CN105980580B - 用于探测、检测和分析分子的光学系统和测定芯片 - Google Patents
用于探测、检测和分析分子的光学系统和测定芯片 Download PDFInfo
- Publication number
- CN105980580B CN105980580B CN201480073505.9A CN201480073505A CN105980580B CN 105980580 B CN105980580 B CN 105980580B CN 201480073505 A CN201480073505 A CN 201480073505A CN 105980580 B CN105980580 B CN 105980580B
- Authority
- CN
- China
- Prior art keywords
- sample
- excitation
- energy
- sensor
- sample well
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
- G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N21/7746—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the waveguide coupled to a cavity resonator
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/168—Specific optical properties, e.g. reflective coatings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/101—DNA polymerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/101—Modifications characterised by incorporating non-naturally occurring nucleotides, e.g. inosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/157—A reaction step characterised by the number of molecules incorporated or released
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/103—Nucleic acid detection characterized by the use of physical, structural and functional properties luminescence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/607—Detection means characterised by use of a special device being a sensor, e.g. electrode
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6478—Special lenses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
- G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
- G01N2201/0612—Laser diodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/062—LED's
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/068—Optics, miscellaneous
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/125—Digital circuitry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
- Y10T29/49016—Antenna or wave energy "plumbing" making
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Plasma & Fusion (AREA)
- Biomedical Technology (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Optical Measuring Cells (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910752352.5A CN110452809B (zh) | 2013-11-17 | 2014-11-17 | 与测定芯片通过接口连接的仪器 |
| CN202010074109.5A CN111235246B (zh) | 2013-11-17 | 2014-11-17 | 用于探测、检测和分析分子的光学系统和测定芯片 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361905282P | 2013-11-17 | 2013-11-17 | |
| US61/905,282 | 2013-11-17 | ||
| US201361917926P | 2013-12-18 | 2013-12-18 | |
| US61/917,926 | 2013-12-18 | ||
| US201461941916P | 2014-02-19 | 2014-02-19 | |
| US61/941,916 | 2014-02-19 | ||
| PCT/US2014/066010 WO2015074001A1 (en) | 2013-11-17 | 2014-11-17 | Optical system and assay chip for probing, detecting and analyzing molecules |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910752352.5A Division CN110452809B (zh) | 2013-11-17 | 2014-11-17 | 与测定芯片通过接口连接的仪器 |
| CN202010074109.5A Division CN111235246B (zh) | 2013-11-17 | 2014-11-17 | 用于探测、检测和分析分子的光学系统和测定芯片 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105980580A CN105980580A (zh) | 2016-09-28 |
| CN105980580B true CN105980580B (zh) | 2020-03-03 |
Family
ID=52014380
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910752352.5A Active CN110452809B (zh) | 2013-11-17 | 2014-11-17 | 与测定芯片通过接口连接的仪器 |
| CN201480073505.9A Active CN105980580B (zh) | 2013-11-17 | 2014-11-17 | 用于探测、检测和分析分子的光学系统和测定芯片 |
| CN201480073365.5A Pending CN106029904A (zh) | 2013-11-17 | 2014-11-17 | 用于探测、检测和分析分子的具有外部光源的集成装置 |
| CN201480073394.1A Pending CN105917003A (zh) | 2013-11-17 | 2014-11-17 | 用于生物和化学试样的快速分析的有源像素集成装置 |
| CN202010074109.5A Active CN111235246B (zh) | 2013-11-17 | 2014-11-17 | 用于探测、检测和分析分子的光学系统和测定芯片 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910752352.5A Active CN110452809B (zh) | 2013-11-17 | 2014-11-17 | 与测定芯片通过接口连接的仪器 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480073365.5A Pending CN106029904A (zh) | 2013-11-17 | 2014-11-17 | 用于探测、检测和分析分子的具有外部光源的集成装置 |
| CN201480073394.1A Pending CN105917003A (zh) | 2013-11-17 | 2014-11-17 | 用于生物和化学试样的快速分析的有源像素集成装置 |
| CN202010074109.5A Active CN111235246B (zh) | 2013-11-17 | 2014-11-17 | 用于探测、检测和分析分子的光学系统和测定芯片 |
Country Status (10)
| Country | Link |
|---|---|
| US (12) | US10048208B2 (enExample) |
| EP (6) | EP3709003A1 (enExample) |
| JP (5) | JP6673843B2 (enExample) |
| KR (4) | KR102221637B1 (enExample) |
| CN (5) | CN110452809B (enExample) |
| AU (4) | AU2014348306B2 (enExample) |
| BR (3) | BR112016011084B8 (enExample) |
| CA (3) | CA2930836A1 (enExample) |
| MX (4) | MX381541B (enExample) |
| WO (3) | WO2015074004A1 (enExample) |
Families Citing this family (198)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9593371B2 (en) | 2013-12-27 | 2017-03-14 | Intel Corporation | Integrated photonic electronic sensor arrays for nucleic acid sequencing |
| CN110452809B (zh) | 2013-11-17 | 2022-07-01 | 宽腾矽公司 | 与测定芯片通过接口连接的仪器 |
| WO2015117157A1 (en) * | 2014-02-03 | 2015-08-06 | Electromagnetic Landmarks Inc. | Magnetic sensor array and system |
| US11287484B2 (en) | 2014-02-03 | 2022-03-29 | Innovaura Corporation | Method and apparatus for triage of electronic items using magnetic field detection |
| US11747407B2 (en) | 2014-02-03 | 2023-09-05 | Innovaura Corporation | System and method for characterizing defects in electronic items using magnetic field detection |
| CN112903639B (zh) | 2014-08-08 | 2022-09-13 | 宽腾矽公司 | 用于对分子进行探测、检测和分析的带外部光源的集成装置 |
| BR112017002489B1 (pt) | 2014-08-08 | 2023-02-14 | Quantum-Si Incorporated | Instrumento configurado para fazer interface com um chip de teste, aparelho, método de análise de um espécime, método para sequenciar uma molécula-alvo de ácido nucleico e método para sequenciamento de ácido nucleico |
| AU2015300766B2 (en) | 2014-08-08 | 2021-02-04 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
| US10174363B2 (en) | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
| US9721751B2 (en) * | 2014-08-22 | 2017-08-01 | The Board Of Trustees Of The Leland Stanford Junior University | Electron microscopy specimen and method of fabrication |
| US9506908B2 (en) | 2014-10-06 | 2016-11-29 | Alveo Technologies, Inc. | System for detection of analytes |
| US10627358B2 (en) | 2014-10-06 | 2020-04-21 | Alveo Technologies, Inc. | Method for detection of analytes |
| US9921182B2 (en) | 2014-10-06 | 2018-03-20 | ALVEO Technologies Inc. | System and method for detection of mercury |
| US10196678B2 (en) | 2014-10-06 | 2019-02-05 | ALVEO Technologies Inc. | System and method for detection of nucleic acids |
| US10352899B2 (en) | 2014-10-06 | 2019-07-16 | ALVEO Technologies Inc. | System and method for detection of silver |
| US10184892B2 (en) * | 2014-10-29 | 2019-01-22 | Horiba Instruments Incorporated | Determination of water treatment parameters based on absorbance and fluorescence |
| EP3247993B1 (en) | 2015-01-20 | 2019-05-08 | Hyris Limited | Detector for measuring fluorescence in a liquid sample |
| US10018608B2 (en) * | 2015-02-27 | 2018-07-10 | Vitaly Talyansky | System to authenticate and identify items |
| CN113064236B (zh) | 2015-03-16 | 2022-11-01 | 加利福尼亚太平洋生物科学股份有限公司 | 用于自由空间光耦合的集成装置及系统 |
| US11466316B2 (en) | 2015-05-20 | 2022-10-11 | Quantum-Si Incorporated | Pulsed laser and bioanalytic system |
| US10605730B2 (en) | 2015-05-20 | 2020-03-31 | Quantum-Si Incorporated | Optical sources for fluorescent lifetime analysis |
| US9874693B2 (en) | 2015-06-10 | 2018-01-23 | The Research Foundation For The State University Of New York | Method and structure for integrating photonics with CMOs |
| WO2016201387A1 (en) | 2015-06-12 | 2016-12-15 | Pacific Biosciences Of California, Inc. | Integrated target waveguide devices and systems for optical coupling |
| US9891171B2 (en) * | 2015-07-27 | 2018-02-13 | Personal Genomics, Inc. | Sensing module and sensing method |
| WO2017019768A1 (en) | 2015-07-30 | 2017-02-02 | The Regents Of The University Of California | Optical cavity pcr |
| US20180252646A1 (en) * | 2015-08-18 | 2018-09-06 | Agency For Scien, Technology And Research | Optical structure and optical light detection system |
| US9733188B2 (en) * | 2015-09-21 | 2017-08-15 | International Business Machines Corporation | Enhancing on-chip fluorescence detection |
| EP3374758B1 (en) * | 2015-10-22 | 2025-03-05 | Jacob Schneiderman | Systems and methods for identifying biological materials |
| KR101720434B1 (ko) * | 2015-11-10 | 2017-03-28 | 한국과학기술원 | 광 위상배열 안테나 |
| US10248838B2 (en) * | 2015-12-04 | 2019-04-02 | The Regents Of The University Of California | Method and device for single molecule imaging |
| US10352856B2 (en) * | 2015-12-14 | 2019-07-16 | Massachusetts Institute Of Technology | Apparatus and methods for spectroscopy and broadband light emission using two-dimensional plasmon fields |
| WO2017123658A1 (en) | 2016-01-12 | 2017-07-20 | Sxaymiq Technologies Llc | Light emitting diode display |
| JP7280590B2 (ja) * | 2016-01-28 | 2023-05-24 | ロズウェル バイオテクノロジーズ,インコーポレイテッド | 大スケールの分子電子工学センサアレイを使用する被分析物を測定するための方法および装置 |
| EP4137808A1 (en) | 2016-01-28 | 2023-02-22 | Roswell Biotechnologies, Inc. | Method of making a sequencing device |
| KR102734671B1 (ko) | 2016-02-09 | 2024-11-25 | 로스웰 엠이 아이엔씨. | 전자 비표지 dna 및 게놈 시퀀싱 |
| TWI734748B (zh) | 2016-02-17 | 2021-08-01 | 美商太斯萊特健康股份有限公司 | 用於生命期成像及偵測應用之感測器及裝置 |
| US10597767B2 (en) | 2016-02-22 | 2020-03-24 | Roswell Biotechnologies, Inc. | Nanoparticle fabrication |
| WO2017165817A1 (en) * | 2016-03-25 | 2017-09-28 | Bioceryx Inc. | Apparatuses and methods for assessing target sequence numbers |
| US11579336B2 (en) * | 2016-04-22 | 2023-02-14 | Illumina, Inc. | Photonic structure-based devices and compositions for use in luminescent imaging of multiple sites within a pixel, and methods of using the same |
| US10451518B2 (en) * | 2016-05-10 | 2019-10-22 | Rd2, Llc | All fiber temperature and air density sensor |
| WO2017205868A1 (en) * | 2016-05-27 | 2017-11-30 | Singulex, Inc. | Camera-based single molecule reader |
| US11389277B2 (en) | 2016-07-18 | 2022-07-19 | David Akselrod | Material property monitoring using backscatter devices |
| US11529213B2 (en) | 2016-05-30 | 2022-12-20 | David Akselrod | Backscatter device-based dental imaging apparatus |
| KR102627237B1 (ko) * | 2016-06-01 | 2024-01-23 | 퀀텀-에스아이 인코포레이티드 | 분자들을 검출 및 분석하기 위한 통합 디바이스 |
| US10711299B2 (en) | 2016-06-01 | 2020-07-14 | Quantum-Si Incorporated | Pulse caller and base caller |
| US10758153B2 (en) * | 2016-07-18 | 2020-09-01 | David Akselrod | Material property monitoring and detection using wireless devices |
| US9829456B1 (en) | 2016-07-26 | 2017-11-28 | Roswell Biotechnologies, Inc. | Method of making a multi-electrode structure usable in molecular sensing devices |
| WO2018026725A1 (en) * | 2016-08-01 | 2018-02-08 | Genprime, Inc. | System and method to interpret tests that change color to indicate the presence or non-presence of a compound |
| US10656088B2 (en) * | 2016-08-12 | 2020-05-19 | Silanna UV Technologies Pte Ltd | Ultraviolet biosensor |
| EP3285052A1 (en) | 2016-08-19 | 2018-02-21 | IMEC vzw | Photonic circuit with integrated light coupler |
| US11465141B2 (en) | 2016-09-23 | 2022-10-11 | Alveo Technologies, Inc. | Methods and compositions for detecting analytes |
| TWI826089B (zh) * | 2016-11-03 | 2023-12-11 | 大陸商深圳華大智造科技有限公司 | 用於生物或化學分析的生物感測器以及製造其的方法 |
| FR3058521B1 (fr) * | 2016-11-08 | 2021-01-08 | Univ Montpellier | Dispositif et procede de detection de presence de molecules determinees, biocapteur |
| WO2018109102A1 (en) * | 2016-12-15 | 2018-06-21 | F. Hoffmann-La Roche Ag | Adaptive nanopore signal compression |
| JP7050068B2 (ja) | 2016-12-16 | 2022-04-07 | クアンタム-エスアイ インコーポレイテッド | コンパクトなビーム成形およびステアリングアセンブリ |
| CN110088993B (zh) | 2016-12-16 | 2022-02-08 | 宽腾矽公司 | 紧密的锁模雷射模块 |
| JP2018100959A (ja) * | 2016-12-16 | 2018-06-28 | シャープ株式会社 | 検出器、ならびに、検出器の校正方法、補正方法、検出装置 |
| EP3555314B1 (en) | 2016-12-19 | 2023-08-16 | Quantum-Si Incorporated | Loading molecules into sample wells for analysis |
| CA3047826A1 (en) | 2016-12-22 | 2018-06-28 | Quantum-Si Incorporated | Integrated photodetector with direct binning pixel |
| CA3052062A1 (en) | 2017-01-10 | 2018-07-19 | Roswell Biotechnologies, Inc. | Methods and systems for dna data storage |
| WO2018136148A1 (en) | 2017-01-19 | 2018-07-26 | Roswell Biotechnologies, Inc. | Solid state sequencing devices comprising two dimensional layer materials |
| US11419703B2 (en) | 2017-01-27 | 2022-08-23 | David Akselrod | Orthodontic braces and feet orthotics with backscatter based sensors |
| KR101847334B1 (ko) * | 2017-02-02 | 2018-04-10 | 한국기초과학지원연구원 | 형광 이미지 획득 장치 및 방법 |
| GB201701829D0 (en) * | 2017-02-03 | 2017-03-22 | Norwegian Univ Of Science And Tech (Ntnu) | Device |
| CN111936837B (zh) * | 2017-02-08 | 2024-06-07 | 上海宜晟生物科技有限公司 | Qmax测定及应用 |
| WO2018170518A1 (en) * | 2017-03-17 | 2018-09-20 | Apton Biosystems, Inc. | Sequencing and high resolution imaging |
| EP3602629B1 (en) | 2017-03-20 | 2024-07-03 | MGI Tech Co., Ltd. | Biosensors for biological or chemical analysis and methods of manufacturing the same |
| US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
| EP3615685B1 (en) | 2017-04-25 | 2025-02-19 | Roswell Biotechnologies, Inc | Enzymatic circuits for molecular sensors |
| US11224878B2 (en) | 2017-05-05 | 2022-01-18 | Quantum-Si Incorporated | Substrates having modified surface reactivity and antifouling properties in biological reactions |
| CA3057155A1 (en) | 2017-05-09 | 2018-11-15 | Roswell Biotechnologies, Inc. | Binding probe circuits for molecular sensors |
| EP4191236A1 (en) * | 2017-05-23 | 2023-06-07 | Hamamatsu Photonics K.K. | Orientation characteristic measurement method, orientation characteristic measurement program, and orientation characteristic measurement device |
| EP3639013A4 (en) * | 2017-06-16 | 2021-06-30 | Duke University | Resonator networks for improved label detection, computation, analyte sensing, and tunable random number generation |
| CN109103090B (zh) * | 2017-06-21 | 2020-12-04 | 清华大学 | 纳米带的制备方法 |
| KR102083396B1 (ko) * | 2017-06-28 | 2020-03-02 | 주식회사 파나진 | 양자점을 분산광원으로 하는 표적 핵산 검출 방법 |
| CN107390172B (zh) * | 2017-07-17 | 2020-04-28 | 北京大学 | 一种无接触感知定位方法 |
| WO2019023174A1 (en) | 2017-07-24 | 2019-01-31 | Quantum-Si Incorporated | MASSIVELY PARALLEL BIO-OPTOELECTRONIC INSTRUMENT HAND-HELD |
| JP7212030B2 (ja) * | 2017-07-24 | 2023-01-24 | クアンタム-エスアイ インコーポレイテッド | 光拒絶フォトニック構造 |
| CN107402199B (zh) * | 2017-07-31 | 2019-09-10 | 京东方科技集团股份有限公司 | 基因测序芯片及其测序方法以及基因测序装置 |
| CN111566261B (zh) | 2017-08-18 | 2025-03-25 | 诺迪勒思附属公司 | 选择结合试剂的方法 |
| US11371955B2 (en) | 2017-08-30 | 2022-06-28 | Roswell Biotechnologies, Inc. | Processive enzyme molecular electronic sensors for DNA data storage |
| CN118045644A (zh) | 2017-09-19 | 2024-05-17 | 深圳华大智造科技股份有限公司 | 晶片级测序流通池制造 |
| CN111373051A (zh) | 2017-10-10 | 2020-07-03 | 罗斯威尔生命技术公司 | 用于无扩增dna数据存储的方法、装置和系统 |
| EP3501651B1 (en) * | 2017-12-22 | 2024-03-06 | IMEC vzw | Microfluidic routing |
| KR102239487B1 (ko) | 2018-01-08 | 2021-04-14 | 일루미나, 인코포레이티드 | 반도체-기반 검출을 사용한 고-처리율 서열분석 |
| CN111867729B (zh) | 2018-01-08 | 2022-06-10 | 宽腾矽公司 | 用于亚微米级反应室的电气动力装载的系统及方法 |
| CN108197052B (zh) * | 2018-01-17 | 2021-02-26 | 上海聚星仪器有限公司 | 一种新型测试测量仪器 |
| JP2021511829A (ja) | 2018-01-26 | 2021-05-13 | クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated | シークエンシングデバイスに関する機械学習可能なパルス決定および塩基決定 |
| IT201800004146A1 (it) * | 2018-03-30 | 2019-09-30 | St Microelectronics Srl | Apparecchio di analisi di molecole tramite rilevamento di segnali fluorescenti e relativo metodo |
| US10965102B2 (en) * | 2018-04-12 | 2021-03-30 | Samsung Electronics Co., Ltd. | Structured light projector and electronic apparatus including the same |
| CN112424587A (zh) | 2018-06-15 | 2021-02-26 | 宽腾矽公司 | 用于具有脉冲光源的先进分析仪器的数据采集控制 |
| EP3581919B1 (en) * | 2018-06-15 | 2022-03-23 | IMEC vzw | An imaging apparatus and a method for imaging an object |
| KR102546320B1 (ko) * | 2018-06-18 | 2023-06-22 | 삼성전자주식회사 | 구조광 프로젝터 및 이를 포함하는 전자 장치 |
| CA3108295A1 (en) | 2018-06-22 | 2019-12-26 | Quantum-Si Incorporated | Integrated photodetector with charge storage bin of varied detection time |
| US11619580B2 (en) | 2018-07-23 | 2023-04-04 | The University Of Chicago | Resonator-based ion-selective sensor |
| US20200072752A1 (en) * | 2018-08-29 | 2020-03-05 | Quantum-Si Incorporated | System and methods for detecting lifetime using photon counting photodetectors |
| KR20210049145A (ko) * | 2018-08-29 | 2021-05-04 | 퀀텀-에스아이 인코포레이티드 | 통합 센서 디바이스들을 위한 샘플 웰 제작 기술들 및 구조물들 |
| JP6906489B2 (ja) | 2018-09-14 | 2021-07-21 | 株式会社東芝 | ケミカルセンサキット及び分析方法 |
| US11509116B2 (en) * | 2018-10-23 | 2022-11-22 | Analog Photonics LLC | Athermal angular output by combining a laser with a grating based antenna |
| CN111135878B (zh) * | 2018-11-06 | 2021-10-15 | 京东方科技集团股份有限公司 | 微流体通道结构及制作方法、微流体检测装置及使用方法 |
| WO2020094233A1 (de) * | 2018-11-08 | 2020-05-14 | Diamontech Ag | Vorrichtung und verfahren zum analysieren eines stoffs |
| JP2022507516A (ja) | 2018-11-15 | 2022-01-18 | クアンタム-エスアイ インコーポレイテッド | タンパク質シーケンシングのための方法及び組成物 |
| US11993865B2 (en) | 2018-11-20 | 2024-05-28 | Nautilus Subsidiary, Inc. | Selection of affinity reagents |
| JP2020085666A (ja) * | 2018-11-26 | 2020-06-04 | ソニーセミコンダクタソリューションズ株式会社 | 生体由来物質検出用チップ、生体由来物質検出装置及び生体由来物質検出システム |
| US12179204B2 (en) | 2018-12-03 | 2024-12-31 | Quantum-Si Incorporated | Sample well fabrication techniques and structures for integrated sensor |
| EP3899022A4 (en) | 2018-12-20 | 2023-03-01 | Alveo Technologies Inc. | PORTABLE IMPEDANCE-BASED DIAGNOSTIC TEST SYSTEM FOR DETECTING ANALYTES |
| MX2021008133A (es) * | 2019-01-03 | 2021-08-11 | Quantum Si Inc | Guias de ondas opticas y acopladores para suministrar luz a un conjunto de elementos fotonicos. |
| TWI687687B (zh) * | 2019-01-11 | 2020-03-11 | 國立中正大學 | 雙光柵感測器、檢測方法及其製備方法 |
| CN113767160B (zh) * | 2019-03-04 | 2025-02-28 | 免疫之光有限责任公司 | 用于能量发射体和收集体的能量增强结构 |
| MX2021010690A (es) * | 2019-03-05 | 2021-10-01 | Quantum Si Inc | Filtro de absorcion optica para un dispositivo integrado. |
| EP4648576A2 (en) | 2019-03-08 | 2025-11-12 | Infinite Potential Laboratories LP | Quantum control devices and methods |
| WO2020190063A1 (ko) * | 2019-03-20 | 2020-09-24 | (주)바이오스퀘어 | 바이오 분석기기 검증용 표준물질 조성물 및 이를 이용한 표준 스트립 |
| US11534755B2 (en) | 2019-04-16 | 2022-12-27 | Boe Technology Group Co., Ltd. | Micro-channel device and manufacturing method thereof and micro-fluidic system |
| WO2020223368A1 (en) | 2019-04-29 | 2020-11-05 | Nautilus Biotechnology, Inc. | Methods and systems for integrated on-chip single-molecule detection |
| CN110066723A (zh) * | 2019-05-05 | 2019-07-30 | 京东方科技集团股份有限公司 | 基因测序芯片、设备、制造方法 |
| US11747561B2 (en) | 2019-06-14 | 2023-09-05 | Quantum-Si Incorporated | Sliced grating coupler with increased beam alignment sensitivity |
| US11009611B2 (en) | 2019-06-18 | 2021-05-18 | Eagle Technology, Llc | Radiation detection system with surface plasmon resonance detection and related methods |
| CN110229747A (zh) * | 2019-06-18 | 2019-09-13 | 京东方科技集团股份有限公司 | 基因测序芯片、设备及制备方法 |
| US11085878B2 (en) | 2019-06-18 | 2021-08-10 | Eagle Technology, Llc | Radiation detection system with surface plasmon resonance detection and related methods |
| CA3144003A1 (en) | 2019-06-19 | 2020-12-24 | Quantum-Si Incorporated | Optical nanostructure rejecter for an integrated device and related methods |
| US11280737B2 (en) * | 2019-06-20 | 2022-03-22 | Cilag Gmbh International | Super resolution and color motion artifact correction in a pulsed fluorescence imaging system |
| US11793399B2 (en) | 2019-06-20 | 2023-10-24 | Cilag Gmbh International | Super resolution and color motion artifact correction in a pulsed hyperspectral imaging system |
| WO2020262092A1 (ja) * | 2019-06-26 | 2020-12-30 | ソニー株式会社 | 光学測定装置及び光学測定システム |
| WO2021007039A1 (en) * | 2019-07-08 | 2021-01-14 | Illumina, Inc. | Waveguide integration with optical coupling structures on light detection device |
| AU2020326781A1 (en) | 2019-08-08 | 2022-03-17 | Quantum-Si Incorporated | Increased emission collection efficiency in integrated optical devices |
| EP4021909A4 (en) | 2019-08-29 | 2023-08-30 | David C. Martin | Biofunctional thiophene monomers |
| US12146852B2 (en) | 2019-09-06 | 2024-11-19 | Roswell Biotechnologies, Inc. | Methods of fabricating nanoscale structures usable in molecular sensors and other devices |
| US10957731B1 (en) | 2019-10-04 | 2021-03-23 | Visera Technologies Company Limited | Sensor device and method for manufacturing the same |
| US11105745B2 (en) | 2019-10-10 | 2021-08-31 | Visera Technologies Company Limited | Biosensor |
| US11705472B2 (en) * | 2019-10-10 | 2023-07-18 | Visera Technologies Company Limited | Biosensor and method of distinguishing a light |
| US11630062B2 (en) * | 2019-10-10 | 2023-04-18 | Visera Technologies Company Limited | Biosensor and method of forming the same |
| JP2022551523A (ja) | 2019-10-11 | 2022-12-09 | クアンタム-エスアイ インコーポレイテッド | 気相における表面修飾 |
| AU2020372908A1 (en) | 2019-10-29 | 2022-06-02 | Quantum-Si Incorporated | Peristaltic pumping of fluids and associated methods, systems, and devices |
| TWI704342B (zh) * | 2019-11-28 | 2020-09-11 | 雷科股份有限公司 | Aoi(自動光學檢測)應用在雷射蝕薄銅線圈的方法及其設備 |
| US11703454B2 (en) | 2020-01-03 | 2023-07-18 | Korea Advanced Institute Of Science And Technology | Method and apparatus for multiplexed imaging of spectrally-similar fluorophores |
| KR102351249B1 (ko) * | 2020-01-03 | 2022-01-14 | 한국과학기술원 | 분자 다중 이미징 방법 및 장치 |
| US11784416B2 (en) * | 2020-01-06 | 2023-10-10 | Raytheon Company | Tunable radio frequency (RF) absorber and thermal heat spreader |
| IL294731A (en) | 2020-01-14 | 2022-09-01 | Quantum Si Inc | Integrated sensor for life time characterization |
| JP2023510578A (ja) | 2020-01-14 | 2023-03-14 | クアンタム-エスアイ インコーポレイテッド | 寿命およびスペクトル特性評価用センサ |
| US12170433B2 (en) | 2020-01-14 | 2024-12-17 | Quantum-Si Incorporated | Amplitude-modulated laser |
| US20230114049A1 (en) * | 2020-01-24 | 2023-04-13 | Deepdivebio, Inc. | Optical array qpcr |
| CN111308530B (zh) * | 2020-02-17 | 2021-12-03 | 中国人民解放军战略支援部队信息工程大学 | 一种基于二维波达方向的短波多站和单星协同直接定位方法 |
| EP4111178A1 (en) | 2020-03-02 | 2023-01-04 | Quantum-si Incorporated | Integrated sensor for multi-dimensional signal analysis |
| EP4133524A2 (en) | 2020-04-08 | 2023-02-15 | Quantum-si Incorporated | Integrated sensor with reduced skew |
| CN111533083B (zh) * | 2020-05-08 | 2023-09-05 | 中北大学 | 一种基于石墨烯的微型分子光镊 |
| CA3177375A1 (en) | 2020-05-20 | 2021-11-25 | Quantum-Si Incorporated | Methods and compositions for protein sequencing |
| CA3182266A1 (en) | 2020-06-11 | 2021-12-16 | Vadim Lobanov | Methods and systems for computational decoding of biological, chemical, and physical entities |
| CN116472302A (zh) * | 2020-07-07 | 2023-07-21 | 特韦斯特生物科学公司 | 用于光引导聚合物合成的装置和方法 |
| KR20230056685A (ko) * | 2020-07-23 | 2023-04-27 | 라이프 테크놀로지스 코포레이션 | 염료를 사용한 생물학적 분석을 위한 조성물, 시스템 및 방법 |
| US12472492B2 (en) | 2020-08-14 | 2025-11-18 | Alveo Technologies, Inc. | Systems and methods of sample depositing and testing |
| KR102628182B1 (ko) * | 2020-08-28 | 2024-01-24 | 한국과학기술원 | 상호정보량 최소화를 통한 다색 분리 방법 및 장치 |
| EP3961194B1 (en) | 2020-08-25 | 2023-11-08 | Korea Advanced Institute of Science and Technology | Method and apparatus for multiplexed imaging of biomolecules through iterative unmixing of fluorophore signals |
| KR102423723B1 (ko) * | 2020-08-27 | 2022-07-21 | 성균관대학교산학협력단 | 플라즈모닉 우물 기반 핵산 검출장치 및 롤투롤 공정을 이용한 이의 제조방법 |
| GB2599729A (en) * | 2020-10-12 | 2022-04-13 | Sumitomo Chemical Co | Method comprising light emitting marker |
| US20220128469A1 (en) * | 2020-10-27 | 2022-04-28 | Quantum-Si Incorporated | Single molecule detection system using photobleaching information |
| TWI824273B (zh) * | 2020-12-03 | 2023-12-01 | 仁寶電腦工業股份有限公司 | 天線裝置和配置該天線裝置的方法 |
| EP4251975A4 (en) | 2020-12-15 | 2024-09-18 | Quantum-si Incorporated | MOLECULAR BARCODE ANALYSIS BY SINGLE MOLECULE KINETICS |
| AU2022209365A1 (en) | 2021-01-21 | 2023-07-20 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule preparation |
| CN112837620B (zh) * | 2021-01-22 | 2023-07-04 | 武汉京东方光电科技有限公司 | 柔性显示屏及电子设备 |
| CN112864258B (zh) * | 2021-03-05 | 2025-01-10 | 南京扬字源科技有限公司 | 像素结构、红外图像传感器和电子设备 |
| IL305336B2 (en) | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| CA3219059A1 (en) * | 2021-05-04 | 2022-11-10 | Pacific Biosciences Of California, Inc. | Arrays of integrated analytical devices with reduced-scale unit cell |
| DE102021111787A1 (de) * | 2021-05-06 | 2022-11-10 | Gesellschaft für angewandte Mikro- und Optoelektronik mit beschränkter Haftung - AMO GmbH | Verfahren zur Herstellung einer Lochblende, Lochblende sowie Verwendung einer Lochblende in einem optischen Aufbau |
| CN112986206B (zh) * | 2021-05-20 | 2021-07-30 | 北京百奥纳芯生物科技有限公司 | 一种检测基因芯片杂交结果的方法 |
| US11703445B2 (en) * | 2021-05-28 | 2023-07-18 | Visera Technologies Company Limited | Biosensor with grating array |
| US20230070896A1 (en) | 2021-09-09 | 2023-03-09 | Nautilus Biotechnology, Inc. | Characterization and localization of protein modifications |
| JP2024537689A (ja) | 2021-09-22 | 2024-10-16 | ノーティラス・サブシディアリー・インコーポレイテッド | ポリペプチド相互作用を決定するための方法及びシステム |
| US20230114694A1 (en) * | 2021-10-11 | 2023-04-13 | Quantum-Si Incorporated | Light coupling device |
| US20230149883A1 (en) | 2021-11-03 | 2023-05-18 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| US20230152211A1 (en) * | 2021-11-11 | 2023-05-18 | California Institute Of Technology | System for Optically Analyzing a Test Sample and Method Therefor |
| US20230184678A1 (en) * | 2021-12-14 | 2023-06-15 | Quantum-Si Incorporated | Methods for loading and data acquisition |
| EP4463694A1 (en) * | 2022-01-12 | 2024-11-20 | Quantum-Si Incorporated | Labeled binding reagents and methods of use thereof |
| US11924963B2 (en) | 2022-02-03 | 2024-03-05 | Raytheon Company | Printed-circuit isolation barrier for co-site interference mitigation |
| EP4487103A2 (en) * | 2022-02-28 | 2025-01-08 | Bio-Rad Laboratories, Inc. | Wide-spectrum analysis system |
| CN120019439A (zh) * | 2022-03-29 | 2025-05-16 | 帕特恩电脑公司 | 用于基于光谱的疾病检测的系统和方法 |
| CA3245990A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | INTEGRATED NETWORKS FOR SINGLE-ANALYTE PROCESSES |
| WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| US12353011B2 (en) * | 2022-06-27 | 2025-07-08 | Taiwan Semiconductor Manufacturing Co., Ltd. | Photonic package and method of manufacture |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| EP4379355A1 (en) * | 2022-11-29 | 2024-06-05 | Gnothis Holding AG | High throughput analysis of single molecule events |
| WO2024124073A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | A method comprising performing on a single-analyte array at least 50 cycles of a process |
| EP4634285A1 (en) | 2022-12-15 | 2025-10-22 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| TW202440035A (zh) | 2022-12-15 | 2024-10-16 | 美商阿達普提克斯生物科學公司 | 分析物偵測之系統及方法 |
| US20240295297A1 (en) * | 2023-02-28 | 2024-09-05 | Japan Cell Co., Ltd. | Synthesized light generation method, optical characteristic converting component, light source, optical noise reduction method, measurement method, imaging method, signal processing and/or data analysis method, data analysis program, display method, communication method, service providing method, optical device, and service providing system |
| AU2024232531A1 (en) * | 2023-03-09 | 2025-09-18 | University Of Cincinnati | Optical aptamer biosensors for in-vivo sensing |
| US20240344116A1 (en) | 2023-03-24 | 2024-10-17 | Nautilus Subsidiary, Inc. | Transfer of nanoparticles to array surfaces |
| CN120981214A (zh) | 2023-04-13 | 2025-11-18 | 卢卡斯梅耶化妆品公司 | 基于木质素级分的乳化剂及其用途 |
| WO2024229244A2 (en) * | 2023-05-03 | 2024-11-07 | Mirvie, Inc. | Methods and systems for determining a pregnancy-related state of a subject |
| US20240394902A1 (en) | 2023-05-24 | 2024-11-28 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| US12373188B2 (en) | 2023-07-06 | 2025-07-29 | Bank Of America Corporation | Systems, methods, and apparatuses for improving computer energy consumption and computer processing by implementing a pluggable carbon emission gateway |
| ES2958785B2 (es) * | 2023-07-17 | 2024-07-24 | Univ Valencia Politecnica | Dispositivo de medida para el analisis de la respuesta optica de materiales biosensibles difractivos |
| WO2025043159A1 (en) | 2023-08-24 | 2025-02-27 | Nautilus Subsidiary, Inc. | Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions |
| WO2025047492A1 (ja) * | 2023-08-30 | 2025-03-06 | 富士フイルム株式会社 | 測定装置 |
| WO2025094175A1 (en) * | 2023-10-29 | 2025-05-08 | B.G. Negev Technologies And Applications Ltd. | All optical single photon detector |
| WO2025128588A1 (en) | 2023-12-11 | 2025-06-19 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| US20250205706A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| WO2025199236A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| WO2025212338A1 (en) | 2024-04-01 | 2025-10-09 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5355215A (en) * | 1992-09-30 | 1994-10-11 | Environmental Research Institute Of Michigan | Method and apparatus for quantitative fluorescence measurements |
| WO2005073407A1 (en) * | 2003-10-07 | 2005-08-11 | Ut-Battelle, Llc | Advanced integrated circuit biochip |
Family Cites Families (206)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5006716A (en) | 1989-02-22 | 1991-04-09 | Research Corporation Technologies, Inc. | Method and system for directional, enhanced fluorescence from molecular layers |
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
| JP3018687B2 (ja) * | 1991-12-12 | 2000-03-13 | 松下電器産業株式会社 | 走査型レーザー顕微鏡 |
| IL108497A0 (en) | 1993-02-01 | 1994-05-30 | Seq Ltd | Methods and apparatus for dna sequencing |
| US5495462A (en) * | 1993-06-18 | 1996-02-27 | Matsushita Electric Industrial Co., Ltd. | Light beam splitting apparatus |
| JP3169742B2 (ja) * | 1993-06-18 | 2001-05-28 | 松下電器産業株式会社 | 光分岐装置および光ディスク装置 |
| JPH07182686A (ja) * | 1993-12-21 | 1995-07-21 | Matsushita Electric Ind Co Ltd | 光モード変換装置および光分岐装置 |
| US5471515A (en) | 1994-01-28 | 1995-11-28 | California Institute Of Technology | Active pixel sensor with intra-pixel charge transfer |
| US6570617B2 (en) | 1994-01-28 | 2003-05-27 | California Institute Of Technology | CMOS active pixel sensor type imaging system on a chip |
| CN1149335A (zh) | 1994-05-27 | 1997-05-07 | 希巴-盖吉股份公司 | 探测短暂受激发光的方法 |
| US5912155A (en) | 1994-09-30 | 1999-06-15 | Life Technologies, Inc. | Cloned DNA polymerases from Thermotoga neapolitana |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| US6261797B1 (en) | 1996-01-29 | 2001-07-17 | Stratagene | Primer-mediated polynucleotide synthesis and manipulation techniques |
| US5990506A (en) | 1996-03-20 | 1999-11-23 | California Institute Of Technology | Active pixel sensors with substantially planarized color filtering elements |
| JP3748571B2 (ja) | 1996-11-18 | 2006-02-22 | ノバルティス アクチエンゲゼルシャフト | 測定装置及びその使用方法 |
| ATE273381T1 (de) | 1997-02-12 | 2004-08-15 | Eugene Y Chan | Verfahren zur analyse von polymeren |
| EP2208789B1 (en) | 1997-03-12 | 2015-07-22 | Applied Biosystems, LLC | DNA polymerases having improved labeled nucleotide incorporation properties |
| US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
| US6825921B1 (en) | 1999-11-10 | 2004-11-30 | Molecular Devices Corporation | Multi-mode light detection system |
| EP0921196A1 (en) | 1997-12-02 | 1999-06-09 | Roche Diagnostics GmbH | Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction |
| JPH11173987A (ja) | 1997-12-12 | 1999-07-02 | Hamamatsu Photonics Kk | マイクロタイタビューア |
| DE19810879A1 (de) | 1998-03-13 | 1999-09-16 | Roche Diagnostics Gmbh | Polymerasenchimären |
| WO1999049082A2 (en) | 1998-03-23 | 1999-09-30 | Invitrogen Corporation | Modified nucleotides and methods useful for nucleic acid sequencing |
| JP3813818B2 (ja) | 1998-05-01 | 2006-08-23 | アリゾナ ボード オブ リージェンツ | オリゴヌクレオチドおよびdna分子のヌクレオチド配列の決定方法 |
| US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| GB9810350D0 (en) | 1998-05-14 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
| JP2000004871A (ja) | 1998-06-29 | 2000-01-11 | Olympus Optical Co Ltd | 培養容器、及び培養容器内の試料を観察する顕微鏡 |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US6716394B2 (en) | 1998-08-11 | 2004-04-06 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
| US6210896B1 (en) | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
| US6280939B1 (en) | 1998-09-01 | 2001-08-28 | Veeco Instruments, Inc. | Method and apparatus for DNA sequencing using a local sensitive force detector |
| US6232075B1 (en) | 1998-12-14 | 2001-05-15 | Li-Cor, Inc. | Heterogeneous assay for pyrophosphate detection |
| US6134002A (en) * | 1999-01-14 | 2000-10-17 | Duke University | Apparatus and method for the rapid spectral resolution of confocal images |
| AU3174600A (en) | 1999-03-10 | 2000-09-28 | Asm Scientific, Inc. | A method for direct nucleic acid sequencing |
| GB9906929D0 (en) | 1999-03-26 | 1999-05-19 | Univ Glasgow | Assay system |
| EP1681356B1 (en) | 1999-05-19 | 2011-10-19 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| US6137117A (en) | 1999-06-21 | 2000-10-24 | The United States Of America As Represented By The Secretary Of The Navy | Integrating multi-waveguide sensor |
| FR2797053B1 (fr) * | 1999-07-13 | 2001-08-31 | Commissariat Energie Atomique | Support d'analyse a transmission de lumiere de fluorescence |
| US6596483B1 (en) * | 1999-11-12 | 2003-07-22 | Motorola, Inc. | System and method for detecting molecules using an active pixel sensor |
| US6399335B1 (en) | 1999-11-16 | 2002-06-04 | Advanced Research And Technology Institute, Inc. | γ-phosphoester nucleoside triphosphates |
| DE50006533D1 (de) * | 1999-12-17 | 2004-06-24 | Zeptosens Ag Witterswil | Anordnung von probenbehältnissen und deren verwendung zur multianalytbestimmung |
| JP3978307B2 (ja) * | 2000-02-09 | 2007-09-19 | 株式会社日立製作所 | 紫外レーザ光発生装置並びに欠陥検査装置およびその方法 |
| WO2001069211A1 (en) * | 2000-03-16 | 2001-09-20 | Spectrumedix Corporation | Multi-wavelength array reader for biological assay |
| JP2003532123A (ja) * | 2000-04-28 | 2003-10-28 | エッジライト バイオサイエンシズ インコーポレイテッド | マイクロアレーエバネッセント波蛍光検出装置 |
| US6917726B2 (en) * | 2001-09-27 | 2005-07-12 | Cornell Research Foundation, Inc. | Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes |
| AU2001268291A1 (en) | 2000-06-07 | 2001-12-17 | Li-Cor, Inc. | Charge-switch nucleotides |
| US6936702B2 (en) | 2000-06-07 | 2005-08-30 | Li-Cor, Inc. | Charge-switch nucleotides |
| WO2002001194A1 (en) | 2000-06-25 | 2002-01-03 | Affymetrix, Inc. | Optically active substrates |
| US7277166B2 (en) | 2000-08-02 | 2007-10-02 | Honeywell International Inc. | Cytometer analysis cartridge optical configuration |
| FR2813121A1 (fr) | 2000-08-21 | 2002-02-22 | Claude Weisbuch | Dispositif perfectionne de support d'elements chromophores |
| EP1320596A4 (en) | 2000-08-30 | 2005-01-12 | Univ Rochester | REVERSE TRANSCRIPTION REACTION METHOD USING REVERSE TRANSCRIPTASE CODED BY RETROTRANSPOSON NON-LTR |
| US20020031836A1 (en) | 2000-09-11 | 2002-03-14 | Feldstein Mark J. | Fluidics system |
| AU2001210599A1 (en) * | 2000-10-23 | 2002-05-06 | Diachip Limited | High precision and intellectual biochip arrayer having function of respotting |
| JP3695340B2 (ja) * | 2001-03-30 | 2005-09-14 | 株式会社日立製作所 | Dna検査方法及びその装置並びに蛍光検出方法 |
| AU2002258997A1 (en) | 2001-04-24 | 2002-11-05 | Li-Cor, Inc. | Polymerases with charge-switch activity and methods of generating such polymerases |
| US7727722B2 (en) | 2001-08-29 | 2010-06-01 | General Electric Company | Ligation amplification |
| US7256019B2 (en) | 2001-08-29 | 2007-08-14 | Ge Healthcare Bio-Sciences Corp. | Terminal phosphate blocked nucleoside polyphosphates |
| US7244566B2 (en) | 2001-08-29 | 2007-07-17 | Ge Healthcare Bio-Sciences Corp. | Analyte detection |
| US7223541B2 (en) | 2001-08-29 | 2007-05-29 | Ge Healthcare Bio-Sciences Corp. | Terminal-phosphate-labeled nucleotides and methods of use |
| US7052839B2 (en) | 2001-08-29 | 2006-05-30 | Amersham Biosciences Corp | Terminal-phosphate-labeled nucleotides and methods of use |
| JP4318296B2 (ja) | 2001-08-29 | 2009-08-19 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 標識ヌクレオシドポリホスフェート |
| US7033762B2 (en) | 2001-08-29 | 2006-04-25 | Amersham Biosciences Corp | Single nucleotide amplification and detection by polymerase |
| EP1420929B1 (de) * | 2001-08-30 | 2011-10-12 | Bayer Technology Services GmbH | Verfahren zur herstellung von abformkörpern, insbesondere optischen strukturen, und deren verwendung |
| WO2003025132A2 (en) | 2001-09-14 | 2003-03-27 | Invitrogen Corporation | Dna polymerases and mutants thereof |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| US7179654B2 (en) | 2002-03-18 | 2007-02-20 | Agilent Technologies, Inc. | Biochemical assay with programmable array detection |
| US6924887B2 (en) | 2002-03-27 | 2005-08-02 | Sarnoff Corporation | Method and apparatus for generating charge from a light pulse |
| US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
| WO2004072238A2 (en) | 2003-02-05 | 2004-08-26 | Amersham Biosciences Corp | Terminal-phosphate-labeled nucleotides with new linkers |
| US7745116B2 (en) | 2003-04-08 | 2010-06-29 | Pacific Biosciences Of California, Inc. | Composition and method for nucleic acid sequencing |
| US20040258563A1 (en) * | 2003-06-23 | 2004-12-23 | Applera Corporation | Caps for sample wells and microcards for biological materials |
| CN1209619C (zh) | 2003-07-18 | 2005-07-06 | 华中科技大学 | 塑料生物芯片的键合和封装装置 |
| WO2005016526A2 (en) * | 2003-08-04 | 2005-02-24 | Irm, Llc | Multi-well container positioning devices and related systems and methods |
| US20050079102A1 (en) | 2003-10-14 | 2005-04-14 | Staton Kenneth L. | Interrogation apparatus |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| WO2005069737A2 (en) | 2004-01-27 | 2005-08-04 | Ramot At Tel Aviv University Ltd. | Method and system for detecting analytes |
| CA2557177A1 (en) | 2004-02-19 | 2005-09-01 | Stephen Quake | Methods and kits for analyzing polynucleotide sequences |
| US7462452B2 (en) | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
| WO2006036388A2 (en) * | 2004-08-23 | 2006-04-06 | U.S. Genomics, Inc. | Systems and methods for detecting and analyzing polymers |
| WO2006044078A2 (en) | 2004-09-17 | 2006-04-27 | Pacific Biosciences Of California, Inc. | Apparatus and method for analysis of molecules |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
| US8293430B2 (en) * | 2005-01-27 | 2012-10-23 | Applied Materials, Inc. | Method for etching a molybdenum layer suitable for photomask fabrication |
| US7345764B2 (en) | 2005-02-07 | 2008-03-18 | Vladimir Bulovic | Apparatus and method for a slim format spectrometer |
| US20060223067A1 (en) | 2005-03-31 | 2006-10-05 | Paolo Vatta | Mutant DNA polymerases and methods of use |
| US7738086B2 (en) | 2005-05-09 | 2010-06-15 | The Trustees Of Columbia University In The City Of New York | Active CMOS biosensor chip for fluorescent-based detection |
| CN100401041C (zh) * | 2005-06-09 | 2008-07-09 | 上海交通大学 | 光波导吸收式气体传感器及测量系统 |
| JP2008546424A (ja) | 2005-06-28 | 2008-12-25 | アジェンコート パーソナル ジェノミクス コーポレイション | 修飾ポリヌクレオチドを作製する方法および配列決定する方法 |
| ATE501277T1 (de) | 2005-07-01 | 2011-03-15 | Dako Denmark As | Monomere und polymere linker zur konjugierung von biologischen molekülen und anderen stoffen |
| US7426322B2 (en) | 2005-07-20 | 2008-09-16 | Searete Llc. | Plasmon photocatalysis |
| WO2007094817A2 (en) * | 2005-08-02 | 2007-08-23 | University Of Utah Research Foundation | Biosensors including metallic nanocavities |
| US20160355869A1 (en) * | 2005-08-02 | 2016-12-08 | University Of Utah Research Foundation | Biosensors including metallic nanocavities |
| US7453916B2 (en) | 2005-09-08 | 2008-11-18 | Intel Corporation | High throughput optical micro-array reader capable of variable pitch and spot size array processing for genomics and proteomics |
| US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
| TWI296044B (en) * | 2005-11-03 | 2008-04-21 | Ind Tech Res Inst | Coupled waveguide-surface plasmon resonance biosensor |
| US8344121B2 (en) | 2005-12-12 | 2013-01-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nanoprobes for detection or modification of molecules |
| ATE518010T1 (de) | 2005-12-22 | 2011-08-15 | Pacific Biosciences California | Aktive oberflächengekoppelte polymerasen |
| US8921086B2 (en) | 2005-12-22 | 2014-12-30 | Pacific Biosciences Of California, Inc. | Polymerases for nucleotide analogue incorporation |
| US7692783B2 (en) | 2006-02-13 | 2010-04-06 | Pacific Biosciences Of California | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
| US7715001B2 (en) | 2006-02-13 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
| US7995202B2 (en) | 2006-02-13 | 2011-08-09 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
| US20080050747A1 (en) | 2006-03-30 | 2008-02-28 | Pacific Biosciences Of California, Inc. | Articles having localized molecules disposed thereon and methods of producing and using same |
| US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
| US7750316B2 (en) * | 2006-05-10 | 2010-07-06 | Dublin City University | Polymer biochip for detecting fluorescence |
| WO2007133710A2 (en) | 2006-05-11 | 2007-11-22 | Raindance Technologies, Inc. | Microfluidic devices and methods of use thereof |
| DE102006030541B4 (de) | 2006-06-23 | 2010-05-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Optische Anordnung |
| EP2064488B1 (en) | 2006-09-01 | 2021-10-06 | Pacific Biosciences of California, Inc. | Device and method for analyzing materials |
| US8207509B2 (en) | 2006-09-01 | 2012-06-26 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
| WO2008051530A2 (en) | 2006-10-23 | 2008-05-02 | Pacific Biosciences Of California, Inc. | Polymerase enzymes and reagents for enhanced nucleic acid sequencing |
| US9218944B2 (en) * | 2006-10-30 | 2015-12-22 | Applied Materials, Inc. | Mask etch plasma reactor having an array of optical sensors viewing the workpiece backside and a tunable element controlled in response to the optical sensors |
| FR2908888B1 (fr) | 2006-11-21 | 2012-08-03 | Centre Nat Rech Scient | Dispositif pour la detection exaltee de l'emission d'une particule cible |
| ATE509265T1 (de) | 2007-03-22 | 2011-05-15 | Univ Strasbourg Etablissement Public A Caractere Scient Culturel Et Professionel | Gerät zur sortierung und konzentration elektromagnetischer energie und vorrichtung mit mindestens einem derartigen gerät |
| EP2134871B1 (en) | 2007-03-30 | 2012-03-07 | Pacific Biosciences of California, Inc. | Systems and methods for enhancing fluorescent signals |
| JP5222599B2 (ja) * | 2007-07-20 | 2013-06-26 | 株式会社日立ハイテクノロジーズ | 核酸分析デバイス及びそれを用いた核酸分析装置 |
| JP2009022247A (ja) * | 2007-07-23 | 2009-02-05 | Toshiba Corp | 培養容器及び培養組織回収方法 |
| US9410892B2 (en) * | 2007-08-30 | 2016-08-09 | Cornell University | Nanoscale optofluidic devices for molecular detection |
| WO2009038791A1 (en) * | 2007-09-18 | 2009-03-26 | Applied Biosystems Inc. | Methods, systems and apparatus for light concentrating mechanisms |
| US7873085B2 (en) | 2007-10-23 | 2011-01-18 | Andrei Babushkin | Method and device for controlling optical output of laser diode |
| GB0723725D0 (en) | 2007-12-05 | 2008-01-16 | Ge Healthcare Uk Ltd | Apparatus and method for detecting dna damage |
| WO2009082706A1 (en) | 2007-12-21 | 2009-07-02 | The Trustees Of Columbia University In The City Of New York | Active cmos sensor array for electrochemical biomolecular detection |
| US20110165652A1 (en) | 2008-01-14 | 2011-07-07 | Life Technologies Corporation | Compositions, methods and systems for single molecule sequencing |
| EP2252625B1 (en) | 2008-02-07 | 2017-12-20 | Pacific Biosciences of California, Inc. | Cis reactive oxygen quenchers integrated into linkers |
| US8652781B2 (en) | 2008-02-12 | 2014-02-18 | Pacific Biosciences Of California, Inc. | Cognate sampling kinetics |
| EP2255014A4 (en) | 2008-02-12 | 2011-05-18 | Pacific Biosciences California | COMPOSITIONS AND METHODS FOR USE IN ANALYTICAL REACTIONS |
| US7968702B2 (en) | 2008-03-13 | 2011-06-28 | Pacific Biosciences Of California, Inc. | Labeled reactants and their uses |
| US20090243584A1 (en) * | 2008-03-25 | 2009-10-01 | Guigen Zhang | Fabrication of microstructures integrated with nanopillars along with their applications as electrodes in sensors |
| US7973146B2 (en) | 2008-03-26 | 2011-07-05 | Pacific Biosciences Of California, Inc. | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing |
| EP3045542B1 (en) | 2008-03-28 | 2016-11-16 | Pacific Biosciences of California, Inc. | Methods for nucleic acid sequencing |
| WO2009120374A2 (en) | 2008-03-28 | 2009-10-01 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
| WO2009145818A1 (en) | 2008-03-31 | 2009-12-03 | Pacific Biosciences Of California, Inc | Single molecule loading methods and compositions |
| US9127259B2 (en) | 2008-03-31 | 2015-09-08 | Pacific Biosciences Of California, Inc. | Enzymes resistant to photodamage |
| ES2614078T3 (es) | 2008-03-31 | 2017-05-29 | Pacific Biosciences Of California, Inc. | Generación de polimerasas modificadas para precisión mejorada en secuenciación de una única molécula |
| US8420366B2 (en) | 2008-03-31 | 2013-04-16 | Pacific Biosciences Of California, Inc. | Generation of modified polymerases for improved accuracy in single molecule sequencing |
| WO2009145828A2 (en) | 2008-03-31 | 2009-12-03 | Pacific Biosciences Of California, Inc. | Two slow-step polymerase enzyme systems and methods |
| US8999676B2 (en) | 2008-03-31 | 2015-04-07 | Pacific Biosciences Of California, Inc. | Recombinant polymerases for improved single molecule sequencing |
| US10114213B2 (en) | 2008-04-04 | 2018-10-30 | Cvi Laser, Llc | Laser systems and optical devices for manipulating laser beams |
| JP5268444B2 (ja) * | 2008-06-23 | 2013-08-21 | 株式会社日立ハイテクノロジーズ | 単分子リアルタイムシーケンス装置,核酸分析装置及び単分子リアルタイムシーケンス方法 |
| EP2148187A1 (de) * | 2008-07-25 | 2010-01-27 | Roche Diagnostics GmbH | Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion |
| US7999454B2 (en) * | 2008-08-14 | 2011-08-16 | Global Oled Technology Llc | OLED device with embedded chip driving |
| WO2010027484A2 (en) | 2008-09-05 | 2010-03-11 | Pacific Biosciences Of California, Inc. | Engineering polymerases and reaction conditions for modified incorporation properties |
| FR2936099A1 (fr) | 2008-09-12 | 2010-03-19 | Thales Sa | Dispositif de detection d'images ameliore pour un imageur multispectral et imageur multispectral comportant ce dispositif |
| CA2737505C (en) | 2008-09-16 | 2017-08-29 | Pacific Biosciences Of California, Inc. | Substrates and optical systems and methods of use thereof |
| US8921046B2 (en) | 2008-09-19 | 2014-12-30 | Pacific Biosciences Of California, Inc. | Nucleic acid sequence analysis |
| US8481264B2 (en) | 2008-09-19 | 2013-07-09 | Pacific Biosciences Of California, Inc. | Immobilized nucleic acid complexes for sequence analysis |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| WO2010036287A1 (en) | 2008-09-24 | 2010-04-01 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
| US8383369B2 (en) | 2008-09-24 | 2013-02-26 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
| WO2010039199A2 (en) | 2008-09-30 | 2010-04-08 | Pacific Biociences Of California, Inc. | Ultra-high multiplex analytical systems and methods |
| KR101045206B1 (ko) * | 2008-10-31 | 2011-06-30 | 삼성전자주식회사 | 여기광 흡수 도파로가 삽입된 집적된 바이오칩 및 그 제조방법 |
| EP2182523B1 (en) | 2008-10-31 | 2013-01-09 | CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement | Charge sampling device and method based on a MOS-transmission line |
| KR101065077B1 (ko) * | 2008-11-05 | 2011-09-15 | 삼성전자주식회사 | 시료 검출용 기판, 이를 채용한 바이오칩, 시료 검출용 기판의 제조방법 및 바이오 물질 검출장치 |
| WO2010057185A1 (en) | 2008-11-17 | 2010-05-20 | Pacific Biosciences Of California, Inc. | Phospholink nucleotides for sequencing applications |
| KR20110125226A (ko) | 2009-01-30 | 2011-11-18 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 혼성화 링커 |
| US8921280B2 (en) * | 2009-02-11 | 2014-12-30 | Samsung Electronics Co., Ltd. | Integrated bio-chip and method of fabricating the integrated bio-chip |
| US8603792B2 (en) | 2009-03-27 | 2013-12-10 | Life Technologies Corporation | Conjugates of biomolecules to nanoparticles |
| WO2010117420A2 (en) | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
| JP5707030B2 (ja) * | 2009-04-02 | 2015-04-22 | 株式会社日立ハイテクノロジーズ | 核酸分析デバイス、及び核酸分析装置 |
| US8501406B1 (en) | 2009-07-14 | 2013-08-06 | Pacific Biosciences Of California, Inc. | Selectively functionalized arrays |
| JP5462548B2 (ja) * | 2009-08-12 | 2014-04-02 | 株式会社日立ハイテクノロジーズ | 核酸分析素子及びそれを用いた核酸分析装置 |
| WO2011040971A2 (en) | 2009-09-30 | 2011-04-07 | Pacific Biosciences Of California, Inc. | Generation of modified polymerases for improved accuracy in single molecule sequencing |
| US8278728B2 (en) | 2009-10-17 | 2012-10-02 | Florida Institute Of Technology | Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels |
| WO2011068569A1 (en) | 2009-12-04 | 2011-06-09 | Biotium, Inc. | Heterocycle-substituted xanthene dyes |
| JP6017107B2 (ja) | 2009-12-28 | 2016-10-26 | ソニー株式会社 | イメージセンサ及びその製造方法、並びにセンサデバイス |
| WO2011090745A1 (en) | 2009-12-29 | 2011-07-28 | Life Technologies Corporation | Single molecule detection and sequencing using fluorescence lifetime imaging |
| US8994946B2 (en) | 2010-02-19 | 2015-03-31 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method |
| US8467061B2 (en) | 2010-02-19 | 2013-06-18 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method |
| US9482615B2 (en) * | 2010-03-15 | 2016-11-01 | Industrial Technology Research Institute | Single-molecule detection system and methods |
| TWI466278B (zh) | 2010-04-06 | 2014-12-21 | 勝開科技股份有限公司 | 晶圓級影像感測器構裝結構及其製造方法 |
| US8865077B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| US8865078B2 (en) * | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| EP2439512A1 (en) * | 2010-10-01 | 2012-04-11 | Aqsens Oy | A device for holding a sample |
| EP2441520A1 (en) | 2010-10-12 | 2012-04-18 | Eppendorf AG | Real-time amplification and micro-array based detection of nucleic acid targets in a flow chip assay |
| CN103380500B (zh) | 2010-11-30 | 2015-12-09 | 茨瓦内科技大学 | 基于cmos的微光子系统 |
| EP2646154A2 (en) | 2010-11-30 | 2013-10-09 | Quantumdx Group Limited | The design, fabrication and use of a microfluidics multitemperature flexible reaction device |
| WO2012129242A2 (en) | 2011-03-23 | 2012-09-27 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
| JP2013045857A (ja) | 2011-08-24 | 2013-03-04 | Sony Corp | イメージセンサ及びその製造方法並びに検査装置 |
| FR2982028B1 (fr) | 2011-10-26 | 2020-02-21 | Aryballe Technologies | Puce microstructuree comprenant des surfaces convexes pour analyse par resonance des plasmons de surface, dispositif d'analyse contenant ladite puce microstructuree et utilisation dudit dispositif |
| US8778849B2 (en) | 2011-10-28 | 2014-07-15 | Illumina, Inc. | Microarray fabrication system and method |
| US9606060B2 (en) | 2012-01-13 | 2017-03-28 | California Institute Of Technology | Filterless time-domain detection of one or more fluorophores |
| US8906660B2 (en) | 2012-02-01 | 2014-12-09 | Pacific Biosciences Of California, Inc. | Recombinant polymerases with increased phototolerance |
| EP3222627B1 (en) | 2012-02-15 | 2019-08-07 | Pacific Biosciences of California, Inc. | Polymerase enzyme substrates with protein shield |
| US9059250B2 (en) * | 2012-02-17 | 2015-06-16 | International Business Machines Corporation | Lateral-dimension-reducing metallic hard mask etch |
| WO2013148400A1 (en) * | 2012-03-30 | 2013-10-03 | Pacific Biosciences Of California, Inc. | Methods and composition for sequencing modified nucleic acids |
| CN104380084A (zh) * | 2012-04-10 | 2015-02-25 | 普林斯顿大学理事会 | 超灵敏传感器 |
| WO2013171197A1 (en) | 2012-05-15 | 2013-11-21 | Ait Austrian Institute Of Technology Gmbh | Compact plasmon-enhanced fluorescence biosensor |
| US9372308B1 (en) | 2012-06-17 | 2016-06-21 | Pacific Biosciences Of California, Inc. | Arrays of integrated analytical devices and methods for production |
| US8654427B1 (en) | 2012-08-31 | 2014-02-18 | Rosemount Aerospace Inc. | Ruggedized two-axis optical beam steering device |
| US9223084B2 (en) | 2012-12-18 | 2015-12-29 | Pacific Biosciences Of California, Inc. | Illumination of optical analytical devices |
| EP2959283B1 (en) * | 2013-02-22 | 2022-08-17 | Pacific Biosciences of California, Inc. | Integrated illumination of optical analytical devices |
| JP2016522676A (ja) | 2013-03-15 | 2016-08-04 | ナノバイオシム・インコーポレイテッド | 核酸及びタンパク質の移動式デバイス分析のためのシステム及び方法 |
| US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
| US9654680B2 (en) * | 2013-10-17 | 2017-05-16 | Canon Kabushiki Kaisha | Image capturing apparatus and control method therefor |
| CN110452809B (zh) | 2013-11-17 | 2022-07-01 | 宽腾矽公司 | 与测定芯片通过接口连接的仪器 |
| WO2015141873A1 (ko) | 2014-03-18 | 2015-09-24 | 서울대학교산학협력단 | 광영역 시료를 고속 정량 분석하는 라만 분석 방법 및 장치 |
| US9765395B2 (en) | 2014-04-28 | 2017-09-19 | Nanomedical Diagnostics, Inc. | System and method for DNA sequencing and blood chemistry analysis |
| AU2015300766B2 (en) | 2014-08-08 | 2021-02-04 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
| CN112903639B (zh) | 2014-08-08 | 2022-09-13 | 宽腾矽公司 | 用于对分子进行探测、检测和分析的带外部光源的集成装置 |
| BR112017002489B1 (pt) | 2014-08-08 | 2023-02-14 | Quantum-Si Incorporated | Instrumento configurado para fazer interface com um chip de teste, aparelho, método de análise de um espécime, método para sequenciar uma molécula-alvo de ácido nucleico e método para sequenciamento de ácido nucleico |
| US9666748B2 (en) | 2015-01-14 | 2017-05-30 | International Business Machines Corporation | Integrated on chip detector and zero waveguide module structure for use in DNA sequencing |
| CN113064236B (zh) | 2015-03-16 | 2022-11-01 | 加利福尼亚太平洋生物科学股份有限公司 | 用于自由空间光耦合的集成装置及系统 |
| US10246742B2 (en) | 2015-05-20 | 2019-04-02 | Quantum-Si Incorporated | Pulsed laser and bioanalytic system |
| US10605730B2 (en) | 2015-05-20 | 2020-03-31 | Quantum-Si Incorporated | Optical sources for fluorescent lifetime analysis |
| CN105039147B (zh) | 2015-06-03 | 2016-05-04 | 西安交通大学 | 一种高通量基因测序碱基荧光图像捕获系统装置及方法 |
| WO2019023174A1 (en) | 2017-07-24 | 2019-01-31 | Quantum-Si Incorporated | MASSIVELY PARALLEL BIO-OPTOELECTRONIC INSTRUMENT HAND-HELD |
-
2014
- 2014-11-17 CN CN201910752352.5A patent/CN110452809B/zh active Active
- 2014-11-17 MX MX2016006454A patent/MX381541B/es unknown
- 2014-11-17 AU AU2014348306A patent/AU2014348306B2/en active Active
- 2014-11-17 JP JP2016554539A patent/JP6673843B2/ja not_active Expired - Fee Related
- 2014-11-17 CN CN201480073505.9A patent/CN105980580B/zh active Active
- 2014-11-17 CA CA2930836A patent/CA2930836A1/en active Pending
- 2014-11-17 JP JP2016554540A patent/JP6573899B2/ja active Active
- 2014-11-17 US US14/543,865 patent/US10048208B2/en active Active
- 2014-11-17 AU AU2014348305A patent/AU2014348305B2/en active Active
- 2014-11-17 US US14/543,867 patent/US9863880B2/en active Active
- 2014-11-17 KR KR1020167016352A patent/KR102221637B1/ko not_active Expired - Fee Related
- 2014-11-17 AU AU2014348302A patent/AU2014348302B2/en active Active
- 2014-11-17 MX MX2016006453A patent/MX378010B/es unknown
- 2014-11-17 KR KR1020217005386A patent/KR102399962B1/ko active Active
- 2014-11-17 EP EP20150534.4A patent/EP3709003A1/en not_active Withdrawn
- 2014-11-17 KR KR1020167016350A patent/KR102240166B1/ko active Active
- 2014-11-17 CN CN201480073365.5A patent/CN106029904A/zh active Pending
- 2014-11-17 CA CA2930832A patent/CA2930832A1/en not_active Abandoned
- 2014-11-17 WO PCT/US2014/066013 patent/WO2015074004A1/en not_active Ceased
- 2014-11-17 KR KR1020167016349A patent/KR102296713B1/ko active Active
- 2014-11-17 MX MX2016006455A patent/MX380165B/es unknown
- 2014-11-17 CN CN201480073394.1A patent/CN105917003A/zh active Pending
- 2014-11-17 JP JP2016554541A patent/JP2016537999A/ja active Pending
- 2014-11-17 MX MX2020013247A patent/MX392471B/es unknown
- 2014-11-17 BR BR112016011084A patent/BR112016011084B8/pt active IP Right Grant
- 2014-11-17 CA CA2930834A patent/CA2930834A1/en active Pending
- 2014-11-17 BR BR112016011052-8A patent/BR112016011052B1/pt active IP Right Grant
- 2014-11-17 EP EP14809194.5A patent/EP3068900B1/en active Active
- 2014-11-17 EP EP20150539.3A patent/EP3715831A1/en not_active Withdrawn
- 2014-11-17 WO PCT/US2014/066014 patent/WO2015074005A1/en not_active Ceased
- 2014-11-17 BR BR112016011061-7A patent/BR112016011061B1/pt active IP Right Grant
- 2014-11-17 WO PCT/US2014/066010 patent/WO2015074001A1/en not_active Ceased
- 2014-11-17 EP EP21203429.2A patent/EP3974814A1/en not_active Withdrawn
- 2014-11-17 EP EP14812051.2A patent/EP3068901B1/en active Active
- 2014-11-17 CN CN202010074109.5A patent/CN111235246B/zh active Active
- 2014-11-17 US US14/543,888 patent/US9983135B2/en active Active
- 2014-11-17 EP EP14812050.4A patent/EP3074531B1/en active Active
-
2017
- 2017-11-10 US US15/808,940 patent/US10533945B2/en active Active
-
2018
- 2018-04-24 US US15/960,751 patent/US10712273B2/en active Active
- 2018-05-09 US US15/974,826 patent/US10712274B2/en active Active
- 2018-07-05 US US16/028,159 patent/US11428635B2/en active Active
-
2019
- 2019-11-19 US US16/689,004 patent/US11287382B2/en active Active
-
2020
- 2020-03-05 JP JP2020037466A patent/JP7015336B2/ja not_active Expired - Fee Related
- 2020-06-12 US US16/900,008 patent/US12123834B2/en active Active
- 2020-12-11 AU AU2020286308A patent/AU2020286308B2/en active Active
-
2021
- 2021-02-08 JP JP2021018615A patent/JP7242727B2/ja active Active
-
2022
- 2022-02-18 US US17/676,070 patent/US12163888B2/en active Active
- 2022-03-25 US US17/704,691 patent/US20220214279A1/en not_active Abandoned
- 2022-07-29 US US17/877,837 patent/US20220364996A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5355215A (en) * | 1992-09-30 | 1994-10-11 | Environmental Research Institute Of Michigan | Method and apparatus for quantitative fluorescence measurements |
| WO2005073407A1 (en) * | 2003-10-07 | 2005-08-11 | Ut-Battelle, Llc | Advanced integrated circuit biochip |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105980580B (zh) | 用于探测、检测和分析分子的光学系统和测定芯片 | |
| CN106796175B (zh) | 用于探测、检测和分析分子的光学系统和检测芯片 | |
| HK40037505A (en) | Optical system and assay chip for probing, detecting and analyzing molecules | |
| HK40038443A (en) | Active-source-pixel, integrated device for rapid analysis of biological and chemical speciments | |
| HK1228964B (en) | Optical system and assay chip for probing, detecting and analyzing molecules | |
| HK1228964A1 (en) | Optical system and assay chip for probing, detecting and analyzing molecules | |
| HK1228962A1 (en) | Active-source-pixel, integrated device for rapid analysis of biological and chemical speciments | |
| HK1228962B (en) | Active-source-pixel, integrated device for rapid analysis of biological and chemical speciments |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |