BRPI0606301A2 - processo para fabricar uma mistura de sais de acetato de polipeptìdeos, processo para fabricar uma mistura de sais de polipeptìdeos de trifluoroacetila não protegidos, mistura de sais de acetato de polipeptìdeos, composição farmacêutica, processos para a preparação de uma composição farmacêutica, e, mistura de polipeptìdeos de trifluoroacetila protegidos - Google Patents
processo para fabricar uma mistura de sais de acetato de polipeptìdeos, processo para fabricar uma mistura de sais de polipeptìdeos de trifluoroacetila não protegidos, mistura de sais de acetato de polipeptìdeos, composição farmacêutica, processos para a preparação de uma composição farmacêutica, e, mistura de polipeptìdeos de trifluoroacetila protegidosInfo
- Publication number
- BRPI0606301A2 BRPI0606301A2 BRPI0606301-2A BRPI0606301A BRPI0606301A2 BR PI0606301 A2 BRPI0606301 A2 BR PI0606301A2 BR PI0606301 A BRPI0606301 A BR PI0606301A BR PI0606301 A2 BRPI0606301 A2 BR PI0606301A2
- Authority
- BR
- Brazil
- Prior art keywords
- mixture
- polypeptide
- salts
- pharmaceutical composition
- making
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCESSO PARA FABRICAR UMA MISTURA DE SAIS DE ACETATO DE POLIPEPTìDEOS, PROCESSO PARA FABRICAR UMA MISTURA DE SAIS DE POLIPETìDEOS DE TRIFLUOROACETILA NãO PROTEGIDOS, MISTURA DE SAIS DE ACETATO DE POLIPEPTìDEOS, COMPOSIçãO FARMACêUTICA, PROCESSOS PARA A PREPARAçãO DE UMA COMPOSIçãO FARMACêUTICA, E, MISTURA DE POLIPEPTìDEOS DE TRIFLUOROACETILA PROTEGIDOS. A presente invenção diz respeito a um processo melhorado para fabricar uma mistura de sais de acetatos de polipeptídeos, cada um dos quais consistindo de ácido glutâmico, alanina, tirosina e usina, para o uso no tratamento de esclerose múltipla.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64944205P | 2005-02-02 | 2005-02-02 | |
PCT/US2006/002351 WO2006083608A1 (en) | 2005-02-02 | 2006-01-20 | Process for producing polypeptide mixtures using hydrogenolysis |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0606301A2 true BRPI0606301A2 (pt) | 2009-07-07 |
Family
ID=36777558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0606301-2A BRPI0606301A2 (pt) | 2005-02-02 | 2006-01-20 | processo para fabricar uma mistura de sais de acetato de polipeptìdeos, processo para fabricar uma mistura de sais de polipeptìdeos de trifluoroacetila não protegidos, mistura de sais de acetato de polipeptìdeos, composição farmacêutica, processos para a preparação de uma composição farmacêutica, e, mistura de polipeptìdeos de trifluoroacetila protegidos |
Country Status (16)
Country | Link |
---|---|
US (1) | US20060172942A1 (pt) |
EP (1) | EP1838326A4 (pt) |
JP (1) | JP2008528589A (pt) |
KR (1) | KR20070108388A (pt) |
CN (1) | CN101111252A (pt) |
AU (1) | AU2006211510B8 (pt) |
BR (1) | BRPI0606301A2 (pt) |
CA (1) | CA2594022A1 (pt) |
IL (1) | IL183610A0 (pt) |
MX (1) | MX2007009296A (pt) |
NO (1) | NO20074374L (pt) |
NZ (1) | NZ556156A (pt) |
RU (1) | RU2419638C2 (pt) |
UA (1) | UA93669C2 (pt) |
WO (1) | WO2006083608A1 (pt) |
ZA (1) | ZA200705874B (pt) |
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ES2527760T3 (es) * | 1998-07-23 | 2015-01-29 | Yeda Research And Development Co., Ltd. | Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos |
US6800287B2 (en) | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
CA2469393C (en) * | 2001-12-04 | 2010-05-25 | Teva Pharmaceutical Industries, Ltd. | Processes for the measurement of the potency of glatiramer acetate |
US20070244056A1 (en) * | 2004-03-03 | 2007-10-18 | Liat Hayardeny | Combination Therapy With Glatiramer Acetate and Riluzole |
US7560100B2 (en) * | 2004-09-09 | 2009-07-14 | Yeda Research And Development Co., Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases |
US7495072B2 (en) * | 2004-09-09 | 2009-02-24 | Teva Pharmaceutical Industries, Ltd. | Process for preparation of mixtures of polypeptides using purified hydrobromic acid |
US8324641B2 (en) * | 2007-06-29 | 2012-12-04 | Ledengin, Inc. | Matrix material including an embedded dispersion of beads for a light-emitting device |
US20080261894A1 (en) * | 2005-02-17 | 2008-10-23 | Rivka Kreitman | Combination Therapy with Glatiramer Acetate and Rasagiline for the Treatment of Multiple Sclerosis |
US20060240463A1 (en) * | 2005-04-25 | 2006-10-26 | Rappaport Family Institute For Research In The Medical Sciences | Markers associated with the therapeutic efficacy of glatiramer acetate |
EP2173766A1 (en) * | 2007-07-31 | 2010-04-14 | Natco Pharma Limited | Process for the preparation glatiramer acetate (copolymer-1) |
WO2009017775A2 (en) * | 2007-08-02 | 2009-02-05 | Scinopharm Taiwan Ltd. | Process for the preparation of a polypeptide |
US20090149541A1 (en) * | 2007-11-28 | 2009-06-11 | Yafit Stark | Method of delaying the onset of clinically definite multiple sclerosis |
EP2277050B2 (en) | 2008-04-16 | 2022-09-28 | Momenta Pharmaceuticals, Inc. | Analysis of amino acid copolymer compositions |
US8212002B2 (en) * | 2008-08-07 | 2012-07-03 | Scinopharm Taiwan Ltd | Synthesis of glatiramer acetate |
US9617313B2 (en) | 2008-12-24 | 2017-04-11 | Synthon Bv | Process for purifying a polymer mixture |
WO2010115175A1 (en) | 2009-04-03 | 2010-10-07 | Momenta Pharmaceticals, Inc. | Control of copolymer compositions |
DK2949335T3 (en) | 2009-08-20 | 2017-07-31 | Yeda Res & Dev | LOW FREQUENT GLATIRAMER ACETATE THERAPY |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
US9109006B2 (en) * | 2010-07-29 | 2015-08-18 | Santhanakrishnan Srinivasan | Glatiramer acetate molecular weight markers |
US8709433B2 (en) | 2010-10-11 | 2014-04-29 | Teva Pharmaceutical Industries Ltd. | Cytokine biomarkers as predictive biomarkers of clinical response for Glatiramer acetate |
ES2654291T3 (es) | 2011-02-14 | 2018-02-13 | Usv Private Limited | Copolímero-1, proceso para la preparación y sus métodos de análisis |
GB2478837A (en) * | 2011-03-14 | 2011-09-21 | Cipla Ltd | Preparation of glatiramer |
WO2013009885A2 (en) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Evaluation of copolymer diethylamide |
US8575198B1 (en) | 2011-09-07 | 2013-11-05 | Momenta Pharmaceuticals, Inc. | In-process control for the manufacture of glatiramer acetate |
TW201326399A (zh) | 2011-10-10 | 2013-07-01 | Teva Pharma | 用於預測對格拉替雷(glatiramer)醋酸鹽之臨床反應之單核苷酸多型性之判定 |
EP2906719A4 (en) | 2012-10-10 | 2016-11-09 | Teva Pharma | PREDICTIVE BIOMARKER FOR CLINICAL REACTION FOR GLATIRAMERACETATE |
WO2014060942A2 (en) * | 2012-10-20 | 2014-04-24 | Mahesh Kandula | Compositions and methods of for the treatment of multiple sclerosis and neurodegenerative diseases |
CN103265624B (zh) * | 2013-05-27 | 2015-04-22 | 成都圣诺生物制药有限公司 | 格拉替雷的制备方法 |
UY35790A (es) | 2013-10-21 | 2015-05-29 | Teva Pharma | Marcadores genéticos que predicen la respuesta al acetato de glatiramer |
US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
CN104610436A (zh) * | 2015-02-03 | 2015-05-13 | 郑州大明药物科技有限公司 | 一种醋酸格拉替雷的制备方法 |
US11167003B2 (en) | 2017-03-26 | 2021-11-09 | Mapi Pharma Ltd. | Methods for suppressing or alleviating primary or secondary progressive multiple sclerosis (PPMS or SPMS) using sustained release glatiramer depot systems |
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WO2004091573A1 (en) * | 2003-03-04 | 2004-10-28 | Teva Pharmaceutical Industries, Ltd. | Combination therapy with glatiramer acetate and alphacalcidol for the treatment of multiple sclerosis |
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US7495072B2 (en) * | 2004-09-09 | 2009-02-24 | Teva Pharmaceutical Industries, Ltd. | Process for preparation of mixtures of polypeptides using purified hydrobromic acid |
US7560100B2 (en) * | 2004-09-09 | 2009-07-14 | Yeda Research And Development Co., Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases |
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WO2007081975A2 (en) * | 2006-01-11 | 2007-07-19 | Teva Pharmaceutical Industries, Ltd. | Method of treating multiple sclerosis |
US20090149541A1 (en) * | 2007-11-28 | 2009-06-11 | Yafit Stark | Method of delaying the onset of clinically definite multiple sclerosis |
-
2006
- 2006-01-20 US US11/336,251 patent/US20060172942A1/en not_active Abandoned
- 2006-01-20 UA UAA200709785A patent/UA93669C2/ru unknown
- 2006-01-20 EP EP06719275A patent/EP1838326A4/en not_active Withdrawn
- 2006-01-20 JP JP2007553163A patent/JP2008528589A/ja active Pending
- 2006-01-20 CA CA002594022A patent/CA2594022A1/en not_active Abandoned
- 2006-01-20 CN CNA2006800035220A patent/CN101111252A/zh active Pending
- 2006-01-20 WO PCT/US2006/002351 patent/WO2006083608A1/en active Application Filing
- 2006-01-20 MX MX2007009296A patent/MX2007009296A/es not_active Application Discontinuation
- 2006-01-20 NZ NZ556156A patent/NZ556156A/en not_active IP Right Cessation
- 2006-01-20 RU RU2007132889/04A patent/RU2419638C2/ru not_active IP Right Cessation
- 2006-01-20 BR BRPI0606301-2A patent/BRPI0606301A2/pt not_active IP Right Cessation
- 2006-01-20 KR KR1020077019848A patent/KR20070108388A/ko not_active Application Discontinuation
- 2006-01-20 AU AU2006211510A patent/AU2006211510B8/en not_active Ceased
- 2006-01-20 ZA ZA200705874A patent/ZA200705874B/xx unknown
-
2007
- 2007-05-31 IL IL183610A patent/IL183610A0/en unknown
- 2007-08-28 NO NO20074374A patent/NO20074374L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2006211510B8 (en) | 2011-04-21 |
RU2007132889A (ru) | 2009-03-10 |
MX2007009296A (es) | 2007-09-21 |
NZ556156A (en) | 2010-03-26 |
AU2006211510A1 (en) | 2006-08-10 |
JP2008528589A (ja) | 2008-07-31 |
EP1838326A1 (en) | 2007-10-03 |
IL183610A0 (en) | 2008-04-13 |
EP1838326A4 (en) | 2009-09-30 |
UA93669C2 (ru) | 2011-03-10 |
CA2594022A1 (en) | 2006-08-10 |
WO2006083608A1 (en) | 2006-08-10 |
CN101111252A (zh) | 2008-01-23 |
KR20070108388A (ko) | 2007-11-09 |
RU2419638C2 (ru) | 2011-05-27 |
NO20074374L (no) | 2007-10-24 |
ZA200705874B (en) | 2009-04-29 |
US20060172942A1 (en) | 2006-08-03 |
AU2006211510B2 (en) | 2011-03-10 |
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