UY35790A - Marcadores genéticos que predicen la respuesta al acetato de glatiramer - Google Patents

Marcadores genéticos que predicen la respuesta al acetato de glatiramer

Info

Publication number
UY35790A
UY35790A UY0001035790A UY35790A UY35790A UY 35790 A UY35790 A UY 35790A UY 0001035790 A UY0001035790 A UY 0001035790A UY 35790 A UY35790 A UY 35790A UY 35790 A UY35790 A UY 35790A
Authority
UY
Uruguay
Prior art keywords
location
glatiramer acetate
subject
group
alleles
Prior art date
Application number
UY0001035790A
Other languages
English (en)
Inventor
Tchelet Amir
Hayden Michael
Colin James Douglas Ross
Grossman Iris
Hayardeny Liat
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of UY35790A publication Critical patent/UY35790A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

La presente invención provee un método para el tratamiento de un sujeto humano afectado por esclerosis múltiple o de un ataque clínico único compatible con la esclerosis múltiple con una composición farmacéutica que comprende acetato de glatiramer y un vehículo farmacéuticamente aceptable, que comprende los pasos de:(i) determinar un genotipo del sujeto en una ubicación correspondiente a la ubicación de uno o más polimorfismos de nucleótido simple (SNP) seleccionados del grupo formado por: Grupo 1, (ii) identificar al sujeto como un respondedor predicho al acetato de glatiramer si el genotipo del sujeto contiene uno o más alelos A en la ubic ación de Grupo 2, uno o más alelos C en la ubicación de Grupo 3, uno o más alelos G en la ubicación de Grupo 4, o uno o más alelos T en la ubicación de kgp18432055, kgp279772, kgp3991733 o kgp7242489; y administrar la composición farmacéutica que comprende acetato de glatiramer y un vehículo farmacéuticamente aceptable al sujeto solamente si el sujeto está identificado como un respondedor predicho al acetato de glatiramer
UY0001035790A 2013-10-21 2014-10-20 Marcadores genéticos que predicen la respuesta al acetato de glatiramer UY35790A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361893807P 2013-10-21 2013-10-21
US201462048127P 2014-09-09 2014-09-09
US201462048641P 2014-09-10 2014-09-10

Publications (1)

Publication Number Publication Date
UY35790A true UY35790A (es) 2015-05-29

Family

ID=52826364

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035790A UY35790A (es) 2013-10-21 2014-10-20 Marcadores genéticos que predicen la respuesta al acetato de glatiramer

Country Status (13)

Country Link
US (2) US9702007B2 (es)
EP (1) EP3060681A4 (es)
JP (1) JP2016540729A (es)
KR (1) KR20160098199A (es)
CN (1) CN105658818A (es)
AU (1) AU2014340247A1 (es)
CA (1) CA2926724A1 (es)
EA (1) EA201690759A1 (es)
IL (1) IL244783A0 (es)
MX (1) MX2016005003A (es)
TW (1) TW201610166A (es)
UY (1) UY35790A (es)
WO (1) WO2015061367A1 (es)

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US9155775B1 (en) 2015-01-28 2015-10-13 Teva Pharmaceutical Industries, Ltd. Process for manufacturing glatiramer acetate product
CA3050086A1 (en) 2017-03-26 2018-10-04 Mapi Pharma Ltd. Glatiramer depot systems for treating progressive forms of multiple sclerosis
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CN111088368B (zh) * 2019-12-30 2021-04-16 山西医科大学 一种血液mRNA检测试剂盒及检测方法

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Also Published As

Publication number Publication date
EA201690759A1 (ru) 2017-01-30
TW201610166A (zh) 2016-03-16
EP3060681A4 (en) 2017-06-07
EP3060681A1 (en) 2016-08-31
AU2014340247A1 (en) 2016-06-02
MX2016005003A (es) 2016-08-03
US20150110733A1 (en) 2015-04-23
WO2015061367A1 (en) 2015-04-30
US9702007B2 (en) 2017-07-11
CA2926724A1 (en) 2015-04-30
KR20160098199A (ko) 2016-08-18
US20180002753A1 (en) 2018-01-04
CN105658818A (zh) 2016-06-08
JP2016540729A (ja) 2016-12-28
IL244783A0 (en) 2016-04-21

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