EA201490749A1 - Однонуклеотидные полиморфизмы, полезные для прогнозирования клинической реакции на глатирамера ацетат - Google Patents

Однонуклеотидные полиморфизмы, полезные для прогнозирования клинической реакции на глатирамера ацетат

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Publication number
EA201490749A1
EA201490749A1 EA201490749A EA201490749A EA201490749A1 EA 201490749 A1 EA201490749 A1 EA 201490749A1 EA 201490749 A EA201490749 A EA 201490749A EA 201490749 A EA201490749 A EA 201490749A EA 201490749 A1 EA201490749 A1 EA 201490749A1
Authority
EA
Eurasian Patent Office
Prior art keywords
subject
acetate
glatiramer acetate
gletyramer
nucleotic
Prior art date
Application number
EA201490749A
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English (en)
Inventor
Амир Челет
Фабио Маччарди
Джозеф Леви
Original Assignee
Тева Фармасьютикал Индастриз Лтд.
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Application filed by Тева Фармасьютикал Индастриз Лтд. filed Critical Тева Фармасьютикал Индастриз Лтд.
Publication of EA201490749A1 publication Critical patent/EA201490749A1/ru

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Изобретение относится к способу лечения человека, больного рассеянным склерозом или клиническим изолированным синдромом, указывающим на рассеянный склероз, с помощью фармацевтической композиции, содержащей глатирамера ацетат и фармацевтически приемлемый носитель, и указанный способ содержит стадию определения генотипа субъекта по одному или нескольким однонуклеотидным полиморфизмам (ОНП), стадию идентификации субъекта как прогнозируемо имеющего реакцию на глатирамера ацетат или не имеющего такой реакции, исходя из определенного генотипа по ОНП, и стадию введения субъекту фармацевтической композиции, содержащей глатирамера ацетат и фармацевтически приемлемый носитель только в случае, если субъект идентифицирован как прогнозируемо реагирующий на глатирамера ацетат.
EA201490749A 2011-10-10 2012-10-09 Однонуклеотидные полиморфизмы, полезные для прогнозирования клинической реакции на глатирамера ацетат EA201490749A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161545282P 2011-10-10 2011-10-10
US201261636560P 2012-04-20 2012-04-20
PCT/US2012/059352 WO2013055683A1 (en) 2011-10-10 2012-10-09 Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate

Publications (1)

Publication Number Publication Date
EA201490749A1 true EA201490749A1 (ru) 2014-09-30

Family

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Application Number Title Priority Date Filing Date
EA201490749A EA201490749A1 (ru) 2011-10-10 2012-10-09 Однонуклеотидные полиморфизмы, полезные для прогнозирования клинической реакции на глатирамера ацетат

Country Status (17)

Country Link
US (2) US8815511B2 (ru)
EP (1) EP2765857A4 (ru)
JP (1) JP2014530819A (ru)
KR (1) KR20140101730A (ru)
CN (1) CN103957705A (ru)
AR (1) AR088294A1 (ru)
AU (1) AU2012323345A1 (ru)
BR (1) BR112014008752A2 (ru)
CA (1) CA2851510A1 (ru)
EA (1) EA201490749A1 (ru)
HK (1) HK1200274A1 (ru)
IL (1) IL231723A0 (ru)
MX (1) MX2014004309A (ru)
TW (1) TW201326399A (ru)
UY (1) UY34380A (ru)
WO (1) WO2013055683A1 (ru)
ZA (1) ZA201403049B (ru)

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Publication number Publication date
BR112014008752A2 (pt) 2017-04-25
AR088294A1 (es) 2014-05-21
US20130123189A1 (en) 2013-05-16
UY34380A (es) 2013-05-31
US20150045306A1 (en) 2015-02-12
EP2765857A4 (en) 2015-12-09
ZA201403049B (en) 2015-09-30
NZ624258A (en) 2016-09-30
US9499868B2 (en) 2016-11-22
EP2765857A1 (en) 2014-08-20
CN103957705A (zh) 2014-07-30
IL231723A0 (en) 2014-05-28
KR20140101730A (ko) 2014-08-20
US8815511B2 (en) 2014-08-26
WO2013055683A1 (en) 2013-04-18
AU2012323345A1 (en) 2014-05-22
TW201326399A (zh) 2013-07-01
CA2851510A1 (en) 2013-04-18
HK1200274A1 (en) 2015-08-07
JP2014530819A (ja) 2014-11-20
MX2014004309A (es) 2015-07-06

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