SG11201808626WA - Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors - Google Patents

Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors

Info

Publication number
SG11201808626WA
SG11201808626WA SG11201808626WA SG11201808626WA SG11201808626WA SG 11201808626W A SG11201808626W A SG 11201808626WA SG 11201808626W A SG11201808626W A SG 11201808626WA SG 11201808626W A SG11201808626W A SG 11201808626WA SG 11201808626W A SG11201808626W A SG 11201808626WA
Authority
SG
Singapore
Prior art keywords
inhibitors
administering
combination
tumor burden
reducing tumor
Prior art date
Application number
SG11201808626WA
Inventor
Israel Charo
Heiyoun Jung
Thomas Schall
Penglie Zhang
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of SG11201808626WA publication Critical patent/SG11201808626WA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201808626WA 2016-04-07 2017-04-06 Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors SG11201808626WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662319689P 2016-04-07 2016-04-07
PCT/US2017/026290 WO2017176965A1 (en) 2016-04-07 2017-04-06 Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors

Publications (1)

Publication Number Publication Date
SG11201808626WA true SG11201808626WA (en) 2018-10-30

Family

ID=59999231

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201808626WA SG11201808626WA (en) 2016-04-07 2017-04-06 Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors

Country Status (20)

Country Link
US (2) US10568870B2 (en)
EP (1) EP3439653B1 (en)
JP (2) JP2019510832A (en)
KR (1) KR102370704B1 (en)
CN (1) CN109310677A (en)
AR (1) AR108202A1 (en)
AU (1) AU2017246460B2 (en)
BR (1) BR112018070361A2 (en)
CA (1) CA3019391A1 (en)
DK (1) DK3439653T3 (en)
ES (1) ES2864148T3 (en)
IL (1) IL261998B2 (en)
MX (1) MX2018012132A (en)
PL (1) PL3439653T3 (en)
PT (1) PT3439653T (en)
RU (1) RU2745195C2 (en)
SG (1) SG11201808626WA (en)
TW (1) TWI808938B (en)
WO (1) WO2017176965A1 (en)
ZA (1) ZA201806633B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2893597C (en) 2012-12-07 2021-06-29 Chemocentryx, Inc. Diazole lactams
BR112017019559B1 (en) 2015-03-13 2020-08-04 Cytomx Therapeutics, Inc ANTI-PDL1 ANTIBODIES, ACTIVABLE ANTI-PDL1 ANTIBODIES, AND METHODS OF USE OF THESE
US10513558B2 (en) 2015-07-13 2019-12-24 Cytomx Therapeutics, Inc. Anti-PD1 antibodies, activatable anti-PD1 antibodies, and methods of use thereof
PT3439653T (en) 2016-04-07 2021-03-25 Chemocentryx Inc Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors
CA3029256A1 (en) 2016-06-27 2018-01-04 Chemocentryx, Inc. Immunomodulator compounds
HUE054316T2 (en) * 2017-03-29 2021-08-30 Shionogi & Co Pharmaceutical composition for cancer treatment
KR20200016899A (en) 2017-06-01 2020-02-17 싸이톰스 테라퓨틱스, 인크. Activatable anti-PDL1 antibody, and methods of using the same
IL272258B (en) 2017-07-28 2022-08-01 Chemocentryx Inc Immunomodulator compounds
MA49859A (en) 2017-08-08 2021-04-07 Chemocentryx Inc MACROCYCLIC IMMUNOMODULATORS
CN111511397A (en) * 2017-12-22 2020-08-07 科达金尼克斯有限公司 Recombinant viruses with codon pair de-optimized regions and their use for treating cancer
MA51232A (en) 2018-02-22 2020-10-07 Chemocentryx Inc INDANE-AMINES USEFUL AS PD-L1 ANTAGONISTS
JP7329860B2 (en) * 2018-06-15 2023-08-21 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム Method for treating and preventing breast cancer using S-equol
EP3843711A4 (en) * 2018-08-29 2022-08-03 ChemoCentryx, Inc. Methods of treating cancer with small molecule pd-l1 inhibitors
TW202024638A (en) * 2018-09-04 2020-07-01 美商泰沙羅公司 Methods of treating cancer
US20220177587A1 (en) 2018-09-19 2022-06-09 Alpine Immune Sciences, Inc. Methods and uses of variant cd80 fusion proteins and related constructs
KR20200043618A (en) * 2018-10-18 2020-04-28 주식회사유한양행 Pharmaceutical composition for oral administration comprising an aminopyrimidine derivative or its salt
FI3880186T3 (en) 2018-11-14 2024-05-30 Regeneron Pharma Intralesional administration of pd-1 inhibitors for treating skin cancer
KR20210134690A (en) 2019-02-28 2021-11-10 리제너론 파아마슈티컬스, 인크. Administration of a PD-1 inhibitor to treat skin cancer
WO2020180727A1 (en) 2019-03-06 2020-09-10 Regeneron Pharmaceuticals, Inc. Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer
JP2022539830A (en) 2019-07-10 2022-09-13 ケモセントリックス，インコーポレイティド Indane as a PD-L1 inhibitor
GB201918692D0 (en) 2019-12-18 2020-01-29 Cambridge Entpr Ltd Treatment and prognosis of pancreatic cancer
TW202207940A (en) * 2020-04-14 2022-03-01 美商健生生物科技公司 Pharmaceutical composition for oral administration comprising aminopyrimidine derivative or pharmaceutically acceptable salt, hydrate, or solvate thereof
WO2021242728A1 (en) 2020-05-26 2021-12-02 Regeneron Pharmaceuticals, Inc. Methods of treating cervical cancer by administering the pd-1 inhibitor antibody cemiplimab
IL300328A (en) 2020-08-26 2023-04-01 Regeneron Pharma Methods of treating cancer by administering a pd-1 inhibitor
CN116194142A (en) 2020-09-03 2023-05-30 瑞泽恩制药公司 Methods of treating cancer pain by administering PD-1 inhibitors
AU2021362156A1 (en) * 2020-10-13 2023-06-15 Board Of Regents, The University Of Texas System Combinatorial immunotherapeutic methods and compositions for pancreatic ductal adenocarcinoma treatment
AU2022242000A1 (en) 2021-03-23 2023-09-14 Regeneron Pharmaceuticals, Inc. Methods of treating cancer in immunosuppressed or immunocompromised patients by administering a pd-1 inhibitor
IL310201A (en) 2021-07-19 2024-03-01 Regeneron Pharma Combination of checkpoint inhibitors and an oncolytic virus for treating cancer
WO2023079428A1 (en) 2021-11-03 2023-05-11 Pfizer Inc. Combination therapies using tlr7/8 agonist
WO2023159102A1 (en) 2022-02-17 2023-08-24 Regeneron Pharmaceuticals, Inc. Combinations of checkpoint inhibitors and oncolytic virus for treating cancer
WO2023230220A2 (en) * 2022-05-25 2023-11-30 Onconova Therapeutics, Inc. Methods and compositions for treating cancer

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11513382A (en) 1995-10-20 1999-11-16 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング 5-membered heterocyclic compounds, pharmaceuticals containing these compounds, their use and methods for their preparation
DE19539091A1 (en) 1995-10-20 1997-04-24 Thomae Gmbh Dr K New 5-membered heterocyclic compounds
US6756385B2 (en) 2000-07-31 2004-06-29 Pfizer Inc. Imidazole derivatives
GT200100147A (en) 2000-07-31 2002-06-25 IMIDAZOL DERIVATIVES
AU2001290258A1 (en) 2000-09-22 2002-04-02 Nihon Nohyaku Co. Ltd. N-(4-pyrazolyl)amide derivatives, chemicals for agricultural and horticultural use, and usage of the same
US20050256130A1 (en) 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
RU2342365C2 (en) 2003-05-01 2008-12-27 Бристол-Маерс Сквибб Компани Arylsubstituted pyrazolamides as kinases inhibitors
CA2609051A1 (en) 2005-05-19 2006-11-23 Cv Therapeutics, Inc. A1 adenosine receptor agonists
US7777035B2 (en) 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
NZ564258A (en) * 2005-06-22 2011-02-25 Chemocentryx Inc Azaindazole compounds and methods of use
FR2887450B1 (en) 2005-06-23 2007-08-24 Rhodia Chimie Sa CONCENTRATED INGREDIENT FOR THE TREATMENT AND / OR MODIFICATION OF SURFACES, AND ITS USE IN COSMETIC COMPOSITIONS
JPWO2007026834A1 (en) 2005-09-01 2009-03-12 クミアイ化学工業株式会社 Pyrazole derivatives and herbicides for agriculture and horticulture
WO2007044885A2 (en) 2005-10-11 2007-04-19 Chemocentryx, Inc. Piperidine derivatives and methods of use
US20090252779A1 (en) 2006-06-22 2009-10-08 Chemocentryx, Inc. Azaindazole compounds and methods of use
CA2675511A1 (en) 2006-10-10 2008-04-17 Amgen Inc. N-aryl pyrazole compounds for use against diabetes
US20100113776A1 (en) 2006-12-14 2010-05-06 Taisho Pharmaceutical Co.,Ltd. Pyrazole derivative
US7786157B2 (en) 2007-03-16 2010-08-31 Chemocentryx, Inc. OXO-imidazolidines as modulators of chemokine receptors
EP2155712B1 (en) 2007-05-22 2016-09-07 ChemoCentryx, Inc. 3-(imidazolyl)-pyrazolo[3,4-b]pyridines
AU2008266951B2 (en) 2007-06-18 2013-12-12 Merck Sharp & Dohme B.V. Antibodies to human programmed death receptor PD-1
SI3184527T1 (en) 2007-06-22 2020-03-31 Eli Lilly And Company 2,6-dioxo,-2,3-dihydro-1h-purine compounds useful for treating disorders related to the activity of the trpa1 channel
KR101571176B1 (en) 2007-11-13 2015-11-23 다이쇼 세이야꾸 가부시끼가이샤 Phenylpyrazole derivatives
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
CA2722811C (en) 2008-05-06 2016-07-05 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
WO2009140519A1 (en) 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
EP2323663B1 (en) * 2008-09-11 2015-02-25 ChemoCentryx, Inc. 4-amino-3-(imidazolyl)-pyrazolo[3,4-d]pyrimidines
DK2342226T3 (en) 2008-09-26 2016-09-26 Dana Farber Cancer Inst Inc HUMAN ANTI-PD-1, PD-L1 AND PD-L2 ANTIBODIES AND APPLICATIONS THEREOF
JP5844159B2 (en) 2009-02-09 2016-01-13 ユニヴェルシテ デクス−マルセイユＵｎｉｖｅｒｓｉｔｅ Ｄ’Ａｉｘ−Ｍａｒｓｅｉｌｌｅ PD-1 antibody and PD-L1 antibody and use thereof
GB0915892D0 (en) 2009-09-10 2009-10-14 Smithkline Beecham Corp Compounds
US8907053B2 (en) 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
EP2717895A1 (en) 2011-06-08 2014-04-16 Aurigene Discovery Technologies Limited Therapeutic compounds for immunomodulation
KR101981873B1 (en) 2011-11-28 2019-05-23 메르크 파텐트 게엠베하 Anti-pd-l1 antibodies and uses thereof
WO2013132317A1 (en) 2012-03-07 2013-09-12 Aurigene Discovery Technologies Limited Peptidomimetic compounds as immunomodulators
AU2013239366A1 (en) 2012-03-29 2014-10-16 Aurigene Discovery Technologies Limited Immunomodulating cyclic compounds from the BC loop of human PD1
CN104470949A (en) 2012-05-15 2015-03-25 百时美施贵宝公司 Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
EP2855528B1 (en) 2012-05-31 2019-06-19 Genentech, Inc. Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists
US9682143B2 (en) * 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
MX367436B (en) * 2012-08-27 2019-08-21 Chemocentryx Inc Antagonists of chemokine receptors.
CA2893597C (en) * 2012-12-07 2021-06-29 Chemocentryx, Inc. Diazole lactams
US9169248B2 (en) 2012-12-21 2015-10-27 Chemocentryx, Inc. Diazole amides
US9308236B2 (en) 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
MY183503A (en) * 2013-07-16 2021-02-23 Genentech Inc Method of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
ES2827679T3 (en) 2013-08-20 2021-05-24 Merck Sharp & Dohme Cancer treatment with a combination of a PD-1 antagonist and dinaciclib
AU2014315457B2 (en) 2013-09-04 2018-05-10 Bristol-Myers Squibb Company Compounds useful as immunomodulators
JP6474412B2 (en) 2013-09-06 2019-02-27 オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ Cyclic peptidomimetic compounds as immunomodulators
ES2788848T3 (en) 2013-09-06 2020-10-23 Aurigene Discovery Tech Ltd 1,2,4-Oxadiazole derivatives as immunomodulators
SG11201601679TA (en) 2013-09-06 2016-04-28 Aurigene Discovery Tech Ltd 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
WO2015036927A1 (en) 2013-09-10 2015-03-19 Aurigene Discovery Technologies Limited Immunomodulating peptidomimetic derivatives
WO2015044900A1 (en) 2013-09-27 2015-04-02 Aurigene Discovery Technologies Limited Therapeutic immunomodulating compounds
TWI680138B (en) 2014-01-23 2019-12-21 美商再生元醫藥公司 Human antibodies to pd-l1
US9850225B2 (en) 2014-04-14 2017-12-26 Bristol-Myers Squibb Company Compounds useful as immunomodulators
CN107074945B (en) * 2014-05-27 2021-08-24 中央研究院 Compositions and methods for enhancing the efficacy of antibodies
CN106573060A (en) * 2014-07-15 2017-04-19 豪夫迈·罗氏有限公司 Compositions for treating cancer using PD-1 axis binding antagonists and MEK inhibitors
TN2017000084A1 (en) 2014-09-11 2018-07-04 Bristol Myers Squibb Co Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-li protein/protein interactions
US9732119B2 (en) 2014-10-10 2017-08-15 Bristol-Myers Squibb Company Immunomodulators
US9856292B2 (en) 2014-11-14 2018-01-02 Bristol-Myers Squibb Company Immunomodulators
US9861680B2 (en) 2014-12-18 2018-01-09 Bristol-Myers Squibb Company Immunomodulators
US9944678B2 (en) 2014-12-19 2018-04-17 Bristol-Myers Squibb Company Immunomodulators
US20160222060A1 (en) 2015-02-04 2016-08-04 Bristol-Myers Squibb Company Immunomodulators
WO2016142852A1 (en) 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 1,3,4-oxadiazole and thiadiazole compounds as immunomodulators
CA2979161A1 (en) 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
AU2016230795A1 (en) 2015-03-10 2017-09-07 Aurigene Discovery Technologies Limited Therapeutic cyclic compounds as immunomodulators
BR112017019307A2 (en) 2015-03-10 2018-05-02 Aurigene Discovery Technologies Limited 3-substituted 1,3,4-oxadiazole compounds and thiadiazole as immunomodulators
EA034708B1 (en) 2015-03-10 2020-03-10 Ауриджен Дискавери Текнолоджис Лимитед 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
US9809625B2 (en) 2015-03-18 2017-11-07 Bristol-Myers Squibb Company Immunomodulators
PT3439653T (en) 2016-04-07 2021-03-25 Chemocentryx Inc Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors

Also Published As

Publication number Publication date
US20170290808A1 (en) 2017-10-12
KR20190020291A (en) 2019-02-28
WO2017176965A1 (en) 2017-10-12
BR112018070361A2 (en) 2019-01-29
DK3439653T3 (en) 2021-03-29
IL261998A (en) 2018-10-31
US10568870B2 (en) 2020-02-25
IL261998B (en) 2022-11-01
KR102370704B1 (en) 2022-03-03
PT3439653T (en) 2021-03-25
IL261998B2 (en) 2023-03-01
MX2018012132A (en) 2019-03-28
ES2864148T3 (en) 2021-10-13
TWI808938B (en) 2023-07-21
RU2745195C2 (en) 2021-03-22
AU2017246460B2 (en) 2021-04-22
CA3019391A1 (en) 2017-10-12
US11744822B2 (en) 2023-09-05
EP3439653A1 (en) 2019-02-13
EP3439653A4 (en) 2019-12-04
RU2018138828A (en) 2020-05-15
US20200289472A1 (en) 2020-09-17
ZA201806633B (en) 2021-04-28
RU2018138828A3 (en) 2020-08-12
PL3439653T3 (en) 2021-07-05
JP2022130424A (en) 2022-09-06
AU2017246460A1 (en) 2018-10-25
JP2019510832A (en) 2019-04-18
TW201801724A (en) 2018-01-16
CN109310677A (en) 2019-02-05
EP3439653B1 (en) 2021-01-20
AR108202A1 (en) 2018-07-25

Similar Documents

Publication Publication Date Title
ZA201806633B (en) Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors
HK1249524A1 (en) Immune-checkpoint inhibitors for use in the treatment of blood-borne cancers
IL276314A (en) Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors
IL252251A0 (en) Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
IL249133B (en) Methods of cancer treatment with antagonists against pd-1 and pd-l1 in combination with radiation therapy
IL256085B (en) A substituted derivative of cholanoic acid, a pharmaceutical composition comprising it and the substituted derivative for use in treatment
IL256166B (en) Compounds for use in treating neuromuscular disorders
ZA201608077B (en) Combination, composition, and method of administering the combination or composition to animals
IL258246B (en) Isolidine compound, pharmaceutical compositions comprising same, their combinations with therapeutic agents for use in the treatment of cancer
MX2015011899A (en) Methods of treating cancer and preventing cancer drug resistance.
IL263110A (en) Combination therapy with notch and pd-1 or pd-l1 inhibitors
IL247589A0 (en) Dihydropyridinone mgat2 inhibitors for use in the treatment of metabolic disorders
IL246855A0 (en) Agents for use in the treatment of retinal inflammation
EP3223793A4 (en) Compositions and methods for delivering a bio-active agent or bio-active agents
HK1232128A1 (en) Pharmaceutical composition for preventing or treating skin rash
MX2015013755A (en) Pharmaceutical formulation for use in the treatment and/or prevention of restenosis.
IL247684A0 (en) Cannula for use in intraosseous injections
EP3291818A4 (en) Compositions and methods for delivering therapeutic agents into the colon
IL280389A (en) A substituted derivative of cholanoic acid, a pharmaceutical composition comprising it and the substituted derivative for use in treatment
IL253933A0 (en) Pyrimidine derivatives for use in the treatment of cancer
EP3194030A4 (en) Substituted phenylpyrrolecarboxamides with therapeutic activity in hiv