CA2879997A1 - Inducible dna binding proteins and genome perturbation tools and applications thereof - Google Patents

Inducible dna binding proteins and genome perturbation tools and applications thereof Download PDF

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Publication number
CA2879997A1
CA2879997A1 CA2879997A CA2879997A CA2879997A1 CA 2879997 A1 CA2879997 A1 CA 2879997A1 CA 2879997 A CA2879997 A CA 2879997A CA 2879997 A CA2879997 A CA 2879997A CA 2879997 A1 CA2879997 A1 CA 2879997A1
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Prior art keywords
domain
tale
histone
dna
crispr
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Abandoned
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CA2879997A
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English (en)
French (fr)
Inventor
Feng Zhang
Mark BRIGHAM
Le Cong
Silvana KONERMANN
Neville Espi Sanjana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Broad Institute Inc
Harvard University
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Massachusetts Institute of Technology
Broad Institute Inc
Harvard University
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48914461&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2879997(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Institute of Technology, Broad Institute Inc, Harvard University filed Critical Massachusetts Institute of Technology
Publication of CA2879997A1 publication Critical patent/CA2879997A1/en
Abandoned legal-status Critical Current

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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Virology (AREA)
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  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2879997A 2012-07-25 2013-07-21 Inducible dna binding proteins and genome perturbation tools and applications thereof Abandoned CA2879997A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201261675778P 2012-07-25 2012-07-25
US61/675,778 2012-07-25
US201261721283P 2012-11-01 2012-11-01
US61/721,283 2012-11-01
US201261736465P 2012-12-12 2012-12-12
US61/736,465 2012-12-12
US201361794458P 2013-03-15 2013-03-15
US61/794,458 2013-03-15
US201361835973P 2013-06-17 2013-06-17
US61/835,973 2013-06-17
PCT/US2013/051418 WO2014018423A2 (en) 2012-07-25 2013-07-21 Inducible dna binding proteins and genome perturbation tools and applications thereof

Publications (1)

Publication Number Publication Date
CA2879997A1 true CA2879997A1 (en) 2014-01-30

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CA2879997A Abandoned CA2879997A1 (en) 2012-07-25 2013-07-21 Inducible dna binding proteins and genome perturbation tools and applications thereof

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US (4) US20150291966A1 (cg-RX-API-DMAC7.html)
EP (3) EP3808844A1 (cg-RX-API-DMAC7.html)
JP (2) JP2015527889A (cg-RX-API-DMAC7.html)
KR (2) KR102530118B1 (cg-RX-API-DMAC7.html)
CN (2) CN116622704A (cg-RX-API-DMAC7.html)
AU (3) AU2013293270B2 (cg-RX-API-DMAC7.html)
CA (1) CA2879997A1 (cg-RX-API-DMAC7.html)
DK (1) DK3494997T3 (cg-RX-API-DMAC7.html)
ES (1) ES2757623T3 (cg-RX-API-DMAC7.html)
PL (1) PL3494997T3 (cg-RX-API-DMAC7.html)
PT (1) PT3494997T (cg-RX-API-DMAC7.html)
WO (1) WO2014018423A2 (cg-RX-API-DMAC7.html)

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CN110373459A (zh) * 2019-06-27 2019-10-25 郑湘榕 基于STIP1基因rs2236647位点用于儿童哮喘病检测的试剂、试剂盒及应用
CN111500569A (zh) * 2014-03-05 2020-08-07 国立大学法人神户大学 特异性转变靶向dna序列的核酸碱基的基因组序列的修饰方法、及其使用的分子复合体
CN111849991A (zh) * 2020-08-05 2020-10-30 武汉纽福斯生物科技有限公司 一种寡核苷酸及其应用
CN113178263A (zh) * 2021-04-30 2021-07-27 上海市公共卫生临床中心 肺结核病变活动性标志物、试剂盒、方法及模型构建方法
CN114814217A (zh) * 2021-01-19 2022-07-29 首都医科大学附属北京世纪坛医院 磷脂酰肌醇聚糖特异性磷脂酶d及其多肽片段在淋巴水肿中的应用
CN119818681A (zh) * 2025-01-07 2025-04-15 重庆医科大学附属第二医院 Pax 9激动剂在制备预防或治疗头颈部鳞状细胞癌中的应用

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