AR088294A1 - Determinacion de polimorfismos de un nucleotido simple utiles para predecir la respuesta clinica al acetato de glatiramero - Google Patents
Determinacion de polimorfismos de un nucleotido simple utiles para predecir la respuesta clinica al acetato de glatirameroInfo
- Publication number
- AR088294A1 AR088294A1 ARP120103778A ARP120103778A AR088294A1 AR 088294 A1 AR088294 A1 AR 088294A1 AR P120103778 A ARP120103778 A AR P120103778A AR P120103778 A ARP120103778 A AR P120103778A AR 088294 A1 AR088294 A1 AR 088294A1
- Authority
- AR
- Argentina
- Prior art keywords
- subject
- acetate
- glatiramer acetate
- polymorphysms
- glatiramero
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Provee un método para tratar a un sujeto humano afectado por esclerosis múltiple o un ataque clínico único consistente con esclerosis múltiple con una composición farmacéutica que comprende acetato de glatirámero y un vehículo farmacéuticamente aceptable, que comprende los pasos de: i) determinar un genotipo del sujeto en uno o más polimorfismos de nucleótido simple (SNP) que se eligen del grupo que consiste en: rs1007328, rs10083547, rs10136012, rs10214633, rs10277267, rs1040194, rs1041897, rs10853605, rs10931091, rs10935015, rs10935016, rs10935019, rs10950359, rs10950371, rs10988087, rs11009827, rs11009835, rs11081859, rs11599624, rs11617134, rs11618546, rs11694344, rs11709339, rs11719825, rs11761457, rs11907046, rs12055694, rs12256889, rs1229542, rs1229553, rs1229555, rs1229558, rs1229562, rs1229563, rs1229564, rs1229568, rs12340584, rs1234567, rs1234947, rs1237625, rs12488259, rs12494606, rs12496278, rs12524041, rs12529764, rs12532459, rs12540494, rs12593600, rs12633010, rs12637073, rs12639443, rs1264423, rs1282540, rs1282546, rs12968586, rs1299325, rs13021482, rs13042992, rs1320648, rs13238613, rs13245980, rs1415557, rs1538123, rs1573706, rs1591661, rs1611185, rs1683691, rs16999008, rs17007730, rs17087180, rs17104665, rs17104742, rs17134651, rs17575455, rs17588454, rs17666347, rs17771939, rs17807327, rs17807445, rs1886308, rs1892974, rs1941973, rs2033471, rs2088713, rs214526, rs2155262, rs2177073, rs2187495, rs2277431, rs2305623, rs2374730, rs2461319, rs2487889, rs2487896, rs2508806, rs2511064, rs2521643, rs2521644, rs2530121, rs2530123, rs2685484, rs2722396, rs2722398, rs28861531, rs2895215, rs2937395, rs3135391, rs35831078, rs3742228, rs401618, rs4148871, rs4255033, rs4281882, rs4289164, rs4306478, rs4343256, rs4344916, rs4369324, rs4435429, rs4445746, rs4466940, rs4468448, rs4483642, rs4565951, rs4578835, rs4634524, rs4799760, rs4809955, rs4811492, rs496486, rs552994, rs6015147, rs6025923, rs6025927, rs609 1820, rs6097782, rs6097790, rs6097793, rs6097797, rs6097801, rs6123749, rs6543934, rs6558102, rs656975, rs657302, rs6584894, rs660075, rs6713772, rs6909321, rs6971202, rs702355, rs7080507, rs7086707, rs7093143, rs7178587, rs7180867, rs7232734, rs7238006, rs7244801, rs7317000, rs751370, rs752979,rs7619350,rs7633210, rs7714122, rs7789703, rs7803164, rs7806265, rs7916897, rs7955917, rs7963693, rs8099595, rs8118441; rs844602, rs844608, rs844610, rs844612, rs844626, rs860722, rs873216, rs884266, rs894857, rs913882, rs9315048, rs9332420, rs933863, rs933864. rs9378319, rs9378684, rs9392358, rs9405541, rs9405546, rs947603, rs948029, rs948032, rs949298, rs9508834, rs9944913, rs9952995, y rs998051; ii) identificar al sujeto como un respordedor predicho al acetato de glatirámero si el genotipo es AA en rs10214633, rs10277267, rs10935015, rs10935019, rs10988087, rs11081859, rs11694344, rs12256889, rs12340584, rs12494606, rs1415557, rs17007730, rs17087180, rs17104665, rs17104742, rs17588454, rs17807327, rs1892974, rs2088713, rs214526, rs2374730, rs4255033, rs4306478, rs4343256, rs43449 16, rs4435429, rs4578835, rs4809955, rs496486, rs6015147, rs6097790, rs6584894, rs6713772, rs6909321, rs702355, rs7086707, rs7180867, rs7317000, rs844608, rs844610, rs933863, rs9392358, rs948029, o rs9508834, AT en rs12524041 o rs7806265, AG en rs10277267, rs10950359, rs11599624, rs13245980, rs1415557, rs2521643, rs4255033, rs6584894, rs6909321, rs702355, o rs844626, AC en rs12256889, rs1229542, rs214526, rs6097793, rs7086707, rs7180867, rs844608, o rs844610, TT en rs1007328, rs10931091, rs11617134, rs11709339, rs11719825, rs11761457, rs1229553, rs1234567, rs1234947, rs12532459, rs12593600, rs1264423, rs13042992, rs1320648, rs1538123, rs1591661, rs17134651, rs17666347, rs17771939, rs2461319, rs2508806, rs2722396, rs2722398, rs2895215, rs401618, rs4369324, rs4483642, rs4565951, rs4811492, rs552994, rs6025923, rs6025927, rs6097797, rs657302, rs7232734, rs751 370, rs7633210, rs7714122, rs7803164, rs7806265, rs7916897, rs8118441, rs844612, rs9378319, o rs9952995, GT en rs12532459, rs2722398, rs4369324, o rs7093143, CT en rs10950371, rs11761457, rs1229562, rs12529764, rs13021482, rs13238613, rs1538123, rs1591661, rs1611185, rs17807445, rs1941973, rs2461 319, rs2685484, rs28952151, rs4634524, rs4799760, rs6097797, rs7080507, rs7238006, rs7789703, rs78031641, rs844612, o rs947603, GG en rs10083547, rs10136012, rs10950359, rs11599624, rs12055694, rs1229558, rs1237625, rs12496278, rs12540494, rs12633010, rs12637073, rs1282540, rs1282546, rs12968586, rs1299325, rs13245980, rs16999008, rs17104665, rs17104742, rs2033471, rs2155262, rs2487889, rs2487896, rs2511064, rs2521643, rs2530121, rs2530123, rs28861531, rs3135391, rs4148871, rs4289164, rs4445746, rs6097801, rs6543934, rs6558102, rs656975, rs6971202, rs7093143, rs7244801, rs752979, rs7619350, rs7955917, rs844626, rs873216, rs894857, rs9315048, rs9332420, rs933864, rs948032, rs949298, o rs998051, CG en rs11618546 o rs860722, o CC en rs1041897, rs10853605, rs10935016, rs10950371, rs11009827, rs11009835, rs11618546, rs11907046, rs1229542, rs1229555, rs1229562, rs1229563, rs1229564, rs1229568, rs12488259, rs12639443, rs13021482, rs13238613, rs1573706, rs1683691, rs17575455, rs17807445, rs2177073, rs2187495, rs2277431, rs2521644, rs2685484, rs2937395, rs4281882, rs4466940, rs4468448, rs4634524, rs4799760, rs6091820, rs6097782; rs6097793, rs6123749, rs660075, rs7080507, rs7789703, rs7963693, rs8099595 rs544602, rs860722, rs884266, rs913882, rs9378684, rs9405541, rs9405546, rs947603, o rs9944913; y iii) administrar la composición farmacéutica que comprende acetato de glatirámero y un vehículo farmacéuticamente aceptable al sujeto sólo si el sujeto se identifica como un respondedor predicho al acetato de glatirámero. Reivindicación 1: Una sonda para identificar el genotipo de un SNP que se elige del grupo que consiste en rs1007328, rs10083547, rs10136012, rs10214633, rs10277267, rs1040194, rs1041897, rs10853605, rs10931091, rs10935015, rs10935016, rs10935019, rs10950359, rs10950371, rs10988087, rs11009827, rs11009835, rs11081859, rs11599624, rs11617134, rs11618546, rs11694344, rs11709339, rs11719825, rs11761457, rs11907046, rs12055694, rs12256889, rs1229542, rs1229553, rs1229555, rs1229558, rs1229562, rs1229563, rs1229564, rs1229568, rs12340584, rs1234567, rs1234947, rs1237625, rs12488259, rs12494606, rs12496278, rs12524041, rs12529764, rs12532459, rs12540494, rs12593600, rs12633010, rs12637073, rs12639443, rs1264423, rs1282540, rs1282546, rs12968586, rs1299325, rs13021482, rs13042992, rs1320648, rs13238613, rs13245980, rs1415557, rs1538123, rs1573706, rs1591661, rs1611185, rs1683691, rs16999008, rs17007730, rs17087180, rs17104665, rs17104742, rs17134651, rs17575455, rs17588454, rs17666347, rs17771939, rs17807327, rs17807445, rs1886308, rs1892974, rs1941973, rs2033471, rs2088713, rs214526, rs2155262, rs2177073, rs2187495, rs2277431, rs2305623, rs2374730, rs2461319, rs2487889, rs2487896, rs2508806, rs2511064, rs2521643, rs2521644, rs2530121, rs2530123, rs2685484, rs2722396, rs2722398, rs28861531, rs2895215, rs2937395, rs3135391, rs35831078, rs3742228, rs401618, rs4148871, rs4255033, rs4281882, rs4289164, rs4306478, rs4343256, rs4344916, rs4369324, rs4435429, rs4445746, rs4466940, rs4468448, rs4483642, rs4565951, rs4578835, rs4634524, rs4799760, rs4809955, rs4811492, rs496486, rs552994, rs6015147, rs6025923, rs6025927, rs6091820, rs6097782, rs6097790, rs6097793, rs6097797, rs6097801, rs6123749, rs6543934, rs6558102, rs656975, rs657302, rs6584894, rs660075, rs6713772, rs6909321, rs6971202, rs702355, rs7080507, rs7086707, rs7093143, rs7178587, rs7180867, rs7232734, rs7238006, rs7244801, rs7317000, rs751370, rs752979, rs7619350, rs7633210, rs7714122, rs7789703, rs7803164, rs7806265, rs7916897, rs7955917, rs7963693, rs8099595, rs8118441, rs844602, rs844608, rs844610, rs844612, rs844626, rs860722, rs873216, rs884266, rs894857, rs913882, rs9315048, rs9332420, rs933863, rs933864, rs9378319, rs9378684, rs9392358, rs9405541, rs9405546, rs947603, rs948029, rs948032, rs949298, rs9508834, rs9944913, rs9952995, y rs998051.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545282P | 2011-10-10 | 2011-10-10 | |
| US201261636560P | 2012-04-20 | 2012-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088294A1 true AR088294A1 (es) | 2014-05-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120103778A AR088294A1 (es) | 2011-10-10 | 2012-10-10 | Determinacion de polimorfismos de un nucleotido simple utiles para predecir la respuesta clinica al acetato de glatiramero |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8815511B2 (es) |
| EP (1) | EP2765857A4 (es) |
| JP (1) | JP2014530819A (es) |
| KR (1) | KR20140101730A (es) |
| CN (1) | CN103957705A (es) |
| AR (1) | AR088294A1 (es) |
| AU (1) | AU2012323345A1 (es) |
| BR (1) | BR112014008752A2 (es) |
| CA (1) | CA2851510A1 (es) |
| EA (1) | EA201490749A1 (es) |
| HK (1) | HK1200274A1 (es) |
| IL (1) | IL231723A0 (es) |
| MX (1) | MX2014004309A (es) |
| TW (1) | TW201326399A (es) |
| UY (1) | UY34380A (es) |
| WO (1) | WO2013055683A1 (es) |
| ZA (1) | ZA201403049B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8399413B2 (en) | 2009-08-20 | 2013-03-19 | Yeda Research & Development Co., Ltd. | Low frequency glatiramer acetate therapy |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| WO2012051106A1 (en) | 2010-10-11 | 2012-04-19 | Teva Pharmaceutical Industries Ltd. | Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate |
| MX2014004309A (es) | 2011-10-10 | 2015-07-06 | Teva Pharma | Polimorfismos de nucleotidos individuales utiles para predecir una respuesta clinica para el acetato de glatiramer. |
| TW201420111A (zh) | 2012-10-10 | 2014-06-01 | Teva Pharma | 對格拉默醋酸鹽（ｇｌａｔｉｒａｍｅｒ ａｃｅｔａｔｅ）之臨床反應具預測性之生物標記 |
| UY35790A (es) * | 2013-10-21 | 2015-05-29 | Teva Pharma | Marcadores genéticos que predicen la respuesta al acetato de glatiramer |
| US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
| WO2016172124A1 (en) * | 2015-04-21 | 2016-10-27 | Teva Pharmaceutical Industries Ltd. | Select single nucleotide polymorphisms predictive of response to glatiramer acetate |
| EP3600553A4 (en) | 2017-03-26 | 2020-09-02 | Mapi Pharma Ltd. | GLATIRAMER DEPOT SYSTEMS FOR TREATMENT OF PROGRESSIVE FORMS OF MULTIPLE SCLEROSIS |
| US11396825B2 (en) * | 2017-08-14 | 2022-07-26 | General Electric Company | Turbine diagnostic feature selection system |
| WO2020092753A1 (en) * | 2018-11-01 | 2020-05-07 | I2Dx, Inc. | Intelligent system and methods for therapeutic target identification |
| WO2020237314A1 (en) * | 2019-05-30 | 2020-12-03 | The University Of Newcastle | A method of treatment or prophylaxis |
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-
2012
- 2012-10-09 MX MX2014004309A patent/MX2014004309A/es unknown
- 2012-10-09 KR KR1020147012550A patent/KR20140101730A/ko not_active Application Discontinuation
- 2012-10-09 CN CN201280058097.0A patent/CN103957705A/zh active Pending
- 2012-10-09 EA EA201490749A patent/EA201490749A1/ru unknown
- 2012-10-09 EP EP12840243.5A patent/EP2765857A4/en not_active Withdrawn
- 2012-10-09 BR BR112014008752A patent/BR112014008752A2/pt not_active IP Right Cessation
- 2012-10-09 AU AU2012323345A patent/AU2012323345A1/en not_active Abandoned
- 2012-10-09 JP JP2014535787A patent/JP2014530819A/ja not_active Withdrawn
- 2012-10-09 US US13/648,135 patent/US8815511B2/en not_active Expired - Fee Related
- 2012-10-09 CA CA2851510A patent/CA2851510A1/en not_active Abandoned
- 2012-10-09 WO PCT/US2012/059352 patent/WO2013055683A1/en active Application Filing
- 2012-10-09 TW TW101137349A patent/TW201326399A/zh unknown
- 2012-10-10 UY UY0001034380A patent/UY34380A/es not_active Application Discontinuation
- 2012-10-10 AR ARP120103778A patent/AR088294A1/es unknown
-
2014
- 2014-03-26 IL IL231723A patent/IL231723A0/en unknown
- 2014-04-25 ZA ZA2014/03049A patent/ZA201403049B/en unknown
- 2014-08-25 US US14/467,954 patent/US9499868B2/en not_active Expired - Fee Related
-
2015
- 2015-01-09 HK HK15100236.7A patent/HK1200274A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103957705A (zh) | 2014-07-30 |
| WO2013055683A1 (en) | 2013-04-18 |
| EP2765857A1 (en) | 2014-08-20 |
| TW201326399A (zh) | 2013-07-01 |
| UY34380A (es) | 2013-05-31 |
| HK1200274A1 (en) | 2015-08-07 |
| NZ624258A (en) | 2016-09-30 |
| MX2014004309A (es) | 2015-07-06 |
| ZA201403049B (en) | 2015-09-30 |
| IL231723A0 (en) | 2014-05-28 |
| EP2765857A4 (en) | 2015-12-09 |
| KR20140101730A (ko) | 2014-08-20 |
| CA2851510A1 (en) | 2013-04-18 |
| US20130123189A1 (en) | 2013-05-16 |
| AU2012323345A1 (en) | 2014-05-22 |
| BR112014008752A2 (pt) | 2017-04-25 |
| JP2014530819A (ja) | 2014-11-20 |
| US8815511B2 (en) | 2014-08-26 |
| US9499868B2 (en) | 2016-11-22 |
| EA201490749A1 (ru) | 2014-09-30 |
| US20150045306A1 (en) | 2015-02-12 |
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