CA3020926C - Photoactive macromolecules and uses thereof - Google Patents

Photoactive macromolecules and uses thereof Download PDF

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Publication number
CA3020926C
CA3020926C CA3020926A CA3020926A CA3020926C CA 3020926 C CA3020926 C CA 3020926C CA 3020926 A CA3020926 A CA 3020926A CA 3020926 A CA3020926 A CA 3020926A CA 3020926 C CA3020926 C CA 3020926C
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polymer
independently
salt
hetero
aryl
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French (fr)
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CA3020926A1 (en
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Arunkumar Easwaran
Sergei Gulnik
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Beckman Coulter Inc
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Beckman Coulter Inc
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C08G61/122—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides
    • C08G61/123—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides derived from five-membered heterocyclic compounds
    • C08G61/126—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides derived from five-membered heterocyclic compounds with a five-membered ring containing one sulfur atom in the ring
    • C—CHEMISTRY; METALLURGY
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    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/02—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes
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    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C—CHEMISTRY; METALLURGY
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    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C08G61/122—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides
    • C08G61/123—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides derived from five-membered heterocyclic compounds
    • C08G61/124—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides derived from five-membered heterocyclic compounds with a five-membered ring containing one nitrogen atom in the ring
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/11—Homopolymers
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/12—Copolymers
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/12—Copolymers
    • C08G2261/124—Copolymers alternating
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/14—Side-groups
    • C08G2261/142—Side-chains containing oxygen
    • C08G2261/1424—Side-chains containing oxygen containing ether groups, including alkoxy
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/14—Side-groups
    • C08G2261/143—Side-chains containing nitrogen
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/14—Side-groups
    • C08G2261/145—Side-chains containing sulfur
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/14—Side-groups
    • C08G2261/145—Side-chains containing sulfur
    • C08G2261/1452—Side-chains containing sulfur containing sulfonyl or sulfonate-groups
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/16—End groups
    • C08G2261/164—End groups comprising organic end groups
    • C08G2261/1644—End groups comprising organic end groups comprising other functional groups, e.g. OH groups, NH groups, COOH groups or boronic acid
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/16—End groups
    • C08G2261/164—End groups comprising organic end groups
    • C08G2261/1646—End groups comprising organic end groups comprising aromatic or heteroaromatic end groups
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/30—Monomer units or repeat units incorporating structural elements in the main chain
    • C08G2261/31—Monomer units or repeat units incorporating structural elements in the main chain incorporating aromatic structural elements in the main chain
    • C08G2261/314—Condensed aromatic systems, e.g. perylene, anthracene or pyrene
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/30—Monomer units or repeat units incorporating structural elements in the main chain
    • C08G2261/31—Monomer units or repeat units incorporating structural elements in the main chain incorporating aromatic structural elements in the main chain
    • C08G2261/314—Condensed aromatic systems, e.g. perylene, anthracene or pyrene
    • C08G2261/3142—Condensed aromatic systems, e.g. perylene, anthracene or pyrene fluorene-based, e.g. fluorene, indenofluorene, or spirobifluorene
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/30—Monomer units or repeat units incorporating structural elements in the main chain
    • C08G2261/33—Monomer units or repeat units incorporating structural elements in the main chain incorporating non-aromatic structural elements in the main chain
    • C08G2261/332—Monomer units or repeat units incorporating structural elements in the main chain incorporating non-aromatic structural elements in the main chain containing only carbon atoms
    • C08G2261/3327—Monomer units or repeat units incorporating structural elements in the main chain incorporating non-aromatic structural elements in the main chain containing only carbon atoms alkene-based
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    • C08G2261/30—Monomer units or repeat units incorporating structural elements in the main chain
    • C08G2261/34—Monomer units or repeat units incorporating structural elements in the main chain incorporating partially-aromatic structural elements in the main chain
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/40—Polymerisation processes
    • C08G2261/41—Organometallic coupling reactions
    • C08G2261/411—Suzuki reactions
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/50—Physical properties
    • C08G2261/52—Luminescence
    • C08G2261/522—Luminescence fluorescent
    • C—CHEMISTRY; METALLURGY
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    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/90—Applications
    • C08G2261/94—Applications in sensors, e.g. biosensors
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    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/14—Macromolecular compounds
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    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/14—Macromolecular compounds
    • C09K2211/1441—Heterocyclic

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Polyethers (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA3020926A 2016-04-15 2017-04-14 Photoactive macromolecules and uses thereof Active CA3020926C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662323444P 2016-04-15 2016-04-15
US62/323,444 2016-04-15
PCT/US2017/027611 WO2017180998A2 (en) 2016-04-15 2017-04-14 Photoactive macromolecules and uses thereof

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CA3020926A1 CA3020926A1 (en) 2017-10-19
CA3020926C true CA3020926C (en) 2024-04-02

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US (3) US11208527B2 (https=)
EP (5) EP4407013B1 (https=)
JP (6) JP6882331B2 (https=)
KR (5) KR102836360B1 (https=)
CN (3) CN113801296B (https=)
AU (3) AU2017250778B2 (https=)
BR (1) BR112018071026B1 (https=)
CA (1) CA3020926C (https=)
ES (4) ES3046711T3 (https=)
WO (1) WO2017180998A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022104147A1 (en) 2020-11-13 2022-05-19 Beckman Coulter, Inc. Additives for reducing non-specific interactions between fluorescent polymer conjugates and cells in a biological sample
AU2017250778B2 (en) 2016-04-15 2021-09-23 Beckman Coulter, Inc. Photoactive macromolecules and uses thereof
JP7097885B2 (ja) 2016-12-12 2022-07-08 ベクトン・ディキンソン・アンド・カンパニー 水溶性ポリマー色素
CN119286279A (zh) 2017-12-26 2025-01-10 贝克顿·迪金森公司 深紫外线可激发的水溶剂化聚合物染料
US11773211B2 (en) 2018-05-05 2023-10-03 University Of Southern Mississippi Open-shell conjugated polymer conductors, composites, and compositions
JP2021533240A (ja) * 2018-08-07 2021-12-02 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company ペンダント狭発光アクセプタを有するポリマータンデム色素
WO2020106361A2 (en) 2018-09-21 2020-05-28 Joshua Tropp Thiol-based post-modification of conjugated polymers
US11584825B2 (en) 2018-12-14 2023-02-21 Beckman Coulter, Inc. Polymer dye modification and applications
US11781986B2 (en) 2019-12-31 2023-10-10 University Of Southern Mississippi Methods for detecting analytes using conjugated polymers and the inner filter effect
EP3916393B1 (en) * 2020-05-27 2023-01-25 Miltenyi Biotec B.V. & Co. KG Method for detection of cells by repetitive staining and destaining
AU2022216619A1 (en) 2021-02-05 2023-09-07 Beckman Coulter, Inc. Compositions and methods for preventing non-specific interactions between polymer dyes-antibody conjugates
CN117255832A (zh) * 2021-05-04 2023-12-19 贝克曼库尔特有限公司 紫外吸收聚合物、组合物及其用途
AU2022269592A1 (en) 2021-05-04 2023-10-05 Beckman Coulter, Inc. Uv-absorbing polymers, compositions and uses thereof
US20240400893A1 (en) 2021-09-30 2024-12-05 Beckman Coulter, Inc. Water-soluble tetrahydropyrene based fluorescent polymers
CA3237877A1 (en) 2021-11-12 2023-05-19 Aditya JARARE Novel formulation for drying of polymer dye conjugated antibodies
US20250383357A1 (en) 2022-07-01 2025-12-18 Beckman Coulter, Inc. Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
WO2024044327A1 (en) 2022-08-26 2024-02-29 Beckman Coulter, Inc. Dhnt monomers and polymer dyes with modified photophysical properties
EP4680677A1 (en) 2023-03-17 2026-01-21 Beckman Coulter, Inc. Benzothienopyrrole cyanine dyes
CN121866309A (zh) 2023-09-21 2026-04-14 贝克曼库尔特有限公司 用于流式细胞术的二氢菲（dhp）桥接染料

Family Cites Families (239)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL96874C (https=) 1954-04-03
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4703004A (en) 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
DE3408028A1 (de) 1984-03-05 1985-09-12 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe Verwendung von substituierten und unsubstituierten ringueberbrueckten para-oligophenylenen als uv-laserfarbstoffe
US6086737A (en) 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
GB8504702D0 (en) 1985-02-23 1985-03-27 Zyma Sa Tricyclic compounds
DE3815826A1 (de) 1988-05-09 1989-11-23 Henkel Kgaa Verfahren zur herstellung von vicinal diacyloxysubstituierten verbindungen
US5470829A (en) 1988-11-17 1995-11-28 Prisell; Per Pharmaceutical preparation
WO1990006952A1 (fr) 1988-12-22 1990-06-28 Kirin-Amgen, Inc. Facteur de stimulation de colonies de granulocytes modifies chimiquement
US5089261A (en) 1989-01-23 1992-02-18 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
ES2136595T5 (es) 1989-04-19 2004-04-01 Enzon, Inc. Carbonatos activos de oxidos de polialquileno para la modificacion de polipeptidos.
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
IL90193A (en) 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
JP3010067B2 (ja) * 1989-09-06 2000-02-14 トロピックス・インコーポレーテッド 安定で水溶性の化学発光性１、２―ジオキセタンおよびそれらの中間体の合成法
US5225584A (en) 1989-09-06 1993-07-06 Tropix, Inc. Synthesis of stable water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
US5650388A (en) 1989-11-22 1997-07-22 Enzon, Inc. Fractionated polyalkylene oxide-conjugated hemoglobin solutions
US5312808A (en) 1989-11-22 1994-05-17 Enzon, Inc. Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
NL194941C (nl) 1990-02-15 2003-08-04 Cordis Corp Werkwijze voor het aanbrengen van een fysiologisch actieve verbinding op een substraatoppervlak.
US5171264A (en) 1990-02-28 1992-12-15 Massachusetts Institute Of Technology Immobilized polyethylene oxide star molecules for bioapplications
US5275838A (en) 1990-02-28 1994-01-04 Massachusetts Institute Of Technology Immobilized polyethylene oxide star molecules for bioapplications
US5723218A (en) 1990-04-16 1998-03-03 Molecular Probes, Inc. Dipyrrometheneboron difluoride labeled flourescent microparticles
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5219564A (en) 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
WO1992000748A1 (en) 1990-07-06 1992-01-23 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
FR2672053B1 (fr) 1991-01-30 1993-04-23 Atochem Polyether bloc amides, leur procede de synthese.
FR2673946B1 (fr) 1991-03-15 1993-05-28 Atochem Polyether bloc amides, leur procede de synthese.
JPH06506217A (ja) 1991-03-18 1994-07-14 エンゾン，インコーポレーテッド ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体
US5187288A (en) 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
US5281698A (en) 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
US5576424A (en) 1991-08-23 1996-11-19 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
CA2119126C (en) 1991-09-16 1996-09-03 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes
AU660534B2 (en) 1992-02-13 1995-06-29 Novo Nordisk A/S Polyethylene or polypropylene glycol containing polymer
AU5006993A (en) 1992-08-21 1994-03-15 Enzon, Inc. Novel attachment of polyalkylene oxides to bio-effecting substances
US5614549A (en) 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
US5298643A (en) 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
US5349001A (en) 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5658751A (en) 1993-04-13 1997-08-19 Molecular Probes, Inc. Substituted unsymmetrical cyanine dyes with selected permeability
AU7109494A (en) 1993-06-16 1995-01-03 Enzon, Inc. Conjugated biodhesives
US5965566A (en) 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5880131A (en) 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5840900A (en) 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5605976A (en) 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5618528A (en) 1994-02-28 1997-04-08 Sterling Winthrop Inc. Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
AU2826495A (en) 1994-06-02 1996-01-04 Enzon, Inc. Method of solubilizing substantially water insoluble materials
US5730990A (en) 1994-06-24 1998-03-24 Enzon, Inc. Non-antigenic amine derived polymers and polymer conjugates
US5453505A (en) 1994-06-30 1995-09-26 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
DE4431039A1 (de) 1994-09-01 1996-03-07 Hoechst Ag Poly(4,5,9,10-tetrahydropyren-2,7-diyl)-Derivate und ihre Verwendung als Elektrolumineszenzmaterialien
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5656449A (en) 1995-03-06 1997-08-12 Molecular Probes, Inc. Neutral unsymmetrical cyanine dyes
US5756593A (en) 1995-05-15 1998-05-26 Enzon, Inc. Method of preparing polyalkyene oxide carboxylic acids
US5798276A (en) 1995-06-07 1998-08-25 Molecular Probes, Inc. Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
US6596522B2 (en) 1997-05-08 2003-07-22 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
CA2226299A1 (en) 1995-08-11 1997-02-27 Dendritech, Inc. Hyper comb-branched polymer conjugates
US6004536A (en) 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty
WO1997022371A1 (en) 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
US6162931A (en) 1996-04-12 2000-12-19 Molecular Probes, Inc. Fluorinated xanthene derivatives
US6005113A (en) 1996-05-15 1999-12-21 Molecular Probes, Inc. Long wavelength dyes for infrared tracing
US5846737A (en) 1996-07-26 1998-12-08 Molecular Probes, Inc. Conjugates of sulforhodamine fluorophores with enhanced fluorescence
EP0964702B1 (en) 1996-08-02 2006-10-04 Ortho-McNeil Pharmaceutical, Inc. Polypeptides having a single covalently bound n-terminal water-soluble polymer
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
EP0979102A4 (en) 1997-04-30 2005-11-23 Enzon Inc DETAILED POLYPEPTIDE MODIFIED BY POLYALKYLENE OXIDE
WO1998051757A1 (en) 1997-05-15 1998-11-19 Sanyo Electric Co., Ltd. Organic electroluminescence element
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US6011042A (en) 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US6111107A (en) 1997-11-20 2000-08-29 Enzon, Inc. High yield method for stereoselective acylation of tertiary alcohols
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
WO1999030727A1 (en) 1997-12-17 1999-06-24 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6180095B1 (en) 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US5965119A (en) 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
JP4078032B2 (ja) 1998-03-12 2008-04-23 ネクター セラピューティックス エイエル，コーポレイション 近位の反応性基を持つポリ（エチレングリコール）誘導体
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
JP2000063690A (ja) 1998-08-21 2000-02-29 Konica Corp 新規化合物、それを含有するハロゲン化銀乳剤、ハロゲン化銀感光材料、熱現像銀塩写真感光材料、光記録媒体及び画像形成方法
JP2002528723A (ja) 1998-10-27 2002-09-03 モレキュラー・プロウブズ・インコーポレーテッド 遷移金属錯体を含有する発光タンパク質染色剤
WO2000064988A1 (en) 1999-04-23 2000-11-02 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
TW484341B (en) 1999-08-03 2002-04-21 Sumitomo Chemical Co Polymeric fluorescent substance and polymer light emitting device
JP4605412B2 (ja) 1999-08-27 2011-01-05 Ｄｉｃ株式会社 フェナントレン及びフルオレン誘導体
DK1455839T3 (da) 1999-10-08 2013-05-06 Nektar Therapeutics Heterobifunktioneller poly(ethylenglycol)-derivater og fremgangsmåder til fremstilling heraf
US7102024B1 (en) * 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
US6579718B1 (en) 2000-08-04 2003-06-17 Molecular Probes, Inc. Carbazolylvinyl dye protein stains
EP1311487B1 (en) 2000-08-04 2008-11-26 Molecular Probes, Inc. Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
CA2423806C (en) 2000-09-29 2009-12-22 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
KR100865775B1 (ko) 2000-11-20 2008-10-29 메르크 파텐트 게엠베하 키랄 광이성질성 화합물
US6972326B2 (en) 2001-12-03 2005-12-06 Molecular Probes, Inc. Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes
CA2365814C (en) 2001-12-21 2009-05-12 American Dye Source, Inc. Photoluminescent markers and methods for detection of such markers
SE0201468D0 (sv) 2002-05-13 2002-05-13 Peter Aasberg Metod att använda luminescenta polymerer för detektion av biospecifik växelverkan
US9371559B2 (en) 2002-06-20 2016-06-21 The Regents Of The University Of California Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US7144950B2 (en) 2003-09-17 2006-12-05 The Regents Of The University Of California Conformationally flexible cationic conjugated polymers
CN1675377B (zh) 2002-06-20 2012-10-03 加州大学评议会 利用获取光的多发色团检测和分析多核苷酸的方法和组合物
US10001475B2 (en) 2002-06-20 2018-06-19 The Regents Of The University Of California Light harvesting multichromophore compositions and methods of using the same
BR0312780A (pt) 2002-07-19 2005-05-03 Pharmacia Corp Compostos de tiofeno-carboxamida substituìda para o tratamento de inflamação
US6562982B1 (en) 2002-07-25 2003-05-13 Xerox Corporation Carbazole compounds
US6670054B1 (en) 2002-07-25 2003-12-30 Xerox Corporation Electroluminescent devices
US20040101909A1 (en) 2002-08-20 2004-05-27 Hema-Quebec, 2535 Boul. Laurier, Ste-Foy, Quebec, Canada G1V 4M3 Purification of polyreactive autoantibodies and uses thereof
KR20050055717A (ko) 2002-08-26 2005-06-13 더 리전츠 오브 더 유니버시티 오브 캘리포니아 집광 다발색단을 사용하여 폴리뉴클레오티드를 검출 및 분석하기 위한 방법 및 조성물
US7563907B2 (en) 2002-12-05 2009-07-21 Dyomics Gmbh Compounds based on polymethines
ES2440920T3 (es) 2003-02-13 2014-01-31 The Regents Of The University Of California Métodos y composiciones para la detección y análisis de interacciones de proteínas que se unen a polinucleótidos utilizando multicromóforos captadores de luz
EP1650202A4 (en) 2003-07-31 2007-04-04 Taisho Pharmaceutical Co Ltd 4.5-dihydronaphtho [1,2-B] thiophene
DE10337346A1 (de) 2003-08-12 2005-03-31 Covion Organic Semiconductors Gmbh Konjugierte Polymere enthaltend Dihydrophenanthren-Einheiten und deren Verwendung
US7767785B2 (en) 2003-09-20 2010-08-03 Merck Patent Gmbh Conjugated polymers, their preparation and use thereof
US7488753B2 (en) 2003-10-09 2009-02-10 Pacific Arrow Limited Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof
JP2005139126A (ja) 2003-11-07 2005-06-02 Konica Minolta Medical & Graphic Inc 蛍光造影剤及び体外蛍光造影方法
EP2607431B1 (en) 2003-12-05 2016-08-24 Life Technologies Corporation Cyanine dye compounds
KR20060134068A (ko) 2004-02-18 2006-12-27 토쿄고교 다이가꾸 다이할로젠화물, 고분자 화합물 및 그의 제조방법
WO2005100437A1 (ja) * 2004-04-14 2005-10-27 Kanazawa University Technology Licensing Organization Ltd. 特異な発光性を示すポリフルオレン誘導体およびその製造法
DE102004020298A1 (de) 2004-04-26 2005-11-10 Covion Organic Semiconductors Gmbh Elektrolumineszierende Polymere und deren Verwendung
DE102004020299A1 (de) 2004-04-26 2005-12-01 Covion Organic Semiconductors Gmbh Konjugierte Polymere, deren Darstellung und Verwendung
CN1594314A (zh) 2004-06-24 2005-03-16 复旦大学 基于芴的水溶性共轭聚合物及其制备方法
DK1791565T3 (en) 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
EP1645610A1 (de) 2004-10-11 2006-04-12 Covion Organic Semiconductors GmbH Phenanthren-Derivate
DE112005002495B4 (de) 2004-10-11 2016-11-17 Cambridge Display Technology Ltd. Polares halbleitendes Lochtransportmaterial
US20060094859A1 (en) 2004-11-03 2006-05-04 Marrocco Matthew L Iii Class of bridged biphenylene polymers
US20060160109A1 (en) 2004-11-22 2006-07-20 Odyssey Thera, Inc. Harnessing network biology to improve drug discovery
US7897684B2 (en) 2005-01-10 2011-03-01 The Regents Of The University Of California Conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
WO2006080406A1 (ja) 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 三環性化合物
US7666594B2 (en) 2005-01-31 2010-02-23 The Regents Of The University Of California Methods for assaying a sample for an aggregant
US8354249B2 (en) 2005-08-11 2013-01-15 Omrix Biopharmaceuticals Ltd. Intravenous immunoglobulin composition
DE102006038683A1 (de) 2006-08-17 2008-02-21 Merck Patent Gmbh Konjugierte Polymere, deren Darstellung und Verwendung
KR20090053863A (ko) 2006-09-15 2009-05-27 지멘스 메디컬 솔루션즈 유에스에이, 인크. 인테그린에 대한 이미지화제로서 클릭 화학반응-유래된 시클로펩티드 유도체
US8158444B2 (en) 2006-10-06 2012-04-17 Sirigen, Inc. Fluorescent methods and materials for directed biomarker signal amplification
DE102007002714A1 (de) 2007-01-18 2008-07-31 Merck Patent Gmbh Neue Materialien für organische Elektrolumineszenzvorrichtungen
JP2008290963A (ja) 2007-05-24 2008-12-04 Nippon Kayaku Co Ltd 芳香族化合物の製造方法
JP2011500916A (ja) 2007-10-17 2011-01-06 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 親水性と疎水性のバランスがとれた水溶性蛍光物質
WO2009121244A1 (en) * 2008-04-03 2009-10-08 Versitech Limited Fluorophore compounds
US8114904B2 (en) * 2008-04-05 2012-02-14 Versitech Limited & Morningside Ventures Limited Luminescence quenchers and fluorogenic probes for detection of reactive species
KR20110040857A (ko) 2008-06-23 2011-04-20 바스프 에스이 신규한 중합체
DE102008049037A1 (de) 2008-09-25 2010-04-22 Merck Patent Gmbh Neue Polymere mit niedriger Polydispersität
WO2022104147A1 (en) 2020-11-13 2022-05-19 Beckman Coulter, Inc. Additives for reducing non-specific interactions between fluorescent polymer conjugates and cells in a biological sample
US20100150942A1 (en) 2008-12-03 2010-06-17 Cantor Thomas L Affinity purified human polyclonal antibodies and methods of making and using them
JP2010143895A (ja) 2008-12-22 2010-07-01 Nard Inst Ltd ピセン化合物の製造方法およびピセン化合物の結晶体
WO2010075514A1 (en) * 2008-12-23 2010-07-01 Michigan Technological University Fluorescent conjugated polymers with a bodipy-based backbone and uses thereof
JP5388030B2 (ja) 2009-02-27 2014-01-15 国立大学法人広島大学 芳香族化合物の製造方法
US8431416B2 (en) 2009-04-01 2013-04-30 Becton, Dickinson And Company Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates
JP5438363B2 (ja) 2009-04-24 2014-03-12 ウシオケミックス株式会社 バンドギャップが広いことを特徴とする有機半導体材料
SG177355A1 (en) * 2009-06-26 2012-02-28 Sirigen Inc Signal amplified biological detection with conjugated polymers
JP2011046662A (ja) 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
CN103880860B (zh) 2009-08-28 2017-05-17 帝人株式会社 新型加成化合物及其制造方法
JP5478189B2 (ja) 2009-10-16 2014-04-23 学校法人東海大学 大気安定性に優れた有機トランジスタ
US8350038B2 (en) * 2009-10-20 2013-01-08 Roche Diagnostics Operations, Inc. Fluorescence quencher molecules
CA2786713C (en) 2010-01-19 2018-03-06 Sirigen Group Limited Novel reagents for directed biomarker signal amplification
CN102770465B (zh) * 2010-03-22 2015-04-22 汉高美国知识产权有限责任公司 大分子光引发剂及其可固化组合物
KR20110113297A (ko) 2010-04-09 2011-10-17 다우어드밴스드디스플레이머티리얼 유한회사 신규한 유기 전자재료용 화합물 및 이를 포함하는 유기 전계 발광 소자
CA2799540A1 (en) 2010-06-08 2011-12-15 Genentech, Inc. Cysteine engineered antibodies and conjugates
JP2011256144A (ja) 2010-06-10 2011-12-22 Yamamoto Chem Inc チオフェン化合物の製造方法
US8623324B2 (en) 2010-07-21 2014-01-07 Aat Bioquest Inc. Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
CN102146077B (zh) 2011-01-13 2014-10-01 上海大学 芴并咪唑衍生物及其制备方法
US9971998B2 (en) 2011-02-25 2018-05-15 Paypal, Inc. Location-based automatic payment system
KR101983991B1 (ko) 2011-04-13 2019-05-30 에스에프씨 주식회사 축합아릴 화합물 및 이를 포함하는 유기전계발광소자
KR101793428B1 (ko) 2011-04-13 2017-11-03 에스에프씨 주식회사 축합아릴 화합물 및 이를 포함하는 유기전계발광소자
KR101996648B1 (ko) 2011-04-15 2019-07-04 에스에프씨 주식회사 신규한 화합물 및 이를 포함하는 유기전계발광소자
KR101923936B1 (ko) 2011-04-29 2018-11-30 에스에프씨 주식회사 신규한 화합물 및 이를 포함하는 유기전계발광소자
ES2715832T3 (es) 2011-05-27 2019-06-06 Lexicon Pharmaceuticals Inc Inhibidores a base de 4H-tieno[3,2-c]-cromeno de pectina acetilesterasa de notum y métodos de utilización de los mismos
CN102267948B (zh) 2011-06-17 2013-09-04 上海大学 芴并二咪唑衍生物及其制备方法
US8623332B2 (en) 2011-07-06 2014-01-07 Fertin Pharma A/S Chewing gum having sustained release of nicotine
US20130108619A1 (en) 2011-11-02 2013-05-02 Isaac Melamed Intravenous immunoglobulin processing, diagnostic, and treatment systems and methods
US20130177574A1 (en) 2012-01-11 2013-07-11 Paul I. Terasaki Foundation Laboratory ANTI-HLA CLASS-Ib ANTIBODIES MIMIC IMMUNOREACTIVITY AND IMMUNOMODULATORY FUNCTIONS OF INTRAVENOUS IMMUNOGLOBULIN (IVIg) USEFUL AS THERAPEUTIC IVIg MIMETICS AND METHODS OF THEIR USE
AU2013217224B2 (en) 2012-02-10 2017-04-06 Lupin Limited Antiviral compounds with a dibenzooxaheterocycle moiety
US9206271B2 (en) * 2012-03-25 2015-12-08 Wisconsin Alumni Research Foundation Fully backbone degradable and functionalizable polymers derived from the ring-opening metathesis polymerization (ROMP)
US9933341B2 (en) 2012-04-05 2018-04-03 Becton, Dickinson And Company Sample preparation for flow cytometry
WO2013183549A1 (ja) 2012-06-04 2013-12-12 住友化学株式会社 組成物及びそれを用いた電子素子
KR101488564B1 (ko) 2012-09-11 2015-02-02 주식회사 두산 유기발광 화합물 및 이를 이용한 유기 전계 발광 소자
JP6071398B2 (ja) 2012-10-05 2017-02-01 キヤノン株式会社 インデノ［１，２−ｂ］フェナンスレン化合物及びこれを有する有機発光素子
BR112015003160A2 (pt) 2012-10-24 2017-07-04 Becton Dickinson Co corantes de azaindolina - cianina substituídos por hidroxamato e bioconjugados dos mesmos
CA2900710C (en) 2013-02-08 2023-08-08 General Mills, Inc. Reduced sodium food products
US9977014B2 (en) 2013-05-10 2018-05-22 Agency For Science, Technology And Research Nanoparticle sensor for nucleic acid-protein interaction
US10240000B2 (en) 2013-09-26 2019-03-26 Polyone Corporation Aromatic polyimides suitable for 3D printing processes
JP6247560B2 (ja) 2014-02-20 2017-12-13 富士フイルム株式会社 有機薄膜トランジスタ、有機半導体薄膜および有機半導体材料
JP6140626B2 (ja) 2014-03-03 2017-05-31 富士フイルム株式会社 有機薄膜トランジスタ及びその製造方法
JP6106114B2 (ja) 2014-03-03 2017-03-29 富士フイルム株式会社 有機薄膜トランジスタ及びその製造方法
JP6110802B2 (ja) 2014-03-07 2017-04-05 富士フイルム株式会社 薄膜トランジスタ
JP6247583B2 (ja) 2014-03-28 2017-12-13 富士フイルム株式会社 有機トランジスタの有機半導体膜形成用組成物、パターン形成方法
JP6152357B2 (ja) 2014-03-28 2017-06-21 富士フイルム株式会社 有機トランジスタの有機半導体膜形成用組成物、パターン形成方法
JP2015192119A (ja) 2014-03-28 2015-11-02 富士フイルム株式会社 有機半導体膜の形成方法
JP6239457B2 (ja) 2014-07-18 2017-11-29 富士フイルム株式会社 有機半導体膜形成用組成物、及び、有機半導体素子の製造方法
WO2016009892A1 (ja) 2014-07-18 2016-01-21 富士フイルム株式会社 有機半導体膜形成用組成物、並びに、有機半導体素子及びその製造方法
JP6235143B2 (ja) 2014-07-18 2017-11-22 富士フイルム株式会社 有機半導体膜形成用組成物、及び、有機半導体素子の製造方法
EP3171420A4 (en) 2014-07-18 2017-07-05 Fujifilm Corporation Organic semiconductor film formation composition, organic semiconductor element, and production method therefor
CZ2014527A3 (cs) 2014-08-05 2016-02-17 Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. Způsob detekce aktivní formy analytů ve vzorku a stanovení schopnosti dalších látek vázat se do aktivních míst těchto analytů
WO2016052056A1 (ja) 2014-09-29 2016-04-07 富士フイルム株式会社 有機半導体組成物、及び、有機半導体素子
WO2016052254A1 (ja) 2014-09-30 2016-04-07 富士フイルム株式会社 有機半導体膜形成用組成物、並びに、有機半導体素子及びその製造方法
EP3215515A1 (en) 2014-11-03 2017-09-13 Life Technologies Corporation Dibenzosilole monomers and polymers and methods for their preparation and use
CN104557723A (zh) 2014-11-05 2015-04-29 上海大学 不对称芴并咪唑衍生物及其制备方法
CN105585589B (zh) 2014-11-12 2018-10-23 中国中化股份有限公司 一种可溶性并苯化合物及其制备方法和应用
JP6318452B2 (ja) 2015-01-19 2018-05-09 富士フイルム株式会社 有機薄膜トランジスタ及びその製造方法
CN107428918B (zh) 2015-03-12 2021-07-30 贝克顿·迪金森公司 紫外线吸收聚合物染料及其使用方法
WO2016144652A1 (en) 2015-03-12 2016-09-15 Becton, Dickinson And Company Polymeric bodipy dyes and methods for using the same
JP6484700B2 (ja) 2015-03-13 2019-03-13 富士フイルム株式会社 有機半導体膜形成用組成物、有機薄膜トランジスタ、電子ペーパー、および、ディスプレイデバイス
EP3242339A4 (en) 2015-03-17 2018-01-24 Fujifilm Corporation Organic semiconductor composition and method for manufacturing organic semiconductor element
EP3319138B1 (en) 2015-06-30 2019-07-24 FUJIFILM Corporation Photoelectric conversion element, and solar battery using same
KR102502117B1 (ko) 2015-07-16 2023-02-22 에스에프씨 주식회사 염료 화합물
JP7034078B2 (ja) 2015-10-23 2022-03-11 イーアールエックス ファーマシューティカルズ インコーポレイテッド セラストロールの類似体
JP6484724B2 (ja) 2015-11-20 2019-03-13 富士フイルム株式会社 有機半導体組成物、有機半導体膜、有機薄膜トランジスタおよび有機薄膜トランジスタの製造方法
WO2017105927A1 (en) 2015-12-16 2017-06-22 Becton, Dickinson And Company Polymeric dye ratiometric sensor for analyte detection and methods of using the same
WO2017105928A1 (en) 2015-12-16 2017-06-22 Becton, Dickinson And Company Photostable fluorescent polymeric tandem dyes including luminescent metal complexes
KR102042191B1 (ko) 2016-03-23 2019-11-07 삼성에스디아이 주식회사 유기 화합물, 유기 광전자 소자 및 표시 장치
WO2017172608A1 (en) 2016-03-28 2017-10-05 Aat Bioquest, Inc. Polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection
AU2017250778B2 (en) 2016-04-15 2021-09-23 Beckman Coulter, Inc. Photoactive macromolecules and uses thereof
JP7173867B2 (ja) 2016-04-22 2022-11-16 ベクトン・ディキンソン・アンド・カンパニー 多重高分子色素デバイス及びその使用方法
CN106008138B (zh) 2016-05-23 2019-04-09 中节能万润股份有限公司 一种有机电致发光材料、应用及发光器件
CN109661439A (zh) 2016-07-07 2019-04-19 贝克顿·迪金森公司 发荧光的水溶剂化共轭聚合物
WO2018009861A1 (en) 2016-07-08 2018-01-11 Biolegend Substituted polyfluorene compounds
EP3481900A4 (en) 2016-07-11 2020-03-18 Becton, Dickinson and Company BLUE-EXCITABLE WATER-SOLUBLE POLYMERIC DYES
KR101815773B1 (ko) * 2016-07-18 2018-01-05 건국대학교 산학협력단 전하수송층을 포함하는 유기 광전변환 소자 및 이의 제조방법
KR102659149B1 (ko) 2016-09-06 2024-04-19 에스에프씨 주식회사 신규한 유기 화합물 및 이를 포함하는 유기 발광 소자
JP7097885B2 (ja) 2016-12-12 2022-07-08 ベクトン・ディキンソン・アンド・カンパニー 水溶性ポリマー色素
CN110337331B (zh) 2017-02-08 2022-04-26 贝克顿·迪金森公司 干染料试剂装置以及制造和使用所述干染料试剂装置的方法
US10870668B2 (en) 2017-05-05 2020-12-22 Universal Display Corporation Organic electroluminescent materials and devices
JP2019006739A (ja) 2017-06-28 2019-01-17 山本化成株式会社 チオフェン化合物の製造方法
EP3658648B1 (en) 2017-07-28 2021-10-27 BioLegend, Inc. Conjugated polymers and methods of use
CN107973795A (zh) 2017-11-23 2018-05-01 李现伟 一种有机电致发光材料、发光器件及显示器
CN108129496A (zh) 2017-12-01 2018-06-08 阜阳欣奕华材料科技有限公司 一种化合物、有机电致发光器件及显示装置
CN119286279A (zh) 2017-12-26 2025-01-10 贝克顿·迪金森公司 深紫外线可激发的水溶剂化聚合物染料
EP3775052B1 (en) 2018-03-30 2024-06-05 Becton, Dickinson and Company Water-soluble polymeric dyes having pendant chromophores
KR102216472B1 (ko) 2018-06-08 2021-02-17 삼성에스디아이 주식회사 유기 광전자 소자용 화합물, 유기 광전자 소자용 조성물, 유기 광전자 소자 및 표시 장치
JP2021533240A (ja) 2018-08-07 2021-12-02 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company ペンダント狭発光アクセプタを有するポリマータンデム色素
EP3636635A1 (en) 2018-10-11 2020-04-15 Academisch Ziekenhuis Leiden h.o.d.n. LUMC Imaging agents
US11992844B2 (en) 2018-11-13 2024-05-28 Becton, Dickinson And Company Dried reagent strainers and methods for making and using the same
US11584825B2 (en) 2018-12-14 2023-02-21 Beckman Coulter, Inc. Polymer dye modification and applications
US11220628B2 (en) 2019-02-20 2022-01-11 Aat Bioquest, Inc. Condensed polycyclic conjugated polymers and their use for biological detection
EP4047057A4 (en) 2019-11-19 2024-01-17 SFC Co., Ltd. EXTINGUISHER AND ITS USES
WO2021252368A1 (en) 2020-06-08 2021-12-16 Biotium, Inc. Fluorenyl cyanine dyes
US20230287170A1 (en) 2020-07-16 2023-09-14 Miltenyi Biotec B.V. & Co. KG Fluorescent dyes comprising m-conjugated 1,1 -binaphthyl-based polymers
US12169166B2 (en) 2021-02-16 2024-12-17 Aat Bioquest, Inc. Fluorogenic cyanine compounds for detecting nucleic acids
WO2022216450A1 (en) 2021-04-07 2022-10-13 Becton, Dickinson And Company Water-soluble fluorescent polymeric dyes
WO2022216449A1 (en) 2021-04-07 2022-10-13 Becton, Dickinson And Company Water-soluble yellow green absorbing dyes
AU2022269592A1 (en) 2021-05-04 2023-10-05 Beckman Coulter, Inc. Uv-absorbing polymers, compositions and uses thereof
US20240400893A1 (en) 2021-09-30 2024-12-05 Beckman Coulter, Inc. Water-soluble tetrahydropyrene based fluorescent polymers
US20230399565A1 (en) 2022-06-09 2023-12-14 Beckman Coulter, Inc. Polymer dyes and uses thereof

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