CN1326830C - 制备萘普生的硝基氧基衍生物的方法 - Google Patents

制备萘普生的硝基氧基衍生物的方法 Download PDF

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Publication number
CN1326830C
CN1326830C CNB038206056A CN03820605A CN1326830C CN 1326830 C CN1326830 C CN 1326830C CN B038206056 A CNB038206056 A CN B038206056A CN 03820605 A CN03820605 A CN 03820605A CN 1326830 C CN1326830 C CN 1326830C
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China
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compound
formula
branched
hydrogen
chain
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Expired - Fee Related
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CNB038206056A
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English (en)
Chinese (zh)
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CN1678560A (zh
Inventor
P·德尔索尔达托
G·桑图斯
F·贝内迪尼
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Nicox SA
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Nicox SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNB038206056A 2002-08-29 2003-08-06 制备萘普生的硝基氧基衍生物的方法 Expired - Fee Related CN1326830C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001861A ITMI20021861A1 (it) 2002-08-29 2002-08-29 Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI2002A001861 2002-08-29

Publications (2)

Publication Number Publication Date
CN1678560A CN1678560A (zh) 2005-10-05
CN1326830C true CN1326830C (zh) 2007-07-18

Family

ID=31972201

Family Applications (1)

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CNB038206056A Expired - Fee Related CN1326830C (zh) 2002-08-29 2003-08-06 制备萘普生的硝基氧基衍生物的方法

Country Status (20)

Country Link
US (3) US7199258B2 (enExample)
EP (2) EP1537070A1 (enExample)
JP (2) JP2005536559A (enExample)
KR (1) KR101100064B1 (enExample)
CN (1) CN1326830C (enExample)
AT (1) ATE449060T1 (enExample)
AU (2) AU2003266966B2 (enExample)
CA (1) CA2497187C (enExample)
CY (1) CY1109769T1 (enExample)
DE (1) DE60330152D1 (enExample)
DK (1) DK1532098T3 (enExample)
ES (1) ES2335656T3 (enExample)
IL (1) IL166587A0 (enExample)
IT (1) ITMI20021861A1 (enExample)
NZ (1) NZ537993A (enExample)
PT (1) PT1532098E (enExample)
RU (1) RU2315035C2 (enExample)
SI (1) SI1532098T1 (enExample)
WO (2) WO2004020384A1 (enExample)
ZA (1) ZA200500890B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101874014A (zh) * 2008-06-20 2010-10-27 尼科克斯公司 纯化(2s)-2-(6-甲氧基-2-萘基)丙酸4-(硝基氧基)丁酯的方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
AU2005308881B2 (en) * 2004-11-25 2010-10-28 Nicox S.A. Process for preparing halogenoalkylnitrates
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
US8062653B2 (en) * 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
CN101885684B (zh) * 2010-07-01 2013-10-30 南京中医药大学 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用
TWI417276B (zh) * 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
AU2019369157B2 (en) * 2018-10-25 2025-08-21 Dsm Ip Assets B.V. Aqueous compositions comprising omega nitrooxy-1-alkanols
CN111333560B (zh) * 2020-04-13 2024-01-23 合肥工业大学 一种制备螺环β-内酰胺的方法
CN112321420A (zh) * 2020-11-03 2021-02-05 浙江海翔川南药业有限公司 一种萘普生杂质及其制备方法

Citations (3)

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Publication number Priority date Publication date Assignee Title
JPS5279359A (en) * 1975-12-26 1977-07-04 Hitachi Ltd Cleaning material arrestor
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO2001010814A1 (en) * 1999-08-04 2001-02-15 Nicox S.A. Process for the preparation of naproxene nitroxyalkylesters

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US5057427A (en) * 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
JPH05279359A (ja) 1992-02-06 1993-10-26 Kawaken Fine Chem Co Ltd アポビンカミン酸エステルの製造方法
JPH05247015A (ja) * 1992-03-05 1993-09-24 Nippon Iyakuhin Kogyo Kk 新規ピペラジン誘導体
ATE184589T1 (de) 1994-05-10 1999-10-15 Nicox Sa Nitroverbindingen und ihre zubereitungen mit entzündungsremmenden, schmertzlindernden und antithrombotischen wirkungen
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
AU714258B2 (en) * 1996-08-16 1999-12-23 Handforth Investments Ltd. Non-ulcerogenic analgesic/antiinflammatory clonixin derivative
IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
FR2757159B1 (fr) * 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
US6429223B1 (en) * 2000-06-23 2002-08-06 Medinox, Inc. Modified forms of pharmacologically active agents and uses therefor
ITMI20010985A1 (it) * 2001-05-15 2002-11-15 Nicox Sa Farmaci per il morbo di alzheimer
ITMI20011308A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
US20050234123A1 (en) * 2001-11-27 2005-10-20 Aldo Belli Process
EP1539134A4 (en) * 2002-06-11 2007-04-11 Nitromed Inc SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE
US7163958B2 (en) * 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
US7199947B2 (en) * 2004-12-28 2007-04-03 Motorola Inc. Miniature digital camera lens

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5279359A (en) * 1975-12-26 1977-07-04 Hitachi Ltd Cleaning material arrestor
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO2001010814A1 (en) * 1999-08-04 2001-02-15 Nicox S.A. Process for the preparation of naproxene nitroxyalkylesters

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"A Stereoconvergent Strategy for the Synthesis ofEnantiomericaly Pure (R)-(-) and (S)-(+)-2-(6-Methoxy-2-Naphthyl)-Propanoic Acid (Naproxen)"C GIORDANO ET AL,TETRAHEDRON,Vol.45 No.13 1989 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101874014A (zh) * 2008-06-20 2010-10-27 尼科克斯公司 纯化(2s)-2-(6-甲氧基-2-萘基)丙酸4-(硝基氧基)丁酯的方法

Also Published As

Publication number Publication date
US20060173005A1 (en) 2006-08-03
US20070112194A1 (en) 2007-05-17
DE60330152D1 (de) 2009-12-31
EP1532098A1 (en) 2005-05-25
ZA200500890B (en) 2006-02-22
NZ537993A (en) 2006-11-30
IL166587A0 (en) 2006-01-15
ITMI20021861A1 (it) 2004-02-29
ES2335656T3 (es) 2010-03-31
PT1532098E (pt) 2010-02-04
AU2003266966A1 (en) 2004-03-19
CA2497187C (en) 2012-09-25
SI1532098T1 (sl) 2010-03-31
JP2005536558A (ja) 2005-12-02
US7199258B2 (en) 2007-04-03
AU2003266261A1 (en) 2004-03-19
US20100217028A1 (en) 2010-08-26
AU2003266966B2 (en) 2009-08-06
RU2005104419A (ru) 2005-11-20
ATE449060T1 (de) 2009-12-15
WO2004020384A1 (en) 2004-03-11
CY1109769T1 (el) 2014-09-10
EP1537070A1 (en) 2005-06-08
JP4528123B2 (ja) 2010-08-18
US7723382B2 (en) 2010-05-25
WO2004020385A1 (en) 2004-03-11
KR101100064B1 (ko) 2011-12-29
EP1532098B1 (en) 2009-11-18
JP2005536559A (ja) 2005-12-02
KR20050057057A (ko) 2005-06-16
RU2315035C2 (ru) 2008-01-20
CN1678560A (zh) 2005-10-05
CA2497187A1 (en) 2004-03-11
DK1532098T3 (da) 2010-03-15

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Granted publication date: 20070718

Termination date: 20130806