BR112019028280A2 - moléculas de ácido nucleico - Google Patents
moléculas de ácido nucleico Download PDFInfo
- Publication number
- BR112019028280A2 BR112019028280A2 BR112019028280-7A BR112019028280A BR112019028280A2 BR 112019028280 A2 BR112019028280 A2 BR 112019028280A2 BR 112019028280 A BR112019028280 A BR 112019028280A BR 112019028280 A2 BR112019028280 A2 BR 112019028280A2
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- nucleic acid
- rna
- subunit
- sequence
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y503/00—Intramolecular oxidoreductases (5.3)
- C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
- C12Y503/03012—L-Dopachrome isomerase (5.3.3.12)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/605—MHC molecules or ligands thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2017/066676 | 2017-07-04 | ||
| EPPCT/EP2017/066676 | 2017-07-04 | ||
| PCT/EP2018/068015 WO2019008001A1 (en) | 2017-07-04 | 2018-07-03 | NEW NUCLEIC ACID MOLECULES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019028280A2 true BR112019028280A2 (pt) | 2020-07-14 |
Family
ID=59384128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019028280-7A BR112019028280A2 (pt) | 2017-07-04 | 2018-07-03 | moléculas de ácido nucleico |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10988754B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP3648791A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7722629B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102761594B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN111328287A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2018298422B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112019028280A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3066932A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES3013993T3 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2020103379A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201911430PA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2019008001A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (179)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
| SMT202200355T1 (it) * | 2011-12-16 | 2022-11-18 | Modernatx Inc | Composizioni di mrna modificato |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| MX2019002345A (es) | 2012-03-27 | 2022-08-24 | Curevac Ag | Moleculas artificiales de acido nucleico para la expresion mejorada de proteina o peptido. |
| MX385338B (es) | 2013-02-22 | 2025-03-18 | CureVac SE | Combinación de vacunación e inhibición de la trayectoria pd-1. |
| ES2747762T3 (es) | 2013-08-21 | 2020-03-11 | Curevac Ag | Vacuna contra el virus respiratorio sincitial (RSV) |
| WO2015024669A1 (en) | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Combination vaccine |
| WO2015024665A1 (en) | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Rabies vaccine |
| ES2754239T3 (es) | 2014-03-12 | 2020-04-16 | Curevac Ag | Combinación de vacunación y agonistas de OX40 |
| DK3708668T3 (da) | 2014-12-12 | 2022-09-26 | Curevac Ag | Kunstigt nukleinsyremolekyle til forbedret proteinudtrykkelse |
| EP4461371A3 (en) | 2014-12-23 | 2025-02-26 | immatics biotechnologies GmbH | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (hcc) and other cancers |
| GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| EP3294885B1 (en) | 2015-05-08 | 2020-07-01 | CureVac Real Estate GmbH | Method for producing rna |
| DE202016009003U1 (de) | 2015-05-29 | 2021-05-28 | Curevac Real Estate Gmbh | Zusammensetzung umfassend in vitro transkribierte RNA erhältlich durch ein Verfahren zur Herstellung und Reinigung von RNA mit mindestens einem Schritt mit einer tangentialen Flussfiltration |
| GB201513921D0 (en) * | 2015-08-05 | 2015-09-23 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers |
| EP3362576A1 (en) | 2015-10-12 | 2018-08-22 | CureVac AG | Automated method for isolation, selection and/or detection of microorganisms or cells comprised in a solution |
| US11413346B2 (en) | 2015-11-09 | 2022-08-16 | Curevac Ag | Rotavirus vaccines |
| IL298653A (en) | 2015-12-11 | 2023-01-01 | Immatics Biotechnologies Gmbh | New peptides and a combination of peptides for use in immunotherapy against several types of cancer |
| US11684665B2 (en) | 2015-12-22 | 2023-06-27 | CureVac SE | Method for producing RNA molecule compositions |
| US11248223B2 (en) | 2015-12-23 | 2022-02-15 | Curevac Ag | Method of RNA in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof |
| WO2017140905A1 (en) | 2016-02-17 | 2017-08-24 | Curevac Ag | Zika virus vaccine |
| WO2017149139A1 (en) | 2016-03-03 | 2017-09-08 | Curevac Ag | Rna analysis by total hydrolysis |
| GB201604458D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against cancers |
| GB201604490D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides combination of peptides for use in immunotherapy against cancers |
| EP3448427A1 (en) | 2016-04-29 | 2019-03-06 | CureVac AG | Rna encoding an antibody |
| US11141474B2 (en) | 2016-05-04 | 2021-10-12 | Curevac Ag | Artificial nucleic acid molecules encoding a norovirus antigen and uses thereof |
| EP3452101A2 (en) | 2016-05-04 | 2019-03-13 | CureVac AG | Rna encoding a therapeutic protein |
| BR112018075479A2 (pt) | 2016-06-09 | 2019-03-19 | Curevac Ag | portadores híbridos para carga de ácido nucleico |
| US11279923B2 (en) | 2016-11-28 | 2022-03-22 | Curevac Ag | Method for purifying RNA |
| WO2018104538A1 (en) | 2016-12-08 | 2018-06-14 | Curevac Ag | Rna for treatment or prophylaxis of a liver disease |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| WO2018104540A1 (en) | 2016-12-08 | 2018-06-14 | Curevac Ag | Rnas for wound healing |
| EP3558355A2 (en) | 2016-12-23 | 2019-10-30 | CureVac AG | Henipavirus vaccine |
| EP3558356A2 (en) | 2016-12-23 | 2019-10-30 | CureVac AG | Mers coronavirus vaccine |
| WO2018115525A1 (en) | 2016-12-23 | 2018-06-28 | Curevac Ag | Lassa virus vaccine |
| JP2020513824A (ja) | 2017-03-24 | 2020-05-21 | キュアバック アーゲー | Crispr関連タンパク質をコードする核酸、及びその使用 |
| US11357856B2 (en) | 2017-04-13 | 2022-06-14 | Acuitas Therapeutics, Inc. | Lipids for delivery of active agents |
| CN108728477B (zh) * | 2017-04-24 | 2022-02-22 | 华东理工大学 | 一种高效的转座突变系统及构建方法 |
| WO2018211038A1 (en) | 2017-05-17 | 2018-11-22 | Curevac Ag | Method for determining at least one quality parameter of an rna sample |
| WO2019005822A1 (en) | 2017-06-28 | 2019-01-03 | The Cleveland Clinic Foundation | TREATMENT OF AN INJURY OF THE NERVOUS SYSTEM AND NEURODEGENERATIVE DISORDERS AND ASSOCIATED DISORDERS |
| JP2020530759A (ja) | 2017-07-07 | 2020-10-29 | イマティクス バイオテクノロジーズ ゲーエムベーハー | Nsclc、sclc、およびその他のがんをはじめとする肺がんに対する免疫療法で使用するための新規ペプチドおよびペプチド併用 |
| EP3673069A1 (en) | 2017-08-22 | 2020-07-01 | CureVac AG | Bunyavirales vaccine |
| JP2021502079A (ja) | 2017-11-08 | 2021-01-28 | キュアバック アーゲー | RNA配列の適合(Adaptation) |
| EP3723796A1 (en) | 2017-12-13 | 2020-10-21 | CureVac AG | Flavivirus vaccine |
| CN111511928A (zh) | 2017-12-21 | 2020-08-07 | 库瑞瓦格股份公司 | 偶联到单一支持物或标签的线性双链dna和用于制备所述线性双链dna的方法 |
| DE202019006108U1 (de) | 2018-04-17 | 2024-12-16 | CureVac SE | Neue RSV-RNA-Moleküle und Zusammensetzungen für die Impfung |
| EP3814495B1 (en) | 2018-06-28 | 2023-06-07 | CureVac RNA Printer GmbH | Bioreactor for rna in vitro transcription |
| US10925947B2 (en) | 2018-06-29 | 2021-02-23 | Immatics Biotechnologies Gmbh | A*03 restricted peptides for use in immunotherapy against cancers and related methods |
| TW202024121A (zh) | 2018-09-18 | 2020-07-01 | 德商英麥提克生物技術股份有限公司 | A*01 限制肽和肽組合物在抗癌免疫治療中的用途和相關方法 |
| TW202039534A (zh) * | 2018-12-14 | 2020-11-01 | 美商美國禮來大藥廠 | KRAS變體mRNA分子 |
| WO2020127959A1 (en) | 2018-12-21 | 2020-06-25 | Curevac Ag | Methods for rna analysis |
| EP3683229A1 (en) * | 2019-01-21 | 2020-07-22 | Charité - Universitätsmedizin Berlin | Specific t cell receptors against epitopes of mutant myd88l265p protein for adoptive t cell therapy |
| CN111466338B (zh) * | 2019-01-23 | 2022-03-22 | 中国科学院广州生物医药与健康研究院 | Ddx5基因缺失的生精障碍小鼠模型及其构建方法 |
| US20220177891A1 (en) * | 2019-02-19 | 2022-06-09 | Board Of Regents, The University Of Texas System | Hipk inhibitors and methods of use thereof |
| CN109777783B (zh) * | 2019-02-20 | 2023-07-04 | 上海尚泰生物技术有限公司 | 表达cxcr2的car-nk92细胞、制备方法及其应用 |
| CN111620934B (zh) * | 2019-02-26 | 2022-03-08 | 中国科学院遗传与发育生物学研究所 | 蛋白GmHSFB2b在调控植物黄酮类化合物积累中应用 |
| CN110093419B (zh) * | 2019-04-26 | 2023-10-27 | 北京大学深圳医院 | 环状rna的应用、试剂盒和药物组合物及其应用 |
| CN114072175A (zh) * | 2019-07-04 | 2022-02-18 | 江苏康宁杰瑞生物制药有限公司 | 治疗肿瘤的物质和方法 |
| CN112175062B (zh) * | 2019-07-05 | 2022-07-15 | 中国医学科学院基础医学研究所 | Sft2b蛋白线性抗原表位以及其在精神分裂症诊断中的用途 |
| WO2021041541A1 (en) * | 2019-08-28 | 2021-03-04 | The Board Of Trustees Of The Leland Stanford Junior University | Modified circular rnas and methods of use thereof |
| WO2021081058A1 (en) * | 2019-10-21 | 2021-04-29 | Translate Bio, Inc. | Compositions, methods and uses of messenger rna |
| KR20220113485A (ko) * | 2019-12-11 | 2022-08-12 | 아벨리노 랩 유에스에이, 인크. | 짧은 간섭 rna를 사용한 r124h 돌연변이에 의한 형질전환 성장 인자 베타 유도된 유전자의 대립유전자-특이적 사일런싱 |
| CN111057690A (zh) * | 2019-12-23 | 2020-04-24 | 维塔恩(广州)医药有限公司 | 肿瘤相关基因braf突变相关抗原短肽及其应用 |
| US12194089B2 (en) | 2020-02-04 | 2025-01-14 | CureVac SE | Coronavirus vaccine |
| US11241493B2 (en) | 2020-02-04 | 2022-02-08 | Curevac Ag | Coronavirus vaccine |
| CN111647598B (zh) * | 2020-02-11 | 2022-09-06 | 昆明医科大学 | 一种抑制hsa_circ_0027477表达的siRNA及其应用 |
| CN111118011B (zh) * | 2020-02-11 | 2022-09-06 | 昆明医科大学 | 一种抑制hsa_circ_0027478表达的siRNA及其应用 |
| CN111733158B (zh) * | 2020-02-11 | 2022-09-06 | 昆明医科大学 | 一种抑制hsa_circ_0003599表达的siRNA及其应用 |
| CN111647597B (zh) * | 2020-02-11 | 2022-09-06 | 昆明医科大学 | 一种抑制hsa_circ_0027479表达的siRNA及其应用 |
| CN111337678B (zh) * | 2020-02-21 | 2023-06-06 | 杭州凯保罗生物科技有限公司 | 与肿瘤免疫治疗效果相关的生物标志物及其应用 |
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| EP4175967A2 (en) | 2020-07-02 | 2023-05-10 | Life Technologies Corporation | Trinucleotide cap analogs, preparation and uses thereof |
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| CN116635525A (zh) * | 2020-08-21 | 2023-08-22 | 北京大学 | 环状rna疫苗及其使用方法 |
| CN112011564A (zh) * | 2020-09-04 | 2020-12-01 | 西南大学 | 新型隐球菌细胞核指示载体及其构建方法和应用 |
| CN111973745B (zh) * | 2020-09-08 | 2022-07-26 | 中国医科大学 | Bap18在乳腺癌内分泌治疗抵抗中的应用 |
| CN114225035B (zh) * | 2020-09-09 | 2022-12-16 | 上海交通大学医学院 | 环状RNA Cwc27下调剂在制备预防和/或治疗阿尔茨海默病的药物中的应用 |
| DE102020125457A1 (de) * | 2020-09-29 | 2022-03-31 | Immatics Biotechnologies Gmbh | Amidierte Peptide und ihre deamidierten Gegenstücke, die durch HLA-A*02-Moleküle präsentiert werden, zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
| CN112574975B (zh) * | 2020-09-30 | 2022-04-01 | 华南理工大学 | 甘油酯脂肪酶突变体g28c-p206c及其编码基因与应用 |
| CN112050201B (zh) * | 2020-10-10 | 2022-04-12 | 清华大学 | 一种异型炉膛结构的湍动流化床焚烧炉 |
| CN112190719B (zh) * | 2020-10-19 | 2023-07-04 | 重庆大学 | 一种钙调控机制紊乱的动物模型在视网膜病变中的应用 |
| CN112375766B (zh) * | 2020-12-02 | 2022-04-29 | 华南农业大学 | 一种水稻抗氧化能力相关基因brhis1及其应用 |
| CN112480232B (zh) * | 2020-12-14 | 2022-07-15 | 上海交通大学 | 一种生物活性肽vsladlqndevafr及其制备方法和应用 |
| CN112961247A (zh) * | 2020-12-17 | 2021-06-15 | 维亚生物科技(上海)有限公司 | 一种融合蛋白及其应用 |
| CN112575003B (zh) * | 2020-12-17 | 2022-02-15 | 中国农业科学院植物保护研究所 | 本氏烟hakai基因在调控植物抗病毒中的应用及转基因植物培育方法 |
| US11918643B2 (en) | 2020-12-22 | 2024-03-05 | CureVac SE | RNA vaccine against SARS-CoV-2 variants |
| CN112630449B (zh) * | 2020-12-30 | 2022-10-18 | 广西壮族自治区水牛研究所 | 对水牛出生时间进行判断的血液外泌体标志物及其应用 |
| CN112662680B (zh) * | 2020-12-31 | 2022-07-05 | 浙江大学 | 番茄黄化转绿基因SlRHBDD2及其应用 |
| CN112763714B (zh) * | 2020-12-31 | 2022-07-01 | 徐州市中心医院 | 一种用于肝癌诊断的生物标志物及其检测方法 |
| CN112794901B (zh) * | 2021-01-08 | 2022-01-04 | 南通大学附属医院 | 一种抗smim15单克隆抗体及其应用 |
| CN112362432B (zh) * | 2021-01-12 | 2021-04-09 | 广州科方生物技术股份有限公司 | 一种通用于血清中tt3和tt4的解离剂及其制备方法 |
| CN114762694B (zh) * | 2021-01-13 | 2023-07-14 | 中国人民解放军军事科学院军事医学研究院 | 寡糖转移酶抑制剂在预防和/或治疗新型冠状病毒感染中的应用 |
| CN112626236A (zh) * | 2021-01-14 | 2021-04-09 | 华南农业大学 | 与奶牛乳腺上皮细胞凋亡相关的circRNA标志物及其应用 |
| CN112679596B (zh) * | 2021-01-15 | 2022-03-15 | 武汉大学 | 一种内收蛋白的抗原肽及其抗体与应用 |
| CN112574997B (zh) * | 2021-01-17 | 2023-07-21 | 楷拓生物科技(苏州)有限公司 | 一种fbxw7环状rna的改构体及其在肿瘤药物和新冠疫苗中的应用 |
| CN112852698B (zh) * | 2021-01-30 | 2022-11-29 | 军事科学院军事医学研究院军事兽医研究所 | 牛种布鲁氏菌A19株asd基因缺失株的构建方法和应用 |
| CN112795642A (zh) * | 2021-02-09 | 2021-05-14 | 四川大学华西医院 | 鉴定家族性渗出性玻璃体视网膜病变伴/不伴小头畸形的引物及其应用 |
| WO2022173730A1 (en) * | 2021-02-09 | 2022-08-18 | Virginia Commonwealth University | Mini circular rna therapeutics and vaccines and methods of use thereof |
| US20220372165A1 (en) | 2021-05-05 | 2022-11-24 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
| CN113373129B (zh) * | 2021-05-25 | 2022-07-26 | 湖北大学 | 一种原核生物来源的Mbp_Argonaute蛋白及其应用 |
| CN113393900B (zh) * | 2021-06-09 | 2022-08-02 | 吉林大学 | 基于改进Transformer模型的RNA状态推断研究方法 |
| CN115491369B (zh) * | 2021-06-18 | 2025-06-03 | 佛山热休生物技术有限公司 | Pdia3的表位肽及所述表位肽与热休克蛋白的复合物 |
| CN113450872B (zh) * | 2021-07-02 | 2022-12-02 | 南昌大学 | 磷酸化位点特异激酶的预测方法 |
| CN113687076B (zh) * | 2021-07-14 | 2024-03-01 | 郑州大学 | 一种可用于肺腺癌早期诊断的联合检测血清标志物及其应用 |
| CN117980322A (zh) * | 2021-07-23 | 2024-05-03 | 卡萨瓦科学公司 | 用于阿尔茨海默病的基于血液的诊断测定 |
| WO2023014598A2 (en) * | 2021-08-03 | 2023-02-09 | Inflammatix, Inc. | Isothermal amplification-based diagnosis and treatment of acute infection |
| CN113846122B (zh) * | 2021-08-16 | 2023-08-25 | 中国医学科学院医学生物学研究所 | 一种过表达snca的腺相关病毒载体aav-snca、制备方法及其应用 |
| AU2021461416A1 (en) | 2021-08-24 | 2024-02-22 | BioNTech SE | In vitro transcription technologies |
| CN113533589B (zh) * | 2021-09-16 | 2021-12-17 | 天九再生医学(天津)科技有限公司 | 一种分析外泌体电荷异质性的方法 |
| CN114457052B (zh) * | 2021-09-17 | 2024-02-27 | 厦门大学 | 一种抗肿瘤的多肽组合物及其应用 |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| CA3238757A1 (en) | 2021-11-29 | 2023-06-01 | Alexander Muik | Coronavirus vaccine |
| CN114134109B (zh) * | 2021-12-10 | 2023-01-24 | 广州远想生物科技股份有限公司 | Egf间充质干细胞外泌体的纯化方法 |
| KR102818855B1 (ko) * | 2021-12-13 | 2025-06-16 | 주식회사 에스엠엘바이오팜 | 발현 효율을 증가시킨 핵산 발현 플랫폼 |
| CN114262378B (zh) * | 2021-12-20 | 2023-03-24 | 南京诺唯赞生物科技股份有限公司 | 一种omt的单克隆抗体及其制备方法 |
| CA3243030A1 (en) * | 2021-12-21 | 2025-02-26 | Amgen Inc. | DCAF4L2 SPECIFIC T LYMPHOCYTE RECEPTORS |
| CN114276418B (zh) * | 2021-12-28 | 2024-06-25 | 中国科学技术大学 | 一种可用于调控微管、治疗脱髓鞘病变靶向治疗的rna |
| CN114350800B (zh) * | 2021-12-29 | 2024-03-19 | 中南大学湘雅医院 | Sphk1在制备pd-l1/pd-1单抗肿瘤免疫治疗药物中的应用 |
| CN114410778B (zh) * | 2021-12-29 | 2024-03-19 | 中南大学湘雅医院 | Pf543在制备pd-l1/pd-1单抗肿瘤免疫治疗药物中的应用 |
| CN114384032B (zh) * | 2022-01-17 | 2023-07-14 | 云南大学 | 诺如病毒检测探针和非诊断目的检测诺如病毒的方法 |
| US20250108134A1 (en) * | 2022-01-28 | 2025-04-03 | Beijing Changping Laboratory | Circular rna vaccines and methods of use thereof |
| JP2025503994A (ja) | 2022-01-28 | 2025-02-06 | ビオンテック・ソシエタス・エウロパエア | コロナウイルスワクチン |
| CN115058388A (zh) * | 2022-03-14 | 2022-09-16 | 福建医科大学附属协和医院 | 间充质干细胞创面修复优势功能亚群及其鉴定和应用 |
| CN114561389A (zh) * | 2022-03-15 | 2022-05-31 | 南通市肿瘤医院 | Vrk1表达抑制剂及其应用 |
| CN114621962B (zh) * | 2022-03-21 | 2024-05-14 | 广西大学 | 花生AhBI-1基因VIGS沉默体系 |
| US12416044B2 (en) * | 2022-03-21 | 2025-09-16 | Abclonal Science, Inc. | T4 DNA ligase variants with increased ligation efficiency |
| CN114410607A (zh) * | 2022-03-22 | 2022-04-29 | 上海威高医疗技术发展有限公司 | 嗜热羧酸酯酶突变体及其应用 |
| CN119403568A (zh) * | 2022-04-07 | 2025-02-07 | 艾丽塔生物治疗剂公司 | 用于治疗癌症的组合物和方法 |
| US20250251394A1 (en) * | 2022-04-12 | 2025-08-07 | Concordia University | Aptamer-based electrochemical drug detection assay |
| CN115219720A (zh) * | 2022-05-20 | 2022-10-21 | 上饶师范学院 | 靶向分子atx在乙肝阳性肝癌中的应用及其研究方法 |
| CN114702569B (zh) * | 2022-05-25 | 2023-01-10 | 深圳吉诺因生物科技有限公司 | Pd-l1相关疫苗及其应用 |
| CN114703287B (zh) * | 2022-06-06 | 2022-08-12 | 江苏省肿瘤医院 | CXorf56基因在治疗三阴性乳腺癌中的应用 |
| US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
| CN114916502B (zh) * | 2022-07-07 | 2023-06-16 | 电子科技大学 | 一种视网膜色素变性疾病模型的构建方法和应用 |
| CN116286990A (zh) * | 2022-09-08 | 2023-06-23 | 南开大学 | 特异性靶向肿瘤和转移抑制的细胞膜来源纳米囊泡的制备方法与应用 |
| UY40490A (es) | 2022-10-17 | 2024-04-30 | Pfizer | Vacunas de combinación para prevenir y/o tratar múltiples agentes infecciosos |
| WO2024083345A1 (en) | 2022-10-21 | 2024-04-25 | BioNTech SE | Methods and uses associated with liquid compositions |
| WO2024089638A1 (en) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine |
| CN116254253B (zh) * | 2022-11-11 | 2024-06-28 | 浙大宁波理工学院 | 一种通过dna合成改组组合突变获得的谷氨酸脱羧酶突变体及应用 |
| CN115472216B (zh) * | 2022-11-14 | 2023-03-24 | 神州医疗科技股份有限公司 | 基于数据集成的肿瘤跨适应症联合用药推荐方法和系统 |
| CN116083353B (zh) * | 2022-12-02 | 2025-10-17 | 唐颐生物医学(天津)有限公司 | 一种过表达Anxa1的脐带间充质干细胞外泌体及其制备方法和应用 |
| CN115814605B (zh) * | 2022-12-06 | 2024-04-12 | 浙江大学 | 一种废弃反渗透膜修复剂及修复方法 |
| CN116271007B (zh) * | 2022-12-26 | 2025-10-03 | 浙江大学 | 一种用于治疗炎症性肠病的药物 |
| CN116236584B (zh) * | 2023-02-20 | 2024-03-22 | 四川大学 | 一种用于高效递送siRNA的多糖-多肽偶联物 |
| CN116334083B (zh) * | 2023-02-24 | 2025-06-20 | 青岛农业大学 | 花生U6启动子及其在花生CRISPR-Cas9基因编辑中的应用 |
| CN116474080B (zh) * | 2023-04-20 | 2023-12-22 | 新疆农垦科学院 | 一种细粒棘球绦虫表面展示型酿酒酵母口服疫苗及其构建方法和应用 |
| NL2034658B1 (en) * | 2023-04-21 | 2024-10-28 | Academisch Ziekenhuis Leiden | TIMP3-derived TEIPP neoantigens and uses thereof |
| CN116555286B (zh) * | 2023-04-28 | 2024-05-14 | 昆明理工大学 | 三七富含脯氨酸蛋白基因PnPRPL1及其应用 |
| CN116514115B (zh) * | 2023-05-05 | 2025-05-13 | 大连医科大学 | 一种巯基烟酸与金纳米粒子修饰氧化石墨烯材料及其制备方法和应用 |
| US12502424B2 (en) | 2023-05-05 | 2025-12-23 | Sanofi Pasteur Inc. | Compositions for use in treatment of acne |
| AU2024278682A1 (en) | 2023-05-26 | 2025-11-27 | CureVac SE | Cancer antigens |
| CN116637123B (zh) * | 2023-06-07 | 2024-02-13 | 上海市东方医院(同济大学附属东方医院) | 敲降或下调C15orf39基因表达的试剂在制备治疗胃癌的药物中的应用 |
| EP4484954A1 (en) * | 2023-06-29 | 2025-01-01 | Uniwersytet Gdanski | Mhc class i restricted immunopeptide pattern for generation of anti-nsclc vaccines |
| WO2025064738A1 (en) * | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Dntt 250-258 off-target peptides and uses thereof |
| CN117169519B (zh) * | 2023-10-26 | 2024-01-30 | 艾康生物技术(杭州)有限公司 | 用于检测样本中tt3和/或tt4的解离剂和试剂盒 |
| WO2025103803A1 (en) | 2023-11-13 | 2025-05-22 | CureVac SE | Immunotherapy against neuronal and brain tumors |
| CN117230077B (zh) * | 2023-11-13 | 2024-02-23 | 四川省医学科学院·四川省人民医院 | Hakai基因在RP疾病模型构建中的应用及构建方法 |
| WO2025131119A1 (en) * | 2023-12-22 | 2025-06-26 | Everest Medicines (China) Co., Ltd. | Cancer vaccines and uses thereof |
| WO2025140126A1 (en) * | 2023-12-25 | 2025-07-03 | Everest Medicines (China) Co., Ltd. | Therapeutic ly6k mrna vaccine for cancer |
| WO2025146130A1 (en) * | 2024-01-04 | 2025-07-10 | Everest Medicines (China) Co., Ltd. | Therapeutic BIRC5 mRNA Vaccine for Cancer |
| WO2025146077A1 (en) * | 2024-01-04 | 2025-07-10 | Everest Medicines (China) Co., Ltd. | Cancer vaccines and uses thereof |
| WO2025148611A1 (zh) * | 2024-01-12 | 2025-07-17 | 新牛(郑州)生物科技有限公司 | 肿瘤抗原肽融合蛋白及其组合物的基因工程化递送和应用 |
| CN117986344B (zh) * | 2024-02-05 | 2025-12-02 | 浙江大学 | 一种靶向线粒体核糖核酸酶p的多肽及应用 |
| CN118516398B (zh) * | 2024-02-26 | 2025-04-22 | 四川农业大学 | 水稻OsMED23基因、其编码蛋白及其应用 |
| CN118389553A (zh) * | 2024-03-01 | 2024-07-26 | 中国科学技术大学 | 免疫增效rna分子及其组合物、疫苗与试剂盒 |
| KR20250148433A (ko) * | 2024-03-29 | 2025-10-14 | 한미약품 주식회사 | 복수 kras 변이 펩티드가 연결된 항원 펩티드, 이를 코딩하는 핵산 및 이의 용도 |
| CN118006766B (zh) * | 2024-04-09 | 2024-06-28 | 鄂尔多斯市中心医院(内蒙古自治区超声影像研究所) | Pola2在诊断代谢综合征中的应用 |
| CN118546871B (zh) * | 2024-05-10 | 2025-05-06 | 未来智人再生医学研究院(广州)有限公司 | 一种人多能干细胞分化为间充质干细胞的方法 |
| WO2025242815A1 (en) | 2024-05-23 | 2025-11-27 | CureVac SE | Immunotherapy of squamous cell carcinoma |
| CN118460649B (zh) * | 2024-07-10 | 2024-12-13 | 凯莱英医药集团(天津)股份有限公司 | 一种Vutrisiran的制备方法 |
| CN118530376B (zh) * | 2024-07-26 | 2024-11-26 | 英特菲尔(成都)生物制品有限责任公司 | 一种具有修复抗皱活性的弹性蛋白及其制备方法与应用 |
| CN119082106B (zh) * | 2024-07-30 | 2025-09-30 | 福建中医药大学 | 一种抑制pno1基因表达的核酸分子及相关产品和用途 |
| CN118879730B (zh) * | 2024-08-08 | 2025-03-21 | 宁波大学 | 小麦TaHAKAI基因在调控小麦黄花叶病抗性中的应用 |
| CN119464240B (zh) * | 2024-08-19 | 2025-11-07 | 浙江理工大学绍兴生物医药研究院有限公司 | 一种突变型高稳定的过氧化氢酶及其构建方法 |
| CN119464217A (zh) * | 2024-11-01 | 2025-02-18 | 天津外泌体科技有限公司 | 一种囊泡及其作为标准品的应用 |
| CN119390756B (zh) * | 2024-11-04 | 2025-12-09 | 南京大学 | 一类基于d构型二苯丙氨酸的拟肽及其应用 |
| CN119120482B (zh) * | 2024-11-08 | 2025-02-14 | 中国医学科学院医学生物学研究所 | E3泛素连接酶rnf181基因表达抑制剂在制备预防和/或治疗hsv-1病毒感染药物中的应用 |
Family Cites Families (172)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU649066B2 (en) | 1990-07-25 | 1994-05-12 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
| US5633234A (en) * | 1993-01-22 | 1997-05-27 | The Johns Hopkins University | Lysosomal targeting of immunogens |
| US5773244A (en) | 1993-05-19 | 1998-06-30 | Regents Of The University Of California | Methods of making circular RNA |
| WO1995007707A1 (en) | 1993-09-14 | 1995-03-23 | Cytel Corporation | Alteration of immune response using pan dr-binding peptides |
| US5534499A (en) | 1994-05-19 | 1996-07-09 | The University Of British Columbia | Lipophilic drug derivatives for use in liposomes |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| DE69737659T2 (de) | 1996-06-14 | 2007-12-27 | Meiji Dairies Corp. | Peptide aus t-zellepitopen |
| JP4382163B2 (ja) * | 1997-03-27 | 2009-12-09 | ザ カウンシル オブ ザ クイーンズランド インスティチュート オブ メディカル リサーチ | ターゲッティング分子を用いた免疫応答の増強 |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| JP2002520000A (ja) * | 1998-05-13 | 2002-07-09 | エピミューン, インコーポレイテッド | 免疫応答を刺激するための発現ベクターおよびそのベクターの使用方法 |
| US6210931B1 (en) | 1998-11-30 | 2001-04-03 | The United States Of America As Represented By The Secretary Of Agriculture | Ribozyme-mediated synthesis of circular RNA |
| EP1246597B1 (en) | 1999-08-03 | 2015-01-14 | The Ohio State University | Polypeptides and polynucleotides for enhancing immune reactivity to her-2 protein |
| HUP0300067A3 (en) | 2000-02-21 | 2010-03-29 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| AU2001278117A1 (en) | 2000-08-03 | 2002-02-18 | Johns Hopkins University | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen |
| US20030138769A1 (en) | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| US20030091590A1 (en) * | 2001-01-17 | 2003-05-15 | Pomerantz Roger J. | Recombinant rhabdoviruses as live-viral vaccines |
| ATE463505T1 (de) * | 2001-04-20 | 2010-04-15 | Inst Systems Biology | Toll-ähnlichen-rezeptor-5-liganden und verwendungsverfahren |
| EP2305699B1 (de) | 2001-06-05 | 2014-08-13 | CureVac GmbH | Stabilisierte mRNA mit erhöhtem G/C-Gehalt und optimierter Codon Usage für die Impfung gegen Schlafkrankheit, Leishmaniose und Toxoplasmose |
| DE10162480A1 (de) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
| AU2003277865B2 (en) | 2002-06-25 | 2008-08-21 | City Of Hope | Adjuvant-free peptide vaccine |
| DE10229872A1 (de) | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immunstimulation durch chemisch modifizierte RNA |
| EP2308968A1 (en) * | 2002-11-26 | 2011-04-13 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| CU23204A1 (es) | 2002-12-27 | 2007-05-18 | Ct Ingenieria Genetica Biotech | Combinaciones de factores reguladores del crecimiento y hormonas para el tratamiento de neoplasias |
| DE10335833A1 (de) | 2003-08-05 | 2005-03-03 | Curevac Gmbh | Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie |
| DE10347710B4 (de) * | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
| DE102004042546A1 (de) | 2004-09-02 | 2006-03-09 | Curevac Gmbh | Kombinationstherapie zur Immunstimulation |
| US20090214598A1 (en) | 2005-04-19 | 2009-08-27 | Eli Lilly And Company | Monovalent and polyvalent synthetic polysaccharide antigens for immunological intervention in disease |
| DE102005023170A1 (de) | 2005-05-19 | 2006-11-23 | Curevac Gmbh | Optimierte Formulierung für mRNA |
| PL2578685T3 (pl) * | 2005-08-23 | 2020-01-31 | The Trustees Of The University Of Pennsylvania | Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania |
| MX2008012392A (es) * | 2006-03-27 | 2008-12-17 | Globeimmune Inc | Mutacion de ras, y composiciones y metodos relacionados con la misma. |
| JP2009544754A (ja) | 2006-07-28 | 2009-12-17 | アプライド バイオシステムズ, エルエルシー | ジヌクレオチドmrnaキャップアナログ |
| DE102006035618A1 (de) | 2006-07-31 | 2008-02-07 | Curevac Gmbh | Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz |
| JP5750600B2 (ja) | 2006-08-11 | 2015-07-22 | ライフ・サイエンシーズ・リサーチ・パートナーズ・フェレニゲング・ゾンデル・ウィンストーメルクLife Sciences Research Partners Vzw | 免疫原性ペプチドおよび免疫障害におけるその使用 |
| DE102006061015A1 (de) | 2006-12-22 | 2008-06-26 | Curevac Gmbh | Verfahren zur Reinigung von RNA im präparativen Maßstab mittels HPLC |
| DE102007001370A1 (de) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-kodierte Antikörper |
| WO2008157688A2 (en) | 2007-06-19 | 2008-12-24 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap |
| WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| WO2009046738A1 (en) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition for treating lung cancer, particularly of non-small lung cancers (nsclc) |
| WO2009046739A1 (en) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition for treating prostate cancer (pca) |
| JP5749494B2 (ja) | 2008-01-02 | 2015-07-15 | テクミラ ファーマシューティカルズ コーポレイション | 核酸の送達のための改善された組成物および方法 |
| US9226959B2 (en) | 2008-01-31 | 2016-01-05 | Curevac Ag | Nucleic acids comprising formula (NuGlXmGnNv)a and derivatives thereof as immunostimulating agent/adjuvant |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| PL215513B1 (pl) | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| EP2161279A1 (en) | 2008-08-29 | 2010-03-10 | Centre National de la Recherche Scientifique | Synthetic peptides corresponding to overlapping neutralizing determinants in the CBD1 epitope induce broadly neutralizing antibodies |
| WO2010037408A1 (en) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
| JP5777519B2 (ja) | 2008-10-09 | 2015-09-09 | テクミラ ファーマシューティカルズ コーポレイション | 改良されたアミノ脂質および核酸の送達方法 |
| WO2010048536A2 (en) | 2008-10-23 | 2010-04-29 | Alnylam Pharmaceuticals, Inc. | Processes for preparing lipids |
| CA3006395C (en) | 2008-11-07 | 2022-05-31 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| PL2355851T3 (pl) | 2008-11-10 | 2018-08-31 | Arbutus Biopharma Corporation | Nowe lipidy i kompozycje do dostarczania środków terapeutycznych |
| WO2010087791A1 (en) | 2009-01-27 | 2010-08-05 | Utc Power Corporation | Distributively cooled, integrated water-gas shift reactor and vaporizer |
| EP3243504A1 (en) | 2009-01-29 | 2017-11-15 | Arbutus Biopharma Corporation | Improved lipid formulation |
| CA2756996C (en) | 2009-04-01 | 2018-12-11 | University Of Miami | Vaccine compositions and methods of use thereof |
| US8467858B2 (en) | 2009-04-29 | 2013-06-18 | Tomophase Corporation | Image-guided thermotherapy based on selective tissue thermal treatment |
| US8883202B2 (en) | 2009-05-05 | 2014-11-11 | Tekmira Pharmaceuticals Corporation | Lipid compositions |
| LT2440183T (lt) | 2009-06-10 | 2018-08-10 | Arbutus Biopharma Corporation | Patobulinta lipido kompozicija |
| EP2281579A1 (en) | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
| US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| WO2011069529A1 (en) | 2009-12-09 | 2011-06-16 | Curevac Gmbh | Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids |
| CN103002878B (zh) | 2010-04-09 | 2015-07-01 | 帕西拉制药有限公司 | 用于配制大直径合成膜囊泡的方法 |
| NZ605079A (en) | 2010-06-03 | 2015-08-28 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
| PL2590626T3 (pl) | 2010-07-06 | 2016-04-29 | Glaxosmithkline Biologicals Sa | Liposomy z lipidami o korzystnej wartości pka do dostarczania rna |
| CA2804591C (en) | 2010-07-06 | 2019-01-22 | Novartis Ag | Cationic oil-in-water emulsions |
| CN107648604A (zh) | 2010-07-30 | 2018-02-02 | 库瑞瓦格股份公司 | 聚合物载体运载物复合物及聚合物载体的用途 |
| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| WO2012030901A1 (en) | 2010-08-31 | 2012-03-08 | Novartis Ag | Small liposomes for delivery of immunogen-encoding rna |
| SI3970742T1 (sl) | 2010-08-31 | 2022-08-31 | Glaxosmithkline Biologicals S.A. | Pegilirani liposomi za dostavo RNA, ki kodira imunogen |
| CN103384515B (zh) | 2010-08-31 | 2017-02-15 | 诺华有限公司 | 适用于脂质体递送编码蛋白质的rna的脂质 |
| WO2012089225A1 (en) | 2010-12-29 | 2012-07-05 | Curevac Gmbh | Combination of vaccination and inhibition of mhc class i restricted antigen presentation |
| WO2012116715A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in newborns and infants |
| WO2012113413A1 (en) | 2011-02-21 | 2012-08-30 | Curevac Gmbh | Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates |
| WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
| SG10201605537XA (en) | 2011-07-06 | 2016-09-29 | Novartis Ag | Liposomes having useful n:p ratio for delivery of rna molecules |
| CN114835823A (zh) * | 2011-07-29 | 2022-08-02 | 宾夕法尼亚大学董事会 | 转换共刺激受体 |
| PT2750707T (pt) | 2011-08-31 | 2019-01-23 | Glaxosmithkline Biologicals Sa | Lipossomas peguilados para distribuição de arn que codifica imunogénio |
| US8969545B2 (en) | 2011-10-18 | 2015-03-03 | Life Technologies Corporation | Alkynyl-derivatized cap analogs, preparation and uses thereof |
| EP2623121A1 (en) | 2012-01-31 | 2013-08-07 | Bayer Innovation GmbH | Pharmaceutical composition comprising a polymeric carrier cargo complex and an antigen |
| WO2013113326A1 (en) | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen |
| WO2013113325A1 (en) | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Negatively charged nucleic acid comprising complexes for immunostimulation |
| WO2013120497A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein |
| WO2013120500A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| WO2013120498A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen |
| SG10201607966UA (en) | 2012-03-27 | 2016-11-29 | Curevac Ag | Artificial nucleic acid molecules comprising a 5'top utr |
| MX2019002345A (es) | 2012-03-27 | 2022-08-24 | Curevac Ag | Moleculas artificiales de acido nucleico para la expresion mejorada de proteina o peptido. |
| CA2866955A1 (en) * | 2012-03-27 | 2013-10-03 | Curevac Gmbh | Artificial nucleic acid molecules |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| ES2719598T3 (es) | 2012-05-25 | 2019-07-11 | Curevac Ag | Inmovilización reversible y/o liberación controlada de ácidos nucleicos contenidos en nanopartículas mediante revestimientos poliméricos (biodegradables) |
| AU2013204922B2 (en) * | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| MX385338B (es) | 2013-02-22 | 2025-03-18 | CureVac SE | Combinación de vacunación e inhibición de la trayectoria pd-1. |
| AU2014310932B2 (en) | 2013-08-21 | 2019-06-06 | CureVac SE | Composition and vaccine for treating lung cancer |
| WO2015024669A1 (en) | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Combination vaccine |
| KR20160043103A (ko) | 2013-08-21 | 2016-04-20 | 큐어백 아게 | 전립선암 치료를 위한 조성물 및 백신 |
| ES2747762T3 (es) | 2013-08-21 | 2020-03-11 | Curevac Ag | Vacuna contra el virus respiratorio sincitial (RSV) |
| WO2015024665A1 (en) | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Rabies vaccine |
| MX2016002152A (es) | 2013-08-21 | 2017-01-05 | Curevac Ag | Metodo para aumentar la expresion de proteinas codificadas por arn. |
| EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| ES2806575T3 (es) | 2013-11-01 | 2021-02-18 | Curevac Ag | ARN modificado con propiedades inmunoestimuladoras disminuidas |
| JP6486955B2 (ja) | 2013-11-18 | 2019-03-20 | アークトゥルス セラピューティクス, インコーポレイテッド | Rna送達のためのイオン化可能なカチオン性脂質 |
| GB201321384D0 (en) * | 2013-12-04 | 2014-01-15 | Isis Innovation | Molecular adjuvant |
| WO2015100219A1 (en) * | 2013-12-23 | 2015-07-02 | Oncomed Pharmaceuticals, Inc. | Immunotherapy with binding agents |
| JP6704850B2 (ja) | 2013-12-30 | 2020-06-03 | キュアバック アーゲー | 人工核酸分子 |
| JP6584414B2 (ja) | 2013-12-30 | 2019-10-02 | キュアバック アーゲー | 人工核酸分子 |
| SG10201805660WA (en) | 2013-12-30 | 2018-08-30 | Curevac Ag | Methods for rna analysis |
| EP4303229A3 (en) * | 2014-01-21 | 2024-04-17 | Novartis AG | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
| ES2754239T3 (es) | 2014-03-12 | 2020-04-16 | Curevac Ag | Combinación de vacunación y agonistas de OX40 |
| WO2015149944A2 (en) | 2014-04-01 | 2015-10-08 | Curevac Gmbh | Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant |
| PL3155129T3 (pl) | 2014-06-10 | 2019-09-30 | Curevac Ag | Sposób zwiększania wytwarzania RNA |
| IL298516B2 (en) | 2014-06-25 | 2025-03-01 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle compositions for nucleic acid delivery |
| EP3169335B8 (en) | 2014-07-16 | 2019-10-09 | ModernaTX, Inc. | Circular polynucleotides |
| BR112017005390A2 (pt) * | 2014-09-17 | 2017-12-12 | Novartis Ag | células citotóxicas alvo com receptores quiméricos para imunoterapia adotiva |
| DK3708668T3 (da) | 2014-12-12 | 2022-09-26 | Curevac Ag | Kunstigt nukleinsyremolekyle til forbedret proteinudtrykkelse |
| CA2962849A1 (en) | 2014-12-16 | 2016-06-23 | Curevac Ag | Ebolavirus and marburgvirus vaccines |
| WO2016107877A1 (en) | 2014-12-30 | 2016-07-07 | Curevac Ag | Artificial nucleic acid molecules |
| EP3247363A4 (en) | 2015-01-21 | 2018-10-03 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| WO2016118725A1 (en) | 2015-01-23 | 2016-07-28 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| EP3283059B1 (en) | 2015-04-13 | 2024-01-03 | CureVac Manufacturing GmbH | Method for producing rna compositions |
| EP3283125B1 (en) | 2015-04-17 | 2021-12-29 | CureVac Real Estate GmbH | Lyophilization of rna |
| AU2016251687C1 (en) | 2015-04-22 | 2023-07-27 | CureVac SE | RNA containing composition for treatment of tumor diseases |
| EP3289077B1 (en) | 2015-04-30 | 2020-04-15 | CureVac AG | Method for in vitro transcription using an immobilized restriction enzyme |
| ES2897823T3 (es) | 2015-04-30 | 2022-03-02 | Curevac Ag | Poli(N)polimerasa inmovilizada |
| EP3294885B1 (en) | 2015-05-08 | 2020-07-01 | CureVac Real Estate GmbH | Method for producing rna |
| US11559570B2 (en) | 2015-05-15 | 2023-01-24 | CureVac SE | Prime-boost regimens involving administration of at least one mRNA construct |
| EP3297682B1 (en) | 2015-05-20 | 2021-07-14 | CureVac AG | Dry powder composition comprising long-chain rna |
| WO2016184575A1 (en) | 2015-05-20 | 2016-11-24 | Curevac Ag | Dry powder composition comprising long-chain rna |
| WO2016193226A1 (en) | 2015-05-29 | 2016-12-08 | Curevac Ag | Method for adding cap structures to rna using immobilized enzymes |
| DE202016009003U1 (de) | 2015-05-29 | 2021-05-28 | Curevac Real Estate Gmbh | Zusammensetzung umfassend in vitro transkribierte RNA erhältlich durch ein Verfahren zur Herstellung und Reinigung von RNA mit mindestens einem Schritt mit einer tangentialen Flussfiltration |
| WO2016203025A1 (en) * | 2015-06-17 | 2016-12-22 | Curevac Ag | Vaccine composition |
| US20190017100A1 (en) | 2015-07-01 | 2019-01-17 | Curevac Ag | Method for analysis of an rna molecule |
| WO2017009376A1 (en) | 2015-07-13 | 2017-01-19 | Curevac Ag | Method of producing rna from circular dna and corresponding template dna |
| WO2017021546A1 (en) | 2015-08-05 | 2017-02-09 | Curevac Ag | Epidermal mrna vaccine |
| DK3332019T3 (da) | 2015-08-07 | 2020-02-17 | Curevac Ag | Fremgangsmåde til in vivo-produktionen af rna i en værtscelle |
| DK3334828T3 (en) | 2015-08-10 | 2020-12-14 | Curevac Real Estate Gmbh | Fremgangsmåde til at øge replikationen af et cirkulært dna-molekyle |
| EP4424835A3 (en) | 2015-09-21 | 2024-10-23 | TriLink BioTechnologies, LLC | Compositions and methods for synthesizing 5'-capped rnas |
| EP3362576A1 (en) | 2015-10-12 | 2018-08-22 | CureVac AG | Automated method for isolation, selection and/or detection of microorganisms or cells comprised in a solution |
| US20190218546A1 (en) | 2015-10-16 | 2019-07-18 | Modernatx, Inc. | Mrna cap analogs with modified phosphate linkage |
| US11866754B2 (en) | 2015-10-16 | 2024-01-09 | Modernatx, Inc. | Trinucleotide mRNA cap analogs |
| WO2017066791A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Sugar substituted mrna cap analogs |
| WO2017066789A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Mrna cap analogs with modified sugar |
| WO2017066782A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Hydrophobic mrna cap analogs |
| CA3001014A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Mrna cap analogs and methods of mrna capping |
| CN118846026A (zh) | 2015-10-22 | 2024-10-29 | 摩登纳特斯有限公司 | 广谱流感病毒疫苗 |
| JP6921833B2 (ja) | 2015-10-22 | 2021-08-18 | モデルナティーエックス, インコーポレイテッド | ヒトサイトメガロウイルスワクチン |
| EP4582098A3 (en) | 2015-11-09 | 2025-12-24 | CureVac SE | Optimized nucleic acid molecules |
| US11413346B2 (en) | 2015-11-09 | 2022-08-16 | Curevac Ag | Rotavirus vaccines |
| WO2017099823A1 (en) | 2015-12-10 | 2017-06-15 | Modernatx, Inc. | Compositions and methods for delivery of therapeutic agents |
| EP3394237A1 (en) | 2015-12-21 | 2018-10-31 | CureVac AG | Inlay for a culture plate and corresponding method for preparing a culture plate system with such inlay |
| EP4036079B1 (en) | 2015-12-22 | 2025-11-19 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of agents |
| US11684665B2 (en) | 2015-12-22 | 2023-06-27 | CureVac SE | Method for producing RNA molecule compositions |
| US11248223B2 (en) | 2015-12-23 | 2022-02-15 | Curevac Ag | Method of RNA in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof |
| US9834510B2 (en) | 2015-12-30 | 2017-12-05 | Arcturus Therapeutics, Inc. | Aromatic ionizable cationic lipid |
| US20210180106A1 (en) | 2016-02-12 | 2021-06-17 | Curevac Ag | Method for analyzing rna |
| US20190049414A1 (en) | 2016-02-15 | 2019-02-14 | Curevac Ag | Method for analyzing by-products of rna in vitro transcription |
| WO2017140905A1 (en) | 2016-02-17 | 2017-08-24 | Curevac Ag | Zika virus vaccine |
| WO2017149139A1 (en) | 2016-03-03 | 2017-09-08 | Curevac Ag | Rna analysis by total hydrolysis |
| WO2017162297A1 (en) | 2016-03-24 | 2017-09-28 | Curevac Ag | Immobilized inorganic pyrophosphatase (ppase) |
| US20180237789A1 (en) | 2016-04-16 | 2018-08-23 | Jiangnan University | Mortierella alpine uracil auxotroph with ura5 gene knocked out through homologous recombination |
| EP4487869A3 (en) | 2016-04-22 | 2025-07-30 | CureVac SE | Rna encoding a tumor antigen |
| EP3448427A1 (en) | 2016-04-29 | 2019-03-06 | CureVac AG | Rna encoding an antibody |
| EP3452101A2 (en) | 2016-05-04 | 2019-03-13 | CureVac AG | Rna encoding a therapeutic protein |
| US20180126003A1 (en) | 2016-05-04 | 2018-05-10 | Curevac Ag | New targets for rna therapeutics |
| EP3452086A1 (en) | 2016-05-04 | 2019-03-13 | CureVac AG | Influenza mrna vaccines |
| US11141474B2 (en) | 2016-05-04 | 2021-10-12 | Curevac Ag | Artificial nucleic acid molecules encoding a norovirus antigen and uses thereof |
| WO2017203008A1 (en) | 2016-05-25 | 2017-11-30 | Curevac Ag | Novel biomarkers |
| US20190336608A1 (en) | 2016-06-09 | 2019-11-07 | Curevac Ag | Cationic carriers for nucleic acid delivery |
| WO2017212008A1 (en) | 2016-06-09 | 2017-12-14 | Curevac Ag | Hybrid carriers for nucleic acid cargo |
| EP3468608A1 (en) | 2016-06-09 | 2019-04-17 | CureVac AG | Hybrid carriers for nucleic acid cargo |
| BR112018075479A2 (pt) | 2016-06-09 | 2019-03-19 | Curevac Ag | portadores híbridos para carga de ácido nucleico |
| BR112019000598A2 (pt) | 2016-08-19 | 2019-07-02 | Curevac Ag | rna para terapia de câncer |
| WO2018058088A1 (en) * | 2016-09-26 | 2018-03-29 | SOLA Biosciences, LLC | Cell-associated secretion-enhancing fusion proteins |
| US10487105B2 (en) | 2016-10-19 | 2019-11-26 | Arcturus Therapeutics, Inc. | Trinucleotide MRNA cap analogs |
| US20200163878A1 (en) | 2016-10-26 | 2020-05-28 | Curevac Ag | Lipid nanoparticle mrna vaccines |
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