IL166587A0 - Process for preparing nitrooxyderivatives of napr oxen - Google Patents
Process for preparing nitrooxyderivatives of napr oxenInfo
- Publication number
- IL166587A0 IL166587A0 IL16658705A IL16658705A IL166587A0 IL 166587 A0 IL166587 A0 IL 166587A0 IL 16658705 A IL16658705 A IL 16658705A IL 16658705 A IL16658705 A IL 16658705A IL 166587 A0 IL166587 A0 IL 166587A0
- Authority
- IL
- Israel
- Prior art keywords
- preparing
- nitrooxyderivatives
- napr
- oxen
- compound
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical class C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 101150020251 NR13 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001861A ITMI20021861A1 (it) | 2002-08-29 | 2002-08-29 | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
| PCT/EP2003/008698 WO2004020384A1 (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyderivatives of naproxen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL166587A0 true IL166587A0 (en) | 2006-01-15 |
Family
ID=31972201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16658705A IL166587A0 (en) | 2002-08-29 | 2005-01-31 | Process for preparing nitrooxyderivatives of napr oxen |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7723382B2 (enExample) |
| EP (2) | EP1537070A1 (enExample) |
| JP (2) | JP4528123B2 (enExample) |
| KR (1) | KR101100064B1 (enExample) |
| CN (1) | CN1326830C (enExample) |
| AT (1) | ATE449060T1 (enExample) |
| AU (2) | AU2003266261A1 (enExample) |
| CA (1) | CA2497187C (enExample) |
| CY (1) | CY1109769T1 (enExample) |
| DE (1) | DE60330152D1 (enExample) |
| DK (1) | DK1532098T3 (enExample) |
| ES (1) | ES2335656T3 (enExample) |
| IL (1) | IL166587A0 (enExample) |
| IT (1) | ITMI20021861A1 (enExample) |
| NZ (1) | NZ537993A (enExample) |
| PT (1) | PT1532098E (enExample) |
| RU (1) | RU2315035C2 (enExample) |
| SI (1) | SI1532098T1 (enExample) |
| WO (2) | WO2004020384A1 (enExample) |
| ZA (1) | ZA200500890B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1539729A4 (en) | 2002-07-03 | 2008-02-20 | Nitromed Inc | NITROSED NON-TESTED OXIDE COMPOUNDS, COMPOSITIONS, AND APPLICATION METHODS |
| ITMI20021861A1 (it) * | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
| MX2007006235A (es) * | 2004-11-25 | 2007-07-20 | Nicox Sa | Procedimiento para la preparacion de halogenoalquilnitratos. |
| WO2009149053A2 (en) * | 2008-06-02 | 2009-12-10 | Dr. Reddy's Laboratories Ltd. | Naproxcinod process and solid dispersion |
| ITRM20080325A1 (it) * | 2008-06-20 | 2009-12-21 | Nicox Sa | Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato |
| US8062653B2 (en) | 2009-02-18 | 2011-11-22 | Bezwada Biomedical, Llc | Controlled release of nitric oxide and drugs from functionalized macromers and oligomers |
| CN101885684B (zh) * | 2010-07-01 | 2013-10-30 | 南京中医药大学 | 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用 |
| TWI417276B (zh) * | 2011-03-01 | 2013-12-01 | Everlight Chem Ind Corp | ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途 |
| CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
| AU2019369157B2 (en) * | 2018-10-25 | 2025-08-21 | Dsm Ip Assets B.V. | Aqueous compositions comprising omega nitrooxy-1-alkanols |
| CN111333560B (zh) * | 2020-04-13 | 2024-01-23 | 合肥工业大学 | 一种制备螺环β-内酰胺的方法 |
| CN112321420A (zh) * | 2020-11-03 | 2021-02-05 | 浙江海翔川南药业有限公司 | 一种萘普生杂质及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5279359A (en) * | 1975-12-26 | 1977-07-04 | Hitachi Ltd | Cleaning material arrestor |
| US5057427A (en) * | 1988-04-07 | 1991-10-15 | Sepracor, Inc. | Method for resolution of stereoisomers |
| JPH05279359A (ja) * | 1992-02-06 | 1993-10-26 | Kawaken Fine Chem Co Ltd | アポビンカミン酸エステルの製造方法 |
| JPH05247015A (ja) * | 1992-03-05 | 1993-09-24 | Nippon Iyakuhin Kogyo Kk | 新規ピペラジン誘導体 |
| US5700947A (en) * | 1993-10-06 | 1997-12-23 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
| WO1995030641A1 (en) * | 1994-05-10 | 1995-11-16 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
| IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
| CA2262788A1 (en) * | 1996-08-16 | 1998-02-26 | Gustavo Enrique Aldoma | Non-ulcerogenic analgesic/anti-inflammatory clonixin derivative |
| IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| FR2757159B1 (fr) * | 1996-12-12 | 1999-12-17 | Hoechst Marion Roussel Inc | Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1313596B1 (it) * | 1999-08-04 | 2002-09-09 | Nicox Sa | Processo per la preparazione di nitrossialchil esteri del naproxene |
| IT1314184B1 (it) * | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| US6429223B1 (en) * | 2000-06-23 | 2002-08-06 | Medinox, Inc. | Modified forms of pharmacologically active agents and uses therefor |
| ITMI20010985A1 (it) * | 2001-05-15 | 2002-11-15 | Nicox Sa | Farmaci per il morbo di alzheimer |
| ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
| ITMI20011308A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per il dolore cronico |
| WO2003045896A1 (en) * | 2001-11-27 | 2003-06-05 | Astrazeneca Ab | New process |
| CA2487414A1 (en) * | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| EP1539729A4 (en) * | 2002-07-03 | 2008-02-20 | Nitromed Inc | NITROSED NON-TESTED OXIDE COMPOUNDS, COMPOSITIONS, AND APPLICATION METHODS |
| ITMI20021861A1 (it) * | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
| US7199947B2 (en) * | 2004-12-28 | 2007-04-03 | Motorola Inc. | Miniature digital camera lens |
-
2002
- 2002-08-29 IT IT001861A patent/ITMI20021861A1/it unknown
-
2003
- 2003-08-06 PT PT03747879T patent/PT1532098E/pt unknown
- 2003-08-06 DE DE60330152T patent/DE60330152D1/de not_active Expired - Lifetime
- 2003-08-06 US US10/522,986 patent/US7723382B2/en not_active Expired - Fee Related
- 2003-08-06 EP EP03790866A patent/EP1537070A1/en not_active Withdrawn
- 2003-08-06 SI SI200331743T patent/SI1532098T1/sl unknown
- 2003-08-06 RU RU2005104419/04A patent/RU2315035C2/ru not_active IP Right Cessation
- 2003-08-06 AU AU2003266261A patent/AU2003266261A1/en not_active Abandoned
- 2003-08-06 CN CNB038206056A patent/CN1326830C/zh not_active Expired - Fee Related
- 2003-08-06 NZ NZ537993A patent/NZ537993A/en not_active IP Right Cessation
- 2003-08-06 AU AU2003266966A patent/AU2003266966B2/en not_active Ceased
- 2003-08-06 DK DK03747879.9T patent/DK1532098T3/da active
- 2003-08-06 JP JP2004532054A patent/JP4528123B2/ja not_active Expired - Fee Related
- 2003-08-06 US US10/523,722 patent/US7199258B2/en not_active Expired - Fee Related
- 2003-08-06 AT AT03747879T patent/ATE449060T1/de active
- 2003-08-06 WO PCT/EP2003/008698 patent/WO2004020384A1/en not_active Ceased
- 2003-08-06 ES ES03747879T patent/ES2335656T3/es not_active Expired - Lifetime
- 2003-08-06 KR KR1020057003509A patent/KR101100064B1/ko not_active Expired - Fee Related
- 2003-08-06 CA CA2497187A patent/CA2497187C/en not_active Expired - Fee Related
- 2003-08-06 EP EP03747879A patent/EP1532098B1/en not_active Expired - Lifetime
- 2003-08-06 WO PCT/EP2003/008700 patent/WO2004020385A1/en not_active Ceased
- 2003-08-06 JP JP2004532055A patent/JP2005536559A/ja not_active Ceased
-
2005
- 2005-01-31 ZA ZA200500890A patent/ZA200500890B/xx unknown
- 2005-01-31 IL IL16658705A patent/IL166587A0/xx not_active IP Right Cessation
-
2010
- 2010-02-10 CY CY20101100132T patent/CY1109769T1/el unknown
- 2010-03-30 US US12/750,381 patent/US20100217028A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |