AU2014348306B2 - Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens - Google Patents

Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens Download PDF

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Publication number
AU2014348306B2
AU2014348306B2 AU2014348306A AU2014348306A AU2014348306B2 AU 2014348306 B2 AU2014348306 B2 AU 2014348306B2 AU 2014348306 A AU2014348306 A AU 2014348306A AU 2014348306 A AU2014348306 A AU 2014348306A AU 2014348306 B2 AU2014348306 B2 AU 2014348306B2
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sample well
excitation
sample
layer
implementations
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AU2014348306A1 (en
Inventor
Brett J. Gyarfas
Ali KABIRI
Jeremy Lackey
Jonathan M. Rothberg
Gerard Schmid
Jason W. Sickler
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Quantum Si Inc
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Quantum Si Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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    • G—PHYSICS
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
AU2014348306A 2013-11-17 2014-11-17 Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens Ceased AU2014348306B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361905282P 2013-11-17 2013-11-17
US61/905,282 2013-11-17
US201361917926P 2013-12-18 2013-12-18
US61/917,926 2013-12-18
US201461941916P 2014-02-19 2014-02-19
US61/941,916 2014-02-19
PCT/US2014/066014 WO2015074005A1 (en) 2013-11-17 2014-11-17 Active-source-pixel, integrated device for rapid analysis of biological and chemical speciments

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AU2014348306A1 AU2014348306A1 (en) 2016-06-16
AU2014348306B2 true AU2014348306B2 (en) 2020-11-12

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AU2014348306A Ceased AU2014348306B2 (en) 2013-11-17 2014-11-17 Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens
AU2014348302A Ceased AU2014348302B2 (en) 2013-11-17 2014-11-17 Optical system and assay chip for probing, detecting and analyzing molecules
AU2014348305A Ceased AU2014348305B2 (en) 2013-11-17 2014-11-17 Integrated device with external light source for probing detecting and analyzing molecules
AU2020286308A Ceased AU2020286308B2 (en) 2013-11-17 2020-12-11 Optical system and assay chip for probing, detecting and analyzing molecules

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AU2014348302A Ceased AU2014348302B2 (en) 2013-11-17 2014-11-17 Optical system and assay chip for probing, detecting and analyzing molecules
AU2014348305A Ceased AU2014348305B2 (en) 2013-11-17 2014-11-17 Integrated device with external light source for probing detecting and analyzing molecules
AU2020286308A Ceased AU2020286308B2 (en) 2013-11-17 2020-12-11 Optical system and assay chip for probing, detecting and analyzing molecules

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US (12) US10048208B2 (enExample)
EP (6) EP3709003A1 (enExample)
JP (5) JP2016537999A (enExample)
KR (4) KR102240166B1 (enExample)
CN (5) CN105917003A (enExample)
AU (4) AU2014348306B2 (enExample)
BR (3) BR112016011084B8 (enExample)
CA (3) CA2930836A1 (enExample)
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Families Citing this family (210)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9593371B2 (en) 2013-12-27 2017-03-14 Intel Corporation Integrated photonic electronic sensor arrays for nucleic acid sequencing
EP3709003A1 (en) 2013-11-17 2020-09-16 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecules
WO2015117157A1 (en) * 2014-02-03 2015-08-06 Electromagnetic Landmarks Inc. Magnetic sensor array and system
US11287484B2 (en) 2014-02-03 2022-03-29 Innovaura Corporation Method and apparatus for triage of electronic items using magnetic field detection
US11747407B2 (en) 2014-02-03 2023-09-05 Innovaura Corporation System and method for characterizing defects in electronic items using magnetic field detection
CN111710687B (zh) 2014-08-08 2023-11-14 宽腾矽公司 基于入射光子到达时间的识别、成像、测序法及存储介质
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
US12655467B2 (en) 2014-08-08 2026-06-16 Quantum-Si Incorporated Methods for nucleic acid sequencing
US9885657B2 (en) 2014-08-08 2018-02-06 Quantum-Si Incorporated Integrated device with external light source for probing detecting and analyzing molecules
KR102738114B1 (ko) * 2014-08-08 2024-12-06 퀀텀-에스아이 인코포레이티드 분자들을 프로빙, 검출 및 분석하기 위한 광학계 및 검정 칩
US9721751B2 (en) * 2014-08-22 2017-08-01 The Board Of Trustees Of The Leland Stanford Junior University Electron microscopy specimen and method of fabrication
US9506908B2 (en) 2014-10-06 2016-11-29 Alveo Technologies, Inc. System for detection of analytes
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
US10352899B2 (en) 2014-10-06 2019-07-16 ALVEO Technologies Inc. System and method for detection of silver
US9921182B2 (en) 2014-10-06 2018-03-20 ALVEO Technologies Inc. System and method for detection of mercury
US10627358B2 (en) 2014-10-06 2020-04-21 Alveo Technologies, Inc. Method for detection of analytes
US10184892B2 (en) * 2014-10-29 2019-01-22 Horiba Instruments Incorporated Determination of water treatment parameters based on absorbance and fluorescence
TR201910871T4 (tr) * 2015-01-20 2019-08-21 Hyris Ltd Sıvı bir numunede floresans ölçümü için dedektör.
US10018608B2 (en) * 2015-02-27 2018-07-10 Vitaly Talyansky System to authenticate and identify items
CN113064236B (zh) 2015-03-16 2022-11-01 加利福尼亚太平洋生物科学股份有限公司 用于自由空间光耦合的集成装置及系统
US11466316B2 (en) 2015-05-20 2022-10-11 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10605730B2 (en) 2015-05-20 2020-03-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
US9874693B2 (en) 2015-06-10 2018-01-23 The Research Foundation For The State University Of New York Method and structure for integrating photonics with CMOs
AU2016276980B2 (en) 2015-06-12 2021-09-23 Pacific Biosciences Of California, Inc. Integrated target waveguide devices and systems for optical coupling
TWI697674B (zh) * 2015-07-27 2020-07-01 體學生物科技股份有限公司 感測模組及感測方法
WO2017019768A1 (en) * 2015-07-30 2017-02-02 The Regents Of The University Of California Optical cavity pcr
EP3344976A4 (en) * 2015-08-18 2019-03-20 Agency For Science, Technology And Research OPTICAL STRUCTURE AND OPTICAL LIGHT DETECTION SYSTEM
US9733188B2 (en) * 2015-09-21 2017-08-15 International Business Machines Corporation Enhancing on-chip fluorescence detection
US11320373B2 (en) 2015-10-22 2022-05-03 Jacob Schneiderman Systems and methods for identifying and treating biological materials
KR101720434B1 (ko) * 2015-11-10 2017-03-28 한국과학기술원 광 위상배열 안테나
US10248838B2 (en) * 2015-12-04 2019-04-02 The Regents Of The University Of California Method and device for single molecule imaging
US10352856B2 (en) * 2015-12-14 2019-07-16 Massachusetts Institute Of Technology Apparatus and methods for spectroscopy and broadband light emission using two-dimensional plasmon fields
US10497682B2 (en) 2016-01-12 2019-12-03 Apple Inc. Backplane LED integration and functionalization structures
JP7109785B2 (ja) 2016-01-14 2022-08-01 ロズウェル バイオテクノロジーズ，インコーポレイテッド 分子センサーおよび関連方法
US10712334B2 (en) 2016-01-28 2020-07-14 Roswell Biotechnologies, Inc. Massively parallel DNA sequencing apparatus
EP3408220A4 (en) * 2016-01-28 2019-09-04 Roswell Biotechnologies, Inc METHOD AND DEVICE FOR MEASURING ANALYTES USING LARGE CALCULAR MOLECULAR ELECTRONIC SENSOR ARRAYS
US10737263B2 (en) 2016-02-09 2020-08-11 Roswell Biotechnologies, Inc. Electronic label-free DNA and genome sequencing
TW202139919A (zh) 2016-02-17 2021-11-01 美商太斯萊特健康股份有限公司 用於生命期成像及偵測應用之感測器及裝置
US10597767B2 (en) 2016-02-22 2020-03-24 Roswell Biotechnologies, Inc. Nanoparticle fabrication
EP3433017A4 (en) * 2016-03-25 2020-01-01 Bioceryx Inc. APPARATUSES AND METHODS FOR EVALUATING NUMBERS OF TARGET SEQUENCES
EP3446157B1 (en) 2016-04-22 2023-05-17 Illumina, Inc. Photonic stucture-based devices and compositions for use in luminescent imaging of multiple sites within a pixel, and methods of using the same
US10451518B2 (en) * 2016-05-10 2019-10-22 Rd2, Llc All fiber temperature and air density sensor
WO2017205868A1 (en) * 2016-05-27 2017-11-30 Singulex, Inc. Camera-based single molecule reader
US11529213B2 (en) 2016-05-30 2022-12-20 David Akselrod Backscatter device-based dental imaging apparatus
US11389277B2 (en) 2016-07-18 2022-07-19 David Akselrod Material property monitoring using backscatter devices
EP4009330A1 (en) * 2016-06-01 2022-06-08 Quantum-si Incorporated Pulse caller and base caller
KR102627237B1 (ko) * 2016-06-01 2024-01-23 퀀텀-에스아이 인코포레이티드 분자들을 검출 및 분석하기 위한 통합 디바이스
US10758153B2 (en) * 2016-07-18 2020-09-01 David Akselrod Material property monitoring and detection using wireless devices
US9829456B1 (en) 2016-07-26 2017-11-28 Roswell Biotechnologies, Inc. Method of making a multi-electrode structure usable in molecular sensing devices
US11386552B2 (en) 2016-08-01 2022-07-12 Genprime, Inc. System and method to interpret tests that change color to indicate the presence or non-presence of a compound
US10656088B2 (en) * 2016-08-12 2020-05-19 Silanna UV Technologies Pte Ltd Ultraviolet biosensor
EP3285052A1 (en) 2016-08-19 2018-02-21 IMEC vzw Photonic circuit with integrated light coupler
AU2017330304A1 (en) 2016-09-23 2019-04-11 Alveo Technologies, Inc. Methods and compositions for detecting analytes
BR112019008939B1 (pt) 2016-11-03 2023-11-07 Mgi Tech Co., Ltd Biossensor, método, e, método para sequenciamento de dna
FR3058521B1 (fr) * 2016-11-08 2021-01-08 Univ Montpellier Dispositif et procede de detection de presence de molecules determinees, biocapteur
JP6770197B2 (ja) * 2016-12-15 2020-10-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 適応ナノ細孔信号圧縮
KR102805796B1 (ko) 2016-12-16 2025-05-15 퀀텀-에스아이 인코포레이티드 콤팩트한 빔 셰이핑 및 스티어링 어셈블리
JP2018100959A (ja) * 2016-12-16 2018-06-28 シャープ株式会社 検出器、ならびに、検出器の校正方法、補正方法、検出装置
EP3555972A1 (en) 2016-12-16 2019-10-23 Quantum-si Incorporated Compact mode-locked laser module
MX2019007247A (es) 2016-12-19 2019-08-16 Quantum Si Inc Carga de moleculas en pocillos para muestra para su analisis.
CN110168732B (zh) 2016-12-22 2024-03-08 宽腾矽公司 具有直接合并像素的整合式光电侦测器
CN110431148A (zh) 2017-01-10 2019-11-08 罗斯威尔生命技术公司 用于dna数据存储的方法和系统
KR102685937B1 (ko) 2017-01-19 2024-07-17 로스웰 엠이 아이엔씨. 2차원 레이어 재료를 포함하는 솔리드 스테이트 시퀀싱 디바이스들
US11419703B2 (en) 2017-01-27 2022-08-23 David Akselrod Orthodontic braces and feet orthotics with backscatter based sensors
KR101847334B1 (ko) * 2017-02-02 2018-04-10 한국기초과학지원연구원 형광 이미지 획득 장치 및 방법
GB201701829D0 (en) * 2017-02-03 2017-03-22 Norwegian Univ Of Science And Tech (Ntnu) Device
CA3052809A1 (en) * 2017-02-08 2018-08-23 Essenlix Corporation Qmax assays and applications
EP3595806A4 (en) * 2017-03-17 2021-06-16 Apton Biosystems, Inc. SEQUENCING AND HIGH RESOLUTION IMAGING
KR102535751B1 (ko) 2017-03-20 2023-05-22 엠쥐아이 테크 컴퍼니 엘티디. 생물학적 또는 화학적 분석을 위한 바이오센서 및 그 제조 방법
KR102692957B1 (ko) 2017-04-25 2024-08-06 로스웰 엠이 아이엔씨. 분자 센서들을 위한 효소 회로들
JP7356909B2 (ja) 2017-05-05 2023-10-05 クアンタム－エスアイ インコーポレイテッド 生物学的反応における表面反応性と防汚特性が改変された基板
CN110651182B (zh) 2017-05-09 2022-12-30 罗斯威尔生命技术公司 用于分子传感器的结合探针电路
EP4191236A1 (en) * 2017-05-23 2023-06-07 Hamamatsu Photonics K.K. Orientation characteristic measurement method, orientation characteristic measurement program, and orientation characteristic measurement device
KR102795781B1 (ko) * 2017-06-16 2025-04-15 듀크 유니버시티 개선된 라벨 검출, 계산, 분석물 감지, 및 조정 가능한 난수 생성을 위한 공진기 네트워크
CN109103090B (zh) * 2017-06-21 2020-12-04 清华大学 纳米带的制备方法
KR102083396B1 (ko) * 2017-06-28 2020-03-02 주식회사 파나진 양자점을 분산광원으로 하는 표적 핵산 검출 방법
CN107390172B (zh) * 2017-07-17 2020-04-28 北京大学 一种无接触感知定位方法
CN111133294B (zh) * 2017-07-24 2024-05-24 宽腾矽公司 光抑制光子结构
CA3069983A1 (en) 2017-07-24 2019-01-31 Quantum-Si Incorporated Hand-held, massively-parallel, bio-optoelectronic instrument
CN107402199B (zh) * 2017-07-31 2019-09-10 京东方科技集团股份有限公司 基因测序芯片及其测序方法以及基因测序装置
WO2019036055A2 (en) 2017-08-18 2019-02-21 Ignite Biosciences, Inc. METHODS OF SELECTING BINDING REAGENTS
EP3676389A4 (en) 2017-08-30 2021-06-02 Roswell Biotechnologies, Inc PROCESSIVE ENZYMATIC MOLECULAR ELECTRONIC SENSORS FOR STORING DNA DATA
WO2019060177A1 (en) 2017-09-19 2019-03-28 Complete Genomics, Inc. MANUFACTURE OF SEQUENCING FLOW CELLS AT THE WAFER
WO2019075100A1 (en) 2017-10-10 2019-04-18 Roswell Biotechnologies, Inc. METHODS, APPARATUS AND SYSTEMS FOR STORING DNA DATA WITHOUT AMPLIFICATION
EP3501651B1 (en) * 2017-12-22 2024-03-06 IMEC vzw Microfluidic routing
KR102509385B1 (ko) * 2018-01-08 2023-03-14 퀀텀-에스아이 인코포레이티드 서브-미크론-스케일 반응 챔버들의 전기동역학적 로딩을 위한 시스템 및 방법
KR102370055B1 (ko) 2018-01-08 2022-03-03 일루미나, 인코포레이티드 반도체-기반 검출을 사용하는 고-처리율 서열분석용 시스템 및 디바이스
CN108197052B (zh) * 2018-01-17 2021-02-26 上海聚星仪器有限公司 一种新型测试测量仪器
BR112020014542A2 (pt) 2018-01-26 2020-12-08 Quantum-Si Incorporated Aprendizado de máquina habilitado por aplicação de pulso e de base para dispositivos de sequenciamento
IT201800004146A1 (it) * 2018-03-30 2019-09-30 St Microelectronics Srl Apparecchio di analisi di molecole tramite rilevamento di segnali fluorescenti e relativo metodo
US10965102B2 (en) * 2018-04-12 2021-03-30 Samsung Electronics Co., Ltd. Structured light projector and electronic apparatus including the same
EP3581919B1 (en) * 2018-06-15 2022-03-23 IMEC vzw An imaging apparatus and a method for imaging an object
EP3807622A1 (en) 2018-06-15 2021-04-21 Quantum-Si Incorporated Data acquisition control for advanced analytic instruments having pulsed optical sources
KR102546320B1 (ko) * 2018-06-18 2023-06-22 삼성전자주식회사 구조광 프로젝터 및 이를 포함하는 전자 장치
MX2020013788A (es) 2018-06-22 2021-03-02 Quantum Si Inc Fotodetector integrado con deposito de almacenamiento de carga con tiempo de deteccion variado.
WO2020023496A1 (en) * 2018-07-23 2020-01-30 The University Of Chicago Resonator-based ion-selective sensor
JP7428701B2 (ja) * 2018-08-29 2024-02-06 クアンタム－エスアイ インコーポレイテッド サンプルウェル作製技法および集積センサデバイス用の構造
EP3844486A1 (en) * 2018-08-29 2021-07-07 Quantum-Si Incorporated System and methods for detecting lifetime using photon counting photodetectors
JP6906489B2 (ja) 2018-09-14 2021-07-21 株式会社東芝 ケミカルセンサキット及び分析方法
US11509116B2 (en) * 2018-10-23 2022-11-22 Analog Photonics LLC Athermal angular output by combining a laser with a grating based antenna
CN111135878B (zh) * 2018-11-06 2021-10-15 京东方科技集团股份有限公司 微流体通道结构及制作方法、微流体检测装置及使用方法
WO2020094233A1 (de) * 2018-11-08 2020-05-14 Diamontech Ag Vorrichtung und verfahren zum analysieren eines stoffs
TWI863941B (zh) 2018-11-15 2024-12-01 美商寬騰矽公司 用於蛋白質定序之方法及組合物
JP2022513092A (ja) 2018-11-20 2022-02-07 ノーティラス・バイオテクノロジー・インコーポレイテッド 親和性試薬の設計および選択
JP2020085666A (ja) * 2018-11-26 2020-06-04 ソニーセミコンダクタソリューションズ株式会社 生体由来物質検出用チップ、生体由来物質検出装置及び生体由来物質検出システム
US12179204B2 (en) 2018-12-03 2024-12-31 Quantum-Si Incorporated Sample well fabrication techniques and structures for integrated sensor
AU2019401601B2 (en) 2018-12-20 2026-04-02 Alveo Technologies, Inc. Handheld impedance-based diagnostic test system for detecting analytes
MX2021008133A (es) * 2019-01-03 2021-08-11 Quantum Si Inc Guias de ondas opticas y acopladores para suministrar luz a un conjunto de elementos fotonicos.
TWI687687B (zh) * 2019-01-11 2020-03-11 國立中正大學 雙光柵感測器、檢測方法及其製備方法
AU2020233571B2 (en) * 2019-03-04 2025-05-22 Immunolight, Llc Energy augmentation structures for use with energy emitters and collectors
CN113544493A (zh) * 2019-03-05 2021-10-22 宽腾矽公司 用于集成装置的光学吸收滤光器
EP4648576A3 (en) 2019-03-08 2026-01-28 Infinite Potential Laboratories LP Quantum control devices and methods
CN113597558B (zh) 2019-03-20 2024-12-10 启正生命科学有限公司 用于验证生物分析仪的标准材料组合物和使用其的标准条带
US12504396B2 (en) 2019-04-12 2025-12-23 SemiconBio Polycyclic aromatic bridges for molecular electronic sensors
US11534755B2 (en) 2019-04-16 2022-12-27 Boe Technology Group Co., Ltd. Micro-channel device and manufacturing method thereof and micro-fluidic system
AU2020266136B2 (en) 2019-04-29 2026-04-02 Nautilus Subsidiary, Inc. Methods and systems for integrated on-chip single-molecule detection
CN110066723A (zh) * 2019-05-05 2019-07-30 京东方科技集团股份有限公司 基因测序芯片、设备、制造方法
AU2020294144A1 (en) 2019-06-14 2022-01-27 Quantum-Si Incorporated Sliced grating coupler with increased beam alignment sensitivity
US11009611B2 (en) 2019-06-18 2021-05-18 Eagle Technology, Llc Radiation detection system with surface plasmon resonance detection and related methods
CN110229747B (zh) * 2019-06-18 2026-07-14 京东方科技集团股份有限公司 基因测序芯片、设备及制备方法
US11085878B2 (en) 2019-06-18 2021-08-10 Eagle Technology, Llc Radiation detection system with surface plasmon resonance detection and related methods
CA3144003A1 (en) 2019-06-19 2020-12-24 Quantum-Si Incorporated Optical nanostructure rejecter for an integrated device and related methods
US11360028B2 (en) * 2019-06-20 2022-06-14 Cilag Gmbh International Super resolution and color motion artifact correction in a pulsed hyperspectral, fluorescence, and laser mapping imaging system
US11793399B2 (en) 2019-06-20 2023-10-24 Cilag Gmbh International Super resolution and color motion artifact correction in a pulsed hyperspectral imaging system
US12284455B2 (en) * 2019-06-26 2025-04-22 Sony Group Corporation Optical measurement device and optical measurement system
CN113330297A (zh) * 2019-07-08 2021-08-31 伊鲁米纳公司 波导与光检测设备上的光学耦合结构的集成
EP3996846A4 (en) 2019-07-09 2023-10-18 Kryptos Biotechnologies, Inc. Microfluidic reaction vessel array with patterned films
AU2020326781A1 (en) 2019-08-08 2022-03-17 Quantum-Si Incorporated Increased emission collection efficiency in integrated optical devices
US12252582B2 (en) 2019-08-29 2025-03-18 University Of Delaware Biofunctional thiophene monomers and polymers thereof for electronic biomedical devices
WO2021045900A1 (en) 2019-09-06 2021-03-11 Roswell Biotechnologies, Inc. Methods of fabricating nanoscale structures usable in molecular sensors and other devices
US10957731B1 (en) * 2019-10-04 2021-03-23 Visera Technologies Company Limited Sensor device and method for manufacturing the same
US11630062B2 (en) * 2019-10-10 2023-04-18 Visera Technologies Company Limited Biosensor and method of forming the same
US11105745B2 (en) * 2019-10-10 2021-08-31 Visera Technologies Company Limited Biosensor
US11705472B2 (en) 2019-10-10 2023-07-18 Visera Technologies Company Limited Biosensor and method of distinguishing a light
CN114829669B (zh) 2019-10-11 2024-10-01 宽腾矽公司 气相表面改性
EP4051903A1 (en) 2019-10-29 2022-09-07 Quantum-Si Incorporated Peristaltic pumping of fluids and associated methods, systems, and devices
TWI704342B (zh) * 2019-11-28 2020-09-11 雷科股份有限公司 Aoi(自動光學檢測)應用在雷射蝕薄銅線圈的方法及其設備
US12514685B2 (en) 2019-12-13 2026-01-06 David Akselrod Orthodontic braces and feet orthotics with backscatter based sensors
KR102351249B1 (ko) * 2020-01-03 2022-01-14 한국과학기술원 분자 다중 이미징 방법 및 장치
US11703454B2 (en) 2020-01-03 2023-07-18 Korea Advanced Institute Of Science And Technology Method and apparatus for multiplexed imaging of spectrally-similar fluorophores
US11784416B2 (en) * 2020-01-06 2023-10-10 Raytheon Company Tunable radio frequency (RF) absorber and thermal heat spreader
AU2021208557A1 (en) 2020-01-14 2022-09-01 Quantum-Si Incorporated Sensor for lifetime plus spectral characterization
CA3168138A1 (en) 2020-01-14 2021-07-22 Quantum-Si Incorporated Integrated sensor for lifetime characterization
IL294734A (en) 2020-01-14 2022-09-01 Quantum Si Inc Amplitude-modulated laser
WO2021150984A1 (en) * 2020-01-24 2021-07-29 Deepdivebio, Inc. Optical array qpcr
CN111308530B (zh) * 2020-02-17 2021-12-03 中国人民解放军战略支援部队信息工程大学 一种基于二维波达方向的短波多站和单星协同直接定位方法
US12535420B2 (en) 2020-02-18 2026-01-27 Pacific Biosciences Of California, Inc. Highly multiplexed nucleic acid sequencing systems
TW202147591A (zh) 2020-03-02 2021-12-16 美商寬騰矽公司 用於多維信號分析之整合感應器
KR20220165754A (ko) 2020-04-08 2022-12-15 퀀텀-에스아이 인코포레이티드 스큐가 감소된 통합 센서
CN111533083B (zh) * 2020-05-08 2023-09-05 中北大学 一种基于石墨烯的微型分子光镊
AU2021276522A1 (en) 2020-05-20 2023-01-05 Quantum-Si Incorporated Methods and compositions for protein sequencing
CA3182266A1 (en) 2020-06-11 2021-12-16 Vadim Lobanov Methods and systems for computational decoding of biological, chemical, and physical entities
EP4179001A4 (en) * 2020-07-07 2024-07-10 Twist Bioscience Corporation DEVICES AND METHODS FOR LIGHT ORIENTATION POLYMER SYNTHESIS
WO2022020731A2 (en) * 2020-07-23 2022-01-27 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
US12472492B2 (en) 2020-08-14 2025-11-18 Alveo Technologies, Inc. Systems and methods of sample depositing and testing
KR102628182B1 (ko) * 2020-08-28 2024-01-24 한국과학기술원 상호정보량 최소화를 통한 다색 분리 방법 및 장치
EP3961194B1 (en) 2020-08-25 2023-11-08 Korea Advanced Institute of Science and Technology Method and apparatus for multiplexed imaging of biomolecules through iterative unmixing of fluorophore signals
KR102423723B1 (ko) * 2020-08-27 2022-07-21 성균관대학교산학협력단 플라즈모닉 우물 기반 핵산 검출장치 및 롤투롤 공정을 이용한 이의 제조방법
GB2599729A (en) * 2020-10-12 2022-04-13 Sumitomo Chemical Co Method comprising light emitting marker
KR20230097103A (ko) * 2020-10-27 2023-06-30 퀀텀-에스아이 인코포레이티드 광표백 정보를 이용한 단일 분자 검출 시스템
TWI824273B (zh) * 2020-12-03 2023-12-01 仁寶電腦工業股份有限公司 天線裝置和配置該天線裝置的方法
AU2021401791A1 (en) 2020-12-15 2023-07-06 Quantum-Si Incorporated Molecular barcode analysis by single-molecule kinetics
US20220227890A1 (en) 2021-01-21 2022-07-21 Nautilus Biotechnology, Inc. Systems and methods for biomolecule preparation
CN112837620B (zh) * 2021-01-22 2023-07-04 武汉京东方光电科技有限公司 柔性显示屏及电子设备
CN112864258B (zh) * 2021-03-05 2025-01-10 南京扬字源科技有限公司 像素结构、红外图像传感器和电子设备
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
WO2022235794A1 (en) * 2021-05-04 2022-11-10 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices with reduced-scale unit cell
DE102021111787A1 (de) * 2021-05-06 2022-11-10 Gesellschaft für angewandte Mikro- und Optoelektronik mit beschränkter Haftung - AMO GmbH Verfahren zur Herstellung einer Lochblende, Lochblende sowie Verwendung einer Lochblende in einem optischen Aufbau
CN112986206B (zh) * 2021-05-20 2021-07-30 北京百奥纳芯生物科技有限公司 一种检测基因芯片杂交结果的方法
US11703445B2 (en) * 2021-05-28 2023-07-18 Visera Technologies Company Limited Biosensor with grating array
CN117730396A (zh) * 2021-08-04 2024-03-19 深圳华大智造科技股份有限公司 利用三维衬底的测序系统和方法
EP4399528A1 (en) 2021-09-09 2024-07-17 Nautilus Subsidiary, Inc. Characterization and localization of protein modifications
EP4405683A1 (en) 2021-09-22 2024-07-31 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
US20230114694A1 (en) * 2021-10-11 2023-04-13 Quantum-Si Incorporated Light coupling device
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US20230152211A1 (en) * 2021-11-11 2023-05-18 California Institute Of Technology System for Optically Analyzing a Test Sample and Method Therefor
WO2023114209A1 (en) * 2021-12-14 2023-06-22 Quantum-Si Incorporated Methods for loading and data acquisition
US12587764B2 (en) 2021-12-31 2026-03-24 Samsung Electronics Co., Ltd. Flexible computational image sensor with compressive sensing capability
WO2023137051A2 (en) 2022-01-12 2023-07-20 Quantum-Si Incorporated Integrated sensor
WO2023137314A1 (en) * 2022-01-12 2023-07-20 Quantum-Si Incorporated Labeled binding reagents and methods of use thereof
US11924963B2 (en) 2022-02-03 2024-03-05 Raytheon Company Printed-circuit isolation barrier for co-site interference mitigation
US20250172488A1 (en) * 2022-02-28 2025-05-29 Bio-Rad Laboratories, Inc. Wide-spectrum analysis system
CN120019439A (zh) * 2022-03-29 2025-05-16 帕特恩电脑公司 用于基于光谱的疾病检测的系统和方法
CA3245990A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. INTEGRATED NETWORKS FOR SINGLE-ANALYTE PROCESSES
KR102953379B1 (ko) * 2022-06-10 2026-04-17 한국전자통신연구원 Pcr 진단 장치
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
US12353011B2 (en) * 2022-06-27 2025-07-08 Taiwan Semiconductor Manufacturing Co., Ltd. Photonic package and method of manufacture
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
US12515223B2 (en) 2022-10-24 2026-01-06 Samsung Electronics Co., Ltd. 3D-tapered nanocavities with on-chip optical and molecular concentration for single molecule diagnostics
EP4379355A1 (en) * 2022-11-29 2024-06-05 Gnothis Holding AG High throughput analysis of single molecule events
US20240192202A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. Fluidic media for single-analtye arrays
CN120712049A (zh) 2022-12-15 2025-09-26 阿达普提克斯生物科学公司 用于分析物检测的系统和方法
EP4634285A1 (en) 2022-12-15 2025-10-22 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
US20240295297A1 (en) * 2023-02-28 2024-09-05 Japan Cell Co., Ltd. Synthesized light generation method, optical characteristic converting component, light source, optical noise reduction method, measurement method, imaging method, signal processing and/or data analysis method, data analysis program, display method, communication method, service providing method, optical device, and service providing system
WO2024187170A2 (en) * 2023-03-09 2024-09-12 University Of Cincinnati Optical aptamer biosensors for in-vivo sensing
EP4689173A1 (en) 2023-03-24 2026-02-11 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
EP4694861A1 (en) 2023-04-13 2026-02-18 Lucas Meyer Cosmetics Emulsifying agent based on lignin fraction and uses thereof
WO2024229244A2 (en) * 2023-05-03 2024-11-07 Mirvie, Inc. Methods and systems for determining a pregnancy-related state of a subject
US20240402685A1 (en) * 2023-05-22 2024-12-05 The Hong Kong Polytechnic University Certification Framework for STEM Industrial Products
US20240394902A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
US12373188B2 (en) 2023-07-06 2025-07-29 Bank Of America Corporation Systems, methods, and apparatuses for improving computer energy consumption and computer processing by implementing a pluggable carbon emission gateway
ES2958785B2 (es) * 2023-07-17 2024-07-24 Univ Valencia Politecnica Dispositivo de medida para el analisis de la respuesta optica de materiales biosensibles difractivos
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
WO2025047492A1 (ja) * 2023-08-30 2025-03-06 富士フイルム株式会社 測定装置
WO2025094175A1 (en) * 2023-10-29 2025-05-08 B.G. Negev Technologies And Applications Ltd. All optical single photon detector
US20250189519A1 (en) 2023-12-11 2025-06-12 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
US20250205706A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
US20250298016A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
US20250305034A1 (en) 2024-04-01 2025-10-02 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation
US12656256B2 (en) 2024-08-27 2026-06-16 Visera Technologies Company Ltd. Analytical biochip and forming method thereof

Family Cites Families (208)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006716A (en) 1989-02-22 1991-04-09 Research Corporation Technologies, Inc. Method and system for directional, enhanced fluorescence from molecular layers
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
JP3018687B2 (ja) * 1991-12-12 2000-03-13 松下電器産業株式会社 走査型レーザー顕微鏡
US5355215A (en) 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
CA2155186A1 (en) 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
JP3169742B2 (ja) * 1993-06-18 2001-05-28 松下電器産業株式会社 光分岐装置および光ディスク装置
JPH07182686A (ja) * 1993-12-21 1995-07-21 Matsushita Electric Ind Co Ltd 光モード変換装置および光分岐装置
US5495462A (en) * 1993-06-18 1996-02-27 Matsushita Electric Industrial Co., Ltd. Light beam splitting apparatus
US6570617B2 (en) 1994-01-28 2003-05-27 California Institute Of Technology CMOS active pixel sensor type imaging system on a chip
US5471515A (en) 1994-01-28 1995-11-28 California Institute Of Technology Active pixel sensor with intra-pixel charge transfer
MXPA96005828A (es) 1994-05-27 2005-07-15 Novartis Ag Tambien Denominada Proceso para detectar luminescencia excitada evanescentemente.
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
US5990506A (en) 1996-03-20 1999-11-23 California Institute Of Technology Active pixel sensors with substantially planarized color filtering elements
JP3748571B2 (ja) 1996-11-18 2006-02-22 ノバルティス アクチエンゲゼルシャフト 測定装置及びその使用方法
IL156002A0 (en) 1997-02-12 2003-12-23 Eugene Y Chan Methods and products for analyzing polymers
JP3435416B2 (ja) 1997-03-12 2003-08-11 ピーイー コーポレイション（エヌワイ） 改善された標識ヌクレオチド取込み特性を有するｄｎａポリメラーゼ
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6825921B1 (en) * 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
EP0921196A1 (en) 1997-12-02 1999-06-09 Roche Diagnostics GmbH Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
JPH11173987A (ja) 1997-12-12 1999-07-02 Hamamatsu Photonics Kk マイクロタイタビューア
DE19810879A1 (de) 1998-03-13 1999-09-16 Roche Diagnostics Gmbh Polymerasenchimären
US6232103B1 (en) 1998-03-23 2001-05-15 Invitrogen Corporation Methods useful for nucleic acid sequencing using modified nucleotides comprising phenylboronic acid
JP3813818B2 (ja) 1998-05-01 2006-08-23 アリゾナ ボード オブ リージェンツ オリゴヌクレオチドおよびｄｎａ分子のヌクレオチド配列の決定方法
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
GB9810350D0 (en) 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
JP2000004871A (ja) 1998-06-29 2000-01-11 Olympus Optical Co Ltd 培養容器、及び培養容器内の試料を観察する顕微鏡
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6280939B1 (en) 1998-09-01 2001-08-28 Veeco Instruments, Inc. Method and apparatus for DNA sequencing using a local sensitive force detector
WO2000036152A1 (en) 1998-12-14 2000-06-22 Li-Cor, Inc. A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
US6134002A (en) * 1999-01-14 2000-10-17 Duke University Apparatus and method for the rapid spectral resolution of confocal images
AU3174600A (en) 1999-03-10 2000-09-28 Asm Scientific, Inc. A method for direct nucleic acid sequencing
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
EP1681356B1 (en) 1999-05-19 2011-10-19 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6137117A (en) 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
FR2797053B1 (fr) * 1999-07-13 2001-08-31 Commissariat Energie Atomique Support d'analyse a transmission de lumiere de fluorescence
US6596483B1 (en) * 1999-11-12 2003-07-22 Motorola, Inc. System and method for detecting molecules using an active pixel sensor
US6399335B1 (en) 1999-11-16 2002-06-04 Advanced Research And Technology Institute, Inc. γ-phosphoester nucleoside triphosphates
DE50006533D1 (de) * 1999-12-17 2004-06-24 Zeptosens Ag Witterswil Anordnung von probenbehältnissen und deren verwendung zur multianalytbestimmung
JP3978307B2 (ja) * 2000-02-09 2007-09-19 株式会社日立製作所 紫外レーザ光発生装置並びに欠陥検査装置およびその方法
WO2001069211A1 (en) * 2000-03-16 2001-09-20 Spectrumedix Corporation Multi-wavelength array reader for biological assay
WO2001084197A1 (en) * 2000-04-28 2001-11-08 Edgelight Biosciences, Inc. Micro-array evanescent wave fluorescence detection device
US6917726B2 (en) * 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
EP1287154A4 (en) 2000-06-07 2010-12-15 Pacific Biosciences California NUCLEOTIDES WITH CHARGE SWITCHING
WO2002001194A1 (en) 2000-06-25 2002-01-03 Affymetrix, Inc. Optically active substrates
US7277166B2 (en) 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
FR2813121A1 (fr) 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
AU2001286963A1 (en) 2000-08-30 2002-03-13 University Of Rochester Method of performing reverse transcription reaction using reverse transcriptase encoded by non-ltr retrotransposable element
AU2001284681A1 (en) 2000-09-11 2002-03-26 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluidics system
WO2002034944A1 (en) 2000-10-23 2002-05-02 Dia Chip Limited High precision and intellectual biochip arrayer having function of respotting
JP3695340B2 (ja) * 2001-03-30 2005-09-14 株式会社日立製作所 Ｄｎａ検査方法及びその装置並びに蛍光検出方法
US20040259082A1 (en) 2001-04-24 2004-12-23 Li-Cor, Inc. Polymerases with charge-switch activity and methods of generating such polymers
US7244566B2 (en) 2001-08-29 2007-07-17 Ge Healthcare Bio-Sciences Corp. Analyte detection
US7052839B2 (en) 2001-08-29 2006-05-30 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides and methods of use
US7223541B2 (en) 2001-08-29 2007-05-29 Ge Healthcare Bio-Sciences Corp. Terminal-phosphate-labeled nucleotides and methods of use
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
US7727722B2 (en) 2001-08-29 2010-06-01 General Electric Company Ligation amplification
US7256019B2 (en) 2001-08-29 2007-08-14 Ge Healthcare Bio-Sciences Corp. Terminal phosphate blocked nucleoside polyphosphates
WO2003020734A2 (en) 2001-08-29 2003-03-13 Amersham Biosciences Corp Labeled nucleoside polyphosphates
ATE528117T1 (de) * 2001-08-30 2011-10-15 Bayer Technology Services Gmbh Verfahren zur herstellung von abformkörpern, insbesondere optischen strukturen, und deren verwendung
WO2003025132A2 (en) 2001-09-14 2003-03-27 Invitrogen Corporation Dna polymerases and mutants thereof
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US7179654B2 (en) 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
US6924887B2 (en) 2002-03-27 2005-08-02 Sarnoff Corporation Method and apparatus for generating charge from a light pulse
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
WO2004072238A2 (en) 2003-02-05 2004-08-26 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides with new linkers
US7745116B2 (en) 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
US20040258563A1 (en) * 2003-06-23 2004-12-23 Applera Corporation Caps for sample wells and microcards for biological materials
CN1209619C (zh) 2003-07-18 2005-07-06 华中科技大学 塑料生物芯片的键合和封装装置
WO2005016526A2 (en) * 2003-08-04 2005-02-24 Irm, Llc Multi-well container positioning devices and related systems and methods
WO2005073407A1 (en) * 2003-10-07 2005-08-11 Ut-Battelle, Llc Advanced integrated circuit biochip
US20050079102A1 (en) 2003-10-14 2005-04-14 Staton Kenneth L. Interrogation apparatus
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US20070281288A1 (en) 2004-01-27 2007-12-06 Shimshon Belkin Method and System for Detecting Analytes
ATE463584T1 (de) 2004-02-19 2010-04-15 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
WO2006036388A2 (en) * 2004-08-23 2006-04-06 U.S. Genomics, Inc. Systems and methods for detecting and analyzing polymers
US7315019B2 (en) 2004-09-17 2008-01-01 Pacific Biosciences Of California, Inc. Arrays of optical confinements and uses thereof
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US8293430B2 (en) * 2005-01-27 2012-10-23 Applied Materials, Inc. Method for etching a molybdenum layer suitable for photomask fabrication
US7345764B2 (en) 2005-02-07 2008-03-18 Vladimir Bulovic Apparatus and method for a slim format spectrometer
US20060223067A1 (en) 2005-03-31 2006-10-05 Paolo Vatta Mutant DNA polymerases and methods of use
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
CN100401041C (zh) * 2005-06-09 2008-07-09 上海交通大学 光波导吸收式气体传感器及测量系统
WO2007002890A2 (en) 2005-06-28 2007-01-04 Agencourt Personal Genomics Corporation Methods of producing and sequencing modified polynucleotides
EP1920072A2 (en) 2005-07-01 2008-05-14 Dako Denmark A/S In situ hybridization detection method
US7426322B2 (en) 2005-07-20 2008-09-16 Searete Llc. Plasmon photocatalysis
US20160355869A1 (en) * 2005-08-02 2016-12-08 University Of Utah Research Foundation Biosensors including metallic nanocavities
JP2009503548A (ja) * 2005-08-02 2009-01-29 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 金属ナノキャビティを含むバイオセンサー
US7453916B2 (en) * 2005-09-08 2008-11-18 Intel Corporation High throughput optical micro-array reader capable of variable pitch and spot size array processing for genomics and proteomics
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
TWI296044B (en) * 2005-11-03 2008-04-21 Ind Tech Res Inst Coupled waveguide-surface plasmon resonance biosensor
JP2009519041A (ja) 2005-12-12 2009-05-14 アメリカ合衆国 核酸配列決定のためのプローブおよび使用方法
JP2009521227A (ja) 2005-12-22 2009-06-04 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド ヌクレオチドアナログ組込み用ポリメラーゼ
AU2006331512B2 (en) 2005-12-22 2012-02-23 Pacific Biosciences Of California, Inc. Active surface coupled polymerases
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7692783B2 (en) 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US20080050747A1 (en) 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US7750316B2 (en) * 2006-05-10 2010-07-06 Dublin City University Polymer biochip for detecting fluorescence
WO2007133710A2 (en) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Microfluidic devices and methods of use thereof
DE102006030541B4 (de) 2006-06-23 2010-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optische Anordnung
AU2007289057C1 (en) 2006-09-01 2014-01-16 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8471230B2 (en) 2006-09-01 2013-06-25 Pacific Biosciences Of California, Inc. Waveguide substrates and optical systems and methods of use thereof
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
EP2089517A4 (en) 2006-10-23 2010-10-20 Pacific Biosciences California POLYMERASEENZYME AND REAGENTS FOR ADVANCED NUCKIC ACID SEQUENCING
US9218944B2 (en) * 2006-10-30 2015-12-22 Applied Materials, Inc. Mask etch plasma reactor having an array of optical sensors viewing the workpiece backside and a tunable element controlled in response to the optical sensors
FR2908888B1 (fr) 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
JP2010524012A (ja) 2007-03-22 2010-07-15 ユニベルシテ・ドウ・ストラスブール 電磁エネルギーを選別して集めるデバイス、及び、そのようなデバイスを少なくとも１つ備える装置
US20080241866A1 (en) 2007-03-30 2008-10-02 Pacific Biosciences Of California, Inc. Systems and methods for enhancing fluorescent signals
JP5222599B2 (ja) * 2007-07-20 2013-06-26 株式会社日立ハイテクノロジーズ 核酸分析デバイス及びそれを用いた核酸分析装置
JP2009022247A (ja) * 2007-07-23 2009-02-05 Toshiba Corp 培養容器及び培養組織回収方法
US9410892B2 (en) * 2007-08-30 2016-08-09 Cornell University Nanoscale optofluidic devices for molecular detection
WO2009038791A1 (en) * 2007-09-18 2009-03-26 Applied Biosystems Inc. Methods, systems and apparatus for light concentrating mechanisms
US7873085B2 (en) 2007-10-23 2011-01-18 Andrei Babushkin Method and device for controlling optical output of laser diode
GB0723725D0 (en) 2007-12-05 2008-01-16 Ge Healthcare Uk Ltd Apparatus and method for detecting dna damage
WO2009082706A1 (en) 2007-12-21 2009-07-02 The Trustees Of Columbia University In The City Of New York Active cmos sensor array for electrochemical biomolecular detection
WO2009091847A2 (en) 2008-01-14 2009-07-23 Life Technologies Corporation Compositions, methods and systems for single molecule sequencing
EP2252625B1 (en) 2008-02-07 2017-12-20 Pacific Biosciences of California, Inc. Cis reactive oxygen quenchers integrated into linkers
US8530164B2 (en) 2008-09-05 2013-09-10 Pacific Biosciences Of California, Inc. Method for sequencing using branching fraction of incorporatable nucleotides
US8652781B2 (en) 2008-02-12 2014-02-18 Pacific Biosciences Of California, Inc. Cognate sampling kinetics
CA2715385A1 (en) 2008-02-12 2009-08-20 Pacific Biosciences Of California, Inc. Compositions and methods for use in analytical reactions
US7968702B2 (en) 2008-03-13 2011-06-28 Pacific Biosciences Of California, Inc. Labeled reactants and their uses
US20090243584A1 (en) * 2008-03-25 2009-10-01 Guigen Zhang Fabrication of microstructures integrated with nanopillars along with their applications as electrodes in sensors
US7973146B2 (en) 2008-03-26 2011-07-05 Pacific Biosciences Of California, Inc. Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
WO2009120374A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
JP2011515102A (ja) 2008-03-28 2011-05-19 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド 核酸シーケンシング用組成物及び方法
US8143030B2 (en) 2008-09-24 2012-03-27 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
EP2271751B1 (en) 2008-03-31 2015-07-22 Pacific Biosciences of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8420366B2 (en) 2008-03-31 2013-04-16 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8906831B2 (en) 2008-03-31 2014-12-09 Pacific Biosciences Of California, Inc. Single molecule loading methods and compositions
US9127259B2 (en) 2008-03-31 2015-09-08 Pacific Biosciences Of California, Inc. Enzymes resistant to photodamage
US8133672B2 (en) 2008-03-31 2012-03-13 Pacific Biosciences Of California, Inc. Two slow-step polymerase enzyme systems and methods
US8999676B2 (en) 2008-03-31 2015-04-07 Pacific Biosciences Of California, Inc. Recombinant polymerases for improved single molecule sequencing
US10114213B2 (en) 2008-04-04 2018-10-30 Cvi Laser, Llc Laser systems and optical devices for manipulating laser beams
JP5268444B2 (ja) * 2008-06-23 2013-08-21 株式会社日立ハイテクノロジーズ 単分子リアルタイムシーケンス装置，核酸分析装置及び単分子リアルタイムシーケンス方法
EP2148187A1 (de) * 2008-07-25 2010-01-27 Roche Diagnostics GmbH Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion
US7999454B2 (en) * 2008-08-14 2011-08-16 Global Oled Technology Llc OLED device with embedded chip driving
FR2936099A1 (fr) * 2008-09-12 2010-03-19 Thales Sa Dispositif de detection d'images ameliore pour un imageur multispectral et imageur multispectral comportant ce dispositif
US8481264B2 (en) 2008-09-19 2013-07-09 Pacific Biosciences Of California, Inc. Immobilized nucleic acid complexes for sequence analysis
US8921046B2 (en) 2008-09-19 2014-12-30 Pacific Biosciences Of California, Inc. Nucleic acid sequence analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8383369B2 (en) 2008-09-24 2013-02-26 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US8247216B2 (en) 2008-09-30 2012-08-21 Pacific Biosciences Of California, Inc. Ultra-high multiplex analytical systems and methods
KR101045206B1 (ko) * 2008-10-31 2011-06-30 삼성전자주식회사 여기광 흡수 도파로가 삽입된 집적된 바이오칩 및 그 제조방법
EP2182523B1 (en) 2008-10-31 2013-01-09 CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement Charge sampling device and method based on a MOS-transmission line
KR101065077B1 (ko) * 2008-11-05 2011-09-15 삼성전자주식회사 시료 검출용 기판, 이를 채용한 바이오칩, 시료 검출용 기판의 제조방법 및 바이오 물질 검출장치
WO2010057185A1 (en) 2008-11-17 2010-05-20 Pacific Biosciences Of California, Inc. Phospholink nucleotides for sequencing applications
CN102482330A (zh) 2009-01-30 2012-05-30 牛津纳米孔技术有限公司 酶突变体
EP2221606A3 (en) * 2009-02-11 2012-06-06 Samsung Electronics Co., Ltd. Integrated bio-chip and method of fabricating the integrated bio-chip
WO2010111674A2 (en) 2009-03-27 2010-09-30 Life Technologies Corporation Methods and apparatus for single molecule sequencing using energy transfer detection
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
JP5707030B2 (ja) * 2009-04-02 2015-04-22 株式会社日立ハイテクノロジーズ 核酸分析デバイス、及び核酸分析装置
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
JP5462548B2 (ja) * 2009-08-12 2014-04-02 株式会社日立ハイテクノロジーズ 核酸分析素子及びそれを用いた核酸分析装置
WO2011040971A2 (en) 2009-09-30 2011-04-07 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8278728B2 (en) 2009-10-17 2012-10-02 Florida Institute Of Technology Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels
WO2011068569A1 (en) 2009-12-04 2011-06-09 Biotium, Inc. Heterocycle-substituted xanthene dyes
JP6017107B2 (ja) 2009-12-28 2016-10-26 ソニー株式会社 イメージセンサ及びその製造方法、並びにセンサデバイス
US20110236983A1 (en) 2009-12-29 2011-09-29 Joseph Beechem Single molecule detection and sequencing using fluorescence lifetime imaging
EP2933629B1 (en) 2010-02-19 2019-04-10 Pacific Biosciences Of California, Inc. System for measuring analytical reactions comprising a socket for an optode array chip
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US9482615B2 (en) * 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
TWI466278B (zh) 2010-04-06 2014-12-21 勝開科技股份有限公司 晶圓級影像感測器構裝結構及其製造方法
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865078B2 (en) * 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
EP2439512A1 (en) * 2010-10-01 2012-04-11 Aqsens Oy A device for holding a sample
EP2441520A1 (en) 2010-10-12 2012-04-18 Eppendorf AG Real-time amplification and micro-array based detection of nucleic acid targets in a flow chip assay
CN103380500B (zh) 2010-11-30 2015-12-09 茨瓦内科技大学 基于cmos的微光子系统
JP2013545475A (ja) 2010-11-30 2013-12-26 クワンタムディーエックス・グループ・リミテッド マイクロ流体多重温度可撓性反応デバイスの設計、製造及び使用
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
JP2013045857A (ja) 2011-08-24 2013-03-04 Sony Corp イメージセンサ及びその製造方法並びに検査装置
FR2982028B1 (fr) 2011-10-26 2020-02-21 Aryballe Technologies Puce microstructuree comprenant des surfaces convexes pour analyse par resonance des plasmons de surface, dispositif d'analyse contenant ladite puce microstructuree et utilisation dudit dispositif
CA2856163C (en) 2011-10-28 2019-05-07 Illumina, Inc. Microarray fabrication system and method
US9606060B2 (en) 2012-01-13 2017-03-28 California Institute Of Technology Filterless time-domain detection of one or more fluorophores
US8906660B2 (en) 2012-02-01 2014-12-09 Pacific Biosciences Of California, Inc. Recombinant polymerases with increased phototolerance
EP3222627B1 (en) 2012-02-15 2019-08-07 Pacific Biosciences of California, Inc. Polymerase enzyme substrates with protein shield
US9059250B2 (en) * 2012-02-17 2015-06-16 International Business Machines Corporation Lateral-dimension-reducing metallic hard mask etch
EP2831283A4 (en) * 2012-03-30 2015-11-04 Pacific Biosciences California METHODS AND COMPOSITION FOR SEQUENCING MODIFIED NUCLEIC ACIDS
AU2013246359B2 (en) * 2012-04-10 2017-03-30 The Trustees Of Princeton University Ultra-sensitive sensor
WO2013171197A1 (en) 2012-05-15 2013-11-21 Ait Austrian Institute Of Technology Gmbh Compact plasmon-enhanced fluorescence biosensor
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
US8654427B1 (en) 2012-08-31 2014-02-18 Rosemount Aerospace Inc. Ruggedized two-axis optical beam steering device
EP2936222B1 (en) 2012-12-18 2019-07-03 Pacific Biosciences Of California, Inc. An optical analytical device
WO2014130900A1 (en) * 2013-02-22 2014-08-28 Pacific Biosciences Of California, Inc. Integrated illumination of optical analytical devices
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
WO2014144548A2 (en) 2013-03-15 2014-09-18 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US9654680B2 (en) * 2013-10-17 2017-05-16 Canon Kabushiki Kaisha Image capturing apparatus and control method therefor
EP3709003A1 (en) 2013-11-17 2020-09-16 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecules
WO2015141873A1 (ko) 2014-03-18 2015-09-24 서울대학교산학협력단 광영역 시료를 고속 정량 분석하는 라만 분석 방법 및 장치
US9765395B2 (en) 2014-04-28 2017-09-19 Nanomedical Diagnostics, Inc. System and method for DNA sequencing and blood chemistry analysis
CN111710687B (zh) 2014-08-08 2023-11-14 宽腾矽公司 基于入射光子到达时间的识别、成像、测序法及存储介质
US9885657B2 (en) 2014-08-08 2018-02-06 Quantum-Si Incorporated Integrated device with external light source for probing detecting and analyzing molecules
KR102738114B1 (ko) * 2014-08-08 2024-12-06 퀀텀-에스아이 인코포레이티드 분자들을 프로빙, 검출 및 분석하기 위한 광학계 및 검정 칩
US9666748B2 (en) 2015-01-14 2017-05-30 International Business Machines Corporation Integrated on chip detector and zero waveguide module structure for use in DNA sequencing
CN113064236B (zh) 2015-03-16 2022-11-01 加利福尼亚太平洋生物科学股份有限公司 用于自由空间光耦合的集成装置及系统
US10246742B2 (en) 2015-05-20 2019-04-02 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10605730B2 (en) 2015-05-20 2020-03-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
CN105039147B (zh) 2015-06-03 2016-05-04 西安交通大学 一种高通量基因测序碱基荧光图像捕获系统装置及方法
CA3069983A1 (en) 2017-07-24 2019-01-31 Quantum-Si Incorporated Hand-held, massively-parallel, bio-optoelectronic instrument

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
John Eid et al, "Real-time DNA sequencing from single polymerase molecules", Science *
Methods in Enzymology, (2010), Vol.472, pages 431 - 455 *

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