CN108112254B - 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 - Google Patents

抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 Download PDF

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CN108112254B
CN108112254B CN201680027483.1A CN201680027483A CN108112254B CN 108112254 B CN108112254 B CN 108112254B CN 201680027483 A CN201680027483 A CN 201680027483A CN 108112254 B CN108112254 B CN 108112254B
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antibody
seq
certain embodiments
acid sequence
activatable
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CN108112254A (zh
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J.W.韦斯特
L.梅
S.J.摩尔
M.阮
D.霍斯特特
O.瓦西尔耶瓦
J.萨格特
J.特雷特
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Cytomx Therapeutics Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/55—Fab or Fab'
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Peptides Or Proteins (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201680027483.1A 2015-03-13 2016-03-14 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 Active CN108112254B (zh)

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US201562133231P 2015-03-13 2015-03-13
US62/133231 2015-03-13
US201562139596P 2015-03-27 2015-03-27
US62/139596 2015-03-27
US201562218883P 2015-09-15 2015-09-15
US62/218883 2015-09-15
PCT/US2016/022345 WO2016149201A2 (en) 2015-03-13 2016-03-14 Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof

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US (4) US10336824B2 (https=)
EP (1) EP3268392A2 (https=)
JP (3) JP6826055B2 (https=)
KR (1) KR20170135860A (https=)
CN (2) CN108112254B (https=)
AU (2) AU2016233495B2 (https=)
BR (1) BR112017019559B1 (https=)
CA (1) CA2978942A1 (https=)
IL (2) IL292449B2 (https=)
MA (1) MA42971A (https=)
MX (2) MX2017011644A (https=)
MY (1) MY194225A (https=)
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