAGGGCTCAGGACACAGGCCCAGCCACCCCCAGGGGCCTCCACAGGCCGCTGCATAACAGCGATACAGTACTTAAGTGTCTGTGTAGACAACCAAAGAATAAATGATTCATGGTTTTTTTT SEQ ID NO:71
半胱氨酸蛋白酶抑制剂S
>gi|19882254|ref|NM_001899.2|人类半胱氨酸蛋白酶抑制剂S(CST4),mRNA|qPCR正向引物匹配[343..361]|qPCR反向引物匹配[434..411]|qPCR探针匹配[382..410]
GGCTCTCACCCTCCTCTCCTGCAGCTCCAGCTTTGTGCTCTGCCTCTGAGGAGACCATGGCCCGGCCTCTGTGTACCCTGCTACTCCTGATGGCTACCCTGGCTGGGGCTCTGGCCTCGAGCTCCAAGGAGGAGAATAGGATAATCCCAGGTGGCATCTATGATGCAGACCTCAATGATGAGTGGGTACAGCGTGCCCTTCACTTCGCCATCAGCGAGTACAACAAGGCCACCGAAGATGAGTACTACAGACGCCCGCTGCAGGTGCTGCGAGCCAGGGAGCAGACCTTTGGGGGGGTGAATTACTTCTTCGACGTAGAGGTGGGCCGCACCATATGTACCAAGTCCCAGCCCAACTTGGACACCTGTGCCTTCCATGAACAGCCAGAACTGCAGAAGAAACAGTTGTGCTCTTTCGAGATCTACGAAGTTCCCTGGGAGGACAGAATGTCCCTGGTGAATTCCAGGTGTCAAGAAGCCTAGGGGTCTGTGCCAGGCCAGTCACACCGACCACCACCCACTCCCACCCACTGTAGTGCTCCCACCCCTGGACTGGTGGCCCCCACCCTGCGGGAGGCCTCCCCATGTGCCTGTGCCAAGAGACAGACAGAGAAGGCTGCAGGAGTCCTTTGTTGCTCAGCAGGGCGCTCTGCCCTCCCTCCTTCCTTCTTGCTTCTAATAGACCTGGTACATGGTACACACACCCCCACCTCCTGCAATTAAACAGTAGCATCGCC
SEQ ID NO:72
分泌型frizzled相关蛋白4
>gi|8400733|ref|NM_003014.2|人类分泌型frizzled相关蛋白4(SFRP4),mRNA|qPCR据assay_on_demand情况匹配[1079..1103]
GGCGGGTTCGCGCCCCGAAGGCTGAGAGCTGGCGCTGCTCGTGCCCTGTGTGCCAGACGGCGGAGCTCCGCGGCCGGACCCCGCGGCCCCGCTTTGCTGCCGACTGGAGTTTGGGGGAAGAAACTCTCCTGCGCCCCAGAAGATTTCTTCCTCGGCGAAGGGACAGCGAAAGATGAGGGTGGCAGGAAGAGAAGGCGCTTTCTGTCTGCCGGGGTCGCAGCGCGAGAGGGCAGTGCCATGTTCCTCTCCATCCTAGTGGCGCTGTGCCTGTGGCTGCACCTGGCGCTGGGCGTGCGCGGCGCGCCCTGCGAGGCGGTGCGCATCCCTATGTGCCGGCACATGCCCTGGAACATCACGCGGATGCCCAACCACCTGCACCACAGCACGCAGGAGAACGCCATCCTGGCCATCGAGCAGTACGAGGAGCTGGTGGACGTGAACTGCAGCGCCGTGCTGCGCTTCTTCTTCTGTGCCATGTACGCGCCCATTTGCACCCTGGAGTTCCTGCACGACCCTATCAAGCCGTGCAAGTCGGTGTGCCAACGCGCGCGCGACGACTGCGAGCCCCTCATGAAGATGTACAACCACAGCTGGCCCGAAAGCCTGGCCTGCGACGAGCTGCCTGTCTATGACCGTGGCGTGTGCATTTCGCCTGAAGCCATCGTCACGGACCTCCCGGAGGATGTTAAGTGGATAGACATCACACCAGACATGATGGTACAGGAAAGGCCTCTTGATGTTGACTGTAAACGCCTAAGCCCCGATCGGTGCAAGTGTAAAAAGGTGAAGCCAACTTTGGCAACGTATCTCAGCAAAAACTACAGCTATGTTATTCATGCCAAAATAAAAGCTGTGCAGAGGAGTGGCTGCAATGAGGTCACAACGGTGGTGGATGTAAAAGAGATCTTCAAGTCCTCATCACCCATCCCTCGAACTCAAGTCCCGCTCATTACAAATTCTTCTTGCCAGTGTCCACACATCCTGCCCCATCAAGATGTTCTCATCATGTGTTACGAGTGGCGTTCAAGGATGATGCTTCTTGAAAATTGCTTAGTTGAAAAATGGAGAGATCAGCTTAGTAAAAGATCCATACAGTGGGAAGAGAGGCTGCAGGAACAGCGGAGAACAGTTCAGGACAAGAAGAAAACAGCCGGGCGCACCAGTCGTAGTAATCCCCCCAAACCAAAGGGAAAGCCTCCTGCTCCCAAACCAGCCAGTCCCAAGAAGAACATTAAAACTAGGAGTGCCCAGAAGAGAACAAACCCGAAAAGAGTGTGAGCTAACTAGTTTCCAAAGCGGAGACTTCCGACTTCCTTACAGGATGAGGCTGGGCATTGCCTGGGACAGCCTATGTAAGGCCATGTGCCCCTTGCCCTAACAACTCACTGCAGTGCTCTTCATAGACACATCTTGCAGCATTTTTCTTAAGGCTATGCTTCAGTTTTTCTTTGTAAGCCATCACAAGCCATAGTGGTAGGTTTGCCCTTTGGTACAGAAGGTGAGTTAAAGCTGGTGGAAAAGGCTTATTGCATTGCATTCAGAGTAACCTGTGTGCATACTCTAGAAGAGTAGGGAAAATAATGCTTGTTACAATTCGACCTAATATGTGCATTGTAAAATAAATGCCATATTTCAAACAAAACACGTAATTTTTTTACAGTATGTTTTATTACCTTTTGATATCTGTTGTTGCAATGTTAGTGATGTTTTAAAATGTGATGAAAATATAATGTTTTTAAGAAGGAACAGTAGTGGAATGAATGTTAAAAGATCTTTATGTGTTTATGGTCTGCAGAAGGATTTTTGTGATGAAAGGGGATTTTTTGAAAAATTAGAGAAGTAGCATATGGAAAATTATAATGTGTTTTTTTACCAATGACTTCAGTTTCTGTTTTTAGCTAGAAACTTAAAAACAAAAATAATAATAAAGAAAAATAAATAAAAAGGAGAGGCAGACAATGTCTGGATTCCTGTTTTTTGGTTACCTGATTTCCATGATCATGATGCTTCTTGTCAACACCCTCTTAAGCAGCACCAGAAACAGTGAGTTTGTCTGTACCATTAGGAGTTAGGTACTAATTAGTTGGCTAATGCTCAAGTATTTTATACCCACAAGAGAGGTATGTCACTCATCTTACTTCCCAGGACATCCACCCTGAGAATAATTTGACAAGCTTAAAAATGGCCTTCATGTGAGTGCCAAATTTTGTTTTTCTTCATTTAAATATTTTCTTTGCCTAAATACATGTGAGAGGAGTTAAATATAAATGTACAGAGAGGAAAGTTGAGTTCCACCTCTGAAATGAGAATTACTTGACAGTTGGGATACTTTAATCAGAAAAAAAGAACTTATTTGCAGCATTTTATCAACAAATTTCATAATTGTGGACAATTGGAGGCATTTATTTTAAAAAACAATTTTATTGGCCTTTTGCTAACACAGTAAGCATGTATTTTATAAGGCATTCAATAAATGCACAACGCCCAAAGGAAATAAAATCCTATCTAATCCTACTCTCCACTACACAGAGGTAATCACTATTAGTATTTTGGCATATTATTCTCCAGGTGTTTGCTTATGCACTTATAAAATGATTTGAACAAATAAAACTAGGAACCTGTATACATGTGTTTCATAACCTGCCTCCTTTGCTTGGCCCTTTATTGAGATAAGTTTTCCTGTCAAGAAAGCAGAAACCATCTCATTTCTAACAGCTGTGTTATATTCCATAGTATGCATTACTCAACAAACTGTTGTGCTATTGGATACTTAGGTGGTTTCTTCACTGACAATACTGAATAAACATCTCACCGGAATTC
SEQ ID NO:73
Asporin
>gi|41350213|ref|NM_017680.3|人类asporin(1类LRR)(ASPN),mRNA|qPCR正向引物匹配[798..823]|qPCR反向引物匹配[934..912]|qPCR探针匹配[842..875]
AGTACTAACATGGACTAATCTGTGGGAGCAGTTTATTCCAGTATCACCCAGGGTGCAGCCACACCAGGACTGTGTTGAAGGGTGTTTTTTTTCTTTTAAATGTAATACCTCCTCATCTTTTCTTCTTACACAGTGTCTGAGAACATTTACATTATAGATAAGTAGTACATGGTGGATAACTTCTACTTTTAGGAGGACTACTCTCTTCTGACAGTCCTAGACTGGTCTTCTACACTAAGACACCATGAAGGAGTATGTGCTCCTATTATTCCTGGCTTTGTGCTCTGCCAAACCCTTCTTTAGCCCTTCACACATCGCACTGAAGAATATGATGCTGAAGGATATGGAAGACACAGATGATGATGATGATGATGATGATGATGATGATGATGATGATGAGGACAACTCTCTTTTTCCAACAAGAGAGCCAAGAAGCCATTTTTTTCCATTTGATCTGTTTCCAATGTGTCCATTTGGATGTCAGTGCTATTCACGAGTTGTACATTGCTCAGATTTAGGTTTGACCTCAGTCCCAACCAACATTCCATTTGATACTCGAATGCTTGATCTTCAAAACAATAAAATTAAGGAAATCAAAGAAAATGATTTTAAAGGACTCACTTCACTTTATGGTCTGATCCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTTCTAACCACAAAGAAGTTGCGAAGGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAACTCAGAATTCATGAAAATAAAGTTAAGAAAATACAAAAGGACACATTCAAAGGAATGAATGCTTTACACGTTTTGGAAATGAGTGCAAACCCTCTTGATAATAATGGGATAGAGCCAGGGGCATTTGAAGGGGTGACGGTGTTCCATATCAGAATTGCAGAAGCAAAACTGACCTCAGTTCCTAAAGGCTTACCACCAACTTTATTGGAGCTTCACTTAGATTATAATAAAATTTCAACAGTGGAACTTGAGGATTTTAAACGATACAAAGAACTACAAAGGCTGGGCCTAGGAAACAACAAAATCACAGATATCGAAAATGGGAGTCTTGCTAACATACCACGTGTGAGAGAAATACATTTGGAAAACAATAAACTAAAAAAAATCCCTTCAGGATTACCAGAGTTGAAATACCTCCAGATAATCTTCCTTCATTCTAATTCAATTGCAAGAGTGGGAGTAAATGACTTCTGTCCAACAGTGCCAAAGATGAAGAAATCTTTATACAGTGCAATAAGTTTATTCAACAACCCGGTGAAATACTGGGAAATGCAACCTGCAACATTTCGTTGTGTTTTGAGCAGAATGAGTGTTCAGCTTGGGAACTTTGGAATGTAATAATTAGTAATTGGTAATGTCCATTTAATATAAGATTCAAAAATCCCTACATTTGGAATACTTGAACTCTATTAATAATGGTAGTATTATATATACAAGCAAATATCTATTCTCAAGTGGTAAGTCCACTGACTTATTTTATGACAAGAAATTTCAACGGAATTTTGCCAAACTATTGATACATAAGGGTTGAGAGAAACAAGCATCTATTGCAGTTTCTTTTTGCGTACAAATGATCTTACATAAATCTCATGCTTGACCATTCCTTTCTTCATAACAAAAAAGTAAGATATTCGGTATTTAACACTTTGTTATCAAGCATATTTTAAAAAGAACTGTACTGTAAATGGAATGCTTGACTTAGCAAAATTTGTGCTCTTTCATTTGCTGTTAGAAAAACAGAATTAACAAAGACAGTAATGTGAAGAGTGCATTACACTATTCTTATTCTTTAGTAACTTGGGTAGTACTGTAATATTTTTAATCATCTTAAAGTATGATTTGATATAATCTTATTGAAATTACCTTATCATGTCTTAGAGCCCGTCTTTATGTTTAAAACTAATTTCTTAAAATAAAGCCTTCAGTAAATGTTCATTACCAACTTGATAAATGCTACTCATAAGAGCTGGTTTGGGGCTATAGCATATGCTTTTTTTTTTTTAATTATTACCTGATTTAAAAATCTCTGTAAAAACGTGTAGTGTTTCATAAAATCTGTAACTCGCATTTTAATGATCCGCTATTATAAGCTTTTAATAGCATGAAAATTGTTAGGCTATATAACATTGCCACTTCAACTCTAAGGAATATTTTTGAGATATCCCTTTGGAAGACCTTGCTTGGAAGAGCCTGGACACTAACAATTCTACACCAAATTGTCTCTTCAAATACGTATGGACTGGATAACTCTGAGAAACACATCTAGTATAACTGAATAAGCAGAGCATCAAATTAAACAGACAGAAACCGAAAGCTCTATATAAATGCTCAGAGTTCTTTATGTATTTCTTATTGGCATTCAACATATGTAAAATCAGAAAACAGGGAAATTTTCATTAAAAATATTGGTTTGAAATAAAAAAAAAAAAAA
SEQ ID NO:74
具有EF手型结构域1的细胞生长调节因子
>gi|33589823|ref|NM_006569.2|人类具有EF手型结构域1的细胞生长调节因子(CGREF1),mRNA|qPCR正向引物匹配[378..394]|qPCR反向引物匹配[455..431]|qPCR探针匹配[396..415]
CGCGCAGCCCCTCCGGCCGCGGGCGCAGCGGGGGCGCTGGTGGAGCTGCGAAGGGCCAGGTCCGGCGGGCGGGGCGGCGGCTGGCACTGGCTCCGGACTCTGCCCGGCCAGGGCGGCGGCTCCAGCCGGGAGGGCGACGTGGAGCGGCCACGTGGAGCGGCCCGGGGGAGGCTGGCGGCGGGAGGCGAGGCGCGGGCGGCGCAGCAGCCAGGAGCGCCCACGGAGCTGGACCCCCAGAGCCGCGCGGCGCCGCAGCAGTTCCAGGAAGGATGTTACCTTTGACGATGACAGTGTTAATCCTGCTGCTGCTCCCCACGGGTCAGGCTGCCCCAAAGGATGGAGTCACAAGGCCAGACTCTGAAGTGCAGCATCAGCTCCTGCCCAACCCCTTCCAGCCAGGCCAGGAGCAGCTCGGACTTCTGCAGAGCTACCTAAAGGGACTAGGAAGGACAGAAGTGCAACTGGAGCATCTGAGCCGGGAGCAGGTTCTCCTCTACCTCTTTGCCCTCCATGACTATGACCAGAGTGGACAGCTGGATGGCCTGGAGCTGCTGTCCATGTTGACAGCTGCTCTGGCCCCTGGAGCTGCCAACTCTCCTACCACCAACCCGGTGATATTGATAGTGGACAAAGTGCTCGAGACGCAGGACCTGAATGGGGATGGGCTCATGACCCCTGCTGAGCTCATCAACTTCCCGGGAGTAGCCCTCAGGCACGTGGAGCCCGGAGAGCCCCTTGCTCCATCTCCTCAGGAGCCACAAGCTGTTGGAAGGCAGTCCCTATTAGCTAAAAGCCCATTAAGACAAGAAACACAGGAAGCCCCTGGTCCCAGAGAAGAAGCAAAGGGCCAGGTAGAGGCCAGAAGGGAGTCTTTGGATCCTGTCCAGGAGCCTGGGGGCCAGGCAGAGGCTGATGGAGATGTTCCAGGGCCCAGAGGGGAAGCTGAGGGCCAGGCAGAGGCTAAAGGAGATGCCCCTGGGCCCAGAGGGGAAGCTGGGGGCCAGGCAGAGGCTGAAGGAGATGCCCCCGGGCCCAGAGGGGAAGCTGGGGGCCAGGCAGAGGCCAGGGAGAATGGAGAGGAGGCCAAGGAACTTCCAGGGGAAACACTGGAGTCTAAGAACACCCAAAATGACTTTGAGGTGCACATTGTTCAAGTGGAGAATGATGAGATCTAGATCTTGAAGATACAGGTACCCCACGAAGTCTCAGTGCCAGAACATAAGCCCTGAAGTGGGCAGGGGAAATGTACGCTGGGACAAGGACCATCTCTGTGCCCCCTGTCTGGTCCCAGTAGGTATCAGGTCTTTCTGTGCAGCTCAGGGAGACCCTAAGTTAAGGGGCAGATTACCAATAAAGAACTGAATGAATTCATCCCCCCGGGCCACCTCTCTACCCGTCCAGCCTGCCCAGACCCTCTCAGAGGAACGGGGTTGGGGACCGAAAGGACAGGGATGCCGCCTGCCCAGTGTTTCTGGGCCTCACGGTGCTCCGGCAGCAGAGCGCATGGTGCTAGCCATGGCCGGCTGCAGAGGACCCAGTGAGGAAAGCTCAGTCTATCCCTGGGCCCCAAACCCTCACCGGTTCCCCCTCACCTGGTGTTCAGACACCCCATGCTCTCCTGCAGCTCAGGGCAGGTGACCCCATCCCCAGTAATATTAATCATCACTAGAACTTTTTGAGAGCCTTGTACACATCAGGCATCATGCTGGGCATTTTATATATGATTTTATCCTCACAATAATTCTGTAGCCAAGCAGAATTGGTTCCATTTGACAGATGAAGAAATTGAGGCAGATTGCGTTAAGTGCTGTACCCTAAGGTGATATGCAGCTAATTAAATGGCAGATTTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA SEQ ID NO:75
激肽释放酶10,转录物变体1
>gi|22208981|ref|NM_002776.3|人类激肽释放酶10(KLK10),转录物变体1,mRNA|qPCR正向引物匹配[851..874]|qPCR反向引物匹配[950..931]|qPCR探针匹配[890..914]
CATCCTGCCACCCCTAGCCTTGCTGGGGACGTGAACCCTCTCCCCGCGCCTGGGAAGCCTTCTTGGCACCGGGACCCGGAGAATCCCCACGGAAGCCAGTTCCAAAAGGGATGAAAAGGGGGCGTTTCGGGCACTGGGAGAAGCCTGTATTCCAGGGCCCCTCCCAGAGCAGGAATCTGGGACCCAGGAGTGCCAGCCTCACCCACGCAGATCCTGGCCATGAGAGCTCCGCACCTCCACCTCTCCGCCGCCTCTGGCGCCCGGGCTCTGGCGAAGCTGCTGCCGCTGCTGATGGCGCAACTCTGGGCCGCAGAGGCGGCGCTGCTCCCCCAAAACGACACGCGCTTGGACCCCGAAGCCTATGGCTCCCCGTGCGCGCGCGGCTCGCAGCCCTGGCAGGTCTCGCTCTTCAACGGCCTCTCGTTCCACTGCGCGGGTGTCCTGGTGGACCAGAGTTGGGTGCTGACGGCCGCGCACTGCGGAAACAAGCCACTGTGGGCTCGAGTAGGGGATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCGGACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCCCATCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCTGAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCAGCTTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGTTGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGGCCTGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTGTGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGGACTGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGGCCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGTTTACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCAGATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTGATCCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCTGCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCAGTCGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTGCCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCACCTATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAAGTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACCCAGCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTCCTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTCTGAACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGTGCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTATGTAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGTGGGTGGTGAGTTCTGACTAAAGGTTACCTGTTGTCGTGA SEQ ID NO:76
激肽释放酶10,转录物变体2
>gi|22208983|ref|NM_145888.1|人类激肽释放酶10(KLK10),转录物变体2,mRNA|qPCR正向引物匹配[714..737]|qPCR反向引物匹配[813..794]|qPCR探针匹配[753..777]
ACCAGCGGCAGACCACAGGCAGGGCAGAGGCACGTCTGGGTCCCCTCCCTCCTTCCTATCGGCGACTCCCAGGATCCTGGCCATGAGAGCTCCGCACCTCCACCTCTCCGCCGCCTCTGGCGCCCGGGCTCTGGCGAAGCTGCTGCCGCTGCTGATGGCGCAACTCTGGGCCGCAGAGGCGGCGCTGCTCCCCCAAAACGACACGCGCTTGGACCCCGAAGCCTATGGCTCCCCGTGCGCGCGCGGCTCGCAGCCCTGGCAGGTCTCGCTCTTCAACGGCCTCTCGTTCCACTGCGCGGGTGTCCTGGTGGACCAGAGTTGGGTGCTGACGGCCGCGCACTGCGGAAACAAGCCACTGTGGGCTCGAGTAGGGGATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCGGACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCCCATCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCTGAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCAGCTTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGTTGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGGCCTGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTGTGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGGACTGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGGCCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGTTTACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCAGATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTGATCCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCTGCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCAGTCGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTGCCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCACCTATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAAGTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACCCAGCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTCCTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTCTGAACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGTGCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTATGTAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGTGGGTGGTGAGTTCTGACTAAAGGTTACCTGTTGTCGTGA SEQ ID NO:77
金属蛋白酶组织抑制剂1
>gi|4507508|ref|NM_003254.1|人类金属蛋白酶组织抑制剂1(促红细胞活性剂、胶原酶抑制剂(TIMP1),mRNA|qPCR正向引物匹配[221..241]|qPCR反向引物匹配[359..340]|qPCR探针匹配[251..283]
AGGGGCCTTAGCGTGCCGCATCGCCGAGATCCAGCGCCCAGAGAGACACCAGAGAACCCACCATGGCCCCCTTTGAGCCCCTGGCTTCTGGCATCCTGTTGTTGCTGTGGCTGATAGCCCCCAGCAGGGCCTGCACCTGTGTCCCACCCCACCCACAGACGGCCTTCTGCAATTCCGACCTCGTCATCAGGGCCAAGTTCGTGGGGACACCAGAAGTCAACCAGACCACCTTATACCAGCGTTATGAGATCAAGATGACCAAGATGTATAAAGGGTTCCAAGCCTTAGGGGATGCCGCTGACATCCGGTTCGTCTACACCCCCGCCATGGAGAGTGTCTGCGGATACTTCCACAGGTCCCACAACCGCAGCGAGGAGTTTCTCATTGCTGGAAAACTGCAGGATGGACTCTTGCACATCACTACCTGCAGTTTCGTGGCTCCCTGGAACAGCCTGAGCTTAGCTCAGCGCCGGGGCTTCACCAAGACCTACACTGTTGGCTGTGAGGAATGCACAGTGTTTCCCTGTTTATCCATCCCCTGCAAACTGCAGAGTGGCACTCATTGCTTGTGGACGGACCAGCTCCTCCAAGGCTCTGAAAAGGGCTTCCAGTCCCGTCACCTTGCCTGCCTGCCTCGGGAGCCAGGGCTGTGCACCTGGCAGTCCCTGCGGTCCCAGATAGCCTGAATCCTGCCCGGAGTGGAACTGAAGCCTGCACAGTGTCCACCCTGTTCCCACTCCCATCTTTCTTCCGGACAATGAAATAAAGAGTTACCACCCAGC
SEQ ID NO:78
富含半胱氨酸的分泌型酸性蛋白质
>gi|48675809|ref|NM_003118.2|人类富含半胱氨酸的分泌型酸性蛋白质(骨粘连蛋白)(SPARC),mRNA |qPCR正向引物匹配[788..810]|qPCR反向引物匹配[915..898]|qPCR探针匹配[818..839]
GTTGCCTGTCTCTAAACCCCTCCACATTCCCGCGGTCCTTCAGACTGCCCGGAGAGCGCGCTCTGCCTGCCGCCTGCCTGCCTGCCACTGAGGGTTCCCAGCACCATGAGGGCCTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGCCCCTCAGCAAGAAGCCCTGCCTGATGAGACAGAGGTGGTGGAAGAAACTGTGGCAGAGGTGACTGAGGTATCTGTGGGAGCTAATCCTGTCCAGGTGGAAGTAGGAGAATTTGATGATGGTGCAGAGGAAACCGAAGAGGAGGTGGTGGCGGAAAATCCCTGCCAGAACCACCACTGCAAACACGGCAAGGTGTGCGAGCTGGATGAGAACAACACCCCCATGTGCGTGTGCCAGGACCCCACCAGCTGCCCAGCCCCCATTGGCGAGTTTGAGAAGGTGTGCAGCAATGACAACAAGACCTTCGACTCTTCCTGCCACTTCTTTGCCACAAAGTGCACCCTGGAGGGCACCAAGAAGGGCCACAAGCTCCACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCTTGCCTGGACTCTGAGCTGACCGAATTCCCCCTGCGCATGCGGGACTGGCTCAAGAACGTCCTGGTCACCCTGTATGAGAGGGATGAGGACAACAACCTTCTGACTGAGAAGCAGAAGCTGCGGGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAACTATAACATGTACATCTTCCCTGTACACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTACCTCTCCCACACCGAGCTGGCTCCACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGGACAATGACAAGTACATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAAATCCACTCCTTCCACAGTACCGGATTCTCTCTTTAACCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGAGACAAGGTGCTAACATAGATTTAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAGACATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTCCACACGCATTAATAGTCCCATTTTTCTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACATGGGTGGACACGGATCTGCTGGGCTCTGCCTTAAACACACATTGCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTACCGAGTCAGACTTTGTGTTCATTTCATTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACAGACACACGATGTTGTCAAGGATGGTTTTGGGACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTGCCTGAGGCTGTAACTGAGAGAAAGATTCTGGGGCTGTGTTATGAAAATATAGACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTTTCACATTAGGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGGGCTTCTCCTCCTCTGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAAATAGAAAAAGTGGAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGATGATTGTCATAAGGTTTTTAGCATGTTCCTCCTTTTCTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATGGTCGGATCTCACAGGCTGAGAACTCGTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATGTGAAGAGTTTCACAAATCCTTCAAAATAAAAAGTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACCTTATTATCCTGACACAAAAACACATGAGCATACATGTCTACACATGACTACACAAATGCAAACCTTTGCAAACACATTATGCTTTTGCACACACACACCTGTACACACACACCGGCATGTTTATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGACCTGTGGTTTAACCCTTTTGATCACTACCACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATTCATTCATTCACAAAATATTTATGATGTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGACAAAGCATTTGTTCATTTGGAGCTTAGAGTCCAGGAGGAATACATTAGATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATGAAGGGAGAGTAGGAGAGACCATGAGTATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCCACATGTAACTTTTTAAGATTTAAATTTAAATTAGTTAACATTCAAAACGCAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGAGCCATGCATGATTAGTGGTTACCCTATTGAATAGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCTAGATCATCATAAGACTACAGAGCACTTTTCAAAGCTCATGCATGTTCATCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGAGAAACAGACCCAAGAAATGTGCTCAATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATTTTAAGTTATGTTAAGATTACTAAAACAATAAAAGCTCCTAAAAAATCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA SEQ ID NO:79
转化生长因子β诱导蛋白
>gi|4507466|ref|NM_000358.1|人类68kDa的转化生长因子β诱导蛋白(TGFBI),mRNA|qPCR据assay_on_demand情况匹配[170..194]
GCTTGCCCGTCGGTCGCTAGCTCGCTCGGTGCGCGTCGTCCCGCTCCATGGCGCTCTTCGTGCGGCTGCTGGCTCTCGCCCTGGCTCTGGCCCTGGGCCCCGCCGCGACCCTGGCGGGTCCCGCCAAGTCGCCCTACCAGCTGGTGCTGCAGCACAGCAGGCTCCGGGGCCGCCAGCACGGCCCCAACGTGTGTGCTGTGCAGAAGGTTATTGGCACTAATAGGAAGTACTTCACCAACTGCAAGCAGTGGTACCAAAGGAAAATCTGTGGCAAATCAACAGTCATCAGCTACGAGTGCTGTCCTGGATATGAAAAGGTCCCTGGGGAGAAGGGCTGTCCAGCAGCCCTACCACTCTCAAACCTTTACGAGACCCTGGGAGTCGTTGGATCCACCACCACTCAGCTGTACACGGACCGCACGGAGAAGCTGAGGCCTGAGATGGAGGGGCCCGGCAGCTTCACCATCTTCGCCCCTAGCAACGAGGCCTGGGCCTCCTTGCCAGCTGAAGTGCTGGACTCCCTGGTCAGCAATGTCAACATTGAGCTGCTCAATGCCCTCCGCTACCATATGGTGGGCAGGCGAGTCCTGACTGATGAGCTGAAACACGGCATGACCCTCACCTCTATGTACCAGAATTCCAACATCCAGATCCACCACTATCCTAATGGGATTGTAACTGTGAACTGTGCCCGGCTCCTGAAAGCCGACCACCATGCAACCAACGGGGTGGTGCACCTCATCGATAAGGTCATCTCCACCATCACCAACAACATCCAGCAGATCATTGAGATCGAGGACACCTTTGAGACCCTTCGGGCTGCTGTGGCTGCATCAGGGCTCAACACGATGCTTGAAGGTAACGGCCAGTACACGCTTTTGGCCCCGACCAATGAGGCCTTCGAGAAGATCCCTAGTGAGACTTTGAACCGTATCCTGGGCGACCCAGAAGCCCTGAGAGACCTGCTGAACAACCACATCTTGAAGTCAGCTATGTGTGCTGAAGCCATCGTTGCGGGGCTGTCTGTAGAGACCCTGGAGGGCACGACACTGGAGGTGGGCTGCAGCGGGGACATGCTCACTATCAACGGGAAGGCGATCATCTCCAATAAAGACATCCTAGCCACCAACGGGGTGATCCACTACATTGATGAGCTACTCATCCCAGACTCAGCCAAGACACTATTTGAATTGGCTGCAGAGTCTGATGTGTCCACAGCCATTGACCTTTTCAGACAAGCCGGCCTCGGCAATCATCTCTCTGGAAGTGAGCGGTTGACCCTCCTGGCTCCCCTGAATTCTGTATTCAAAGATGGAACCCCTCCAATTGATGCCCATACAAGGAATTTGCTTCGGAACCACATAATTAAAGACCAGCTGGCCTCTAAGTATCTGTACCATGGACAGACCCTGGAAACTCTGGGCGGCAAAAAACTGAGAGTTTTTGTTTATCGTAATAGCCTCTGCATTGAGAACAGCTGCATCGCGGCCCACGACAAGAGGGGGAGGTACGGGACCCTGTTCACGATGGACCGGGTGCTGACCCCCCCAATGGGGACTGTCATGGATGTCCTGAAGGGAGACAATCGCTTTAGCATGCTGGTAGCTGCCATCCAGTCTGCAGGACTGACGGAGACCCTCAACCGGGAAGGAGTCTACACAGTCTTTGCTCCCACAAATGAAGCCTTCCGAGCCCTGCCACCAAGAGAACGGAGCAGACTCTTGGGAGATGCCAAGGAACTTGCCAACATCCTGAAATACCACATTGGTGATGAAATCCTGGTTAGCGGAGGCATCGGGGCCCTGGTGCGGCTAAAGTCTCTCCAAGGTGACAAGCTGGAAGTCAGCTTGAAAAACAATGTGGTGAGTGTCAACAAGGAGCCTGTTGCCGAGCCTGACATCATGGCCACAAATGGCGTGGTCCATGTCATCACCAATGTTCTGCAGCCTCCAGCCAACAGACCTCAGGAAAGAGGGGATGAACTTGCAGACTCTGCGCTTGAGATCTTCAAACAAGCATCAGCGTTTTCCAGGGCTTCCCAGAGGTCTGTGCGACTAGCCCCTGTCTATCAAAAGTTATTAGAGAGGATGAAGCATTAGCTTGAAGCACTACAGGAGGAATGCACCACGGCAGCTCTCCGCCAATTTCTCTCAGATTTCCACAGAGACTGTTTGAATGTTTTCAAAACCAAGTATCACACTTTAATGTACATGGGCCGCACCATAATGAGATGTGAGCCTTGTGCATGTGGGGGAGGAGGGAGAGAGATGTACTTTTTAAATCATGTTCCCCCTAAACATGGCTGTTAACCCACTGCATGCAGAAACTTGGATGTCACTGCCTGACATTCACTTCCAGAGAGGACCTATCCCAAATGTGGAATTGACTGCCTATGCCAAGTCCCTGGAAAAGGAGCTTCAGTATTGTGGGGCTCATAAAACATGAATCAAGCAATCCAGCCTCATGGGAAGTCCTGGCACAGTTTTTGTAAAGCCCTTGCACAGCTGGAGAAATGGCATCATTATAAGCTATGAGTTGAAATGTTCTGTCAAATGTGTCTCACATCTACACGTGGCTTGGAGGCTTTTATGGGGCCCTGTCCAGGTAGAAAAGAAATGGTATGTAGAGCTTAGATTTCCCTATTGTGACAGAGCCATGGTGTGTTTGTAATAATAAAACCAAAGAAACATA SEQ ID NO:80
包含EGF的纤蛋白样细胞外基质蛋白质2
>gi|8393298|ref|NM_016938.1|人类包含EGF的纤蛋白样细胞外基质蛋白质2(EFEMP2),mRNA|qPCR据assay_on_demand情况匹配[1248..1272]
CAAGCTTGGCACGAGGGCAGGCATTGCCCGAGCCAGCCGAGCCGCCAGAGCCGCGGGCCGCGCGGGTGTCGCGGGCCCAACCCCAGGATGCTCCCCTGCGCCTCCTGCCTACCCGGGTCTCTACTGCTCTGGGCGCTGCTACTGTTGCTCTTGGGATCAGCTTCTCCTCAGGATTCTGAAGAGCCCGACAGCTACACGGAATGCACAGATGGCTATGAGTGGGACCCAGACAGCCAGCACTGCCGGGATGTCAACGAGTGTCTGACCATCCCTGAGGCCTGCAAGGGGGAAATGAAGTGCATCAACCACTACGGGGGCTACTTGTGCCTGCCCCGCTCCGCTGCCGTCATCAACGACCTACACGGCGAGGGACCCCCGCCACCAGTGCCTCCCGCTCAACACCCCAACCCCTGCCCACCAGGCTATGAGCCCGACGATCAGGACAGCTGTGTGGATGTGGACGAGTGTGCCCAGGCCCTGCACGACTGTCGCCCCAGCCAGGACTGCCATAACTTGCCTGGCTCCTATCAGTGCACCTGCCCTGATGGTTACCGCAAGATCGGGCCCGAGTGTGTGGACATAGACGAGTGCCGCTACCGCTACTGCCAGCACCGCTGCGTGAACCTGCCTGGCTCCTTCCGCTGCCAGTGCGAGCCGGGCTTCCAGCTGGGGCCTAACAACCGCTCCTGTGTTGATGTGAACGAGTGTGACATGGGGGCCCCATGCGAGCAGCGCTGCTTCAACTCCTATGGGACCTTCCTGTGTCGCTGCCACCAGGGCTATGAGCTGCATCGGGATGGCTTCTCCTGCAGTGATATTGATGAGTGTAGCTACTCCAGCTACCTCTGTCAGTACCGCTGCGTCAACGAGCCAGGCCGTTTCTCCTGCCACTGCCCACAGGGTTACCAGCTGCTGGCCACACGCCTCTGCCAAGACATTGATGAGTGTGAGTCTGGTGCGCACCAGTGCTCCGAGGCCCAAACCTGTGTCAACTTCCATGGGGGCTACCGCTGCGTGGACACCAACCGCTGCGTGGAGCCCTACATCCAGGTCTCTGAGAACCGCTGTCTCTGCCCGGCCTCCAACCCTCTATGTCGAGAGCAGCCTTCATCCATTGTGCACCGCTACATGACCATCACCTCGGAGCGGAGAGTACCCGCTGACGTGTTCCAGATCCAGGCGACCTCCGTCTACCCCGGTGCCTACAATGCCTTTCAGATCCGTGCTGGAAACTCGCAGGGGGACTTTTACATTAGGCAAATCAACAACGTCAGCGCCATGCTGGTCCTCGCCCGGCCGGTGACGGGCCCCCGGGAGTACGTGCTGGACCTGGAGATGGTCACCATGAATTCCCTCATGAGCTACCGGGCCAGCTCTGTACTGAGGCTCACCGTCTTTGTAGGGGCCTACACCTTCTGAGGAGCAGGAGGGAGCCACCCTCCCTGCAGCTACCCTAGCTGAGGAGCCTGTTGTGAGGGGCAGAATGAGAAAGGCCCAGGGGCCCCCATTGACAGGAGCTGGGAGCTCTGCACCACGAGCTTCAGTCACCCCGAGAGGAGAGGAGGTAACGAGGAGGGCGGACTCCAGGCCCCGGCCCAGAGATTTGGACTTGGCTGGCTTGCAGGGGTCCTAAGAAACTCCACTCTGGACAGCGCCAGGAGGCCCTGGGTTCCATTCCTAACTCTGCCTCAAACTGTACATTTGGATAAGCCCTAGTAGTTCCCTGGGCCTGTTTTTCTATAAAACGAGGCAACTGG SEQ ID NO:81
光亮蛋白聚糖
>gi|21359858|ref|NM_002345.2|人类光亮蛋白聚糖(LUM),mRNA|qPCR正向引物匹配[61..84]|qPCR反向引物匹配[182..162]|qPCR探针匹配[117..152]
GTATCACTCAGAATCTGGCAGCCAGTTCCGTCCTGACAGAGTTCACAGCATATATTGGTGGATTCTTGTCCATAGTGCATCTGCTTTAAGAATTAACGAAAGCAGTGTCAAGACAGTAAGGATTCAAACCATTTGCCAAAAATGAGTCTAAGTGCATTTACTCTCTTCCTGGCATTGATTGGTGGTACCAGTGGCCAGTACTATGATTATGATTTTCCCCTATCAATTTATGGGCAATCATCACCAAACTGTGCACCAGAATGTAACTGCCCTGAAAGCTACCCAAGTGCCATGTACTGTGATGAGCTGAAATTGAAAAGTGTACCAATGGTGCCTCCTGGAATCAAGTATCTTTACCTTAGGAATAACCAGATTGACCATATTGATGAAAAGGCCTTTGAGAATGTAACTGATCTGCAGTGGCTCATTCTAGATCACAACCTTCTAGAAAACTCCAAGATAAAAGGGAGAGTTTTCTCTAAATTGAAACAACTGAAGAAGCTGCATATAAACCACAACAACCTGACAGAGTCTGTGGGCCCACTTCCCAAATCTCTGGAGGATCTGCAGCTTACTCATAACAAGATCACAAAGCTGGGCTCTTTTGAAGGATTGGTAAACCTGACCTTCATCCATCTCCAGCACAATCGGCTGAAAGAGGATGCTGTTTCAGCTGCTTTTAAAGGTCTTAAATCACTCGAATACCTTGACTTGAGCTTCAATCAGATAGCCAGACTGCCTTCTGGTCTCCCTGTCTCTCTTCTAACTCTCTACTTAGACAACAATAAGATCAGCAACATCCCTGATGAGTATTTCAAGCGTTTTAATGCATTGCAGTATCTGCGTTTATCTCACAACGAACTGGCTGATAGTGGAATACCTGGAAATTCTTTCAATGTGTCATCCCTGGTTGAGCTGGATCTGTCCTATAACAAGCTTAAAAACATACCAACTGTCAATGAAAACCTTGAAAACTATTACCTGGAGGTCAATCAACTTGAGAAGTTTGACATAAAGAGCTTCTGCAAGATCCTGGGGCCATTATCCTACTCCAAGATCAAGCATTTGCGTTTGGATGGCAATCGCATCTCAGAAACCAGTCTTCCACCGGATATGTATGAATGTCTACGTGTTGCTAACGAAGTCACTCTTAATTAATATCTGTATCCTGGAACAATATTTTATGGTTATGTTTTTCTGTGTGTCAGTTTTCATAGTATCCATATTTTATTACTGTTTATTACTTCCATGAATTTTAAAATCTGAGGGAAATGTTTTGTAAACATTTATTTTTTTTAAAGAAAAGATGAAAGGCAGGCCTATTTCATCACAAGAACACACACATATACACGAATAGACATCAAACTCAATGCTTTATTTGTAAATTTAGTGTTTTTTTATTTCTACTGTCAAATGATGTGCAAAACCTTTTACTGGTTGCATGGAAATCAGCCAAGTTTTATAATCCTTAAATCTTAATGTTCCTCAAAGCTTGGATTAAATACATATGGATGTTACTCTCTTGCACCAAATTATCTTGATACATTCAAATTTGTCTGGTTAAAAAATAGGTGGTAGATATTGAGGCCAAGAATATTGCAAAATACATGAAGCTTCATGCACTTAAAGAAGTATTTTTAGAATAAGAATTTGCATACTTACCTAGTGAAACTTTTCTAGAATTATTTTTCACTCTAAGTCATGTATGTTTCTCTTTGATTATTTGCATGTTATGTTTAATAAGCTACTAGCAAAATAAAACATAGCAAATGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA SE QID NO:82
Stannin
>gi|29893560|ref|NM_003498.3|人类stannin(SNN),mRNA
AGCGGGGCCGGACCGGGCGGGCGGAGCCGGGCCCGCGGGGCTGCTGCGGGGCGATCGGGCCGGGCCGCTGCCGCGCCATGGACTCCCGTGTCCAGCCTGAGTTCCAGCCTCACTGAGTGGCCACCCCCAAAGTGCTGCCAGCCGAGGAAGCCCCCAGCACTGACCATGTCTATTATGGACCACAGCCCCACCACGGGCGTGGTCACAGTCATCGTCATCCTCATTGCCATCGCGGCCCTGGGGGCCTTGATCCTGGGCTGCTGGTGCTACCTGCGGCTGCAGCGCATCAGCCAGTCAGAGGACGAGGAGAGCATCGTGGGGGATGGGGAGACCAAGGAACCCTTCCTGCTGGTGCAGTATTCGGCCAAGGGACCGTGCGTGGAGAGAAAGGCCAAGCTGATGACTCCCAACGGCCCGGAAGTCCACGGCTGAGCCAGGATGCAAGGCTCCTGGTCCTGTTTGCAGCCGGCCAAGAGGCGCTGGGAGGGGCAAAACCATACGGATGCGCTGCTGTCTGAGAGGAAGGGCTGACACTTGCTGGCATGGCCTCTGCGGGCTTCGTCATCGCATGCACTGATGCCCGGGGACCTGGCTGTCCTGGGCTTCCCCTCGGCCTCCAGGTGAGGCTGCCCATTGCAGGCACTGGGCAGGCCTGACCTTGCTGGGGCTCATGGCCCTGTAGCGCTTTTGTTACTTGAATGTCTAGCTGAGCCTGTTTTTGATGGAGCTACTACTGTAATGCGTGAACTAACAAACCTGTGAACTGTAAATAGGCCCCTGGAAGCACGTGCTTAAGCCCTTTTGCTGATTTTTAAAAATATCATCTAGCGCACACGGGACTGGTATTCTGGCTGTACTAATGACAAGCTGAGTCAAGACCCTGGAGGGTCATAGGCTTGTAAAGGCCCACGCCACACTCGGCAGGGGTCTCTCATGTGTGTCCATCTGCGTGTATGTCAAGGAAGTGAGATGCCAATTTGGGGTCTTGAGGCTGACCAGTTGGGGTGCTTGGGTGATCTCTGCTTCATTAGTCATGGGTGGAAGAAAAACCACACCCCCCGCACCCCTCCGTTCTTTCTGCATAGACTCACTTGTTAAATAGCAGTTCTGTTGAGAGTGGAGTTACTGCAGGGAAGCTACCGGACCTGCCTGGGAGCCAGTGAAGGGCGAGTCAGGGCACGCGTCCTGGAGGCTGCCAGCGTCCTTGTAGCAGAGCAGTTTCTTGCCGCTTGGGTCTTCAGCACGCCAAGCCCCCCACCAACCCTCCACCCCGAGTGAAGGCTTCGCTGAAATTGCTTTGGTCCTCATAGAGCCTGTGGTGGCTACTTTTGGTCTGAAACCCACTTGGCCCAGGAAAGAGAAAAGGTTGTATGTTTTGTGTTGGTGTTTCCTATTTTCTGCACTGGAGGGGAGGGGACTGTTGAGGTTCTGTCTTTTTTCTTCTTTTCCTCTTCCCTCTTCACATCACTTGGCTTCCTTTCCTCTCTGATGACCGTCCGCCTATGGGGTTCTGACTTCACTTTCCTCAGCGGGTCTCCAGTCCCCTGACCCAGCTCTAAAGGCACTTAGGACCCAGGGAACATTTCTCACGTGCACATTCCCCTAAGAGCCACCAGACTGCTTCCTGCCAGCCTGTGCTTGCGGCAGGGAGCCGGGGCAGGGCAGAGGTGAACTTGAAGTTCAGGACTTGACTCTCCCACAGGTGGTGAGCTGGTGGCTCTCTGGTGAGCTAGTGTCTCCACAGCCTGTCTCCAAGGCCTCCCCTATGTACATTTCAGTGAGCTCACTTTGATTTTTAATCCCACCACAAGCACATACTAATTTTATTTATGATTCAAATGTGACTCGTGCCTGCCCATCCCTGTAATAGATGGAAGGTCAGCCCCGGCTTAACCACAGAGCACTGGCCCTTCATGGCTGAGCTCAGAGCTCTGGCCTCCTGCTCAGACTAAAGGCACCTCCTCTGGCCTCACCCAAGCCTCTTCTAAAAACCATGTTGAATGAATCCACGTTCTGGAACCCCGAGGCGGGAGAAGTAGGGAGCTGTTCGTTTAAGCAGCATACACCTAAATTGGGGGTTTAAACATTAAGTAGGAGCTTGGGGTGGAAGAGGGACAGCCGGCTGGGCCACCTGAGCAGAAGGTGGTAATGAAACACCTCAGCTGGGCTCTTGGGAGACCTTAGGAAGCAGGAGAGGCAACACCTCTGGCTACTGATGGTGTGGCAAGTTCAGAAGAGGTGGTGGTGGGGTAGGCGTGATGTCAGCAGAAGCCCTGCAGGCTGGGTGGGCAGGACACGTGGTGGGGGCCACTGAAACCAGGCCTAGGAGGGAGAACAAGTTCCAAAGGTGCCGACTGGAAGAAGGGGGTAAAAGTTTGCTTTGGTGAGTGAGAAAAGGCTGGGGCGTGTGATCCATCCCCTCACGTTTCAGAACTTCCAGGCTTTCTACCTCGACTCTCACCACAGCCAGCACATACACCTAGGCTGTTTTTCCTTCCTCCACACCTGAGGGACGCAGCAACAGCTAGGATCTGCATTTTCAGGTTCCGAGCCTGACCCCTGGAACTGACCAGCGCTCGATTGTCAGCCTTGGCCTGGGGTTTTGACCTTGCCAGTGAAGTTTCGGTTTTGAAGTGATTAAATGTCACTTCCTCATCAGTTTCACTTCTGGAGGTTTTCTTATCCTACTCCCTGGTGCCAGGGACGTACCTGGGAGTTTGAATCAGGCCCATTTGAGCGTGGCAGCCGTGTTGGGTGAAGGTCCGGGGCTCGGTGAGGCACTGGGGGGGTTTTCGGGAGGAAAATGAAAATGCTTCTAGAATGAGTGAACCACATCATAGCTCTCACTGTTTTTTCAATAGCTACTTTTTTTAGCAGACACCAGAGCCACACTCAAATGGCTAAGTAGGTTATGACCTCTCTGGATTATTTTTGAATGCCCAACTGTTGCATTCAAGTTTTCTGACTAATAAGAAATTAAGCATTCATCCTTCGTATCACTGCAGAAGCAACAGTGGGGGCACAGGGAGGGAACTCTTGACACTGAGCCACTAAAATATGGACTAATTTTTTGGACAAATCTTCAAACGGACTGTGCTACTGTATTTGTCTCAAAGCTACCAAGTTTGTGCAATAAGTGGAAGGGATGTCATCCTTCTTCAATAAATGCTGAATGACATTCAAGCTGATTTTCTAGACCACTGAGAAAATCTTTATTTACAATAAATTTCAATAAAATTTGCATAAATATATTCCCAAAAAAAAAAAAAAAAAAAAAGAAAAAAAAAAAAA SEQ ID NO:83
分泌型磷蛋白1
>gi|38146097|ref|NM_000582.2|人类分泌型磷蛋白1(骨桥蛋白、骨唾液酸蛋白I、早期T-淋巴细胞活化剂1)(SPP1),mRNA|qPCR据assay_on_demand情况匹配[253..277]
CTCCCTGTGTTGGTGGAGGATGTCTGCAGCAGCATTTAAATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGGCATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGCTAAACCCTGACCCATCTCAGAAGCAGAATCTCCTAGCCCCACAGACCCTTCCAAGTAAGTCCAACGAAAGCCATGACCACATGGATGATATGGATGATGAAGATGATGATGACCATGTGGACAGCCAGGACTCCATTGACTCGAACGACTCTGATGATGTAGATGACACTGATGATTCTCACCAGTCTGATGAGTCTCACCATTCTGATGAATCTGATGAACTGGTCACTGATTTTCCCACGGACCTGCCAGCAACCGAAGTTTTCACTCCAGTTGTCCCCACAGTAGACACATATGATGGCCGAGGTGATAGTGTGGTTTATGGACTGAGGTCAAAATCTAAGAAGTTTCGCAGACCTGACATCCAGTACCCTGATGCTACAGACGAGGACATCACCTCACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGCCTTCTGATTGGGACAGCCGTGGGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAGATTATATAAGCGGAAAGCCAATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAATTTCACAGCCATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTGCATCTTCTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACATGAAATGCTTCTTTCTCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTGTAAACTAAAAGCTTCAGGGTTATGTCTATGTTCATTCTATAGAAGAAATGCAAACTATCACTGTATTTTAATATTTGTTATTCTCTCATGAATAGAAATTTATGTAGAAGCAAACAAAATACTTTTACCCACTTAAAAAGAGAATATAACATTTTATGTCACTATAATCTTTTGTTTTTTAAGTTAGTGTATATTTTGTTGTGATTATCTTTTTGTGGTGTGAATAAATCTTTTATCTTGAATGTAATAAGAATTTGGTGGTGTCAATTGCTTATTTGTTTTCCCACGGTTGTCCAGCAATTAATAAAACATAACCTTTTTTACTGCCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA SEQ ID NO:84
硫酸软骨素蛋白聚糖2
>gi|21361115|ref|NM_004385.2|人类硫酸软骨素蛋白聚糖2(多功能蛋白聚糖)(CSPG2),mRNA|qPCR正向引物匹配[10087..10106]|qPCR反向引物匹配[10185..10163]|qPCR探针匹配[10139..10161]
GCTGCCCCGAGCCTTTCTGGGGAAGAACTCCAGGCGTGCGGACGCAACAGCCGAGAACATTAGGTGTTGTGGACAGGAGCTGGGACCAAGATCTTCGGCCAGCCCCGCATCCTCCCGCATCTTCCAGCACCGTCCCGCACCCTCCGCATCCTTCCCCGGGCCACCACGCTTCCTATGTGACCCGCCTGGGCAACGCCGAACCCAGTCGCGCAGCGCTGCAGTGAATTTTCCCCCCAAACTGCAATAAGCCGCCTTCCAAGGCCAAGATGTTCATAAATATAAAGAGCATCTTATGGATGTGTTCAACCTTAATAGTAACCCATGCGCTACATAAAGTCAAAGTGGGAAAAAGCCCACCGGTGAGGGGCTCCCTCTCTGGAAAAGTCAGCCTACCTTGTCATTTTTCAACGATGCCTACTTTGCCACCCAGTTACAACACCAGTGAATTTCTCCGCATCAAATGGTCTAAGATTGAAGTGGACAAAAATGGAAAAGATTTGAAAGAGACTACTGTCCTTGTGGCCCAAAATGGAAATATCAAGATTGGTCAGGACTACAAAGGGAGAGTGTCTGTGCCCACACATCCCGAGGCTGTGGGCGATGCCTCCCTCACTGTGGTCAAGCTGCTGGCAAGTGATGCGGGTCTTTACCGCTGTGACGTCATGTACGGGATTGAAGACACACAAGACACGGTGTCACTGACTGTGGATGGGGTTGTGTTTCACTACAGGGCGGCAACCAGCAGGTACACACTGAATTTTGAGGCTGCTCAGAAGGCTTGTTTGGACGTTGGGGCAGTCATAGCAACTCCAGAGCAGCTCTTTGCTGCCTATGAAGATGGATTTGAGCAGTGTGACGCAGGCTGGCTGGCTGATCAGACTGTCAGATATCCCATCCGGGCTCCCAGAGTAGGCTGTTATGGAGATAAGATGGGAAAGGCAGGAGTCAGGACTTATGGATTCCGTTCTCCCCAGGAAACTTACGATGTGTATTGTTATGTGGATCATCTGGATGGTGATGTGTTCCACCTCACTGTCCCCAGTAAATTCACCTTCGAGGAGGCTGCAAAAGAGTGTGAAAACCAGGATGCCAGGCTGGCAACAGTGGGGGAACTCCAGGCGGCATGGAGGAACGGCTTTGACCAGTGCGATTACGGGTGGCTGTCGGATGCCAGCGTGCGCCACCCTGTGACTGTGGCCAGGGCCCAGTGTGGAGGTGGTCTACTTGGGGTGAGAACCCTGTATCGTTTTGAGAACCAGACAGGCTTCCCTCCCCCTGATAGCAGATTTGATGCCTACTGCTTTAAACCTAAAGAGGCTACAACCATCGATTTGAGTATCCTCGCAGAAACTGCATCACCCAGTTTATCCAAAGAACCACAAATGGTTTCTGATAGAACTACACCAATCATCCCTTTAGTTGATGAATTACCTGTCATTCCAACAGAGTTCCCTCCCGTGGGAAATATTGTCAGTTTTGAACAGAAAGCCACAGTCCAACCTCAGGCTATCACAGATAGTTTAGCCACCAAATTACCCACACCTACTGGCAGTACCAAGAAGCCCTGGGATATGGATGACTACTCACCTTCTGCTTCAGGACCTCTTGGAAAGCTAGACATATCAGAAATTAAGGAAGAAGTGCTCCAGAGTACAACTGGCGTCTCTCATTATGCTACGGATTCATGGGATGGTGTCGTGGAAGATAAACAAACACAAGAATCGGTTACACAGATTGAACAAATAGAAGTGGGTCCTTTGGTAACATCTATGGAAATCTTAAAGCACATTCCTTCCAAGGAATTCCCTGTAACTGAAACACCATTGGTAACTGCAAGAATGATCCTGGAATCCAAAACTGAAAAGAAAATGGTAAGCACTGTTTCTGAATTGGTAACCACAGGTCACTATGGATTCACCTTGGGAGAAGAGGATGATGAAGACAGAACACTTACAGTTGGATCTGATGAGAGCACCTTGATCTTTGACCAAATTCCTGAAGTCATTACGGTGTCAAAGACTTCAGAAGACACCATCCACACTCATTTAGAAGACTTGGAGTCAGTCTCAGCATCCACAACTGTTTCCCCTTTAATTATGCCTGATAATAATGGATCATCCATGGATGACTGGGAAGAGAGACAAACTAGTGGTAGGATAACGGAAGAGTTTCTTGGCAAATATCTGTCTACTACACCTTTTCCATCACAGCATCGTACAGAAATAGAATTGTTTCCTTATTCTGGTGATAAAATATTAGTAGAGGGAATTTCCACAGTTATTTATCCTTCTCTACAAACAGAAATGACACATAGAAGAGAAAGAACAGAAACACTAATACCAGAGATGAGAACAGATACTTATACAGATGAAATACAAGAAGAGATCACTAAAAGTCCATTTATGGGAAAAACAGAAGAAGAAGTCTTCTCTGGGATGAAACTCTCTACATCTCTCTCAGAGCCAATTCATGTTACAGAGTCTTCTGTGGAAATGACCAAGTCTTTTGATTTCCCAACATTGATAACAAAGTTAAGTGCAGAGCCAACAGAAGTAAGAGATATGGAGGAAGACTTTACAGCAACTCCAGGTACTACAAAATATGATGAAAATATTACAACAGTGCTTTTGGCCCATGGTACTTTAAGTGTTGAAGCAGCCACTGTATCAAAATGGTCATGGGATGAAGATAATACAACATCCAAGCCTTTAGAGTCTACAGAACCTTCAGCCTCTTCAAAATTGCCCCCTGCCTTACTCACAACTGTGGGGATGAATGGAAAGGATAAAGACATCCCAAGTTTCACTGAAGATGGAGCAGATGAATTTACTCTTATTCCAGATAGTACTCAAAAGCAGTTAGAGGAGGTTACTGATGAAGACATAGCAGCCCATGGAAAATTCACAATTAGATTTCAGCCAACTACATCAACTGGTATTGCAGAAAAGTCAACTTTGAGAGATTCTACAACTGAAGAAAAAGTTCCACCTATCACAAGCACTGAAGGCCAAGTTTATGCAACCATGGAAGGAAGTGCTTTGGGTGAAGTAGAAGATGTGGACCTCTCTAAGCCAGTATCTACTGTTCCCCAATTTGCACACACTTCAGAGGTGGAAGGATTAGCATTTGTTAGTTATAGTAGCACCCAAGAGCCTACTACTTATGTAGACTCTTCCCATACCATTCCTCTTTCTGTAATTCCCAAGACAGACTGGGGAGTGTTAGTACCTTCTGTTCCATCAGAAGATGAAGTTCTAGGTGAACCCTCTCAAGACATACTTGTCATTGATCAGACTCGCCTTGAAGCGACTATTTCTCCAGAAACTATGAGAACAACAAAAATCACAGAGGGAACAACTCAGGAAGAATTCCCTTGGAAAGAACAGACTGCAGAGAAACCAGTTCCTGCTCTCAGTTCTACAGCTTGGACTCCCAAGGAGGCAGTAACACCACTGGATGAACAAGAGGGCGATGGATCAGCATATACAGTCTCTGAAGATGAATTGTTGACAGGTTCTGAGAGGGTCCCAGTTTTAGAAACAACTCCAGTTGGAAAAATTGATCACAGTGTGTCTTATCCACCAGGTGCTGTAACTGAGCACAAAGTGAAAACAGATGAAGTGGTAACACTAACACCACGCATTGGGCCAAAAGTATCTTTAAGTCCAGGGCCTGAACAAAAATATGAAACAGAAGGTAGTAGTACAACAGGATTTACATCATCTTTGAGTCCTTTTAGTACCCACATTACCCAGCTTATGGAAGAAACCACTACTGAGAAAACATCCCTAGAGGATATTGATTTAGGCTCAGGATTATTTGAAAAGCCCAAAGCCACAGAACTCATAGAATTTTCAACAATCAAAGTCACAGTTCCAAGTGATATTACCACTGCCTTCAGTTCAGTAGACAGACTTCACACAACTTCAGCATTCAAGCCATCTTCCGCGATCACTAAGAAACCACCTCTCATCGACAGGGAACCTGGTGAAGAAACAACCAGTGACATGGTAATCATTGGAGAATCAACATCTCATGTTCCTCCCACTACCCTTGAAGATATTGTAGCCAAGGAAACAGAAACCGATATTGATAGAGAGTATTTCACGACTTCAAGTCCTCCTGCTACACAGCCAACAAGACCACCCACTGTGGAAGACAAAGAGGCCTTTGGACCTCAGGCGCTTTCTACGCCACAGCCCCCAGCAAGCACAAAATTTCACCCTGACATTAATGTTTATATTATTGAGGTCAGAGAAAATAAGACAGGTCGAATGAGTGATTTGAGTGTAATTGGTCATCCAATAGATTCAGAATCTAAAGAAGATGAACCTTGTAGTGAAGAAACAGATCCAGTGCATGATCTAATGGCTGAAATTTTACCTGAATTCCCTGACATAATTGAAATAGACCTATACCACAGTGAAGAAAATGAAGAAGAAGAAGAAGAGTGTGCAAATGCTACTGATGTGACAACCACCCCATCTGTGCAGTACATAAATGGGAAGCATCTCGTTACCACTGTGCCCAAGGACCCAGAAGCTGCAGAAGCTAGGCGTGGCCAGTTTGAAAGTGTTGCACCTTCTCAGAATTTCTCGGACAGCTCTGAAAGTGATACTCATCCATTTGTAATAGCCAAAACGGAATTGTCTACTGCTGTGCAACCTAATGAATCTACAGAAACAACTGAGTCTCTTGAAGTTACATGGAAGCCTGAGACTTACCCTGAAACATCAGAACATTTTTCAGGTGGTGAGCCTGATGTTTTCCCCACAGTCCCATTCCATGAGGAATTTGAAAGTGGAACAGCCAAAAAAGGGGCAGAATCAGTCACAGAGAGAGATACTGAAGTTGGTCATCAGGCACATGAACATACTGAACCTGTATCTCTGTTTCCTGAAGAGTCTTCAGGAGAGATTGCCATTGACCAAGAATCTCAGAAAATAGCCTTTGCAAGGGCTACAGAAGTAACATTTGGTGAAGAGGTAGAAAAAAGTACTTCTGTCACATACACTCCCACTATAGTTCCAAGTTCTGCATCAGCATATGTTTCAGAGGAAGAAGCAGTTACCCTAATAGGAAATCCTTGGCCAGATGACCTGTTGTCTACCAAAGAAAGCTGGGTAGAAGCAACTCCTAGACAAGTTGTAGAGCTCTCAGGGAGTTCTTCGATTCCAATTACAGAAGGCTCTGGAGAAGCAGAAGAAGATGAAGATACAATGTTCACCATGGTAACTGATTTATCACAGAGAAATACTACTGATACACTCATTACTTTAGACACTAGCAGGATAATCACAGAAAGCTTTTTTGAGGTTCCTGCAACCACCATTTATCCAGTTTCTGAACAACCTTCTGCAAAAGTGGTGCCTACCAAGTTTGTAAGTGAAACAGACACTTCTGAGTGGATTTCCAGTACCACTGTTGAGGAAAAGAAAAGGAAGGAGGAGGAGGGAACTACAGGTACGGCTTCTACATTTGAGGTATATTCATCTACACAGAGATCGGATCAATTAATTTTACCCTTTGAATTAGAAAGTCCAAATGTAGCTACATCTAGTGATTCAGGTACCAGGAAAAGTTTTATGTCCTTGACAACACCAACACAGTCTGAAAGGGAAATGACAGATTCTACTCCTGTCTTTACAGAAACAAATACATTAGAAAATTTGGGGGCACAGACCACTGAGCACAGCAGTATCCATCAACCTGGGGTTCAGGAAGGGCTGACCACTCTCCCACGTAGTCCTGCCTCTGTCTTTATGGAGCAGGGCTCTGGAGAAGCTGCTGCCGACCCAGAAACCACCACTGTTTCTTCATTTTCATTAAACGTAGAGTATGCAATTCAAGCCGAAAAGGAAGTAGCTGGCACTTTGTCTCCGCATGTGGAAACTACATTCTCCACTGAGCCAACAGGACTGGTTTTGAGTACAGTAATGGACAGAGTAGTTGCTGAAAATATAACCCAAACATCCAGGGAAATAGTGATTTCAGAGCGATTAGGAGAACCAAATTATGGGGCAGAAATAAGGGGCTTTTCCACAGGTTTTCCTTTGGAGGAAGATTTCAGTGGTGACTTTAGAGAATACTCAACAGTGTCTCATCCCATAGCAAAAGAAGAAACGGTAATGATGGAAGGCTCTGGAGATGCAGCATTTAGGGACACCCAGACTTCACCATCTACAGTACCTACTTCAGTTCACATCAGTCACATATCTGACTCAGAAGGACCCAGTAGCACCATGGTCAGCACTTCAGCCTTCCCCTGGGAAGAGTTTACATCCTCAGCTGAGGGCTCAGGTGAGCAACTGGTCACAGTCAGCAGCTCTGTTGTTCCAGTGCTTCCCAGTGCTGTGCAAAAGTTTTCTGGTACAGCTTCCTCCATTATCGACGAAGGATTGGGAGAAGTGGGTACTGTCAATGAAATTGATAGAAGATCCACCATTTTACCAACAGCAGAAGTGGAAGGTACGAAAGCTCCAGTAGAGAAGGAGGAAGTAAAGGTCAGTGGCACAGTTTCAACAAACTTTCCCCAAACTATAGAGCCAGCCAAATTATGGTCTAGGCAAGAAGTCAACCCTGTAAGACAAGAAATTGAAAGTGAAACAACATCAGAGGAACAAATTCAAGAAGAAAAGTCATTTGAATCCCCTCAAAACTCTCCTGCAACAGAACAAACAATCTTTGATTCACAGACATTTACTGAAACTGAACTCAAAACCACAGATTATTCTGTACTAACAACAAAGAAAACTTACAGTGATGATAAAGAAATGAAGGAGGAAGACACTTCTTTAGTTAACATGTCTACTCCAGATCCAGATGCAAATGGCTTGGAATCTTACACAACTCTCCCTGAAGCTACTGAAAAGTCACATTTTTTCTTAGCTACTGCATTAGTAACTGAATCTATACCAGCTGAACATGTAGTCACAGATTCACCAATCAAAAAGGAAGAAAGTACAAAACATTTTCCGAAAGGCATGAGACCAACAATTCAAGAGTCAGATACTGAGCTCTTATTCTCTGGACTGGGATCAGGAGAAGAAGTTTTACCTACTCTACCAACAGAGTCAGTGAATTTTACTGAAGTGGAACAAATCAATAACACATTATATCCCCACACTTCTCAAGTGGAAAGTACCTCAAGTGACAAAATTGAAGACTTTAACAGAATGGAAAATGTGGCAAAAGAAGTTGGACCACTCGTATCTCAAACAGACATCTTTGAAGGTAGTGGGTCAGTAACCAGCACAACATTAATAGAAATTTTAAGTGACACTGGAGCAGAAGGACCCACGGTGGCACCTCTCCCTTTCTCCACGGACATCGGACATCCTCAAAATCAGACTGTCAGGTGGGCAGAAGAAATCCAGACTAGTAGACCACAAACCATAACTGAACAAGACTCTAACAAGAATTCTTCAACAGCAGAAATTAACGAAACAACAACCTCATCTACTGATTTTCTGGCTAGAGCTTATGGTTTTGAAATGGCCAAAGAATTTGTTACATCAGCACCAAAACCATCTGACTTGTATTATGAACCTTCTGGAGAAGGATCTGGAGAAGTGGATATTGTTGATTCATTTCACACTTCTGCAACTACTCAGGCAACCAGACAAGAAAGCAGCACCACATTTGTTTCTGATGGGTCCCTGGAAAAACATCCTGAGGTGCCAAGCGCTAAAGCTGTTACTGCTGATGGATTCCCAACAGTTTCAGTGATGCTGCCTCTTCATTCAGAGCAGAACAAAAGCTCCCCTGATCCAACTAGCACACTGTCAAATACAGTGTCATATGAGAGGTCCACAGACGGTAGTTTCCAAGACCGTTTCAGGGAATTCGAGGATTCCACCTTAAAACCTAACAGAAAAAAACCCACTGAAAATATTATCATAGACCTGGACAAAGAGGACAAGGATTTAATATTGACAATTACAGAGAGTACCATCCTTGAAATTCTACCTGAGCTGACATCGGATAAAAATACTATCATAGATATTGATCATACTAAACCTGTGTATGAAGACATTCTTGGAATGCAAACAGATATAGATACAGAGGTACCATCAGAACCACATGACAGTAATGATGAAAGTAATGATGACAGCACTCAAGTTCAAGAGATCTATGAGGCAGCTGTCAACCTTTCTTTAACTGAGGAAACATTTGAGGGCTCTGCTGATGTTCTGGCTAGCTACACTCAGGCAACACATGATGAATCAATGACTTATGAAGATAGAAGCCAACTAGATCACATGGGCTTTCACTTCACAACTGGGATCCCTGCTCCTAGCACAGAAACAGAATTAGACGTTTTACTTCCCACGGCAACATCCCTGCCAATTCCTCGTAAGTCTGCCACAGTTATTCCAGAGATTGAAGGAATAAAAGCTGAAGCAAAAGCCCTGGATGACATGTTTGAATCAAGCACTTTGTCTGATGGTCAAGCTATTGCAGACCAAAGTGAAATAATACCAACATTGGGCCAATTTGAAAGGACTCAGGAGGAGTATGAAGACAAAAAACATGCTGGTCCTTCTTTTCAGCCAGAATTCTCTTCAGGAGCTGAGGAGGCATTAGTAGACCATACTCCCTATCTAAGTATTGCTACTACCCACCTTATGGATCAGAGTGTAACAGAGGTGCCTGATGTGATGGAAGGATCCAATCCCCCATATTACACTGATACAACATTAGCAGTTTCAACATTTGCGAAGTTGTCTTCTCAGACACCATCATCTCCCCTCACTATCTACTCAGGCAGTGAAGCCTCTGGACACACAGAGATCCCCCAGCCCAGTGCTCTGCCAGGAATAGACGTCGGCTCATCTGTAATGTCCCCACAGGATTCTTTTAAGGAAATTCATGTAAATATTGAAGCAACTTTCAAACCATCAAGTGAGGAATACCTTCACATAACTGAGCCTCCCTCTTTATCTCCTGACACAAAATTAGAACCTTCAGAAGATGATGGTAAACCTGAGTTATTAGAAGAAATGGAAGCTTCTCCCACAGAACTTATTGCTGTGGAAGGAACTGAGATTCTCCAAGATTTCCAAAACAAAACCGATGGTCAAGTTTCTGGAGAAGCAATCAAGATGTTTCCCACCATTAAAACACCTGAGGCTGGAACTGTTATTACAACTGCCGATGAAATTGAATTAGAAGGTGCTACACAGTGGCCACACTCTACTTCTGCTTCTGCCACCTATGGGGTCGAGGCAGGTGTGGTGCCTTGGCTAAGTCCACAGACTTCTGAGAGGCCCACGCTTTCTTCTTCTCCAGAAATAAACCCTGAAACTCAAGCAGCTTTAATCAGAGGGCAGGATTCCACGATAGCAGCATCAGAACAGCAAGTGGCAGCGAGAATTCTTGATTCCAATGATCAGGCAACAGTAAACCCTGTGGAATTTAATACTGAGGTTGCAACACCACCATTTTCCCTTCTGGAGACTTCTAATGAAACAGATTTCCTGATTGGCATTAATGAAGAGTCAGTGGAAGGCACGGCAATCTATTTACCAGGACCTGATCGCTGCAAAATGAACCCGTGCCTTAACGGAGGCACCTGTTATCCTACTGAAACTTCCTACGTATGCACCTGTGTGCCAGGATACAGCGGAGACCAGTGTGAACTTGATTTTGATGAATGTCACTCTAATCCCTGTCGTAATGGAGCCACTTGTGTTGATGGTTTTAACACATTCAGGTGCCTCTGCCTTCCAAGTTATGTTGGTGCACTTTGTGAGCAAGATACCGAGACATGTGACTATGGCTGGCACAAATTCCAAGGGCAGTGCTACAAATACTTTGCCCATCGACGCACATGGGATGCAGCTGAACGGGAATGCCGTCTGCAGGGTGCCCATCTCACAAGCATCCTGTCTCACGAAGAACAAATGTTTGTTAATCGTGTGGGCCATGATTATCAGTGGATAGGCCTCAATGACAAGATGTTTGAGCATGACTTCCGTTGGACTGATGGCAGCACACTGCAATACGAGAATTGGAGACCCAACCAGCCAGACAGCTTCTTTTCTGCTGGAGAAGACTGTGTTGTAATCATTTGGCATGAGAATGGCCAGTGGAATGATGTTCCCTGCAATTACCATCTCACCTATACGTGCAAGAAAGGAACAGTTGCTTGCGGCCAGCCCCCTGTTGTAGAAAATGCCAAGACCTTTGGAAAGATGAAACCTCGTTATGAAATCAACTCCCTGATTAGATACCACTGCAAAGATGGTTTCATTCAACGTCACCTTCCAACTATCCGGTGCTTAGGAAATGGAAGATGGGCTATACCTAAAATTACCTGCATGAACCCATCTGCATACCAAAGGACTTATTCTATGAAATACTTTAAAAATTCCTCATCAGCAAAGGACAATTCAATAAATACATCCAAACATGATCATCGTTGGAGCCGGAGGTGGCAGGAGTCGAGGCGCTGATCCCTAAAATGGCGAACATGTGTTTTCATCATTTCAGCCAAAGTCCTAACTTCCTGTGCCTTTCCTATCACCTCGAGAAGTAATTATCAGTTGGTTTGGATTTTTGGACCACCGTTCAGTCATTTTGGGTTGCCGTGCTCCCAAAACATTTTAAATGAAAGTATTGGCATTCAAAAAGACAGCAGACAAAATGAAAGAAAATGAGAGCAGAAAGTAAGCATTTCCAGCCTATCTAATTTCTTTAGTTTTCTATTTGCCTCCAGTGCAGTCCATTTCCTAATGTATACCAGCCTACTGTACTATTTAAAATGCTCAATTTCAGCACCGATGGCCATGTAAATAAGATGATTTAATGTTGATTTTAATCCTGTATATAAAATAAAAAGTCACAATGAGTTTGGGCATATTTAATGATGATTATGGAGCCTTAGAGGTCTTTAATCATTGGTTCGGCTGCTTTTATGTAGTTTAGGCTGGAAATGGTTTCACTTGCTCTTTGACTGTCAGCAAGACTGAAGATGGCTTTTCCTGGACAGCTAGAAAACACAAAATCTTGTAGGTCATTGCACCTATCTCAGCCATAGGTGCAGTTTGCTTCTACATGATGCTAAAGGCTGCGAATGGGATCCTGATGGAACTAAGGACTCCAATGTCGAACTCTTCTTTGCTGCATTCCTTTTTCTTCACTTACAAGAAAGGCCTGAATGGAGGACTTTTCTGTAACCAGG SEQ ID NO:85
N-酰基鞘氨醇酰胺水解酶1
>gi|30089929|ref|NM_004315.2|人类N-酰基鞘氨醇酰胺水解酶(酸性神经酰胺酶)1(ASAH1),转录物变体2,mRNA|qPCR正向引物匹配[1212..1228]|qPCR反向引物匹配[1290..1266]|qPCR探针匹配[1233..1260]
GGACTTTGAAATCCAACCCGGTCACCTACCCGCGCGACTGTGTCCACGGATGGCACGAAAGCCAAGCGAGTCCCCCTGCCGAGCTACTCGCGTCCGCCTCCTCCCAAGCTGAGCTCTGCTCCGCCCACCTGAGTCCTTCGCCAGTTAGGAGGAAACACAGCCGCTTAATGAACTGCTGCATCGGGCTGGGAGAGAAAGCTCGCGGGTCCCACCGGGCCTCCTACCCAAGTCTCAGCGCGCTTTTCACCGAGGCCTCAATTCTGGGATTTGGCAGCTTTGCTGTGAAAGCCCAATGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCAGTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAATGCTAAAGGTTATAGTGAATTCTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAGTTATGCAGGTGGTGGATGAAAAATTGCCTGGCCTACTTGGCAACTTTCCTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATATACCTTTAGGAGAGATTATTTCATTCAATATTTTTTATGAATTATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTCATCTAATACATGGGAGAAACATGGATTTTGGAGTATTTCTTGGGTGGAACATAAATAATGATACCTGGGTCATAACTGAGCAACTAAAACCTTTAACAGTGAATTTGGATTTCCAAAGAAACAACAAAACTGTCTTCAAGGCTTCAAGCTTTGCTGGCTATGTGGGCATGTTAACAGGATTCAAACCAGGACTGTTCAGTCTTACACTGAATGAACGTTTCAGTATAAATGGTGGTTATCTGGGTATTCTAGAATGGATTCTGGGAAAGAAAGATGCCATGTGGATAGGGTTCCTCACTAGAACAGTTCTGGAAAATAGCACAAGTTATGAAGAAGCCAAGAATTTATTGACCAAGACCAAGATATTGGCCCCAGCCTACTTTATCCTGGGAGGCAACCAGTCTGGGGAAGGTTGTGTGATTACACGAGACAGAAAGGAATCATTGGATGTATATGAACTCGATGCTAAGCAGGGTAGATGGTATGTGGTACAAACAAATTATGACCGTTGGAAACATCCCTTCTTCCTTGATGATCGCAGAACGCCTGCAAAGATGTGTCTGAACCGCACCAGCCAAGAGAATATCTCATTTGAAACCATGTATGATGTCCTGTCAACAAAACCTGTCCTCAACAAGCTGACCGTATACACAACCTTGATAGATGTTACCAAAGGTCAATTCGAAACTTACCTGCGGGACTGCCCTGACCCTTGTATAGGTTGGTGAGCACACGTCTGGCCTACAGAATGCGGCCTCTGAGACATGAAGACACCATCTCCATGTGACCGAACACTGCAGCTGTCTGACCTTCCAAAGACTAAGACTCGCGGCAGGTTCTCTTTGAGTCAAAAGCTTGTCTTCGTCCATCTGTTGACAAATGACAGACCTTTTTTTTTCCCCCATCAGTTGATTTTTCTTATTTACAGATAACTTCTTTAGGGGAAGTAAAACAGTCATCTAGAATTCACTGAGTTTTGTTTCACTTTGACATTTGGGGATCTGGTGGGCAGTCGAACCATGGTGAACTCCACCTCCGTGGAATAAATGGAGATTCAGCGTGGGTGTTGAATCCAGCACGTCTGTGTGAGTAACGGGACAGTAAACACTCCACATTCTTCAGTTTTTCACTTCTACCTACATATTTGTATGTTTTTCTGTATAACAGCCTTTTCCTTCTGGTTCTAACTGCTGTTAAAATTAATATATCATTATCTTTGCTGTTATTGACAGCGATATAATTTTATTACATATGATTAGAGGGATGAGACAGACATTCACCTGTATATTTCTTTTAATGGGCACAAAATGGGCCCTTGCCTCTAAATAGCACTTTTTGGGGTTCAAGAAGTAATCAGTATGCAAAGCAATCTTTTATACAATAATTGAAGTGTTCCCTTTTTCATAATTACTGTACTTCCCAGTAACCCTAAGGAAGTTGCTAACTTAAAAAACTGCATCCCACGTTCTGTTAATTTAGTAAATAAACAAGTCAAAGACTTGTGGAAAATAGGAAGTGAACCCATATTTTAAATTCTCATAAGTAGCATTCATGTAATAAACAGGTTTTTAGTTTGTTCTTCAGATTGATAGGGAGTTTTAAAGAAATTTTAGTAGTTACTAAAATTATGTTACTGTATTTTTCAGAAATCAAACTGCTTATGAAAAGTACTAATAGAACTTGTTAACCTTTCTAACCTTCACGATTAACTGTGAAATGTACGTCATTTGTGCAAGACCGTTTGTCCACTTCATTTTGTATAATCACAGTTGTGTTCCTGACACTCAATAAACAGTCATTGGAAAGAGTGCCAGTCAGCAGTCATGCA SEQ ID NO:86
N-酰基鞘氨醇酰胺水解酶1转录物变体1
>gi|30089927|ref|NM_177924.1|人类N-酰基鞘氨醇酰胺水解酶(酸性神经酰胺酶)1(ASAH1),转录物变体1,mRNA |qPCR正向引物匹配[1050..1066]|qPCR反向引物匹配[1128..1104]|qPCR探针匹配[1071..1098]
GGCTCTTCTTTGCCTCTGCTGGAGTCCGGGGAGTGGCGTTGGCTGCTAGAGCGATGCCGGGCCGGAGTTGCGTCGCCTTAGTCCTCCTGGCTGCCGCCGTCAGCTGTGCCGTCGCGCAGCACGCGCCGCCGTGGACAGAGGACTGCAGAAAATCAACCTATCCTCCTTCAGGACCAACGTACAGAGGTGCAGTTCCATGGTACACCATAAATCTTGACTTACCACCCTACAAAAGATGGCATGAATTGATGCTTGACAAGGCACCAATGCTAAAGGTTATAGTGAATTCTCTGAAGAATATGATAAATACATTCGTGCCAAGTGGAAAAGTTATGCAGGTGGTGGATGAAAAATTGCCTGGCCTACTTGGCAACTTTCCTGGCCCTTTTGAAGAGGAAATGAAGGGTATTGCCGCTGTTACTGATATACCTTTAGGAGAGATTATTTCATTCAATATTTTTTATGAATTATTTACCATTTGTACTTCAATAGTAGCAGAAGACAAAAAAGGTCATCTAATACATGGGAGAAACATGGATTTTGGAGTATTTCTTGGGTGGAACATAAATAATGATACCTGGGTCATAACTGAGCAACTAAAACCTTTAACAGTGAATTTGGATTTCCAAAGAAACAACAAAACTGTCTTCAAGGCTTCAAGCTTTGCTGGCTATGTGGGCATGTTAACAGGATTCAAACCAGGACTGTTCAGTCTTACACTGAATGAACGTTTCAGTATAAATGGTGGTTATCTGGGTATTCTAGAATGGATTCTGGGAAAGAAAGATGCCATGTGGATAGGGTTCCTCACTAGAACAGTTCTGGAAAATAGCACAAGTTATGAAGAAGCCAAGAATTTATTGACCAAGACCAAGATATTGGCCCCAGCCTACTTTATCCTGGGAGGCAACCAGTCTGGGGAAGGTTGTGTGATTACACGAGACAGAAAGGAATCATTGGATGTATATGAACTCGATGCTAAGCAGGGTAGATGGTATGTGGTACAAACAAATTATGACCGTTGGAAACATCCCTTCTTCCTTGATGATCGCAGAACGCCTGCAAAGATGTGTCTGAACCGCACCAGCCAAGAGAATATCTCATTTGAAACCATGTATGATGTCCTGTCAACAAAACCTGTCCTCAACAAGCTGACCGTATACACAACCTTGATAGATGTTACCAAAGGTCAATTCGAAACTTACCTGCGGGACTGCCCTGACCCTTGTATAGGTTGGTGAGCACACGTCTGGCCTACAGAATGCGGCCTCTGAGACATGAAGACACCATCTCCATGTGACCGAACACTGCAGCTGTCTGACCTTCCAAAGACTAAGACTCGCGGCAGGTTCTCTTTGAGTCAAAAGCTTGTCTTCGTCCATCTGTTGACAAATGACAGACCTTTTTTTTTCCCCCATCAGTTGATTTTTCTTATTTACAGATAACTTCTTTAGGGGAAGTAAAACAGTCATCTAGAATTCACTGAGTTTTGTTTCACTTTGACATTTGGGGATCTGGTGGGCAGTCGAACCATGGTGAACTCCACCTCCGTGGAATAAATGGAGATTCAGCGTGGGTGTTGAATCCAGCACGTCTGTGTGAGTAACGGGACAGTAAACACTCCACATTCTTCAGTTTTTCACTTCTACCTACATATTTGTATGTTTTTCTGTATAACAGCCTTTTCCTTCTGGTTCTAACTGCTGTTAAAATTAATATATCATTATCTTTGCTGTTATTGACAGCGATATAATTTTATTACATATGATTAGAGGGATGAGACAGACATTCACCTGTATATTTCTTTTAATGGGCACAAAATGGGCCCTTGCCTCTAAATAGCACTTTTTGGGGTTCAAGAAGTAATCAGTATGCAAAGCAATCTTTTATACAATAATTGAAGTGTTCCCTTTTTCATAATTACTGTACTTCCCAGTAACCCTAAGGAAGTTGCTAACTTAAAAAACTGCATCCCACGTTCTGTTAATTTAGTAAATAAACAAGTCAAAGACTTGTGGAAAATAGGAAGTGAACCCATATTTTAAATTCTCATAAGTAGCATTCATGTAATAAACAGGTTTTTAGTTTGTTCTTCAGATTGATAGGGAGTTTTAAAGAAATTTTAGTAGTTACTAAAATTATGTTACTGTATTTTTCAGAAATCAAACTGCTTATGAAAAGTACTAATAGAACTTGTTAACCTTTCTAACCTTCACGATTAACTGTGAAATGTACGTCATTTGTGCAAGACCGTTTGTCCACTTCATTTTGTATAATCACAGTTGTGTTCCTGACACTCAATAAACAGTCATTGGAAAGAGTGCCAGTCAGCAGTCATGCA
SEQ ID NO:87
丝氨酸蛋白酶11
>gi|21327712|ref|NM_002775.2|人类丝氨酸蛋白酶11(IGF结合丝氨酸蛋白酶)(PRSS11),mRNA |qPCR正向引物匹配[1030..1048]|qPCR反向引物匹配[1106..1083]|qPCR探针匹配[1080..1050]
CCGGCCCTCGCCCTGTCCGCCGCCACCGCCGCCGCCGCCAGAGTCGCCATGCAGATCCCGCGCGCCGCTCTTCTCCCGCTGCTGCTGCTGCTGCTGGCGGCGCCCGCCTCGGCGCAGCTGTCCCGGGCCGGCCGCTCGGCGCCTTTGGCCGCCGGGTGCCCAGACCGCTGCGAGCCGGCGCGCTGCCCGCCGCAGCCGGAGCACTGCGAGGGCGGCCGGGCCCGGGACGCGTGCGGCTGCTGCGAGGTGTGCGGCGCGCCCGAGGGCGCCGCGTGCGGCCTGCAGGAGGGCCCGTGCGGCGAGGGGCTGCAGTGCGTGGTGCCCTTCGGGGTGCCAGCCTCGGCCACGGTGCGGCGGCGCGCGCAGGCCGGCCTCTGTGTGTGCGCCAGCAGCGAGCCGGTGTGCGGCAGCGACGCCAACACCTACGCCAACCTGTGCCAGCTGCGCGCCGCCAGCCGCCGCTCCGAGAGGCTGCACCGGCCGCCGGTCATCGTCCTGCAGCGCGGAGCCTGCGGCCAAGGGCAGGAAGATCCCAACAGTTTGCGCCATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTGCCGTGGTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAGAGGTGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAGATGGACTGATCGTGACAAATGCCCACGTGGTGACCAACAAGCACCGGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAAATCAAGGATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACCACCAGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAGAGCTGCGGCCGGGAGAGTTCGTGGTCGCCATCGGAAGCCCGTTTTCCCTTCAAAACACAGTCACCACCGGGATCGTGAGCACCACCCAGCGAGGCGGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCCAGACCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGTTAGTAAACCTGGACGGTGAAGTGATTGGAATTAACACTTTGAAAGTGACAGCTGGAATCTCCTTTGCAATCCCATCTGATAAGATTAAAAAGTTCCTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCACCAAGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGTCCAGCAAAGCCAAAGAGCTGAAGGACCGGCACCGGGACTTCCCAGACGTGATCTCAGGAGCGTATATAATTGAAGTAATTCCTGATACCCCAGCAGAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCAATGGACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCATTAAAAGGGAAAGCACCCTGAACATGGTGGTCCGCAGGGGTAATGAAGATATCATGATCACAGTGATTCCCGAAGAAATTGACCCATAGGCAGAGGCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGGATGACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAAGACTTTTGACTGCCATTTTGTTTGTTCAGTGGAGACTCCCTGGCCAACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAAATGTAATGTTGCAGATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCAGTGTGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACAGTCAGCATTTGTCTCCTCCTTTAACTGAGTCATCATCTTAGTCCAACTAATGCAGTCGATACAATGCGTAGATAGAAGAAGCCCCACGGGAGCCAGGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACCCAAAGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGCTTCTCAAACGGCCGAAGTTGCCTCTTTTAGGAATCTCTTTGGAATTGGGAGCACGATGACTCTGAGTTTGAGCTATTAAAGTACTTCTTACACATTG SEQ ID NO:88
分泌型frizzled相关蛋白2
>gi|42656988|ref|NM_050625.4|人类分泌型frizzled相关蛋白2(SFRP2),mRNA|qPCR正向引物匹配[686..703]|qPCR反向引物匹配[750..728]|qPCR探针匹配[705..726]
CCGGGTCGGAGCCCCCCGGAGCTGCGCGCGGGCTTGCAGCGCCTCGCCCGCGCTGTCCTCCCGGTGTCCCGCTTCTCCGCGCCCCAGCCGCCGGCTGCCAGCTTTTCGGGGCCCCGAGTCGCACCCAGCGAAGAGAGCGGGCCCGGGACAAGCTCGAACTCCGGCCGCCTCGCCCTTCCCCGGCTCCGCTCCCTCTGCCCCCTCGGGGTCGCGCGCCCACGATGCTGCAGGGCCCTGGCTCGCTGCTGCTGCTCTTCCTCGCCTCGCACTGCTGCCTGGGCTCGGCGCGCGGGCTCTTCCTCTTTGGCCAGCCCGACTTCTCCTACAAGCGCAGCAATTGCAAGCCCATCCCTGCCAACCTGCAGCTGTGCCACGGCATCGAATACCAGAACATGCGGCTGCCCAACCTGCTGGGCCACGAGACCATGAAGGAGGTGCTGGAGCAGGCCGGCGCTTGGATCCCGCTGGTCATGAAGCAGTGCCACCCGGACACCAAGAAGTTCCTGTGCTCGCTCTTCGCCCCCGTCTGCCTCGATGACCTAGACGAGACCATCCAGCCATGCCACTCGCTCTGCGTGCAGGTGAAGGACCGCTGCGCCCCGGTCATGTCCGCCTTCGGCTTCCCCTGGCCCGACATGCTTGAGTGCGACCGTTTCCCCCAGGACAACGACCTTTGCATCCCCCTCGCTAGCAGCGACCACCTCCTGCCAGCCACCGAGGAAGCTCCAAAGGTATGTGAAGCCTGCAAAAATAAAAATGATGATGACAACGACATAATGGAAACGCTTTGTAAAAATGATTTTGCACTGAAAATAAAAGTGAAGGAGATAACCTACATCAACCGAGATACCAAAATCATCCTGGAGACCAAGAGCAAGACCATTTACAAGCTGAACGGTGTGTCCGAAAGGGACCTGAAGAAATCGGTGCTGTGGCTCAAAGACAGCTTGCAGTGCACCTGTGAGGAGATGAACGACATCAACGCGCCCTATCTGGTCATGGGACAGAAACAGGGTGGGGAGCTGGTGATCACCTCGGTGAAGCGGTGGCAGAAGGGGCAGAGAGAGTTCAAGCGCATCTCCCGCAGCATCCGCAAGCTGCAGTGCTAGTCCCGGCATCCTGATGGCTCCGACAGGCCTGCTCCAGAGCACGGCTGACCATTTCTGCTCCGGGATCTCAGCTCCCGTTCCCCAAGCACACTCCTAGCTGCTCCAGTCTCAGCCTGGGCAGCTTCCCCCTGCCTTTTGCACGTTTGCATCCCCAGCATTTCCTGAGTTATAAGGCCACAGGAGTGGATAGCTGTTTTCACCTAAAGGAAAAGCCCACCCGAATCTTGTAGAAATATTCAAACTAATAAAATCATGAATATTTTTATGAAGTTTAAAAA SEQ ID NO:89
XIIB组磷脂酶A2
>gi|45505134|ref|NM_032562.2|人类XIIB组磷脂酶A2(PLA2G12B),mRNA
TGTCCCTGGAATTCTGGGACACTGGCTGGGGTTTGAGGAGAGAAGCCAGTACCTACCTGGCTGCAGGATGAAGCTGGCCAGTGGCTTCTTGGTTTTGTGGCTCAGCCTTGGGGGTGGCCTGGCTCAGAGCGACACGAGCCCTGACACGGAGGAGTCCTATTCAGACTGGGGCCTTCGGCACCTCCGGGGAAGCTTTGAATCCGTCAATAGCTACTTCGATTCTTTTCTGGAGCTGCTGGGAGGGAAGAATGGAGTCTGTCAGTACAGGTGCCGATATGGAAAGGCACCAATGCCCAGACCTGGCTACAAGCCCCAAGAGCCCAATGGCTGCGGCTCCTATTTCCTGGGTCTCAAGGTACCAGAAAGTATGGACTTGGGCATTCCAGCAATGACAAAGTGCTGCAACCAGCTGGATGTCTGTTATGACACTTGCGGTGCCAACAAATATCGCTGTGATGCAAAATTCCGATGGTGTCTCCACTCGATCTGCTCTGACCTTAAGCGGAGTCTGGGCTTTGTCTCCAAAGTGGAAGCAGCCTGTGATTCCCTGGTTGACACTGTGTTCAACACCGTGTGGACCTTGGGCTGCCGCCCCTTTATGAATAGTCAGCGGGCAGCTTGCATCTGTGCAGAGGAGGAGAAGGAAGAGTTATGAGGAAGAAGTGATTCCTTCCTGGTTTTGAGTGACACCACAGCTGTCAGCCTTCAAGATGTCAAGTCTTCGAGTCAGCGTGACTCATTCATTCTTCCAACAGTTTGGACACCACAAAGCAGGAGAAAGGGAACATTTTTCTACAGCTGGAAAGTGAGTCCTATCCTTTGAGGAAATTTGAAAAAAGACATGGAGTGGTTTGAAAGCTACTCTTCATTTAAGACTGCTCTCCCCAACCAAGACACATTTGCCTGGAAATTCAGTTCTTAGCTTAAAGACTAAAATGCAAGCAAACCCTGCAATTCCTGGACCTGATAGTTATATTCATGAGTGAAATTGTGGGGAGTCCAGCCATTTGGGAGGCAATGACTTTCTGCTGGCCCATGTTTCAGTTGCCAGTAAGCTTCTCACATTTAATAAAGTGTACTTTTTAGAACATT
SEQ ID NO:90
细胞外基质蛋白质Spondin 2
>gi|6912681|ref|NM_012445.1|人类细胞外基质蛋白质spondin 2(SPON2),mRNA
GCACGAGGGAAGAGGGTGATCCGACCCGGGGAAGGTCGCTGGGCAGGGCGAGTTGGGAAAGCGGCAGCCCCCGCCGCCCCCGCAGCCCCTTCTCCTCCTTTCTCCCACGTCCTATCTGCCTCTCGCTGGAGGCCAGGCCGTGCAGCATCGAAGACAGGAGGAACTGGAGCCTCATTGGCCGGCCCGGGGCGCCGGCCTCGGGCTTAAATAGGAGCTCCGGGCTCTGGCTGGGACCCGACCGCTGCCGGCCGCGCTCCCGCTGCTCCTGCCGGGTGATGGAAAACCCCAGCCCGGCCGCCGCCCTGGGCAAGGCCCTCTGCGCTCTCCTCCTGGCCACTCTCGGCGCCGCCGGCCAGCCTCTTGGGGGAGAGTCCATCTGTTCCGCCAGAGCCCCGGCCAAATACAGCATCACCTTCACGGGCAAGTGGAGCCAGACGGCCTTCCCCAAGCAGTACCCCCTGTTCCGCCCCCCTGCGCAGTGGTCTTCGCTGCTGGGGGCCGCGCATAGCTCCGACTACAGCATGTGGAGGAAGAACCAGTACGTCAGTAACGGGCTGCGCGACTTTGCGGAGCGCGGCGAGGCCTGGGCGCTGATGAAGGAGATCGAGGCGGCGGGGGAGGCGCTGCAGAGCGTGCACGCGGTGTTTTCGGCGCCCGCCGTCCCCAGCGGCACCGGGCAGACGTCGGCGGAGCTGGAGGTGCAGCGCAGGCACTCGCTGGTCTCGTTTGTGGTGCGCATCGTGCCCAGCCCCGACTGGTTCGTGGGCGTGGACAGCCTGGACCTGTGCGACGGGGACCGTTGGCGGGAACAGGCGGCGCTGGACCTGTACCCCTACGACGCCGGGACGGACAGCGGCTTCACCTTCTCCTCCCCCAACTTCGCCACCATCCCGCAGGACACGGTGACCGAGATAACGTCCTCCTCTCCCAGCCACCCGGCCAACTCCTTCTACTACCCGCGGCTGAAGGCCCTGCCTCCCATCGCCAGGGTGACACTGGTGCGGCTGCGACAGAGCCCCAGGGCCTTCATCCCTCCCGCCCCAGTCCTGCCCAGCAGGGACAATGAGATTGTAGACAGCGCCTCAGTTCCAGAAACGCCGCTGGACTGCGAGGTCTCCCTGTGGTCGTCCTGGGGACTGTGCGGAGGCCACTGTGGGAGGCTCGGGACCAAGAGCAGGACTCGCTACGTCCGGGTCCAGCCCGCCAACAACGGGAGCCCCTGCCCCGAGCTCGAAGAAGAGGCTGAGTGCGTCCCTGATAACTGCGTCTAAGACCAGAGCCCCGCAGCCCCTGGGGCCCCCGGAGCCATGGGGTGTCGGGGGCTCCTGTGCAGGCTCATGCTGCAGGCGGCCGAGGCACAGGGGGTTTCGCGCTGCTCCTGACCGCGGTGAGGCCGCGCCGACCATCTCTGCACTGAAGGGCCCTCTGGTGGCCGGCACGGGCATTGGGAAACAGCCTCCTCCTTTCCCAACCTTGCTTCTTAGGGGCCCCCGTGTCCCGTCTGCTCTCAGCCTCCTCCTCCTGCAGGATAAAGTCATCCCCAAGGCTCCAGCTACTCTAAATTATGGTCTCCTTATAAGTTATTGCTGCTCCAGGAGATTGTCCTTCATCGTCCAGGGGCCTGGCTCCCACGTGGTTGCAGATACCTCAGACCTGGTGCTCTAGGCTGTGCTGAGCCCACTCTCCCGAGGGCGCATCCAAGCGGGGGCCACTTGAGAAGTGAATAAATGGGGCGGTTTCGGAAGCGTCAGTGTTTCCATGTTATGGATCTCTCTGCGTTTGAATAAAGACTATCTCTGTTGCTCAC SEQ ID NO:91
嗅介蛋白1,转录物变体3
>gi|34335282|ref|NM_058199.2|人类嗅介蛋白1(OLFM1),转录物变体3,mRNA
CCCGCCCCCGCCCCTTCCGAGCAAACTTTTGGCACCCACCGCAGCCCAGCGCGCGTTCGTGCTCCGCAGGGCGCGCCTCTCTCCGCCAATGCCAGGCGCGCGGGGGAGCCATTAGGAGGCGAGGAGAGAGGAGGGCGCAGCTCCCGCCCAGCCCAGCCCTGCCCAGCCCTGCCCGGAGGCAGACGCGCCGGAACCGGGACGCGATAAATATGCAGAGCGGAGGCTTCGCGCAGCAGAGCCCGCGCGCCGCCCGCTCCGGGTGCTGAATCCAGGCGTGGGGACACGAGCCAGGCGCCGCCGCCGGAGCCAGCGGAGCCGGGGCCAGAGCCGGAGCGCGTCCGCGTCCACGCAGCCGCCGGCCGGCCAGCACCCAGGGCCCTGCATGCCAGGTCGTTGGAGGTGGCAGCGAGACATGCACCCGGCCCGGAAGCTCCTCAGCCTCCTCTTCCTCATCCTGATGGGCACTGAACTCACTCAAAATAAAAGAGAAAACAAAGCAGAGAAGATGGGAGGGCCAGAGAGCGAGAGGAAGACCACAGGAGAGAAGACACTGAACGAGCTTCCCTTGTTTTGCCTGGAAGCCCACGCTGGCTCCCTGGCTCTGCCCAGGATGTGCAGTCCAAATCCCAATCCAGCAGTGGGGTTATGTCGTCCCGCTTACCCTCAGAGCCCTTCTCCTGGTGCTGCCCAGACGATCAGCCAGTCCCTCCTGGAGAGGTTCTGCATGGCCTCTAGGAGAGAAGTTTTCTTGGCCCCAGGAAGGCCTGGTGGAGGGTGGTGGTTGTGCACTGTTGCTGGACAGATGCATTCATTCATGTGCACACACACACACACACATGCACACACAGGGGAGCAGATACCTGCAGAGAAGAGCCAACCAGGTCCTGATTAGTGGCAAGCTGCCCCACAAAGGGCTATGCCTGTGTCTTATTGAGACACCTTGGCAAAGAGATGGCTGATTCTGGGTGGTCCTGGACATGGCCGCACCCAAGGGCCCTCCAAGCCTTAATGGCACCCTGAAGCCTCCATGCCCAGGCCAAAAGATGCTTTTCCTCCCTAAAAAAAAAAAAAAAAAAA
SEQ ID NO:92
包含重复的血小板反应蛋白1
>gi|38016903|ref|NM_019032.2|人类包含重复的血小板反应蛋白1(TSRC1),mRNA
GGGGCCCCAGTGGCCGCCGCGGAGCGAGGTTGCCTGGAGAGAGCGCCTGGGCGCAGAAGGGTTAACGGGCCACCGGGGGCTCGCAGAGCAGGAGGGTGCTCTCGGACGGTGTGTCCCCCACTGCACTCCTGAACTTGGAGGACAGGGTCGCCGCGAGGGACGCAGAGAGCACCCTCCACGCCCAGATGCCTGCGTAGTTTTTGTGACCAGTCCGCTCCTGCCTCCCCCTGGGGCAGTAGAGGGGGAGCGATGGAGAACTGGACTGGCAGGCCCTGGCTGTATCTGCTGCTGCTTCTGTCCCTCCCTCAGCTCTGCTTGGATCAGGAGGTGTTGTCCGGACACTCTCTTCAGACACCTACAGAGGAGGGCCAGGGCCCCGAAGGTGTCTGGGGACCTTGGGTCCAGTGGGCCTCTTGCTCCCAGCCCTGCGGGGTGGGGGTGCAGCGCAGGAGCCGGACATGTCAGCTCCCTACAGTGCAGCTCCACCCGAGTCTGCCCCTCCCTCCCCGGCCCCCAAGACATCCAGAAGCCCTCCTCCCCCGGGGCCAGGGTCCCAGACCCCAGACTTCTCCAGAAACCCTCCCCTTGTACAGGACACAGTCTCGGGGAAGGGGTGGCCCACTTCGAGGTCCCGCTTCCCACCTAGGGAGAGAGGAGACCCAGGAGATTCGAGCGGCCAGGAGGTCCCGGCTTCGAGACCCCATCAAGCCAGGAATGTTCGGTTATGGGAGAGTGCCCTTTGCATTGCCACTGCACCGGAACCGCAGGCACCCTCGGAGCCCACCCAGATCTGAGCTGTCCCTGATCTCTTCTAGAGGGGAAGAGGCTATTCCGTCCCCTACTCCAAGAGCAGAGCCATTCTCCGCAAACGGCAGCCCCCAAACTGAGCTCCCTCCCACAGAACTGTCTGTCCACACCCCATCCCCCCAAGCAGAACCTCTAAGCCCTGAAACTGCTCAGACAGAGGTGGCCCCCAGAACCAGGCCTGCCCCCCTACGGCATCACCCCAGAGCCCAGGCCTCTGGCACAGAGCCCCCCTCACCCACGCACTCCTTAGGAGAAGGTGGCTTCTTCCGTGCATCCCCTCAGCCACGAAGGCCAAGTTCCCAGGGTTGGGCCAGTCCCCAG GTAGCAGGGAGACGCCCTGATCCTTTTCCTTCGGTCCCTCGGGGCCGAGGCCAGCAGGGCCAAGGGCCTTGGGGAACGGGGGGGACTCCTCACGGGCCCCGCCTGGAGCCTGACCCTCAGCACCCGGGCGCCTGGCTGCCCCTGCTGAGCAACGGCCCCCATGCCAGCTCCCTCTGGAGCCTCTTTGCTCCCAGTAGCCCTATTCCAAGATGTTCTGGGGAGAGTGAACAGCTAAGAGCCTGCAGCCAAGCGCCCTGCCCCCCTGAGCAGCCAGACCCCCGGGCCCTGCAGTGCGCAGCCTTTAACTCCCAGGAATTCATGGGCCAGCTGTATCAGTGGGAGCCCTTCACTGAAGTCCAGGGCTCCCAGCGCTGTGAACTGAACTGCCGGCCCCGTGGCTTCCGCTTCTATGTCCGTCACACTGAAAAGGTCCAGGATGGGACCCTGTGTCAGCCTGGAGCCCCTGACATCTGTGTGGCTGGAC
GCTGTCTGAGCCCCGGCTGTGATGGGATCCTTGGCTCTGGCAGGCGTCCTGATGGCTGTGGAGTCTGTGGGGGTGATGATTCTACCTGTCGCCTTGTTTCGGGGAACCTCACTGACCGAGGGGGCCCCCTGGGCTATCAGAAGATCTTGTGGATTCCAGCGGGAGCCTTGCGGCTCCAGATTGCCCAGCTCCGGCCTAGCTCCAACTACCTGGCACTTCGTGGCCCTGGGGGCCGGTCCATCATCAATGGGAACTGGGCTGTGGATCCCCCTGGGTCCTACAGGGCCGGCGGGACCGTCTTTCGATATAACCGTCCTCCCAGGGAGGAGGGCAAAGGGGAGAGTCTGTCGGCTGAAGGCCCCACCACCCAGCCTGTGGATGTCTATATGATCTTTCAGGAGGAAAACCCAGGCGTTTTTTATCAGTATGTCATCTCTTCACCTCCTCCAATCCTTGAGAACCCCACCCCAGAGCCCCCTGTCCCCCAGCTTCAGCCGGAGATTCTGAGGGTGGAGCCCCCACTTGCTCCGGCACCCCGCCCAGCCCGGACCCCAGGCACCCTCCAGCGTCAGGTGCGGATCCCCCAGATGCCCGCCCCGCCCCATCCCAGGACACCCCTGGGGTCTCCAGCTGCGTACTGGAAACGAGTGGGACACTCTGCATGCTCAGCGTCCTGCGGGAAAGGTGTCTGGCGCCCCATTTTCCTCTGCATCTCCCGTGAGTCGGGAGAGGAACTGGATGAACGCAGCTGTGCCGCGGGTGCCAGGCCCCCAGCCTCCCCTGAACCCTGCCACGGCACCCCATGCCCCCCATACTGGGAGGCTGGCGAGTGGACATCCTGCAGCCGCTCCTGTGGCCCCGGCACCCAGCACCGCCAGCTGCAGTGCCGGCAGGAATTTGGGGGGGGTGGCTCCTCGGTGCCCCCGGAGCGCTGTGGACATCTCCCCCGGCCCAACATCACCCAGTCTTGCCAGCTGCGCCTCTGTGGCCATTGGGAAGTTGGCTCTCCTTGGAGCCAGTGCTCCGTGCGGTGCGGCCGGGGCCAGAGAAGCCGGCAGGTTCGCTGTGTTGGGAACAACGGTGATGAAGTGAGCGAGCAGGAGTGTGCGTCAGGCCCCCCGCAGCCCCCCAGCAGAGAGGCCTGTGACATGGGGCCCTGTACTACTGCCTGGTTCCACAGCGACTGGAGCTCCAAGTGCTCAGCCGAGTGTGGGACGGGAATCCAGCGGCGCTCTGTGGTCTGCCTTGGGAGTGGGGCAGCCCTCGGGCCAGGCCAGGGGGAAGCAGGAGCAGGAACTGGGCAGAGCTGTCCAACAGGAAGCCGGCCCCCTGACATGCGCGCCTGCAGCCTGGGGCCCTGTGAGAGAACTTGGCGCTGGTACACAGGGCCCTGGGGTGAGTGCTCCTCCGAATGTGGCTCTGGCACACAGCGTAGAGACATCATCTGTGTATCCAAACTGGGGACGGAGTTCAACGTGACTTCTCCGAGCAACTGTTCTCACCTCCCCAGGCCCCCTGCCCTGCAGCCCTGTCAAGGGCAGGCCTGCCAGGACCGATGGTTTTCCACGCCCTGGAGCCCATGTTCTCGCTCCTGCCAAGGGGGAACGCAGACACGGGAGGTCCAGTGCCTGAGCACCAACCAGACCCTCAGCACCCGATGCCCTCCTCAACTGCGGCCCTCCAGGAAGCGCCCCTGTAACAGCCAACCCTGCAGCCAGCGCCCTGATGATCAATGCAAGGACAGCTCTCCACATTGCCCCCTGGTGGTACAGGCCCGGCTCTGCGTCTACCCCTACTACACAGCCACCTGTTGCCGCTCTTGCGCACATGTCCTGGAGCGGTCTCCCCAGGATCCCTCCTGAAAGGGGTCCGGGGCACCTTCACGGTTTTCTGTGCCACCATCGGTCACCCATTGATCGGCCCACTCTGAACCCCCTGGCTCTCCAGCCTGTCCCAGTCTCAGCAGGGATGTCCTCCAGGTGACAGAGGGTGGCAAGGTGACTGACACAAAGTGACTTTCAGGGCTGTGGTCAGGCCCATGTGGTGGTGTGATGGGTGTGTGCACATATGCCTCAGGTGTGCTTTTGGGACTGCATGGATATGTGTGTGCTCAAACGTGTATCACTTTTCAAAAAGAGGTTACACAGACTGAGAAGGACAAGACCTGTTTCCTTGAGACTTTCCTAGGTGGAAAGGAAAGCAAGTCTGCAGTTCCTTGCTAATCTGAGCTACTTAGAGTGTGGTCTCCCCACCAACTCCAGTTTTGTGCCCTAAGCCTCATTTCTCATGTTCAGACCTCACATCTTCTAAGCCGCCCTGTGTCTCTGACCCCTTCTCATTTGCCTAGTATCTCTGCCCCTGCCTCCCTAATTAGCTAGGGCTGGGGTCAGCCACTGCCAATCCTGCCTTACTCAGGAAGGCAGGAGGAAAGAGACTGCCTCTCCAGAGCAAGGCCCAGCTGGGCAGAGGGTGAAAAAGAGAAATGTGAGCATCCGCTCCCCCACCACCCCGCCCAGCCCCTAGCCCCACTCCCTGCCTCCTGAAATGGTTCCCACCCAGAACTAATTTATTTTTTATTAAAGATGGTCATGACAAATGAAAAAAAAAAAAAAAAAAA
SEQ ID NO:93
血小板反应蛋白2
>gi|40317627|ref|NM_003247.2|人类血小板反应蛋白2(THBS2),mRNA|qPCR正向引物匹配[3558..3580]|qPCR反向引物匹配[3682..3655]|qPCR探针匹配[3597..3623]
GAGGAGGAGACGGCATCCAGTACAGAGGGGCTGGACTTGGACCCCTGCAGCAGCCCTGCACAGGAGAAGCGGCATATAAAGCCGCGCTGCCCGGGAGCCGCTCGGCCACGTCCACCGGAGCATCCTGCACTGCAGGGCCGGTCTCTCGCTCCAGCAGAGCCTGCGCCTTTCTGACTCGGTCCGGAACACTGAAACCAGTCATCACTGCATCTTTTTGGCAAACCAGGAGCTCAGCTGCAGGAGGCAGGATGGTCTGGAGGCTGGTCCTGCTGGCTCTGTGGGTGTGGCCCAGCACGCAAGCTGGTCACCAGGACAAAGACACGACCTTCGACCTTTTCAGTATCAGCAACATCAACCGCAAGACCATTGGCGCCAAGCAGTTCCGCGGGCCCGACCCCGGCGTGCCGGCTTACCGCTTCGTGCGCTTTGACTACATCCCACCGGTGAACGCAGATGACCTCAGCAAGATCACCAAGATCATGCGGCAGAAGGAGGGCTTCTTCCTCACGGCCCAGCTCAAGCAGGACGGCAAGTCCAGGGGCACGCTGTTGGCTCTGGAGGGCCCCGGTCTCTCCCAGAGGCAGTTCGAGATCGTCTCCAACGGCCCCGCGGACACGCTGGATCTCACCTACTGGATTGACGGCACCCGGCATGTGGTCTCCCTGGAGGACGTCGGCCTGGCTGACTCGCAGTGGAAGAACGTCACCGTGCAGGTGGCTGGCGAGACCTACAGCTTGCACGTGGGCTGCGACCTCATAGACAGCTTCGCTCTGGACGAGCCCTTCTACGAGCACCTGCAGGCGGAAAAGAGCCGGATGTACGTGGCCAAAGGCTCTGCCAGAGAGAGTCACTTCAGGGGTTTGCTTCAGAACGTCCACCTAGTGTTTGAAAACTCTGTGGAAGATATTCTAAGCAAGAAGGGTTGCCAGCAAGGCCAGGGAGCTGAGATCAACGCCATCAGTGAGAACACAGAGACGCTGCGCCTGGGTCCGCATGTCACCACCGAGTACGTGGGCCCCAGCTCGGAGAGGAGGCCCGAGGTGTGCGAACGCTCGTGCGAGGAGCTGGGAAACATGGTCCAGGAGCTCTCGGGGCTCCACGTCCTCGTGAACCAGCTCAGCGAGAACCTCAAGAGAGTGTCGAATGATAACCAGTTTCTCTGGGAGCTCATTGGTGGCCCTCCTAAGACAAGGAACATGTCAGCTTGCTGGCAGGATGGCCGGTTCTTTGCGGAAAATGAAACGTGGGTGGTGGACAGCTGCACCACGTGTACCTGCAAGAAATTTAAAACCATTTGCCACCAAATCACCTGCCCGCCTGCAACCTGCGCCAGTCCATCCTTTGTGGAAGGCGAATGCTGCCCTTCCTGCCTCCACTCGGTGGACGGTGAGGAGGGCTGGTCTCCGTGGGCAGAGTGGACCCAGTGCTCCGTGACGTGTGGCTCTGGGACCCAGCAGAGAGGCCGGTCCTGTGACGTCACCAGCAACACCTGCTTGGGGCCCTCCATCCAGACACGGGCTTGCAGTCTGAGCAAGTGTGACACCCGCATCCGGCAGGACGGCGGCTGGAGCCACTGGTCACCTTGGTCTTCATGCTCTGTGACCTGTGGAGTTGGCAATATCACACGCATCCGTCTCTGCAACTCCCCAGTGCCCCAGATGGGGGGCAAGAATTGCAAAGGGAGTGGCCGGGAGACCAAAGCCTGCCAGGGCGCCCCATGCCCAATCGATGGCCGCTGGAGCCCCTGGTCCCCGTGGTCGGCCTGCACTGTCACCTGTGCCGGTGGGATCCGGGAGCGCACCCGGGTCTGCAACAGCCCTGAGCCTCAGTACGGAGGGAAGGCCTGCGTGGGGGATGTGCAGGAGCGTCAGATGTGCAACAAGAGGAGCTGCCCCGTGGATGGCTGTTTATCCAACCCCTGCTTCCCGGGAGCCCAGTGCAGCAGCTTCCCCGATGGGTCCTGGTCATGCGGCTCCTGCCCTGTGGGCTTCTTGGGCAATGGCACCCACTGTGAGGACCTGGACGAGTGTGCCCTGGTCCCCGACATCTGCTTCTCCACCAGCAAGGTGCCTCGCTGTGTCAACACTCAGCCTGGCTTCCACTGCCTGCCCTGCCCGCCCCGATACAGAGGGAACCAGCCCGTCGGGGTCGGCCTGGAAGCAGCCAAGACGGAAAAGCAAGTGTGTGAGCC CGAAAACCCATGCAAGGACAAGACACACAACTGCCACAAGCACGCGGAGTGCATCTACCTGGGCCACTTCAGCGACCCCATGTACAAGTGCGAGTGCCAGACAGGCTACGCGGGCGACGGGCTCATCTGCGGGGAGGACTCGGACCTGGACGGCTGGCCCAACCTCAATCTGGTCTGCGCCACCAACGCCACCTACCACTGCATCAAGGATAACTGCCCCCATCTGCCAAATTCTGGGCAGGAAGACTTTGACAAGGACGGGATTGGCGATGCCTGTGATGATGACGATGACAATGACGGTGTGACCGATGAGAAGGACAACTGCCAGCTCCTCTTCAATCCCCGCCAGGCTGACTATGACAAGGATGAGGTTGGGGACCGCTGTGACAACTGCCCTTACGTGCACAACCCTGCCCAGATCGACACAGACAACAATGGAGAGGGTGACGCCTGCTCCGTGGACATTGATGGGGACGATGTCTTCAATGAACGAGACAATTGTCCCTACGTCTACAACACTGACCAGAGGGACACGGATGGTGACGGTGTGGGGGATCACTGTGACAACTGCCCCCTGGTGCACAACCCTGACCAGACCGACGTGGACAATGACCTTGTTGGGGACCAGTGTGACAACAACGAGGACATAGATGACGACGGCCACCAGAACAACCAGGACAACTGCCCCTACATCTCCAACGCCAACCAGGCTGACCATGACAGAGACGGCCAGGGCGACGCCTGTGACCCTGATGATGACAACGATGGCGTCCCCGATGACAGGGACAACTGCCGGCTTGTGTTCAACCCAGACCAGGAGGACTTGGACGGTGATGGACGGGGTGATATTTGTAAAGATGATTTTGACAATGACAACATCCCAGATATTGATGATGTGTGTCCTGAAAACAATGCCATCAGTGAGACAGACTTCAGGAACTTCCAGATGGTCCCCTTGGATCCCAAAGGGACCACCCAAATTGATCCCAACTGGGTCATTCGCCATCAAGGCAAGGAGCTGGTTCAGACAGCCAACTCGGACCCCGGCATCGCTGTAGGTTTTGACGAGTTTGGGTCTGTGGACTTCAGTGGCACATTCTACGTAAACACTGACCGGGACGACGACTATGCCGGCTTCGTCTTTGGTTACCAGTCAAGCAGCCGCTTCTATGTGGTGATGTGGAAGCAGGTGACGCAGACCTACTGGGAGGACCAGCCCACGCGGGCCTATGGCTACTCCGGCGTGTCCCTCAAGGTGGTGAACTCCACCACGGGGACGGGCGAGCACCTGAGGAACGCGCTGTGGCACACGGGGAACACGCCGGGGCAGGTGCGAACCTTATGGCACGACCCCAGGAACATTGGCTGGAAGGACTACACGGCCTATAGGTGGCACCTGACTCACAGGCCCAAGACTGGCTACATCAGAGTCTTAGTGCATGAAGGAAAACAGGTCATGGCAGACTCAGGACCTATCTATGACCAAACCTACGCTGGCGGGCGGCTGGGTCTATTTGTCTTCTCTCAAGAAATGGTCTATTTCTCAGACCTCAAGTACGAATGCAGAGATATTTAAACAAGATTTGCTGCATTTCCGGCAATGCCCTGTGCATGCCATGGTCCCTAGACACCTCAGTTCATTGTGGTCCTTGTGGCTTCTCTCTCTAGCAGCACCTCCTGTCCCTTGACCTTAACTCTGATGGTTCTTCACCTCCTGCCAGCAACCCCAAACCCAAGTGCCTTCAGAGGATAAATATCAATGGAACTCAGAGATGAACATCTAACCCACTAGAGGAAACCAGTTTGGTGATATATGAGACTTTATGTGGAGTGAAAATTGGGCATGCCATTACATTGCTTTTTCTTGTTTGTTTAAAAAGAATGACGTTTACATATAAAATGTAATTACTTATTGTATTTATGTGTATATGGAGTTGAAGGGAATACTGTGCATAAGCCATTATGATAAATTAAGCATGAAAAATATTGCTGAACTACTTTTGGTGCTTAAAGTTGTCACTATTCTTGAATTAGAGTTGCTCTACAATGACACACAAATCCCATTAAATAAATTATAAACAAGGGTCAATTCAAATTTGAAGTAATGTTTTAGTAAGGAGAGATTAGAAGACAACAGGCATAGCAAATGACATAAGCTACCGATTAACTAATCGGAACATGTAAAACAGTTACAAAAATAAACGAACTCTCCTCTTGTCCTACAATGAAAGCCCTCATGTGCAGTAGAGATGCAGTTTCATCAAAGAACAAACATCCTTGCAAATGGGTGTGACGCGGTTCCAGATGTGGATTTGGCAAAACCTCATTTAAGTAAAAGGTTAGCAGAGCAAAGTGCGGTGCTTTAGCTGCTGCTTGTGCCGCTGTGGCGTCGGGGAGGCTCCTGCCTGAGCTTCCTTCCCCAGCTTTGCTGCCTGAGAGGAACCAGAGCAGACGCACAGGCCGGAAAAGGCGCATCTAACGCGTATCTAGGCTTTGGTAACTGCGGACAAGTTGCTTTTACCTGATTTGATGATACATTTCATTAAGGTTCCAGTTATAAATATTTTGTTAATATTTATTAAGTGACTATAGAATGCAACTCCATTTACCAGTAACTTATTTTAAATATGCCTAGTAACACATATGTAGTATAATTTCTAGAAACAAACATCTAATAAGTATATAATCCTGTGAAAATATGAGGCTTGATAATATTAGGTTGTCACGATGAAGCATGCTAGAAGCTGTAACAGAATACATAGAGAATAATGAGGAGTTTATGATGGAACCTTAAATATATAATGTTGCCAGCGATTTTAGTTCAATATTTGTTACTGTTATCTATCTGCTGTATATGGAATTCTTTTAATTCAAACGCTGAAAAGAATCAGCATTTAGTCTTGCCAGGCACACCCAATAATCAGTCATGTGTAATATGCACAAGTTTGTTTTTGTTTTTGTTTTTTTTGTTGGTTGGTTTGTTTTTTTGCTTTAAGTTGCATGATCTTTCTGCAGGAAATAGTCACTCATCCCACTCCACATAAGGGGTTTAGTAAGAGAAGTCTGTCTGTCTGATGATGGATAGGGGGCAAATCTTTTTCCCCTTTCTGTTAATAGTCATCACATTTCTATGCCAAACAGGAACAATCCATAACTTTAGTCTTAATGTACACATTGCATTTTGATAAAATTAATTTTGTTGTTTCCTTTGAGGTTGATCGTTGTGTTGTTGTTTTGCTGCACTTTTTACTTTTTTGCGTGTGGAGCTGTATTCCCGAGACCAACGAAGCGTTGGGATACTTCATTAAATGTAGCGACTGTCAACAGCGTGCAGGTTTTCTGTTTCTGTGTTGTGGGGTCAACCGTACAATGGTGTGGGAGTGACGATGATGTGAATATTTAGAATGTACCATATTTTTTGTAAATTATTTATGTTTTTCTAAACAAATTTATCGTATAGGTTGATGAAACGTCATGTGTTTTGCCAAAGACTGTAAATATTTATTTATGTGTTCACATGGTCAAAATTTCACCACTGAAACCCTGCACTTAGCTAGAACCTCATTTTTAAAGATTAACAACAGGAAATAAATTGTAAAAAAGGTTTTCTATACATGAAAAAAAAAAAAAAAAAA SEQ ID NO:94
Adlican
>gi|18390318|ref|NM_015419.1|人类adlican(DKFZp564I1922),mRNA|qPCR据assay_on_demand情况匹配[694..718]
ATGCCCAAGCGCGCGCACTGGGGGGCCCTCTCCGTGGTGCTGATCCTGCTTTGGGGCCATCCGCGAGTGGCGCTGGCCTGCCCGCATCCTTGTGCCTGCTACGTCCCCAGCGAGGTCCACTGCACGTTCCGATCCCTGGCTTCCGTGCCCGCTGGCATTGCTAGACACGTGGAAAGAATCAATTTGGGGTTTAATAGCATACAGGCCCTGTCAGAAACCTCATTTGCAGGACTGACCAAGTTGGAGCTACTTATGATTCACGGCAATGAGATCCCAAGCATCCCCGATGGAGCTTTAAGAGACCTCAGCTCTCTTCAGGTTTTCAAGTTCAGCTACAACAAGCTGAGAGTGATCACAGGACAGACCCTCCAGGGTCTCTCTAACTTAATGAGGCTGCACATTGACCACAACAAGATCGAGTTTATCCACCCTCAAGCTTTCAACGGCTTAACGTCTCTGAGGCTACTCCATTTGGAAGGAAATCTCCTCCACCAGCTGCACCCCAGCACCTTCTCCACGTTCACATTTTTGGATTATTTCAGACTCTCCACCATAAGGCACCTCTACTTAGCAGAGAACATGGTTAGAACTCTTCCTGCCAGCATGCTTCGGAACATGCCGCTTCTGGAGAATCTTTACTTGCAGGGAAATCCGTGGACCTGCGATTGTGAGATGAGATGGTTTTTGGAATGGGATGCAAAATCCAGAGGAATTCTGAAGTGTAAAAAGGACAAAGCTTATGAAGGCGGTCAGTTGTGTGCAATGTGCTTCAGTCCAAAGAAGTTGTACAAACATGAGATACACAAGCTGAAGGACATGACTTGTCTGAAGCCTTCAATAGAGTCCCCTCTGAGACAGAACAGGAGCAGGAGTATTGAGGAGGAGCAAGAACAGGAAGAGGATGGTGGCAGCCAGCTCATCCTGGAGAAATTCCAACTGCCCCAGTGGAGCATCTCTTTGAATATGACCGACGAGCACGGGAACATGGTGAACTTGGTCTGTGACATCAAGAAACCAATGGATGTGTACAAGATTCACTTGAACCAAACGGATCCTCCAGATATTGACATAAATGCAACAGTTGCCTTGGACTTTGAGTGTCCAATGACCCGAGAAAACTATGAAAAGCTATGGAAATTGATAGCATACTACAGTGAAGTTCCCGTGAAGCTACACAGAGAGCTCATGCTCAGCAAAGACCCCAGAGTCAGCTACCAGTACAGGCAGGATGCTGATGAGGAAGCTCTTTACTACACAGGTGTGAGAGCCCAGATTCTTGCAGAACCAGAATGGGTCATGCAGCCATCCATAGATATCCAGCTGAACCGACGTCAGAGTACGGCCAAGAAGGTGCTACTTTCCTACTACACCCAGTATTCTCAAACAATATCCACCAAAGATACAAGGCAGGCTCGGGGCAGAAGCTGGGTAATGATTGAGCCTAGTGGAGCTGTGCAAAGAGATCAGACTGTCCTGGAAGGGGGTCCATGCCAGTTGAGCTGCAACGTGAAAGCTTCTGAGAGTCCATCTATCTTCTGGGTGCTTCCAGATGGCTCCATCCTGAAAGCGCCCATGGATGACCCAGACAGCAAGTTCTCCATTCTCAGCAGTGGCTGGCTGAGGATCAAGTCCATGGAGCCATCTGACTCAGGCTTGTACCAGTGCATTGCTCAAGTGAGGGATGAAATGGACCGCATGGTATATAGGGTACTTGTGCAGTCTCCCTCCACTCAGCCAGCCGAGAAAGACACAGTGACAATTGGCAAGAACCCAGGGGAGTCGGTGACATTGCCTTGCAATGCTTTAGCAATACCCGAAGCCCACCTTAGCTGGATTCTTCCAAACAGAAGGATAATTAATGATTTGGCTAACACATCACATGTATACATGTTGCCAAATGGAACTCTTTCCATCCCAAAGGTCCAAGTCAGTGATAGTGGTTACTACAGATGTGTGGCTGTCAACCAGCAAGGGGCAGACCATTTTACGGTGGGAATCACAGTGACCAAGAAAGGGTCTGGCTTGCCATCCAAAAGAGGCAGACGCCCAGGTGCAAAGGCTCTTTCCAGAGTCAGAGAAGACATCGTGGAGGATGAAGGGGGCTCGGGCATGGGAGATGAAGAGAACACTTCAAGGAGACTTCTGCATCCAAAGGACCAAGAGGTGTTCCTCAAAACAAAGGATGATGCCATCAATGGAGACAAGAAAGCCAAGAAAGGGAGAAGAAAGCTGAAACTCTGGAAGCATTCGGAAAAAGAACCAGAGACCAATGTTGCAGAAGGTCGCAGAGTGTTTGAATCTAGACGAAGGATAAACATGGCAAACAAACAGATTAATCCGGAGCGCTGGGCTGATATTTTAGCCAAAGTCCGTGGGAAAAATCTCCCTAAGGGCACAGAAGTACCCCCGTTGATTAAAACCACAAGTCCTCCATCCTTGAGCCTAGAAGTCACACCACCTTTTCCTGCTGTTTCTCCCCCCTCAGCATCTCCTGTGCAGACAGTAACCAGTGCTGAAGAATCCTCAGCAGATGTACCTCTACTTGGTGAAGAAGAGCACGTTTTGGGTACCATTTCCTCAGCCAGCATGGGGCTAGAACACAACCACAATGGAGTTATTCTTGTTGAACCTGAAGTAACAAGCACACCTCTGGAGGAAGTTGTTGATGACCTTTCTGAGAAGACTGAGGAGATAACTTCCACTGAAGGAGACCTGAAGGGGACAGCAGCCCCTACACTTATATCTGAGCCTTATGAACCATCTCCTACTCTGCACACATTAGACACAGTCTATGAAAAGCCCACCCATGAAGAGACGGCAACAGAGGGTTGGTCTGCAGCAGATGTTGGATCGTCACCAGAGCCCACATCCAGTGAGTATGAGCCTCCATTGGATGCTGTCTCCTTGGCTGAGTCTGAGCCCATGCAATACTTTGACCCAGATTTGGAGACTAAGTCACAACCAGATGAGGATAAGATGAAAGAAGACACCTTTGCACACCTTACTCCAACCCCCACCATCTGGGTTAATGACTCCAGTACATCACAGTTATTTGAGGATTCTACTATAGGGGAACCAGGTGTCCCAGGCCAATCACATCTACAAGGACTGACAGACAACATCCACCTTGTGAAAAGTAGTCTAAGCACTCAAGACACCTTACTGATTAAAAAGGGTATGAAAGAGATGTCTCAGACACTACAGGGAGGAAATATGCTAGAGGGAGACCCCACACACTCCAGAAGTTCTGAGAGTGAGGGCCAAGAGAGCAAATCCATCACTTTGCCTGACTCCACACTGGGTATAATGAGCAGTATGTCTCCAGTTAAGAAGCCTGCGGAAACCACAGTTGGTACCCTCCTAGACAAAGACACCACAACAGTAACAACAACACCAAGGCAAAAAGTTGCTCCGTCATCCACCATGAGCACTCACCCTTCTCGAAGGAGACCCAACGGGAGAAGGAGATTACGCCCCAACAAATTCCGCCACCGGCACAAGCAAACCCCACCCACAACTTTTGCCCCATCAGAGACTTTTTCTACTCAACCAACTCAAGCACCTGACATTAAGATTTCAAGTCAAGTGGAGAGTTCTCTGGTTCCTACAGCTTGGGTGGATAACACAGTTAATACCCCCAAACAGTTGGAAATGGAGAAGAATGCAGAACCCACATCCAAGGGAACACCACGGAGAAAACACGGGAAGAGGCCAAACAAACATCGATATACCCCTTCTACAGTGAGCTCAAGAGCGTCCGGATCCAAGCCCAGCCCTTCTCCAGAAAATAAACATAGAAACATTGTTACTCCCAGTTCAGAAACTATACTTTTGCCTAGAACTGTTTCTCTGAAAACTGAGGGCCCTTATGATTCCTTAGATTACATGACAACCACCAGAAAAATATATTCATCTTACCCTAAAGTCCAAGAGACACTTCCAGTCACATATAAACCCACATCAGATGGAAAAGAAATTAAGGATGATGTTGCCACAAATGTTGACAAACATAAAAGTGACATTTTAGTCACTGGTGAATCAATTACTAATGCCATACCAACTTCTCGCTCCTTGGTCTCCACTATGGGAGAATTTAAGGAAGAATCCTCTCCTGTAGGCTTTCCAGGAACTCCAACCTGGAATCCCTCAAGGACGGCCCAGCCTGGGAGGCTACAGACAGACATACCTGTTACCACTTCTGGGGAAAATCTTACAGACCCTCCCCTTCTTAAAGAGCTTGAGGATGTGGATTTCACTTCCGAGTTTTTGTCCTCTTTGACAGTCTCCACACCATTTCACCAGGAAGAAGCTGGTTCTTCCACAACTCTCTCAAGCATAAAAGTGGAGGTGGCTTCAAGTCAGGCAGAAACCACCACCCTTGATCAAGATCATCTTGAAACCACTGTGGCTATTCTCCTTTCTGAAACTAGACCACAGAATCACACCCCTACTGCTGCCCGGATGAAGGAGCCAGCATCCTCGTCCCCATCCACAATTCTCATGTCTTTGGGACAAACCACCACCACTAAGCCAGCACTTCCCAGTCCAAGAATATCTCAAGCATCTAGAGATTCCAAGGAAAATGTTTTCTTGAATTATGTGGGGAATCCAGAAACAGAAGCAACCCCAGTCAACAATGAAGGAACACAGCATATGTCAGGGCCAAATGAATTATCAACACCCTCTTCCGACCGGGATGCATTTAACTTGTCTACAAAGCTGGAATTGGAAAAGCAAGTATTTGGTAGTAGGAGTCTACCACGTGGCCCAGATAGCCAACGCCAGGATGGAAGAGTTCATGCTTCTCATCAACTAACCAGAGTCCCTGCCAAACCCATCCTACCAACAGCAACAGTGAGGCTACCTGAAATGTCCACACAAAGCGCTTCCAGATACTTTGTAACTTCCCAGTCACCTCGTCACTGGACCAACAAACCGGAAATAACTACATATCCTTCTGGGGCTTTGCCAGAGAACAAACAGTTTACAACTCCAAGATTATCAAGTACAACAATTCCTCTCCCATTGCACATGTCCAAACCCAGCATTCCTAGTAAGTTTACTGACCGAAGAACTGACCAATTCAATGGTTACTCCAAAGTGTTTGGAAATAACAACATCCCTGAGGCAAGAAACCCAGTTGGAAAGCCTCCCAGTCCAAGAATTCCTCATTATTCCAATGGAAGACTCCCTTTCTTTACCAACAAGACTCTTTCTTTTCCACAGTTGGGAGTCACCCGGAGACCCCAGATACCCACTTCTCCTGCCCCAGTAATGAGAGAGAGAAAAGTTATTCCAGGTTCCTACAACAGGATACATTCCCATAGCACCTTCCATCTGGACTTTGGCCCTCCGGCACCTCCGTTGTTGCACACTCCGCAGACCACGGGATCACCCTCAACTAACTTACAGAATATCCCTATGGTCTCTTCCACCCAGAGTTCTATCTCCTTTATAACATCTTCTGTCCAGTCCTCAGGAAGCTTCCACCAGAGCAGCTCAAAGTTCTTTGCAGGAGGACCTCCTGCATCCAAATTCTGGTCTCTTGGGGAAAAGCCCCAAATCCTCACCAAGTCCCCACAGACTGTGTCCGTCACCGCTGAGACAGACACTGTGTTCCCCTGTGAGGCAACAGGAAAACCAAAGCCTTTCGTTACTTGGACAAAGGTTTCCACAGGAGCTCTTATGACTCCGAATACCAGGATACAACGGTTTGAGGTTCTCAAGAACGGTACCTTAGTGATACGGAAGGTTCAAGTACAAGATCGAGGCCAGTATATGTGCACCGCCAGCAACCTGCACGGCCTGGACAGGATGGTGGTCTTGCTTTCGGTCACCGTGCAGCAACCTCAAATCCTAGCCTCCCACTACCAGGACGTCACTGTCTACCTGGGAGACACCATTGCAATGGAGTGTCTGGCCAAAGGGACCCCAGCCCCCCAAATTTCCTGGATCTTCCCTGACAGGAGGGTGTGGCAAACTGTGTCCCCCGTGGAGAGCCGCATCACCCTGCACGAAAACCGGACCCTTTCCATCAAGGAGGCGTCCTTCTCAGACAGAGGCGTCTATAAGTGCGTGGCCAGCAATGCAGCCGGGGCGGACAGCCTGGCCATCCGCCTGCACGTGGCGGCACTGCCCCCCGTTATCCACCAGGAGAAGCTGGAGAACATCTCGCTGCCCCCGGGGCTCAGCATTCACATTCACTGCACTGCCAAGGCTGCGCCCCTGCCCAGCGTGCGCTGGGTGCTCGGGGACGGTACCCAGATCCGCCCCTCGCAGTTCCTCCACGGGAACTTGTTTGTTTTCCCCAACGGGACGCTCTACATCCGCAACCTCGCGCCCAAGGACAGCGGGCGCTATGAGTGCGTGGCCGCCAACCTGGTAGGCTCCGCGCGCAGGACGGTGCAGCTGAACGTGCAGCGTGCAGCAGCCAACGCGCGCATCACGGGCACCTCCCCGCGGAGGACGGACGTCAGGTACGGAGGAACCCTCAAGCTGGACTGCAGCGCCTCGGGGGACCCCTGGCCGCGCATCCTCTGGAGGCTGCCGTCCAAGAGGATGATCGACGCGCTCTTCAGTTTTGATAGCAGAATCAAGGTGTTTGCCAATGGGACCCTGGTGGTGAAATCAGTGACGGACAAAGATGCCGGAGATTACCTGTGCGTAGCTCGAAATAAGGTTGGTGATGACTACGTGGTGCTCAAAGTGGATGTGGTGATGAAACCGGCCAAGATTGAACACAAGGAGGAGAACGACCACAAAGTCTTCTACGGGGGTGACCTGAAAGTGGACTGTGTGGCCACCGGGCTTCCCAATCCCGAGATCTCCTGGAGCCTCCCAGACGGGAGTCTGGTGAACTCCTTCATGCAGTCGGATGACAGCGGTGGACGCACCAAGCGCTATGTCGTCTTCAACAATGGGACACTCTACTTTAACGAAGTGGGGATGAGGGAGGAAGGAGACTACACCTGCTTTGCTGAAAATCAGGTCGGGAAGGACGAGATGAGAGTCAGAGTCAAGGTGGTGACAGCGCCCGCCACCATCCGGAACAAGACTTACTTGGCGGTTCAGGTGCCCTATGGAGACGTGGTCACTGTAGCCTGTGAGGCCAAAGGAGAACCCATGCCCAAGGTGACTTGGTTGTCCCCAACCAACAAGGTGATCCCCACCTCCTCTGAGAAGTATCAGATATACCAAGATGGCACTCTCCTTATTCAGAAAGCCCAGCGTTCTGACAGCGGCAACTACACCTGCCTGGTCAGGAACAGCGCGGGAGAGGATAGGAAGACGGTGTGGATTCACGTCAACGTCCAGCCACCCAAGATCAACGGTAACCCCAACCCCATCACCACCGTGCGGGAGATAGCAGCCGGGGGCAGTCGGAAACTGATTGACTGCAAAGCTGAAGGCATCCCCACCCCGAGGGTGTTATGGGCTTTTCCCGAGGGTGTGGTTCTGCCAGCTCCATACTATGGAAACCGGATCACTGTCCATGGCAACGGTTCCCTGGACATCAGGAGTTTGAGGAAGAGCGACTCCGTCCAGCTGGTATGCATGGCACGCAACGAGGGAGGGGAGGCGAGGTTGATCGTGCAGCTCACTGTCCTGGAGCCCATGGAGAAACCCATCTTCCACGACCCGATCAGCGAGAAGATCACGGCCATGGCGGGCCACACCATCAGCCTCAACTGCTCTGCCGCGGGGACCCCGACACCCAGCCTGGTGTGGGTCCTTCCCAATGGCACCGATCTGCAGAGTGGACAGCAGCTGCAGCGCTTCTACCACAAGGCTGACGGCATGCTACACATTAGCGGTCTCTCCTCGGTGGACGCTGGGGCCTACCGCTGCGTGGCCCGCAATGCCGCTGGCCACACGGAGAGGCTGGTCTCCCTGAAGGTGGGACTGAAGCCAGAAGCAAACAAGCAGTATCATAACCTGGTCAGCATCATCAATGGTGAGACCCTGAAGCTCCCCTGCACCCCTCCCGGGGCTGGGCAGGGACGTTTCTCCTGGACGCTCCCCAATGGCATGCATCTGGAGGGCCCCCAAACCCTGGGACGCGTTTCTCTTCTGGACAATGGCACCCTCACGGTTCGTGAGGCCTCGGTGTTTGACAGGGGTACCTATGTATGCAGGATGGAGACGGAGTACGGCCCTTCGGTCACCAGCATCCCCGTGATTGTGATCGCCTATCCTCCCCGGATCACCAGCGAGCCCACCCCGGTCATCTACACCCGGCCCGGGAACACCGTGAAACTGAACTGCATGGCTATGGGGATTCCCAAAGCTGACATCACGTGGGAGTTACCGGATAAGTCGCATCTGAAGGCAGGGGTTCAGGCTCGTCTGTATGGAAACAGATTTCTTCACCCCCAGGGATCACTGACCATCCAGCATGCCACACAGAGAGATGCCGGCTTCTACAAGTGCATGGCAAAAAACATTCTCGGCAGTGACTCCAAAACAACTTACATCCACGTCTTCTGAAATGTGGATTCCAGAATGATTGCTTAGGAACTGACAACAAAGCGGGGTTTGTAAGGGAAGCCAGGTTGGGGAATAGGAGCTCTTAAATAATGTGTCACAGTGCATGGTGGCCTCTGGTGGGTTTCAAGTTGAGGTTGATCTTGATCTACAATTGTTGGGAAAAGGAAGCAATGCAGACACGAGAAGGAGGGCTCAGCCTTGCTGAGACACTTTCTTTTGTGTTTACATCATGCCAGGGGCTTCATTCAGGGTGTCTGTGCTCTGACTGCAATTTTTCTTCTTTTGCAAATGCCACTCGACTGCCTTCATAAGCGTCCATAGGATATCTGAGGAACATTCATCAAAAATAAGCCATAGACATGAACAACACCTCACTACCCCATTGAAGACGCATCACCTAGTTAACCTGCTGCAGTTTTTACATGATAGACTTTGTTCCAGATTGACAAGTCATCTTTCAGTTATTTCCTCTGTCACTTCAAAACTCCAGCTTGCCCAATAAGGATTTAGAACCAGAGTGACTGATATATATATATATATTTTAATTCAGAGTTACATACATACAGCTACCATTTTATATGAAAAAAGAAAAACATTTCTTCCTGGAACTCACTTTTTATATAATGTTTTATATATATATTTTTTCCTTTCAAATCAGACGATGAGACTAGAAGGAGAAATACTTTCTGTCTTATTAAAATTAATAAATTATTGGTCTTTACAAGACTTGGATACATTACAGCAGACATGGAAATATAATTTTAAAAAATTTCTCTCCAACCTCCTTCAAATTCAGTCACCACTGTTATATTACCTTCTCCAGGAACCCTCCAGTGGGGAAGGCTGCGATATTAGATTTCCTTGTATGCAAAGTTTTTGTTGAAAGCTGTGCTCAGAGGAGGTGAGAGGAGAGGAAGGAGAAAACTGCATCATAACTTTACAGAATTGAATCTAGAGTCTTCCCCGAAAAGCCCAGAAACTTCTCTGCAGTATCTGGCTTGTCCATCTGGTCTAAGGTGGCTGCTTCTTCCCCAGCCATGAGTCAGTTTGTGCCCATGAATAATACACGACCTGTTATTTCCATGACTGCTTTACTGTATTTTTAAGGTCAATATACTGTACATTTGATAATAAAATAATATTCTCCCAAAAAAAAAA SEQ ID NO:95
半胱氨酸蛋白酶抑制剂SA
>gi|19882252|ref|NM_001322.2|人类半胱氨酸蛋白酶抑制剂SA(CST2),mRNA|qPCR正向引物匹配[302..320]|qPCR反向引物匹配[393..370]|qPCR探针匹配[341..369]
GCCTCCGAGGAGACCATGGCCTGGCCCCTGTGCACCCTGCTGCTCCTGCTGGCCACCCAGGCTGTGGCCCTGGCCTGGAGCCCCCAGGAGGAGGACAGGATAATCGAGGGTGGCATCTATGATGCAGACCTCAATGATGAGCGGGTACAGCGTGCCCTTCACTTTGTCATCAGCGAGTATAACAAGGCCACTGAAGATGAGTACTACAGACGCCTGCTGCGGGTGCTACGAGCCAGGGAGCAGATCGTGGGCGGGGTGAATTACTTCTTCGACATAGAGGTGGGCCGAACCATATGTACCAAGTCCCAGCCCAACTTGGACACCTGTGCCTTCCATGAACAGCCAGAACTGCAGAAGAAACAGTTGTGCTCTTTCCAGATCTACGAAGTTCCCTGGGAGGACAGAATGTCCCTGGTGAATTCCAGGTGTCAAGAAGCCTAGGGATCTGTGCCAGGGAGTCACACTGACCACCTCCTACTCCCACCCCTTGTAGTGCTCCCACCCCTGGACTGGTGGCCCCCACCCTGTGGGAGGTCTCCCCATGCACCTGCAGCAGGAGAAGACAGAGAAGGCTGCAGGAGGCCTTTGTTGCTCAGCAGGGGACTCTGCCCTCCCTCCTTCCTTTTGCTTCTCATAGCCCTGGTACATGGTACACACACCCCCACCTCCTGCAATTAAACAGTAGCATCACCTC
SEQ ID NO:96
半胱氨酸蛋白酶抑制剂SN
>gi|19882250|ref|NM_001898.2|人类半胱氨酸蛋白酶抑制剂SN(CST1),mRNA|qPCR正向引物匹配[358..376]|qPCR反向引物匹配[449..426]|qPCR探针匹配[397..425]
GGGCTCCCTGCCTCGGGCTCTCACCCTCCTCTCCTGCAGCTCCAGCTTTGTGCTCTGCCTCTGAGGAGACCATGGCCCAGTATCTGAGTACCCTGCTGCTCCTGCTGGCCACCCTAGCTGTGGCCCTGGCCTGGAGCCCCAAGGAGGAGGATAGGATAATCCCGGGTGGCATCTATAACGCAGACCTCAATGATGAGTGGGTACAGCGTGCCCTTCACTTCGCCATCAGCGAGTATAACAAGGCCACCAAAGATGACTACTACAGACGTCCGCTGCGGGTACTAAGAGCCAGGCAACAGACCGTTGGGGGGGTGAATTACTTCTTCGACGTAGAGGTGGGCCGCACCATATGTACCAAGTCCCAGCCCAACTTGGACACCTGTGCCTTCCATGAACAGCCAGAACTGCAGAAGAAACAGTTGTGCTCTTTCGAGATCTACGAAGTTCCCTGGGAGAACAGAAGGTCCCTGGTGAAATCCAGGTGTCAAGAATCCTAGGGATCTGTGCCAGGCCATTCGCACCAGCCACCACCCACTCCCACCCCCTGTAGTGCTCCCACCCCTGGACTGGTGGCCCCCACCCTGCGGGAGGCCTCCCCATGTGCCTGCGCCAAGAGACAGACAGAGAAGGCTGCAGGAGTCCTTTGTTGCTCAGCAGGGCGCTCTGCCCTCCCTCCTTCCTTCTTGCTTCTAATAGCCCTGGTACATGGTACACACCCCCCCACCTCCTGCAATTAAACAGTAGCATCGCCTCCCTCTGAAAAAAAAAAAAAAAAAAAAAAA
SEQ ID NO:97
赖氨酰氧化酶样酶2
>gi|4505010|ref|NM_002318.1|人类赖氨酰氧化酶样酶2(LOXL2),mRNA|qPCR正向引物匹配[2205..2223]|qPCR反向引物匹配[2286..2269]|qPCR探针匹配[2261..2229]
ACTCCAGCGCGCGGCTACCTACGCTTGGTGCTTGCTTTCTCCAGCCATCGGAGACCAGAGCCGCCCCCTCTGCTCGAGAAAGGGGCTCAGCGGCGGCGGAAGCGGAGGGGGACCACCGTGGAGAGCGCGGTCCCAGCCCGGCCACTGCGGATCCCTGAAACCAAAAAGCTCCTGCTGCTTCTGTACCCCGCCTGTCCCTCCCAGCTGCGCAGGGCCCCTTCGTGGGATCATCAGCCCGAAGACAGGGATGGAGAGGCCTCTGTGCTCCCACCTCTGCAGCTGCCTGGCTATGCTGGCCCTCCTGTCCCCCCTGAGCCTGGCACAGTATGACAGCTGGCCCCATTACCCCGAGTACTTCCAGCAACCGGCTCCTGAGTATCACCAGCCCCAGGCCCCCGCCAACGTGGCCAAGATTCAGCTGCGCCTGGCTGGGCAGAAGAGGAAGCACAGCGAGGGCCGGGTGGAGGTGTACTATGATGGCCAGTGGGGCACCGTGTGCGATGACGACTTCTCCATCCACGCTGCCCACGTCGTCTGCCGGGAGCTGGGCTATGTGGAGGCCAAGTCCTGGACTGCCAGCTCCTCCTACGGCAAGGGAGAAGGGCCCATCTGGTTAGACAATCTCCACTGTACTGGCAACGAGGCGACCCTTGCAGCATGCACCTCCAATGGCTGGGGCGTCACTGACTGCAAGCACACGGAGGATGTCGGTGTGGTGTGCAGCGACAAAAGGATTCCTGGGTTCAAATTTGACAATTCGTTGATCAACCAGATAGAGAACCTGAATATCCAGGTGGAGGACATTCGGATTCGAGCCATCCTCTCAACCTACCGCAAGCGCACCCCAGTGATGGAGGGCTACGTGGAGGTGAAGGAGGGCAAGACCTGGAAGCAGATCTGTGACAAGCACTGGACGGCCAAGAATTCCCGCGTGGTCTGCGGCATGTTTGGCTTCCCTGGGGAGAGGACATACAATACCAAAGTGTACAAAATGTTTGCCTCACGGAGGAAGCAGCGCTACTGGCCATTCTCCATGGACTGCACCGGCACAGAGGCCCACATCTCCAGCTGCAAGCTGGGCCCCCAGGTGTCACTGGACCCCATGAAGAATGTCACCTGCGAGAATGGGCTGCCGGCCGTGGTGAGTTGTGTGCCTGGGCAGGTCTTCAGCCCTGACGGACCCTCGAGATTCCG GAAAGCATACAAGCCAGAGCAACCCCTGGTGCGACTGAGAGGCGGTGCCTACATCGGGGAGGGCCGCGTGGAGGTGCTCAAAAATGGAGAATGGGGGACCGTCTGCGACGACAAGTGGGACCTGGTGTCGGCCAGTGTGGTCTGCAGAGAGCTGGGCTTTGGGAGTGCCAAAGAGGCAGTCACTGGCTCCCGACTGGGGCAAGGGATCGGACCCATCCACCTCAACGAGATCCAGTGCACAGGCAATGAGAAGTCCATTATAGACTGCAAGTTCAATGCCGAGTCTCAGGGCTGCAACCACGAGGAGGATGCTGGTGTGAGATGCAACACCCCTGCCATGGGCTTGCAGAAGAAGCTGCGCCTGAACGGCGGCCGCAATCCCTACGAGGGCCGAGTGGAGGTGCTGGTGGAGAGAAACGGGTCCCTTGTGTGGGGGATGGTGTGTGGCCAAAACTGGGGCATCGTGGAGGCCATGGTGGTCTGCCGCCAGCTGGGCCTGGGATTCGCCAGCAACGCCTTCCAGGAGACCTGGTATTGGCACGGAGATGTCAACAGCAACAAAGTGGTCATGAGTGGAGTGAAGTGCTCGGGAACGGAGCTGTCCCTGGCGCACTGCCGCCACGACGGGGAGGACGTGGCCTGCCCCCAGGGCGGAGTGCAGTACGGGGCCGGAGTTGCCTGCTCAGAAACCGCCCCTGACCTGGTCCTCAATGCGGAGATGGTGCAGCAGACCACCTACCTGGAGGACCGGCCCATGTTCATGCTGCAGTGTGCCATGGAGGAGAACTGCCTCTCGGCCTCAGCCGCGCAGACCGACCCCACCACGGGCTACCGCCGGCTCCTGCGCTTCTCCTCCCAGATCCACAACAATGGCCAGTCCGACTTCCGGCCCAAGAACGGCCGCCACGCGTGGATCTGGCACGACTGTCACAGGCACTACCACAGCATGGAGGTGTTCACCCACTATGACCTGCTGAACCTCAATGGCACCAAGGTGGCAGAGGGCCACAAGGCCAGCTTCTGCTTGGAGGACACAGAATGTGAAGGAGACATCCAGAAGAATTACGAGTGTGCCAACTTCGGCGATCAGGGCATCACCATGGGCTGCTGGGACATGTACCGCCATGACATCGACTGCCAGTGGGTTGACATCACTGACGTGCCCCCTGGAGACTACCTGTTCCAGGTTGTTATTAACCCCAACTTCGAGGTTGCAGAATCCGATTACTCCAACAACATCATGAAATGCAGGAGCCGCTATGACGGCCACCGCATCTGGATGTACAACTGCCACATAGGTGGTTCCTTCAGCGAAGAGACGGAAAAAAAGTTTGAGCACTTCAGCGGGCTCTTAAACAACCAGCTGTCCCCGCAGTAAAGAAGCCTGCGTGGTCAACTCCTGTCTTCAGGCCACACCACATCTTCCATGGGACTTCCCCCCAACAACTGAGTCTGAACGAATGCCACGTGCCCTCACCCAGCCCGGCCCCCACCCTGTCCAGACCCCTACAGCTGTGTCTAAGCTCAGGAGGAAAGGGACCCTCCCATCATTCATGGGGGGCTGCTACCTGACCCTTGGGGCCTGAGAAGGCCTTGGGGGGGTGGGGTTTGTCCACAGAGCTGCTGGAGCAGCACCAAGAGCCAGTCTTGACCGGGATGAGGCCCACAGACAGGTTGTCATCAGCTTGTCCCATTCAAGCCACCGAGCTCACCACAGACACAGTGGAGCCGCGCTCTTCTCCAGTGACACGTGGACAAATGCGGGCTCATCAGCCCCCCCAGAGAGGGTCAGGCCGAACCCCATTTCTCCTCCTCTTAGGTCATTTTCAGCAAACTTGAATATCTAGACCTCTCTTCCAATGAAACCCTCCAGTCTATTATAGTCACATAGATAATGGTGCCACGTGTTTTCTGATTTGGTGAGCTCAGACTTGGTGCTTCCCTCTCCACAACCCCCACCCCTTGTTTTTCAAGATACTATTATTATATTTTCACAGACTTTTGAAGCACAAATTTATTGGCATTTAATATTGGACATCTGGGCCCTTGGAAGTACAAATCTAAGGAAAAACCAACCCACTGTGTAAGTGACTCATCTTCCTGTTGTTCCAATTCTGTGGGTTTTTGATTCAACGGTGCTATAACCAGGGTCCTGGGTGACAGGGCGCTCACTGAGCACCATGTGTCATCACAGACACTTACACATACTTGAAACTTGGAATAAAAGAAAGATTTATG SEQ ID NO:98
甲状腺球蛋白
>gi|33589851|ref|NM_003235.3|人类甲状腺球蛋白(TG),mRNA|qPCR正向引物匹配[886..905]|qPCR反向引物匹配[962..941]|qPCR探针匹配[915..939]
GCAGTGGTTTCTCCTCCTTCCTCCCAGGAAGGGCCAGGAAAATGGCCCTGGTCCTGGAGATCTTCACCCTGCTGGCCTCCATCTGCTGGGTGTCGGCCAATATCTTCGAGTACCAGGTTGATGCCCAGCCCCTTCGTCCCTGTGAGCTGCAGAGGGAAACGGCCTTTCTGAAGCAAGCAGACTACGTGCCCCAGTGTGCAGAGGATGGCAGCTTCCAGACTGTCCAGTGCCAGAACGACGGCCGCTCCTGCTGGTGTGTGGGTGCCAACGGCAGTGAAGTGCTGGGCAGCAGGCAGCCAGGACGGCCTGTGGCTTGTCTGTCATTTTGTCAGCTACAGAAACAGCAGATCTTACTGAGTGGCTACATTAACAGCACAGACACCTCCTACCTCCCTCAGTGTCAGGATTCAGGGGACTACGCGCCTGTTCAGTGTGATGTGCAGCATGTCCAGTGCTGGTGTGTGGACGCAGAGGGGATGGAGGTGTATGGGACCCGCCAGCTGGGGAGGCCAAAGCGATGTCCAAGGAGCTGTGAAATAAGAAATCGTCGTCTTCTCCACGGGGTGGGAGATAAGTCACCACCCCAGTGTTCTGCGGAGGGAGAGTTTATGCCTGTCCAGTGCAAATTTGTCAACACCACAGACATGATGATTTTTGATCTGGTCCACAGCTACAACAGGTTTCCAGATGCATTTGTGACCTTCAGTTCCTTCCAGAGGAGGTTCCCTGAGGTATCTGGGTATTGCCACTGTGCTGACAGCCAAGGGCGGGAACTGGCTGAGACAGGTTTGGAGTTGTTACTGGATGAAATTTATGACACCATTTTTGCTGGCCTGGACCTTCCTTCCACCTTCACTGAAACCACCCTGTACCGGATACTGCAGAGACGGTTCCTCGCAGTTCAATCAGTCATCTCTGGCAGATTCCGATGCCCCACAAAATGTGAAGTGGAGCGGTTTACAGCAACCAGCTTTGGTCACCCCTATGTTCCAAGCTGCCGCCGAAATGGCGACTATCAGGCGGTGCAGTGCCAGACGGAAGGGCCCTGCTGGTGTGTGGACGCCCAGGGGAAGGAAATGCATGGAACCCGGCAGCAAGGGGAGCCGCCATCTTGTGCTGAAGGCCAATCTTGTGCCTCCGAAAGGCAGCAGGCCTTGTCCAGACTCTACTTTGGGACCTCAGGCTACTTCAGCCAGCACGACCTGTTCTCTTCCCCAGAGAAAAGATGGGCCTCTCCAAGAGTAGCCAGATTTGCCACATCCTGCCCACCCACGATCAAGGAGCTCTTTGTGGACTCTGGGCTTCTCCGCCCAATGGTGGAGGGACAGAGCCAACAGTTTTCTGTCTCAGAAAATCTTCTCAAAGAAGCCATCCGAGCAATTTTTCCCTCCCGAGGGCTGGCTCGTCTTGCCCTTCAGTTTACCACCAACCCAAAGAGACTCCAGCAAAACCTTTTTGGAGGGAAATTTTTGGTGAATGTTGGCCAGTTTAACTTGTCTGGAGCCCTTGGCACAAGAGGCACATTTAACTTCAGTCAATTTTTCCAGCAACTTGGTCTTGCAAGCTTCTTGAATGGAGGGAGACAAGAAGATTTGGCCAAGCCACTCTCTGTGGGATTAGATTCAAATTCTTCCACAGGAACCCCTGAAGCTGCTAAGAAGGATGGTACTATGAATAAGCCAACTGTGGGCAGCTTTGGCTTTGAAATTAACCTACAAGAGAACCAAAATGCCCTCAAATTCCTTGCTTCTCTCCTGGAGCTTCCAGAATTCCTTCTCTTCTTGCAACATGCTATCTCTGTGCCAGAAGATGTGGCAAGAGATTTAGGTGATGTGATGGAAACGGTACTCGACTCCCAGACCTGTGAGCAGACACCTGAAAGGCTATTTGTCCCATCATGCACGACAGAAGGAAGCTATGAGGATGTCCAATGCTTTTCCGGAGAGTGCTGGTGTGTGAATTCCTGGGGCAAAGAGCTTCCAGGCTCAAGAGTCAGAGATGGACAGCCAAGGTGCCCCACAGACTGTGAAAAGCAAAGGGCTCGCATGCAAAGCCTCATGGGCAGCCAGCCTGCTGGCTCCACCTTGTTTGTCCCTGCTTGTACTAGTGAGGGACATTTCCTGCCTGTCCAGTGCTTCAACTCAGAGTGCTACTGTGTTGATGCTGAGGGTCAGGCCATTCCTGGAACTCGAAGTGCAATAGGGAAGCCCAAGAAATGCCCCACGCCCTGTCAATTACAGTCTGAGCAAGCTTTCCTCAGGACGGTGCAGGCCCTGCTCTCTAACTCCAGCATGCTACCCACCCTTTCCGACACCTACATCCCACAGTGCAGCACCGATGGGCAGTGGAGACAAGTGCAATGCAATGGGCCTCCTGAGCAGGTCTTCGAGTTGTACCAACGATGGGAGGCTCAGAACAAGGGCCAGGATCTGACGCCTGCCAAGCTGCTAGTGAAGATCATGAGCTACAGAGAAGCAGCTTCCGGAAACTTCAGTCTCTTTATTCAAAGTCTGTATGAGGCTGGCCAGCAAGATGTCTTCCCGGTGCTGTCACAATACCCTTCTCTGCAAGATGTCCCACTAGCAGCACTGGAAGGGAAACGGCCCCAGCCCAGGGAGAATATCCTCCTGGAGCCCTACCTCTTCTGGCAGATCTTAAATGGCCAACTCAGCCAATACCCGGGGTCCTACTCAGACTTCAGCACTCCTTTGGCACATTTTGATCTTCGGAACTGCTGGTGTGTGGATGAGGCTGGCCAAGAACTGGAAGGAATGCGGTCTGAGCCAAGCAAGCTCCCAACGTGTCCTGGCTCCTGTGAGGAAGCAAAGCTCCGTGTACTGCAGTTCATTAGGGAAACGGAAGAGATTGTTTCAGCTTCCAACAGTTCTCGGTTCCCTCTGGGGGAGAGTTTCCTGGTGGCCAAGGGAATCCGGCTGAGGAATGAGGACCTCGGCCTTCCTCCGCTCTTCCCGCCCCGGGAGGCTTTCGCGGAGTTTCTGCGTGGGAGTGATTACGCCATTCGCCTGGCGGCTCAGTCTACCTTAAGCTTCTATCAGAGACGCCGCTTTTCCCCGGACGACTCGGCTGGAGCATCCGCCCTTCTGCGGTCGGGCCCCTACATGCCACAGTGTGATGCGTTTGGAAGTTGGGAGCCTGTGCAGTGCCACGCTGGGACTGGGCACTGCTGGTGTGTAGATGAGAAAGGAGGGTTCATCCCTGGCTCACTGACTGCCCGCTCTCTGCAGATTCCACAGTGCCCGACAACCTGCGAGAAATCTCGAACCAGTGGGCTGCTTTCCAGTTGGAAACAGGCTAGATCCCAAGAAAACCCATCTCCAAAAGACCTGTTCGTCCCAGCCTGCCTAGAAACAGGAGAATATGCCAGGCTGCAGGCATCGGGGGCTGGCACCTGGTGTGTGGACCCTGCATCAGGAGAAGAGTTGCGGCCTGGCTCGAGCAGCAGTGCCCAGTGCCCAAGCCTCTGCAATGTGCTCAAGAGTGGAGTCCTCTCTAGGAGAGTCAGCCCAGGCTATGTCCCAGCCTGCAGGGCAGAGGATGGGGGCTTTTCCCCAGTGCAATGTGACCAGGCCCAGGGCAGCTGCTGGTGTGTCATGGACAGCGGAGAAGAGGTGCCTGGGACGCGCGTGACCGGGGGCCAGCCCGCCTGTGAGAGCCCGCGGTGTCCGCTGCCATTCAACGCGTCGGAGGTGGTTGGTGGAACAATCCTGTGTGAGACAATCTCGGGCCCCACAGGCTCTGCCATGCAGCAGTGCCAATTGCTGTGCCGCCAAGGCTCCTGGAGCGTGTTTCCACCAGGGCCATTGATATGTAGCCTGGAGAGCGGACGCTGGGAGTCACAGCTGCCTCAGCCCCGGGCCTGCCAACGGCCCCAGCTGTGGCAGACCATCCAGACCCAAGGGCACTTTCAGCTCCAGCTCCCGCCGGGCAAGATGTGCAGTGCTGACTACGCGGGTTTGCTGCAGACTTTCCAGGTTTTCATATTGGATGAGCTGACAGCCCGCGGCTTCTGCCAGATCCAGGTGAAGACTTTTGGCACCCTGGTTTCCATTCCTGTCTGCAACAACTCCTCTGTGCAGGTGGGTTGTCTGACCAGGGAGCGTTTAGGAGTGAATGTTACATGGAAATCACGGCTTGAGGACATCCCAGTGGCTTCTCTTCCTGACTTACATGACATTGAGAGAGCCTTGGTGGGCAAGGATCTCCTTGGGCGCTTCACAGATCTGATCCAGAGTGGCTCATTCCAGCTTCATCTGGACTCCAAGACGTTCCCAGCGGAAACCATCCGCTTCCTCCAAGGGGACCACTTTGGCACCTCTCCTAGGACACGGTTTGGGTGCTCGGAAGGATTCTACCAAGTCTTGACAAGTGAGGCCAGTCAGGACGGACTGGGATGCGTTAAGTGCCATGAAGGAAGCTATTCCCAAGATGAGGAATGCATTCCTTGTCCTGTTGGATTCTACCAAGAACAGGCAGGGAGCTTGGCCTGTGTCCCATGTCCTGTGGGCAGAACGACCATTTCTGCCGGAGCTTTCAGCCAGACTCACTGTGTCACTGACTGTCAGAGGAACGAAGCAGGCCTGCAATGTGACCAGAATGGCCAGTATCGAGCCAGCCAGAAGGACAGGGGCAGTGGGAAGGCCTTCTGTGTGGACGGCGAGGGGCGGAGGCTGCCATGGTGGGAAACAGAGGCCCCTCTTGAGGACTCACAGTGTTTGATGATGCAGAAGTTTGAGAAGGTTCCAGAATCAAAGGTGATCTTCGACGCCAATGCTCCTGTGGCTGTCAGATCCAAAGTTCCTGATTCTGAGTTCCCCGTGATGCAGTGCTTGACAGATTGCACAGAGGACGAGGCCTGCAGCTTCTTCACCGTGTCCACGACGGAGCCAGAGATTTCCTGTGATTTCTATGCTTGGACAAGTGACAATGTTGCCTGCATGACTTCTGACCAGAAACGAGATGCACTGGGGAACTCAAAGGCCACCAGCTTTGGAAGTCTTCGCTGCCAGGTGAAAGTGAGGAGCCATGGTCAAGATTCTCCAGCTGTGTATTTGAAAAAGGGCCAAGGATCCACCACAACACTTCAGAAACGCTTTGAACCCACTGGTTTCCAAAACATGCTTTCTGGATTGTACAACCCCATTGTGTTCTCAGCCTCAGGAGCCAATCTAACCGATGCTCACCTCTTCTGTCTTCTTGCATGCGACCGTGATCTGTGTTGCGATGGCTTCGTCCTCACACAGGTTCAAGGAGGTGCCATCATCTGTGGGTTGCTGAGCTCACCCAGTGTCCTGCTTTGTAATGTCAAAGACTGGATGGATCCCTCTGAAGCCTGGGCTAATGCTACATGTCCTGGTGTGACATATGACCAGGAGAGCCACCAGGTGATATTGCGTCTTGGAGACCAGGAGTTCATCAAGAGTCTGACACCCTTAGAAGGAACTCAAGACACCTTTACCAATTTTCAGCAGGTTTATCTCTGGAAAGATTCTGACATGGGGTCTCGGCCTGAGTCTATGGGATGTAGAAAAAACACAGTGCCAAGGCCAGCATCTCCAACAGAAGCAGGTTTGACAACAGAACTTTTCTCCCCTGTGGACCTCAACCAGGTCATTGTCAATGGAAATCAATCACTATCCAGCCAGAAGCACTGGCTTTTCAAGCACCTGTTTTCAGCCCAGCAGGCAAACCTATGGTGCCTTTCTCGTTGTGTGCAGGAGCACTCTTTCTGTCAGCTCGCAGAGATAACAGAGAGTGCATCCTTGTACTTCACCTGCACCCTCTACCCAGAGGCACAGGTGTGTGATGACATCATGGAGTCCAATACCCAGGGCTGCAGACTGATCCTGCCTCAGATGCCAAAGGCCCTGTTCCGGAAGAAAGTTATACTGGAAGATAAAGTGAAGAACTTTTACACTCGCCTGCCGTTCCAAAAACTGATGGGGATATCCATTAGAAATAAAGTGCCCATGTCTGAAAAATCTATTTCTAATGGGTTCTTTGAATGTGAACGACGGTGCGATGCGGACCCATGCTGCACTGGCTTTGGATTTCTAAATGTTTCCCAGTTAAAAGGAGGAGAGGTGACATGTCTCACTCTGAACAGCTTGGGAATTCAGATGTGCAGTGAGGAGAATGGAGGAGCCTGGCGCATTTTGGACTGTGGCTCTCCTGACATTGAAGTCCACACCTATCCCTTCGGATGGTACCAGAAGCCCATTGCTCAAAATAATGCTCCCAGTTTTTGCCCTTTGGTTGTTCTGCCTTCCCTCACAGAGAAAGTGTCTCTGGAATCGTGGCAGTCCCTGGCCCTCTCTTCAGTGGTTGTTGATCCATCCATTAGGCACTTTGATGTTGCCCATGTCAGCACTGCTGCCACCAGCAATTTCTCTGCTGTCCGAGACCTCTGTTTGTCGGAATGTTCCCAACATGAGGCCTGTCTCATCACCACTCTGCAAACCCAACTCGGGGCTGTGAGATGTATGTTCTATGCTGATACTCAAAGCTGCACACATAGTCTGCAGGGTCGGAACTGCCGACTTCTGCTTCGTGAAGAGGCCACCCACATCTACCGGAAGCCAGGAATCTCTCTGCTCAGCTATGAGGCATCTGTACCTTCTGTGCCCATTTCCACCCATGGCCGGCTGCTGGGCAGGTCCCAGGCCATCCAGGTGGGTACCTCATGGAAGCAAGTGGACCAGTTCCTTGGAGTTCCATATGCTGCCCCGCCCCTGGCAGAGAGGCACTTCCAGGCACCAGAGCCCTTGAACTGGACAGGCTCCTGGGATGCCAGCAAGCCAAGGGCCAGCTGCTGGCAGCCAGGCACCAGAACATCCACGTCTCCTGGAGTCAGTGAAGATTGTTTGTATCTCAATGTGTTCATCCCTCAGAATGTGGCCCCTAACGCGTCTGTGCTGGTGTTCTTCCACAACACCATGGACAGGGAGGAGAGTGAAGGATGGCCGGCTATCGACGGCTCCTTCTTGGCTGCTGTTGGCAACCTCATCGTGGTCACTGCCAGCTACCGAGTGGGTGTCTTCGGCTTCCTGAGTTCTGGATCCGGAGAGGTGAGTGGCAACTGGGGGCTGCTGGACCAGGTGGCGGCTCTGACCTGGGTGCAGACCCACATCCGAGGATTTGGCGGGGACCCTCGGCGCGTGTCCCTGGCAGCAGACCGTGGCGGGGCTGATGTGGCCAGCATCCACCTTCTCACGGCCAGGGCCACCAACTCCCAACTTTTCCGGAGAGCTGTGCTGATGGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGGAGGTCAGTTGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCAAGCTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGTCTTTATGGGTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGGAAAGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTGCTGCTACATGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACTTTATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCCATGGCAGCCTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGGAGAAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTACCCACATTTGCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGACAGGGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAGAGAGTGAAGAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCAAGTGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTTTTTCTCTAAAATAGTTACTTACCTTCAATAAAGTATCTACATGCGGTG SEQ ID NO:99
转化生长因子,β1
>gi|10863872|ref|NM_000660.1|人类转化生长因子,β1(卡-恩病)(TGFB1),mRNA|qPCR正向引物匹配[1651..1668]|qPCR反向引物匹配[1539..1557]|qPCR探针匹配[1687..1713]ACCTCCCTCCGCGGAGCAGCCAGACAGCGAGGGCCCCGGCCGGGGGCAGGGGGGACGCCCCGTCCGGGGCACCCCCCCCGGCTCTGAGCCGCCCGCGGGGCCGGCCTCGGCCCGGAGCGGAGGAAGGAGTCGCCGAGGAGCAGCCTGAGGCCCCAGAGTCTGAGACGAGCCGCCGCCGCCCCCGCCACTGCGGGGAGGAGGGGGAGGAGGAGCGGGAGGAGGGACGAGCTGGTCGGGAGAAGAGGAAAAAAACTTTTGAGACTTTTCCGTTGCCGCTGGGAGCCGGAGGCGCGGGGACCTCTTGGCGCGACGCTGCCCCGCGAGGAGGCAGGACTTGGGGACCCCAGACCGCCTCCCTTTGCCGCCGGGGACGCTTGCTCCCTCCCTGCCCCCTACACGGCGTCCCTCAGGCGCCCCCATTCCGGACCAGCCCTCGGGAGTCGCCGACCCGGCCTCCCGCAAAGACTTTTCCCCAGACCTCGGGCGCACCCCCTGCACGCCGCCTTCATCCCCGGCCTGTCTCCTGAGCCCCCGCGCATCCTAGACCCTTTCTCCTCCAGGAGACGGATCTCTCTCCGACCTGCCACAGATCCCCTATTCAAGACCACCCACCTTCTGGTACCAGATCGCGCCCATCTAGGTTATTTCCGTGGGATACTGAGACACCCCCGGTCCAAGCCTCCCCTCCACCACTGCGCCCTTCTCCCTGAGGAGCCTCAGCTTTCCCTCGAGGCCCTCCTACCTTTTGCCGGGAGACCCCCAGCCCCTGCAGGGGCGGGGCCTCCCCACCACACCAGCCCTGTTCGCGCTCTCGGCAGTGCCGGGGGGCGCCGCCTCCCCCATGCCGCCCTCCGGGCTGCGGCTGCTGCCGCTGCTGCTACCGCTGCTGTGGCTACTGGTGCTGACGCCTGGCCCGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTGGTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCCAGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTGTACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAGGCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACGAAATCTATGACAAGTTCAAGCAGAGTACACACAGCATATATATGTTCTTCAACACATCAGAGCTCCGAGAAGCGGTACCTGAACCCGTGTTGCTCTCCCGGGCAGAGCTGCGTCTGCTGAGGAGGCTCAAGTTAAAAGTGGAGCAGCACGTGGAGCTGTACCAGAAATACAGCAACAATTCCTGGCGATACCTCAGCAACCGGCTGCTGGCACCCAGCGACTCGCCAGAGTGGTTATCTTTTGATGTCACCGGAGTTGTGCGGCAGTGGTTGAGCCGTGGAGGGGAAATTGAGGGCTTTCGCCTTAGCGCCCACTGCTCCTGTGACAGCAGGGATAACACACTGCAAGTGGACATCAACGGGTTCACTACCGGCCGCCGAGGTGACCTGGCCACCATTCATGGCATGAACCGGCCTTTCCTGCTTCTCATGGCCACCCCGCTGGAGAGGGCCCAGCATCTGCAAAGCTCCCGGCACCGCCGAGCCCTGGACACCAACTATTGCTTCAGCTCCACGGAGAAGAACTGCTGCGTGCGGCAGCTGTACATTGACTTCCGCAAGGACCTCGGCTGGAAGTGGATCCACGAGCCCAAGGGCTACCATGCCAACTTCTGCCTCGGGCCCTGCCCCTACATTTGGAGCCTGGACACGCAGTACAGCAAGGTCCTGGCCCTGTACAACCAGCATAACCCGGGCGCCTCGGCGGCGCCGTGCTGCGTGCCGCAGGCGCTGGAGCCGCTGCCCATCGTGTACTACGTGGGCCGCAAGCCCAAGGTGGAGCAGCTGTCCAACATGATCGTGCGCTCCTGCAAGTGCAGCTGAGGTCCCGCCCCGCCCCGCCCCGCCCCGGCAGGCCCGGCCCCACCCCGCCCCGCCCCCGCTGCCTTGCCCATGGGGGCTGTATTTAAGGACACCGTGCCCCAAGCCCACCTGGGGCCCCATTAAAGATGGAGAGAGGACTGCGGATCTCTGTGTCATTGGGCGCCTGCCTGGGGTCTCCATCCCTGACGTTCCCCCACTCCCACTCCCTCTCTCTCCCTCTCTGCCTCCTCCTGCCTGTCTGCACTATTCCTTTGCCCGGCATCAAGGCACAGGGGACCAGTGGGGAACACTACTGTAGTTAGATCTATTTATTGAGCACCTTGGGCACTGTTGAAGTGCCTTACATTAATGAACTCATTCAGTCACCATAGCAACACTCTGAGATGGCAGGGACTCTGATAACACCCATTTTAAAGGTTGAGGAAACAAGCCCAGAGAGGTTAAGGGAGGAGTTCCTGCCCACCAGGAACCTGCTTTAGTGGGGGATAGTGAAGAAGACAATAAAAGATAGTAGTTCAGGCCAGGCGGGGTGCTCACGCCTGTAATCCTAGCACTTTTGGGAGGCAGAGATGGGAGGATACTTGAATCCAGGCATTTGAGACCAGCCTGGGTAACATAGTGAGACCCTATCTCTACAAAACACTTTTAAAAAATGTACACCTGTGGTCCCAGCTACTCTGGAGGCTAAGGTGGGAGGATCACTTGATCCTGGGAGGTCAAGGCTGCAG
SEQ ID NO:100
丝氨酸蛋白酶抑制剂,进化枝H,成员1
>gi|32454740|ref|NM_001235.2|人类丝氨酸(或半胱氨酸)蛋白酶抑制剂,进化枝H(热休克蛋白47)成员1(胶原结合蛋白1)(SERPINH1),mRNA|qPCR据assay_on_demand情况匹配[184..208]
TCTTTGGCTTTTTTTGGCGGAGCTGGGGCGCCCTCCGGAAGCGTTTCCAACTTTCCAGAAGTTTCTCGGGACGGGCAGGAGGGGGTGGGGACTGCCATATATAGATCCCGGGAGCAGGGGAGCGGGCTAAGAGTAGAATCGTGTCGCGGCTCGAGAGCGAGAGTCACGTCCCGGCGCTAGCCCAGCCCGACCCAGGCCCACCGTGGTGCACGCAAACCACTTCCTGGCCATGCGCTCCCTCCTGCTTCTCAGCGCCTTCTGCCTCCTGGAGGCGGCCCTGGCCGCCGAGGTGAAGAAACCTGCAGCCGCAGCAGCTCCTGGCACTGCGGAGAAGTTGAGCCCCAAGGCGGCCACGCTTGCCGAGCGCAGCGCCGGCCTGGCCTTCAGCTTGTACCAGGCCATGGCCAAGGACCAGGCAGTGGAGAACATCCTGGTGTCACCCGTGGTGGTGGCCTCGTCGCTAGGGCTCGTGTCGCTGGGCGGCAAGGCGACCACGGCGTCGCAGGCCAAGGCAGTGCTGAGCGCCGAGCAGCTGCGCGACGAGGAGGTGCACGCCGGCCTGGGCGAGCTGCTGCGCTCACTCAGCAACTCCACGGCGCGCAACGTGACCTGGAAGCTGGGCAGCCGACTGTACGGACCCAGCTCAGTGAGCTTCGCTGATGACTTCGTGCGCAGCAGCAAGCAGCACTACAACTGCGAGCACTCCAAGATCAACTTCCGCGACAAGCGCAGCGCGCTGCAGTCCATCAACGAGTGGGCCGCGCAGACCACCGACGGCAAGCTGCCCGAGGTCACCAAGGACGTGGAGCGCACGGACGGCGCCCTGCTAGTCAACGCCATGTTCTTCAAGCCACACTGGGATGAGAAATTCCACCACAAGATGGTGGACAACCGTGGCTTCATGGTGACTCGGTCCTATACCGTGGGTGTCATGATGATGCACCGGACAGGCCTCTACAACTACTACGACGACGAGAAGGAAAAGCTGCAAATCGTGGAGATGCCCCTGGCCCACAAGCTCTCCAGCCTCATCATCCTCATGCCCCATCACGTGGAGCCTCTCGAGCGCCTTGAAAAGCTGCTAACCAAAGAGCAGCTGAAGATCTGGATGGGGAAGATGCAGAAGAAGGCTGTTGCCATCTCCTTGCCCAAGGGTGTGGTGGAGGTGACCCATGACCTGCAGAAACACCTGGCTGGGCTGGGCCTGACTGAGGCCATTGACAAGAACAAGGCCGACTTGTCACGCATGTCAGGCAAGAAGGACCTGTACCTGGCCAGCGTGTTCCACGCCACCGCCTTTGAGTTGGACACAGATGGCAACCCCTTTGACCAGGACATCTACGGGCGCGAGGAGCTGCGCAGCCCCAAGCTGTTCTACGCCGACCACCCCTTCATCTTCCTAGTGCGGGACACCCAAAGCGGCTCCCTGCTATTCATTGGGCGCCTGGTCCGGCCTAAGGGTGACAAGATGCGAGACGAGTTATAGGGCCTCAGGGTGCACACAGGATGGCAGGAGGCATCCAAAGGCTCCTGAGACACATGGGTGCTATTGGGGTTGGGGGGGAGGTGAGGTACCAGCCTTGGATACTCCATGGGGTGGGGGTGGAAAAACAGACCGGGGTTCCCGTGTGCCTGAGCGGACCTTCCCAGCTAGAATTCACTCCACTTGGACATGGGCCCCAGATACCATGATGCTGAGCCCGGAAACTCCACATCCTGTGGGACCTGGGCCATAGTCATTCTGCCTGCCCTGAAAGTCCCAGATCAAGCCTGCCTCAATCAGTATTCATATTTATAGCCAGGTACCTTCTCACCTGTGAGACCAAATTGAGCTAGGGGGGTCAGCCAGCCCTCTTCTGACACTAAAACACCTCAGCTGCCTCCCCAGCTCTATCCCAACCTCTCCCAACTATAAAACTAGGTGCTGCAGCCCCTGGGACCAGGCACCCCCAGAATGACCTGGCCGCAGTGAGGCGGATTGAGAAGGAGCTCCCAGGAGGGGCTTCTGGGCAGACTCTGGTCAAGAAGCATCGTGTCTGGCGTTGTGGGGATGAACTTTTTGTTTTGTTTCTTCCTTTTTTAGTTCTTCAAAGATAGGGAGGGAAGGGGGAACATGAGCCTTTGTTGCTATCAATCCAAGAACTTATTTGTACATTTTTTTTTTCAATAAAACTTTTCCAATGACATTTTGTTGGAGCGTGGAAAAAA SEQ ID NO:101
丝氨酸蛋白酶抑制剂,进化枝B,成员5
>gi|4505788|ref|NM_002639.1|人类丝氨酸(或半胱氨酸)蛋白酶抑制剂,进化枝B(卵清蛋白),成员5(SERPINB5),mRNA|qPCR正向引物匹配[36..56]|qPCR反向引物匹配[106..86]|qPCR探针匹配[60..80]
GGCACGAGTTGTGCTCCTCGCTTGCCTGTTCCTTTTCCACGCATTTTCCAGGATAACTGTGACTCCAGGCCCGCAATGGATGCCCTGCAACTAGCAAATTCGGCTTTTGCCGTTGATCTGTTCAAACAACTATGTGAAAAGGAGCCACTGGGCAATGTCCTCTTCTCTCCAATCTGTCTCTCCACCTCTCTGTCACTTGCTCAAGTGGGTGCTAAAGGTGACACTGCAAATGAAATTGGACAGGTTCTTCATTTTGAAAATGTCAAAGATATACCCTTTGGATTTCAAACAGTAACATCGGATGTAAACAAACTTAGTTCCTTTTACTCACTGAAACTAATCAAGCGGCTCTACGTAGACAAATCTCTGAATCTTTCTACAGAGTTCATCAGCTCTACGAAGAGACCCTATGCAAAGGAATTGGAAACTGTTGACTTCAAAGATAAATTGGAAGAAACGAAAGGTCAGATCAACAACTCAATTAAGGATCTCACAGATGGCCACTTTGAGAACATTTTAGCTGACAACAGTGTGAACGACCAGACCAAAATCCTTGTGGTTAATGCTGCCTACTTTGTTGGCAAGTGGATGAAGAAATTTCCTGAATCAGAAACAAAAGAATGTCCTTTCAGACTCAACAAGACAGACACCAAACCAGTGCAGATGATGAACATGGAGGCCACGTTCTGTATGGGAAACATTGACAGTATCAATTGTAAGATCATAGAGCTTCCTTTTCAAAATAAGCATCTCAGCATGTTCATCCTACTACCCAAGGATGTGGAGGATGAGTCCACAGGCTTGGAGAAGATTGAAAAACAACTCAACTCAGAGTCACTGTCACAGTGGACTAATCCCAGCACCATGGCCAATGCCAAGGTCAAACTCTCCATTCCAAAATTTAAGGTGGAAAAGATGATTGATCCCAAGGCTTGTCTGGAAAATCTAGGGCTGAAACATATCTTCAGTGAAGACACATCTGATTTCTCTGGAATGTCAGAGACCAAGGGAGTGGCCCTATCAAATGTTATCCACAAAGTGTGCTTAGAAATAACTGAAGATGGTGGGGATTCCATAGAGGTGCCAGGAGCACGGATCCTGCAGCACAAGGATGAATTGAATGCTGACCATCCCTTTATTTACATCATCAGGCACAACAAAACTCGAAACATCATTTTCTTTGGCAAATTCTGTTCTCCTTAAGTGGCATAGCCCATGTTAAGTCCTCCCTGACTTTTCTGTGGATGCCGATTTCTGTAAACTCTGCATCCAGAGATTCATTTTCTAGATACAATAAATTGCTAATGTTGCTGGATCAGGAAGCCGCCAGTACTTGTCATATGTAGCCTTCACACAGATAGACCTTTTTTTTTTTCCAATTCTATCTTTTGTTTCCTTTTTTCCCATAAGACAATGACATACGCTTTTAATGAAAAGGAATCACGTTAGAGGAAAAATATTTATTCATTATTTGTCAAATTGTCCGGGGTAGTTGGCAGAAATACAGTCTTCCACAAAGAAAATTCCTATAAGGAAGATTTGGAAGCTCTTCTTCCCAGCACTATGCTTTCCTTCTTTGGGATAGAGAATGTTCCAGACATTCTCGCTTCCCTGAAAGACTGAAGAAAGTGTAGTGCATGGGACCCACGAAACTGCCCTGGCTCCAGTGAAACTTGGGCACATGCTCAGGCTACTATAGGTCCAGAAGTCCTTATGTTAAGCCCTGGCAGGCAGGTGTTTATTAAAATTCTGAATTTTGGGGATTTTCAAAAGATAATATTTTACATACACTGTATGTTATAGAACTTCATGGATCAGATCTGGGGCAGCAACCTATAAATCAACACCTTAATATGCTGCAACAAAATGTAGAATATTCAGACAAAATGGATACATAAAGACTAAGTAGCCCATAAGGGGTCAAAATTTGCTGCCAAATGCGTATGCCACCAACTTACAAAAACACTTCGTTCGCAGAGCTTTTCAGATTGTGGAATGTTGGATAAGGAATTATAGACCTCTAGTAGCTGAAATGCAAGACCCCAAGAGGAAGTTCAGATCTTAATATAAATTCACTTTCATTTTTGATAGCTGTCCCATCTGGTCATGTGGTTGGCACTAGACTGGTGGCAGGGGCTTCTAGCTGACTCGCACAGGGATTCTCACAATAGCCGATATCAGAATTTGTGTTGAAGGAACTTGTCTCTTCATCTAATATGATAGCGGGAAAAGGAGAGGAAACTACTGCCTTTAGAAAATATAAGTAAAGTGATTAAAGTGCTCACGTTACCTTGACACATAGTTTTTCAGTCTATGGGTTTAGTTACTTTAGATGGCAAGCATGTAACTTATATTAATAGTAATTTGTAAAGTTGGGTGGATAAGCTATCCCTGTTGCCGGTTCATGGATTACTTCTCTATAAAAAATATATATTTACCAAAAAATTTTGTGACATTCCTTCTCCCATCTCTTCCTTGACATGCATTGTAAATAGGTTCTTCTTGTTCTGAGATTCAATATTGAATTTCTCCTATGCTATTGACAATAAAATATTATTGAACTACC
SEQ ID NO:102
癌胚抗原相关细胞黏附分子5
>gi|11386170|ref|NM_004363.1|人类癌胚抗原相关细胞黏附分子5(CEACAM5),mRNA|qPCR据assay_on_demand情况匹配[2128..2152]
CTCAGGGCAGAGGGAGGAAGGACAGCAGACCAGACAGTCACAGCAGCCTTGACAAAACGTTCCTGGAACTCAAGCTCTTCTCCACAGAGGAGGACAGAGCAGACAGCAGAGACCATGGAGTCTCCCTCGGCCCCTCCCCACAGATGGTGCATCCCCTGGCAGAGGCTCCTGCTCACAGCCTCACTTCTAACCTTCTGGAACCCGCCCACCACTGCCAAGCTCACTATTGAATCCACGCCGTTCAATGTCGCAGAGGGGAAGGAGGTGCTTCTACTTGTCCACAATCTGCCCCAGCATCTTTTTGGCTACAGCTGGTACAAAGGTGAAAGAGTGGATGGCAACCGTCAAATTATAGGATATGTAATAGGAACTCAACAAGCTACCCCAGGGCCCGCATACAGTGGTCGAGAGATAATATACCCCAATGCATCCCTGCTGATCCAGAACATCATCCAGAATGACACAGGATTCTACACCCTACACGTCATAAAGTCAGATCTTGTGAATGAAGAAGCAACTGGCCAGTTCCGGGTATACCCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAAACCCGTGGAGGACAAGGATGCTGTGGCCTTCACCTGTGAACCTGAGACTCAGGACGCAACCTACCTGTGGTGGGTAAACAATCAGAGCCTCCCGGTCAGTCCCAGGCTGCAGCTGTCCAATGGCAACAGGACCCTCACTCTATTCAATGTCACAAGAAATGACACAGCAAGCTACAAATGTGAAACCCAGAACCCAGTGAGTGCCAGGCGCAGTGATTCAGTCATCCTGAATGTCCTCTATGGCCCGGATGCCCCCACCATTTCCCCTCTAAACACATCTTACAGATCAGGGGAAAATCTGAACCTCTCCTGCCACGCAGCCTCTAACCCACCTGCACAGTACTCTTGGTTTGTCAATGGGACTTTCCAGCAATCCACCCAAGAGCTCTTTATCCCCAACATCACTGTGAATAATAGTGGATCCTATACGTGCCAAGCCCATAACTCAGACACTGGCCTCAATAGGACCACAGTCACGACGATCACAGTCTATGCAGAGCCACCCAAACCCTTCATCACCAGCAACAACTCCAACCCCGTGGAGGATGAGGATGCTGTAGCCTTAACCTGTGAACCTGAGATTCAGAACACAACCTACCTGTGGTGGGTAAATAATCAGAGCCTCCCGGTCAGTCCCAGGCTGCAGCTGTCCAATGACAACAGGACCCTCACTCTACTCAGTGTCACAAGGAATGATGTAGGACCCTATGAGTGTGGAATCCAGAACGAATTAAGTGTTGACCACAGCGACCCAGTCATCCTGAATGTCCTCTATGGCCCAGACGACCCCACCATTTCCCCCTCATACACCTATTACCGTCCAGGGGTGAACCTCAGCCTCTCCTGCCATGCAGCCTCTAACCCACCTGCACAGTATTCTTGGCTGATTGATGGGAACATCCAGCAACACACACAAGAGCTCTTTATCTCCAACATCACTGAGAAGAACAGCGGACTCTATACCTGCCAGGCCAATAACTCAGCCAGTGGCCACAGCAGGACTACAGTCAAGACAATCACAGTCTCTGCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAAACCCGTGGAGGACAAGGATGCTGTGGCCTTCACCTGTGAACCTGAGGCTCAGAACACAACCTACCTGTGGTGGGTAAATGGTCAGAGCCTCCCAGTCAGTCCCAGGCTGCAGCTGTCCAATGGCAACAGGACCCTCACTCTATTCAATGTCACAAGAAATGACGCAAGAGCCTATGTATGTGGAATCCAGAACTCAGTGAGTGCAAACCGCAGTGACCCAGTCACCCTGGATGTCCTCTATGGGCCGGACACCCCCATCATTTCCCCCCCAGACTCGTCTTACCTTTCGGGAGCGAACCTCAACCTCTCCTGCCACTCGGCCTCTAACCCATCCCCGCAGTATTCTTGGCGTATCAATGGGATACCGCAGCAACACACACAAGTTCTCTTTATCGCCAAAATCACGCCAAATAATAACGGGACCTATGCCTGTTTTGTCTCTAACTTGGCTACTGGCCGCAATAATTCCATAGTCAAGAGCATCACAGTCTCTGCATCTGGAACTTCTCCTGGTCTCTCAGCTGGGGCCACTGTCGGCATCATGATTGGAGTGCTGGTTGGGGTTGCTCTGATATAGCAGCCCTGGTGTAGTTTCTTCATTTCAGGAAGACTGACAGTTGTTTTGCTTCTTCCTTAAAGCATTTGCAACAGCTACAGTCTAAAATTGCTTCTTTACCAAGGATATTTACAGAAAAGACTCTGACCAGAGATCGAGACCATCCTAGCCAACATCGTGAAACCCCATCTCTACTAAAAATACAAAAATGAGCTGGGCTTGGTGGCGCGCACCTGTAGTCCCAGTTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGTGGAGATTGCAGTGAGCCCAGATCGCACCACTGCACTCCAGTCTGGCAACAGAGCAAGACTCCATCTCAAAAAGAAAAGAAAAGAAGACTCTGACCTGTACTCTTGAATACAAGTTTCTGATACCACTGCACTGTCTGAGAATTTCCAAAACTTTAATGAACTAACTGACAGCTTCATGAAACTGTCCACCAAGATCAAGCAGAGAAAATAATTAATTTCATGGGACTAAATGAACTAATGAGGATTGCTGATTCTTTAAATGTCTTGTTTCCCAGATTTCAGGAAACTTTTTTTCTTTTAAGCTATCCACTCTTACAGCAATTTGATAAAATATACTTTTGTGAACAAAAATTGAGACATTTACATTTTCTCCCTATGTGGTCGCTCCAGACTTGGGAAACTATTCATGAATATTTATATTGTATGGTAATATAGTTATTGCACAAGTTCAATAAAAATCTGCTCTTTGTATAACAGAAAAA SEQ ID NO:103
基质金属蛋白酶2
>gi|113426651ref|NM_004530.1|人类基质金属蛋白酶2(明胶酶A,72kDa明胶酶,72kDa IV型胶原酶)(MMP2),mRNA|qPCR正向引物匹配[1713..1732]|qPCR反向引物匹配[1793..1775]|qPCR探针匹配[1751..1773]
TGTTTCCGCTGCATCCAGACTTCCTCAGGCGGTGGCTGGAGGCTGCGCATCTGGGGCTTTAAACATACAAAGGGATTGCCAGGACCTGCGGCGGCGGCGGCGGCGGCGGGGGCTGGGGCGCGGGGGCCGGACCATGAGCCGCTGAGCCGGGCAAACCCCAGGCCACCGAGCCAGCGGACCCTCGGAGCGCAGCCCTGCGCCGCGGACCAGGCTCCAACCAGGCGGCGAGGCGGCCACACGCACCGAGCCAGCGACCCCCGGGCGACGCGCGGGGCCAGGGAGCGCTACGATGGAGGCGCTAATGGCCCGGGGCGCGCTCACGGGTCCCCTGAGGGCGCTCTGTCTCCTGGGCTGCCTGCTGAGCCACGCCGCCGCCGCGCCGTCGCCCATCATCAAGTTCCCCGGCGATGTCGCCCCCAAAACGGACAAAGAGTTGGCAGTGCAATACCTGAACACCTTCTATGGCTGCCCCAAGGAGAGCTGCAACCTGTTTGTGCTGAAGGACACACTAAAGAAGATGCAGAAGTTCTTTGGACTGCCCCAGACAGGTGATCTTGACCAGAATACCATCGAGACCATGCGGAAGCCACGCTGCGGCAACCCAGATGTGGCCAACTACAACTTCTTCCCTCGCAAGCCCAAGTGGGACAAGAACCAGATCACATACAGGATCATTGGCTACACACCTGATCTGGACCCAGAGACAGTGGATGATGCCTTTGCTCGTGCCTTCCAAGTCTGGAGCGATGTGACCCCACTGCGGTTTTCTCGAATCCATGATGGAGAGGCAGACATCATGATCAACTTTGGCCGCTGGGAGCATGGCGATGGATACCCCTTTGACGGTAAGGACGGACTCCTGGCTCATGCCTTCGCCCCAGGCACTGGTGTTGGGGGAGACTCCCATTTTGATGACGATGAGCTATGGACCTTGGGAGAAGGCCAAGTGGTCCGTGTGAAGTATGGCAACGCCGATGGGGAGTACTGCAAGTTCCCCTTCTTGTTCAATGGCAAGGAGTACAACAGCTGCACTGATACTGGCCGCAGCGATGGCTTCCTCTGGTGCTCCACCACCTACAACTTTGAGAAGGATGGCAAGTACGGCTTCTGTCCCCATGAAGCCCTGTTCACCATGGGCGGCAACGCTGAAGGACAGCCCTGCAAGTTTCCATTCCGCTTCCAGGGCACATCCTATGACAGCTGCACCACTGAGGGCCGCACGGATGGCTACCGCTGGTGCGGCACCACTGAGGACTACGACCGCGACAAGAAGTATGGCTTCTGCCCTGAGACCGCCATGTCCACTGTTGGTGGGAACTCAGAAGGTGCCCCCTGTGTCTTCCCCTTCACTTTCCTGGGCAACAAATATGAGAGCTGCACCAGCGCCGGCCGCAGTGACGGAAAGATGTGGTGTGCGACCACAGCCAACTACGATGACGACCGCAAGTGGGGCTTCTGCCCTGACCAAGGGTACAGCCTGTTCCTCGTGGCAGCCCACGAGTTTGGCCACGCCATGGGGCTGGAGCACTCCCAAGACCCTGGGGCCCTGATGGCACCCATTTACACCTACACCAAGAACTTCCGTCTGTCCCAGGATGACATCAAGGGCATTCAGGAGCTCTATGGGGCCTCTCCTGACATTGACCTTGGCACCGGCCCCACCCCCACACTGGGCCCTGTCACTCCTGAGATCTGCAAACAGGACATTGTATTTGATGGCATCGCTCAGATCCGTGGTGAGATCTTCTTCTTCAAGGACCGGTTCATTTGGCGGACTGTGACGCCACGTGACAAGCCCATGGGGCCCCTGCTGGTGGCCACATTCTGGCCTGAGCTCCCGGAAAAGATTGATGCGGTATACGAGGCCCCACAGGAGGAGAAGGCTGTGTTCTTTGCAGGGAATGAATACTGGATCTACTCAGCCAGCACCCTGGAGCGAGGGTACCCCAAGCCACTGACCAGCCTGGGACTGCCCCCTGATGTCCAGCGAGTGGATGCCGCCTTTAACTGGAGCAAAAACAAGAAGACATACATCTTTGCTGGAGACAAATTCTGGAGATACAATGAGGTGAAGAAGAAAATGGATCCTGGCTTTCCCAAGCTCATCGCAGATGCCTGGAATGCCATCCCCGATAACCTGGATGCCGTCGTGGACCTGCAGGGCGGCGGTCACAGCTACTTCTTCAAGGGTGCCTATTACCTGAAGCTGGAGAACCAAAGTCTGAAGAGCGTGAAGTTTGGAAGCATCAAATCCGACTGGCTAGGCTGCTGAGCTGGCCCTGGCTCCCACAGGCCCTTCCTCTCCACTGCCTTCGATACACCGGGCCTGGAGAACTAGAGAAGGACCCGGAGGGGCCTGGCAGCCGTGCCTTCAGCTCTACAGCTAATCAGCATTCTCACTCCTACCTGGTAATTTAAGATTCCAGAGAGTGGCTCCTCCCGGTGCCCAAGAATAGATGCTGACTGTACTCCTCCCAGGCGCCCCTTCCCCCTCCAATCCCACCAACCCTCAGAGCCACCCCTAAAGAGATCCTTTGATATTTTCAACGCAGCCCTGCTTTGGGCTGCCCTGGTGCTGCCACACTTCAGGCTCTTCTCCTTTCACAACCTTCTGTGGCTCACAGAACCCTTGGAGCCAATGGAGACTGTCTCAAGAGGGCACTGGTGGCCCGACAGCCTGGCACAGGGCAGTGGGACAGGGCATGGCCAGGTGGCCACTCCAGACCCCTGGCTTTTCACTGCTGGCTGCCTTAGAACCTTTCTTACATTAGCAGTTTGCTTTGTATGCACTTTGTTTTTTTCTTTGGGTCTTGTTTTTTTTTTCCACTTAGAAATTGCATTTCCTGACAGAAGGACTCAGGTTGTCTGAAGTCACTGCACAGTGCATCTCAGCCCACATAGTGATGGTTCCCCTGTTCACTCTACTTAGCATGTCCCTACCGAGTCTCTTCTCCACTGGATGGAGGAAAACCAAGCCGTGGCTTCCCGCTCAGCCCTCCCTGCCCCTCCTTCAACCATTCCCCATGGGAAATGTCAACAAGTATGAATAAAGACACCTACTGAGTGGC SEQ ID NO:104
前蛋白转化酶枯草杆菌蛋白酶/kexin类型5
>gi|20336245|ref|NM_006200.2|人类前蛋白转化酶枯草杆菌蛋白酶/kexin类型5(PCSK5),mRNA|qPCR正向引物匹配[2677..2697]|qPCR反向引物匹配[2821..2801]|qPCR探针匹配[2737..2765]
CGGAGGGAGCGCTGGGAGCGAGCAAGCGAGCGTTTGGAGCCCGGGCCAGCAGAGGGGGCGCCCGGTCGCTGCCTGTACCGCTCCCGCTGGTCATCTCCGCCGCGCTCGGGGGCCCCGGGAGGAGCGAGACCGAGTCGGAGAGTCCGGGAGCCAAGCCGGGCGAAACCCAACTGCGGAGGACGCCCGCCCCACTCAGCCTCCTCCTGCGTCCGAGCCGGGGAGCATCGCCGAGCGCCCCACGGGCCGGAGAGCTGGGAGCACAGGTCCCGGCAGCCCCAGGGATGGTCTAGGAGCCGGCGTAAGGCTCGCTGCTCTGCTCCCTGCCGGGGCTAGCCGCCTCCTGCCGATCGCCCGGGGCTGCGAGCTGCGGCGGCCCGGGGCTGCTCGCCGGGCGGCGCAGGCCGGAGAAGTTAGTTGTGCGCGCCCTTAGTGCGCGGAACCAGCCAGCGAGCGAGGGAGCAGCGAGGCGCCGGGACCATGGGCTGGGGGAGCCGCTGCTGCTGCCCGGGACGTTTGGACCTGCTGTGCGTGCTGGCGCTGCTCGGGGGCTGCCTGCTCCCCGTGTGTCGGACGCGCGTCTACACCAACCACTGGGCAGTCAAAATCGCCGGGGGCTTCCCGGAGGCCAACCGTATCGCCAGCAAGTACGGATTCATCAACATAGGACAGATAGGGGCCCTGAAGGACTACTACCACTTCTACCATAGCAGGACGATTAAAAGGTCAGTTATCTCGAGCAGAGGGACCCACAGTTTCATTTCAATGGAACCAAAGGTGGAATGGATCCAACAGCAAGTGGTAAAAAAGCGGACAAAGAGGGATTATGACTTCAGTCGTGCCCAGTCTACCTATTTCAATGATCCCAAGTGGCCCAGCATGTGGTATATGCACTGCAGTGACAATACACATCCCTGCCAGTCTGACATGAATATCGAAGGAGCCTGGAAGAGAGGCTACACGGGAAAGAACATTGTGGTCACTATCCTGGATGACGGAATTGAGAGAACCCATCCAGATCTGATGCAAAACTACGATGCTCTGGCAAGTTGCGACGTGAATGGGAATGACTTGGACCCAATGCCTCGTTATGATGCAAGCAACGAGAACAAGCATGGGACTCGCTGTGCTGGAGAAGTGGCAGCCGCTGCAAACAATTCGCACTGCACAGTCGGAATTGCTTTCAACGCCAAGATCGGAGGAGTGCGAATGCTGGACGGAGATGTCACGGACATGGTTGAAGCAAAATCAGTTAGCTTCAACCCCCAGCACGTGCACATTTACAGCGCCAGCTGGGGCCCGGATGATGATGGCAAGACTGTGGACGGACCAGCCCCCCTCACCCGGCAAGCCTTTGAAAACGGCGTTAGAATGGGGCGGAGAGGCCTCGGCTCTGTGTTTGTTTGGGCATCTGGAAATGGTGGAAGGAGCAAAGACCACTGCTCCTGTGATGGCTACACCAACAGCATCTACACCATCTCCATCAGCAGCACTGCAGAAAGCGGAAAGAAACCTTGGTACCTGGAAGAGTGTTCATCCACGCTGGCCACAACCTACAGCAGCGGGGAGTCCTACGATAAGAAAATCATCACTACAGATCTGAGGCAGCGTTGCACGGACAACCACACTGGGACGTCAGCCTCAGCCCCCATGGCTGCAGGCATCATTGCGCTGGCCCTGGAAGCCAATCCGTTTCTGACCTGGAGAGACGTACAGCATGTTATTGTCAGGACTTCCCGTGCGGGACATTTGAACGCTAATGACTGGAAAACCAATGCTGCTGGTTTTAAGGTGAGCCATCTTTATGGATTTGGACTGATGGACGCAGAAGCCATGGTGATGGAGGCAGAGAAGTGGACCACCGTTCCCCGGCAGCACGTGTGTGTGGAGAGCACAGACCGACAAATCAAGACAATCCGCCCTAACAGTGCAGTGCGCTCCATCTACAAAGCTTCAGGCTGCTCGGATAACCCCAACCGCCATGTCAACTACCTGGAGCACGTCGTTGTGCGCATCACCATCACCCACCCCAGGAGAGGAGACCTGGCCATCTACCTGACCTCGCCCTCTGGAACTAGGTCTCAGCTTTTGGCCAACAGGCTATTTGATCACTCCATGGAAGGATTCAAAAACTGGGAGTTCATGACCATTCATTGCTGGGGAGAAAGAGCTGCTGGTGACTGGGTCCTTGAAGTTTATGATACTCCCTCTCAGCTAAGGAACTTTAAGACTCCAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAGTGGAACGGTTCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTCCCTGCGACCCTGAGTGCAGTGAGGTTGGCTGTGACGGGCCAGGACCAGACCACTGCAATGACTGTTTGCACTACTACTACAAGCTGAAAAACAATACCAGGATCTGTGTCTCCAGCTGCCCCCCTGGCCACTACCACGCCGACAAGAAGCGCTGCAGGAAGTGTGCCCCCAACTGTGAGTCCTGCTTTGGGAGCCATGGTGACCAATGCATGTCCTGCAAATATGGATACTTTCTGAATGAAGAAACCAACAGCTGTGTTACTCACTGCCCTGATGGGTCATATCAGGATACCAAGAAAAATCTTTGCCGGAAATGCAGTGAAAACTGCAAGACATGTACTGAATTCCATAACTGTACAGAATGTAGGGATGGGTTAAGCCTGCAGGGATCCCGGTGCTCTGTCTCCTGTGAAGATGGACGGTATTTCAACGGCCAGGACTGCCAGCCCTGCCACCGCTTCTGCGCCACTTGTGCTGGGGCAGGAGCTGATGGGTGCATTAACTGCACAGAGGGCTACTTCATGGAGGATGGGAGATGCGTGCAGAGCTGTAGTATCAGCTATTACTTTGACCACTCTTCAGAGAATGGATACAAATCCTGCAAAAAATGTGATATCAGTTGTTTGACGTGCAATGGCCCAGGATTCAAGAACTGTACAAGCTGCCCTAGTGGGTATCTCTTAGACTTAGGAATGTGTCAAATGGGAGCCATTTGCAAGGATGCAACGGAAGAGTCCTGGGCGGAAGGAGGCTTCTGTATGCTTGTGAAAAAGAACAATCTGTGCCAACGGAAGGTTCTTCAACAACTTTGCTGCAAAACATGTACATTTCAAGGCTGAGCAGCCATCTTAGATTTCTTTGTTCCTGTAGACTTATAGATTATTCCATATTATTAAAAAGAAAAAAAAAAGCCAAAAAG SEQ ID NO:105
羧肽酶N,多肽2,83kDa
>gi|18554966|ref|NM_087358.1|人类羧肽酶N,多肽2,83kDa(CPN2),mRNA
ATGGGTTGTGACTGCTTCGTCCAGGAGGTGTTCTGCTCAGATGAGGAGCTTGCCACCGTCCCGCTGGACATCCCGCCATATACGAAAAACATCATCTTTGTGGAGACCTCGTTCACCACATTGGAAACCAGAGCTTTTGGCAGTAACCCCAACTTGACCAAGGTGGTCTTCCTCAACACTCAGCTCTGCCAGTTTAGGCCGGATGCCTTTGGGGGGCTGCCCAGGCTGGAGGACCTGGAGGTCACAGGCAGTAGCTTCTTGAACCTCAGCACCAACATCTTCTCCAACCTGACCTCGCTGGGCAAGCTCACCCTCAACTTCAACATGCTGGAGGCTCTGCCCGAGGGTCTTTTCCAGCACCTGGCTGCCCTGGAGTCCCTCCACCTGCAGGGGAACCAGCTCCAGGCCCTGCCCAGGAGGCTCTTCCAGCCTCTGACCCATCTGAAGACACTCAACCTGGCCCAGAACCTCCTGGCCCAGCTCCCGGAGGAGCTGTTCCACCCACTCACCAGCCTGCAGACCCTGAAGCTGAGCAACAACGCGCTCTCTGGTCTCCCCCAGGGTGTGTTTGGCAAACTGGGCAGCCTGCAGGAGCTCTTCCTGGACAGCAACAACATCTCGGAGCTGCCCCCTCAGGTGTTCTCCCAGCTCTTCTGCCTAGAGAGGCTGTGGCTGCAACGCAACGCCATCACGCACCTGCCGCTCTCCATCTTTGCCTCCCTGGGTAATCTGACCTTTCTGAGCTTGCAGTGGAACATGCTTCGGGTCCTGCCTGCCGGCCTCTTTGCCCACACCCCATGCCTGGTTGGCCTGTCTCTGACCCATAACCAGCTGGAGACTGTCGCTGAGGGCACCTTTGCCCACCTGTCCAACCTGCGTTCCCTCATGCTCTCATACAATGCCATTACCCACCTCCCAGCTGGCATCTTCAGAGACCTGGAGGAGTTGGTCAAACTCTACCTGGGCAGCAACAACCTTACGGCGCTGCACCCAGCCCTCTTCCAGAACCTGTCCAAGCTGGAGCTGCTCAGCCTCTCCAAGAACCAGCTGACCACACTTCCGGAGGGCATCTTCGACACCAACTACAACCTGTTCAACCTGGCCCTGCACGGTAACCCCTGGCAGTGCGACTGCCACCTGGCCTACCTCTTCAACTGGCTGCAGCAGTACACCGATCGGCTCCTGAACATCCAGACCTACTGCGCTGGCCCTGCCTACCTCAAAGGCCAGGTGGTGCCCGCCTTGAATGAGAAGCAGCTGGTGTGTCCCGTCACCCGGGACCACTTGGGCTTCCAGGTCACGTGGCCGGACGAAAGCAAGGCAGGGGGCAGCTGGGATCTGGCTGTGCAGGAAAGGGCAGCCCGGAGCCAGTGCACCTACAGCAACCCCGAGGGCACCGTGGTGCTCGCCTGTGACCAGGCCCAGTGTCGCTGGCTGAACGTCCAGCTCTCTCCTTGGCAGGGCTCCCTGGGACTGCAGTACAATGCTAGTCAGGAGTGGGACCTGAGGTCGAGCTGCGGTTCTCTGCGGCTCACCGTGTCTATCGAGGCTCGGGCAGCAGGGCCCTAGTAGCAGCGCATACAGGAGCTGGGGAAGGGGGCTTTGGGGCCTGCCCACGCGACAGGTAGGGGCGGAGGGGAGCTGAGTCTCCGAAGCTTGGCTTT SEQ ID NO:106
透明质酸和蛋白聚糖连接蛋白4
>gi|30794471|ref|NM_023002.1|人类透明质酸和蛋白聚糖连接蛋白4(HAPLN4),mRNA
CGGGGGCCGCGCGGGCAAGATGGTGTGCGCTCGGGCGGCCCTCGGTCCCGGCGCGCTCTGGGCCGCGGCCTGGGGCGTCCTGCTGCTCACAGCCCCTGCGGGGGCGCAGCGTGGCCGGAAGAAGGTCGTGCACGTGCTGGAGGGTGAGTCGGGCTCGGTAGTGGTACAGACAGCGCCTGGGCAGGTGGTAAGCCACCGTGGTGGCACCATCGTCTTGCCCTGCCGCTACCACTATGAGGCAGCCGCCCACGGTCACGACGGCGTCCGGCTCAAGTGGACAAAGGTGGTGGACCCGCTGGCCTTCACCGACGTCTTCGTGGCACTAGGCCCCCAGCACCGGGCATTCGGCAGCTACCGTGGGCGGGCTGAGCTGCAGGGCGACGGGCCTGGGGATGCCTCCCTGGTCCTCCGCAACGTCACGCTGCAAGACTACGGGCGCTATGAGTGCGAAGTCACCAATGAGCTGGAAGATGACGCTGGCATGGTCAAGCTGGACCTGGAAGGCGTGGTCTTTCCCTACCACCCCCGTGGAGGCCGATACAAGCTGACCTTCGCGGAGGCGCAGCGCGCGTGCGCCGAGCAGGACGGCATCCTGGCATCTGCAGAACAGCTGCACGCGGCCTGGCGCGACGGCCTGGACTGGTGCAACGCGGGCTGGTTGCGCGACGGCTCAGTGCAATACCCCGTGAACCGGCCCCGGGAGCCCTGCGGCGGCCTGGGGGGGACCGGGAGTGCAGGGGGCGGCGGTGATGCCAACGGGGGCCTGCGCAACTACGGGTATCGCCATAACGCCGAGGAACGCTACGACGCCTTCTGCTTCACGTCCAACCTGCCGGGGCGCGTGTTCTTCCTGAAGCCGCTGCGACCTGTACCCTTCTCCGGAGCTGCGCGCGCGTGTGCTGCGCGTGGCGCGGCCGTGGCCAAGGTGGGGCAGCTGTTCGCCGCGTGGAAGCTGCAGCTGCTAGACCGCTGCACCGCGGGTTGGCTGGCCGATGGCAGTGCGCGCTACCCCATCGTGAACCCGCGAGCGCGCTGCGGAGGCCGCAGGCCTGGTGTGCGCAGCCTCGGCTTCCCGGACGCCACCCGACGGCTCTTCGGCGTCTACTGCTACCGCGCTCCAGGAGCACCGGACCCGGCACCTGGCGGCTGGGGCTGGGGCTGGGCGGGCGGCGGCGGCTGGGCAGGGGGCGCGCGCGATCCTGCTGCCTGGACCCCTCTGCACGTCTAGGCTGGGAGTAGGCGGACAGCCAGGGCGCTTGACCACTGGTCTAGAGCCCTGTGGTCCCCTGGAGCCTGGCCACGCCCTTGAAGCCCTGGACACTGGCCACATTCCCTGTGGTCCCTTACAAACTAACTGTGCCCCTGGGGTCCCTGAAGACTGGCTAGTCCTGGCAGAACAGTACTTTGGAGTTCCCTGGAGCCTGGCCAGCCCTCACCTCTTCTGGATAGAGGATTCCCCCAACTCCCCAACTTTCTCCATGAGGGTCACGCCCCCTGAGGACCTCAGGAGGCCAGCAGAACCCGCAGGCTCCTGAAGACTGGCCACGCCTCCTGAGACCACTTGGAAACAGACCAACTGCCCCCGTGGTCGCCTGGTGGCTGGACCCCCGGGATTGACTAGAGACCGGCCGTACACCTTCTGCATCTCACTGGAGACTGAACACTAGTCCCTTGCGGTCACGTGGGACACTGGGCGCCTCCTCCTCCCCCTCCTCCTCACCTGGAGAGACTACAGGAACTTCAGGGTCACTCCCCGTGGTCACATGGAGGTTGTGGGCCGAGGCGCTTATTTTCCCTTATGGTGACCTGAGTCCTGGAGACTCCCATTCTCCCCCTCTCCCTGAGAGTCCCCTGCAGTTTCTGGGTAACAGGGCACACCCCTCTAGTTTCATGGGCGAGCACCCCCATCTGCCACCTCAGACTGACACACAGCCAGCTGGCTCACTTACTGGGGGCCACGTCCCACCCCTCAGATATTTCTTTGAAGGGAGAGCAAACCCACCCTGTCCTCTGACGTCCCTTTCCCAACTGTCACCAAACAGACCATCTTCCCAGGCCTGGGGACCGGTAAGATCCATGTCACTAGTTATGCAGAGCAGTTGCCTTGGGTCCCACTGTCACCAAGGCAACCAGTCCTGCTGCTACCTGTCACCTAGAGTCACACACCCCTTCCCTCATCAGGCACACCCATGAAGACAGTGCCTCCCTCCTCCAGCTGTAACCATGGATACCACACATTTCTCATCTCATTGGCCCCCACCCCAGAGACCTCCACCTCAACTTCTGGCTGTCCCTACCCTGACTCACCGCCATGGAGATCACCCTCCCCGAAGCTGTCGCCAGGGTGACCCAACATCCAGTTCTCCGGCTCTCACCATGGAAACAAACTGTCCCTGTCCCCAGGCCCACTCCAGTTCCAGACCACCCTCCATGCTCCACCCCCAGGCGGTTTGGACCCCACCACTGTTGCCATGGTGACCAAACTCTGGAGTCCGAGGTAACAGAACACCTGTCCCCCTAGGCTTTTCCTTGTGGACAACGGGGCCCTGTTCACCAAGCTGTTGCCATAGAGACTGTCAACGTTGTCCTCATGACAACCAGACTTCCAGTTCTCAGGAACTTCTCATTGTGGGCCAGAAGTCCTGGGTGCCTCCTACTAGGGCTACCCTACTGCACCCCATCAGGGGCCTGATGGCTGCCCCTTCCCCAGACAGGGCTGGACTTCTGGAGCTGCTAAGCCACCCTCCGTTTGCACGTTAACTCTATGCCGGATAGCAGCTGTGCACGAGACAATCTTGCAACACCCGGGCATGTTTGTCGTCGTCCTACAAATGAGGAAACCGAGCCTATGGCGTGCCCTGGTCTGTTGAGATATGCAAGCACTGAGCTCCTCTTTTGTCCTCTGAGACCCCATCTCCATTCTCACCCAGTTCCTCTCTCCTTCCCTGACCCCCACCCACATTTCCCTCCTTAGAGATCCAGGAGGGATGGAATGTTCTTTAAAATTCAACACCCACCAGGCTCTAAGCGGCGATCTGTGCTAAGAGGTCAGGACCCAGCCGAAGTCCTCGGCGTTGACAGGCAGCTGGGGGGACATGATCCATGGACAAGGCCATCCCGGCCGTGGGAGACCCCAGTCCCGAAGTCTTGCCTGCAGGAGTACTGGGGTCCCCCTGGGGCCCTCTTTACTGTCACGTCATCTCTAGGAAACCTATCTCTGAGTTTTGGGACCAGGTCGGTTTGGGTTTGAATTCTGCCTCTTCTTGCTCACTGTGTGACCAAGTGACAAACTCCTTCTGAACCTGTGTTCTCCCACTGTACCAGGGCTGTTCTGTGGTCCCCGTGAGTGCCAAGCATACAGTAGGGGCTCAATAAATCCTTGT SEQ ID NO:107
免疫组织化学
从组织块切下8μM厚的冰冻切片并粘贴于APES玻片上。将组织切片放入丙酮中固定10分钟后空气干燥。然后玻片在含有0.3%过氧化氢的甲醇中浸润10分钟,再用磷酸缓冲盐溶液(PBS)冲洗。通过用20%的适当动物血清孵育玻片来封闭非特异性结合位点,再次用PBS冲洗。用含有1%血清的PBS稀释初级抗体,然后滴加到玻片上。孵育1小时后,再次用PBS冲洗玻片,然后用次级抗体再孵育1小时。PBS最后冲洗之后,使用溶解于Tris缓冲盐溶液(TBS)的二氨基联苯胺四盐酸盐检测次级抗体,再用TBS和水冲洗。然后玻片经苏木素复染,并置于光学显微镜下观察。
在某些实施方案中,可以使用基于本发明癌症标记物的染色对胃肿瘤进行原位(in situ)定位。至少一种标记物可形成淀粉样结构从而能用刚果红或等效的、非特异性的淀粉样蛋白染色剂进行显色。
体液中胃癌标记物的检测
在几个实施方案中,可以对从血液、血浆、血清、诸如使用腹膜灌洗获得的腹膜液或其它体液如尿液、淋巴液、脑脊液、胃液或者粪便样品中获得的样品如愿地进行GTM分析。
一般而言,用于分析这些液体中的寡核苷酸、蛋白质和肽的方法是本领域技术中已知的。寡核苷酸的检测可以采用杂交方法如Northern印迹、Southern印迹或微阵列方法或者qPCR进行。检测蛋白质的方法包括例如酶联免疫吸附测定(ELISA)、具有抗体的蛋白质芯片、悬浮珠放射免疫测定(RIA)、Western印迹和凝集素结合试验。然而,为了说明的目的,可以使用夹心法酶联免疫吸附测定(ELISA)对液体中GTM水平进行定量检测。对于血浆分析,在微量滴定板的孔中加入5μL的适当稀释样品的等分试样或连续稀释的标准GTM和75μL结合有过氧化物酶的抗人GTM抗体。30℃孵育30分钟之后,用含0.05%Tween 20的磷酸缓冲盐溶液(PBS)洗涤各孔以除去未结合的抗体。然后,将GTM和抗GTM抗体的结合复合物用含有H2O2的邻苯二胺于30℃孵育15分钟。加入1MH2SO4终止反应,并用微量滴定板读板机测定492nm处的吸光度。
应该意识到,抗GTM抗体可以是单克隆抗体或者多克隆抗血清。还应该意识到,任何其它的体液能够进行适当的研究。
已知一些标记物存在于血浆或血清中。这些标记物包括骨桥蛋白(Hotte等人,Cancer 95(3):507-510(2002))、前列腺特异性抗原(Martin等人,Prostate Cancer Prostatic Dis.(2004年3月9日)(Pub Med No:PMID:15007379))、甲状腺球蛋白(Hall等人,Laryngoscope 113(1):77-81(2003);Mazzaferri等人,J.Clin.Endocrinol.Metab.88(4):1433-14421(2003))、基质金属蛋白酶2和9(Kuo等人,Clin.Chem.Acta.294(1-2):157-168(2000))、CEA和TIMP1(Pellegrini等人,Cancer Immunol.Immunother.49(7):388-394(2000))。因此,由于上述标记物中的一些对于GTM也是有用的标记物,所以对它们进行检测和定量的血浆、血清或其它体液分析法早已经是可得的。因为许多蛋白质或者是(1)由细胞分泌、或者是(2)从细胞膜脱落、或者是(3)处于细胞死亡的细胞丢失的,所以其它GTM也可存在于体液如血浆、血清等中。因此,在本发明的实施方案中,对方便获得的样品进行GTM检测是有用且合意的,并能作为胃癌诊断的基础。
Western分析
使用TriReagent和盐酸胍提取法从胃组织中抽提出蛋白质。从TriReagent提取RNA获得的非水相与1.5倍体积乙醇混合并离心去除DNA和OCT介质。将0.5mL上清液与0.75mL异丙醇混合,室温孵育10分钟,然后离心。沉淀物用1mL含0.3M盐酸胍的95%乙醇洗涤3次,再单用乙醇洗涤1次,然后重悬于50μL的1%SDS中。
采用标准方法,将蛋白质定量并进行SDS聚丙烯酰胺凝胶电泳。简言之,按照标准方法学使用BioRad(trans-biot电转槽)将分离的蛋白质转移至PVDF膜上。然后用含有脱脂奶粉的溶液封闭30分钟,再用初级抗体室温孵育2小时。洗涤之后,加次级抗体室温孵育1小时。最后一次洗涤之后,用ECL检测系统(Amersham Biosciences)显色所结合抗体。
通过用已知方法准备血清样品,然后或者使用寡核苷酸探针或者使用抗目的蛋白质的抗体对血清样品进行分析,从而完成血清中标记物的检测。包括Western印迹分析在内的免疫印迹对于确定备选表达的蛋白质在血清中是否存在是特别有用的。另外,包括腹膜液、脑脊液等在内的其它体液中可能包含标记物。有用的标记物没有必要是生理学意义上被分泌的。相反地,标记物蛋白质或基因进入血清的任何机制都能有效产生可检测的、可量化水平的标记物。因此,可溶性蛋白质从细胞中正常分泌、膜蛋白从质膜脱落、可变剪接形式的mRNA或从其表达的蛋白质的分泌、细胞死亡(或者凋亡细胞)能够产生足够水平的有用标记物。对于血清标记物作为多种癌症类型的诊断和/或治疗效果评价工具的用途得到越来越多的支持。
Yoshikawa等人(Cancer Letters,151:81-86(2000))描述了胃癌患者血浆中的基质金属蛋白酶组织抑制剂1。
Rudland等人(Cancer Research 62:3417-3427(2002))描述了作为人乳腺癌转移相关蛋白的骨桥蛋白。
Buckhaults等人(Cancer Research 61:6996-7001(2002))描述了结肠直肠肿瘤中的某些分泌的和细胞表面表达的基因。
Kim等人(JAMA 287(13):1671-1679(2002))描述了作为潜在的卵巢癌诊断生物标记物的骨桥蛋白。
Hotte等人(AJ.American Cancer Society 95(3):507-512(2002))描述了作为人体液中可检测蛋白质以及与某些恶性肿瘤相关的骨桥蛋白。
Martin等人(Prostate Cancer Prostatic Dis.2004年3月9日(PMID:15007379))(摘要)描述了人激肽释放酶2、前列腺特异性抗原(PSA)和游离PSA作为检测前列腺癌的标记物的用途。
Hall等人(Laryngoscope 113(1):77-81(2003)(PMID:12679418))(摘要)描述了甲状腺癌患者血清甲状腺球蛋白的预测值。
Mazzaferri等人(J.Clin.Endocrinol.Metab.88(4):1433-1441(2003))(摘要)描述了作为甲状腺癌患者潜在监测方法的甲状腺球蛋白。
Whitley等人(Clin.Lab.Med.24(1):29-47(2004))(摘要)描述了作为甲状腺癌血清标记物的甲状腺球蛋白。
Kuo等人(Clin.Chim.Acta.294(1-2):157-168(2000))(摘要)描述了HCV和HBV感染患者的血清基质金属蛋白酶2和9。
Koopman等人(Cancer Epidemiol.Biomarkers Prev 13(3):487-491(2004))(摘要)描述了作为胰腺癌生物标记物的骨桥蛋白。
Pellegrini等人(Cancer Immunol.Immunother.49(7):388-394(2000))(摘要)描述了作为侵袭前结肠直肠癌标记物的可溶性癌胚抗原和TIMP1的测定。
因此,我们已经鉴定了对于研发检测和评价胃癌的试剂、装置和试剂盒有用的许多基因和/或蛋白质。可以单独或联合使用一种或多种胃癌标记物以便提供用于胃癌检测的可靠分子检验。
实施例
本文描述的实施例其目的是为说明本发明的实施方案。其它的实施方案、方法和分析类型处于分子诊断技术领域中普通技术人员所掌握的范围内,从而不必在此详细描述。可以将本技术领域范围内的其它实施方案看作是本发明的一部分。
实施例1:胃恶性肿瘤标记物的鉴定
图2描述了使用经上述标准所选择的38种胃肿瘤标记物进行研究的结果列表。图2包括基因的符号(“符号”)、MWG oligo号、NCBI mRNA参考序列号、蛋白质参考序列号、肿瘤和非肿瘤基因表达之间的变化倍数、在微阵列分析中相对于其它基因的变化倍数的等级、原始未调整的Student′s t-检验结果、经Bonferroni调整的p值结果和两个样品的Wilcoxon检验结果。
这34种基因的中值变化倍数(肿瘤组织:非恶性肿瘤组织)范围是1.6-7,并且变化倍数等级的中值变化范围为-16,995-25,783。变化倍数秩中最大的可能变化是-29,718。对于每一种显示的标记物,它们作为癌症标记物的特异性具有极其高的统计学意义。一般来说,Bonferroni调整的p值全部低于10-6或更低,这提示使用这些标记物进行的诊断与胃癌的相关性非常高。
三种半胱氨酸蛋白酶抑制剂(CST1、CST2和CST4)高度同源并且在微阵列上为同一寡核苷酸,除非另外说明,将它们集体称作“CST1,2,4”。
通过使用SMART软件包(欧洲分子生物实验室)预测,图2中描述的所有蛋白质均具有信号肽。已知信号肽能引导合成的蛋白质到达细胞外区室,因而分泌至组织液,其可以从组织液进入血液。事实上,本发明的一些蛋白质已经在血清中检测到。
图2中描述的每一种基因显示了强度等级大于阵列中对应于CEA的2个寡核苷核的变化,CEA为在监控胃癌进展的的临床实践中最常用的标记物。
实施例2:qPCR分析
对于图3中显示的基因亚类,使用qPCR获得基因表达的更加灵敏和精确的定量。在从46份肿瘤样品和49非恶性肿瘤样品得到的RNA中分析了通过微阵列分析(图2)鉴定的23个基因,结果见图3。图3包括基因符号、在癌组织和正常组织之间的变化倍数中值,以及表达高于非肿瘤样品中表达水平第95百分位数的肿瘤样品的百分比(%)。由于高(>75%)的正常细胞污染、高程度的坏死(>40%)或者在微阵列上杂交信号较差,将12份肿瘤样品和9份正常样品排除在外,不进行分析。这23个基因的倍数变化中值范围从3倍至525倍(图3)。
对于≥90%的情况,基因ASPN、CST1,2,4、LOXL2、TIMP1、SPP1、SFRP4、INHBA、THBS2和SPARC在肿瘤中表达水平高于在非恶性肿瘤中表达范围的第95百分位数(图3)。对于剩余的基因,在>50%的样品中,其在肿瘤中的表达高于第95百分位数。每一个肿瘤中至少7个基因的过表达高于第95百分位数,这表明标记物组合将全面覆盖所有胃肿瘤。
实施例3:使用qPCR对微阵列数据的验证
使用24种基因的探针对肿瘤样品和非恶性肿瘤样品进行定量实时PCR(qPCR)来验证微阵列数据。在所有研究的24种基因中,有20种基因显示了两种技术之间具有强烈的相关性。图4a-4d显示了这些分析中的四个分析,这些图描述了使用微阵列和qPCR方法检测四种所选癌症标记物的相对表达图。对于图4中的每一个图,横轴代表微阵列检测基因表达的变化倍数的log2数值,而纵轴代表qPCR检测基因表达的变化倍数的log2数值。我们发现,如由两种方法之间的协变关系所表明,这两种方法之间具有强烈的相关性。这种强烈的相关性提示微阵列和qPCR的变化倍数分析是检测胃癌标记物基因表达变化的合适方法,并且因此能用作精确的、敏感的筛选方法。从图4a-4d还可以理解qPCR比微阵列方法能更灵敏地检测表达的变化。因此,在尤其需要早期检测的情况下,qPCR特别有用。
图5a-5w描述了对于正常组织(未填充直条)和肿瘤组织(黑色直条),比较一系列23种基因中每一种基因表达的观测频率(纵轴)和此基因表达变化倍数的log2数值(横轴)关系的柱状图。我们意外发现:这23种基因中的每一种基因在正常组织和肿瘤组织之间的频率分布基本上是分离的,这如频率分布曲线之间的低重叠程度所反映。例如,图5b描述了CST1,2,4的结果,其中只有一份正常样品的表达水平在肿瘤表达水平范围内。在其它情况中(例如,图5n;PRS11),每一个频率分布曲线相对狭窄并有一定程度的重叠。然而,甚至对于此标记物,变化倍数log2数值的中值显示基因表达量间基本上是分离的。在其它情况中(例如,图5a;ASPN),尽管频率分布曲线有些重叠,但在正常样品和肿瘤样品之间的表达倍数log2数值中值明显分离。
图6描述了与正常样品相比,肿瘤样品中显示表达明显增加(“过表达”)的基因数量(纵轴)和各个测试样品之间关系的柱状图。在每一情况中,肿瘤样品表现为的多重基因表达水平升高。在E123样品中,表达升高的基因数量最低,为7个基因。此发现说明,在多重基因相对正常组织过表达的情况下,癌症检测的可靠性非常高,从而使癌症诊断更加确定。然而,在一些情况中,单一标记物基因的表达升高足以对癌症做出诊断。
对于与血清标记物CEA(当前最常用于胃癌检测)的先前比较是基于肿瘤样品和正常样品之间微阵列数据强度等级的差别。使用标记物和CEA的qPCR数据验证该比较。
图7a-7c描述了与肿瘤标记物基因CEA的表达相比,在各个肿瘤样品和非恶性肿瘤样品中标记物的相对log2表达(与参考RNA制品相比)图。CEA是当前最常用的监测胃癌进展的血清标记物。零点定义为每一种标记物的正常表达中值。可以看到CEA基因(CEACAM5)的表达在肿瘤样品和正常样品之间具有广泛重叠。而在胃癌标记物ASPN、CSPG2、CST1,2,4、IGFBP7、INHBA、LOXL2、LUM、SFRP4、SPARC、SPP1、THBS2、TIMP1、adlican、LEPRE1和EFEMP2中该种重叠明显减少。对于图7b-7c中的其它标记物ASAH1、SFRP2、GGH、MMP12、KLK10、TG、PRSS11和TGFBI,在肿瘤组织中表达范围和非恶性肿瘤组织中表达范围之间的重叠大于上述标记物的表达重叠情况,但仍然低于CEA的表达重叠情况,这说明本文描述的所有新标记物在定量上好于CEA,因此能提供更加可靠的诊断。
为了把不同组织处理的影响减到最低,使用来自同一患者的肿瘤组织和非恶性肿瘤组织样品的qPCR数据来计算肿瘤:正常(非恶性肿瘤)变化倍数。这样的配对分析校正了基因在不同个体表达的背景水平的差异,并将组织处理对RNA定量的影响降到最低。例如,如果将切除的胃在室温下放置1小时,则正常样品和肿瘤样品中转录物的降解程度相同。
图8总结了通过qPCR测定的标记物的T:N表达水平,但是使用了来自同一个体的配对数据(即肿瘤样品和非恶性肿瘤样品)。图8还包括了图3中未包括的六种基因的表达数据。这些额外研究基因是MMP2、CGR11、TGFB1、PCSK5、SERPINB5和SERPINH1。鉴定信息和探针显示于图1和图2。图8显示了29种胃癌标记物在这些40位患者“配对”样品中的T:N变化倍数中值和T:N变化倍数最大值。在29种标记物中有27种标记物T:N变化倍数中值大于或等于在先技术标记物CEA的T:N变化倍数中值。全部29种标记物具有较高的、在肿瘤样品中的表达超过正常样品中的表达的配对样品百分比。
图9a-9d描述了来自同一个体肿瘤组织和正常组织的数据的散点图。每一个点代表了标记物在患者肿瘤组织中表达相对于在非肿瘤组织中表达的变化倍数。所有研究的标记物均比CEA具有更好的区别肿瘤组织和非肿瘤组织的能力。CST1,2,4、ASPN和SFRP4三种标记物能够对配对的肿瘤和正常样品进行100%的区别。即这些标记物在每一个肿瘤组织中的表达高于来自同一个体的相应非肿瘤组织。在其它许多标记物中,例如Adlican、CSPG2、EFEMP2、IGFBP7、INHBA、LOXL2、LUM、SERPINH1、SPARC、SPP1、TGFbI、THBS2和TIMP1,每一种标记物在肿瘤组织中的表达低于非肿瘤组织的个别点仅有2个或3个。因此,对于这些标记物而言,在任何一组配对肿瘤组织和非肿瘤组织中可能产生假阴性的可能性相对低(例如,40份中有3份为阴性或7.5%的假阴性,40份中有2份为阴性或5%的假阴性,40份中有1份为阴性或2.5%的假阴性)。因此,即使使用上面刚刚列举的其它标记物,使用来自同一患者的多个样品也能产生可靠的诊断信息。
上文显示了这些标记物的基因序列,以及用来检测它们的引物和探针的位置。
为了确定标记物基因过表达是否不依赖于胃肿瘤的分期,将配对T:N变化倍数的log2数值对肿瘤分期作图(图10a-10ad)。观察发现,对于图8中列举的26种标记物在肿瘤中的表达不具有肿瘤分期依赖性。这些标记物在肿瘤早期和肿瘤晚期的过表达情况类似。然而,KLK10在肿瘤1期和2期的过表达更一致,而PCSK5和SERPINB5在肿瘤4期的过表达更一致。因此KLK10、PCSK5和SERPINB5能用于确定胃肿瘤的时期。
在类似的分析中,将配对T:N变化倍数的log2数值对肿瘤Lauren分类(或者为扩散型或者为肠型)作图。图11a-11ab显示不管肿瘤类型是肠型(I)或是扩散型(D),29种GTM中的每一个能够区别肿瘤组织和非肿瘤组织。
实施例4:多重标记物的使用
如上面所描述,某些标记物表现出具有在100%的样品中区别肿瘤组织和非肿瘤组织的能力。可以将同为上述的其它标记物组合使用,以便实现非常高程度地区分肿瘤组织和非肿瘤组织。图12描述了三种标记物SERPINH1、CST1,2,4和INHBA表达的三维图,其表示为在一系列胃肿瘤样品和非恶性肿瘤胃样品中T:N变化倍数的log2数值。两组样品发生完全分离。
通过总结于图13的统计学分析进一步说明了使用标记物的组合成功区别肿瘤样品和非肿瘤样品的可靠性。此分析比较了使用qPCR产生的来自配对的肿瘤和非恶性肿瘤样品基因表达数据的正态分布,分析显示增加用来区别肿瘤样品和非恶性肿瘤样品的标记物数量对检测敏感性(将特异性固定在95%)的影响。尽管此分析中29种标记物(如图8所示)在单独应用时很少具有大于90%、95%或99%的敏感性,但是两种或三种标记物的组合能够达到使用大量组合所能达到的高敏感性。例如,三种标记物的50种组合能以≥99%的敏感性和≥95%的特异性区别肿瘤样品和非恶性肿瘤样品。
实施例5:胃肿瘤标记物蛋白质的检测
在更进一步的实施方案中,GTM蛋白质可以作为诊断的基础来检测。在某些情况下,特殊样品(如不含细胞的样品)中的mRNA浓度很难使用微阵列或qPCR方法来检测基因表达的提高。因此,在某些实施方案中,使用抗完整蛋白质、蛋白质片段(肽)或蛋白质核心的抗体实现GTM蛋白质的检测。检测和定量蛋白质和肽表达的方法在本技术领域是已知的,并且包括依靠抗蛋白质或肽的特异性抗体的方法。单克隆抗体和多克隆抗血清的制备可以使用本技术领域众所周知的方法进行,因而不需要在本文中进一步描述。
为了证明GTM蛋白质能用来区分肿瘤组织和非肿瘤组织,得到了商品化的抗SPARC抗体(R&D Systems;目录号AF941)、抗THBS2抗体(Santa Cruz Biotechnology Inc;目录号sc-7655)、抗CSPG2抗体(Calbiochem;目录号428060)和抗IGFBP7抗体(R&D Systems;目录号AF1334)。另外的抗半胱氨酸蛋白酶抑制剂SN肽序列50-66(C)FAISEYNKATKDDYYRR(SEQ ID NO:108)的多克隆抗体在家兔中产生。
在肿瘤胃组织和非恶性肿瘤胃组织的免疫组织化学分析或Western分析中使用这些抗体。这些标记物中的每一个在蛋白质水平显示了强的肿瘤:正常差异。这证实在RNA水平所观察到的这些基因的高表达同样也发生在蛋白质水平。
图14显示了使用抗由SPARC、CST1(半胱氨酸蛋白酶抑制剂SN)、IGFBP7和THBS2所编码蛋白质的抗体对两份配对从肿瘤组织和非恶性肿瘤组织中提取的总蛋白进行的Western印迹分析。对于每一个标记物,在肿瘤样品中的信号明显高于非肿瘤样品。
抗半胱氨酸蛋白酶抑制剂SN抗体检测到三条主要条带,其分别对应大约34、45和65kDa的分子量。图14显示最低分子量条带。该蛋白质种类大于对照半胱氨酸蛋白酶抑制剂SN蛋白质,提示肿瘤产生的蛋白质已经经过翻译后修饰或多聚化。图14说明:无论引起CST蛋白质分子量差异的机制如何,CST在非肿瘤组织中低表达,但是在肿瘤来源蛋白质印迹中容易观察到CST表达。
图14还显示SPARC蛋白质在肿瘤组织中以高于非肿瘤组织的程度相当大地表达。SPARC蛋白质的凝胶迁移率慢于血清中检测到的该蛋白质形式(图15),这还提示恶性胃肿瘤细胞产生的蛋白质出现不同的翻译后修饰。不管引起任何此种修饰的机制如何,关于SPARC在肿瘤组织相对非恶性肿瘤组织过表达的这一发现提示SPARC是一种有用的蛋白质标记物。同样地,IGFBP7和THBS2在肿瘤组织中相对非恶性肿瘤组织过表达。
使用抗由CSPG2(多功能蛋白聚糖)和CST1(半胱氨酸蛋白酶抑制剂SN)所编码蛋白质的抗体对肿瘤组织和非恶性肿瘤组织进行免疫组织化学分析。使用抗多功能蛋白聚糖抗体对组织的免疫组织化学分析鉴定出在肿瘤组织的细胞外基质有强染色,但在非恶性肿瘤组织中没有。使用抗半胱氨酸蛋白酶抑制剂SN抗体,能够在肿瘤细胞外周区域观察到强染色。在非恶性肿瘤细胞中,使用该抗体的染色较弱,并只在组织的粘模表面和胃小凹内层(lining)观察到。这说明在非恶性肿瘤细胞中,半胱氨酸蛋白酶抑制剂SN蛋白质被指引出细胞至粘模表面而不进入细胞外间隙。因此,不但半胱氨酸蛋白酶抑制剂SN蛋白质在肿瘤组织中的产生量高于非恶性肿瘤组织,而且与非恶性肿瘤组织产生的蛋白质不同,肿瘤组织产生的半胱氨酸蛋白酶抑制剂SN与组织的脉管系统直接接触。为了扩大这些观察,使用单克隆抗体(R&D Systems;目录号MAB1285)从胃癌细胞系AGS上清液中免疫沉淀半胱氨酸蛋白酶抑制剂SN(图16)。在上清液中检测到大量的半胱氨酸蛋白酶抑制剂SN,这证实该蛋白质由胃上皮细胞产生并分泌。
实施例6:血清中肿瘤标记物的分析
对于能用于快速筛选的标记物,需要标记物在血清中达到足以检测的水平。在图8中描述的某些蛋白质能够从胃癌分泌入血达到可检测的水平。TIMP1是一个已知的从胃肿瘤分泌入血达到可检测水平的标记物。然而,如果蛋白质是从粘模表面以外的任何细胞表面分泌或脱落,那么它将与间质液接触。该蛋白质能从间质液通过毛细管直接进入血流或经过淋巴系统进入血流。因此,任何脱落的GTM将存在于血液中。以前已经描述过骨桥蛋白、甲状腺球蛋白以及MMP和激肽释放酶的家族成员在上皮癌患者血清中浓度升高,而在胃癌患者血清中不升高。然而,以前已经观察到TIMP1在胃癌患者血清中有所升高。这些发现提示本研究中标记物的选择标准(即分泌的蛋白质在肿瘤组织中过表达但不在非恶性肿瘤组织中过表达)能有效用于检测血清中标记物,并且因此基本上具有临床用途且不必进行组织或器官活检。
根据图15,很明显血清中SPARC具有不同的分子量(此处以Western印迹图示),肿瘤SPARC的分子量低于血细胞产生的SPARC。因此,即使SPARC由肿瘤和非肿瘤的血细胞产生,肿瘤SPARC的存在也能够使用分子大小进行确定(如通过Western分析确定)或使用对肿瘤细胞产生的糖基化蛋白质特异的抗体来确定。
在其它研究中,我们检测了胃癌细胞系AGS上清液中的半胱氨酸蛋白酶抑制剂SN。图16描述了单独培养基或培养的AGS细胞上清液中的Western分析。图16中右侧泳道显示出对应半胱氨酸蛋白酶抑制剂SN蛋白质的致密条带。
因此,我们从图10推断本发明GTM适于诊断疾病进展早期、中期或晚期的胃癌。
尽管某些标记物蛋白质能被糖基化,但糖基化模式的变化在某些情况下能够导致对缺少常见糖基化模式的GTM形式的错误检测。因此,在本发明某些实施方案中,GTM免疫原包括去糖基化的GTM或去糖基化的GTM片段。可使用本技术领域中已知的一种或多种糖苷酶完成去糖基化。备选地,GTM eDNA能够在糖基化缺陷细胞系如包括大肠肝菌(E.coli)的原核细胞中表达,从而产生非糖基化的蛋白质或肽。还应该意识到糖基化的水平和质量对糖侧链必需前体的存在敏感。因此,在缺乏必需糖质的情况下,“正常”糖基化不会发生,但是可以发现更短的或缺失侧链的糖。此种“糖基化变体”可以用作免疫原,从便产生对不同类型标记物基因特异的抗体。
另外,某些GTM可以形成同源二聚体或异二聚体或其它类型多聚体形式。例如,抑制蛋白βA是47kDa的蛋白质,其能形成分子量97kDa的同源二聚体(激活蛋白A),并与45kDa的蛋白质抑制蛋白βB形成92kDa的异源二聚体(也称作激活蛋白AB)。因此,应该意识到Western分析或者提供分子量的其它类型分析不必仅限于检测GTM的单体形式。相反,人们能够容易地意识到可以检测任何形式的GTM而不管其分子量如何。因此,对GTM多聚体形式的检测可以容易地用于诊断胃癌的存在。此外,对于那些对胃肿瘤分期(1-4)或胃肿瘤类型(扩散型或肠型)有选择性的GTM,对其多聚体形式的检测能提供用于评价胃癌分期或类型的指标。
一旦产生抗GTM的抗体或抗血清,此种抗体制品能用于多种方法。首先,使用酶联免疫吸附测定(ELISA)或放射免疫测定(RIA)方法定量GTM的蛋白质或肽。使用免疫组织化学可以在组织样品中进行免疫检测。这些方法在本技术领域中全部已知,因此不必在本文进一步描述。
实施例7:包含GTM寡核苷酸的载体
本发明其它实施方案包括对于标记物基因或其部分(“标记物肽”)、或标记物基因产物片段的体外表达有用的载体。例如,可制备具有编码GTM的寡核苷酸的载体。许多此类载体基于本技术领域已知的标准载体。本发明还包括能用于转染多种细胞系以制备产GTM细胞系的载体,其中所述细胞能用来产生所需量的GTM从而开发用于GTM检测或GTM标准化改良测定法的特异性抗体或其它试剂。
应当理解:为了制备这样的载体,把包含完整可读框或编码待表达蛋白质部分的此可读框部分的寡核苷酸插入含有启动子区、一个或多个增强子区域的载体中,其中启动子区和增强子区可操作性地与具有起始密码子、可读框和终止密码子的寡核苷酸连接。产生表达载体的方法在本技术领域是已知的从而不必在本文重复。
还应该意识到:可以将一个或多个选择标记插入表达载体,以便允许选择出的含有目的表达载体的细胞系扩大培养。而且,还可以在框架中插入本技术领域已知的前导区,从而指引蛋白质或蛋白质片段的分泌、内部贮存或膜插入。
实施例8:用包含GTM的载体转染的细胞
在仍然进一步的实施方案中,提供的细胞能表达GTM、GTM片段或肽标记物。原核细胞和真核细胞都能如此使用。例如,大肠肝菌(一种原核细胞)能用来产生大量的缺乏成熟糖基化的GTM(如果特定GTM在正常情况下是糖基化的)。COS细胞、293细胞和多种其它真核细胞能用来产生糖基化的或者具有正确折叠(并因此具有天然形式GTM蛋白质三维结构)的GTM。转染此种细胞的方法在本技术领域中是已知的从而不必在本文中进一步描述。
实施例9:试剂盒
以本发明发现为基础,可生产几种类型的检测试剂盒。首先,试剂盒能制备成具有预先装载检测分子(或“捕获试剂”)的检测装置。在检测GTMmRNA的实施方案中,此种装置包括基质(如玻璃、硅、石英、金属等),在其上面是作为可与待检测的RNA杂交的捕获试剂的寡核苷酸。在一些实施方案中,通过mRNA(标记有cy3、cy5、放射性标记或其它标记)与基质上的寡核苷酸杂交完成对mRNA的直接检测。在其它实施方案中,通过先制备目的mRNA的互补DNA(cDNA)来实现对mRNA的检测。然后标记的cDNA与基质上的寡核苷酸杂交并检测。
无论采用的是何种检测方法,要对测试的GTM表达与标准的表达测定比较。例如,RNA表达要对总的细胞DNA,组成型表达RNA(例如,核糖体RNA)的表达或者其它相对恒定的标记物进行标准化。
抗体还可在试剂盒中用作捕获试剂。在一些实施方案中,基质(如多孔板)可以具有连接于其上的特异GTM捕获试剂。在一些实施方案中,试剂盒内附有封闭试剂。封闭试剂用于减少非特异性结合。例如,使用任何方便来源但不含有GTM寡核苷酸的过量DNA如鲑精DNA能减少非特异的寡核苷酸结合。使用过量封闭蛋白质如血清白蛋白能减少非特异性抗体结合。应该认识到检测寡核苷酸和蛋白质的许多方法在本技术领域中已知,并且在本发明范围内可以使用和考虑能够特异性检测GTM相关分子的任何策略。
在依靠抗体检测的实施方案中,GTM蛋白质或肽可以基于每个细胞来表示,或者基于总的细胞、组织或液体蛋白质、液体体积、组织质量(重量)来表示。此外,血清中GTM可以基于相对高丰度血清蛋白质如白蛋白来表示。
检测试剂盒除了包括基质外还包括捕获试剂(如探针),洗涤溶液(如SSC、其它盐类、缓冲液、去污剂等)以及检测部分(如cy3、cy5、放射性标记等)。试剂盒还包括使用说明书和包装物。
尽管本发明关于其中特定的实施方案进行了描述,但应该认识到可以在不脱离本发明的范围在内使用涉及使用本公开标记物的其它实施方案。
工业适用性
用于检测GTM家族成员的方法包括使用微阵列和/或实时PCR方法检测核苷酸以及检测蛋白质和肽。本发明的组合物和方法可用于诊断装置和试剂盒的制造、疾病的诊断、治疗效果的评价,并且也可用于生产适于在生物样品中测定GTM家族成员表达的试剂。
序列表
<110>环太平洋生物技术有限公司
查尔斯·戴维斯·小法默
<120>用于胃癌检测的标记物
<130>JX225559
<140>PCT/US2004/0122959
<141>2004-07-16
<150>US60/487,906
<151>2003-07-17
<160>108
<170>PatentIn版本3.3
<210>1
<211>26
<212>DNA
<213>人类
<400>1
aaatacaaaa ggacacattc aaagga 26
<210>2
<211>20
<212>DNA
<213>人类
<400>2
gccagtggaa ggatgttccc 20
<210>3
<211>19
<212>DNA
<213>人类
<400>3
agtcccagcc caacttgga 19
<210>4
<211>17
<212>DNA
<213>人类
<400>4
gtggcaatgc cgctgaa 17
<210>5
<211>18
<212>DNA
<213>人类
<400>5
caggtcagca agggcacc 18
<210>6
<211>24
<212>DNA
<213>人类
<400>6
acaacatgat atgtgctgga ctgg 24
<210>7
<211>24
<212>DNA
<213>人类
<400>7
cttgagtaca acgctgacct cttc 24
<210>8
<211>24
<212>DNA
<213>人类
<400>8
gattcttgtc catagtgcat ctgc 24
<210>9
<211>19
<212>DNA
<213>人类
<400>9
aggccagctt ctgcttgga 19
<210>10
<211>23
<212>DNA
<213>人类
<400>10
gcctctctgc tgatgacata cgt 23
<210>11
<211>21
<212>DNA
<213>人类
<400>11
ccagaccacc ttataccagc g 21
<210>12
<211>17
<212>DNA
<213>人类
<400>12
cgcagaacgc ctgcaaa 17
<210>13
<211>18
<212>DNA
<213>人类
<400>13
cgctagcagc gaccacct 18
<210>14
<211>23
<212>DNA
<213>人类
<400>14
tcttccctgt acactggcag ttc 23
<210>15
<211>19
<212>DNA
<213>人类
<400>15
tcgggaggcc cgttagtaa 19
<210>16
<211>23
<212>DNA
<213>人类
<400>16
tggaaggact acacggccta tag 23
<210>17
<211>20
<212>DNA
<213>人类
<400>17
gacggttcct cgcagttcaa 20
<210>18
<211>16
<212>DNA
<213>人类
<400>18
ctgcccaccc cttcca 16
<210>19
<211>21
<212>DNA
<213>人类
<400>19
tccacgcatt ttccaggata a 21
<210>20
<211>22
<212>DNA
<213>人类
<400>20
ggtccatgtc atcaccaatg tt 22
<210>21
<211>21
<212>DNA
<213>人类
<400>21
aaaaatcttt gccggaaatg c 21
<210>22
<211>20
<212>DNA
<213>人类
<400>22
ttgatggcat cgctcagatc 20
<210>23
<211>23
<212>DNA
<213>人类
<400>23
tgcttctgca attctgatat gga 23
<210>24
<211>23
<212>DNA
<213>人类
<400>24
tcttggcatt ttctacaaca ggg 23
<210>25
<211>24
<212>DNA
<213>人类
<400>25
gggaacttcg tagatctgga aaga 24
<210>26
<211>25
<212>DNA
<213>人类
<400>26
tgacagcaac aactcagtag gaaaa 25
<210>27
<211>22
<212>DNA
<213>人类
<400>27
tcacagctca agtacacctg gg 22
<210>28
<211>20
<212>DNA
<213>人类
<400>28
gagaggatgc cttggagggt 20
<210>29
<211>23
<212>DNA
<213>人类
<400>29
ccgtgacaca gttctgctta cag 23
<210>30
<211>21
<212>DNA
<213>人类
<400>30
ccaatcaatg ccaggaagag a 21
<210>31
<211>17
<212>DNA
<213>人类
<400>31
ccctgatcgc cgagttg 17
<210>32
<211>25
<212>DNA
<213>人类
<400>32
agtgacagca tcaaaactca aattg 25
<210>33
<211>20
<212>DNA
<213>人类
<400>33
ggacctgtgg aagtatccgc 20
<210>34
<211>25
<212>DNA
<213>人类
<400>34
acaggacatc atacatggtt tcaaa 25
<210>35
<211>23
<212>DNA
<213>人类
<400>35
ttttgcaggc ttcacatacc ttt 23
<210>36
<211>18
<212>DNA
<213>人类
<400>36
gaaaaagcgg gtggtgca 18
<210>37
<211>23
<212>DNA
<213>人类
<400>37
aaggagattc cagctgtcac ttc 23
<210>38
<211>28
<212>DNA
<213>人类
<400>38
taggtttggt catagatagg tcctgagt 28
<210>39
<211>22
<212>DNA
<213>人类
<400>39
tgtaaaccgc tccacttcac at 22
<210>40
<211>25
<212>DNA
<213>人类
<400>40
ttctgtcctt cctagtccct ttagg 25
<210>41
<211>21
<212>DNA
<213>人类
<400>41
aagccgaatt tgctagttgc a 21
<210>42
<211>22
<212>DNA
<213>人类
<400>42
tctgcaagtt catcccctct tt 22
<210>43
<211>21
<212>DNA
<213>人类
<400>43
agtcctggcc gttgaaatac c 21
<210>44
<211>19
<212>DNA
<213>人类
<400>44
tgtcacgtgg cgtcacagt 19
<210>45
<211>34
<212>DNA
<213>人类
<400>45
ttggaaatga gtgcaaaccc tcttgataat aatg 34
<210>46
<211>23
<212>DNA
<213>人类
<400>46
aggaacagtt gcttgcggcc agc 23
<210>47
<211>29
<212>DNA
<213>人类
<400>47
agccagaact gcagaagaaa cagttgtgc 29
<210>48
<211>29
<212>DNA
<213>人类
<400>48
ttcactggag gtcaattgca cagcagaat 29
<210>49
<211>26
<212>DNA
<213>人类
<400>49
agcaaggtcc ttccatagtg acgccc 26
<210>50
<211>25
<212>DNA
<213>人类
<400>50
cttgccagag tgactctgga ggccc 25
<210>51
<211>30
<212>DNA
<213>人类
<400>51
ccatcacaga tcattacatc caggtcctca 30
<210>52
<211>36
<212>DNA
<213>人类
<400>52
taaggattca aaccatttgc caaaaatgag tctaag 36
<210>53
<211>33
<212>DNA
<213>人类
<400>53
cgtaattctt ctggatgtct ccttcacatt ctg 33
<210>54
<211>30
<212>DNA
<213>人类
<400>54
tcagtccctg tatggagacc caaaagagaa 30
<210>55
<211>33
<212>DNA
<213>人类
<400>55
caagatgacc aagatgtata aagggttcca agc 33
<210>56
<211>28
<212>DNA
<213>人类
<400>56
tgtctgaacc gcaccagcca agagaata 28
<210>57
<211>22
<212>DNA
<213>人类
<400>57
ctgccagcca ccgaggaagc tc 22
<210>58
<211>22
<212>DNA
<213>人类
<400>58
tggaccagca ccccattgac gg 22
<210>59
<211>31
<212>DNA
<213>人类
<400>59
agtgttaatt ccaatcactt caccgtccag g 31
<210>60
<211>27
<212>DNA
<213>人类
<400>60
aggcccaaga ccggctacat cagagtc 27
<210>61
<211>25
<212>DNA
<213>人类
<400>61
tctggcagat tccgatgccc cacaa 25
<210>62
<211>20
<212>DNA
<213>人类
<400>62
ccaggccagg agcagctcgg 20
<210>63
<211>21
<212>DNA
<213>人类
<400>63
tgactccagg cccgcaatgg a 21
<210>64
<211>25
<212>DNA
<213>人类
<400>64
cagcctccag ccaacagacc tcagg 25
<210>65
<211>29
<212>DNA
<213>人类
<400>65
acagaatgta gggatgggtt aagcctgca 29
<210>66
<211>23
<212>DNA
<213>人类
<400>66
ttcaaggacc ggttcatttg gcg 23
<210>67
<211>1778
<212>DNA
<213>人类
<400>67
tagaagttta caatgaagtt tcttctaata ctgctcctgc aggccactgc ttctggagct 60
cttcccctga acagctctac aagcctggaa aaaaataatg tgctatttgg tgagagatac 120
ttagaaaaat tttatggcct tgagataaac aaacttccag tgacaaaaat gaaatatagt 180
ggaaacttaa tgaaggaaaa aatccaagaa atgcagcact tcttgggtct gaaagtgacc 240
gggcaactgg acacatctac cctggagatg atgcacgcac ctcgatgtgg agtccccgat 300
ctccatcatt tcagggaaat gccagggggg cccgtatgga ggaaacatta tatcacctac 360
agaatcaata attacacacc tgacatgaac cgtgaggatg ttgactacgc aatccggaaa 420
gctttccaag tatggagtaa tgttaccccc ttgaaattca gcaagattaa cacaggcatg 480
gctgacattt tggtggtttt tgcccgtgga gctcatggag acttccatgc ttttgatggc 540
aaaggtggaa tcctagccca tgcttttgga cctggatctg gcattggagg ggatgcacat 600
ttcgatgagg acgaattctg gactacacat tcaggaggca caaacttgtt cctcactgct 660
gttcacgaga ttggccattc cttaggtctt ggccattcta gtgatccaaa ggctgtaatg 720
ttccccacct acaaatatgt cgacatcaac acatttcgcc tctctgctga tgacatacgt 780
ggcattcagt ccctgtatgg agacccaaaa gagaaccaac gcttgccaaa tcctgacaat 840
tcagaaccag ctctctgtga ccccaatttg agttttgatg ctgtcactac cgtgggaaat 900
aagatctttt tcttcaaaga caggttcttc tggctgaagg tttctgagag accaaagacc 960
agtgttaatt taatttcttc cttatggcca accttgccat ctggcattga agctgcttat 1020
gaaattgaag ccagaaatca agtttttctt tttaaagatg acaaatactg gttaattagc 1080
aatttaagac cagagccaaa ttatcccaag agcatacatt cttttggttt tcctaacttt 1140
gtgaaaaaaa ttgatgcagc tgtttttaac ccacgttttt ataggaccta cttctttgta 1200
gataaccagt attggaggta tgatgaaagg agacagatga tggaccctgg ttatcccaaa 1260
ctgattacca agaacttcca aggaatcggg cctaaaattg atgcagtctt ctattctaaa 1320
aacaaatact actatttctt ccaaggatct aaccaatttg aatatgactt cctactccaa 1380
cgtatcacca aaacactgaa aagcaatagc tggtttggtt gttagaaatg gtgtaattaa 1440
tggtttttgt tagttcactt cagcttaata agtatttatt gcatatttgc tatgtcctca 1500
gtgtaccact acttagagat atgtatcata aaaataaaat ctgtaaacca taggtaatga 1560
ttatataaaa tacataatat ttttcaattt tgaaaactct aattgtccat tcttgcttga 1620
ctctactatt aagtttgaaa atagttacct tcaaagcaag ataattctat ttgaagcatg 1680
ctctgtaagt tgcttcctaa catccttgga ctgagaaatt atacttactt ctggcataac 1740
taaaattaag tatatatatt ttggctcaaa taaaattg 1778
<210>68
<211>1840
<212>DNA
<213>人类
<400>68
tccacacaca caaaaaacct gcgcgtgagg ggggaggaaa agcagggcct ttaaaaaggc 60
aatcacaaca acttttgctg ccaggatgcc cttgctttgg ctgagaggat ttctgttggc 120
aagttgctgg attatagtga ggagttcccc caccccagga tccgaggggc acagcgcggc 180
ccccgactgt ccgtcctgtg cgctggccgc cctcccaaag gatgtaccca actctcagcc 240
agagatggtg gaggccgtca agaagcacat tttaaacatg ctgcacttga agaagagacc 300
cgatgtcacc cagccggtac ccaaggcggc gcttctgaac gcgatcagaa agcttcatgt 360
gggcaaagtc ggggagaacg ggtatgtgga gatagaggat gacattggaa ggagggcaga 420
aatgaatgaa cttatggagc agacctcgga gatcatcacg tttgccgagt caggaacagc 480
caggaagacg ctgcacttcg agatttccaa ggaaggcagt gacctgtcag tggtggagcg 540
tgcagaagtc tggctcttcc taaaagtccc caaggccaac aggaccagga ccaaagtcac 600
catccgcctc ttccagcagc agaagcaccc gcagggcagc ttggacacag gggaagaggc 660
cgaggaagtg ggcttaaagg gggagaggag tgaactgttg ctctctgaaa aagtagtaga 720
cgctcggaag agcacctggc atgtcttccc tgtctccagc agcatccagc ggttgctgga 780
ccagggcaag agctccctgg acgttcggat tgcctgtgag cagtgccagg agagtggcgc 840
cagcttggtt ctcctgggca agaagaagaa gaaagaagag gagggggaag ggaaaaagaa 900
gggcggaggt gaaggtgggg caggagcaga tgaggaaaag gagcagtcgc acagaccttt 960
cctcatgctg caggcccggc agtctgaaga ccaccctcat cgccggcgtc ggcggggctt 1020
ggagtgtgat ggcaaggtca acatctgctg taagaaacag ttctttgtca gtttcaagga 1080
catcggctgg aatgactgga tcattgctcc ctctggctat catgccaact actgcgaggg 1140
tgagtgcccg agccatatag caggcacgtc cgggtcctca ctgtccttcc actcaacagt 1200
catcaaccac taccgcatgc ggggccatag cccctttgcc aacctcaaat cgtgctgtgt 1260
gcccaccaag ctgagaccca tgtccatgtt gtactatgat gatggtcaaa acatcatcaa 1320
aaaggacatt cagaacatga tcgtggagga gtgtgggtgc tcatagagtt gcccagccca 1380
gggggaaagg gagcaagagt tgtccagaga agacagtggc aaaatgaaga aatttttaag 1440
gtttctgagt taaccagaaa aatagaaatt aaaaacaaaa caaaacaaaa aaaaaaacaa 1500
aaaaaaacaa aagtaaatta aaaacaaacc tgatgaaaca gatgaaacag atgaaggaag 1560
atgtggaaat cttagcctgc cttagccagg gctcagagat gaagcagtga agagacagat 1620
tgggagggaa agggagaatg gtgtaccctt tatttcttct gaaatcacac tgatgacatc 1680
agttgtttaa acggggtatt gtcctttccc cccttgaggt tcccttgtga gcttgaatca 1740
accaatctga tctgcagtag tgtggactag aacaacccaa atagcatcta gaaagccatg 1800
agtttgaaag ggcccatcac aggcactttc ctagcctaat 1840
<210>69
<211>1124
<212>DNA
<213>人类
<400>69
gccgctgcca ccgcaccccg ccatggagcg gccgtcgctg cgcgccctgc tcctcggcgc 60
cgctgggctg ctgctcctgc tcctgcccct ctcctcttcc tcctcttcgg acacctgcgg 120
cccctgcgag ccggcctcct gcccgcccct gcccccgctg ggctgcctgc tgggcgagac 180
ccgcgacgcg tgcggctgct gccctatgtg cgcccgcggc gagggcgagc cgtgcggggg 240
tggcggcgcc ggcagggggt actgcgcgcc gggcatggag tgcgtgaaga gccgcaagag 300
gcggaagggt aaagccgggg cagcagccgg cggtccgggt gtaagcggcg tgtgcgtgtg 360
caagagccgc tacccggtgt gcggcagcga cggcaccacc tacccgagcg gctgccagct 420
gcgcgccgcc agccagaggg ccgagagccg cggggagaag gccatcaccc aggtcagcaa 480
gggcacctgc gagcaaggtc cttccatagt gacgcccccc aaggacatct ggaatgtcac 540
tggtgcccag gtgtacttga gctgtgaggt catcggaatc ccgacacctg tcctcatctg 600
gaacaaggta aaaaggggtc actatggagt tcaaaggaca gaactcctgc ctggtgaccg 660
ggacaacctg gccattcaga cccggggtgg cccagaaaag catgaagtaa ctggctgggt 720
gctggtatct cctctaagta aggaagatgc tggagaatat gagtgccatg catccaattc 780
ccaaggacag gcttcagcat cagcaaaaat tacagtggtt gatgccttac atgaaatacc 840
agtgaaaaaa ggtgaaggtg ccgagctata aacctccaga atattattag tctgcatggt 900
taaaagtagt catggataac tacattacct gttcttgcct aataagtttc ttttaatcca 960
atccactaac actttagtta tattcactgg ttttacacag agaaatacaa aataaagatc 1020
acacatcaag actatctaca aaaatttatt atatatttac agaagaaaag catgcatatc 1080
attaaacaaa taaaatactt tttatcacaa aaaaaaaaaa aaaa 1124
<210>70
<211>1280
<212>DNA
<213>人类
<400>70
tgccgcagcc cccgcccgcc cgcagagctt ttgaaaggcg gcgggaggcg gcgagcgcca 60
tggccagtcc gggctgcctg ctgtgcgtgc tgggcctgct actctgcggg gcggcgagcc 120
tcgagctgtc tagaccccac ggcgacaccg ccaagaagcc catcatcgga atattaatgc 180
aaaaatgccg taataaagtc atgaaaaact atggaagata ctatattgct gcgtcctatg 240
taaagtactt ggagtctgca ggtgcgagag ttgtaccagt aaggctggat cttacagaga 300
aagactatga aatacttttc aaatctatta atggaatcct tttccctgga ggaagtgttg 360
acctcagacg ctcagattat gctaaagtgg ccaaaatatt ttataacttg tccatacaga 420
gttttgatga tggagactat tttcctgtgt ggggcacatg ccttggattt gaagagcttt 480
cactgctgat tagtggagag tgcttattaa ctgccacaga tactgttgac gtggcaatgc 540
cgctgaactt cactggaggt caattgcaca gcagaatgtt ccagaatttt cctactgagt 600
tgttgctgtc attagcagta gaacctctga ctgccaattt ccataagtgg agcctctccg 660
tgaagaattt tacaatgaat gaaaagttaa agaagttttt caatgtctta actacaaata 720
cagatggcaa gattgagttt atttcaacaa tggaaggata taagtatcca gtatatggtg 780
tccagtggca tccagagaaa gcaccttatg agtggaagaa tttggatggc atttcccatg 840
cacctaatgc tgtgaaaacc gcattttatt tagcagagtt ttttgttaat gaagctcgga 900
aaaacaacca tcattttaaa tctgaatctg aagaggagaa agcattgatt tatcagttca 960
gtccaattta tactggaaat atttcttcat ttcagcaatg ttacatattt gattgaaagt 1020
cttcaatttg ttaacagagc aaatttgaat aattccatga ttaaactgtt agaataactt 1080
gctactcatg gcaagattag gaagtcacag attcttttct ataatgtgcc tggctctgat 1140
tcttcattat gtatgtgact atttatataa cattagataa ttaaatagtg agacataaat 1200
agagtgcttt ttcatggaaa agccttctta tatctgaaga ttgaaaaata aatttactga 1260
aatacaaaaa aaaaaaaaaa 1280
<210>71
<211>2993
<212>DNA
<213>人类
<400>71
ggtggcgggt ggctggcggt tccgttaggt ctgagggagc gatggcggta cgcgcgttga 60
agctgctgac cacactgctg gctgtcgtgg ccgctgcctc ccaagccgag gtcgagtccg 120
aggcaggatg gggcatggtg acgcctgatc tgctcttcgc cgaggggacc gcagcctacg 180
cgcgcgggga ctggcccggg gtggtcctga gcatggaacg ggcgctgcgc tcccgggcag 240
ccctccgcgc ccttcgcctg cgctgccgca cccagtgtgc cgccgacttc ccgtgggagc 300
tggaccccga ctggtccccc agcccggccc aggcctcggg cgccgccgcc ctgcgcgacc 360
tgagcttctt cgggggcctt ctgcgtcgcg ctgcctgcct gcgccgctgc ctcgggccgc 420
cggccgccca ctcgctcagc gaagagatgg agctggagtt ccgcaagcgg agcccctaca 480
actacctgca ggtcgcctac ttcaagatca acaagttgga gaaagctgtt gctgcagcac 540
acaccttctt cgtgggcaat cctgagcaca tggaaatgca gcagaaccta gactattacc 600
aaaccatgtc tggagtgaag gaggccgact tcaaggatct tgagactcaa ccccatatgc 660
aagaatttcg actgggagtg cgactctact cagaggaaca gccacaggaa gctgtgcccc 720
acctagaggc ggcgctgcaa gaatactttg tggcctatga ggagtgccgt gccctctgcg 780
aagggcccta tgactacgat ggctacaact accttgagta caacgctgac ctcttccagg 840
ccatcacaga tcattacatc caggtcctca actgtaagca gaactgtgtc acggagcttg 900
cttcccaccc aagtcgagag aagccctttg aagacttcct cccatcgcat tataattatc 960
tgcagtttgc ctactataac attgggaatt atacacaggc tgttgaatgt gccaagacct 1020
atcttctctt cttccccaat gacgaggtga tgaaccaaaa tttggcctat tatgcagcta 1080
tgcttggaga agaacacacc agatccatcg gcccccgtga gagtgccaag gagtaccgac 1140
agcgaagcct actggaaaaa gaactgcttt tcttcgctta tgatgttttt ggaattccct 1200
ttgtggatcc ggattcatgg actccaggag aagtgattcc caagagattg caagagaaac 1260
agaagtcaga acgggaaaca gccgtacgca tctcccagga gattgggaac cttatgaagg 1320
aaatcgagac ccttgtggaa gagaagacca aggagtcact ggatgtgagc agactgaccc 1380
gggaaggtgg ccccctgctg tatgaaggca tcagtctcac catgaactcc aaactcctga 1440
atggttccca gcgggtggtg atggacggcg taatctctga ccacgagtgt caggagctgc 1500
agagactgac caatgtggca gcaacctcag gagatggcta ccggggtcag acctccccac 1560
atactcccaa tgaaaagttc tatggtgtca ctgtcttcaa agccctcaag ctggggcaag 1620
aaggcaaagt tcctctgcag agtgcccacc tgtactacaa cgtgacggag aaggtgcggc 1680
gcatcatgga gtcctacttc cgcctggata cgcccctcta cttttcctac tctcatctgg 1740
tgtgccgcac tgccatcgaa gaggtccagg cagagaggaa ggatgatagt catccagtcc 1800
acgtggacaa ctgcatcctg aatgccgaga ccctcgtgtg tgtcaaagag cccccagcct 1860
acaccttccg cgactacagc gccatccttt acctaaatgg ggacttcgat ggcggaaact 1920
tttatttcac tgaactggat gccaagaccg tgacggcaga ggtgcagcct cagtgtggaa 1980
gagccgtggg attctcttca ggcactgaaa acccacatgg agtgaaggct gtcaccaggg 2040
ggcagcgctg tgccatcgcc ctgtggttca ccctggaccc tcgacacagc gagcgggtga 2100
gagcagctcg agcgggtgag agcagctggt gctgtggtga cccgttccca gagcgccctt 2160
ggtttgcctt tctcttcccc aaatcccatt gccagtggct gagacacgaa aggagcactt 2220
gggacaccag ctccaacgcc ctgtcattat ggtcacattg ccttgtcctc cctgggcctg 2280
ctgtgaacgg gatccaggtg gggaaagagg tcaagacagg gagcgatgct gagttcttgg 2340
ttccctcctt gggccccact tcagctgtcc ttttccagag agtaggacct gctgggaagg 2400
agatgagcct ggggccatta aggaaccttc cttgtcccct gggaagtagc agctgagaga 2460
tagcgagtgt ctggagcgga ggcctctctg aatgggcagg ggtttgtcct tgcaggacag 2520
ggtgcaggca gatgacctgg tgaagatgct cttcagccca gaagagatgg tcctctccca 2580
ggagcagccc ctggatgccc agcagggccc ccccgaacct gcacaagagt ctctctcagg 2640
cagtgaatcg aagcccaagg atgagctatg acagcgtcca ggtcagacgg atgggtgact 2700
agacccatgg agaggaactc ttctgcactc tgagctggcc agcccctcgg ggctgcagag 2760
cagtgagcct acatctgcca ctcagccgag gggaccctgc tcacagcctt ctacatggtg 2820
ctactgctct tggagtggac atgaccagac accgcacccc ctggatctgg ctgagggctc 2880
aggacacagg cccagccacc cccaggggcc tccacaggcc gctgcataac agcgatacag 2940
tacttaagtg tctgtgtaga caaccaaaga ataaatgatt catggttttt ttt 2993
<210>72
<211>736
<212>DNA
<213>人类
<400>72
ggctctcacc ctcctctcct gcagctccag ctttgtgctc tgcctctgag gagaccatgg 60
cccggcctct gtgtaccctg ctactcctga tggctaccct ggctggggct ctggcctcga 120
gctccaagga ggagaatagg ataatcccag gtggcatcta tgatgcagac ctcaatgatg 180
agtgggtaca gcgtgccctt cacttcgcca tcagcgagta caacaaggcc accgaagatg 240
agtactacag acgcccgctg caggtgctgc gagccaggga gcagaccttt gggggggtga 300
attacttctt cgacgtagag gtgggccgca ccatatgtac caagtcccag cccaacttgg 360
acacctgtgc cttccatgaa cagccagaac tgcagaagaa acagttgtgc tctttcgaga 420
tctacgaagt tccctgggag gacagaatgt ccctggtgaa ttccaggtgt caagaagcct 480
aggggtctgt gccaggccag tcacaccgac caccacccac tcccacccac tgtagtgctc 540
ccacccctgg actggtggcc cccaccctgc gggaggcctc cccatgtgcc tgtgccaaga 600
gacagacaga gaaggctgca ggagtccttt gttgctcagc agggcgctct gccctccctc 660
cttccttctt gcttctaata gacctggtac atggtacaca cacccccacc tcctgcaatt 720
aaacagtagc atcgcc 736
<210>73
<211>2820
<212>DNA
<213>人类
<400>73
ggcgggttcg cgccccgaag gctgagagct ggcgctgctc gtgccctgtg tgccagacgg 60
cggagctccg cggccggacc ccgcggcccc gctttgctgc cgactggagt ttgggggaag 120
aaactctcct gcgccccaga agatttcttc ctcggcgaag ggacagcgaa agatgagggt 180
ggcaggaaga gaaggcgctt tctgtctgcc ggggtcgcag cgcgagaggg cagtgccatg 240
ttcctctcca tcctagtggc gctgtgcctg tggctgcacc tggcgctggg cgtgcgcggc 300
gcgccctgcg aggcggtgcg catccctatg tgccggcaca tgccctggaa catcacgcgg 360
atgcccaacc acctgcacca cagcacgcag gagaacgcca tcctggccat cgagcagtac 420
gaggagctgg tggacgtgaa ctgcagcgcc gtgctgcgct tcttcttctg tgccatgtac 480
gcgcccattt gcaccctgga gttcctgcac gaccctatca agccgtgcaa gtcggtgtgc 540
caacgcgcgc gcgacgactg cgagcccctc atgaagatgt acaaccacag ctggcccgaa 600
agcctggcct gcgacgagct gcctgtctat gaccgtggcg tgtgcatttc gcctgaagcc 660
atcgtcacgg acctcccgga ggatgttaag tggatagaca tcacaccaga catgatggta 720
caggaaaggc ctcttgatgt tgactgtaaa cgcctaagcc ccgatcggtg caagtgtaaa 780
aaggtgaagc caactttggc aacgtatctc agcaaaaact acagctatgt tattcatgcc 840
aaaataaaag ctgtgcagag gagtggctgc aatgaggtca caacggtggt ggatgtaaaa 900
gagatcttca agtcctcatc acccatccct cgaactcaag tcccgctcat tacaaattct 960
tcttgccagt gtccacacat cctgccccat caagatgttc tcatcatgtg ttacgagtgg 1020
cgttcaagga tgatgcttct tgaaaattgc ttagttgaaa aatggagaga tcagcttagt 1080
aaaagatcca tacagtggga agagaggctg caggaacagc ggagaacagt tcaggacaag 1140
aagaaaacag ccgggcgcac cagtcgtagt aatcccccca aaccaaaggg aaagcctcct 1200
gctcccaaac cagccagtcc caagaagaac attaaaacta ggagtgccca gaagagaaca 1260
aacccgaaaa gagtgtgagc taactagttt ccaaagcgga gacttccgac ttccttacag 1320
gatgaggctg ggcattgcct gggacagcct atgtaaggcc atgtgcccct tgccctaaca 1380
actcactgca gtgctcttca tagacacatc ttgcagcatt tttcttaagg ctatgcttca 1440
gtttttcttt gtaagccatc acaagccata gtggtaggtt tgccctttgg tacagaaggt 1500
gagttaaagc tggtggaaaa ggcttattgc attgcattca gagtaacctg tgtgcatact 1560
ctagaagagt agggaaaata atgcttgtta caattcgacc taatatgtgc attgtaaaat 1620
aaatgccata tttcaaacaa aacacgtaat ttttttacag tatgttttat taccttttga 1680
tatctgttgt tgcaatgtta gtgatgtttt aaaatgtgat gaaaatataa tgtttttaag 1740
aaggaacagt agtggaatga atgttaaaag atctttatgt gtttatggtc tgcagaagga 1800
tttttgtgat gaaaggggat tttttgaaaa attagagaag tagcatatgg aaaattataa 1860
tgtgtttttt taccaatgac ttcagtttct gtttttagct agaaacttaa aaacaaaaat 1920
aataataaag aaaaataaat aaaaaggaga ggcagacaat gtctggattc ctgttttttg 1980
gttacctgat ttccatgatc atgatgcttc ttgtcaacac cctcttaagc agcaccagaa 2040
acagtgagtt tgtctgtacc attaggagtt aggtactaat tagttggcta atgctcaagt 2100
attttatacc cacaagagag gtatgtcact catcttactt cccaggacat ccaccctgag 2160
aataatttga caagcttaaa aatggccttc atgtgagtgc caaattttgt ttttcttcat 2220
ttaaatattt tctttgccta aatacatgtg agaggagtta aatataaatg tacagagagg 2280
aaagttgagt tccacctctg aaatgagaat tacttgacag ttgggatact ttaatcagaa 2340
aaaaagaact tatttgcagc attttatcaa caaatttcat aattgtggac aattggaggc 2400
atttatttta aaaaacaatt ttattggcct tttgctaaca cagtaagcat gtattttata 2460
aggcattcaa taaatgcaca acgcccaaag gaaataaaat cctatctaat cctactctcc 2520
actacacaga ggtaatcact attagtattt tggcatatta ttctccaggt gtttgcttat 2580
gcacttataa aatgatttga acaaataaaa ctaggaacct gtatacatgt gtttcataac 2640
ctgcctcctt tgcttggccc tttattgaga taagttttcc tgtcaagaaa gcagaaacca 2700
tctcatttct aacagctgtg ttatattcca tagtatgcat tactcaacaa actgttgtgc 2760
tattggatac ttaggtggtt tcttcactga caatactgaa taaacatctc accggaattc 2820
<210>74
<211>2480
<212>DNA
<213>人类
<400>74
agtactaaca tggactaatc tgtgggagca gtttattcca gtatcaccca gggtgcagcc 60
acaccaggac tgtgttgaag ggtgtttttt ttcttttaaa tgtaatacct cctcatcttt 120
tcttcttaca cagtgtctga gaacatttac attatagata agtagtacat ggtggataac 180
ttctactttt aggaggacta ctctcttctg acagtcctag actggtcttc tacactaaga 240
caccatgaag gagtatgtgc tcctattatt cctggctttg tgctctgcca aacccttctt 300
tagcccttca cacatcgcac tgaagaatat gatgctgaag gatatggaag acacagatga 360
tgatgatgat gatgatgatg atgatgatga tgatgatgag gacaactctc tttttccaac 420
aagagagcca agaagccatt tttttccatt tgatctgttt ccaatgtgtc catttggatg 480
tcagtgctat tcacgagttg tacattgctc agatttaggt ttgacctcag tcccaaccaa 540
cattccattt gatactcgaa tgcttgatct tcaaaacaat aaaattaagg aaatcaaaga 600
aaatgatttt aaaggactca cttcacttta tggtctgatc ctgaacaaca acaagctaac 660
gaagattcac ccaaaagcct ttctaaccac aaagaagttg cgaaggctgt atctgtccca 720
caatcaacta agtgaaatac cacttaatct tcccaaatca ttagcagaac tcagaattca 780
tgaaaataaa gttaagaaaa tacaaaagga cacattcaaa ggaatgaatg ctttacacgt 840
tttggaaatg agtgcaaacc ctcttgataa taatgggata gagccagggg catttgaagg 900
ggtgacggtg ttccatatca gaattgcaga agcaaaactg acctcagttc ctaaaggctt 960
accaccaact ttattggagc ttcacttaga ttataataaa atttcaacag tggaacttga 1020
ggattttaaa cgatacaaag aactacaaag gctgggccta ggaaacaaca aaatcacaga 1080
tatcgaaaat gggagtcttg ctaacatacc acgtgtgaga gaaatacatt tggaaaacaa 1140
taaactaaaa aaaatccctt caggattacc agagttgaaa tacctccaga taatcttcct 1200
tcattctaat tcaattgcaa gagtgggagt aaatgacttc tgtccaacag tgccaaagat 1260
gaagaaatct ttatacagtg caataagttt attcaacaac ccggtgaaat actgggaaat 1320
gcaacctgca acatttcgtt gtgttttgag cagaatgagt gttcagcttg ggaactttgg 1380
aatgtaataa ttagtaattg gtaatgtcca tttaatataa gattcaaaaa tccctacatt 1440
tggaatactt gaactctatt aataatggta gtattatata tacaagcaaa tatctattct 1500
caagtggtaa gtccactgac ttattttatg acaagaaatt tcaacggaat tttgccaaac 1560
tattgataca taagggttga gagaaacaag catctattgc agtttctttt tgcgtacaaa 1620
tgatcttaca taaatctcat gcttgaccat tcctttcttc ataacaaaaa agtaagatat 1680
tcggtattta acactttgtt atcaagcata ttttaaaaag aactgtactg taaatggaat 1740
gcttgactta gcaaaatttg tgctctttca tttgctgtta gaaaaacaga attaacaaag 1800
acagtaatgt gaagagtgca ttacactatt cttattcttt agtaacttgg gtagtactgt 1860
aatattttta atcatcttaa agtatgattt gatataatct tattgaaatt accttatcat 1920
gtcttagagc ccgtctttat gtttaaaact aatttcttaa aataaagcct tcagtaaatg 1980
ttcattacca acttgataaa tgctactcat aagagctggt ttggggctat agcatatgct 2040
tttttttttt taattattac ctgatttaaa aatctctgta aaaacgtgta gtgtttcata 2100
aaatctgtaa ctcgcatttt aatgatccgc tattataagc ttttaatagc atgaaaattg 2160
ttaggctata taacattgcc acttcaactc taaggaatat ttttgagata tccctttgga 2220
agaccttgct tggaagagcc tggacactaa caattctaca ccaaattgtc tcttcaaata 2280
cgtatggact ggataactct gagaaacaca tctagtataa ctgaataagc agagcatcaa 2340
attaaacaga cagaaaccga aagctctata taaatgctca gagttcttta tgtatttctt 2400
attggcattc aacatatgta aaatcagaaa acagggaaat tttcattaaa aatattggtt 2460
tgaaataaaa aaaaaaaaaa 2480
<210>75
<211>1887
<212>DNA
<213>人类
<400>75
cgcgcagccc ctccggccgc gggcgcagcg ggggcgctgg tggagctgcg aagggccagg 60
tccggcgggc ggggcggcgg ctggcactgg ctccggactc tgcccggcca gggcggcggc 120
tccagccggg agggcgacgt ggagcggcca cgtggagcgg cccgggggag gctggcggcg 180
ggaggcgagg cgcgggcggc gcagcagcca ggagcgccca cggagctgga cccccagagc 240
cgcgcggcgc cgcagcagtt ccaggaagga tgttaccttt gacgatgaca gtgttaatcc 300
tgctgctgct ccccacgggt caggctgccc caaaggatgg agtcacaagg ccagactctg 360
aagtgcagca tcagctcctg cccaacccct tccagccagg ccaggagcag ctcggacttc 420
tgcagagcta cctaaaggga ctaggaagga cagaagtgca actggagcat ctgagccggg 480
agcaggttct cctctacctc tttgccctcc atgactatga ccagagtgga cagctggatg 540
gcctggagct gctgtccatg ttgacagctg ctctggcccc tggagctgcc aactctccta 600
ccaccaaccc ggtgatattg atagtggaca aagtgctcga gacgcaggac ctgaatgggg 660
atgggctcat gacccctgct gagctcatca acttcccggg agtagccctc aggcacgtgg 720
agcccggaga gccccttgct ccatctcctc aggagccaca agctgttgga aggcagtccc 780
tattagctaa aagcccatta agacaagaaa cacaggaagc ccctggtccc agagaagaag 840
caaagggcca ggtagaggcc agaagggagt ctttggatcc tgtccaggag cctgggggcc 900
aggcagaggc tgatggagat gttccagggc ccagagggga agctgagggc caggcagagg 960
ctaaaggaga tgcccctggg cccagagggg aagctggggg ccaggcagag gctgaaggag 1020
atgcccccgg gcccagaggg gaagctgggg gccaggcaga ggccagggag aatggagagg 1080
aggccaagga acttccaggg gaaacactgg agtctaagaa cacccaaaat gactttgagg 1140
tgcacattgt tcaagtggag aatgatgaga tctagatctt gaagatacag gtaccccacg 1200
aagtctcagt gccagaacat aagccctgaa gtgggcaggg gaaatgtacg ctgggacaag 1260
gaccatctct gtgccccctg tctggtccca gtaggtatca ggtctttctg tgcagctcag 1320
ggagacccta agttaagggg cagattacca ataaagaact gaatgaattc atccccccgg 1380
gccacctctc tacccgtcca gcctgcccag accctctcag aggaacgggg ttggggaccg 1440
aaaggacagg gatgccgcct gcccagtgtt tctgggcctc acggtgctcc ggcagcagag 1500
cgcatggtgc tagccatggc cggctgcaga ggacccagtg aggaaagctc agtctatccc 1560
tgggccccaa accctcaccg gttccccctc acctggtgtt cagacacccc atgctctcct 1620
gcagctcagg gcaggtgacc ccatccccag taatattaat catcactaga actttttgag 1680
agccttgtac acatcaggca tcatgctggg cattttatat atgattttat cctcacaata 1740
attctgtagc caagcagaat tggttccatt tgacagatga agaaattgag gcagattgcg 1800
ttaagtgctg taccctaagg tgatatgcag ctaattaaat ggcagatttg aaaaaaaaaa 1860
aaaaaaaaaa aaaaaaaaaa aaaaaaa 1887
<210>76
<211>1580
<212>DNA
<213>人类
<400>76
catcctgcca cccctagcct tgctggggac gtgaaccctc tccccgcgcc tgggaagcct 60
tcttggcacc gggacccgga gaatccccac ggaagccagt tccaaaaggg atgaaaaggg 120
ggcgtttcgg gcactgggag aagcctgtat tccagggccc ctcccagagc aggaatctgg 180
gacccaggag tgccagcctc acccacgcag atcctggcca tgagagctcc gcacctccac 240
ctctccgccg cctctggcgc ccgggctctg gcgaagctgc tgccgctgct gatggcgcaa 300
ctctgggccg cagaggcggc gctgctcccc caaaacgaca cgcgcttgga ccccgaagcc 360
tatggctccc cgtgcgcgcg cggctcgcag ccctggcagg tctcgctctt caacggcctc 420
tcgttccact gcgcgggtgt cctggtggac cagagttggg tgctgacggc cgcgcactgc 480
ggaaacaagc cactgtgggc tcgagtaggg gatgaccacc tgctgcttct tcagggagag 540
cagctccgcc ggaccactcg ctctgttgtc catcccaagt accaccaggg ctcaggcccc 600
atcctgccaa ggcgaacgga tgagcacgat ctcatgttgc tgaagctggc caggcccgta 660
gtgctggggc cccgcgtccg ggccctgcag cttccctacc gctgtgctca gcccggagac 720
cagtgccagg ttgctggctg gggcaccacg gccgcccgga gagtgaagta caacaagggc 780
ctgacctgct ccagcatcac tatcctgagc cctaaagagt gtgaggtctt ctaccctggc 840
gtggtcacca acaacatgat atgtgctgga ctggaccggg gccaggaccc ttgccagagt 900
gactctggag gccccctggt ctgtgacgag accctccaag gcatcctctc gtggggtgtt 960
tacccctgtg gctctgccca gcatccagct gtctacaccc agatctgcaa atacatgtcc 1020
tggatcaata aagtcatacg ctccaactga tccagatgct acgctccagc tgatccagat 1080
gttatgctcc tgctgatcca gatgcccaga ggctccatcg tccatcctct tcctccccag 1140
tcggctgaac tctccccttg tctgcactgt tcaaacctct gccgccctcc acacctctaa 1200
acatctcccc tctcacctca ttcccccacc tatccccatt ctctgcctgt actgaagctg 1260
aaatgcagga agtggtggca aaggtttatt ccagagaagc caggaagccg gtcatcaccc 1320
agcctctgag agcagttact ggggtcaccc aacctgactt cctctgccac tccctgctgt 1380
gtgactttgg gcaagccaag tgccctctct gaacctcagt ttcctcatct gcaaaatggg 1440
aacaatgacg tgcctacctc ttagacatgt tgtgaggaga ctatgatata acatgtgtat 1500
gtaaatcttc atggtgattg tcatgtaagg cttaacacag tgggtggtga gttctgacta 1560
aaggttacct gttgtcgtga 1580
<210>77
<211>1443
<212>DNA
<213>人类
<400>77
accagcggca gaccacaggc agggcagagg cacgtctggg tcccctccct ccttcctatc 60
ggcgactccc aggatcctgg ccatgagagc tccgcacctc cacctctccg ccgcctctgg 120
cgcccgggct ctggcgaagc tgctgccgct gctgatggcg caactctggg ccgcagaggc 180
ggcgctgctc ccccaaaacg acacgcgctt ggaccccgaa gcctatggct ccccgtgcgc 240
gcgcggctcg cagccctggc aggtctcgct cttcaacggc ctctcgttcc actgcgcggg 300
tgtcctggtg gaccagagtt gggtgctgac ggccgcgcac tgcggaaaca agccactgtg 360
ggctcgagta ggggatgacc acctgctgct tcttcaggga gagcagctcc gccggaccac 420
tcgctctgtt gtccatccca agtaccacca gggctcaggc cccatcctgc caaggcgaac 480
ggatgagcac gatctcatgt tgctgaagct ggccaggccc gtagtgctgg ggccccgcgt 540
ccgggccctg cagcttccct accgctgtgc tcagcccgga gaccagtgcc aggttgctgg 600
ctggggcacc acggccgccc ggagagtgaa gtacaacaag ggcctgacct gctccagcat 660
cactatcctg agccctaaag agtgtgaggt cttctaccct ggcgtggtca ccaacaacat 720
gatatgtgct ggactggacc ggggccagga cccttgccag agtgactctg gaggccccct 780
ggtctgtgac gagaccctcc aaggcatcct ctcgtggggt gtttacccct gtggctctgc 840
ccagcatcca gctgtctaca cccagatctg caaatacatg tcctggatca ataaagtcat 900
acgctccaac tgatccagat gctacgctcc agctgatcca gatgttatgc tcctgctgat 960
ccagatgccc agaggctcca tcgtccatcc tcttcctccc cagtcggctg aactctcccc 1020
ttgtctgcac tgttcaaacc tctgccgccc tccacacctc taaacatctc ccctctcacc 1080
tcattccccc acctatcccc attctctgcc tgtactgaag ctgaaatgca ggaagtggtg 1140
gcaaaggttt attccagaga agccaggaag ccggtcatca cccagcctct gagagcagtt 1200
actggggtca cccaacctga cttcctctgc cactccctgc tgtgtgactt tgggcaagcc 1260
aagtgccctc tctgaacctc agtttcctca tctgcaaaat gggaacaatg acgtgcctac 1320
ctcttagaca tgttgtgagg agactatgat ataacatgtg tatgtaaatc ttcatggtga 1380
ttgtcatgta aggcttaaca cagtgggtgg tgagttctga ctaaaggtta cctgttgtcg 1440
tga 1443
<210>78
<211>782
<212>DNA
<213>人类
<400>78
aggggcctta gcgtgccgca tcgccgagat ccagcgccca gagagacacc agagaaccca 60
ccatggcccc ctttgagccc ctggcttctg gcatcctgtt gttgctgtgg ctgatagccc 120
ccagcagggc ctgcacctgt gtcccacccc acccacagac ggccttctgc aattccgacc 180
tcgtcatcag ggccaagttc gtggggacac cagaagtcaa ccagaccacc ttataccagc 240
gttatgagat caagatgacc aagatgtata aagggttcca agccttaggg gatgccgctg 300
acatccggtt cgtctacacc cccgccatgg agagtgtctg cggatacttc cacaggtccc 360
acaaccgcag cgaggagttt ctcattgctg gaaaactgca ggatggactc ttgcacatca 420
ctacctgcag tttcgtggct ccctggaaca gcctgagctt agctcagcgc cggggcttca 480
ccaagaccta cactgttggc tgtgaggaat gcacagtgtt tccctgttta tccatcccct 540
gcaaactgca gagtggcact cattgcttgt ggacggacca gctcctccaa ggctctgaaa 600
agggcttcca gtcccgtcac cttgcctgcc tgcctcggga gccagggctg tgcacctggc 660
agtccctgcg gtcccagata gcctgaatcc tgcccggagt ggaactgaag cctgcacagt 720
gtccaccctg ttcccactcc catctttctt ccggacaatg aaataaagag ttaccaccca 780
gc 782
<210>79
<211>3178
<212>DNA
<213>人类
<400>79
gttgcctgtc tctaaacccc tccacattcc cgcggtcctt cagactgccc ggagagcgcg 60
ctctgcctgc cgcctgcctg cctgccactg agggttccca gcaccatgag ggcctggatc 120
ttctttctcc tttgcctggc cgggagggcc ttggcagccc ctcagcaaga agccctgcct 180
gatgagacag aggtggtgga agaaactgtg gcagaggtga ctgaggtatc tgtgggagct 240
aatcctgtcc aggtggaagt aggagaattt gatgatggtg cagaggaaac cgaagaggag 300
gtggtggcgg aaaatccctg ccagaaccac cactgcaaac acggcaaggt gtgcgagctg 360
gatgagaaca acacccccat gtgcgtgtgc caggacccca ccagctgccc agcccccatt 420
ggcgagtttg agaaggtgtg cagcaatgac aacaagacct tcgactcttc ctgccacttc 480
tttgccacaa agtgcaccct ggagggcacc aagaagggcc acaagctcca cctggactac 540
atcgggcctt gcaaatacat ccccccttgc ctggactctg agctgaccga attccccctg 600
cgcatgcggg actggctcaa gaacgtcctg gtcaccctgt atgagaggga tgaggacaac 660
aaccttctga ctgagaagca gaagctgcgg gtgaagaaga tccatgagaa tgagaagcgc 720
ctggaggcag gagaccaccc cgtggagctg ctggcccggg acttcgagaa gaactataac 780
atgtacatct tccctgtaca ctggcagttc ggccagctgg accagcaccc cattgacggg 840
tacctctccc acaccgagct ggctccactg cgtgctcccc tcatccccat ggagcattgc 900
accacccgct ttttcgagac ctgtgacctg gacaatgaca agtacatcgc cctggatgag 960
tgggccggct gcttcggcat caagcagaag gatatcgaca aggatcttgt gatctaaatc 1020
cactccttcc acagtaccgg attctctctt taaccctccc cttcgtgttt cccccaatgt 1080
ttaaaatgtt tggatggttt gttgttctgc ctggagacaa ggtgctaaca tagatttaag 1140
tgaatacatt aacggtgcta aaaatgaaaa ttctaaccca agacatgaca ttcttagctg 1200
taacttaact attaaggcct tttccacacg cattaatagt cccatttttc tcttgccatt 1260
tgtagctttg cccattgtct tattggcaca tgggtggaca cggatctgct gggctctgcc 1320
ttaaacacac attgcagctt caacttttct ctttagtgtt ctgtttgaaa ctaatactta 1380
ccgagtcaga ctttgtgttc atttcatttc agggtcttgg ctgcctgtgg gcttccccag 1440
gtggcctgga ggtgggcaaa gggaagtaac agacacacga tgttgtcaag gatggttttg 1500
ggactagagg ctcagtggtg ggagagatcc ctgcagaacc caccaaccag aacgtggttt 1560
gcctgaggct gtaactgaga gaaagattct ggggctgtgt tatgaaaata tagacattct 1620
cacataagcc cagttcatca ccatttcctc ctttaccttt cagtgcagtt tcttttcaca 1680
ttaggctgtt ggttcaaact tttgggagca cggactgtca gttctctggg aagtggtcag 1740
cgcatcctgc agggcttctc ctcctctgtc ttttggagaa ccagggctct tctcaggggc 1800
tctagggact gccaggctgt ttcagccagg aaggccaaaa tcaagagtga gatgtagaaa 1860
gttgtaaaat agaaaaagtg gagttggtga atcggttgtt ctttcctcac atttggatga 1920
ttgtcataag gtttttagca tgttcctcct tttcttcacc ctcccctttt ttcttctatt 1980
aatcaagaga aacttcaaag ttaatgggat ggtcggatct cacaggctga gaactcgttc 2040
acctccaagc atttcatgaa aaagctgctt cttattaatc atacaaactc tcaccatgat 2100
gtgaagagtt tcacaaatcc ttcaaaataa aaagtaatga cttagaaact gccttcctgg 2160
gtgatttgca tgtgtcttag tcttagtcac cttattatcc tgacacaaaa acacatgagc 2220
atacatgtct acacatgact acacaaatgc aaacctttgc aaacacatta tgcttttgca 2280
cacacacacc tgtacacaca caccggcatg tttatacaca gggagtgtat ggttcctgta 2340
agcactaagt tagctgtttt catttaatga cctgtggttt aacccttttg atcactacca 2400
ccattatcag caccagactg agcagctata tccttttatt aatcatggtc attcattcat 2460
tcattcattc acaaaatatt tatgatgtat ttactctgca ccaggtccca tgccaagcac 2520
tggggacaca gttatggcaa agtagacaaa gcatttgttc atttggagct tagagtccag 2580
gaggaataca ttagataatg acacaatcaa atataaattg caagatgtca caggtgtgat 2640
gaagggagag taggagagac catgagtatg tgtaacagga ggacacagca ttattctagt 2700
gctgtactgt tccgtacggc agccactacc cacatgtaac tttttaagat ttaaatttaa 2760
attagttaac attcaaaacg cagctcccca atcacactag caacatttca agtgcttgag 2820
agccatgcat gattagtggt taccctattg aataggtcag aagtagaatc ttttcatcat 2880
cacagaaagt tctattggac agtgctcttc tagatcatca taagactaca gagcactttt 2940
caaagctcat gcatgttcat catgttagtg tcgtattttg agctggggtt ttgagactcc 3000
ccttagagat agagaaacag acccaagaaa tgtgctcaat tgcaatgggc cacataccta 3060
gatctccaga tgtcatttcc cctctcttat tttaagttat gttaagatta ctaaaacaat 3120
aaaagctcct aaaaaatcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 3178
<210>80
<211>2691
<212>DNA
<213>人类
<400>80
gcttgcccgt cggtcgctag ctcgctcggt gcgcgtcgtc ccgctccatg gcgctcttcg 60
tgcggctgct ggctctcgcc ctggctctgg ccctgggccc cgccgcgacc ctggcgggtc 120
ccgccaagtc gccctaccag ctggtgctgc agcacagcag gctccggggc cgccagcacg 180
gccccaacgt gtgtgctgtg cagaaggtta ttggcactaa taggaagtac ttcaccaact 240
gcaagcagtg gtaccaaagg aaaatctgtg gcaaatcaac agtcatcagc tacgagtgct 300
gtcctggata tgaaaaggtc cctggggaga agggctgtcc agcagcccta ccactctcaa 360
acctttacga gaccctggga gtcgttggat ccaccaccac tcagctgtac acggaccgca 420
cggagaagct gaggcctgag atggaggggc ccggcagctt caccatcttc gcccctagca 480
acgaggcctg ggcctccttg ccagctgaag tgctggactc cctggtcagc aatgtcaaca 540
ttgagctgct caatgccctc cgctaccata tggtgggcag gcgagtcctg actgatgagc 600
tgaaacacgg catgaccctc acctctatgt accagaattc caacatccag atccaccact 660
atcctaatgg gattgtaact gtgaactgtg cccggctcct gaaagccgac caccatgcaa 720
ccaacggggt ggtgcacctc atcgataagg tcatctccac catcaccaac aacatccagc 780
agatcattga gatcgaggac acctttgaga cccttcgggc tgctgtggct gcatcagggc 840
tcaacacgat gcttgaaggt aacggccagt acacgctttt ggccccgacc aatgaggcct 900
tcgagaagat ccctagtgag actttgaacc gtatcctggg cgacccagaa gccctgagag 960
acctgctgaa caaccacatc ttgaagtcag ctatgtgtgc tgaagccatc gttgcggggc 1020
tgtctgtaga gaccctggag ggcacgacac tggaggtggg ctgcagcggg gacatgctca 1080
ctatcaacgg gaaggcgatc atctccaata aagacatcct agccaccaac ggggtgatcc 1140
actacattga tgagctactc atcccagact cagccaagac actatttgaa ttggctgcag 1200
agtctgatgt gtccacagcc attgaccttt tcagacaagc cggcctcggc aatcatctct 1260
ctggaagtga gcggttgacc ctcctggctc ccctgaattc tgtattcaaa gatggaaccc 1320
ctccaattga tgcccataca aggaatttgc ttcggaacca cataattaaa gaccagctgg 1380
cctctaagta tctgtaccat ggacagaccc tggaaactct gggcggcaaa aaactgagag 1440
tttttgttta tcgtaatagc ctctgcattg agaacagctg catcgcggcc cacgacaaga 1500
gggggaggta cgggaccctg ttcacgatgg accgggtgct gaccccccca atggggactg 1560
tcatggatgt cctgaaggga gacaatcgct ttagcatgct ggtagctgcc atccagtctg 1620
caggactgac ggagaccctc aaccgggaag gagtctacac agtctttgct cccacaaatg 1680
aagccttccg agccctgcca ccaagagaac ggagcagact cttgggagat gccaaggaac 1740
ttgccaacat cctgaaatac cacattggtg atgaaatcct ggttagcgga ggcatcgggg 1800
ccctggtgcg gctaaagtct ctccaaggtg acaagctgga agtcagcttg aaaaacaatg 1860
tggtgagtgt caacaaggag cctgttgccg agcctgacat catggccaca aatggcgtgg 1920
tccatgtcat caccaatgtt ctgcagcctc cagccaacag acctcaggaa agaggggatg 1980
aacttgcaga ctctgcgctt gagatcttca aacaagcatc agcgttttcc agggcttccc 2040
agaggtctgt gcgactagcc cctgtctatc aaaagttatt agagaggatg aagcattagc 2100
ttgaagcact acaggaggaa tgcaccacgg cagctctccg ccaatttctc tcagatttcc 2160
acagagactg tttgaatgtt ttcaaaacca agtatcacac tttaatgtac atgggccgca 2220
ccataatgag atgtgagcct tgtgcatgtg ggggaggagg gagagagatg tactttttaa 2280
atcatgttcc ccctaaacat ggctgttaac ccactgcatg cagaaacttg gatgtcactg 2340
cctgacattc acttccagag aggacctatc ccaaatgtgg aattgactgc ctatgccaag 2400
tccctggaaa aggagcttca gtattgtggg gctcataaaa catgaatcaa gcaatccagc 2460
ctcatgggaa gtcctggcac agtttttgta aagcccttgc acagctggag aaatggcatc 2520
attataagct atgagttgaa atgttctgtc aaatgtgtct cacatctaca cgtggcttgg 2580
aggcttttat ggggccctgt ccaggtagaa aagaaatggt atgtagagct tagatttccc 2640
tattgtgaca gagccatggt gtgtttgtaa taataaaacc aaagaaacat a 2691
<210>81
<211>1757
<212>DNA
<213>人类
<400>81
caagcttggc acgagggcag gcattgcccg agccagccga gccgccagag ccgcgggccg 60
cgcgggtgtc gcgggcccaa ccccaggatg ctcccctgcg cctcctgcct acccgggtct 120
ctactgctct gggcgctgct actgttgctc ttgggatcag cttctcctca ggattctgaa 180
gagcccgaca gctacacgga atgcacagat ggctatgagt gggacccaga cagccagcac 240
tgccgggatg tcaacgagtg tctgaccatc cctgaggcct gcaaggggga aatgaagtgc 300
atcaaccact acgggggcta cttgtgcctg ccccgctccg ctgccgtcat caacgaccta 360
cacggcgagg gacccccgcc accagtgcct cccgctcaac accccaaccc ctgcccacca 420
ggctatgagc ccgacgatca ggacagctgt gtggatgtgg acgagtgtgc ccaggccctg 480
cacgactgtc gccccagcca ggactgccat aacttgcctg gctcctatca gtgcacctgc 540
cctgatggtt accgcaagat cgggcccgag tgtgtggaca tagacgagtg ccgctaccgc 600
tactgccagc accgctgcgt gaacctgcct ggctccttcc gctgccagtg cgagccgggc 660
ttccagctgg ggcctaacaa ccgctcctgt gttgatgtga acgagtgtga catgggggcc 720
ccatgcgagc agcgctgctt caactcctat gggaccttcc tgtgtcgctg ccaccagggc 780
tatgagctgc atcgggatgg cttctcctgc agtgatattg atgagtgtag ctactccagc 840
tacctctgtc agtaccgctg cgtcaacgag ccaggccgtt tctcctgcca ctgcccacag 900
ggttaccagc tgctggccac acgcctctgc caagacattg atgagtgtga gtctggtgcg 960
caccagtgct ccgaggccca aacctgtgtc aacttccatg ggggctaccg ctgcgtggac 1020
accaaccgct gcgtggagcc ctacatccag gtctctgaga accgctgtct ctgcccggcc 1080
tccaaccctc tatgtcgaga gcagccttca tccattgtgc accgctacat gaccatcacc 1140
tcggagcgga gagtacccgc tgacgtgttc cagatccagg cgacctccgt ctaccccggt 1200
gcctacaatg cctttcagat ccgtgctgga aactcgcagg gggactttta cattaggcaa 1260
atcaacaacg tcagcgccat gctggtcctc gcccggccgg tgacgggccc ccgggagtac 1320
gtgctggacc tggagatggt caccatgaat tccctcatga gctaccgggc cagctctgta 1380
ctgaggctca ccgtctttgt aggggcctac accttctgag gagcaggagg gagccaccct 1440
ccctgcagct accctagctg aggagcctgt tgtgaggggc agaatgagaa aggcccaggg 1500
gcccccattg acaggagctg ggagctctgc accacgagct tcagtcaccc cgagaggaga 1560
ggaggtaacg aggagggcgg actccaggcc ccggcccaga gatttggact tggctggctt 1620
gcaggggtcc taagaaactc cactctggac agcgccagga ggccctgggt tccattccta 1680
actctgcctc aaactgtaca tttggataag ccctagtagt tccctgggcc tgtttttcta 1740
taaaacgagg caactgg 1757
<210>82
<211>1804
<212>DNA
<213>人类
<400>82
gtatcactca gaatctggca gccagttccg tcctgacaga gttcacagca tatattggtg 60
gattcttgtc catagtgcat ctgctttaag aattaacgaa agcagtgtca agacagtaag 120
gattcaaacc atttgccaaa aatgagtcta agtgcattta ctctcttcct ggcattgatt 180
ggtggtacca gtggccagta ctatgattat gattttcccc tatcaattta tgggcaatca 240
tcaccaaact gtgcaccaga atgtaactgc cctgaaagct acccaagtgc catgtactgt 300
gatgagctga aattgaaaag tgtaccaatg gtgcctcctg gaatcaagta tctttacctt 360
aggaataacc agattgacca tattgatgaa aaggcctttg agaatgtaac tgatctgcag 420
tggctcattc tagatcacaa ccttctagaa aactccaaga taaaagggag agttttctct 480
aaattgaaac aactgaagaa gctgcatata aaccacaaca acctgacaga gtctgtgggc 540
ccacttccca aatctctgga ggatctgcag cttactcata acaagatcac aaagctgggc 600
tcttttgaag gattggtaaa cctgaccttc atccatctcc agcacaatcg gctgaaagag 660
gatgctgttt cagctgcttt taaaggtctt aaatcactcg aataccttga cttgagcttc 720
aatcagatag ccagactgcc ttctggtctc cctgtctctc ttctaactct ctacttagac 780
aacaataaga tcagcaacat ccctgatgag tatttcaagc gttttaatgc attgcagtat 840
ctgcgtttat ctcacaacga actggctgat agtggaatac ctggaaattc tttcaatgtg 900
tcatccctgg ttgagctgga tctgtcctat aacaagctta aaaacatacc aactgtcaat 960
gaaaaccttg aaaactatta cctggaggtc aatcaacttg agaagtttga cataaagagc 1020
ttctgcaaga tcctggggcc attatcctac tccaagatca agcatttgcg tttggatggc 1080
aatcgcatct cagaaaccag tcttccaccg gatatgtatg aatgtctacg tgttgctaac 1140
gaagtcactc ttaattaata tctgtatcct ggaacaatat tttatggtta tgtttttctg 1200
tgtgtcagtt ttcatagtat ccatatttta ttactgttta ttacttccat gaattttaaa 1260
atctgaggga aatgttttgt aaacatttat tttttttaaa gaaaagatga aaggcaggcc 1320
tatttcatca caagaacaca cacatataca cgaatagaca tcaaactcaa tgctttattt 1380
gtaaatttag tgttttttta tttctactgt caaatgatgt gcaaaacctt ttactggttg 1440
catggaaatc agccaagttt tataatcctt aaatcttaat gttcctcaaa gcttggatta 1500
aatacatatg gatgttactc tcttgcacca aattatcttg atacattcaa atttgtctgg 1560
ttaaaaaata ggtggtagat attgaggcca agaatattgc aaaatacatg aagcttcatg 1620
cacttaaaga agtattttta gaataagaat ttgcatactt acctagtgaa acttttctag 1680
aattattttt cactctaagt catgtatgtt tctctttgat tatttgcatg ttatgtttaa 1740
taagctacta gcaaaataaa acatagcaaa tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1800
aaaa 1804
<210>83
<211>3290
<212>DNA
<213>人类
<400>83
agcggggccg gaccgggcgg gcggagccgg gcccgcgggg ctgctgcggg gcgatcgggc 60
cgggccgctg ccgcgccatg gactcccgtg tccagcctga gttccagcct cactgagtgg 120
ccacccccaa agtgctgcca gccgaggaag cccccagcac tgaccatgtc tattatggac 180
cacagcccca ccacgggcgt ggtcacagtc atcgtcatcc tcattgccat cgcggccctg 240
ggggccttga tcctgggctg ctggtgctac ctgcggctgc agcgcatcag ccagtcagag 300
gacgaggaga gcatcgtggg ggatggggag accaaggaac ccttcctgct ggtgcagtat 360
tcggccaagg gaccgtgcgt ggagagaaag gccaagctga tgactcccaa cggcccggaa 420
gtccacggct gagccaggat gcaaggctcc tggtcctgtt tgcagccggc caagaggcgc 480
tgggaggggc aaaaccatac ggatgcgctg ctgtctgaga ggaagggctg acacttgctg 540
gcatggcctc tgcgggcttc gtcatcgcat gcactgatgc ccggggacct ggctgtcctg 600
ggcttcccct cggcctccag gtgaggctgc ccattgcagg cactgggcag gcctgacctt 660
gctggggctc atggccctgt agcgcttttg ttacttgaat gtctagctga gcctgttttt 720
gatggagcta ctactgtaat gcgtgaacta acaaacctgt gaactgtaaa taggcccctg 780
gaagcacgtg cttaagccct tttgctgatt tttaaaaata tcatctagcg cacacgggac 840
tggtattctg gctgtactaa tgacaagctg agtcaagacc ctggagggtc ataggcttgt 900
aaaggcccac gccacactcg gcaggggtct ctcatgtgtg tccatctgcg tgtatgtcaa 960
ggaagtgaga tgccaatttg gggtcttgag gctgaccagt tggggtgctt gggtgatctc 1020
tgcttcatta gtcatgggtg gaagaaaaac cacacccccc gcacccctcc gttctttctg 1080
catagactca cttgttaaat agcagttctg ttgagagtgg agttactgca gggaagctac 1140
cggacctgcc tgggagccag tgaagggcga gtcagggcac gcgtcctgga ggctgccagc 1200
gtccttgtag cagagcagtt tcttgccgct tgggtcttca gcacgccaag ccccccacca 1260
accctccacc ccgagtgaag gcttcgctga aattgctttg gtcctcatag agcctgtggt 1320
ggctactttt ggtctgaaac ccacttggcc caggaaagag aaaaggttgt atgttttgtg 1380
ttggtgtttc ctattttctg cactggaggg gaggggactg ttgaggttct gtcttttttc 1440
ttcttttcct cttccctctt cacatcactt ggcttccttt cctctctgat gaccgtccgc 1500
ctatggggtt ctgacttcac tttcctcagc gggtctccag tcccctgacc cagctctaaa 1560
ggcacttagg acccagggaa catttctcac gtgcacattc ccctaagagc caccagactg 1620
cttcctgcca gcctgtgctt gcggcaggga gccggggcag ggcagaggtg aacttgaagt 1680
tcaggacttg actctcccac aggtggtgag ctggtggctc tctggtgagc tagtgtctcc 1740
acagcctgtc tccaaggcct cccctatgta catttcagtg agctcacttt gatttttaat 1800
cccaccacaa gcacatacta attttattta tgattcaaat gtgactcgtg cctgcccatc 1860
cctgtaatag atggaaggtc agccccggct taaccacaga gcactggccc ttcatggctg 1920
agctcagagc tctggcctcc tgctcagact aaaggcacct cctctggcct cacccaagcc 1980
tcttctaaaa accatgttga atgaatccac gttctggaac cccgaggcgg gagaagtagg 2040
gagctgttcg tttaagcagc atacacctaa attgggggtt taaacattaa gtaggagctt 2100
ggggtggaag agggacagcc ggctgggcca cctgagcaga aggtggtaat gaaacacctc 2160
agctgggctc ttgggagacc ttaggaagca ggagaggcaa cacctctggc tactgatggt 2220
gtggcaagtt cagaagaggt ggtggtgggg taggcgtgat gtcagcagaa gccctgcagg 2280
ctgggtgggc aggacacgtg gtgggggcca ctgaaaccag gcctaggagg gagaacaagt 2340
tccaaaggtg ccgactggaa gaagggggta aaagtttgct ttggtgagtg agaaaaggct 2400
ggggcgtgtg atccatcccc tcacgtttca gaacttccag gctttctacc tcgactctca 2460
ccacagccag cacatacacc taggctgttt ttccttcctc cacacctgag ggacgcagca 2520
acagctagga tctgcatttt caggttccga gcctgacccc tggaactgac cagcgctcga 2580
ttgtcagcct tggcctgggg ttttgacctt gccagtgaag tttcggtttt gaagtgatta 2640
aatgtcactt cctcatcagt tttacttctg gaggttttct tatcctactc cctggtgcca 2700
gggacgtacc tgggagtttg aatcaggccc atttgagcgt ggcagccgtg ttgggtgaag 2760
gtccggggct cggtgaggca ctgggggggt tttcgggagg aaaatgaaaa tgcttctaga 2820
atgagtgaac cacatcatag ctctcactgt tttttcaata gctacttttt ttagcagaca 2880
ccagagccac actcaaatgg ctaagtaggt tatgacctct ctggattatt tttgaatgcc 2940
caactgttgc attcaagttt tctgactaat aagaaattaa gcattcatcc ttcgtatcac 3000
tgcagaagca acagtggggg cacagggagg gaactcttga cactgagcca ctaaaatatg 3060
gactaatttt ttggacaaat cttcaaacgg actgtgctac tgtatttgtc tcaaagctac 3120
caagtttgtg caataagtgg aagggatgtc atccttcttc aataaatgct gaatgacatt 3180
caagctgatt ttctagacca ctgagaaaat ctttatttac aataaatttc aataaaattt 3240
gcataaatat attcccaaaa aaaaaaaaaa aaaaaaagaa aaaaaaaaaa 3290
<210>84
<211>1616
<212>DNA
<213>人类
<400>84
ctccctgtgt tggtggagga tgtctgcagc agcatttaaa ttctgggagg gcttggttgt 60
cagcagcagc aggaggaggc agagcacagc atcgtcggga ccagactcgt ctcaggccag 120
ttgcagcctt ctcagccaaa cgccgaccaa ggaaaactca ctaccatgag aattgcagtg 180
atttgctttt gcctcctagg catcacctgt gccataccag ttaaacaggc tgattctgga 240
agttctgagg aaaagcagct ttacaacaaa tacccagatg ctgtggccac atggctaaac 300
cctgacccat ctcagaagca gaatctccta gccccacaga cccttccaag taagtccaac 360
gaaagccatg accacatgga tgatatggat gatgaagatg atgatgacca tgtggacagc 420
caggactcca ttgactcgaa cgactctgat gatgtagatg acactgatga ttctcaccag 480
tctgatgagt ctcaccattc tgatgaatct gatgaactgg tcactgattt tcccacggac 540
ctgccagcaa ccgaagtttt cactccagtt gtccccacag tagacacata tgatggccga 600
ggtgatagtg tggtttatgg actgaggtca aaatctaaga agtttcgcag acctgacatc 660
cagtaccctg atgctacaga cgaggacatc acctcacaca tggaaagcga ggagttgaat 720
ggtgcataca aggccatccc cgttgcccag gacctgaacg cgccttctga ttgggacagc 780
cgtgggaagg acagttatga aacgagtcag ctggatgacc agagtgctga aacccacagc 840
cacaagcagt ccagattata taagcggaaa gccaatgatg agagcaatga gcattccgat 900
gtgattgata gtcaggaact ttccaaagtc agccgtgaat tccacagcca tgaatttcac 960
agccatgaag atatgctggt tgtagacccc aaaagtaagg aagaagataa acacctgaaa 1020
tttcgtattt ctcatgaatt agatagtgca tcttctgagg tcaattaaaa ggagaaaaaa 1080
tacaatttct cactttgcat ttagtcaaaa gaaaaaatgc tttatagcaa aatgaaagag 1140
aacatgaaat gcttctttct cagtttattg gttgaatgtg tatctatttg agtctggaaa 1200
taactaatgt gtttgataat tagtttagtt tgtggcttca tggaaactcc ctgtaaacta 1260
aaagcttcag ggttatgtct atgttcattc tatagaagaa atgcaaacta tcactgtatt 1320
ttaatatttg ttattctctc atgaatagaa atttatgtag aagcaaacaa aatactttta 1380
cccacttaaa aagagaatat aacattttat gtcactataa tcttttgttt tttaagttag 1440
tgtatatttt gttgtgatta tctttttgtg gtgtgaataa atcttttatc ttgaatgtaa 1500
taagaatttg gtggtgtcaa ttgcttattt gttttcccac ggttgtccag caattaataa 1560
aacataacct tttttactgc ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 1616
<210>85
<211>11185
<212>DNA
<213>人类
<400>85
gctgccccga gcctttctgg ggaagaactc caggcgtgcg gacgcaacag ccgagaacat 60
taggtgttgt ggacaggagc tgggaccaag atcttcggcc agccccgcat cctcccgcat 120
cttccagcac cgtcccgcac cctccgcatc cttccccggg ccaccacgct tcctatgtga 180
cccgcctggg caacgccgaa cccagtcgcg cagcgctgca gtgaattttc cccccaaact 240
gcaataagcc gccttccaag gccaagatgt tcataaatat aaagagcatc ttatggatgt 300
gttcaacctt aatagtaacc catgcgctac ataaagtcaa agtgggaaaa agcccaccgg 360
tgaggggctc cctctctgga aaagtcagcc taccttgtca tttttcaacg atgcctactt 420
tgccacccag ttacaacacc agtgaatttc tccgcatcaa atggtctaag attgaagtgg 480
acaaaaatgg aaaagatttg aaagagacta ctgtccttgt ggcccaaaat ggaaatatca 540
agattggtca ggactacaaa gggagagtgt ctgtgcccac acatcccgag gctgtgggcg 600
atgcctccct cactgtggtc aagctgctgg caagtgatgc gggtctttac cgctgtgacg 660
tcatgtacgg gattgaagac acacaagaca cggtgtcact gactgtggat ggggttgtgt 720
ttcactacag ggcggcaacc agcaggtaca cactgaattt tgaggctgct cagaaggctt 780
gtttggacgt tggggcagtc atagcaactc cagagcagct ctttgctgcc tatgaagatg 840
gatttgagca gtgtgacgca ggctggctgg ctgatcagac tgtcagatat cccatccggg 900
ctcccagagt aggctgttat ggagataaga tgggaaaggc aggagtcagg acttatggat 960
tccgttctcc ccaggaaact tacgatgtgt attgttatgt ggatcatctg gatggtgatg 1020
tgttccacct cactgtcccc agtaaattca ccttcgagga ggctgcaaaa gagtgtgaaa 1080
accaggatgc caggctggca acagtggggg aactccaggc ggcatggagg aacggctttg 1140
accagtgcga ttacgggtgg ctgtcggatg ccagcgtgcg ccaccctgtg actgtggcca 1200
gggcccagtg tggaggtggt ctacttgggg tgagaaccct gtatcgtttt gagaaccaga 1260
caggcttccc tccccctgat agcagatttg atgcctactg ctttaaacct aaagaggcta 1320
caaccatcga tttgagtatc ctcgcagaaa ctgcatcacc cagtttatcc aaagaaccac 1380
aaatggtttc tgatagaact acaccaatca tccctttagt tgatgaatta cctgtcattc 1440
caacagagtt ccctcccgtg ggaaatattg tcagttttga acagaaagcc acagtccaac 1500
ctcaggctat cacagatagt ttagccacca aattacccac acctactggc agtaccaaga 1560
agccctggga tatggatgac tactcacctt ctgcttcagg acctcttgga aagctagaca 1620
tatcagaaat taaggaagaa gtgctccaga gtacaactgg cgtctctcat tatgctacgg 1680
attcatggga tggtgtcgtg gaagataaac aaacacaaga atcggttaca cagattgaac 1740
aaatagaagt gggtcctttg gtaacatcta tggaaatctt aaagcacatt ccttccaagg 1800
aattccctgt aactgaaaca ccattggtaa ctgcaagaat gatcctggaa tccaaaactg 1860
aaaagaaaat ggtaagcact gtttctgaat tggtaaccac aggtcactat ggattcacct 1920
tgggagaaga ggatgatgaa gacagaacac ttacagttgg atctgatgag agcaccttga 1980
tctttgacca aattcctgaa gtcattacgg tgtcaaagac ttcagaagac accatccaca 2040
ctcatttaga agacttggag tcagtctcag catccacaac tgtttcccct ttaattatgc 2100
ctgataataa tggatcatcc atggatgact gggaagagag acaaactagt ggtaggataa 2160
cggaagagtt tcttggcaaa tatctgtcta ctacaccttt tccatcacag catcgtacag 2220
aaatagaatt gtttccttat tctggtgata aaatattagt agagggaatt tccacagtta 2280
tttatccttc tctacaaaca gaaatgacac atagaagaga aagaacagaa acactaatac 2340
cagagatgag aacagatact tatacagatg aaatacaaga agagatcact aaaagtccat 2400
ttatgggaaa aacagaagaa gaagtcttct ctgggatgaa actctctaca tctctctcag 2460
agccaattca tgttacagag tcttctgtgg aaatgaccaa gtcttttgat ttcccaacat 2520
tgataacaaa gttaagtgca gagccaacag aagtaagaga tatggaggaa gactttacag 2580
caactccagg tactacaaaa tatgatgaaa atattacaac agtgcttttg gcccatggta 2640
ctttaagtgt tgaagcagcc actgtatcaa aatggtcatg ggatgaagat aatacaacat 2700
ccaagccttt agagtctaca gaaccttcag cctcttcaaa attgccccct gccttactca 2760
caactgtggg gatgaatgga aaggataaag acatcccaag tttcactgaa gatggagcag 2820
atgaatttac tcttattcca gatagtactc aaaagcagtt agaggaggtt actgatgaag 2880
acatagcagc ccatggaaaa ttcacaatta gatttcagcc aactacatca actggtattg 2940
cagaaaagtc aactttgaga gattctacaa ctgaagaaaa agttccacct atcacaagca 3000
ctgaaggcca agtttatgca accatggaag gaagtgcttt gggtgaagta gaagatgtgg 3060
acctctctaa gccagtatct actgttcccc aatttgcaca cacttcagag gtggaaggat 3120
tagcatttgt tagttatagt agcacccaag agcctactac ttatgtagac tcttcccata 3180
ccattcctct ttctgtaatt cccaagacag actggggagt gttagtacct tctgttccat 3240
cagaagatga agttctaggt gaaccctctc aagacatact tgtcattgat cagactcgcc 3300
ttgaagcgac tatttctcca gaaactatga gaacaacaaa aatcacagag ggaacaactc 3360
aggaagaatt cccttggaaa gaacagactg cagagaaacc agttcctgct ctcagttcta 3420
cagcttggac tcccaaggag gcagtaacac cactggatga acaagagggc gatggatcag 3480
catatacagt ctctgaagat gaattgttga caggttctga gagggtccca gttttagaaa 3540
caactccagt tggaaaaatt gatcacagtg tgtcttatcc accaggtgct gtaactgagc 3600
acaaagtgaa aacagatgaa gtggtaacac taacaccacg cattgggcca aaagtatctt 3660
taagtccagg gcctgaacaa aaatatgaaa cagaaggtag tagtacaaca ggatttacat 3720
catctttgag tccttttagt acccacatta cccagcttat ggaagaaacc actactgaga 3780
aaacatccct agaggatatt gatttaggct caggattatt tgaaaagccc aaagccacag 3840
aactcataga attttcaaca atcaaagtca cagttccaag tgatattacc actgccttca 3900
gttcagtaga cagacttcac acaacttcag cattcaagcc atcttccgcg atcactaaga 3960
aaccacctct catcgacagg gaacctggtg aagaaacaac cagtgacatg gtaatcattg 4020
gagaatcaac atctcatgtt cctcccacta cccttgaaga tattgtagcc aaggaaacag 4080
aaaccgatat tgatagagag tatttcacga cttcaagtcc tcctgctaca cagccaacaa 4140
gaccacccac tgtggaagac aaagaggcct ttggacctca ggcgctttct acgccacagc 4200
ccccagcaag cacaaaattt caccctgaca ttaatgttta tattattgag gtcagagaaa 4260
ataagacagg tcgaatgagt gatttgagtg taattggtca tccaatagat tcagaatcta 4320
aagaagatga accttgtagt gaagaaacag atccagtgca tgatctaatg gctgaaattt 4380
tacctgaatt ccctgacata attgaaatag acctatacca cagtgaagaa aatgaagaag 4440
aagaagaaga gtgtgcaaat gctactgatg tgacaaccac cccatctgtg cagtacataa 4500
atgggaagca tctcgttacc actgtgccca aggacccaga agctgcagaa gctaggcgtg 4560
gccagtttga aagtgttgca ccttctcaga atttctcgga cagctctgaa agtgatactc 4620
atccatttgt aatagccaaa acggaattgt ctactgctgt gcaacctaat gaatctacag 4680
aaacaactga gtctcttgaa gttacatgga agcctgagac ttaccctgaa acatcagaac 4740
atttttcagg tggtgagcct gatgttttcc ccacagtccc attccatgag gaatttgaaa 4800
gtggaacagc caaaaaaggg gcagaatcag tcacagagag agatactgaa gttggtcatc 4860
aggcacatga acatactgaa cctgtatctc tgtttcctga agagtcttca ggagagattg 4920
ccattgacca agaatctcag aaaatagcct ttgcaagggc tacagaagta acatttggtg 4980
aagaggtaga aaaaagtact tctgtcacat acactcccac tatagttcca agttctgcat 5040
cagcatatgt ttcagaggaa gaagcagtta ccctaatagg aaatccttgg ccagatgacc 5100
tgttgtctac caaagaaagc tgggtagaag caactcctag acaagttgta gagctctcag 5160
ggagttcttc gattccaatt acagaaggct ctggagaagc agaagaagat gaagatacaa 5220
tgttcaccat ggtaactgat ttatcacaga gaaatactac tgatacactc attactttag 5280
acactagcag gataatcaca gaaagctttt ttgaggttcc tgcaaccacc atttatccag 5340
tttctgaaca accttctgca aaagtggtgc ctaccaagtt tgtaagtgaa acagacactt 5400
ctgagtggat ttccagtacc actgttgagg aaaagaaaag gaaggaggag gagggaacta 5460
caggtacggc ttctacattt gaggtatatt catctacaca gagatcggat caattaattt 5520
taccctttga attagaaagt ccaaatgtag ctacatctag tgattcaggt accaggaaaa 5580
gttttatgtc cttgacaaca ccaacacagt ctgaaaggga aatgacagat tctactcctg 5640
tctttacaga aacaaataca ttagaaaatt tgggggcaca gaccactgag cacagcagta 5700
tccatcaacc tggggttcag gaagggctga ccactctccc acgtagtcct gcctctgtct 5760
ttatggagca gggctctgga gaagctgctg ccgacccaga aaccaccact gtttcttcat 5820
tttcattaaa cgtagagtat gcaattcaag ccgaaaagga agtagctggc actttgtctc 5880
cgcatgtgga aactacattc tccactgagc caacaggact ggttttgagt acagtaatgg 5940
acagagtagt tgctgaaaat ataacccaaa catccaggga aatagtgatt tcagagcgat 6000
taggagaacc aaattatggg gcagaaataa ggggcttttc cacaggtttt cctttggagg 6060
aagatttcag tggtgacttt agagaatact caacagtgtc tcatcccata gcaaaagaag 6120
aaacggtaat gatggaaggc tctggagatg cagcatttag ggacacccag acttcaccat 6180
ctacagtacc tacttcagtt cacatcagtc acatatctga ctcagaagga cccagtagca 6240
ccatggtcag cacttcagcc ttcccctggg aagagtttac atcctcagct gagggctcag 6300
gtgagcaact ggtcacagtc agcagctctg ttgttccagt gcttcccagt gctgtgcaaa 6360
agttttctgg tacagcttcc tccattatcg acgaaggatt gggagaagtg ggtactgtca 6420
atgaaattga tagaagatcc accattttac caacagcaga agtggaaggt acgaaagctc 6480
cagtagagaa ggaggaagta aaggtcagtg gcacagtttc aacaaacttt ccccaaacta 6540
tagagccagc caaattatgg tctaggcaag aagtcaaccc tgtaagacaa gaaattgaaa 6600
gtgaaacaac atcagaggaa caaattcaag aagaaaagtc atttgaatcc cctcaaaact 6660
ctcctgcaac agaacaaaca atctttgatt cacagacatt tactgaaact gaactcaaaa 6720
ccacagatta ttctgtacta acaacaaaga aaacttacag tgatgataaa gaaatgaagg 6780
aggaagacac ttctttagtt aacatgtcta ctccagatcc agatgcaaat ggcttggaat 6840
cttacacaac tctccctgaa gctactgaaa agtcacattt tttcttagct actgcattag 6900
taactgaatc tataccagct gaacatgtag tcacagattc accaatcaaa aaggaagaaa 6960
gtacaaaaca ttttccgaaa ggcatgagac caacaattca agagtcagat actgagctct 7020
tattctctgg actgggatca ggagaagaag ttttacctac tctaccaaca gagtcagtga 7080
attttactga agtggaacaa atcaataaca cattatatcc ccacacttct caagtggaaa 7140
gtacctcaag tgacaaaatt gaagacttta acagaatgga aaatgtggca aaagaagttg 7200
gaccactcgt atctcaaaca gacatctttg aaggtagtgg gtcagtaacc agcacaacat 7260
taatagaaat tttaagtgac actggagcag aaggacccac ggtggcacct ctccctttct 7320
ccacggacat cggacatcct caaaatcaga ctgtcaggtg ggcagaagaa atccagacta 7380
gtagaccaca aaccataact gaacaagact ctaacaagaa ttcttcaaca gcagaaatta 7440
acgaaacaac aacctcatct actgattttc tggctagagc ttatggtttt gaaatggcca 7500
aagaatttgt tacatcagca ccaaaaccat ctgacttgta ttatgaacct tctggagaag 7560
gatctggaga agtggatatt gttgattcat ttcacacttc tgcaactact caggcaacca 7620
gacaagaaag cagcaccaca tttgtttctg atgggtccct ggaaaaacat cctgaggtgc 7680
caagcgctaa agctgttact gctgatggat tcccaacagt ttcagtgatg ctgcctcttc 7740
attcagagca gaacaaaagc tcccctgatc caactagcac actgtcaaat acagtgtcat 7800
atgagaggtc cacagacggt agtttccaag accgtttcag ggaattcgag gattccacct 7860
taaaacctaa cagaaaaaaa cccactgaaa atattatcat agacctggac aaagaggaca 7920
aggatttaat attgacaatt acagagagta ccatccttga aattctacct gagctgacat 7980
cggataaaaa tactatcata gatattgatc atactaaacc tgtgtatgaa gacattcttg 8040
gaatgcaaac agatatagat acagaggtac catcagaacc acatgacagt aatgatgaaa 8100
gtaatgatga cagcactcaa gttcaagaga tctatgaggc agctgtcaac ctttctttaa 8160
ctgaggaaac atttgagggc tctgctgatg ttctggctag ctacactcag gcaacacatg 8220
atgaatcaat gacttatgaa gatagaagcc aactagatca catgggcttt cacttcacaa 8280
ctgggatccc tgctcctagc acagaaacag aattagacgt tttacttccc acggcaacat 8340
ccctgccaat tcctcgtaag tctgccacag ttattccaga gattgaagga ataaaagctg 8400
aagcaaaagc cctggatgac atgtttgaat caagcacttt gtctgatggt caagctattg 8460
cagaccaaag tgaaataata ccaacattgg gccaatttga aaggactcag gaggagtatg 8520
aagacaaaaa acatgctggt ccttcttttc agccagaatt ctcttcagga gctgaggagg 8580
cattagtaga ccatactccc tatctaagta ttgctactac ccaccttatg gatcagagtg 8640
taacagaggt gcctgatgtg atggaaggat ccaatccccc atattacact gatacaacat 8700
tagcagtttc aacatttgcg aagttgtctt ctcagacacc atcatctccc ctcactatct 8760
actcaggcag tgaagcctct ggacacacag agatccccca gcccagtgct ctgccaggaa 8820
tagacgtcgg ctcatctgta atgtccccac aggattcttt taaggaaatt catgtaaata 8880
ttgaagcaac tttcaaacca tcaagtgagg aataccttca cataactgag cctccctctt 8940
tatctcctga cacaaaatta gaaccttcag aagatgatgg taaacctgag ttattagaag 9000
aaatggaagc ttctcccaca gaacttattg ctgtggaagg aactgagatt ctccaagatt 9060
tccaaaacaa aaccgatggt caagtttctg gagaagcaat caagatgttt cccaccatta 9120
aaacacctga ggctggaact gttattacaa ctgccgatga aattgaatta gaaggtgcta 9180
cacagtggcc acactctact tctgcttctg ccacctatgg ggtcgaggca ggtgtggtgc 9240
cttggctaag tccacagact tctgagaggc ccacgctttc ttcttctcca gaaataaacc 9300
ctgaaactca agcagcttta atcagagggc aggattccac gatagcagca tcagaacagc 9360
aagtggcagc gagaattctt gattccaatg atcaggcaac agtaaaccct gtggaattta 9420
atactgaggt tgcaacacca ccattttccc ttctggagac ttctaatgaa acagatttcc 9480
tgattggcat taatgaagag tcagtggaag gcacggcaat ctatttacca ggacctgatc 9540
gctgcaaaat gaacccgtgc cttaacggag gcacctgtta tcctactgaa acttcctacg 9600
tatgcacctg tgtgccagga tacagcggag accagtgtga acttgatttt gatgaatgtc 9660
actctaatcc ctgtcgtaat ggagccactt gtgttgatgg ttttaacaca ttcaggtgcc 9720
tctgccttcc aagttatgtt ggtgcacttt gtgagcaaga taccgagaca tgtgactatg 9780
gctggcacaa attccaaggg cagtgctaca aatactttgc ccatcgacgc acatgggatg 9840
cagctgaacg ggaatgccgt ctgcagggtg cccatctcac aagcatcctg tctcacgaag 9900
aacaaatgtt tgttaatcgt gtgggccatg attatcagtg gataggcctc aatgacaaga 9960
tgtttgagca tgacttccgt tggactgatg gcagcacact gcaatacgag aattggagac 10020
ccaaccagcc agacagcttc ttttctgctg gagaagactg tgttgtaatc atttggcatg 10080
agaatggcca gtggaatgat gttccctgca attaccatct cacctatacg tgcaagaaag 10140
gaacagttgc ttgcggccag ccccctgttg tagaaaatgc caagaccttt ggaaagatga 10200
aacctcgtta tgaaatcaac tccctgatta gataccactg caaagatggt ttcattcaac 10260
gtcaccttcc aactatccgg tgcttaggaa atggaagatg ggctatacct aaaattacct 10320
gcatgaaccc atctgcatac caaaggactt attctatgaa atactttaaa aattcctcat 10380
cagcaaagga caattcaata aatacatcca aacatgatca tcgttggagc cggaggtggc 10440
aggagtcgag gcgctgatcc ctaaaatggc gaacatgtgt tttcatcatt tcagccaaag 10500
tcctaacttc ctgtgccttt cctatcacct cgagaagtaa ttatcagttg gtttggattt 10560
ttggaccacc gttcagtcat tttgggttgc cgtgctccca aaacatttta aatgaaagta 10620
ttggcattca aaaagacagc agacaaaatg aaagaaaatg agagcagaaa gtaagcattt 10680
ccagcctatc taatttcttt agttttctat ttgcctccag tgcagtccat ttcctaatgt 10740
ataccagcct actgtactat ttaaaatgct caatttcagc accgatggcc atgtaaataa 10800
gatgatttaa tgttgatttt aatcctgtat ataaaataaa aagtcacaat gagtttgggc 10860
atatttaatg atgattatgg agccttagag gtctttaatc attggttcgg ctgcttttat 10920
gtagtttagg ctggaaatgg tttcacttgc tctttgactg tcagcaagac tgaagatggc 10980
ttttcctgga cagctagaaa acacaaaatc ttgtaggtca ttgcacctat ctcagccata 11040
ggtgcagttt gcttctacat gatgctaaag gctgcgaatg ggatcctgat ggaactaagg 11100
actccaatgt cgaactcttc tttgctgcat tcctttttct tcacttacaa gaaaggcctg 11160
aatggaggac ttttctgtaa ccagg 11185
<210>86
<211>2503
<212>DNA
<213>人类
<400>86
ggactttgaa atccaacccg gtcacctacc cgcgcgactg tgtccacgga tggcacgaaa 60
gccaagcgag tccccctgcc gagctactcg cgtccgcctc ctcccaagct gagctctgct 120
ccgcccacct gagtccttcg ccagttagga ggaaacacag ccgcttaatg aactgctgca 180
tcgggctggg agagaaagct cgcgggtccc accgggcctc ctacccaagt ctcagcgcgc 240
ttttcaccga ggcctcaatt ctgggatttg gcagctttgc tgtgaaagcc caatggacag 300
aggactgcag aaaatcaacc tatcctcctt caggaccaac gtacagaggt gcagttccat 360
ggtacaccat aaatcttgac ttaccaccct acaaaagatg gcatgaattg atgcttgaca 420
aggcaccaat gctaaaggtt atagtgaatt ctctgaagaa tatgataaat acattcgtgc 480
caagtggaaa agttatgcag gtggtggatg aaaaattgcc tggcctactt ggcaactttc 540
ctggcccttt tgaagaggaa atgaagggta ttgccgctgt tactgatata cctttaggag 600
agattatttc attcaatatt ttttatgaat tatttaccat ttgtacttca atagtagcag 660
aagacaaaaa aggtcatcta atacatggga gaaacatgga ttttggagta tttcttgggt 720
ggaacataaa taatgatacc tgggtcataa ctgagcaact aaaaccttta acagtgaatt 780
tggatttcca aagaaacaac aaaactgtct tcaaggcttc aagctttgct ggctatgtgg 840
gcatgttaac aggattcaaa ccaggactgt tcagtcttac actgaatgaa cgtttcagta 900
taaatggtgg ttatctgggt attctagaat ggattctggg aaagaaagat gccatgtgga 960
tagggttcct cactagaaca gttctggaaa atagcacaag ttatgaagaa gccaagaatt 1020
tattgaccaa gaccaagata ttggccccag cctactttat cctgggaggc aaccagtctg 1080
gggaaggttg tgtgattaca cgagacagaa aggaatcatt ggatgtatat gaactcgatg 1140
ctaagcaggg tagatggtat gtggtacaaa caaattatga ccgttggaaa catcccttct 1200
tccttgatga tcgcagaacg cctgcaaaga tgtgtctgaa ccgcaccagc caagagaata 1260
tctcatttga aaccatgtat gatgtcctgt caacaaaacc tgtcctcaac aagctgaccg 1320
tatacacaac cttgatagat gttaccaaag gtcaattcga aacttacctg cgggactgcc 1380
ctgacccttg tataggttgg tgagcacacg tctggcctac agaatgcggc ctctgagaca 1440
tgaagacacc atctccatgt gaccgaacac tgcagctgtc tgaccttcca aagactaaga 1500
ctcgcggcag gttctctttg agtcaaaagc ttgtcttcgt ccatctgttg acaaatgaca 1560
gacctttttt tttcccccat cagttgattt ttcttattta cagataactt ctttagggga 1620
agtaaaacag tcatctagaa ttcactgagt tttgtttcac tttgacattt ggggatctgg 1680
tgggcagtcg aaccatggtg aactccacct ccgtggaata aatggagatt cagcgtgggt 1740
gttgaatcca gcacgtctgt gtgagtaacg ggacagtaaa cactccacat tcttcagttt 1800
ttcacttcta cctacatatt tgtatgtttt tctgtataac agccttttcc ttctggttct 1860
aactgctgtt aaaattaata tatcattatc tttgctgtta ttgacagcga tataatttta 1920
ttacatatga ttagagggat gagacagaca ttcacctgta tatttctttt aatgggcaca 1980
aaatgggccc ttgcctctaa atagcacttt ttggggttca agaagtaatc agtatgcaaa 2040
gcaatctttt atacaataat tgaagtgttc cctttttcat aattactgta cttcccagta 2100
accctaagga agttgctaac ttaaaaaact gcatcccacg ttctgttaat ttagtaaata 2160
aacaagtcaa agacttgtgg aaaataggaa gtgaacccat attttaaatt ctcataagta 2220
gcattcatgt aataaacagg tttttagttt gttcttcaga ttgataggga gttttaaaga 2280
aattttagta gttactaaaa ttatgttact gtatttttca gaaatcaaac tgcttatgaa 2340
aagtactaat agaacttgtt aacctttcta accttcacga ttaactgtga aatgtacgtc 2400
atttgtgcaa gaccgtttgt ccacttcatt ttgtataatc acagttgtgt tcctgacact 2460
caataaacag tcattggaaa gagtgccagt cagcagtcat gca 2503
<210>87
<211>2341
<212>DNA
<213>人类
<400>87
ggctcttctt tgcctctgct ggagtccggg gagtggcgtt ggctgctaga gcgatgccgg 60
gccggagttg cgtcgcctta gtcctcctgg ctgccgccgt cagctgtgcc gtcgcgcagc 120
acgcgccgcc gtggacagag gactgcagaa aatcaaccta tcctccttca ggaccaacgt 180
acagaggtgc agttccatgg tacaccataa atcttgactt accaccctac aaaagatggc 240
atgaattgat gcttgacaag gcaccaatgc taaaggttat agtgaattct ctgaagaata 300
tgataaatac attcgtgcca agtggaaaag ttatgcaggt ggtggatgaa aaattgcctg 360
gcctacttgg caactttcct ggcccttttg aagaggaaat gaagggtatt gccgctgtta 420
ctgatatacc tttaggagag attatttcat tcaatatttt ttatgaatta tttaccattt 480
gtacttcaat agtagcagaa gacaaaaaag gtcatctaat acatgggaga aacatggatt 540
ttggagtatt tcttgggtgg aacataaata atgatacctg ggtcataact gagcaactaa 600
aacctttaac agtgaatttg gatttccaaa gaaacaacaa aactgtcttc aaggcttcaa 660
gctttgctgg ctatgtgggc atgttaacag gattcaaacc aggactgttc agtcttacac 720
tgaatgaacg tttcagtata aatggtggtt atctgggtat tctagaatgg attctgggaa 780
agaaagatgc catgtggata gggttcctca ctagaacagt tctggaaaat agcacaagtt 840
atgaagaagc caagaattta ttgaccaaga ccaagatatt ggccccagcc tactttatcc 900
tgggaggcaa ccagtctggg gaaggttgtg tgattacacg agacagaaag gaatcattgg 960
atgtatatga actcgatgct aagcagggta gatggtatgt ggtacaaaca aattatgacc 1020
gttggaaaca tcccttcttc cttgatgatc gcagaacgcc tgcaaagatg tgtctgaacc 1080
gcaccagcca agagaatatc tcatttgaaa ccatgtatga tgtcctgtca acaaaacctg 1140
tcctcaacaa gctgaccgta tacacaacct tgatagatgt taccaaaggt caattcgaaa 1200
cttacctgcg ggactgccct gacccttgta taggttggtg agcacacgtc tggcctacag 1260
aatgcggcct ctgagacatg aagacaccat ctccatgtga ccgaacactg cagctgtctg 1320
accttccaaa gactaagact cgcggcaggt tctctttgag tcaaaagctt gtcttcgtcc 1380
atctgttgac aaatgacaga cctttttttt tcccccatca gttgattttt cttatttaca 1440
gataacttct ttaggggaag taaaacagtc atctagaatt cactgagttt tgtttcactt 1500
tgacatttgg ggatctggtg ggcagtcgaa ccatggtgaa ctccacctcc gtggaataaa 1560
tggagattca gcgtgggtgt tgaatccagc acgtctgtgt gagtaacggg acagtaaaca 1620
ctccacattc ttcagttttt cacttctacc tacatatttg tatgtttttc tgtataacag 1680
ccttttcctt ctggttctaa ctgctgttaa aattaatata tcattatctt tgctgttatt 1740
gacagcgata taattttatt acatatgatt agagggatga gacagacatt cacctgtata 1800
tttcttttaa tgggcacaaa atgggccctt gcctctaaat agcacttttt ggggttcaag 1860
aagtaatcag tatgcaaagc aatcttttat acaataattg aagtgttccc tttttcataa 1920
ttactgtact tcccagtaac cctaaggaag ttgctaactt aaaaaactgc atcccacgtt 1980
ctgttaattt agtaaataaa caagtcaaag acttgtggaa aataggaagt gaacccatat 2040
tttaaattct cataagtagc attcatgtaa taaacaggtt tttagtttgt tcttcagatt 2100
gatagggagt tttaaagaaa ttttagtagt tactaaaatt atgttactgt atttttcaga 2160
aatcaaactg cttatgaaaa gtactaatag aacttgttaa cctttctaac cttcacgatt 2220
aactgtgaaa tgtacgtcat ttgtgcaaga ccgtttgtcc acttcatttt gtataatcac 2280
agttgtgttc ctgacactca ataaacagtc attggaaaga gtgccagtca gcagtcatgc 2340
a 2341
<210>88
<211>2039
<212>DNA
<213>人类
<400>88
ccggccctcg ccctgtccgc cgccaccgcc gccgccgcca gagtcgccat gcagatcccg 60
cgcgccgctc ttctcccgct gctgctgctg ctgctggcgg cgcccgcctc ggcgcagctg 120
tcccgggccg gccgctcggc gcctttggcc gccgggtgcc cagaccgctg cgagccggcg 180
cgctgcccgc cgcagccgga gcactgcgag ggcggccggg cccgggacgc gtgcggctgc 240
tgcgaggtgt gcggcgcgcc cgagggcgcc gcgtgcggcc tgcaggaggg cccgtgcggc 300
gaggggctgc agtgcgtggt gcccttcggg gtgccagcct cggccacggt gcggcggcgc 360
gcgcaggccg gcctctgtgt gtgcgccagc agcgagccgg tgtgcggcag cgacgccaac 420
acctacgcca acctgtgcca gctgcgcgcc gccagccgcc gctccgagag gctgcaccgg 480
ccgccggtca tcgtcctgca gcgcggagcc tgcggccaag ggcaggaaga tcccaacagt 540
ttgcgccata aatataactt tatcgcggac gtggtggaga agatcgcccc tgccgtggtt 600
catatcgaat tgtttcgcaa gcttccgttt tctaaacgag aggtgccggt ggctagtggg 660
tctgggttta ttgtgtcgga agatggactg atcgtgacaa atgcccacgt ggtgaccaac 720
aagcaccggg tcaaagttga gctgaagaac ggtgccactt acgaagccaa aatcaaggat 780
gtggatgaga aagcagacat cgcactcatc aaaattgacc accagggcaa gctgcctgtc 840
ctgctgcttg gccgctcctc agagctgcgg ccgggagagt tcgtggtcgc catcggaagc 900
ccgttttccc ttcaaaacac agtcaccacc gggatcgtga gcaccaccca gcgaggcggc 960
aaagagctgg ggctccgcaa ctcagacatg gactacatcc agaccgacgc catcatcaac 1020
tatggaaact cgggaggccc gttagtaaac ctggacggtg aagtgattgg aattaacact 1080
ttgaaagtga cagctggaat ctcctttgca atcccatctg ataagattaa aaagttcctc 1140
acggagtccc atgaccgaca ggccaaagga aaagccatca ccaagaagaa gtatattggt 1200
atccgaatga tgtcactcac gtccagcaaa gccaaagagc tgaaggaccg gcaccgggac 1260
ttcccagacg tgatctcagg agcgtatata attgaagtaa ttcctgatac cccagcagaa 1320
gctggtggtc tcaaggaaaa cgacgtcata atcagcatca atggacagtc cgtggtctcc 1380
gccaatgatg tcagcgacgt cattaaaagg gaaagcaccc tgaacatggt ggtccgcagg 1440
ggtaatgaag atatcatgat cacagtgatt cccgaagaaa ttgacccata ggcagaggca 1500
tgagctggac ttcatgtttc cctcaaagac tctcccgtgg atgacggatg aggactctgg 1560
gctgctggaa taggacactc aagacttttg actgccattt tgtttgttca gtggagactc 1620
cctggccaac agaatccttc ttgatagttt gcaggcaaaa caaatgtaat gttgcagatc 1680
cgcaggcaga agctctgccc ttctgtatcc tatgtatgca gtgtgctttt tcttgccagc 1740
ttgggccatt cttgcttaga cagtcagcat ttgtctcctc ctttaactga gtcatcatct 1800
tagtccaact aatgcagtcg atacaatgcg tagatagaag aagccccacg ggagccagga 1860
tgggactggt cgtgtttgtg cttttctcca agtcagcacc caaaggtcaa tgcacagaga 1920
ccccgggtgg gtgagcgctg gcttctcaaa cggccgaagt tgcctctttt aggaatctct 1980
ttggaattgg gagcacgatg actctgagtt tgagctatta aagtacttct tacacattg 2039
<210>89
<211>1387
<212>DNA
<213>人类
<400>89
ccgggtcgga gccccccgga gctgcgcgcg ggcttgcagc gcctcgcccg cgctgtcctc 60
ccggtgtccc gcttctccgc gccccagccg ccggctgcca gcttttcggg gccccgagtc 120
gcacccagcg aagagagcgg gcccgggaca agctcgaact ccggccgcct cgcccttccc 180
cggctccgct ccctctgccc cctcggggtc gcgcgcccac gatgctgcag ggccctggct 240
cgctgctgct gctcttcctc gcctcgcact gctgcctggg ctcggcgcgc gggctcttcc 300
tctttggcca gcccgacttc tcctacaagc gcagcaattg caagcccatc cctgccaacc 360
tgcagctgtg ccacggcatc gaataccaga acatgcggct gcccaacctg ctgggccacg 420
agaccatgaa ggaggtgctg gagcaggccg gcgcttggat cccgctggtc atgaagcagt 480
gccacccgga caccaagaag ttcctgtgct cgctcttcgc ccccgtctgc ctcgatgacc 540
tagacgagac catccagcca tgccactcgc tctgcgtgca ggtgaaggac cgctgcgccc 600
cggtcatgtc cgccttcggc ttcccctggc ccgacatgct tgagtgcgac cgtttccccc 660
aggacaacga cctttgcatc cccctcgcta gcagcgacca cctcctgcca gccaccgagg 720
aagctccaaa ggtatgtgaa gcctgcaaaa ataaaaatga tgatgacaac gacataatgg 780
aaacgctttg taaaaatgat tttgcactga aaataaaagt gaaggagata acctacatca 840
accgagatac caaaatcatc ctggagacca agagcaagac catttacaag ctgaacggtg 900
tgtccgaaag ggacctgaag aaatcggtgc tgtggctcaa agacagcttg cagtgcacct 960
gtgaggagat gaacgacatc aacgcgccct atctggtcat gggacagaaa cagggtgggg 1020
agctggtgat cacctcggtg aagcggtggc agaaggggca gagagagttc aagcgcatct 1080
cccgcagcat ccgcaagctg cagtgctagt cccggcatcc tgatggctcc gacaggcctg 1140
ctccagagca cggctgacca tttctgctcc gggatctcag ctcccgttcc ccaagcacac 1200
tcctagctgc tccagtctca gcctgggcag cttccccctg ccttttgcac gtttgcatcc 1260
ccagcatttc ctgagttata aggccacagg agtggatagc tgttttcacc taaaggaaaa 1320
gcccacccga atcttgtaga aatattcaaa ctaataaaat catgaatatt tttatgaagt 1380
ttaaaaa 1387
<210>90
<211>1092
<212>DNA
<213>人类
<400>90
tgtccctgga attctgggac actggctggg gtttgaggag agaagccagt acctacctgg 60
ctgcaggatg aagctggcca gtggcttctt ggttttgtgg ctcagccttg ggggtggcct 120
ggctcagagc gacacgagcc ctgacacgga ggagtcctat tcagactggg gccttcggca 180
cctccgggga agctttgaat ccgtcaatag ctacttcgat tcttttctgg agctgctggg 240
agggaagaat ggagtctgtc agtacaggtg ccgatatgga aaggcaccaa tgcccagacc 300
tggctacaag ccccaagagc ccaatggctg cggctcctat ttcctgggtc tcaaggtacc 360
agaaagtatg gacttgggca ttccagcaat gacaaagtgc tgcaaccagc tggatgtctg 420
ttatgacact tgcggtgcca acaaatatcg ctgtgatgca aaattccgat ggtgtctcca 480
ctcgatctgc tctgacctta agcggagtct gggctttgtc tccaaagtgg aagcagcctg 540
tgattccctg gttgacactg tgttcaacac cgtgtggacc ttgggctgcc gcccctttat 600
gaatagtcag cgggcagctt gcatctgtgc agaggaggag aaggaagagt tatgaggaag 660
aagtgattcc ttcctggttt tgagtgacac cacagctgtc agccttcaag atgtcaagtc 720
ttcgagtcag cgtgactcat tcattcttcc aacagtttgg acaccacaaa gcaggagaaa 780
gggaacattt ttctacagct ggaaagtgag tcctatcctt tgaggaaatt tgaaaaaaga 840
catggagtgg tttgaaagct actcttcatt taagactgct ctccccaacc aagacacatt 900
tgcctggaaa ttcagttctt agcttaaaga ctaaaatgca agcaaaccct gcaattcctg 960
gacctgatag ttatattcat gagtgaaatt gtggggagtc cagccatttg ggaggcaatg 1020
actttctgct ggcccatgtt tcagttgcca gtaagcttct cacatttaat aaagtgtact 1080
ttttagaaca tt 1092
<210>91
<211>1807
<212>DNA
<213>人类
<400>91
gcacgaggga agagggtgat ccgacccggg gaaggtcgct gggcagggcg agttgggaaa 60
gcggcagccc ccgccgcccc cgcagcccct tctcctcctt tctcccacgt cctatctgcc 120
tctcgctgga ggccaggccg tgcagcatcg aagacaggag gaactggagc ctcattggcc 180
ggcccggggc gccggcctcg ggcttaaata ggagctccgg gctctggctg ggacccgacc 240
gctgccggcc gcgctcccgc tgctcctgcc gggtgatgga aaaccccagc ccggccgccg 300
ccctgggcaa ggccctctgc gctctcctcc tggccactct cggcgccgcc ggccagcctc 360
ttgggggaga gtccatctgt tccgccagag ccccggccaa atacagcatc accttcacgg 420
gcaagtggag ccagacggcc ttccccaagc agtaccccct gttccgcccc cctgcgcagt 480
ggtcttcgct gctgggggcc gcgcatagct ccgactacag catgtggagg aagaaccagt 540
acgtcagtaa cgggctgcgc gactttgcgg agcgcggcga ggcctgggcg ctgatgaagg 600
agatcgaggc ggcgggggag gcgctgcaga gcgtgcacgc ggtgttttcg gcgcccgccg 660
tccccagcgg caccgggcag acgtcggcgg agctggaggt gcagcgcagg cactcgctgg 720
tctcgtttgt ggtgcgcatc gtgcccagcc ccgactggtt cgtgggcgtg gacagcctgg 780
acctgtgcga cggggaccgt tggcgggaac aggcggcgct ggacctgtac ccctacgacg 840
ccgggacgga cagcggcttc accttctcct cccccaactt cgccaccatc ccgcaggaca 900
cggtgaccga gataacgtcc tcctctccca gccacccggc caactccttc tactacccgc 960
ggctgaaggc cctgcctccc atcgccaggg tgacactggt gcggctgcga cagagcccca 1020
gggccttcat ccctcccgcc ccagtcctgc ccagcaggga caatgagatt gtagacagcg 1080
cctcagttcc agaaacgccg ctggactgcg aggtctccct gtggtcgtcc tggggactgt 1140
gcggaggcca ctgtgggagg ctcgggacca agagcaggac tcgctacgtc cgggtccagc 1200
ccgccaacaa cgggagcccc tgccccgagc tcgaagaaga ggctgagtgc gtccctgata 1260
actgcgtcta agaccagagc cccgcagccc ctggggcccc cggagccatg gggtgtcggg 1320
ggctcctgtg caggctcatg ctgcaggcgg ccgaggcaca gggggtttcg cgctgctcct 1380
gaccgcggtg aggccgcgcc gaccatctct gcactgaagg gccctctggt ggccggcacg 1440
ggcattggga aacagcctcc tcctttccca accttgcttc ttaggggccc ccgtgtcccg 1500
tctgctctca gcctcctcct cctgcaggat aaagtcatcc ccaaggctcc agctactcta 1560
aattatggtc tccttataag ttattgctgc tccaggagat tgtccttcat cgtccagggg 1620
cctggctccc acgtggttgc agatacctca gacctggtgc tctaggctgt gctgagccca 1680
ctctcccgag ggcgcatcca agcgggggcc acttgagaag tgaataaatg gggcggtttc 1740
ggaagcgtca gtgtttccat gttatggatc tctctgcgtt tgaataaaga ctatctctgt 1800
tgctcac 1807
<210>92
<211>1077
<212>DNA
<213>人类
<400>92
cccgcccccg ccccttccga gcaaactttt ggcacccacc gcagcccagc gcgcgttcgt 60
gctccgcagg gcgcgcctct ctccgccaat gccaggcgcg cgggggagcc attaggaggc 120
gaggagagag gagggcgcag ctcccgccca gcccagccct gcccagccct gcccggaggc 180
agacgcgccg gaaccgggac gcgataaata tgcagagcgg aggcttcgcg cagcagagcc 240
cgcgcgccgc ccgctccggg tgctgaatcc aggcgtgggg acacgagcca ggcgccgccg 300
ccggagccag cggagccggg gccagagccg gagcgcgtcc gcgtccacgc agccgccggc 360
cggccagcac ccagggccct gcatgccagg tcgttggagg tggcagcgag acatgcaccc 420
ggcccggaag ctcctcagcc tcctcttcct catcctgatg ggcactgaac tcactcaaaa 480
taaaagagaa aacaaagcag agaagatggg agggccagag agcgagagga agaccacagg 540
agagaagaca ctgaacgagc ttcccttgtt ttgcctggaa gcccacgctg gctccctggc 600
tctgcccagg atgtgcagtc caaatcccaa tccagcagtg gggttatgtc gtcccgctta 660
ccctcagagc ccttctcctg gtgctgccca gacgatcagc cagtccctcc tggagaggtt 720
ctgcatggcc tctaggagag aagttttctt ggccccagga aggcctggtg gagggtggtg 780
gttgtgcact gttgctggac agatgcattc attcatgtgc acacacacac acacacatgc 840
acacacaggg gagcagatac ctgcagagaa gagccaacca ggtcctgatt agtggcaagc 900
tgccccacaa agggctatgc ctgtgtctta ttgagacacc ttggcaaaga gatggctgat 960
tctgggtggt cctggacatg gccgcaccca agggccctcc aagccttaat ggcaccctga 1020
agcctccatg cccaggccaa aagatgcttt tcctccctaa aaaaaaaaaa aaaaaaa 1077
<210>93
<211>4229
<212>DNA
<213>人类
<400>93
ggggccccag tggccgccgc ggagcgaggt tgcctggaga gagcgcctgg gcgcagaagg 60
gttaacgggc caccgggggc tcgcagagca ggagggtgct ctcggacggt gtgtccccca 120
ctgcactcct gaacttggag gacagggtcg ccgcgaggga cgcagagagc accctccacg 180
cccagatgcc tgcgtagttt ttgtgaccag tccgctcctg cctccccctg gggcagtaga 240
gggggagcga tggagaactg gactggcagg ccctggctgt atctgctgct gcttctgtcc 300
ctccctcagc tctgcttgga tcaggaggtg ttgtccggac actctcttca gacacctaca 360
gaggagggcc agggccccga aggtgtctgg ggaccttggg tccagtgggc ctcttgctcc 420
cagccctgcg gggtgggggt gcagcgcagg agccggacat gtcagctccc tacagtgcag 480
ctccacccga gtctgcccct ccctccccgg cccccaagac atccagaagc cctcctcccc 540
cggggccagg gtcccagacc ccagacttct ccagaaaccc tccccttgta caggacacag 600
tctcggggaa ggggtggccc acttcgaggt cccgcttccc acctagggag agaggagacc 660
caggagattc gagcggccag gaggtcccgg cttcgagacc ccatcaagcc aggaatgttc 720
ggttatggga gagtgccctt tgcattgcca ctgcaccgga accgcaggca ccctcggagc 780
ccacccagat ctgagctgtc cctgatctct tctagagggg aagaggctat tccgtcccct 840
actccaagag cagagccatt ctccgcaaac ggcagccccc aaactgagct ccctcccaca 900
gaactgtctg tccacacccc atccccccaa gcagaacctc taagccctga aactgctcag 960
acagaggtgg cccccagaac caggcctgcc cccctacggc atcaccccag agcccaggcc 1020
tctggcacag agcccccctc acccacgcac tccttaggag aaggtggctt cttccgtgca 1080
tcccctcagc cacgaaggcc aagttcccag ggttgggcca gtccccaggt agcagggaga 1140
cgccctgatc cttttccttc ggtccctcgg ggccgaggcc agcagggcca agggccttgg 1200
ggaacggggg ggactcctca cgggccccgc ctggagcctg accctcagca cccgggcgcc 1260
tggctgcccc tgctgagcaa cggcccccat gccagctccc tctggagcct ctttgctccc 1320
agtagcccta ttccaagatg ttctggggag agtgaacagc taagagcctg cagccaagcg 1380
ccctgccccc ctgagcagcc agacccccgg gccctgcagt gcgcagcctt taactcccag 1440
gaattcatgg gccagctgta tcagtgggag cccttcactg aagtccaggg ctcccagcgc 1500
tgtgaactga actgccggcc ccgtggcttc cgcttctatg tccgtcacac tgaaaaggtc 1560
caggatggga ccctgtgtca gcctggagcc cctgacatct gtgtggctgg acgctgtctg 1620
agccccggct gtgatgggat ccttggctct ggcaggcgtc ctgatggctg tggagtctgt 1680
gggggtgatg attctacctg tcgccttgtt tcggggaacc tcactgaccg agggggcccc 1740
ctgggctatc agaagatctt gtggattcca gcgggagcct tgcggctcca gattgcccag 1800
ctccggccta gctccaacta cctggcactt cgtggccctg ggggccggtc catcatcaat 1860
gggaactggg ctgtggatcc ccctgggtcc tacagggccg gcgggaccgt ctttcgatat 1920
aaccgtcctc ccagggagga gggcaaaggg gagagtctgt cggctgaagg ccccaccacc 1980
cagcctgtgg atgtctatat gatctttcag gaggaaaacc caggcgtttt ttatcagtat 2040
gtcatctctt cacctcctcc aatccttgag aaccccaccc cagagccccc tgtcccccag 2100
cttcagccgg agattctgag ggtggagccc ccacttgctc cggcaccccg cccagcccgg 2160
accccaggca ccctccagcg tcaggtgcgg atcccccaga tgcccgcccc gccccatccc 2220
aggacacccc tggggtctcc agctgcgtac tggaaacgag tgggacactc tgcatgctca 2280
gcgtcctgcg ggaaaggtgt ctggcgcccc attttcctct gcatctcccg tgagtcggga 2340
gaggaactgg atgaacgcag ctgtgccgcg ggtgccaggc ccccagcctc ccctgaaccc 2400
tgccacggca ccccatgccc cccatactgg gaggctggcg agtggacatc ctgcagccgc 2460
tcctgtggcc ccggcaccca gcaccgccag ctgcagtgcc ggcaggaatt tggggggggt 2520
ggctcctcgg tgcccccgga gcgctgtgga catctccccc ggcccaacat cacccagtct 2580
tgccagctgc gcctctgtgg ccattgggaa gttggctctc cttggagcca gtgctccgtg 2640
cggtgcggcc ggggccagag aagccggcag gttcgctgtg ttgggaacaa cggtgatgaa 2700
gtgagcgagc aggagtgtgc gtcaggcccc ccgcagcccc ccagcagaga ggcctgtgac 2760
atggggccct gtactactgc ctggttccac agcgactgga gctccaagtg ctcagccgag 2820
tgtgggacgg gaatccagcg gcgctctgtg gtctgccttg ggagtggggc agccctcggg 2880
ccaggccagg gggaagcagg agcaggaact gggcagagct gtccaacagg aagccggccc 2940
cctgacatgc gcgcctgcag cctggggccc tgtgagagaa cttggcgctg gtacacaggg 3000
ccctggggtg agtgctcctc cgaatgtggc tctggcacac agcgtagaga catcatctgt 3060
gtatccaaac tggggacgga gttcaacgtg acttctccga gcaactgttc tcacctcccc 3120
aggccccctg ccctgcagcc ctgtcaaggg caggcctgcc aggaccgatg gttttccacg 3180
ccctggagcc catgttctcg ctcctgccaa gggggaacgc agacacggga ggtccagtgc 3240
ctgagcacca accagaccct cagcacccga tgccctcctc aactgcggcc ctccaggaag 3300
cgcccctgta acagccaacc ctgcagccag cgccctgatg atcaatgcaa ggacagctct 3360
ccacattgcc ccctggtggt acaggcccgg ctctgcgtct acccctacta cacagccacc 3420
tgttgccgct cttgcgcaca tgtcctggag cggtctcccc aggatccctc ctgaaagggg 3480
tccggggcac cttcacggtt ttctgtgcca ccatcggtca cccattgatc ggcccactct 3540
gaaccccctg gctctccagc ctgtcccagt ctcagcaggg atgtcctcca ggtgacagag 3600
ggtggcaagg tgactgacac aaagtgactt tcagggctgt ggtcaggccc atgtggtggt 3660
gtgatgggtg tgtgcacata tgcctcaggt gtgcttttgg gactgcatgg atatgtgtgt 3720
gctcaaacgt gtatcacttt tcaaaaagag gttacacaga ctgagaagga caagacctgt 3780
ttccttgaga ctttcctagg tggaaaggaa agcaagtctg cagttccttg ctaatctgag 3840
ctacttagag tgtggtctcc ccaccaactc cagttttgtg ccctaagcct catttctcat 3900
gttcagacct cacatcttct aagccgccct gtgtctctga ccccttctca tttgcctagt 3960
atctctgccc ctgcctccct aattagctag ggctggggtc agccactgcc aatcctgcct 4020
tactcaggaa ggcaggagga aagagactgc ctctccagag caaggcccag ctgggcagag 4080
ggtgaaaaag agaaatgtga gcatccgctc ccccaccacc ccgcccagcc cctagcccca 4140
ctccctgcct cctgaaatgg ttcccaccca gaactaattt attttttatt aaagatggtc 4200
atgacaaatg aaaaaaaaaa aaaaaaaaa 4229
<210>94
<211>5826
<212>DNA
<213>人类
<400>94
gaggaggaga cggcatccag tacagagggg ctggacttgg acccctgcag cagccctgca 60
caggagaagc ggcatataaa gccgcgctgc ccgggagccg ctcggccacg tccaccggag 120
catcctgcac tgcagggccg gtctctcgct ccagcagagc ctgcgccttt ctgactcggt 180
ccggaacact gaaaccagtc atcactgcat ctttttggca aaccaggagc tcagctgcag 240
gaggcaggat ggtctggagg ctggtcctgc tggctctgtg ggtgtggccc agcacgcaag 300
ctggtcacca ggacaaagac acgaccttcg accttttcag tatcagcaac atcaaccgca 360
agaccattgg cgccaagcag ttccgcgggc ccgaccccgg cgtgccggct taccgcttcg 420
tgcgctttga ctacatccca ccggtgaacg cagatgacct cagcaagatc accaagatca 480
tgcggcagaa ggagggcttc ttcctcacgg cccagctcaa gcaggacggc aagtccaggg 540
gcacgctgtt ggctctggag ggccccggtc tctcccagag gcagttcgag atcgtctcca 600
acggccccgc ggacacgctg gatctcacct actggattga cggcacccgg catgtggtct 660
ccctggagga cgtcggcctg gctgactcgc agtggaagaa cgtcaccgtg caggtggctg 720
gcgagaccta cagcttgcac gtgggctgcg acctcataga cagcttcgct ctggacgagc 780
ccttctacga gcacctgcag gcggaaaaga gccggatgta cgtggccaaa ggctctgcca 840
gagagagtca cttcaggggt ttgcttcaga acgtccacct agtgtttgaa aactctgtgg 900
aagatattct aagcaagaag ggttgccagc aaggccaggg agctgagatc aacgccatca 960
gtgagaacac agagacgctg cgcctgggtc cgcatgtcac caccgagtac gtgggcccca 1020
gctcggagag gaggcccgag gtgtgcgaac gctcgtgcga ggagctggga aacatggtcc 1080
aggagctctc ggggctccac gtcctcgtga accagctcag cgagaacctc aagagagtgt 1140
cgaatgataa ccagtttctc tgggagctca ttggtggccc tcctaagaca aggaacatgt 1200
cagcttgctg gcaggatggc cggttctttg cggaaaatga aacgtgggtg gtggacagct 1260
gcaccacgtg tacctgcaag aaatttaaaa ccatttgcca ccaaatcacc tgcccgcctg 1320
caacctgcgc cagtccatcc tttgtggaag gcgaatgctg cccttcctgc ctccactcgg 1380
tggacggtga ggagggctgg tctccgtggg cagagtggac ccagtgctcc gtgacgtgtg 1440
gctctgggac ccagcagaga ggccggtcct gtgacgtcac cagcaacacc tgcttggggc 1500
cctccatcca gacacgggct tgcagtctga gcaagtgtga cacccgcatc cggcaggacg 1560
gcggctggag ccactggtca ccttggtctt catgctctgt gacctgtgga gttggcaata 1620
tcacacgcat ccgtctctgc aactccccag tgccccagat ggggggcaag aattgcaaag 1680
ggagtggccg ggagaccaaa gcctgccagg gcgccccatg cccaatcgat ggccgctgga 1740
gcccctggtc cccgtggtcg gcctgcactg tcacctgtgc cggtgggatc cgggagcgca 1800
cccgggtctg caacagccct gagcctcagt acggagggaa ggcctgcgtg ggggatgtgc 1860
aggagcgtca gatgtgcaac aagaggagct gccccgtgga tggctgttta tccaacccct 1920
gcttcccggg agcccagtgc agcagcttcc ccgatgggtc ctggtcatgc ggctcctgcc 1980
ctgtgggctt cttgggcaat ggcacccact gtgaggacct ggacgagtgt gccctggtcc 2040
ccgacatctg cttctccacc agcaaggtgc ctcgctgtgt caacactcag cctggcttcc 2100
actgcctgcc ctgcccgccc cgatacagag ggaaccagcc cgtcggggtc ggcctggaag 2160
cagccaagac ggaaaagcaa gtgtgtgagc ccgaaaaccc atgcaaggac aagacacaca 2220
actgccacaa gcacgcggag tgcatctacc tgggccactt cagcgacccc atgtacaagt 2280
gcgagtgcca gacaggctac gcgggcgacg ggctcatctg cggggaggac tcggacctgg 2340
acggctggcc caacctcaat ctggtctgcg ccaccaacgc cacctaccac tgcatcaagg 2400
ataactgccc ccatctgcca aattctgggc aggaagactt tgacaaggac gggattggcg 2460
atgcctgtga tgatgacgat gacaatgacg gtgtgaccga tgagaaggac aactgccagc 2520
tcctcttcaa tccccgccag gctgactatg acaaggatga ggttggggac cgctgtgaca 2580
actgccctta cgtgcacaac cctgcccaga tcgacacaga caacaatgga gagggtgacg 2640
cctgctccgt ggacattgat ggggacgatg tcttcaatga acgagacaat tgtccctacg 2700
tctacaacac tgaccagagg gacacggatg gtgacggtgt gggggatcac tgtgacaact 2760
gccccctggt gcacaaccct gaccagaccg acgtggacaa tgaccttgtt ggggaccagt 2820
gtgacaacaa cgaggacata gatgacgacg gccaccagaa caaccaggac aactgcccct 2880
acatctccaa cgccaaccag gctgaccatg acagagacgg ccagggcgac gcctgtgacc 2940
ctgatgatga caacgatggc gtccccgatg acagggacaa ctgccggctt gtgttcaacc 3000
cagaccagga ggacttggac ggtgatggac ggggtgatat ttgtaaagat gattttgaca 3060
atgacaacat cccagatatt gatgatgtgt gtcctgaaaa caatgccatc agtgagacag 3120
acttcaggaa cttccagatg gtccccttgg atcccaaagg gaccacccaa attgatccca 3180
actgggtcat tcgccatcaa ggcaaggagc tggttcagac agccaactcg gaccccggca 3240
tcgctgtagg ttttgacgag tttgggtctg tggacttcag tggcacattc tacgtaaaca 3300
ctgaccggga cgacgactat gccggcttcg tctttggtta ccagtcaagc agccgcttct 3360
atgtggtgat gtggaagcag gtgacgcaga cctactggga ggaccagccc acgcgggcct 3420
atggctactc cggcgtgtcc ctcaaggtgg tgaactccac cacggggacg ggcgagcacc 3480
tgaggaacgc gctgtggcac acggggaaca cgccggggca ggtgcgaacc ttatggcacg 3540
accccaggaa cattggctgg aaggactaca cggcctatag gtggcacctg actcacaggc 3600
ccaagactgg ctacatcaga gtcttagtgc atgaaggaaa acaggtcatg gcagactcag 3660
gacctatcta tgaccaaacc tacgctggcg ggcggctggg tctatttgtc ttctctcaag 3720
aaatggtcta tttctcagac ctcaagtacg aatgcagaga tatttaaaca agatttgctg 3780
catttccggc aatgccctgt gcatgccatg gtccctagac acctcagttc attgtggtcc 3840
ttgtggcttc tctctctagc agcacctcct gtcccttgac cttaactctg atggttcttc 3900
acctcctgcc agcaacccca aacccaagtg ccttcagagg ataaatatca atggaactca 3960
gagatgaaca tctaacccac tagaggaaac cagtttggtg atatatgaga ctttatgtgg 4020
agtgaaaatt gggcatgcca ttacattgct ttttcttgtt tgtttaaaaa gaatgacgtt 4080
tacatataaa atgtaattac ttattgtatt tatgtgtata tggagttgaa gggaatactg 4140
tgcataagcc attatgataa attaagcatg aaaaatattg ctgaactact tttggtgctt 4200
aaagttgtca ctattcttga attagagttg ctctacaatg acacacaaat cccattaaat 4260
aaattataaa caagggtcaa ttcaaatttg aagtaatgtt ttagtaagga gagattagaa 4320
gacaacaggc atagcaaatg acataagcta ccgattaact aatcggaaca tgtaaaacag 4380
ttacaaaaat aaacgaactc tcctcttgtc ctacaatgaa agccctcatg tgcagtagag 4440
atgcagtttc atcaaagaac aaacatcctt gcaaatgggt gtgacgcggt tccagatgtg 4500
gatttggcaa aacctcattt aagtaaaagg ttagcagagc aaagtgcggt gctttagctg 4560
ctgcttgtgc cgctgtggcg tcggggaggc tcctgcctga gcttccttcc ccagctttgc 4620
tgcctgagag gaaccagagc agacgcacag gccggaaaag gcgcatctaa cgcgtatcta 4680
ggctttggta actgcggaca agttgctttt acctgatttg atgatacatt tcattaaggt 4740
tccagttata aatattttgt taatatttat taagtgacta tagaatgcaa ctccatttac 4800
cagtaactta ttttaaatat gcctagtaac acatatgtag tataatttct agaaacaaac 4860
atctaataag tatataatcc tgtgaaaata tgaggcttga taatattagg ttgtcacgat 4920
gaagcatgct agaagctgta acagaataca tagagaataa tgaggagttt atgatggaac 4980
cttaaatata taatgttgcc agcgatttta gttcaatatt tgttactgtt atctatctgc 5040
tgtatatgga attcttttaa ttcaaacgct gaaaagaatc agcatttagt cttgccaggc 5100
acacccaata atcagtcatg tgtaatatgc acaagtttgt ttttgttttt gttttttttg 5160
ttggttggtt tgtttttttg ctttaagttg catgatcttt ctgcaggaaa tagtcactca 5220
tcccactcca cataaggggt ttagtaagag aagtctgtct gtctgatgat ggataggggg 5280
caaatctttt tcccctttct gttaatagtc atcacatttc tatgccaaac aggaacaatc 5340
cataacttta gtcttaatgt acacattgca ttttgataaa attaattttg ttgtttcctt 5400
tgaggttgat cgttgtgttg ttgttttgct gcacttttta cttttttgcg tgtggagctg 5460
tattcccgag accaacgaag cgttgggata cttcattaaa tgtagcgact gtcaacagcg 5520
tgcaggtttt ctgtttctgt gttgtggggt caaccgtaca atggtgtggg agtgacgatg 5580
atgtgaatat ttagaatgta ccatattttt tgtaaattat ttatgttttt ctaaacaaat 5640
ttatcgtata ggttgatgaa acgtcatgtg ttttgccaaa gactgtaaat atttatttat 5700
gtgttcacat ggtcaaaatt tcaccactga aaccctgcac ttagctagaa cctcattttt 5760
aaagattaac aacaggaaat aaattgtaaa aaaggttttc tatacatgaa aaaaaaaaaa 5820
aaaaaa 5826
<210>95
<211>9645
<212>DNA
<213>人类
<400>95
atgcccaagc gcgcgcactg gggggccctc tccgtggtgc tgatcctgct ttggggccat 60
ccgcgagtgg cgctggcctg cccgcatcct tgtgcctgct acgtccccag cgaggtccac 120
tgcacgttcc gatccctggc ttccgtgccc gctggcattg ctagacacgt ggaaagaatc 180
aatttggggt ttaatagcat acaggccctg tcagaaacct catttgcagg actgaccaag 240
ttggagctac ttatgattca cggcaatgag atcccaagca tccccgatgg agctttaaga 300
gacctcagct ctcttcaggt tttcaagttc agctacaaca agctgagagt gatcacagga 360
cagaccctcc agggtctctc taacttaatg aggctgcaca ttgaccacaa caagatcgag 420
tttatccacc ctcaagcttt caacggctta acgtctctga ggctactcca tttggaagga 480
aatctcctcc accagctgca ccccagcacc ttctccacgt tcacattttt ggattatttc 540
agactctcca ccataaggca cctctactta gcagagaaca tggttagaac tcttcctgcc 600
agcatgcttc ggaacatgcc gcttctggag aatctttact tgcagggaaa tccgtggacc 660
tgcgattgtg agatgagatg gtttttggaa tgggatgcaa aatccagagg aattctgaag 720
tgtaaaaagg acaaagctta tgaaggcggt cagttgtgtg caatgtgctt cagtccaaag 780
aagttgtaca aacatgagat acacaagctg aaggacatga cttgtctgaa gccttcaata 840
gagtcccctc tgagacagaa caggagcagg agtattgagg aggagcaaga acaggaagag 900
gatggtggca gccagctcat cctggagaaa ttccaactgc cccagtggag catctctttg 960
aatatgaccg acgagcacgg gaacatggtg aacttggtct gtgacatcaa gaaaccaatg 1020
gatgtgtaca agattcactt gaaccaaacg gatcctccag atattgacat aaatgcaaca 1080
gttgccttgg actttgagtg tccaatgacc cgagaaaact atgaaaagct atggaaattg 1140
atagcatact acagtgaagt tcccgtgaag ctacacagag agctcatgct cagcaaagac 1200
cccagagtca gctaccagta caggcaggat gctgatgagg aagctcttta ctacacaggt 1260
gtgagagccc agattcttgc agaaccagaa tgggtcatgc agccatccat agatatccag 1320
ctgaaccgac gtcagagtac ggccaagaag gtgctacttt cctactacac ccagtattct 1380
caaacaatat ccaccaaaga tacaaggcag gctcggggca gaagctgggt aatgattgag 1440
cctagtggag ctgtgcaaag agatcagact gtcctggaag ggggtccatg ccagttgagc 1500
tgcaacgtga aagcttctga gagtccatct atcttctggg tgcttccaga tggctccatc 1560
ctgaaagcgc ccatggatga cccagacagc aagttctcca ttctcagcag tggctggctg 1620
aggatcaagt ccatggagcc atctgactca ggcttgtacc agtgcattgc tcaagtgagg 1680
gatgaaatgg accgcatggt atatagggta cttgtgcagt ctccctccac tcagccagcc 1740
gagaaagaca cagtgacaat tggcaagaac ccaggggagt cggtgacatt gccttgcaat 1800
gctttagcaa tacccgaagc ccaccttagc tggattcttc caaacagaag gataattaat 1860
gatttggcta acacatcaca tgtatacatg ttgccaaatg gaactctttc catcccaaag 1920
gtccaagtca gtgatagtgg ttactacaga tgtgtggctg tcaaccagca aggggcagac 1980
cattttacgg tgggaatcac agtgaccaag aaagggtctg gcttgccatc caaaagaggc 2040
agacgcccag gtgcaaaggc tctttccaga gtcagagaag acatcgtgga ggatgaaggg 2100
ggctcgggca tgggagatga agagaacact tcaaggagac ttctgcatcc aaaggaccaa 2160
gaggtgttcc tcaaaacaaa ggatgatgcc atcaatggag acaagaaagc caagaaaggg 2220
agaagaaagc tgaaactctg gaagcattcg gaaaaagaac cagagaccaa tgttgcagaa 2280
ggtcgcagag tgtttgaatc tagacgaagg ataaacatgg caaacaaaca gattaatccg 2340
gagcgctggg ctgatatttt agccaaagtc cgtgggaaaa atctccctaa gggcacagaa 2400
gtacccccgt tgattaaaac cacaagtcct ccatccttga gcctagaagt cacaccacct 2460
tttcctgctg tttctccccc ctcagcatct cctgtgcaga cagtaaccag tgctgaagaa 2520
tcctcagcag atgtacctct acttggtgaa gaagagcacg ttttgggtac catttcctca 2580
gccagcatgg ggctagaaca caaccacaat ggagttattc ttgttgaacc tgaagtaaca 2640
agcacacctc tggaggaagt tgttgatgac ctttctgaga agactgagga gataacttcc 2700
actgaaggag acctgaaggg gacagcagcc cctacactta tatctgagcc ttatgaacca 2760
tctcctactc tgcacacatt agacacagtc tatgaaaagc ccacccatga agagacggca 2820
acagagggtt ggtctgcagc agatgttgga tcgtcaccag agcccacatc cagtgagtat 2880
gagcctccat tggatgctgt ctccttggct gagtctgagc ccatgcaata ctttgaccca 2940
gatttggaga ctaagtcaca accagatgag gataagatga aagaagacac ctttgcacac 3000
cttactccaa cccccaccat ctgggttaat gactccagta catcacagtt atttgaggat 3060
tctactatag gggaaccagg tgtcccaggc caatcacatc tacaaggact gacagacaac 3120
atccaccttg tgaaaagtag tctaagcact caagacacct tactgattaa aaagggtatg 3180
aaagagatgt ctcagacact acagggagga aatatgctag agggagaccc cacacactcc 3240
agaagttctg agagtgaggg ccaagagagc aaatccatca ctttgcctga ctccacactg 3300
ggtataatga gcagtatgtc tccagttaag aagcctgcgg aaaccacagt tggtaccctc 3360
ctagacaaag acaccacaac agtaacaaca acaccaaggc aaaaagttgc tccgtcatcc 3420
accatgagca ctcacccttc tcgaaggaga cccaacggga gaaggagatt acgccccaac 3480
aaattccgcc accggcacaa gcaaacccca cccacaactt ttgccccatc agagactttt 3540
tctactcaac caactcaagc acctgacatt aagatttcaa gtcaagtgga gagttctctg 3600
gttcctacag cttgggtgga taacacagtt aataccccca aacagttgga aatggagaag 3660
aatgcagaac ccacatccaa gggaacacca cggagaaaac acgggaagag gccaaacaaa 3720
catcgatata ccccttctac agtgagctca agagcgtccg gatccaagcc cagcccttct 3780
ccagaaaata aacatagaaa cattgttact cccagttcag aaactatact tttgcctaga 3840
actgtttctc tgaaaactga gggcccttat gattccttag attacatgac aaccaccaga 3900
aaaatatatt catcttaccc taaagtccaa gagacacttc cagtcacata taaacccaca 3960
tcagatggaa aagaaattaa ggatgatgtt gccacaaatg ttgacaaaca taaaagtgac 4020
attttagtca ctggtgaatc aattactaat gccataccaa cttctcgctc cttggtctcc 4080
actatgggag aatttaagga agaatcctct cctgtaggct ttccaggaac tccaacctgg 4140
aatccctcaa ggacggccca gcctgggagg ctacagacag acatacctgt taccacttct 4200
ggggaaaatc ttacagaccc tccccttctt aaagagcttg aggatgtgga tttcacttcc 4260
gagtttttgt cctctttgac agtctccaca ccatttcacc aggaagaagc tggttcttcc 4320
acaactctct caagcataaa agtggaggtg gcttcaagtc aggcagaaac caccaccctt 4380
gatcaagatc atcttgaaac cactgtggct attctccttt ctgaaactag accacagaat 4440
cacaccccta ctgctgcccg gatgaaggag ccagcatcct cgtccccatc cacaattctc 4500
atgtctttgg gacaaaccac caccactaag ccagcacttc ccagtccaag aatatctcaa 4560
gcatctagag attccaagga aaatgttttc ttgaattatg tggggaatcc agaaacagaa 4620
gcaaccccag tcaacaatga aggaacacag catatgtcag ggccaaatga attatcaaca 4680
ccctcttccg accgggatgc atttaacttg tctacaaagc tggaattgga aaagcaagta 4740
tttggtagta ggagtctacc acgtggccca gatagccaac gccaggatgg aagagttcat 4800
gcttctcatc aactaaccag agtccctgcc aaacccatcc taccaacagc aacagtgagg 4860
ctacctgaaa tgtccacaca aagcgcttcc agatactttg taacttccca gtcacctcgt 4920
cactggacca acaaaccgga aataactaca tatccttctg gggctttgcc agagaacaaa 4980
cagtttacaa ctccaagatt atcaagtaca acaattcctc tcccattgca catgtccaaa 5040
cccagcattc ctagtaagtt tactgaccga agaactgacc aattcaatgg ttactccaaa 5100
gtgtttggaa ataacaacat ccctgaggca agaaacccag ttggaaagcc tcccagtcca 5160
agaattcctc attattccaa tggaagactc cctttcttta ccaacaagac tctttctttt 5220
ccacagttgg gagtcacccg gagaccccag atacccactt ctcctgcccc agtaatgaga 5280
gagagaaaag ttattccagg ttcctacaac aggatacatt cccatagcac cttccatctg 5340
gactttggcc ctccggcacc tccgttgttg cacactccgc agaccacggg atcaccctca 5400
actaacttac agaatatccc tatggtctct tccacccaga gttctatctc ctttataaca 5460
tcttctgtcc agtcctcagg aagcttccac cagagcagct caaagttctt tgcaggagga 5520
cctcctgcat ccaaattctg gtctcttggg gaaaagcccc aaatcctcac caagtcccca 5580
cagactgtgt ccgtcaccgc tgagacagac actgtgttcc cctgtgaggc aacaggaaaa 5640
ccaaagcctt tcgttacttg gacaaaggtt tccacaggag ctcttatgac tccgaatacc 5700
aggatacaac ggtttgaggt tctcaagaac ggtaccttag tgatacggaa ggttcaagta 5760
caagatcgag gccagtatat gtgcaccgcc agcaacctgc acggcctgga caggatggtg 5820
gtcttgcttt cggtcaccgt gcagcaacct caaatcctag cctcccacta ccaggacgtc 5880
actgtctacc tgggagacac cattgcaatg gagtgtctgg ccaaagggac cccagccccc 5940
caaatttcct ggatcttccc tgacaggagg gtgtggcaaa ctgtgtcccc cgtggagagc 6000
cgcatcaccc tgcacgaaaa ccggaccctt tccatcaagg aggcgtcctt ctcagacaga 6060
ggcgtctata agtgcgtggc cagcaatgca gccggggcgg acagcctggc catccgcctg 6120
cacgtggcgg cactgccccc cgttatccac caggagaagc tggagaacat ctcgctgccc 6180
ccggggctca gcattcacat tcactgcact gccaaggctg cgcccctgcc cagcgtgcgc 6240
tgggtgctcg gggacggtac ccagatccgc ccctcgcagt tcctccacgg gaacttgttt 6300
gttttcccca acgggacgct ctacatccgc aacctcgcgc ccaaggacag cgggcgctat 6360
gagtgcgtgg ccgccaacct ggtaggctcc gcgcgcagga cggtgcagct gaacgtgcag 6420
cgtgcagcag ccaacgcgcg catcacgggc acctccccgc ggaggacgga cgtcaggtac 6480
ggaggaaccc tcaagctgga ctgcagcgcc tcgggggacc cctggccgcg catcctctgg 6540
aggctgccgt ccaagaggat gatcgacgcg ctcttcagtt ttgatagcag aatcaaggtg 6600
tttgccaatg ggaccctggt ggtgaaatca gtgacggaca aagatgccgg agattacctg 6660
tgcgtagctc gaaataaggt tggtgatgac tacgtggtgc tcaaagtgga tgtggtgatg 6720
aaaccggcca agattgaaca caaggaggag aacgaccaca aagtcttcta cgggggtgac 6780
ctgaaagtgg actgtgtggc caccgggctt cccaatcccg agatctcctg gagcctccca 6840
gacgggagtc tggtgaactc cttcatgcag tcggatgaca gcggtggacg caccaagcgc 6900
tatgtcgtct tcaacaatgg gacactctac tttaacgaag tggggatgag ggaggaagga 6960
gactacacct gctttgctga aaatcaggtc gggaaggacg agatgagagt cagagtcaag 7020
gtggtgacag cgcccgccac catccggaac aagacttact tggcggttca ggtgccctat 7080
ggagacgtgg tcactgtagc ctgtgaggcc aaaggagaac ccatgcccaa ggtgacttgg 7140
ttgtccccaa ccaacaaggt gatccccacc tcctctgaga agtatcagat ataccaagat 7200
ggcactctcc ttattcagaa agcccagcgt tctgacagcg gcaactacac ctgcctggtc 7260
aggaacagcg cgggagagga taggaagacg gtgtggattc acgtcaacgt ccagccaccc 7320
aagatcaacg gtaaccccaa ccccatcacc accgtgcggg agatagcagc cgggggcagt 7380
cggaaactga ttgactgcaa agctgaaggc atccccaccc cgagggtgtt atgggctttt 7440
cccgagggtg tggttctgcc agctccatac tatggaaacc ggatcactgt ccatggcaac 7500
ggttccctgg acatcaggag tttgaggaag agcgactccg tccagctggt atgcatggca 7560
cgcaacgagg gaggggaggc gaggttgatc gtgcagctca ctgtcctgga gcccatggag 7620
aaacccatct tccacgaccc gatcagcgag aagatcacgg ccatggcggg ccacaccatc 7680
agcctcaact gctctgccgc ggggaccccg acacccagcc tggtgtgggt ccttcccaat 7740
ggcaccgatc tgcagagtgg acagcagctg cagcgcttct accacaaggc tgacggcatg 7800
ctacacatta gcggtctctc ctcggtggac gctggggcct accgctgcgt ggcccgcaat 7860
gccgctggcc acacggagag gctggtctcc ctgaaggtgg gactgaagcc agaagcaaac 7920
aagcagtatc ataacctggt cagcatcatc aatggtgaga ccctgaagct cccctgcacc 7980
cctcccgggg ctgggcaggg acgtttctcc tggacgctcc ccaatggcat gcatctggag 8040
ggcccccaaa ccctgggacg cgtttctctt ctggacaatg gcaccctcac ggttcgtgag 8100
gcctcggtgt ttgacagggg tacctatgta tgcaggatgg agacggagta cggcccttcg 8160
gtcaccagca tccccgtgat tgtgatcgcc tatcctcccc ggatcaccag cgagcccacc 8220
ccggtcatct acacccggcc cgggaacacc gtgaaactga actgcatggc tatggggatt 8280
cccaaagctg acatcacgtg ggagttaccg gataagtcgc atctgaaggc aggggttcag 8340
gctcgtctgt atggaaacag atttcttcac ccccagggat cactgaccat ccagcatgcc 8400
acacagagag atgccggctt ctacaagtgc atggcaaaaa acattctcgg cagtgactcc 8460
aaaacaactt acatccacgt cttctgaaat gtggattcca gaatgattgc ttaggaactg 8520
acaacaaagc ggggtttgta agggaagcca ggttggggaa taggagctct taaataatgt 8580
gtcacagtgc atggtggcct ctggtgggtt tcaagttgag gttgatcttg atctacaatt 8640
gttgggaaaa ggaagcaatg cagacacgag aaggagggct cagccttgct gagacacttt 8700
cttttgtgtt tacatcatgc caggggcttc attcagggtg tctgtgctct gactgcaatt 8760
tttcttcttt tgcaaatgcc actcgactgc cttcataagc gtccatagga tatctgagga 8820
acattcatca aaaataagcc atagacatga acaacacctc actaccccat tgaagacgca 8880
tcacctagtt aacctgctgc agtttttaca tgatagactt tgttccagat tgacaagtca 8940
tctttcagtt atttcctctg tcacttcaaa actccagctt gcccaataag gatttagaac 9000
cagagtgact gatatatata tatatatttt aattcagagt tacatacata cagctaccat 9060
tttatatgaa aaaagaaaaa catttcttcc tggaactcac tttttatata atgttttata 9120
tatatatttt ttcctttcaa atcagacgat gagactagaa ggagaaatac tttctgtctt 9180
attaaaatta ataaattatt ggtctttaca agacttggat acattacagc agacatggaa 9240
atataatttt aaaaaatttc tctccaacct ccttcaaatt cagtcaccac tgttatatta 9300
ccttctccag gaaccctcca gtggggaagg ctgcgatatt agatttcctt gtatgcaaag 9360
tttttgttga aagctgtgct cagaggaggt gagaggagag gaaggagaaa actgcatcat 9420
aactttacag aattgaatct agagtcttcc ccgaaaagcc cagaaacttc tctgcagtat 9480
ctggcttgtc catctggtct aaggtggctg cttcttcccc agccatgagt cagtttgtgc 9540
ccatgaataa tacacgacct gttatttcca tgactgcttt actgtatttt taaggtcaat 9600
atactgtaca tttgataata aaataatatt ctcccaaaaa aaaaa 9645
<210>96
<211>694
<212>DNA
<213>人类
<400>96
gcctccgagg agaccatggc ctggcccctg tgcaccctgc tgctcctgct ggccacccag 60
gctgtggccc tggcctggag cccccaggag gaggacagga taatcgaggg tggcatctat 120
gatgcagacc tcaatgatga gcgggtacag cgtgcccttc actttgtcat cagcgagtat 180
aacaaggcca ctgaagatga gtactacaga cgcctgctgc gggtgctacg agccagggag 240
cagatcgtgg gcggggtgaa ttacttcttc gacatagagg tgggccgaac catatgtacc 300
aagtcccagc ccaacttgga cacctgtgcc ttccatgaac agccagaact gcagaagaaa 360
cagttgtgct ctttccagat ctacgaagtt ccctgggagg acagaatgtc cctggtgaat 420
tccaggtgtc aagaagccta gggatctgtg ccagggagtc acactgacca cctcctactc 480
ccaccccttg tagtgctccc acccctggac tggtggcccc caccctgtgg gaggtctccc 540
catgcacctg cagcaggaga agacagagaa ggctgcagga ggcctttgtt gctcagcagg 600
ggactctgcc ctccctcctt ccttttgctt ctcatagccc tggtacatgg tacacacacc 660
cccacctcct gcaattaaac agtagcatca cctc 694
<210>97
<211>782
<212>DNA
<213>人类
<400>97
gggctccctg cctcgggctc tcaccctcct ctcctgcagc tccagctttg tgctctgcct 60
ctgaggagac catggcccag tatctgagta ccctgctgct cctgctggcc accctagctg 120
tggccctggc ctggagcccc aaggaggagg ataggataat cccgggtggc atctataacg 180
cagacctcaa tgatgagtgg gtacagcgtg cccttcactt cgccatcagc gagtataaca 240
aggccaccaa agatgactac tacagacgtc cgctgcgggt actaagagcc aggcaacaga 300
ccgttggggg ggtgaattac ttcttcgacg tagaggtggg ccgcaccata tgtaccaagt 360
cccagcccaa cttggacacc tgtgccttcc atgaacagcc agaactgcag aagaaacagt 420
tgtgctcttt cgagatctac gaagttccct gggagaacag aaggtccctg gtgaaatcca 480
ggtgtcaaga atcctaggga tctgtgccag gccattcgca ccagccacca cccactccca 540
ccccctgtag tgctcccacc cctggactgg tggcccccac cctgcgggag gcctccccat 600
gtgcctgcgc caagagacag acagagaagg ctgcaggagt cctttgttgc tcagcagggc 660
gctctgccct ccctccttcc ttcttgcttc taatagccct ggtacatggt acacaccccc 720
ccacctcctg caattaaaca gtagcatcgc ctccctctga aaaaaaaaaa aaaaaaaaaa 780
aa 782
<210>98
<211>3432
<212>DNA
<213>人类
<400>98
actccagcgc gcggctacct acgcttggtg cttgctttct ccagccatcg gagaccagag 60
ccgccccctc tgctcgagaa aggggctcag cggcggcgga agcggagggg gaccaccgtg 120
gagagcgcgg tcccagcccg gccactgcgg atccctgaaa ccaaaaagct cctgctgctt 180
ctgtaccccg cctgtccctc ccagctgcgc agggcccctt cgtgggatca tcagcccgaa 240
gacagggatg gagaggcctc tgtgctccca cctctgcagc tgcctggcta tgctggccct 300
cctgtccccc ctgagcctgg cacagtatga cagctggccc cattaccccg agtacttcca 360
gcaaccggct cctgagtatc accagcccca ggcccccgcc aacgtggcca agattcagct 420
gcgcctggct gggcagaaga ggaagcacag cgagggccgg gtggaggtgt actatgatgg 480
ccagtggggc accgtgtgcg atgacgactt ctccatccac gctgcccacg tcgtctgccg 540
ggagctgggc tatgtggagg ccaagtcctg gactgccagc tcctcctacg gcaagggaga 600
agggcccatc tggttagaca atctccactg tactggcaac gaggcgaccc ttgcagcatg 660
cacctccaat ggctggggcg tcactgactg caagcacacg gaggatgtcg gtgtggtgtg 720
cagcgacaaa aggattcctg ggttcaaatt tgacaattcg ttgatcaacc agatagagaa 780
cctgaatatc caggtggagg acattcggat tcgagccatc ctctcaacct accgcaagcg 840
caccccagtg atggagggct acgtggaggt gaaggagggc aagacctgga agcagatctg 900
tgacaagcac tggacggcca agaattcccg cgtggtctgc ggcatgtttg gcttccctgg 960
ggagaggaca tacaatacca aagtgtacaa aatgtttgcc tcacggagga agcagcgcta 1020
ctggccattc tccatggact gcaccggcac agaggcccac atctccagct gcaagctggg 1080
cccccaggtg tcactggacc ccatgaagaa tgtcacctgc gagaatgggc tgccggccgt 1140
ggtgagttgt gtgcctgggc aggtcttcag ccctgacgga ccctcgagat tccggaaagc 1200
atacaagcca gagcaacccc tggtgcgact gagaggcggt gcctacatcg gggagggccg 1260
cgtggaggtg ctcaaaaatg gagaatgggg gaccgtctgc gacgacaagt gggacctggt 1320
gtcggccagt gtggtctgca gagagctggg ctttgggagt gccaaagagg cagtcactgg 1380
ctcccgactg gggcaaggga tcggacccat ccacctcaac gagatccagt gcacaggcaa 1440
tgagaagtcc attatagact gcaagttcaa tgccgagtct cagggctgca accacgagga 1500
ggatgctggt gtgagatgca acacccctgc catgggcttg cagaagaagc tgcgcctgaa 1560
cggcggccgc aatccctacg agggccgagt ggaggtgctg gtggagagaa acgggtccct 1620
tgtgtggggg atggtgtgtg gccaaaactg gggcatcgtg gaggccatgg tggtctgccg 1680
ccagctgggc ctgggattcg ccagcaacgc cttccaggag acctggtatt ggcacggaga 1740
tgtcaacagc aacaaagtgg tcatgagtgg agtgaagtgc tcgggaacgg agctgtccct 1800
ggcgcactgc cgccacgacg gggaggacgt ggcctgcccc cagggcggag tgcagtacgg 1860
ggccggagtt gcctgctcag aaaccgcccc tgacctggtc ctcaatgcgg agatggtgca 1920
gcagaccacc tacctggagg accggcccat gttcatgctg cagtgtgcca tggaggagaa 1980
ctgcctctcg gcctcagccg cgcagaccga ccccaccacg ggctaccgcc ggctcctgcg 2040
cttctcctcc cagatccaca acaatggcca gtccgacttc cggcccaaga acggccgcca 2100
cgcgtggatc tggcacgact gtcacaggca ctaccacagc atggaggtgt tcacccacta 2160
tgacctgctg aacctcaatg gcaccaaggt ggcagagggc cacaaggcca gcttctgctt 2220
ggaggacaca gaatgtgaag gagacatcca gaagaattac gagtgtgcca acttcggcga 2280
tcagggcatc accatgggct gctgggacat gtaccgccat gacatcgact gccagtgggt 2340
tgacatcact gacgtgcccc ctggagacta cctgttccag gttgttatta accccaactt 2400
cgaggttgca gaatccgatt actccaacaa catcatgaaa tgcaggagcc gctatgacgg 2460
ccaccgcatc tggatgtaca actgccacat aggtggttcc ttcagcgaag agacggaaaa 2520
aaagtttgag cacttcagcg ggctcttaaa caaccagctg tccccgcagt aaagaagcct 2580
gcgtggtcaa ctcctgtctt caggccacac cacatcttcc atgggacttc cccccaacaa 2640
ctgagtctga acgaatgcca cgtgccctca cccagcccgg cccccaccct gtccagaccc 2700
ctacagctgt gtctaagctc aggaggaaag ggaccctccc atcattcatg gggggctgct 2760
acctgaccct tggggcctga gaaggccttg ggggggtggg gtttgtccac agagctgctg 2820
gagcagcacc aagagccagt cttgaccggg atgaggccca cagacaggtt gtcatcagct 2880
tgtcccattc aagccaccga gctcaccaca gacacagtgg agccgcgctc ttctccagtg 2940
acacgtggac aaatgcgggc tcatcagccc ccccagagag ggtcaggccg aaccccattt 3000
ctcctcctct taggtcattt tcagcaaact tgaatatcta gacctctctt ccaatgaaac 3060
cctccagtct attatagtca catagataat ggtgccacgt gttttctgat ttggtgagct 3120
cagacttggt gcttccctct ccacaacccc caccccttgt ttttcaagat actattatta 3180
tattttcaca gacttttgaa gcacaaattt attggcattt aatattggac atctgggccc 3240
ttggaagtac aaatctaagg aaaaaccaac ccactgtgta agtgactcat cttcctgttg 3300
ttccaattct gtgggttttt gattcaacgg tgctataacc agggtcctgg gtgacagggc 3360
gctcactgag caccatgtgt catcacagac acttacacat acttgaaact tggaataaaa 3420
gaaagattta tg 3432
<210>99
<211>8448
<212>DNA
<213>人类
<400>99
gcagtggttt ctcctccttc ctcccaggaa gggccaggaa aatggccctg gtcctggaga 60
tcttcaccct gctggcctcc atctgctggg tgtcggccaa tatcttcgag taccaggttg 120
atgcccagcc ccttcgtccc tgtgagctgc agagggaaac ggcctttctg aagcaagcag 180
actacgtgcc ccagtgtgca gaggatggca gcttccagac tgtccagtgc cagaacgacg 240
gccgctcctg ctggtgtgtg ggtgccaacg gcagtgaagt gctgggcagc aggcagccag 300
gacggcctgt ggcttgtctg tcattttgtc agctacagaa acagcagatc ttactgagtg 360
gctacattaa cagcacagac acctcctacc tccctcagtg tcaggattca ggggactacg 420
cgcctgttca gtgtgatgtg cagcatgtcc agtgctggtg tgtggacgca gaggggatgg 480
aggtgtatgg gacccgccag ctggggaggc caaagcgatg tccaaggagc tgtgaaataa 540
gaaatcgtcg tcttctccac ggggtgggag ataagtcacc accccagtgt tctgcggagg 600
gagagtttat gcctgtctag tgcaaatttg tcaacaccac agacatgatg atttttgatc 660
tggtccacag ctacaacagg tttccagatg catttgtgac cttcagttcc ttccagagga 720
ggttccctga ggtatctggg tattgccact gtgctgacag ccaagggcgg gaactggctg 780
agacaggttt ggagttgtta ctggatgaaa tttatgacac catttttgct ggcctggacc 840
ttccttccac cttcactgaa accaccctgt accggatact gcagagacgg ttcctcgcag 900
ttcaatcagt catctctggc agattccgat gccccacaaa atgtgaagtg gagcggttta 960
cagcaaccag ctttggtcac ccctatgttc caagctgccg ccgaaatggc gactatcagg 1020
cggtgcagtg ccagacggaa gggccctgct ggtgtgtgga cgcccagggg aaggaaatgc 1080
atggaacccg gcagcaaggg gagccgccat cttgtgctga aggccaatct tgtgcctccg 1140
aaaggcagca ggccttgtcc agactctact ttgggacctc aggctacttc agccagcacg 1200
acctgttctc ttccccagag aaaagatggg cctctccaag agtagccaga tttgccacat 1260
cctgcccacc cacgatcaag gagctctttg tggactctgg gcttctccgc ccaatggtgg 1320
agggacagag ccaacagttt tctgtctcag aaaatcttct caaagaagcc atccgagcaa 1380
tttttccctc ccgagggctg gctcgtcttg cccttcagtt taccaccaac ccaaagagac 1440
tccagcaaaa cctttttgga gggaaatttt tggtgaatgt tggccagttt aacttgtctg 1500
gagcccttgg cacaagaggc acatttaact tcagtcaatt tttccagcaa cttggtcttg 1560
caagcttctt gaatggaggg agacaagaag atttggccaa gccactctct gtgggattag 1620
attcaaattc ttccacagga acccctgaag ctgctaagaa ggatggtact atgaataagc 1680
caactgtggg cagctttggc tttgaaatta acctacaaga gaaccaaaat gccctcaaat 1740
tccttgcttc tctcctggag cttccagaat tccttctctt cttgcaacat gctatctctg 1800
tgccagaaga tgtggcaaga gatttaggtg atgtgatgga aacggtactc gactcccaga 1860
cctgtgagca gacacctgaa aggctatttg tcccatcatg cacgacagaa ggaagctatg 1920
aggatgtcca atgcttttcc ggagagtgct ggtgtgtgaa ttcctggggc aaagagcttc 1980
caggctcaag agtcagagat ggacagccaa ggtgccccac agactgtgaa aagcaaaggg 2040
ctcgcatgca aagcctcatg ggcagccagc ctgctggctc caccttgttt gtccctgctt 2100
gtactagtga gggacatttc ctgcctgtcc agtgcttcaa ctcagagtgc tactgtgttg 2160
atgctgaggg tcaggccatt cctggaactc gaagtgcaat agggaagccc aagaaatgcc 2220
ccacgccctg tcaattacag tctgagcaag ctttcctcag gacggtgcag gccctgctct 2280
ctaactccag catgctaccc accctttccg acacctacat cccacagtgc agcaccgatg 2340
ggcagtggag acaagtgcaa tgcaatgggc ctcctgagca ggtcttcgag ttgtaccaac 2400
gatgggaggc tcagaacaag ggccaggatc tgacgcctgc caagctgcta gtgaagatca 2460
tgagctacag agaagcagct tccggaaact tcagtctctt tattcaaagt ctgtatgagg 2520
ctggccagca agatgtcttc ccggtgctgt cacaataccc ttctctgcaa gatgtcccac 2580
tagcagcact ggaagggaaa cggccccagc ccagggagaa tatcctcctg gagccctacc 2640
tcttctggca gatcttaaat ggccaactca gccaataccc ggggtcctac tcagacttca 2700
gcactccttt ggcacatttt gatcttcgga actgctggtg tgtggatgag gctggccaag 2760
aactggaagg aatgcggtct gagccaagca agctcccaac gtgtcctggc tcctgtgagg 2820
aagcaaagct ccgtgtactg cagttcatta gggaaacgga agagattgtt tcagcttcca 2880
acagttctcg gttccctctg ggggagagtt tcctggtggc caagggaatc cggctgagga 2940
atgaggacct cggccttcct ccgctcttcc cgccccggga ggctttcgcg gagtttctgc 3000
gtgggagtga ttacgccatt cgcctggcgg ctcagtctac cttaagcttc tatcagagac 3060
gccgcttttc cccggacgac tcggctggag catccgccct tctgcggtcg ggcccctaca 3120
tgccacagtg tgatgcgttt ggaagttggg agcctgtgca gtgccacgct gggactgggc 3180
actgctggtg tgtagatgag aaaggagggt tcatccctgg ctcactgact gcccgctctc 3240
tgcagattcc acagtgcccg acaacctgcg agaaatctcg aaccagtggg ctgctttcca 3300
gttggaaaca ggctagatcc caagaaaacc catctccaaa agacctgttc gtcccagcct 3360
gcctagaaac aggagaatat gccaggctgc aggcatcggg ggctggcacc tggtgtgtgg 3420
accctgcatc aggagaagag ttgcggcctg gctcgagcag cagtgcccag tgcccaagcc 3480
tctgcaatgt gctcaagagt ggagtcctct ctaggagagt cagcccaggc tatgtcccag 3540
cctgcagggc agaggatggg ggcttttccc cagtgcaatg tgaccaggcc cagggcagct 3600
gctggtgtgt catggacagc ggagaagagg tgcctgggac gcgcgtgacc gggggccagc 3660
ccgcctgtga gagcccgcgg tgtccgctgc cattcaacgc gtcggaggtg gttggtggaa 3720
caatcctgtg tgagacaatc tcgggcccca caggctctgc catgcagcag tgccaattgc 3780
tgtgccgcca aggctcctgg agcgtgtttc caccagggcc attgatatgt agcctggaga 3840
gcggacgctg ggagtcacag ctgcctcagc cccgggcctg ccaacggccc cagctgtggc 3900
agaccatcca gacccaaggg cactttcagc tccagctccc gccgggcaag atgtgcagtg 3960
ctgactacgc gggtttgctg cagactttcc aggttttcat attggatgag ctgacagccc 4020
gcggcttctg ccagatccag gtgaagactt ttggcaccct ggtttccatt cctgtctgca 4080
acaactcctc tgtgcaggtg ggttgtctga ccagggagcg tttaggagtg aatgttacat 4140
ggaaatcacg gcttgaggac atcccagtgg cttctcttcc tgacttacat gacattgaga 4200
gagccttggt gggcaaggat ctccttgggc gcttcacaga tctgatccag agtggctcat 4260
tccagcttca tctggactcc aagacgttcc cagcggaaac catccgcttc ctccaagggg 4320
accactttgg cacctctcct aggacacggt ttgggtgctc ggaaggattc taccaagtct 4380
tgacaagtga ggccagtcag gacggactgg gatgcgttaa gtgccatgaa ggaagctatt 4440
cccaagatga ggaatgcatt ccttgtcctg ttggattcta ccaagaacag gcagggagct 4500
tggcctgtgt cccatgtcct gtgggcagaa cgaccatttc tgccggagct ttcagccaga 4560
ctcactgtgt cactgactgt cagaggaacg aagcaggcct gcaatgtgac cagaatggcc 4620
agtatcgagc cagccagaag gacaggggca gtgggaaggc cttctgtgtg gacggcgagg 4680
ggcggaggct gccatggtgg gaaacagagg cccctcttga ggactcacag tgtttgatga 4740
tgcagaagtt tgagaaggtt ccagaatcaa aggtgatctt cgacgccaat gctcctgtgg 4800
ctgtcagatc caaagttcct gattctgagt tccccgtgat gcagtgcttg acagattgca 4860
cagaggacga ggcctgcagc ttcttcaccg tgtccacgac ggagccagag atttcctgtg 4920
atttctatgc ttggacaagt gacaatgttg cctgcatgac ttctgaccag aaacgagatg 4980
cactggggaa ctcaaaggcc accagctttg gaagtcttcg ctgccaggtg aaagtgagga 5040
gccatggtca agattctcca gctgtgtatt tgaaaaaggg ccaaggatcc accacaacac 5100
ttcagaaacg ctttgaaccc actggtttcc aaaacatgct ttctggattg tacaacccca 5160
ttgtgttctc agcctcagga gccaatctaa ccgatgctca cctcttctgt cttcttgcat 5220
gcgaccgtga tctgtgttgc gatggcttcg tcctcacaca ggttcaagga ggtgccatca 5280
tctgtgggtt gctgagctca cccagtgtcc tgctttgtaa tgtcaaagac tggatggatc 5340
cctctgaagc ctgggctaat gctacatgtc ctggtgtgac atatgaccag gagagccacc 5400
aggtgatatt gcgtcttgga gaccaggagt tcatcaagag tctgacaccc ttagaaggaa 5460
ctcaagacac ctttaccaat tttcagcagg tttatctctg gaaagattct gacatggggt 5520
ctcggcctga gtctatggga tgtagaaaaa acacagtgcc aaggccagca tctccaacag 5580
aagcaggttt gacaacagaa cttttctccc ctgtggacct caaccaggtc attgtcaatg 5640
gaaatcaatc actatccagc cagaagcact ggcttttcaa gcacctgttt tcagcccagc 5700
aggcaaacct atggtgcctt tctcgttgtg tgcaggagca ctctttctgt cagctcgcag 5760
agataacaga gagtgcatcc ttgtacttca cctgcaccct ctacccagag gcacaggtgt 5820
gtgatgacat catggagtcc aatacccagg gctgcagact gatcctgcct cagatgccaa 5880
aggccctgtt ccggaagaaa gttatactgg aagataaagt gaagaacttt tacactcgcc 5940
tgccgttcca aaaactgatg gggatatcca ttagaaataa agtgcccatg tctgaaaaat 6000
ctatttctaa tgggttcttt gaatgtgaac gacggtgcga tgcggaccca tgctgcactg 6060
gctttggatt tctaaatgtt tcccagttaa aaggaggaga ggtgacatgt ctcactctga 6120
acagcttggg aattcagatg tgcagtgagg agaatggagg agcctggcgc attttggact 6180
gtggctctcc tgacattgaa gtccacacct atcccttcgg atggtaccag aagcccattg 6240
ctcaaaataa tgctcccagt ttttgccctt tggttgttct gccttccctc acagagaaag 6300
tgtctctgga atcgtggcag tccctggccc tctcttcagt ggttgttgat ccatccatta 6360
ggcactttga tgttgcccat gtcagcactg ctgccaccag caatttctct gctgtccgag 6420
acctctgttt gtcggaatgt tcccaacatg aggcctgtct catcaccact ctgcaaaccc 6480
aactcggggc tgtgagatgt atgttctatg ctgatactca aagctgcaca catagtctgc 6540
agggtcggaa ctgccgactt ctgcttcgtg aagaggccac ccacatctac cggaagccag 6600
gaatctctct gctcagctat gaggcatctg taccttctgt gcccatttcc acccatggcc 6660
ggctgctggg caggtcccag gccatccagg tgggtacctc atggaagcaa gtggaccagt 6720
tccttggagt tccatatgct gccccgcccc tggcagagag gcacttccag gcaccagagc 6780
ccttgaactg gacaggctcc tgggatgcca gcaagccaag ggccagctgc tggcagccag 6840
gcaccagaac atccacgtct cctggagtca gtgaagattg tttgtatctc aatgtgttca 6900
tccctcagaa tgtggcccct aacgcgtctg tgctggtgtt cttccacaac accatggaca 6960
gggaggagag tgaaggatgg ccggctatcg acggctcctt cttggctgct gttggcaacc 7020
tcatcgtggt cactgccagc taccgagtgg gtgtcttcgg cttcctgagt tctggatccg 7080
gagaggtgag tggcaactgg gggctgctgg accaggtggc ggctctgacc tgggtgcaga 7140
cccacatccg aggatttggc ggggaccctc ggcgcgtgtc cctggcagca gaccgtggcg 7200
gggctgatgt ggccagcatc caccttctca cggccagggc caccaactcc caacttttcc 7260
ggagagctgt gctgatggga ggctccgcac tctccccggc cgccgtcatc agccatgaga 7320
gggctcagca gcaggcaatt gctttggcaa aggaggtcag ttgccccatg tcatccagcc 7380
aagaagtggt gtcctgcctc cgccagaagc ctgccaatgt cctcaatgat gcccagacca 7440
agctcctggc cgtgagtggc cctttccact actggggtcc tgtgatcgat ggccacttcc 7500
tccgtgagcc tccagccaga gcactgaaga ggtctttatg ggtagaggtc gatctgctca 7560
ttgggagttc tcaggacgac gggctcatca acagagcaaa ggctgtgaag caatttgagg 7620
aaagtcgagg ccggaccagt agcaaaacag ccttttacca ggcactgcag aattctctgg 7680
gtggcgagga ctcagatgcc cgcgtcgagg ctgctgctac atggtattac tctctggagc 7740
actccacgga tgactatgcc tccttctccc gggctctgga gaatgccacc cgggactact 7800
ttatcatctg ccctataatc gacatggcca gtgcctgggc aaagagggcc cgaggaaacg 7860
tcttcatgta ccatgctcct gaaaactacg gccatggcag cctggagctg ctggcggatg 7920
ttcagtttgc cttggggctt cccttctacc cagcctacga ggggcagttt tctctggagg 7980
agaagagcct gtcgctgaaa atcatgcagt acttttccca cttcatcaga tcaggaaatc 8040
ccaactaccc ttatgagttc tcacggaaag tacccacatt tgcaaccccc tggcctgact 8100
ttgtaccccg tgctggtgga gagaactaca aggagttcag tgagctgctc cccaatcgac 8160
agggcctgaa gaaagccgac tgctccttct ggtccaagta catctcgtct ctgaagacat 8220
ctgcagatgg agccaagggc gggcagtcag cagagagtga agaggaggag ttgacggctg 8280
gatctgggct aagagaagat ctcctaagcc tccaggaacc aggctctaag acctacagca 8340
agtgaccagc ccttgagctc cccaaaaacc tcacccgagg ctgcccacta tggtcatctt 8400
tttctctaaa atagttactt accttcaata aagtatctac atgcggtg 8448
<210>100
<211>2745
<212>DNA
<213>人类
<400>100
gcagtggttt ctcctccttc ctcccaggaa gggccaggaa aatggccctg gtcctggaga 60
tcttcaccct gctggcctcc atctgctggg tgtcggccaa tatcttcgag taccaggttg 120
atgcccagcc ccttcgtccc tgtgagctgc agagggaaac ggcctttctg aagcaagcag 180
actacgtgcc ccagtgtgca gaggatggca gcttccagac tgtccagtgc cagaacgacg 240
gccgctcctg ctggtgtgtg ggtgccaacg gcagtgaagt gctgggcagc aggcagccag 300
gacggcctgt ggcttgtctg tcattttgtc agctacagaa acagcagatc ttactgagtg 360
gctacattaa cagcacagac acctcctacc tccctcagtg tcaggattca ggggactacg 420
cgcctgttca gtgtgatgtg cagcatgtcc agtgctggtg tgtggacgca gaggggatgg 480
aggtgtatgg gacccgccag ctggggaggc caaagcgatg tccaaggagc tgtgaaataa 540
gaaatcgtcg tcttctccac ggggtgggag ataagtcacc accccagtgt tctgcggagg 600
gagagtttat gcctgtccag tgcaaatttg tcaacaccac agacatgatg atttttgatc 660
tggtccacag ctacaacagg tttccagatg catttgtgac cttcagttcc ttccagagga 720
ggttccctga ggtatctggg tattgccact gtgctgacag ccaagggcgg gaactggctg 780
agacaggttt ggagttgtta ctggatgaaa tttatgacac catttttgct ggcctggacc 840
ttccttccac cttcactgaa accaccctgt accggatact gcagagacgg ttcctcgcag 900
ttcaatcagt catctctggc agattccgat gccccacaaa atgtgaagtg gagcggttta 960
cagcaaccag ctttggtcac ccctatgttc caagctgccg ccgaaatggc gactatcagg 1020
cggtgcagtg ccagacggaa gggccctgct ggtgtgtgga cgcccagggg aaggaaatgc 1080
atggaacccg gcagcaaggg gagccgccat cttgtgctga aggccaatct tgtgcctccg 1140
aaaggcagca ggccttgtcc agactctact ttgggacctc aggctacttc agccagcacg 1200
acctgttctc ttccccagag aaaagatggg cctctccaag agtagccaga tttgccacat 1260
cctgcccacc cacgatcaag gagctctttg tggactctgg gcttctccgc ccaatggtgg 1320
agggacagag ccaacagttt tctgtctcag aaaatcttct caaagaagcc atccgagcaa 1380
tttttccctc ccgagggctg gctcgtcttg cccttcagtt taccaccaac ccaaagagac 1440
tccagcaaaa cctttttgga gggaaatttt tggtgaatgt tggccagttt aacttgtctg 1500
gagcccttgg cacaagaggc acatttaact tcagtcaatt tttccagcaa cttggtcttg 1560
caagcttctt gaatggaggg agacaagaag atttggccaa gccactctct gtgggattag 1620
attcaaattc ttccacagga acccctgaag ctgctaagaa ggatggtact atgaataagc 1680
caactgtggg cagctttggc tttgaaatta acctacaaga gaaccaaaat gccctcaaat 1740
tccttgcttc tctcctggag cttccagaat tccttctctt cttgcaacat gctatctctg 1800
tgccagaaga tgtggcaaga gatttaggtg atgtgatgga aacggtactc gactcccaga 1860
cctgtgagca gacacctgaa aggctatttg tcccatcatg cacgacagaa ggaagctatg 1920
aggatgtcca atgcttttcc ggagagtgct ggtgtgtgaa ttcctggggc aaagagcttc 1980
caggctcaag agtcagagat ggacagccaa ggtgccccac agactgtgaa aagcaaaggg 2040
ctcgcatgca aagcctcatg ggcagccagc ctgctggctc caccttgttt gtccctgctt 2100
gtactagtga gggacatttc ctgcctgtcc agtgcttcaa ctcagagtgc tactgtgttg 2160
atgctgaggg tcaggccatt cctggaactc gaagtgcaat agggaagccc aagaaatgcc 2220
ccacgccctg tcaattacag tctgagcaag ctttcctcag gacggtgcag gccctgctct 2280
acctccctcc gcggagcagc cagacagcga gggccccggc cgggggcagg ggggacgccc 2340
cgtccggggc accccccccg gctctgagcc gcccgcgggg ccggcctcgg cccggagcgg 2400
aggaaggagt cgccgaggag cagcctgagg ccccagagtc tgagacgagc cgccgccgcc 2460
cccgccactg cggggaggag ggggaggagg agcgggagga gggacgagct ggtcgggaga 2520
agaggaaaaa aacttttgag acttttccgt tgccgctggg agccggaggc gcggggacct 2580
cttggcgcga cgctgccccg cgaggaggca ggacttgggg accccagacc gcctcccttt 2640
gccgccgggg acgcttgctc cctccctgcc ccctacacgg cgtccctcag gcgcccccat 2700
tccggaccag ccctcgggag tcgccgaccc ggcctcccgc aaagactttt ccccagacct 2760
cgggcgcacc ccctgcacgc cgccttcatc cccggcctgt ctcctgagcc cccgcgcatc 2820
ctagaccctt tctcctccag gagacggatc tctctccgac ctgccacaga tcccctattc 2880
aagaccaccc accttctggt accagatcgc gcccatctag gttatttccg tgggatactg 2940
agacaccccc ggtccaagcc tcccctccac cactgcgccc ttctccctga ggagcctcag 3000
ctttccctcg aggccctcct accttttgcc gggagacccc cagcccctgc aggggcgggg 3060
cctccccacc acaccagccc tgttcgcgct ctcggcagtg ccggggggcg ccgcctcccc 3120
catgccgccc tccgggctgc ggctgctgcc gctgctgcta ccgctgctgt ggctactggt 3180
gctgacgcct ggcccgccgg ccgcgggact atccacctgc aagactatcg acatggagct 3240
ggtgaagcgg aagcgcatcg aggccatccg cggccagatc ctgtccaagc tgcggctcgc 3300
cagccccccg agccaggggg aggtgccgcc cggcccgctg cccgaggccg tgctcgccct 3360
gtacaacagc acccgcgacc gggtggccgg ggagagtgca gaaccggagc ccgagcctga 3420
ggccgactac tacgccaagg aggtcacccg cgtgctaatg gtggaaaccc acaacgaaat 3480
ctatgacaag ttcaagcaga gtacacacag catatatatg ttcttcaaca catcagagct 3540
ccgagaagcg gtacctgaac ccgtgttgct ctcccgggca gagctgcgtc tgctgaggag 3600
gctcaagtta aaagtggagc agcacgtgga gctgtaccag aaatacagca acaattcctg 3660
gcgatacctc agcaaccggc tgctggcacc cagcgactcg ccagagtggt tatcttttga 3720
tgtcaccgga gttgtgcggc agtggttgag ccgtggaggg gaaattgagg gctttcgcct 3780
tagcgcccac tgctcctgtg acagcaggga taacacactg caagtggaca tcaacgggtt 3840
cactaccggc cgccgaggtg acctggccac cattcatggc atgaaccggc ctttcctgct 3900
tctcatggcc accccgctgg agagggccca gcatctgcaa agctcccggc accgccgagc 3960
cctggacacc aactattgct tcagctccac ggagaagaac tgctgcgtgc ggcagctgta 4020
cattgacttc cgcaaggacc tcggctggaa gtggatccac gagcccaagg gctaccatgc 4080
caacttctgc ctcgggccct gcccctacat ttggagcctg gacacgcagt acagcaaggt 4140
cctggccctg tacaaccagc ataacccggg cgcctcggcg gcgccgtgct gcgtgccgca 4200
ggcgctggag ccgctgccca tcgtgtacta cgtgggccgc aagcccaagg tggagcagct 4260
gtccaacatg atcgtgcgct cctgcaagtg cagctgaggt cccgccccgc cccgccccgc 4320
cccggcaggc ccggccccac cccgccccgc ccccgctgcc ttgcccatgg gggctgtatt 4380
taaggacacc gtgccccaag cccacctggg gccccattaa agatggagag aggactgcgg 4440
atctctgtgt cattgggcgc ctgcctgggg tctccatccc tgacgttccc ccactcccac 4500
tccctctctc tccctctctg cctcctcctg cctgtctgca ctattccttt gcccggcatc 4560
aaggcacagg ggaccagtgg ggaacactac tgtagttaga tctatttatt gagcaccttg 4620
ggcactgttg aagtgcctta cattaatgaa ctcattcagt caccatagca acactctgag 4680
atggcaggga ctctgataac acccatttta aaggttgagg aaacaagccc agagaggtta 4740
agggaggagt tcctgcccac caggaacctg ctttagtggg ggatagtgaa gaagacaata 4800
aaagatagta gttcaggcca ggcggggtgc tcacgcctgt aatcctagca cttttgggag 4860
gcagagatgg gaggatactt gaatccaggc atttgagacc agcctgggta acatagtgag 4920
accctatctc tacaaaacac ttttaaaaaa tgtacacctg tggtcccagc tactctggag 4980
gctaaggtgg gaggatcact tgatcctggg aggtcaaggc tgcag 5025
<210>101
<211>2208
<212>DNA
<213>人类
<400>101
tctttggctt tttttggcgg agctggggcg ccctccggaa gcgtttccaa ctttccagaa 60
gtttctcggg acgggcagga gggggtgggg actgccatat atagatcccg ggagcagggg 120
agcgggctaa gagtagaatc gtgtcgcggc tcgagagcga gagtcacgtc ccggcgctag 180
cccagcccga cccaggccca ccgtggtgca cgcaaaccac ttcctggcca tgcgctccct 240
cctgcttctc agcgccttct gcctcctgga ggcggccctg gccgccgagg tgaagaaacc 300
tgcagccgca gcagctcctg gcactgcgga gaagttgagc cccaaggcgg ccacgcttgc 360
cgagcgcagc gccggcctgg ccttcagctt gtaccaggcc atggccaagg accaggcagt 420
ggagaacatc ctggtgtcac ccgtggtggt ggcctcgtcg ctagggctcg tgtcgctggg 480
cggcaaggcg accacggcgt cgcaggccaa ggcagtgctg agcgccgagc agctgcgcga 540
cgaggaggtg cacgccggcc tgggcgagct gctgcgctca ctcagcaact ccacggcgcg 600
caacgtgacc tggaagctgg gcagccgact gtacggaccc agctcagtga gcttcgctga 660
tgacttcgtg cgcagcagca agcagcacta caactgcgag cactccaaga tcaacttccg 720
cgacaagcgc agcgcgctgc agtccatcaa cgagtgggcc gcgcagacca ccgacggcaa 780
gctgcccgag gtcaccaagg acgtggagcg cacggacggc gccctgctag tcaacgccat 840
gttcttcaag ccacactggg atgagaaatt ccaccacaag atggtggaca accgtggctt 900
catggtgact cggtcctata ccgtgggtgt catgatgatg caccggacag gcctctacaa 960
ctactacgac gacgagaagg aaaagctgca aatcgtggag atgcccctgg cccacaagct 1020
ctccagcctc atcatcctca tgccccatca cgtggagcct ctcgagcgcc ttgaaaagct 1080
gctaaccaaa gagcagctga agatctggat ggggaagatg cagaagaagg ctgttgccat 1140
ctccttgccc aagggtgtgg tggaggtgac ccatgacctg cagaaacacc tggctgggct 1200
gggcctgact gaggccattg acaagaacaa ggccgacttg tcacgcatgt caggcaagaa 1260
ggacctgtac ctggccagcg tgttccacgc caccgccttt gagttggaca cagatggcaa 1320
cccctttgac caggacatct acgggcgcga ggagctgcgc agccccaagc tgttctacgc 1380
cgaccacccc ttcatcttcc tagtgcggga cacccaaagc ggctccctgc tattcattgg 1440
gcgcctggtc cggcctaagg gtgacaagat gcgagacgag ttatagggcc tcagggtgca 1500
cacaggatgg caggaggcat ccaaaggctc ctgagacaca tgggtgctat tggggttggg 1560
ggggaggtga ggtaccagcc ttggatactc catggggtgg gggtggaaaa acagaccggg 1620
gttcccgtgt gcctgagcgg accttcccag ctagaattca ctccacttgg acatgggccc 1680
cagataccat gatgctgagc ccggaaactc cacatcctgt gggacctggg ccatagtcat 1740
tctgcctgcc ctgaaagtcc cagatcaagc ctgcctcaat cagtattcat atttatagcc 1800
aggtaccttc tcacctgtga gaccaaattg agctaggggg gtcagccagc cctcttctga 1860
cactaaaaca cctcagctgc ctccccagct ctatcccaac ctctcccaac tataaaacta 1920
ggtgctgcag cccctgggac caggcacccc cagaatgacc tggccgcagt gaggcggatt 1980
gagaaggagc tcccaggagg ggcttctggg cagactctgg tcaagaagca tcgtgtctgg 2040
cgttgtgggg atgaactttt tgttttgttt cttccttttt tagttcttca aagataggga 2100
gggaaggggg aacatgagcc tttgttgcta tcaatccaag aacttatttg tacatttttt 2160
ttttcaataa aacttttcca atgacatttt gttggagcgt ggaaaaaa 2208
<210>102
<211>2566
<212>DNA
<213>人类
<400>102
ggcacgagtt gtgctcctcg cttgcctgtt ccttttccac gcattttcca ggataactgt 60
gactccaggc ccgcaatgga tgccctgcaa ctagcaaatt cggcttttgc cgttgatctg 120
ttcaaacaac tatgtgaaaa ggagccactg ggcaatgtcc tcttctctcc aatctgtctc 180
tccacctctc tgtcacttgc tcaagtgggt gctaaaggtg acactgcaaa tgaaattgga 240
caggttcttc attttgaaaa tgtcaaagat ataccctttg gatttcaaac agtaacatcg 300
gatgtaaaca aacttagttc cttttactca ctgaaactaa tcaagcggct ctacgtagac 360
aaatctctga atctttctac agagttcatc agctctacga agagacccta tgcaaaggaa 420
ttggaaactg ttgacttcaa agataaattg gaagaaacga aaggtcagat caacaactca 480
attaaggatc tcacagatgg ccactttgag aacattttag ctgacaacag tgtgaacgac 540
cagaccaaaa tccttgtggt taatgctgcc tactttgttg gcaagtggat gaagaaattt 600
cctgaatcag aaacaaaaga atgtcctttc agactcaaca agacagacac caaaccagtg 660
cagatgatga acatggaggc cacgttctgt atgggaaaca ttgacagtat caattgtaag 720
atcatagagc ttccttttca aaataagcat ctcagcatgt tcatcctact acccaaggat 780
gtggaggatg agtccacagg cttggagaag attgaaaaac aactcaactc agagtcactg 840
tcacagtgga ctaatcccag caccatggcc aatgccaagg tcaaactctc cattccaaaa 900
tttaaggtgg aaaagatgat tgatcccaag gcttgtctgg aaaatctagg gctgaaacat 960
atcttcagtg aagacacatc tgatttctct ggaatgtcag agaccaaggg agtggcccta 1020
tcaaatgtta tccacaaagt gtgcttagaa ataactgaag atggtgggga ttccatagag 1080
gtgccaggag cacggatcct gcagcacaag gatgaattga atgctgacca tccctttatt 1140
tacatcatca ggcacaacaa aactcgaaac atcattttct ttggcaaatt ctgttctcct 1200
taagtggcat agcccatgtt aagtcctccc tgacttttct gtggatgccg atttctgtaa 1260
actctgcatc cagagattca ttttctagat acaataaatt gctaatgttg ctggatcagg 1320
aagccgccag tacttgtcat atgtagcctt cacacagata gacctttttt tttttccaat 1380
tctatctttt gtttcctttt ttcccataag acaatgacat acgcttttaa tgaaaaggaa 1440
tcacgttaga ggaaaaatat ttattcatta tttgtcaaat tgtccggggt agttggcaga 1500
aatacagtct tccacaaaga aaattcctat aaggaagatt tggaagctct tcttcccagc 1560
actatgcttt ccttctttgg gatagagaat gttccagaca ttctcgcttc cctgaaagac 1620
tgaagaaagt gtagtgcatg ggacccacga aactgccctg gctccagtga aacttgggca 1680
catgctcagg ctactatagg tccagaagtc cttatgttaa gccctggcag gcaggtgttt 1740
attaaaattc tgaattttgg ggattttcaa aagataatat tttacataca ctgtatgtta 1800
tagaacttca tggatcagat ctggggcagc aacctataaa tcaacacctt aatatgctgc 1860
aacaaaatgt agaatattca gacaaaatgg atacataaag actaagtagc ccataagggg 1920
tcaaaatttg ctgccaaatg cgtatgccac caacttacaa aaacacttcg ttcgcagagc 1980
ttttcagatt gtggaatgtt ggataaggaa ttatagacct ctagtagctg aaatgcaaga 2040
ccccaagagg aagttcagat cttaatataa attcactttc atttttgata gctgtcccat 2100
ctggtcatgt ggttggcact agactggtgg caggggcttc tagctgactc gcacagggat 2160
tctcacaata gccgatatca gaatttgtgt tgaaggaact tgtctcttca tctaatatga 2220
tagcgggaaa aggagaggaa actactgcct ttagaaaata taagtaaagt gattaaagtg 2280
ctcacgttac cttgacacat agtttttcag tctatgggtt tagttacttt agatggcaag 2340
catgtaactt atattaatag taatttgtaa agttgggtgg ataagctatc cctgttgccg 2400
gttcatggat tacttctcta taaaaaatat atatttacca aaaaattttg tgacattcct 2460
tctcccatct cttccttgac atgcattgta aataggttct tcttgttctg agattcaata 2520
ttgaatttct cctatgctat tgacaataaa atattattga actacc 2566
<210>103
<211>2974
<212>DNA
<213>人类
<400>103
ctcagggcag agggaggaag gacagcagac cagacagtca cagcagcctt gacaaaacgt 60
tcctggaact caagctcttc tccacagagg aggacagagc agacagcaga gaccatggag 120
tctccctcgg cccctcccca cagatggtgc atcccctggc agaggctcct gctcacagcc 180
tcacttctaa ccttctggaa cccgcccacc actgccaagc tcactattga atccacgccg 240
ttcaatgtcg cagaggggaa ggaggtgctt ctacttgtcc acaatctgcc ccagcatctt 300
tttggctaca gctggtacaa aggtgaaaga gtggatggca accgtcaaat tataggatat 360
gtaataggaa ctcaacaagc taccccaggg cccgcataca gtggtcgaga gataatatac 420
cccaatgcat ccctgctgat ccagaacatc atccagaatg acacaggatt ctacacccta 480
cacgtcataa agtcagatct tgtgaatgaa gaagcaactg gccagttccg ggtatacccg 540
gagctgccca agccctccat ctccagcaac aactccaaac ccgtggagga caaggatgct 600
gtggccttca cctgtgaacc tgagactcag gacgcaacct acctgtggtg ggtaaacaat 660
cagagcctcc cggtcagtcc caggctgcag ctgtccaatg gcaacaggac cctcactcta 720
ttcaatgtca caagaaatga cacagcaagc tacaaatgtg aaacccagaa cccagtgagt 780
gccaggcgca gtgattcagt catcctgaat gtcctctatg gcccggatgc ccccaccatt 840
tcccctctaa acacatctta cagatcaggg gaaaatctga acctctcctg ccacgcagcc 900
tctaacccac ctgcacagta ctcttggttt gtcaatggga ctttccagca atccacccaa 960
gagctcttta tccccaacat cactgtgaat aatagtggat cctatacgtg ccaagcccat 1020
aactcagaca ctggcctcaa taggaccaca gtcacgacga tcacagtcta tgcagagcca 1080
cccaaaccct tcatcaccag caacaactcc aaccccgtgg aggatgagga tgctgtagcc 1140
ttaacctgtg aacctgagat tcagaacaca acctacctgt ggtgggtaaa taatcagagc 1200
ctcccggtca gtcccaggct gcagctgtcc aatgacaaca ggaccctcac tctactcagt 1260
gtcacaagga atgatgtagg accctatgag tgtggaatcc agaacgaatt aagtgttgac 1320
cacagcgacc cagtcatcct gaatgtcctc tatggcccag acgaccccac catttccccc 1380
tcatacacct attaccgtcc aggggtgaac ctcagcctct cctgccatgc agcctctaac 1440
ccacctgcac agtattcttg gctgattgat gggaacatcc agcaacacac acaagagctc 1500
tttatctcca acatcactga gaagaacagc ggactctata cctgccaggc caataactca 1560
gccagtggcc acagcaggac tacagtcaag acaatcacag tctctgcgga gctgcccaag 1620
ccctccatct ccagcaacaa ctccaaaccc gtggaggaca aggatgctgt ggccttcacc 1680
tgtgaacctg aggctcagaa cacaacctac ctgtggtggg taaatggtca gagcctccca 1740
gtcagtccca ggctgcagct gtccaatggc aacaggaccc tcactctatt caatgtcaca 1800
agaaatgacg caagagccta tgtatgtgga atccagaact cagtgagtgc aaaccgcagt 1860
gacccagtca ccctggatgt cctctatggg ccggacaccc ccatcatttc ccccccagac 1920
tcgtcttacc tttcgggagc gaacctcaac ctctcctgcc actcggcctc taacccatcc 1980
ccgcagtatt cttggcgtat caatgggata ccgcagcaac acacacaagt tctctttatc 2040
gccaaaatca cgccaaataa taacgggacc tatgcctgtt ttgtctctaa cttggctact 2100
ggccgcaata attccatagt caagagcatc acagtctctg catctggaac ttctcctggt 2160
ctctcagctg gggccactgt cggcatcatg attggagtgc tggttggggt tgctctgata 2220
tagcagccct ggtgtagttt cttcatttca ggaagactga cagttgtttt gcttcttcct 2280
taaagcattt gcaacagcta cagtctaaaa ttgcttcttt accaaggata tttacagaaa 2340
agactctgac cagagatcga gaccatccta gccaacatcg tgaaacccca tctctactaa 2400
aaatacaaaa atgagctggg cttggtggcg cgcacctgta gtcccagtta ctcgggaggc 2460
tgaggcagga gaatcgcttg aacccgggag gtggagattg cagtgagccc agatcgcacc 2520
actgcactcc agtctggcaa cagagcaaga ctccatctca aaaagaaaag aaaagaagac 2580
tctgacctgt actcttgaat acaagtttct gataccactg cactgtctga gaatttccaa 2640
aactttaatg aactaactga cagcttcatg aaactgtcca ccaagatcaa gcagagaaaa 2700
taattaattt catgggacta aatgaactaa tgaggattgc tgattcttta aatgtcttgt 2760
ttcccagatt tcaggaaact ttttttcttt taagctatcc actcttacag caatttgata 2820
aaatatactt ttgtgaacaa aaattgagac atttacattt tctccctatg tggtcgctcc 2880
agacttggga aactattcat gaatatttat attgtatggt aatatagtta ttgcacaagt 2940
tcaataaaaa tctgctcttt gtataacaga aaaa 2974
<210>104
<211>3069
<212>DNA
<213>人类
<400>104
tgtttccgct gcatccagac ttcctcaggc ggtggctgga ggctgcgcat ctggggcttt 60
aaacatacaa agggattgcc aggacctgcg gcggcggcgg cggcggcggg ggctggggcg 120
cgggggccgg accatgagcc gctgagccgg gcaaacccca ggccaccgag ccagcggacc 180
ctcggagcgc agccctgcgc cgcggaccag gctccaacca ggcggcgagg cggccacacg 240
caccgagcca gcgacccccg ggcgacgcgc ggggccaggg agcgctacga tggaggcgct 300
aatggcccgg ggcgcgctca cgggtcccct gagggcgctc tgtctcctgg gctgcctgct 360
gagccacgcc gccgccgcgc cgtcgcccat catcaagttc cccggcgatg tcgcccccaa 420
aacggacaaa gagttggcag tgcaatacct gaacaccttc tatggctgcc ccaaggagag 480
ctgcaacctg tttgtgctga aggacacact aaagaagatg cagaagttct ttggactgcc 540
ccagacaggt gatcttgacc agaataccat cgagaccatg cggaagccac gctgcggcaa 600
cccagatgtg gccaactaca acttcttccc tcgcaagccc aagtgggaca agaaccagat 660
cacatacagg atcattggct acacacctga tctggaccca gagacagtgg atgatgcctt 720
tgctcgtgcc ttccaagtct ggagcgatgt gaccccactg cggttttctc gaatccatga 780
tggagaggca gacatcatga tcaactttgg ccgctgggag catggcgatg gatacccctt 840
tgacggtaag gacggactcc tggctcatgc cttcgcccca ggcactggtg ttgggggaga 900
ctcccatttt gatgacgatg agctatggac cttgggagaa ggccaagtgg tccgtgtgaa 960
gtatggcaac gccgatgggg agtactgcaa gttccccttc ttgttcaatg gcaaggagta 1020
caacagctgc actgatactg gccgcagcga tggcttcctc tggtgctcca ccacctacaa 1080
ctttgagaag gatggcaagt acggcttctg tccccatgaa gccctgttca ccatgggcgg 1140
caacgctgaa ggacagccct gcaagtttcc attccgcttc cagggcacat cctatgacag 1200
ctgcaccact gagggccgca cggatggcta ccgctggtgc ggcaccactg aggactacga 1260
ccgcgacaag aagtatggct tctgccctga gaccgccatg tccactgttg gtgggaactc 1320
agaaggtgcc ccctgtgtct tccccttcac tttcctgggc aacaaatatg agagctgcac 1380
cagcgccggc cgcagtgacg gaaagatgtg gtgtgcgacc acagccaact acgatgacga 1440
ccgcaagtgg ggcttctgcc ctgaccaagg gtacagcctg ttcctcgtgg cagcccacga 1500
gtttggccac gccatggggc tggagcactc ccaagaccct ggggccctga tggcacccat 1560
ttacacctac accaagaact tccgtctgtc ccaggatgac atcaagggca ttcaggagct 1620
ctatggggcc tctcctgaca ttgaccttgg caccggcccc acccccacac tgggccctgt 1680
cactcctgag atctgcaaac aggacattgt atttgatggc atcgctcaga tccgtggtga 1740
gatcttcttc ttcaaggacc ggttcatttg gcggactgtg acgccacgtg acaagcccat 1800
ggggcccctg ctggtggcca cattctggcc tgagctcccg gaaaagattg atgcggtata 1860
cgaggcccca caggaggaga aggctgtgtt ctttgcaggg aatgaatact ggatctactc 1920
agccagcacc ctggagcgag ggtaccccaa gccactgacc agcctgggac tgccccctga 1980
tgtccagcga gtggatgccg cctttaactg gagcaaaaac aagaagacat acatctttgc 2040
tggagacaaa ttctggagat acaatgaggt gaagaagaaa atggatcctg gctttcccaa 2100
gctcatcgca gatgcctgga atgccatccc cgataacctg gatgccgtcg tggacctgca 2160
gggcggcggt cacagctact tcttcaaggg tgcctattac ctgaagctgg agaaccaaag 2220
tctgaagagc gtgaagtttg gaagcatcaa atccgactgg ctaggctgct gagctggccc 2280
tggctcccac aggcccttcc tctccactgc cttcgataca ccgggcctgg agaactagag 2340
aaggacccgg aggggcctgg cagccgtgcc ttcagctcta cagctaatca gcattctcac 2400
tcctacctgg taatttaaga ttccagagag tggctcctcc cggtgcccaa gaatagatgc 2460
tgactgtact cctcccaggc gccccttccc cctccaatcc caccaaccct cagagccacc 2520
cctaaagaga tcctttgata ttttcaacgc agccctgctt tgggctgccc tggtgctgcc 2580
acacttcagg ctcttctcct ttcacaacct tctgtggctc acagaaccct tggagccaat 2640
ggagactgtc tcaagagggc actggtggcc cgacagcctg gcacagggca gtgggacagg 2700
gcatggccag gtggccactc cagacccctg gcttttcact gctggctgcc ttagaacctt 2760
tcttacatta gcagtttgct ttgtatgcac tttgtttttt tctttgggtc ttgttttttt 2820
tttccactta gaaattgcat ttcctgacag aaggactcag gttgtctgaa gtcactgcac 2880
agtgcatctc agcccacata gtgatggttc ccctgttcac tctacttagc atgtccctac 2940
cgagtctctt ctccactgga tggaggaaaa ccaagccgtg gcttcccgct cagccctccc 3000
tgcccctccc ttcaaccatt ccccatggga aatgtcaaca agtatgaata aagacaccta 3060
ctgagtggc 3069
<210>105
<211>3299
<212>DNA
<213>人类
<400>105
cggagggagc gctgggagcg agcaagcgag cgtttggagc ccgggccagc agagggggcg 60
cccggtcgct gcctgtaccg ctcccgctgg tcatctccgc cgcgctcggg ggccccggga 120
ggagcgagac cgagtcggag agtccgggag ccaagccggg cgaaacccaa ctgcggagga 180
cgcccgcccc actcagcctc ctcctgcgtc cgagccgggg agcatcgccg agcgccccac 240
gggccggaga gctgggagca caggtcccgg cagccccagg gatggtctag gagccggcgt 300
aaggctcgct gctctgctcc ctgccggggc tagccgcctc ctgccgatcg cccggggctg 360
cgagctgcgg cggcccgggg ctgctcgccg ggcggcgcag gccggagaag ttagttgtgc 420
gcgcccttag tgcgcggaac cagccagcga gcgagggagc agcgaggcgc cgggaccatg 480
ggctggggga gccgctgctg ctgcccggga cgtttggacc tgctgtgcgt gctggcgctg 540
ctcgggggct gcctgctccc cgtgtgtcgg acgcgcgtct acaccaacca ctgggcagtc 600
aaaatcgccg ggggcttccc ggaggccaac cgtatcgcca gcaagtacgg attcatcaac 660
ataggacaga taggggccct gaaggactac taccacttct accatagcag gacgattaaa 720
aggtcagtta tctcgagcag agggacccac agtttcattt caatggaacc aaaggtggaa 780
tggatccaac agcaagtggt aaaaaagcgg acaaagaggg attatgactt cagtcgtgcc 840
cagtctacct atttcaatga tcccaagtgg cccagcatgt ggtatatgca ctgcagtgac 900
aatacacatc cctgccagtc tgacatgaat atcgaaggag cctggaagag aggctacacg 960
ggaaagaaca ttgtggtcac tatcctggat gacggaattg agagaaccca tccagatctg 1020
atgcaaaact acgatgctct ggcaagttgc gacgtgaatg ggaatgactt ggacccaatg 1080
cctcgttatg atgcaagcaa cgagaacaag catgggactc gctgtgctgg agaagtggca 1140
gccgctgcaa acaattcgca ctgcacagtc ggaattgctt tcaacgccaa gatcggagga 1200
gtgcgaatgc tggacggaga tgtcacggac atggttgaag caaaatcagt tagcttcaac 1260
ccccagcacg tgcacattta cagcgccagc tggggcccgg atgatgatgg caagactgtg 1320
gacggaccag cccccctcac ccggcaagcc tttgaaaacg gcgttagaat ggggcggaga 1380
ggcctcggct ctgtgtttgt ttgggcatct ggaaatggtg gaaggagcaa agaccactgc 1440
tcctgtgatg gctacaccaa cagcatctac accatctcca tcagcagcac tgcagaaagc 1500
ggaaagaaac cttggtacct ggaagagtgt tcatccacgc tggccacaac ctacagcagc 1560
ggggagtcct acgataagaa aatcatcact acagatctga ggcagcgttg cacggacaac 1620
cacactggga cgtcagcctc agcccccatg gctgcaggca tcattgcgct ggccctggaa 1680
gccaatccgt ttctgacctg gagagacgta cagcatgtta ttgtcaggac ttcccgtgcg 1740
ggacatttga acgctaatga ctggaaaacc aatgctgctg gttttaaggt gagccatctt 1800
tatggatttg gactgatgga cgcagaagcc atggtgatgg aggcagagaa gtggaccacc 1860
gttccccggc agcacgtgtg tgtggagagc acagaccgac aaatcaagac aatccgccct 1920
aacagtgcag tgcgctccat ctacaaagct tcaggctgct cggataaccc caaccgccat 1980
gtcaactacc tggagcacgt cgttgtgcgc atcaccatca cccaccccag gagaggagac 2040
ctggccatct acctgacctc gccctctgga actaggtctc agcttttggc caacaggcta 2100
tttgatcact ccatggaagg attcaaaaac tgggagttca tgaccattca ttgctgggga 2160
gaaagagctg ctggtgactg ggtccttgaa gtttatgata ctccctctca gctaaggaac 2220
tttaagactc caggtaaatt gaaagaatgg tctttggtcc tctacggcac ctccgtgcag 2280
ccatattcac caaccaatga atttccgaaa gtggaacggt tccgctatag ccgagttgaa 2340
gaccccacag acgactatgg cacagaggat tatgcaggtc cctgcgaccc tgagtgcagt 2400
gaggttggct gtgacgggcc aggaccagac cactgcaatg actgtttgca ctactactac 2460
aagctgaaaa acaataccag gatctgtgtc tccagctgcc cccctggcca ctaccacgcc 2520
gacaagaagc gctgcaggaa gtgtgccccc aactgtgagt cctgctttgg gagccatggt 2580
gaccaatgca tgtcctgcaa atatggatac tttctgaatg aagaaaccaa cagctgtgtt 2640
actcactgcc ctgatgggtc atatcaggat accaagaaaa atctttgccg gaaatgcagt 2700
gaaaactgca agacatgtac tgaattccat aactgtacag aatgtaggga tgggttaagc 2760
ctgcagggat cccggtgctc tgtctcctgt gaagatggac ggtatttcaa cggccaggac 2820
tgccagccct gccaccgctt ctgcgccact tgtgctgggg caggagctga tgggtgcatt 2880
aactgcacag agggctactt catggaggat gggagatgcg tgcagagctg tagtatcagc 2940
tattactttg accactcttc agagaatgga tacaaatcct gcaaaaaatg tgatatcagt 3000
tgtttgacgt gcaatggccc aggattcaag aactgtacaa gctgccctag tgggtatctc 3060
ttagacttag gaatgtgtca aatgggagcc atttgcaagg atgcaacgga agagtcctgg 3120
gcggaaggag gcttctgtat gcttgtgaaa aagaacaatc tgtgccaacg gaaggttctt 3180
caacaacttt gctgcaaaac atgtacattt caaggctgag cagccatctt agatttcttt 3240
gttcctgtag acttatagat tattccatat tattaaaaag aaaaaaaaaa gccaaaaag 3299
<210>106
<211>1664
<212>DNA
<213>人类
<400>106
atgggttgtg actgcttcgt ccaggaggtg ttctgctcag atgaggagct tgccaccgtc 60
ccgctggaca tcccgccata tacgaaaaac atcatctttg tggagacctc gttcaccaca 120
ttggaaacca gagcttttgg cagtaacccc aacttgacca aggtggtctt cctcaacact 180
cagctctgcc agtttaggcc ggatgccttt ggggggctgc ccaggctgga ggacctggag 240
gtcacaggca gtagcttctt gaacctcagc accaacatct tctccaacct gacctcgctg 300
ggcaagctca ccctcaactt caacatgctg gaggctctgc ccgagggtct tttccagcac 360
ctggctgccc tggagtccct ccacctgcag gggaaccagc tccaggccct gcccaggagg 420
ctcttccagc ctctgaccca tctgaagaca ctcaacctgg cccagaacct cctggcccag 480
ctcccggagg agctgttcca cccactcacc agcctgcaga ccctgaagct gagcaacaac 540
gcgctctctg gtctccccca gggtgtgttt ggcaaactgg gcagcctgca ggagctcttc 600
ctggacagca acaacatctc ggagctgccc cctcaggtgt tctcccagct cttctgccta 660
gagaggctgt ggctgcaacg caacgccatc acgcacctgc cgctctccat ctttgcctcc 720
ctgggtaatc tgacctttct gagcttgcag tggaacatgc ttcgggtcct gcctgccggc 780
ctctttgccc acaccccatg cctggttggc ctgtctctga cccataacca gctggagact 840
gtcgctgagg gcacctttgc ccacctgtcc aacctgcgtt ccctcatgct ctcatacaat 900
gccattaccc acctcccagc tggcatcttc agagacctgg aggagttggt caaactctac 960
ctgggcagca acaaccttac ggcgctgcac ccagccctct tccagaacct gtccaagctg 1020
gagctgctca gcctctccaa gaaccagctg accacacttc cggagggcat cttcgacacc 1080
aactacaacc tgttcaacct ggccctgcac ggtaacccct ggcagtgcga ctgccacctg 1140
gcctacctct tcaactggct gcagcagtac accgatcggc tcctgaacat ccagacctac 1200
tgcgctggcc ctgcctacct caaaggccag gtggtgcccg ccttgaatga gaagcagctg 1260
gtgtgtcccg tcacccggga ccacttgggc ttccaggtca cgtggccgga cgaaagcaag 1320
gcagggggca gctgggatct ggctgtgcag gaaagggcag cccggagcca gtgcacctac 1380
agcaaccccg agggcaccgt ggtgctcgcc tgtgaccagg cccagtgtcg ctggctgaac 1440
gtccagctct ctccttggca gggctccctg ggactgcagt acaatgctag tcaggagtgg 1500
gacctgaggt cgagctgcgg ttctctgcgg ctcaccgtgt ctatcgaggc tcgggcagca 1560
gggccctagt agcagcgcat acaggagctg gggaaggggg ctttggggcc tgcccacgcg 1620
acaggtaggg gcggagggga gctgagtctc cgaagcttgg cttt 1664
<210>107
<211>3383
<212>DNA
<213>人类
<400>107
cgggggccgc gcgggcaaga tggtgtgcgc tcgggcggcc ctcggtcccg gcgcgctctg 60
ggccgcggcc tggggcgtcc tgctgctcac agcccctgcg ggggcgcagc gtggccggaa 120
gaaggtcgtg cacgtgctgg agggtgagtc gggctcggta gtggtacaga cagcgcctgg 180
gcaggtggta agccaccgtg gtggcaccat cgtcttgccc tgccgctacc actatgaggc 240
agccgcccac ggtcacgacg gcgtccggct caagtggaca aaggtggtgg acccgctggc 300
cttcaccgac gtcttcgtgg cactaggccc ccagcaccgg gcattcggca gctaccgtgg 360
gcgggctgag ctgcagggcg acgggcctgg ggatgcctcc ctggtcctcc gcaacgtcac 420
gctgcaagac tacgggcgct atgagtgcga agtcaccaat gagctggaag atgacgctgg 480
catggtcaag ctggacctgg aaggcgtggt ctttccctac cacccccgtg gaggccgata 540
caagctgacc ttcgcggagg cgcagcgcgc gtgcgccgag caggacggca tcctggcatc 600
tgcagaacag ctgcacgcgg cctggcgcga cggcctggac tggtgcaacg cgggctggtt 660
gcgcgacggc tcagtgcaat accccgtgaa ccggccccgg gagccctgcg gcggcctggg 720
ggggaccggg agtgcagggg gcggcggtga tgccaacggg ggcctgcgca actacgggta 780
tcgccataac gccgaggaac gctacgacgc cttctgcttc acgtccaacc tgccggggcg 840
cgtgttcttc ctgaagccgc tgcgacctgt acccttctcc ggagctgcgc gcgcgtgtgc 900
tgcgcgtggc gcggccgtgg ccaaggtggg gcagctgttc gccgcgtgga agctgcagct 960
gctagaccgc tgcaccgcgg gttggctggc cgatggcagt gcgcgctacc ccatcgtgaa 1020
cccgcgagcg cgctgcggag gccgcaggcc tggtgtgcgc agcctcggct tcccggacgc 1080
cacccgacgg ctcttcggcg tctactgcta ccgcgctcca ggagcaccgg acccggcacc 1140
tggcggctgg ggctggggct gggcgggcgg cggcggctgg gcagggggcg cgcgcgatcc 1200
tgctgcctgg acccctctgc acgtctaggc tgggagtagg cggacagcca gggcgcttga 1260
ccactggtct agagccctgt ggtcccctgg agcctggcca cgcccttgaa gccctggaca 1320
ctggccacat tccctgtggt cccttacaaa ctaactgtgc ccctggggtc cctgaagact 1380
ggctagtcct ggcagaacag tactttggag ttccctggag cctggccagc cctcacctct 1440
tctggataga ggattccccc aactccccaa ctttctccat gagggtcacg ccccctgagg 1500
acctcaggag gccagcagaa cccgcaggct cctgaagact ggccacgcct cctgagacca 1560
cttggaaaca gaccaactgc ccccgtggtc gcctggtggc tggacccccg ggattgacta 1620
gagaccggcc gtacaccttc tgcatctcac tggagactga acactagtcc cttgcggtca 1680
cgtgggacac tgggcgcctc ctcctccccc tcctcctcac ctggagagac tacaggaact 1740
tcagggtcac tccccgtggt cacatggagg ttgtgggccg aggcgcttat tttcccttat 1800
ggtgacctga gtcctggaga ctcccattct ccccctctcc ctgagagtcc cctgcagttt 1860
ctgggtaaca gggcacaccc ctctagtttc atgggcgagc acccccatct gccacctcag 1920
actgacacac agccagctgg ctcacttact gggggccacg tcccacccct cagatatttc 1980
tttgaaggga gagcaaaccc accctgtcct ctgacgtccc tttcccaact gtcaccaaac 2040
agaccatctt cccaggcctg gggaccggta agatccatgt cactagttat gcagagcagt 2100
tgccttgggt cccactgtca ccaaggcaac cagtcctgct gctacctgtc acctagagtc 2160
acacacccct tccctcatca ggcacaccca tgaagacagt gcctccctcc tccagctgta 2220
accatggata ccacacattt ctcatctcat tggcccccac cccagagacc tccacctcaa 2280
cttctggctg tccctaccct gactcaccgc catggagatc accctccccg aagctgtcgc 2340
cagggtgacc caacatccag ttctccggct ctcaccatgg aaacaaactg tccctgtccc 2400
caggcccact ccagttccag accaccctcc atgctccacc cccaggcggt ttggacccca 2460
ccactgttgc catggtgacc aaactctgga gtccgaggta acagaacacc tgtcccccta 2520
ggcttttcct tgtggacaac ggggccctgt tcaccaagct gttgccatag agactgtcaa 2580
cgttgtcctc atgacaacca gacttccagt tctcaggaac ttctcattgt gggccagaag 2640
tcctgggtgc ctcctactag ggctacccta ctgcacccca tcaggggcct gatggctgcc 2700
ccttccccag acagggctgg acttctggag ctgctaagcc accctccgtt tgcacgttaa 2760
ctctatgccg gatagcagct gtgcacgaga caatcttgca acacccgggc atgtttgtcg 2820
tcgtcctaca aatgaggaaa ccgagcctat ggcgtgccct ggtctgttga gatatgcaag 2880
cactgagctc ctcttttgtc ctctgagacc ccatctccat tctcacccag ttcctctctc 2940
cttccctgac ccccacccac atttccctcc ttagagatcc aggagggatg gaatgttctt 3000
taaaattcaa cacccaccag gctctaagcg gcgatctgtg ctaagaggtc aggacccagc 3060
cgaagtcctc ggcgttgaca ggcagctggg gggacatgat ccatggacaa ggccatcccg 3120
gccgtgggag accccagtcc cgaagtcttg cctgcaggag tactggggtc cccctggggc 3180
cctctttact gtcacgtcat ctctaggaaa cctatctctg agttttggga ccaggtcggt 3240
ttgggtttga attctgcctc ttcttgctca ctgtgtgacc aagtgacaaa ctccttctga 3300
acctgtgttc tcccactgta ccagggctgt tctgtggtcc ccgtgagtgc caagcataca 3360
gtaggggctc aataaatcct tgt 3383
<210>108
<211>17
<212>PRT
<213>人类
<400>108
Phe Ala Ile Ser Glu Tyr Asn Lys Ala Thr Lys Asp Asp Tyr Tyr Arg
1 5 10 15
Arg
Claims (27)
1.用于检测胃癌的方法,其包括:
(a)准备生物学样品;和
(b)检测上述样品中GTM家族成员的过表达。
2.权利要求1的方法,其中所述GTM家族成员选自羧肽酶N,多肽2,83kDa链(CPN2)、基质金属蛋白酶12(MMP12)、抑制素(“INHBA”)、胰岛素样生长因子7(“IGFBP7”)、γ-谷氨酰水解酶(“GGH”)、富含亮氨酸脯氨酸的蛋白多糖(“LEPRE1”)、半胱氨酸蛋白酶抑制剂S(“CST4”)、分泌型frizzled相关蛋白4(“SFRP4”)、asporin(“ASPN”)、具有EF手型结构域1的细胞生长调节因子(“CGREF1”)、激肽释放酶10(KLK10)、金属蛋白酶组织抑制剂1(“TIMP1”)、富含半胱氨酸的分泌型酸性蛋白质(“SPARC”)、转化生长因子β诱导蛋白(“TGFBI”)、包含EGF的纤蛋白样细胞外基质蛋白质2(“EFEMP2”),光亮蛋白聚糖(“LUM”),stannin(“SNN”)、分泌型磷蛋白1(“SPP1”)、硫酸软骨素蛋白聚糖2(“CSPG2”)、N-酰基鞘氨醇酰胺水解酶(“ASAH1”)、丝氨酸蛋白酶11(“PRSS11”)、分泌型frizzled相关蛋白2(“SFRP2”)、XIIB组磷脂酶A2(“PLA2G12B”)、细胞外基质蛋白质spondin 2(“SPON2”)、嗅介蛋白1(“OLFM1”)、包含重复的血小板反应蛋白1(“TSRC1”)、血小板反应蛋白2(“THBS2”)、adlican、半胱氨酸蛋白酶抑制剂SA(“CST2”)、半胱氨酸蛋白酶抑制剂SN(“CST1”)、赖氨酰氧化酶样酶2(“LOXL2”)、甲状腺球蛋白(“TG”)、转化生长因子β1(“TGFB1”)、丝氨酸或半胱氨酸蛋白酶抑制剂进化枝H(“SERPINH1”)、丝氨酸或半胱氨酸蛋白酶抑制剂进化枝B(“SERPINB5”)、基质金属蛋白酶2(“MMP2”)、前蛋白转化酶枯草杆菌蛋白酶/kexin类型5(“PCSK5”)和透明质酸糖蛋白连接蛋白4(“HAPLN4”)。
3.权利要求1或2的方法,其中所述检测步骤通过检测GTM mRNA的过表达实现。
4.权利要求1或2的方法,其中所述检测步骤通过检测GTM cDNA的过表达实现。
5.权利要求4的方法,其中所述检测步骤使用与所述GMT cDNA的至少一部分互补的寡核苷酸实现。
6.权利要求4的方法,其中所述检测步骤使用利用正向引物和反向引物的qPCR方法实现。
7.权利要求1或2的方法,其中所述检测步骤通过检测GTM蛋白质的过表达实现。
8.权利要求1或2的方法,其中所述检测步骤通过检测GTM肽的过表达实现。
9.权利要求7或8的方法,其中所述检测步骤使用抗所述GTM的抗体实现。
10.权利要求7-9中任意一项的方法,其中所述检测步骤使用夹心型免疫测定法实现。
11.权利要求7-10中任意一项的方法,其中所述抗体是单克隆抗体。
12.权利要求7-10中任意一项的方法,其中所述抗体是多克隆抗血清。
13.检测GTM的装置,其包括:
在其上具有GTM捕获试剂的基质;和
与所述基质关联的检测器,所述检测器能够检测与所述捕获试剂有关的GTM。
14.权利要求13的装置,其中所述GTM捕获试剂是寡核苷酸。
15.权利要求13的装置,其中所述GTM捕获试剂是对GTM寡核苷酸、GTM蛋白质或者GTM肽特异性的抗体。
16.检测癌症的试剂盒,其包括:
在其上具有GTM捕获试剂的基质;
用于显现所述GTM捕获试剂和GTM的复合物的装置;
试剂;和
使用说明书。
17.权利要求16的试剂盒,其中所述GTM捕获试剂是GTM特异性寡核苷酸。
18.权利要求16的试剂盒,其中所述GTM捕获试剂是对GTM寡核苷酸、GTM蛋白质或者GTM肽具有选择性的GTM特异性抗体。
19.检测胃癌的方法,其包括步骤:
从怀疑患有胃癌的患者制备测试样品;
测定所述测试样品中GTM蛋白质的存在;和
将所述测试样品中存在的GTM数量与来自未患有胃癌的受试者的对照样品中的数值相比较。
20.筛选胃癌的方法,其包括步骤:
从测试受试者制备测试样品;
测定所述测试样品中GTM的存在;和
将所述测试样品中存在的GTM数量与来自未患有胃癌的受试者的对照样品中的数值相比较。
21.权利要求19的方法,其中所述GTM是GTM蛋白质或肽。
22.权利要求19的方法,其中所述GTM是对GTM特异性的寡核苷酸。
23.权利要求22的方法,其中所述寡核苷酸是DNA。
24.权利要求22的方法,其中所述寡核苷酸是RNA。
25.权利要求18-24中任意一项的方法,其中所述测定步骤使用ELISA测定法。
26.权利要求19-21中任意一项的方法,其中所述测试样品从血浆中获得。
27.权利要求19-21中任意一项的方法,其中所述测试样品从组织、尿液、胃液、血清和粪便中获得。
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