KR101100064B1 - 나프록센의 니트로옥시유도체 제조방법 - Google Patents

나프록센의 니트로옥시유도체 제조방법 Download PDF

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Publication number
KR101100064B1
KR101100064B1 KR1020057003509A KR20057003509A KR101100064B1 KR 101100064 B1 KR101100064 B1 KR 101100064B1 KR 1020057003509 A KR1020057003509 A KR 1020057003509A KR 20057003509 A KR20057003509 A KR 20057003509A KR 101100064 B1 KR101100064 B1 KR 101100064B1
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South Korea
Prior art keywords
compound
formula
reaction
hydrogen
naproxen
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KR1020057003509A
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English (en)
Korean (ko)
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KR20050057057A (ko
Inventor
솔다토 피에로 델
기안카를로 산투스
프란체스카 베네디니
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니콕스 에스. 에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020057003509A 2002-08-29 2003-08-06 나프록센의 니트로옥시유도체 제조방법 Expired - Fee Related KR101100064B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT001861A ITMI20021861A1 (it) 2002-08-29 2002-08-29 Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI2002A001861 2002-08-29
PCT/EP2003/008698 WO2004020384A1 (en) 2002-08-29 2003-08-06 Process for preparing nitrooxyderivatives of naproxen

Publications (2)

Publication Number Publication Date
KR20050057057A KR20050057057A (ko) 2005-06-16
KR101100064B1 true KR101100064B1 (ko) 2011-12-29

Family

ID=31972201

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057003509A Expired - Fee Related KR101100064B1 (ko) 2002-08-29 2003-08-06 나프록센의 니트로옥시유도체 제조방법

Country Status (20)

Country Link
US (3) US7723382B2 (enExample)
EP (2) EP1532098B1 (enExample)
JP (2) JP2005536559A (enExample)
KR (1) KR101100064B1 (enExample)
CN (1) CN1326830C (enExample)
AT (1) ATE449060T1 (enExample)
AU (2) AU2003266261A1 (enExample)
CA (1) CA2497187C (enExample)
CY (1) CY1109769T1 (enExample)
DE (1) DE60330152D1 (enExample)
DK (1) DK1532098T3 (enExample)
ES (1) ES2335656T3 (enExample)
IL (1) IL166587A0 (enExample)
IT (1) ITMI20021861A1 (enExample)
NZ (1) NZ537993A (enExample)
PT (1) PT1532098E (enExample)
RU (1) RU2315035C2 (enExample)
SI (1) SI1532098T1 (enExample)
WO (2) WO2004020385A1 (enExample)
ZA (1) ZA200500890B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004004648A2 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ATE434599T1 (de) 2004-11-25 2009-07-15 Nicox Sa Verfahren zur herstellung von halogenalkylnitraten
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
US8062653B2 (en) * 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
CN101885684B (zh) * 2010-07-01 2013-10-30 南京中医药大学 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用
TWI417276B (zh) * 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
MX2021004581A (es) * 2018-10-25 2021-06-15 Dsm Ip Assets Bv Composiciones acuosas que comprenden omega nitrooxi-1-alcanoles.
CN111333560B (zh) * 2020-04-13 2024-01-23 合肥工业大学 一种制备螺环β-内酰胺的方法
CN112321420A (zh) * 2020-11-03 2021-02-05 浙江海翔川南药业有限公司 一种萘普生杂质及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030641A1 (en) 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
WO2001010814A1 (en) 1999-08-04 2001-02-15 Nicox S.A. Process for the preparation of naproxene nitroxyalkylesters

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5279359A (en) * 1975-12-26 1977-07-04 Hitachi Ltd Cleaning material arrestor
US5057427A (en) * 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
JPH05279359A (ja) * 1992-02-06 1993-10-26 Kawaken Fine Chem Co Ltd アポビンカミン酸エステルの製造方法
JPH05247015A (ja) * 1992-03-05 1993-09-24 Nippon Iyakuhin Kogyo Kk 新規ピペラジン誘導体
SI0722434T1 (en) * 1993-10-06 1998-12-31 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
WO1998007701A1 (en) * 1996-08-16 1998-02-26 Handforth Investments Ltd. Non-ulcerogenic analgesic/anti-inflammatory clonixin derivative
IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
US6429223B1 (en) * 2000-06-23 2002-08-06 Medinox, Inc. Modified forms of pharmacologically active agents and uses therefor
ITMI20010985A1 (it) * 2001-05-15 2002-11-15 Nicox Sa Farmaci per il morbo di alzheimer
ITMI20011308A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
WO2003045896A1 (en) * 2001-11-27 2003-06-05 Astrazeneca Ab New process
US7220749B2 (en) * 2002-06-11 2007-05-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2004004648A2 (en) * 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
US7199947B2 (en) * 2004-12-28 2007-04-03 Motorola Inc. Miniature digital camera lens

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030641A1 (en) 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
WO2001010814A1 (en) 1999-08-04 2001-02-15 Nicox S.A. Process for the preparation of naproxene nitroxyalkylesters

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.Med.Chem., 1993, Vol.36, pp.815-819

Also Published As

Publication number Publication date
NZ537993A (en) 2006-11-30
CY1109769T1 (el) 2014-09-10
DK1532098T3 (da) 2010-03-15
RU2315035C2 (ru) 2008-01-20
US20070112194A1 (en) 2007-05-17
JP4528123B2 (ja) 2010-08-18
DE60330152D1 (de) 2009-12-31
EP1532098A1 (en) 2005-05-25
KR20050057057A (ko) 2005-06-16
AU2003266966B2 (en) 2009-08-06
IL166587A0 (en) 2006-01-15
ZA200500890B (en) 2006-02-22
AU2003266261A1 (en) 2004-03-19
WO2004020384A1 (en) 2004-03-11
EP1537070A1 (en) 2005-06-08
EP1532098B1 (en) 2009-11-18
AU2003266966A1 (en) 2004-03-19
SI1532098T1 (sl) 2010-03-31
JP2005536558A (ja) 2005-12-02
PT1532098E (pt) 2010-02-04
WO2004020385A1 (en) 2004-03-11
US20060173005A1 (en) 2006-08-03
RU2005104419A (ru) 2005-11-20
US20100217028A1 (en) 2010-08-26
JP2005536559A (ja) 2005-12-02
CA2497187A1 (en) 2004-03-11
US7723382B2 (en) 2010-05-25
CN1326830C (zh) 2007-07-18
ES2335656T3 (es) 2010-03-31
ATE449060T1 (de) 2009-12-15
US7199258B2 (en) 2007-04-03
CA2497187C (en) 2012-09-25
ITMI20021861A1 (it) 2004-02-29
CN1678560A (zh) 2005-10-05

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