KR20110022097A - B-세포 림프종을 치료하기 위한 항-cd20 항체를 포함하는 약제 - Google Patents
B-세포 림프종을 치료하기 위한 항-cd20 항체를 포함하는 약제 Download PDFInfo
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- KR20110022097A KR20110022097A KR1020117003784A KR20117003784A KR20110022097A KR 20110022097 A KR20110022097 A KR 20110022097A KR 1020117003784 A KR1020117003784 A KR 1020117003784A KR 20117003784 A KR20117003784 A KR 20117003784A KR 20110022097 A KR20110022097 A KR 20110022097A
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Abstract
Description
Claims (16)
- 항-CD20 항체를 포함하며, 화학요법제 이후에 유지 요법으로서 환자에 치료적 유효량으로 투여되는, 인간 환자에서 B 세포 림프종의 유지 요법으로서 사용하기 위한 제약 조성물.
- 제1항에 있어서, 화학요법제가 시클로포스파미드, 독소루비신, 빈크리스틴 및 프레드니손 (CHOP) 또는 시클로포스파미드, 빈크리스틴 및 프레드니손 (CVP)인 조성물.
- 제1항 또는 제2항에 있어서, 항-CD20 항체가 키메라 항-CD20 항체인 조성물.
- 제3항에 있어서, 키메라 항체가 리툭시맵(rituximab)인 조성물.
- 제1항 또는 제2항에 있어서, B-세포 림프종이 비-호지킨 림프종(NHL)인 조성물.
- 제4항에 있어서, 리툭시맵이 375 mg/m2의 용량으로 투여되는 것인 조성물.
- 리툭시맵을 포함하는, 인간 환자에서 저급 B 세포 비-호지킨 림프종을 치료하기 위한 제약 조성물로서, 여기서 환자는 시클로포스파미드, 빈크리스틴 및 프레드니손 (CVP) 요법 이후에 2년간의 리툭시맵 유지 요법으로 치료되고, 리툭시맵은 375 mg/m2 용량으로 투여되는 제약 조성물.
- 항-CD20 항체를 포함하는, 리툭시맵-난치성 B 세포 비-호지킨 림프종 치료용 제약 조성물.
- 제8항에 있어서, 항-CD20 항체가 방사성 동위원소 표지된 것인 조성물.
- 제9항에 있어서, 방사성 동위원소 표지가 이트륨-90 또는 요오드-131인 조성물.
- 제8항에 있어서, 항-CD20 항체가 인간 불변 영역 도메인을 포함하는 것인 조성물.
- 제11항에 있어서, 항체가 키메라 또는 인간화된 것인 조성물.
- 제8항에 있어서, 항체가 화학요법제와 조합된 것인 조성물.
- 제13항에 있어서, 화학요법제가 시클로포스파미드, 독소루비신, 빈크리스틴 및 프레드니손으로 구성된 군으로부터 선택된 하나 이상의 약제를 포함하는 것인 조성물.
- 제14항에 있어서, 화학요법제가 시클로포스파미드, 독소루비신, 빈크리스틴 및 프레드니손 (CHOP)을 포함하는 것인 조성물.
- 제8항에 있어서, 비-호지킨 림프종이 저급 또는 여포성 비-호지킨 림프종인 조성물.
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US9618098P | 1998-08-11 | 1998-08-11 | |
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PCT/US1999/018120 WO2000009160A1 (en) | 1998-08-11 | 1999-08-11 | Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody |
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KR1020097021865A Division KR101063278B1 (ko) | 1998-08-11 | 1999-08-11 | B-세포 림프종을 치료하기 위한 항-cd20 항체를 포함하는 약제 |
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KR1020087008471A KR20080038453A (ko) | 1998-08-11 | 1999-08-11 | B-세포 림프종을 치료하기 위한 항-cd20 항체를포함하는 약제 |
KR1020097001690A KR101023367B1 (ko) | 1998-08-11 | 1999-08-11 | B-세포 림프종을 치료하기 위한 항-cd20 항체를 포함하는 약제 |
KR1020117003784A KR101155957B1 (ko) | 1998-08-11 | 1999-08-11 | B-세포 림프종을 치료하기 위한 항-cd20 항체를 포함하는 약제 |
KR1020017001749A KR20010072388A (ko) | 1998-08-11 | 1999-08-11 | 항-cd20 항체의 투여를 포함하는 b-세포 림프종조합치료법 |
KR1020097021865A KR101063278B1 (ko) | 1998-08-11 | 1999-08-11 | B-세포 림프종을 치료하기 위한 항-cd20 항체를 포함하는 약제 |
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KR1020087008471A KR20080038453A (ko) | 1998-08-11 | 1999-08-11 | B-세포 림프종을 치료하기 위한 항-cd20 항체를포함하는 약제 |
KR1020097001690A KR101023367B1 (ko) | 1998-08-11 | 1999-08-11 | B-세포 림프종을 치료하기 위한 항-cd20 항체를 포함하는 약제 |
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KR1020097021865A KR101063278B1 (ko) | 1998-08-11 | 1999-08-11 | B-세포 림프종을 치료하기 위한 항-cd20 항체를 포함하는 약제 |
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