KR101100064B1 - 나프록센의 니트로옥시유도체 제조방법 - Google Patents

나프록센의 니트로옥시유도체 제조방법 Download PDF

Info

Publication number
KR101100064B1
KR101100064B1 KR1020057003509A KR20057003509A KR101100064B1 KR 101100064 B1 KR101100064 B1 KR 101100064B1 KR 1020057003509 A KR1020057003509 A KR 1020057003509A KR 20057003509 A KR20057003509 A KR 20057003509A KR 101100064 B1 KR101100064 B1 KR 101100064B1
Authority
KR
South Korea
Prior art keywords
compound
formula
reaction
hydrogen
naproxen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020057003509A
Other languages
English (en)
Korean (ko)
Other versions
KR20050057057A (ko
Inventor
솔다토 피에로 델
기안카를로 산투스
프란체스카 베네디니
Original Assignee
니콕스 에스. 에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 니콕스 에스. 에이. filed Critical 니콕스 에스. 에이.
Publication of KR20050057057A publication Critical patent/KR20050057057A/ko
Application granted granted Critical
Publication of KR101100064B1 publication Critical patent/KR101100064B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020057003509A 2002-08-29 2003-08-06 나프록센의 니트로옥시유도체 제조방법 Expired - Fee Related KR101100064B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2002A001861 2002-08-29
IT001861A ITMI20021861A1 (it) 2002-08-29 2002-08-29 Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
PCT/EP2003/008698 WO2004020384A1 (en) 2002-08-29 2003-08-06 Process for preparing nitrooxyderivatives of naproxen

Publications (2)

Publication Number Publication Date
KR20050057057A KR20050057057A (ko) 2005-06-16
KR101100064B1 true KR101100064B1 (ko) 2011-12-29

Family

ID=31972201

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057003509A Expired - Fee Related KR101100064B1 (ko) 2002-08-29 2003-08-06 나프록센의 니트로옥시유도체 제조방법

Country Status (20)

Country Link
US (3) US7723382B2 (enExample)
EP (2) EP1537070A1 (enExample)
JP (2) JP4528123B2 (enExample)
KR (1) KR101100064B1 (enExample)
CN (1) CN1326830C (enExample)
AT (1) ATE449060T1 (enExample)
AU (2) AU2003266261A1 (enExample)
CA (1) CA2497187C (enExample)
CY (1) CY1109769T1 (enExample)
DE (1) DE60330152D1 (enExample)
DK (1) DK1532098T3 (enExample)
ES (1) ES2335656T3 (enExample)
IL (1) IL166587A0 (enExample)
IT (1) ITMI20021861A1 (enExample)
NZ (1) NZ537993A (enExample)
PT (1) PT1532098E (enExample)
RU (1) RU2315035C2 (enExample)
SI (1) SI1532098T1 (enExample)
WO (2) WO2004020384A1 (enExample)
ZA (1) ZA200500890B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005539089A (ja) 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
AU2005308881B2 (en) 2004-11-25 2010-10-28 Nicox S.A. Process for preparing halogenoalkylnitrates
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
US8062653B2 (en) * 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
CN101885684B (zh) * 2010-07-01 2013-10-30 南京中医药大学 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用
TWI417276B (zh) * 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents
EP3869972A1 (en) * 2018-10-25 2021-09-01 DSM IP Assets B.V. Aqueous compositions comprising omega nitrooxy-1-alkanols
CN111333560B (zh) * 2020-04-13 2024-01-23 合肥工业大学 一种制备螺环β-内酰胺的方法
CN112321420A (zh) * 2020-11-03 2021-02-05 浙江海翔川南药业有限公司 一种萘普生杂质及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030641A1 (en) 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
WO2001010814A1 (en) 1999-08-04 2001-02-15 Nicox S.A. Process for the preparation of naproxene nitroxyalkylesters

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5279359A (en) * 1975-12-26 1977-07-04 Hitachi Ltd Cleaning material arrestor
US5057427A (en) * 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
JPH05279359A (ja) * 1992-02-06 1993-10-26 Kawaken Fine Chem Co Ltd アポビンカミン酸エステルの製造方法
JPH05247015A (ja) * 1992-03-05 1993-09-24 Nippon Iyakuhin Kogyo Kk 新規ピペラジン誘導体
JP3775796B2 (ja) * 1993-10-06 2006-05-17 ニコックス エス エイ 抗炎症活性及び／又は鎮痛活性を有する硝酸エステル類及びそれらの製造方法
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
JP2000516235A (ja) 1996-08-16 2000-12-05 ハンドフォース インベストメンツ リミテッド 非潰瘍誘発性の鎮痛／抗炎症クロニキシン誘導体
IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
FR2757159B1 (fr) * 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
US6429223B1 (en) * 2000-06-23 2002-08-06 Medinox, Inc. Modified forms of pharmacologically active agents and uses therefor
ITMI20010985A1 (it) * 2001-05-15 2002-11-15 Nicox Sa Farmaci per il morbo di alzheimer
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20011308A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
WO2003045896A1 (en) * 2001-11-27 2003-06-05 Astrazeneca Ab New process
US7220749B2 (en) * 2002-06-11 2007-05-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2005539089A (ja) * 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
US7199947B2 (en) * 2004-12-28 2007-04-03 Motorola Inc. Miniature digital camera lens

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030641A1 (en) 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
WO2001010814A1 (en) 1999-08-04 2001-02-15 Nicox S.A. Process for the preparation of naproxene nitroxyalkylesters

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.Med.Chem., 1993, Vol.36, pp.815-819

Also Published As

Publication number Publication date
JP4528123B2 (ja) 2010-08-18
RU2315035C2 (ru) 2008-01-20
EP1532098B1 (en) 2009-11-18
AU2003266261A1 (en) 2004-03-19
EP1537070A1 (en) 2005-06-08
US20060173005A1 (en) 2006-08-03
CN1678560A (zh) 2005-10-05
CY1109769T1 (el) 2014-09-10
KR20050057057A (ko) 2005-06-16
JP2005536558A (ja) 2005-12-02
ITMI20021861A1 (it) 2004-02-29
US20070112194A1 (en) 2007-05-17
RU2005104419A (ru) 2005-11-20
CN1326830C (zh) 2007-07-18
WO2004020384A1 (en) 2004-03-11
ES2335656T3 (es) 2010-03-31
ZA200500890B (en) 2006-02-22
IL166587A0 (en) 2006-01-15
NZ537993A (en) 2006-11-30
JP2005536559A (ja) 2005-12-02
CA2497187C (en) 2012-09-25
SI1532098T1 (sl) 2010-03-31
US7199258B2 (en) 2007-04-03
WO2004020385A1 (en) 2004-03-11
PT1532098E (pt) 2010-02-04
AU2003266966B2 (en) 2009-08-06
DE60330152D1 (de) 2009-12-31
EP1532098A1 (en) 2005-05-25
US20100217028A1 (en) 2010-08-26
AU2003266966A1 (en) 2004-03-19
US7723382B2 (en) 2010-05-25
ATE449060T1 (de) 2009-12-15
DK1532098T3 (da) 2010-03-15
CA2497187A1 (en) 2004-03-11

Similar Documents

Publication Publication Date Title
US6013828A (en) Processes and intermediates useful to make antifolates
US6262262B1 (en) Processes and intermediates useful to make antifolates
JP4528123B2 (ja) ナプロキセンのニトロオキシ誘導体の製造法
US6696591B1 (en) Process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives
EP0905128B1 (en) Processes and intermediates useful to make antifolates
JPS6087251A (ja) 置換ベンズアミド誘導体の製造法
US4009172A (en) 2,3,3A,6,7,7A-Hexahydro-thieno[3,2-b]pyridin-(4H)5-ones
US6090168A (en) Processes and intermediates useful to make antifolates
EP0183797B1 (en) 5-halo-4h-1,3-dioxin-4-one compounds, process for their preparation and their use in the preparation of alpha-halo-acetoacetic esters
HU203316B (en) Process for producing mercapto-benzoic acid derivatives
KR0179320B1 (ko) (±)-2-(톨릴술피닐)-시클로펜타데칸-1-온 및 그의 제법
JP4686466B2 (ja) 環状Ｎ−置換α−イミノカルボン酸の製法
JPH0656821A (ja) （ハロアルキル）ジベンゾテルロフェニウム塩、その製造中間体、及びそれらの製造方法
KR100201582B1 (ko) 제초성 피리미딜옥시벤조산 옥심에스테르 유도체의제조방법
JP2006176531A (ja) 光学活性ベンズイミダゾール誘導体の光学異性体
JP2558491B2 (ja) α，βー不飽和カルボニル化合物のオルガノチオメチル化方法
JPH0316339B2 (enExample)
JPH0482144B2 (enExample)
KR19990027763A (ko) ο-(클로로메틸)벤조산 에스테르 유도체의 제조방법
KR20050056157A (ko) 광학적으로 순수한 펜에틸 아민 유도체의 제조방법
JPH0316338B2 (enExample)
HK1020437B (en) Processes and intermediates useful to make antifolates
JPH03123769A (ja) ビスメチルスルホノキシメチルエーテルの製造方法
JPH0569106B2 (enExample)

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20141223

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20141223