CN103030617A - 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 - Google Patents

吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 Download PDF

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Publication number
CN103030617A
CN103030617A CN2012105151009A CN201210515100A CN103030617A CN 103030617 A CN103030617 A CN 103030617A CN 2012105151009 A CN2012105151009 A CN 2012105151009A CN 201210515100 A CN201210515100 A CN 201210515100A CN 103030617 A CN103030617 A CN 103030617A
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alkyl
aryl
benzyl
groups
substituted
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Inventor
弗兰克.希梅尔斯巴赫
马赛厄斯.埃克哈特
彼得.艾克尔曼
爱德华.L.巴索米恩
利奥.托马斯
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Priority claimed from DE102004012676A external-priority patent/DE102004012676A1/de
Priority claimed from DE102004040168A external-priority patent/DE102004040168A1/de
Priority claimed from DE102004061145A external-priority patent/DE102004061145A1/de
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CN103030617A publication Critical patent/CN103030617A/zh
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CN2012105151009A 2004-03-16 2005-03-11 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 Pending CN103030617A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE102004012676A DE102004012676A1 (de) 2004-03-16 2004-03-16 Glucopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE102004012676.3 2004-03-16
DE102004040168.3 2004-08-18
DE102004040168A DE102004040168A1 (de) 2004-08-18 2004-08-18 Glucopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE102004061145.9 2004-12-16
DE102004061145A DE102004061145A1 (de) 2004-12-16 2004-12-16 Glucopyranosyl-substituierte Benzol-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
EP05002628.5 2005-02-09
EP05002628 2005-02-09

Related Parent Applications (1)

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CNA2005800069449A Division CN1930141A (zh) 2004-03-16 2005-03-11 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法

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CN103030617A true CN103030617A (zh) 2013-04-10

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CN2012105151009A Pending CN103030617A (zh) 2004-03-16 2005-03-11 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
CN201310414119.9A Ceased CN103450129B (zh) 2004-03-16 2005-03-11 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
CN201310368328.4A Ceased CN103467423B (zh) 2004-03-16 2005-03-11 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
CN201310379906.4A Ceased CN103435581B (zh) 2004-03-16 2005-03-11 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法

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CN201310414119.9A Ceased CN103450129B (zh) 2004-03-16 2005-03-11 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
CN201310368328.4A Ceased CN103467423B (zh) 2004-03-16 2005-03-11 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
CN201310379906.4A Ceased CN103435581B (zh) 2004-03-16 2005-03-11 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法

Country Status (33)

Country Link
US (6) US7579449B2 (https=)
EP (4) EP2360165A3 (https=)
JP (3) JP4181605B2 (https=)
KR (2) KR20120007088A (https=)
CN (4) CN103030617A (https=)
AR (3) AR048041A1 (https=)
AT (1) ATE557013T1 (https=)
AU (1) AU2005225511C1 (https=)
BE (1) BE2014C064I2 (https=)
BR (1) BRPI0508830B8 (https=)
CA (1) CA2557801C (https=)
CY (2) CY1112948T1 (https=)
DK (1) DK1730131T3 (https=)
EA (1) EA011158B1 (https=)
EC (1) ECSP066855A (https=)
ES (1) ES2387881T3 (https=)
FR (1) FR14C0074I2 (https=)
HR (1) HRP20120627T1 (https=)
HU (1) HUS1400056I1 (https=)
IL (2) IL218714A (https=)
LT (1) LTC1730131I2 (https=)
LU (1) LU92555I2 (https=)
ME (1) ME01422B (https=)
MY (1) MY151336A (https=)
NO (3) NO335264B1 (https=)
NZ (1) NZ550464A (https=)
PL (1) PL1730131T3 (https=)
PT (1) PT1730131E (https=)
RS (1) RS52365B (https=)
SG (1) SG151271A1 (https=)
SI (1) SI1730131T1 (https=)
TW (1) TWI323264B (https=)
WO (1) WO2005092877A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104761522A (zh) * 2014-01-03 2015-07-08 山东轩竹医药科技有限公司 光学纯的苄基-4-氯苯基的c-糖苷衍生物
CN104861002A (zh) * 2014-02-26 2015-08-26 天津药物研究院 含3,6-脱水葡萄糖结构的苯基c-葡萄糖苷衍生物及其制备方法和用途
CN106336403A (zh) * 2015-07-14 2017-01-18 江苏豪森药业集团有限公司 依帕列净的工业制备方法
CN108285439A (zh) * 2017-01-09 2018-07-17 江苏天士力帝益药业有限公司 一种碳糖苷类钠葡萄糖转运蛋白体2抑制剂
CN112047915A (zh) * 2019-06-05 2020-12-08 吉林惠升生物制药有限公司 C-糖苷类衍生物新的制备工艺

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US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
CN103030617A (zh) * 2004-03-16 2013-04-10 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
US7393836B2 (en) * 2004-07-06 2008-07-01 Boehringer Ingelheim International Gmbh D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
WO2006010557A1 (de) * 2004-07-27 2006-02-02 Boehringer Ingelheim International Gmbh D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
DE102004048388A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE602005009745D1 (de) * 2004-12-16 2008-10-23 Boehringer Ingelheim Pharma Glucopyranosyl-substituierte benzen-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür
TW200637869A (en) 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
JP5264183B2 (ja) 2005-02-23 2013-08-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシル置換（（ヘテロ）アリールエチニル−ベンジル）−ベンゼン誘導体及びナトリウム依存性グルコース共輸送体２（ｓｇｌｔ２）インヒビターとしてのそれらの使用
ATE453656T1 (de) 2005-04-15 2010-01-15 Boehringer Ingelheim Int Glucopyranosyl-substituierte (heteroaryloxy- benzyl)-benzen-derivate als sglt-inhibitoren
UA91546C2 (uk) * 2005-05-03 2010-08-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ
US7723309B2 (en) 2005-05-03 2010-05-25 Boehringer Ingelheim International Gmbh Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
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CN104761522B (zh) * 2014-01-03 2017-02-15 山东轩竹医药科技有限公司 光学纯的苄基‑4‑氯苯基的c‑糖苷衍生物
CN106349201B (zh) * 2014-01-03 2018-09-18 山东轩竹医药科技有限公司 光学纯的苄基-4-氯苯基的c-糖苷衍生物
CN104861002A (zh) * 2014-02-26 2015-08-26 天津药物研究院 含3,6-脱水葡萄糖结构的苯基c-葡萄糖苷衍生物及其制备方法和用途
CN106336403A (zh) * 2015-07-14 2017-01-18 江苏豪森药业集团有限公司 依帕列净的工业制备方法
CN108285439A (zh) * 2017-01-09 2018-07-17 江苏天士力帝益药业有限公司 一种碳糖苷类钠葡萄糖转运蛋白体2抑制剂
CN108285439B (zh) * 2017-01-09 2023-05-02 江苏天士力帝益药业有限公司 一种碳糖苷类钠葡萄糖转运蛋白体2抑制剂
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