CN1689644A - 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 - Google Patents
包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 Download PDFInfo
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Abstract
Description
研究描述 | 适应症 | N* | ORR | CR | PR | DR中位值(月) | TIP中位值(月) | 参照值 |
I/II期,单一剂量的单一药剂 | 复发的B-细胞淋巴瘤 | 15 | 2(13%) | 0(0%) | 2(13%) | NA | 8.1 | 6 |
I/II期,多个不断变化的剂量 | 复发的低级,中级和高级淋巴瘤 | 34 | 17(50%) | 3(9%) | 14(41%) | 8.6 | 10.2 | 7 |
II期,与CHOP联合的多个剂量 | 新诊断的和复发的低级或滤泡B-细胞淋巴瘤 | 38 | 38(100%) | 22(58%) | 16(42%) | 35.3+ | 36.7+ | 21.22 |
III期,多个剂量的单一药剂 | 复发的低级或滤泡B-细胞淋巴瘤 | 151 | 76(50%) | 9(6%) | 67(44%) | 11.6 | 13.2 | 8,9 |
II期,多个剂量的单一药剂 | 复发的低级或滤泡B-细胞淋巴瘤 | 35 | 21(60%) | 5(14%) | 16(46%) | 13.4+ | 19.4+ | 13 |
II期,与干扰素联合的多个剂量 | 复发的低级或滤泡B-细胞淋巴瘤 | 38 | 17(45%) | 4(11%) | 13(34%) | 22.3+ | 25.2+ | 29 |
II期,多个剂量的单一药剂 | 复发的低级或滤泡B-细胞淋巴瘤,大体积淋巴瘤 | 28 | 12(43%) | 1(4%) | 11(39%) | 5.9 | 8.1 | 14 |
II期,多个剂量的单一药剂 | 复发的低级或滤泡B-细胞淋巴瘤,重新治疗 | 57 | 23(40%) | 6(11%) | 17(29%) | 15.0+ | 16.7+ | 19,20 |
II期,与CHOP物理疗法联合的多个剂量 | 以前未治疗的中级或高级淋巴瘤 | 30 | 29(96%) | 19(63%) | 10(33%) | 11+ | 17+ | 34 |
II期,其它类型的多个剂量 | 中级或高级B-细胞淋巴瘤 | 54 | 17(32%) | 5(9%) | 12(22%) | NA | 8.2+ | 33 |
Claims (31)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9618098P | 1998-08-11 | 1998-08-11 | |
US60/096,180 | 1998-08-11 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN99811514A Division CN1320044A (zh) | 1998-08-11 | 1999-08-11 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
Publications (2)
Publication Number | Publication Date |
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CN1689644A true CN1689644A (zh) | 2005-11-02 |
CN100531798C CN100531798C (zh) | 2009-08-26 |
Family
ID=22256115
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Application Number | Title | Priority Date | Filing Date |
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CNB2005100626872A Ceased CN100409898C (zh) | 1998-08-11 | 1999-08-11 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
CNB2005100626868A Ceased CN100531798C (zh) | 1998-08-11 | 1999-08-11 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
CN200910151382A Pending CN101695574A (zh) | 1998-08-11 | 1999-08-11 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
CNA2005100626887A Pending CN1689646A (zh) | 1998-08-11 | 1999-08-11 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
CN99811514A Pending CN1320044A (zh) | 1998-08-11 | 1999-08-11 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CNB2005100626872A Ceased CN100409898C (zh) | 1998-08-11 | 1999-08-11 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
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CN200910151382A Pending CN101695574A (zh) | 1998-08-11 | 1999-08-11 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
CNA2005100626887A Pending CN1689646A (zh) | 1998-08-11 | 1999-08-11 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
CN99811514A Pending CN1320044A (zh) | 1998-08-11 | 1999-08-11 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
Country Status (27)
Country | Link |
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US (13) | US6455043B1 (zh) |
EP (7) | EP1112084B2 (zh) |
JP (9) | JP2002522511A (zh) |
KR (5) | KR101155957B1 (zh) |
CN (5) | CN100409898C (zh) |
AT (1) | ATE414536T1 (zh) |
AU (3) | AU767965C (zh) |
BR (1) | BR9913645A (zh) |
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