BRPI0809366B8 - polipeptídeo substancialmente alfa-helicoidal, método para fabricação do mesmo, aminoácido e composição farmacêutica - Google Patents

polipeptídeo substancialmente alfa-helicoidal, método para fabricação do mesmo, aminoácido e composição farmacêutica

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Publication number
BRPI0809366B8
BRPI0809366B8 BRPI0809366A BRPI0809366A BRPI0809366B8 BR PI0809366 B8 BRPI0809366 B8 BR PI0809366B8 BR PI0809366 A BRPI0809366 A BR PI0809366A BR PI0809366 A BRPI0809366 A BR PI0809366A BR PI0809366 B8 BRPI0809366 B8 BR PI0809366B8
Authority
BR
Brazil
Prior art keywords
amino acid
pharmaceutical composition
manufacturing same
helical polypeptide
substantially alpha
Prior art date
Application number
BRPI0809366A
Other languages
English (en)
Inventor
L Verdine Gregory
Kim Young-Woo
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of BRPI0809366A2 publication Critical patent/BRPI0809366A2/pt
Publication of BRPI0809366A8 publication Critical patent/BRPI0809366A8/pt
Publication of BRPI0809366B1 publication Critical patent/BRPI0809366B1/pt
Publication of BRPI0809366B8 publication Critical patent/BRPI0809366B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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Abstract

polipeptídeos interligados a presente invenção fornece inventivos polipeptídeos interligados, composições farmacêuticas dos mesmos, e métodos de preparação e uso dos inventivos polipeptídeos interligados.
BRPI0809366A 2007-03-28 2008-03-28 polipeptídeo substancialmente alfa-helicoidal, método para fabricação do mesmo, aminoácido e composição farmacêutica BRPI0809366B8 (pt)

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US90856607P 2007-03-28 2007-03-28
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PCT/US2008/058575 WO2008121767A2 (en) 2007-03-28 2008-03-28 Stitched polypeptides

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BRPI0809366B1 BRPI0809366B1 (pt) 2021-02-23
BRPI0809366B8 true BRPI0809366B8 (pt) 2021-05-25

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US10301351B2 (en) 2019-05-28
AU2008232709A1 (en) 2008-10-09
US20170066799A1 (en) 2017-03-09
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JP2010522769A (ja) 2010-07-08
AU2008232709B2 (en) 2014-05-29
AU2008232709C1 (en) 2015-01-15
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KR20090126308A (ko) 2009-12-08
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CN101730708B (zh) 2013-09-18
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US20100184645A1 (en) 2010-07-22
US9556227B2 (en) 2017-01-31
BRPI0809366B1 (pt) 2021-02-23
IL201227A0 (en) 2010-05-31
BRPI0809366A8 (pt) 2019-01-29
JP5631201B2 (ja) 2014-11-26
JP2018044018A (ja) 2018-03-22
BRPI0809366A2 (pt) 2014-09-16
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EP3159352B1 (en) 2023-08-02
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