CN102405286A - 减小大小的自递送RNAi化合物 - Google Patents

减小大小的自递送RNAi化合物 Download PDF

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CN102405286A
CN102405286A CN2009801464922A CN200980146492A CN102405286A CN 102405286 A CN102405286 A CN 102405286A CN 2009801464922 A CN2009801464922 A CN 2009801464922A CN 200980146492 A CN200980146492 A CN 200980146492A CN 102405286 A CN102405286 A CN 102405286A
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nucleotides
strand
nucleic acid
guide strand
stranded
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阿纳斯塔西娅·赫沃罗娃
威廉·萨洛蒙
乔安妮·卡门斯
德米特里·萨马尔斯基
托德·M·伍尔夫
詹姆斯·卡迪亚
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Phio Pharmaceuticals Corp
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RXi Pharmaceuticals Corp
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Priority to CN201711334248.1A priority Critical patent/CN108165548B/zh
Publication of CN102405286A publication Critical patent/CN102405286A/zh
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CN2009801464922A 2008-09-22 2009-09-22 减小大小的自递送RNAi化合物 Pending CN102405286A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711334248.1A CN108165548B (zh) 2008-09-22 2009-09-22 减小大小的自递送RNAi化合物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US19295408P 2008-09-22 2008-09-22
US61/192,954 2008-09-22
US14994609P 2009-02-04 2009-02-04
US61/149,946 2009-02-04
US22403109P 2009-07-08 2009-07-08
US61/224,031 2009-07-08
PCT/US2009/005247 WO2010033247A2 (en) 2008-09-22 2009-09-22 Reduced size self-delivering rnai compounds

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CN201711334248.1A Division CN108165548B (zh) 2008-09-22 2009-09-22 减小大小的自递送RNAi化合物

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CN102405286A true CN102405286A (zh) 2012-04-04

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CN2009801464922A Pending CN102405286A (zh) 2008-09-22 2009-09-22 减小大小的自递送RNAi化合物
CN201711334248.1A Expired - Fee Related CN108165548B (zh) 2008-09-22 2009-09-22 减小大小的自递送RNAi化合物

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US (12) US8796443B2 (https=)
EP (5) EP2340309A2 (https=)
JP (5) JP2012502991A (https=)
CN (2) CN102405286A (https=)
AU (1) AU2009293658A1 (https=)
CA (4) CA2746527A1 (https=)
IL (1) IL211863A0 (https=)
WO (3) WO2010033247A2 (https=)

Cited By (8)

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CN104755620A (zh) * 2012-05-22 2015-07-01 奥利克斯医药有限公司 具有细胞内穿透能力的诱导rna干扰的核酸分子及其用途
CN106244590A (zh) * 2016-08-18 2016-12-21 广州市锐博生物科技有限公司 经修饰的siRNA分子、RNAi分子混合物及其应用
CN106498072A (zh) * 2016-11-24 2017-03-15 青岛千卓分子生物科技有限公司 一种液态产品中外源dna内标物的保护方法及其应用
CN108135923A (zh) * 2015-07-06 2018-06-08 阿克赛医药公司 靶向超氧化物歧化酶1（sod1）的核酸分子
CN112263587A (zh) * 2020-10-23 2021-01-26 河北仁博科技有限公司 miR-3065-5p在制备预防和/或治疗肾纤维化的药物中的应用
CN113151180A (zh) * 2013-12-02 2021-07-23 菲奥医药公司 癌症的免疫治疗
CN118526468A (zh) * 2023-03-29 2024-08-23 北京超环生物科技有限公司 一种负载核酸的脂质体纳米颗粒
CN121046387A (zh) * 2025-11-03 2025-12-02 谷雨生物科技集团股份有限公司 一种具有抗皮肤细胞衰老和修护功效的siRNA及其应用

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KR100949791B1 (ko) * 2007-12-18 2010-03-30 이동기 오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도
EP2252690A2 (en) * 2007-12-21 2010-11-24 Coda Therapeutics, Inc. Use of anti-connexin 43 polynucleotides for the treatment of abnormal or excessive scars
US10131904B2 (en) * 2008-02-11 2018-11-20 Rxi Pharmaceuticals Corporation Modified RNAi polynucleotides and uses thereof
US8815818B2 (en) 2008-07-18 2014-08-26 Rxi Pharmaceuticals Corporation Phagocytic cell delivery of RNAI
NZ601660A (en) 2008-08-25 2014-05-30 Excaliard Pharmaceuticals Inc Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
US8946172B2 (en) 2008-08-25 2015-02-03 Excaliard Pharmaceuticals, Inc. Method for reducing scarring during wound healing using antisense compounds directed to CTGF
CA2746527A1 (en) * 2008-09-22 2010-03-25 Rxi Pharmaceuticals Corporation Rna interference in skin indications
WO2010059226A2 (en) 2008-11-19 2010-05-27 Rxi Pharmaceuticals Corporation Inhibition of map4k4 through rnai
RU2620970C2 (ru) * 2008-12-04 2017-05-30 КьюРНА,Инк., Лечение связанных с эритропоэтином (еро) заболеваний путем ингибирования природного антисмыслового транскрипта к еро
US9493774B2 (en) 2009-01-05 2016-11-15 Rxi Pharmaceuticals Corporation Inhibition of PCSK9 through RNAi
US9745574B2 (en) 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
WO2011109248A1 (en) 2010-03-02 2011-09-09 Hapten Pharmaceuticals, Llc Effective sensitizing dose of a gelled immunomodulating topical composition
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