BR112017013565B1 - Seringa para retenção e mistura de primeira e segunda substâncias - Google Patents

Seringa para retenção e mistura de primeira e segunda substâncias Download PDF

Info

Publication number
BR112017013565B1
BR112017013565B1 BR112017013565-5A BR112017013565A BR112017013565B1 BR 112017013565 B1 BR112017013565 B1 BR 112017013565B1 BR 112017013565 A BR112017013565 A BR 112017013565A BR 112017013565 B1 BR112017013565 B1 BR 112017013565B1
Authority
BR
Brazil
Prior art keywords
syringe
plunger
vacuum
vacuum chamber
valve
Prior art date
Application number
BR112017013565-5A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112017013565A2 (pt
Inventor
Kristian Larsen
Original Assignee
Ferrosan Medical Devices A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan Medical Devices A/S filed Critical Ferrosan Medical Devices A/S
Publication of BR112017013565A2 publication Critical patent/BR112017013565A2/pt
Publication of BR112017013565B1 publication Critical patent/BR112017013565B1/pt

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/19Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/00491Surgical glue applicators
    • A61B2017/00495Surgical glue applicators for two-component glue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3128Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501Means for blocking or restricting the movement of the rod or piston

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
BR112017013565-5A 2014-12-24 2015-12-21 Seringa para retenção e mistura de primeira e segunda substâncias BR112017013565B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14200323 2014-12-24
EP14200323.5 2014-12-24
PCT/EP2015/080761 WO2016102446A1 (en) 2014-12-24 2015-12-21 Syringe for retaining and mixing first and second substances

Publications (2)

Publication Number Publication Date
BR112017013565A2 BR112017013565A2 (pt) 2018-03-06
BR112017013565B1 true BR112017013565B1 (pt) 2021-12-28

Family

ID=52146342

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017013565-5A BR112017013565B1 (pt) 2014-12-24 2015-12-21 Seringa para retenção e mistura de primeira e segunda substâncias

Country Status (9)

Country Link
US (1) US10653837B2 (https=)
EP (1) EP3237041B1 (https=)
JP (1) JP6747650B2 (https=)
CN (1) CN107206165B (https=)
AU (1) AU2015371184B2 (https=)
BR (1) BR112017013565B1 (https=)
CA (1) CA2970710A1 (https=)
RU (1) RU2705905C2 (https=)
WO (1) WO2016102446A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104159527B (zh) 2012-03-06 2017-04-12 弗罗桑医疗设备公司 包含止血糊剂的压力容器
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
JP6390873B2 (ja) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー/エス 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ
BR112016013322B1 (pt) 2013-12-11 2020-07-21 Ferrosan Medical Devices A/S métodos para preparação de uma composição seca e para reconstituir uma composição seca, composição seca, uso de uma composição seca, e, kit
BR112017007466B1 (pt) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca
CA2986981A1 (en) * 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
GB2556088A (en) * 2016-11-18 2018-05-23 Owen Mumford Ltd Packaging and devices for mixing medicament substances
CN107028762B (zh) * 2017-05-27 2023-09-15 南京云科芝生健康科技有限公司 一种定量配比输液袋
JP7366894B2 (ja) * 2017-11-17 2023-10-23 サノフイ デバイスならびに混合および/または再構成方法
EP4321182A3 (en) * 2018-05-09 2024-05-29 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
US20200009017A1 (en) * 2018-07-09 2020-01-09 Vivek K. Sharma Multi-volume drug delivery system with vacuum-assisted mixing and/or delivery
CN109481144B (zh) * 2018-11-06 2020-11-27 苏州喜全软件科技有限公司 防误操作的内抽外注型鼓膜穿刺、鼓室内注射医疗装置
US11331431B2 (en) 2018-11-24 2022-05-17 Gemini Medical, Inc. Syringe for injecting medication with openable and closable stopper
CN109668873B (zh) * 2018-12-05 2021-03-16 山东恒业生物技术有限公司 一种活载体疫苗活性检测装置及其使用方法
US20230218874A1 (en) * 2019-05-28 2023-07-13 Anergent Pharmaceuticals, Inc. Swab delivery system
IL272145A (en) * 2020-01-20 2021-07-29 Stem Cell Medicine Ltd Cosmetic compositions with protein concentrate from conditioned medium of adipose-derived stem cells
CN111840763A (zh) * 2020-08-18 2020-10-30 上海微创医疗器械(集团)有限公司 一种液体输送装置及治疗装置
WO2022068893A1 (zh) * 2020-09-30 2022-04-07 广州迈普再生医学科技股份有限公司 医用胶喷涂装置
US12156997B2 (en) * 2020-10-11 2024-12-03 Dali Medical Devices Ltd Dual chamber syringe with a restricting element and methods of use thereof
DK4135830T3 (da) 2020-12-23 2024-10-28 Tolmar International Ltd Systemer og fremgangsmåder til blanding af sprøjteventilanordninger
USD1029245S1 (en) 2022-06-22 2024-05-28 Tolmar International Limited Syringe connector
WO2024062668A1 (ja) * 2022-09-20 2024-03-28 テルモ株式会社 プレフィルドシリンジ、先端部材、シリンジ外筒及びプレフィルドシリンジの製造方法
US20240261510A1 (en) * 2023-02-03 2024-08-08 Becton, Dickinson And Company Single-use syringe with syringe lock

Family Cites Families (525)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2899362A (en) 1959-08-11 Hemostatic sponges and method of
US2465357A (en) 1944-08-14 1949-03-29 Upjohn Co Therapeutic sponge and method of making
US2465860A (en) 1945-10-13 1949-03-29 Standard Manifold Company Inc Carbon holder
GB648619A (en) 1947-03-19 1951-01-10 Ferrosan As Process of producing sponges of gelatine and the like proteins
US2507244A (en) 1947-04-14 1950-05-09 Upjohn Co Surgical gelatin dusting powder and process for preparing same
CH264752A (de) 1947-06-03 1949-10-31 Hoffmann La Roche Verfahren zur Herstellung von Trägern für Arzneimittel.
GB697603A (en) 1948-10-06 1953-09-23 Sydney Arthur Gladstone Improvements in or relating to method of and devices for obtaining tissue from a tumour carried by a patient
US3089815A (en) 1951-10-11 1963-05-14 Lieb Hans Injectable pharmaceutical preparation, and a method of making same
US3224434A (en) 1962-11-06 1965-12-21 Waldemar Medical Res Foundatio Cell collector
GB1037937A (en) 1963-06-26 1966-08-03 Colgate Palmolive Co Pressurized dispensing containers
US3255752A (en) * 1965-01-28 1966-06-14 Dick Peter Hypodermic syringe
US3405712A (en) 1966-02-07 1968-10-15 Richard L. Pierick Desiccative syringe
US3869539A (en) 1966-12-01 1975-03-04 Ferrosan As Preparations containing fat-soluble vitamins in dry, particulate, free-flowing form dispersible in cold water and method of producing such preparations
US3514518A (en) 1967-12-19 1970-05-26 Pierre Charier Vadrot Process for preparation of gelatinous material from animal collagen
US3470109A (en) 1968-01-31 1969-09-30 Aloe Creme Lab Inc Method of making reconstitutable aloe gel in crystalline form
US3608593A (en) 1970-02-27 1971-09-28 Lilly Co Eli Method of filling powders into containers
US3678933A (en) 1970-07-17 1972-07-25 Moore Perk Corp Surgical sponge or bandage
US3892876A (en) 1971-11-30 1975-07-01 Leiner & Sons Wales Limited P Process of preparing freeze-dried gelatin
FR2167197B1 (fr) 1972-01-10 1974-06-21 Pont Brule Sa Compositions ameliorees contenant de la gelatine
US3899606A (en) 1972-03-31 1975-08-12 Pillsbury Co Process for the treatment of coconut and food products resulting therefrom
US3815580A (en) 1972-08-31 1974-06-11 C Oster Apparatus for and method of collecting and preserving cytologic samples
DE2316209A1 (de) 1973-03-31 1974-10-10 Transcoject Gmbh Spritze fuer medizinische und technische zwecke
US3946732A (en) 1973-08-08 1976-03-30 Ampoules, Inc. Two-chamber mixing syringe
SE420565B (sv) 1974-06-06 1981-10-19 Pharmacia Ab Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel
DE2433399C3 (de) 1974-07-11 1978-09-14 Carl Schleicher & Schuell, 3352 Einbeck Kolbenschieberpumpe, insbesondere für die Druckfiltration
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US4013078A (en) 1974-11-25 1977-03-22 Feild James Rodney Intervertebral protector means
JPS5823410B2 (ja) 1974-11-12 1983-05-14 株式会社クラレ ヒドロゲルヨウキザイ
US4006220A (en) 1975-06-04 1977-02-01 Gottlieb Sheldon K Compositions and methods useful for repairing depressed cutaneous scars
US4280954A (en) 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
US4160022A (en) 1975-09-15 1979-07-03 Colgate Palmolive Company Toothpaste
US4098728A (en) 1976-01-02 1978-07-04 Solomon Rosenblatt Medical surgical sponge and method of making same
US4150744A (en) 1976-02-27 1979-04-24 Smith & Nephew Pharmaceuticals Ltd. Packaging
JPS5329936A (en) 1976-08-31 1978-03-20 Takeda Chem Ind Ltd Antibiotic composition
SE430609B (sv) 1976-12-21 1983-11-28 Sca Development Ab Sett att ur cellulosaderivat framstella absorberande material
DE2816130A1 (de) 1977-06-10 1978-12-21 Ato Chimie Verfahren und vorrichtung zur messung des haftvermoegens eines haftklebers
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4208439A (en) 1977-10-25 1980-06-17 Societe D'assistance Technique Pour Produits Nestle S.A. Preparation of pasta
GB1584080A (en) 1977-12-05 1981-02-04 Ethicon Inc Absorbable hemostatic composition
DE2843963A1 (de) 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
US4265233A (en) 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
US4179400A (en) 1978-05-09 1979-12-18 W. R. Grace & Co. Process for preparing catalytic solutions of sulfonium salts
AT359652B (de) 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
AT359653B (de) 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
DE3036033A1 (de) 1980-09-24 1982-05-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Wundbehandlungsmittel in pulverform und verfahren zu seiner herstellung
US4300494A (en) 1979-09-26 1981-11-17 Shell Oil Company Thermal insulated intake ports
DE2943520C2 (de) 1979-10-27 1982-05-19 Fa. Carl Freudenberg, 6940 Weinheim Verfahren zur Herstellung von Kollagenschwamm für medizinische oder kosmetische Zwecke
US4292972A (en) 1980-07-09 1981-10-06 E. R. Squibb & Sons, Inc. Lyophilized hydrocolloio foam
DE3105624A1 (de) 1981-02-16 1982-09-02 Hormon-Chemie München GmbH, 8000 München Material zum abdichten und heilen von wunden
DE3267499D1 (en) 1981-03-18 1986-01-02 Fujirebio Kk Support material for use in serological testing and process for the production thereof
EP0089971B1 (en) 1981-10-06 1985-08-07 Rocep-Lusol Holdings Limited Pressurized dispensing apparatus
DE3146841A1 (de) 1981-11-26 1983-06-01 Beiersdorf Ag, 2000 Hamburg "neue wundbehandlungsmittel"
US4424208A (en) 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
DE3360633D1 (en) 1982-02-12 1985-10-03 Unitika Ltd Anti-cancer device
US4482386A (en) 1982-03-26 1984-11-13 Warner-Lambert Company Method of conditioning a water swellable hydrocolloid
US4543332A (en) 1982-03-29 1985-09-24 Miles Laboratories, Inc. Method for the preparation of spherical microorganism cell aggregates
JPS5928472A (ja) 1982-08-09 1984-02-15 Koken:Kk 細胞培養用基質およびこの基質を用いた細胞培養・分離法
EP0106648B1 (en) 1982-10-16 1988-05-18 Johnsen & Jorgensen Jaypak Limited Bag apparatus
US4540410A (en) 1982-11-16 1985-09-10 Serono Pharmaceutical Partners Lyophilized compositions, preparation and use thereof
JPS59113889A (ja) 1982-12-17 1984-06-30 Sumitomo Chem Co Ltd 固定化酵素もしくは固定化微生物菌体の製造方法
US4492305A (en) 1983-07-08 1985-01-08 Marion Laboratories, Inc. Package for collecting cultures
EP0132983B2 (en) 1983-07-14 1991-06-12 Hitachi Chemical Co., Ltd. Production of gelatin spherical gels and their use
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
JPS60110669A (ja) 1983-11-12 1985-06-17 株式会社林原生物化学研究所 圧出容器とその製造方法
US4515637A (en) 1983-11-16 1985-05-07 Seton Company Collagen-thrombin compositions
US4549554A (en) 1984-01-03 1985-10-29 Markham Charles W Aspiration biopsy device
US4522302A (en) 1984-03-05 1985-06-11 Sterling Drug Inc. Pre-sterilized medical procedure kit packages
AT389815B (de) 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US4600574A (en) 1984-03-21 1986-07-15 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Method of producing a tissue adhesive
US4837285A (en) 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
ZA851661B (en) 1984-03-29 1986-10-29 Minnesota Mining & Mfg Sorbent sheet material
JPS60214728A (ja) 1984-04-06 1985-10-28 Unitika Ltd 生理活性物質徐放性材料
SE456346B (sv) 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
JPS6144825A (ja) 1984-08-09 1986-03-04 Unitika Ltd 止血剤
GB8422950D0 (en) 1984-09-11 1984-10-17 Warne K J Hydrogel
JPS61122222A (ja) 1984-11-19 1986-06-10 Koken:Kk コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤
US5178883A (en) 1984-11-29 1993-01-12 Regents Of The University Of Minnesota Method for promoting hair growth
US5165938A (en) 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US4600533A (en) 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
JPS61209590A (ja) 1985-03-13 1986-09-17 Asama Kasei Kk 新規な固定化細胞およびそれを利用する醗酵生産法
US4997753A (en) 1985-04-04 1991-03-05 Verax Corporation Weighted collagen microsponge for immobilizing bioactive material
US4861714A (en) 1985-04-04 1989-08-29 Verax Corporation Weighted collagen microsponge for immobilizing bioactive material
US4863856A (en) 1985-04-04 1989-09-05 Verax Corporation Weighted collagen microsponge for immobilizing bioactive materials
AT382783B (de) 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5112750A (en) 1985-06-25 1992-05-12 Asama Chemical Co., Ltd. Immobilized cells and culture method utilizing the same
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US5007916A (en) 1985-08-22 1991-04-16 Johnson & Johnson Medical, Inc. Method and material for prevention of surgical adhesions
JPS6270318A (ja) 1985-09-25 1987-03-31 Nippon Kayaku Co Ltd 止血及び創傷保護剤
US4696812A (en) 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
US20020192271A1 (en) 1985-11-26 2002-12-19 Hedner Ulla Karin Elisabeth Method for causing local hemostasis and hemostatic composition for local hemostasis
US5180583A (en) 1985-11-26 1993-01-19 Hedner Ulla K E Method for the treatment of bleeding disorders
IE59361B1 (en) 1986-01-24 1994-02-09 Akzo Nv Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension
JPS62221357A (ja) 1986-03-20 1987-09-29 ジエクス株式会社 生物体表面への塗布剤
IL78826A (en) 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
US5300494A (en) 1986-06-06 1994-04-05 Union Carbide Chemicals & Plastics Technology Corporation Delivery systems for quaternary and related compounds
US4946870A (en) 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US4832686A (en) 1986-06-24 1989-05-23 Anderson Mark E Method for administering interleukin-2
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US4702737A (en) 1986-07-14 1987-10-27 Pizzino Joanne L Dual dose syringe
US4693706A (en) * 1986-08-11 1987-09-15 Mark L. Anderson Two compartment mixing syringe
US4743229A (en) 1986-09-29 1988-05-10 Collagen Corporation Collagen/mineral mixing device and method
US4965203A (en) 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
US4885161A (en) 1987-03-11 1989-12-05 Medi-Tech International Corporation Wound dressings in gelled paste form
CA1305069C (en) 1987-03-11 1992-07-14 John Cornell Wound dressings in sheet or gelled paste form
US5080893A (en) 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US5690954A (en) 1987-05-22 1997-11-25 Danbiosyst Uk Limited Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
US4887743A (en) 1987-06-10 1989-12-19 Blake William S Aerosol valve
US4752466A (en) 1987-08-31 1988-06-21 Johnson & Johnson Products, Inc. Thrombin aerosol
US5017229A (en) 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
JPS6485653A (en) 1987-09-28 1989-03-30 Terumo Corp Drug receiving container
JPH01130519A (ja) 1987-11-16 1989-05-23 Mitsubishi Electric Corp Mocvd結晶成長装置
ES2064439T3 (es) 1988-05-02 1995-02-01 Project Hear Material adhesivo quirurgico.
IT1219587B (it) 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US4936835A (en) 1988-05-26 1990-06-26 Haaga John R Medical needle with bioabsorbable tip
US5350573A (en) 1988-05-31 1994-09-27 University Of Florida Research Foundation, Inc. Method and composition for preventing surgical adhesions
US5140016A (en) 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5024841A (en) 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5447966A (en) 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US4920158A (en) 1989-10-11 1990-04-24 Medipro Sciences Limited Hydrogel-forming wound dressing or skin coating material
US4925677A (en) 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5041292A (en) 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
EP0365705A1 (de) 1988-10-26 1990-05-02 Zentralna Problemna Laboratoria Po Kryobiologia I Lyophilisazia Biopräparat zur Behandlung von Wunden
US5126141A (en) 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5135751A (en) 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5614587A (en) 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US4891359A (en) 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
US4948575A (en) 1989-01-24 1990-08-14 Minnesota Mining And Manufacturing Company Alginate hydrogel foam wound dressing
DE3903672C1 (https=) 1989-02-08 1990-02-01 Lohmann Gmbh & Co Kg
US5062834A (en) 1989-02-24 1991-11-05 Product Development (S.G.Z.) Ltd Device for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate
DK223389D0 (da) 1989-05-05 1989-05-05 Ferrosan As Saarsvamp
US5356883A (en) 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
JPH05501814A (ja) 1989-08-10 1993-04-08 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド 組織接着剤成分の医療用送り出しシステム
US5196185A (en) 1989-09-11 1993-03-23 Micro-Collagen Pharmaceutics, Ltd. Collagen-based wound dressing and method for applying same
FR2652573B1 (fr) 1989-10-03 1991-12-13 Atochem Procede de fabrication du 1,1,1-chlorodifluoroethane.
US5061274A (en) 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5350581A (en) 1989-12-14 1994-09-27 Pharmetrix Corporation Method for manufacturing transdermal devices
US5281528A (en) 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
US5219328A (en) 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5134229A (en) 1990-01-12 1992-07-28 Johnson & Johnson Medical, Inc. Process for preparing a neutralized oxidized cellulose product and its method of use
US4982769A (en) 1990-02-21 1991-01-08 Survival Technology, Inc. Package
JPH0813750B2 (ja) 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5306501A (en) 1990-05-01 1994-04-26 Mediventures, Inc. Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers
CA2016870C (en) * 1990-05-15 1994-03-29 Arnie Drudik Dispenser for storing and mixing several components
US5595735A (en) 1990-05-23 1997-01-21 Johnson & Johnson Medical, Inc. Hemostatic thrombin paste composition
US5634943A (en) 1990-07-12 1997-06-03 University Of Miami Injectable polyethylene oxide gel implant and method for production
US5209776A (en) 1990-07-27 1993-05-11 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5292362A (en) 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5108421A (en) 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5192300A (en) 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
EP0478827B1 (de) 1990-10-04 1994-04-06 Kallies Import-Export Vertrieb Gmbh Stabilisiertes Thrombin, seine Herstellung und seine Verwendung als Thrombinzeitreagens
ZA918168B (en) 1990-10-16 1993-04-14 Takeda Chemical Industries Ltd Prolonged release preparation and polymers thereof.
US5129882A (en) 1990-12-27 1992-07-14 Novoste Corporation Wound clotting device and method of using same
US6391343B1 (en) 1991-01-15 2002-05-21 Hemosphere, Inc. Fibrinogen-coated particles for therapeutic use
US5749895A (en) 1991-02-13 1998-05-12 Fusion Medical Technologies, Inc. Method for bonding or fusion of biological tissue and material
JPH06505656A (ja) 1991-02-13 1994-06-30 フュージョン メデイカル テクノロジーズ インコーポレーテッド 組織溶接用充填剤材料
US5669934A (en) 1991-02-13 1997-09-23 Fusion Medical Technologies, Inc. Methods for joining tissue by applying radiofrequency energy to performed collagen films and sheets
US5690675A (en) 1991-02-13 1997-11-25 Fusion Medical Technologies, Inc. Methods for sealing of staples and other fasteners in tissue
DK0525132T3 (da) 1991-02-14 1996-02-05 Baxter Int Binding af genkendende stoffer til liposomer
US5605938A (en) 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
DE4119140C2 (de) 1991-06-11 1994-05-11 Merz & Co Gmbh & Co Poröser, in Körperflüssigkeiten und Sekreten löslicher, spongoider Formkörper, dessen Herstellung und Verwendung
CA2089487A1 (en) 1991-06-14 1992-12-15 Suk-Zu Song Collagen film drug delivery for proteins
NL9101051A (nl) 1991-06-18 1993-01-18 Ashridge Ag Sluitinrichting voor een bloedvat of dergelijke.
FR2679772B1 (fr) 1991-08-02 1995-05-19 Peters Sa Emboles en particules non resorbables enrobees de materiau hemostatique.
IT1251151B (it) 1991-08-05 1995-05-04 Fidia Spa Materiale spugnoso essenzialmente costituito da acido ialuronico,o suoi derivati
US6620436B1 (en) 1991-10-09 2003-09-16 Lectec Corporation Mixing and dispensing package for a wound dressing
JPH07500035A (ja) 1991-10-09 1995-01-05 レクテック コーポレイション 水性ゲル傷用包帯剤およびパッケージ
WO1993006855A1 (en) 1991-10-11 1993-04-15 Novo Nordisk A/S Hemostatic composition for local hemostasis
AT398079B (de) 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
AU671965B2 (en) 1991-12-05 1996-09-19 Alfatec-Pharma Gmbh Pharmaceutically Applicable Nanosol and Process for Preparing The Same
US5204382A (en) 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
ES2152248T3 (es) 1992-02-28 2001-02-01 Collagen Corp Composiciones de colageno de alta concentracion.
US5468505A (en) 1992-02-28 1995-11-21 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
DE69331096T2 (de) 1992-02-28 2002-08-14 Cohesion Technologies, Inc. Injektierbare, keramische verbindungen sowie verfahren zur deren herstellung und anwendung
US5384333A (en) 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
GB9206509D0 (en) 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges containing active agents
GB2266239B (en) 1992-03-25 1996-03-06 Jevco Ltd Wound healing compositions containing chondroitin sulphate oligosaccharides
EP0637226A4 (en) 1992-04-23 1995-06-14 Scimed Life Systems Inc DEVICE AND METHOD FOR CLOSING VASCULAR POINTS.
IL105529A0 (en) 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
JPH05308969A (ja) 1992-05-13 1993-11-22 Japan Vilene Co Ltd 酵素保持体及びその製造方法
AU4406793A (en) 1992-06-04 1993-12-30 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5547376A (en) 1992-06-18 1996-08-20 Harrel; Stephen K. Methods and apparatus for containing and recovering abrasive powders from an abrasive polisher
US5385606A (en) 1992-07-06 1995-01-31 Kowanko; Nicholas Adhesive composition and method
US5413571A (en) 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
US5443481A (en) 1992-07-27 1995-08-22 Lee; Benjamin I. Methods and device for percutaneous sealing of arterial puncture sites
US5428022A (en) 1992-07-29 1995-06-27 Collagen Corporation Composition of low type III content human placental collagen
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
DE4227681C2 (de) 1992-08-21 1995-05-18 Becker & Co Naturinwerk Wundabdeckungsmaterial auf der Basis von Kollagenfasern und Verfahren zu seiner Herstellung
WO1994006460A1 (en) 1992-09-21 1994-03-31 Vitaphore Corporation Embolization plugs for blood vessels
SK51695A3 (en) 1992-10-19 1995-11-08 Dura Pharma Inc Dry powder medicament inhaler
WO1994010913A1 (en) 1992-11-12 1994-05-26 Neville Alleyne Cardiac protection device
US5334216A (en) 1992-12-10 1994-08-02 Howmedica Inc. Hemostatic plug
US5667839A (en) 1993-01-28 1997-09-16 Collagen Corporation Human recombinant collagen in the milk of transgenic animals
IT1263144B (it) 1993-02-04 1996-08-01 Lanfranco Callegaro Composizioni farmaceutiche comprendenti materiale spugnoso costituito da derivati esterei dell'acido ialuronico in associazione con altre sostanze farmacologicamente attive
JPH08131B2 (ja) 1993-03-05 1996-01-10 新田ゼラチン株式会社 止血用パッド
DE69429337T3 (de) 1993-04-02 2012-08-30 Anticancer Inc. Verfahren zur verabreichung von förderlichen zusammensetzungen auf die haarfollikel
US5951531A (en) 1993-04-20 1999-09-14 Medchem Products, Inc. Apparatus and method for applying a particulate hemostatic agent to living tissue
US5723308A (en) 1993-05-14 1998-03-03 Minnesota Mining And Manufacturing Company Culture medium for rapid count of coliform bacteria
US5951583A (en) 1993-05-25 1999-09-14 Vascular Solutions, Inc. Thrombin and collagen procoagulant and process for making the same
EP0702959B1 (en) 1993-05-31 2001-08-08 Kaken Pharmaceutical Co., Ltd. Cross-linked gelatin gel preparation containing basic fibroblast growth factor
US5387208A (en) 1993-07-26 1995-02-07 The Procter & Gamble Co. Absorbent core having improved dry/wet integrity
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US6861046B1 (en) 1993-08-18 2005-03-01 Dow Corning France Device for dispensing a therapeutic or cosmetic substance onto the skin and a method of skin treatment
US5394886A (en) 1993-09-20 1995-03-07 Nabai; Hossein Skin biopsy plug and method
JPH0790241A (ja) 1993-09-22 1995-04-04 Menicon Co Ltd 眼用レンズ材料用仮接着剤
CA2175203A1 (en) 1993-11-03 1995-05-11 Thaddeus P. Pruss Hemostatic patch
WO1995018216A1 (en) 1993-12-30 1995-07-06 Nitta Gelatin Inc. Process for embedding culture of animal cells
FR2715309B1 (fr) 1994-01-24 1996-08-02 Imedex Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé.
US5441491A (en) 1994-02-04 1995-08-15 Verschoor; Jacob Method and composition for treating biopsy wounds
DE4407875C2 (de) 1994-03-04 1996-04-04 Ankerpharm Gmbh Ankerwerk Rudo Medizinischer Schwamm aus biologisch resorbierbaren Materialien, Verfahren und Vorrichtung zu dessen Herstellung
CA2162997A1 (en) 1994-03-18 1995-09-28 Daphne C. Tse Topical fibrinogen complex
ITPD940054A1 (it) 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
US5674275A (en) 1994-04-06 1997-10-07 Graphic Controls Corporation Polyacrylate and polymethacrylate ester based hydrogel adhesives
US5531759A (en) 1994-04-29 1996-07-02 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
CA2146090C (en) 1994-05-10 1998-11-24 Mark E. Mitchell Apparatus and method of mixing materials in a sterile environment
US5658592A (en) 1994-05-13 1997-08-19 Kuraray Co., Ltd. Medical crosslinked polymer gel of carboxylic polysaccharide and diaminoalkane
JP3107726B2 (ja) 1994-05-13 2000-11-13 株式会社クラレ 水膨潤性高分子ゲル
WO1995031955A2 (en) 1994-05-23 1995-11-30 The Liposome Company, Inc. Formulation preparation device
US5462860A (en) 1994-06-06 1995-10-31 Minnesota Mining And Manufacturing Company Conditioned culture medium for rapid growth and detection of microbes
GB9415739D0 (en) 1994-07-30 1994-09-21 Scimat Ltd Gel wound dressing
US5599735A (en) 1994-08-01 1997-02-04 Texas Instruments Incorporated Method for doped shallow junction formation using direct gas-phase doping
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5588745A (en) 1994-09-02 1996-12-31 Howmedica Methods and apparatus for mixing bone cement components using an evacuated mixing chamber
US5931165A (en) 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
JP2858087B2 (ja) 1994-09-19 1999-02-17 グンゼ株式会社 組織培養用基材及び組織培養法
AU1287895A (en) 1994-10-03 1996-04-26 Otogen Corporation Differentially biodegradable biomedical implants
FR2726571B1 (fr) 1994-11-03 1997-08-08 Izoret Georges Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique
US5660854A (en) 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
US5804203A (en) 1994-12-21 1998-09-08 Cosmederm Technologies Topical product formulations containing strontium for reducing skin irritation
ATE244584T1 (de) 1995-01-16 2003-07-15 Baxter Int Selbsttragende flächengebilde aus vernetztem fibrin zur hemmung von postoperativen adhäsionen
US6146587A (en) 1995-03-06 2000-11-14 Morgan; David M. Sanitizing dry spray material and applicator
US5698213A (en) 1995-03-06 1997-12-16 Ethicon, Inc. Hydrogels of absorbable polyoxaesters
US5580923A (en) 1995-03-14 1996-12-03 Collagen Corporation Anti-adhesion films and compositions for medical use
US5876372A (en) 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US5779668A (en) 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration
DE19513666C1 (de) 1995-04-11 1996-11-28 Behringwerke Ag Vorrichtung zum Zusammenführen einer ersten flüssigen und einer zweiten festen oder flüssigen Komponente mittels Unterdruck unter sterilen Bedingungen
JP3799626B2 (ja) 1995-04-25 2006-07-19 有限会社ナイセム 心臓血管修復材及びその製造方法
US5677284A (en) 1995-06-06 1997-10-14 Regen Biologics, Inc. Charged collagen particle-based delivery matrix
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
WO1996040033A1 (en) 1995-06-07 1996-12-19 Clarion Pharmaceuticals Inc. Non-biological patch for hemostasis
DE19521324C1 (de) 1995-06-12 1996-10-31 Immuno Ag Gewebeklebstoff und Verwendung desselben als Hämostyptikum
BG99900A (en) 1995-09-04 1997-03-31 Bildireva Absorbent sponge of haemostatic application and method for its preparation
AU7398196A (en) 1995-10-11 1997-04-30 Fusion Medical Technologies, Inc. Device and method for sealing tissue
WO1997017024A1 (en) 1995-11-07 1997-05-15 Fusion Medical Technologies, Inc. Methods and articles for fusing matrix layers containing non-biologic polymers to tissue
AU7609896A (en) 1995-11-07 1997-05-29 Fusion Medical Technologies, Inc. Methods and articles for fusing polysaccharide-containing matrix layers to tissue
AU7671196A (en) 1995-11-07 1997-05-29 Fusion Medical Technologies, Inc. Methods and articles for fusing matrix layers containing non-collagenous proteins to tissue
US6464111B2 (en) 1995-11-13 2002-10-15 L'oreal Dispenser containing a product and dispensing method
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
WO1997022371A1 (en) 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5748318A (en) 1996-01-23 1998-05-05 Brown University Research Foundation Optical stress generator and detector
EP0885020A1 (en) 1996-02-20 1998-12-23 Cohesion Corporation Tissue sealant compositions and methods of use thereof
US5782917A (en) 1996-02-26 1998-07-21 Sunmed, Inc. Intramedullary bone plug
DK0796623T3 (da) 1996-03-20 2005-08-01 Baxter Ag Farmaceutisk præparat til behandling af blodkoagulationslidelser
CZ318998A3 (cs) 1996-04-04 1999-09-15 Baxter Aktiengesellschaft Hemostatická houba na bázi kolagenu, způsob její přípravy, kryt na ránu a kit k přípravě tohoto krytu
US5948427A (en) 1996-04-25 1999-09-07 Point Medical Corporation Microparticulate surgical adhesive
CA2251129A1 (en) 1996-05-03 1997-11-13 Innogenetics N.V. New medicaments containing gelatin cross-linked with oxidized polysaccharides
JP4024302B2 (ja) 1996-05-17 2007-12-19 クアドラント、 ドラッグ、 デリバリー、 リミテッド 微粒子および創傷治療におけるその用途
FR2749759B1 (fr) 1996-06-17 1999-11-26 Adir Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
US5791352A (en) 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
AR013829A1 (es) 1996-07-12 2001-01-31 Baxter Int Un dispositivo medico para suministrar cantidades volumetricas de un primer y un segundo fluido, bioquimicamente reactivos, y metodo para suministrarfibrina a una superficie con dicho dispositivo
US5902832A (en) 1996-08-20 1999-05-11 Menlo Care, Inc. Method of synthesizing swollen hydrogel for sphincter augmentation
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US7320962B2 (en) 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US6706690B2 (en) 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
CA2211629A1 (en) 1996-09-17 1998-03-17 Bernard Sams Vial connector assembly for a medicament container
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US5795330A (en) 1996-10-10 1998-08-18 Etex Corporation Mixing device
US7341598B2 (en) 1999-01-13 2008-03-11 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US5863496A (en) 1996-11-25 1999-01-26 Prepared Media Laboratory, Inc. Sterile packaging
AU716137B2 (en) 1997-01-16 2000-02-17 Cohesion Corporation Lyophilized collagen-based biomaterials, process of preparation and uses thereof
US5782860A (en) 1997-02-11 1998-07-21 Biointerventional Corporation Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method
US6045570A (en) 1997-02-11 2000-04-04 Biointerventional Corporation Biological sealant mixture and system for use in percutaneous occlusion of puncture sites and tracts in the human body and method
US6193670B1 (en) 1997-02-14 2001-02-27 Tricardia, Llc Hemostatic agent delivery device having built-in pressure sensor
US5905029A (en) 1997-02-19 1999-05-18 Fritz Berthold Method for rapid hygiene testing
AU737252B2 (en) 1997-02-20 2001-08-16 Cook Medical Technologies Llc Coated implantable medical device
FR2759980A1 (fr) 1997-02-25 1998-08-28 Bras Michel Conditionnement de deux substances destinees a etre melangees
US5965377A (en) 1997-03-24 1999-10-12 Baystate Medical Center Method for determining the presence of mutated BRCA protein
US5939259A (en) 1997-04-09 1999-08-17 Schleicher & Schuell, Inc. Methods and devices for collecting and storing clinical samples for genetic analysis
US6117444A (en) 1997-04-10 2000-09-12 Brigham & Women's Hospital Polyethylene glycol/microfibrillar collagen composite serves as a resorbable hemostatic agent
US6716435B1 (en) 1997-04-18 2004-04-06 Ganeden Biotech, Inc. Absorbent product containing absorbent structure and Bacillus coagulans
US20020039594A1 (en) 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
US6458386B1 (en) 1997-06-03 2002-10-01 Innogenetics N.V. Medicaments based on polymers composed of methacrylamide-modified gelatin
US5957166A (en) 1997-06-16 1999-09-28 Fusion Medical Technologies, Inc. Method and apparatus for dispersing fluid into a material
US5908054A (en) 1997-06-16 1999-06-01 Fusion Medical Technologies, Inc. Fluid dispersion and delivery assembly and method
WO1998057678A2 (en) 1997-06-18 1998-12-23 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar collagen
IT1294797B1 (it) 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
US6042262A (en) 1997-07-29 2000-03-28 Stryker Technologies Corportion Apparatus for storing, mixing, and dispensing two-component bone cement
ZA987019B (en) 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
AU742675B2 (en) 1997-08-22 2002-01-10 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronic acid gel, method of its production and medical material containing it
AU9111698A (en) 1997-09-04 1999-03-22 Pharmacia & Upjohn Company A method for the evaluation of antiviral drugs
ATE306935T1 (de) 1997-09-16 2005-11-15 Integra Lifesciences Corp Zusammensetzung zur förderung des wachstums von duralem oder meningealem gewebe enthaltend kollagen
US5997895A (en) 1997-09-16 1999-12-07 Integra Lifesciences Corporation Dural/meningeal repair product using collagen matrix
US6168788B1 (en) 1997-09-26 2001-01-02 Leon Wortham Fibrin glue without fibrinogen and biosealant compositions and methods
GB2329840C (en) 1997-10-03 2007-10-05 Johnson & Johnson Medical Biopolymer sponge tubes
JP4160256B2 (ja) 1997-10-07 2008-10-01 ロセップ ルーソル ホールディングス リミテッド ディスペンシング装置
US6303323B1 (en) 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
JPH11155951A (ja) 1997-12-01 1999-06-15 Kaken Pharmaceut Co Ltd 減圧シリンジおよびその製造方法
GB9727102D0 (en) 1997-12-22 1998-02-25 Andaris Ltd Microparticles and their therapeutic use
JP3483753B2 (ja) 1997-12-29 2004-01-06 タキロン株式会社 生体内分解吸収性可塑性粘着物
US6099952A (en) 1998-02-18 2000-08-08 Xomed Surgical Products, Inc. Medical sponge having mucopolysaccharide coating
JP2002505169A (ja) 1998-03-06 2002-02-19 バクスター・インターナショナル・インコーポレイテッド 組織シーラントアプリケーターのための乱流混合ヘッドおよびそれのためのスプレーヘッド
AUPP223498A0 (en) 1998-03-06 1998-04-02 Southcorp Australia Pty Ltd A container
AU2900599A (en) 1998-03-10 1999-09-27 Baxter International Inc. Thrombin preparation and products and fibrin sealant methods employing same
US6179872B1 (en) 1998-03-17 2001-01-30 Tissue Engineering Biopolymer matt for use in tissue repair and reconstruction
US20020025921A1 (en) 1999-07-26 2002-02-28 Petito George D. Composition and method for growing, protecting, and healing tissues and cells
JP4533531B2 (ja) 1998-04-03 2010-09-01 ビーエム リサーチ エイ/エス 制御放出組成物
US20020061842A1 (en) 1998-04-10 2002-05-23 Octapharma Ag Method for sterilizing a native collagen in liquid medium, sterile native collagen obtained, compositions containing it and uses
US6200328B1 (en) 1998-05-01 2001-03-13 Sub Q, Incorporated Device and method for facilitating hemostasis of a biopsy tract
US6056970A (en) 1998-05-07 2000-05-02 Genzyme Corporation Compositions comprising hemostatic compounds and bioabsorbable polymers
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US6334865B1 (en) 1998-08-04 2002-01-01 Fusion Medical Technologies, Inc. Percutaneous tissue track closure assembly and method
US6613070B2 (en) 1998-08-04 2003-09-02 Baxter International Inc. System and method for sealing vascular penetrations with hemostatic gels
JP2003521270A (ja) 1998-08-04 2003-07-15 フュージョン メディカル テクノロジーズ, インコーポレイテッド 経皮組織路閉塞アセンブリおよび方法
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
AU5671899A (en) 1998-08-10 2000-03-06 Fibrogen, Inc. Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
US20020015724A1 (en) 1998-08-10 2002-02-07 Chunlin Yang Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
CN1335757A (zh) 1998-11-12 2002-02-13 聚合体生物科学公司 可用于快速凝血和止血的止血聚合物
US6110484A (en) 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US6361551B1 (en) 1998-12-11 2002-03-26 C. R. Bard, Inc. Collagen hemostatic fibers
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
US6328229B1 (en) 1998-12-18 2001-12-11 Cohesion Technologies, Inc. Low volume mixing spray head for mixing and dispensing of two reactive fluid components
DE59902496D1 (de) 1998-12-23 2002-10-02 Aventis Behring Gmbh Fibrinklebergranulat und verfahren zu dessen herstellung
US6283933B1 (en) 1998-12-23 2001-09-04 Closure Medical Corporation Applicator for dispensable liquids
US6977231B1 (en) 1999-01-21 2005-12-20 Nipro Corporation Suturable adhesion-preventing membrane
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
KR100730527B1 (ko) 1999-02-19 2007-06-20 덴끼 가가꾸 고교 가부시키가이샤 히알루론산 겔 조성물과 그의 제조방법 및 그것을함유하는 의용 재료
AU780367B2 (en) 1999-04-14 2005-03-17 Ganeden Biotech, Inc. Methods for inhibiting microbial infections associated with sanitary products
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
EP1053758A1 (de) 1999-05-19 2000-11-22 Resorba Chirurgisches Nahtmaterial Franz Hiltner GmbH & Co. Bioabsorbierbares Implantat
US6544541B1 (en) 1999-06-02 2003-04-08 Cardiovascular Solutions, Inc. Devices and compounds for treating arterial restenosis
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
US20020019062A1 (en) 1999-06-18 2002-02-14 Peter Lea Assay devices
EP1212093B1 (en) 1999-08-26 2004-07-07 Ganeden Biotech, Inc. Use of emu oil as a carrier for antifungal, antibacterial and antiviral medications
DK1218437T3 (da) 1999-08-27 2009-10-19 Angiodevice Internat Gmbh Præparater, som danner interpenetrerende polymernetværk, til anvendelse som medicinske tætningsmidler med höj styrke
US6312474B1 (en) 1999-09-15 2001-11-06 Bio-Vascular, Inc. Resorbable implant materials
US6221109B1 (en) 1999-09-15 2001-04-24 Ed. Geistlich Söhne AG fur Chemische Industrie Method of protecting spinal area
WO2001028603A1 (en) 1999-10-15 2001-04-26 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
JP2001199903A (ja) 1999-11-09 2001-07-24 Eizo Mori 核酸含有複合体
AU2351601A (en) * 1999-12-28 2001-07-09 Asger Lau Dalmose Dual chamber syringe with a dual function piston
US20030095993A1 (en) 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
AU2001234623A1 (en) 2000-01-28 2001-08-07 Orthogene, Inc. Gel-infused sponges for tissue repair and augmentation
IT1317832B1 (it) 2000-02-15 2003-07-15 Eurores S R L Procedimento per la preparazione di collagene micronizzato e sueapplicazioni terapeutiche.
CA2399224A1 (en) 2000-02-18 2001-08-23 Regeneration Technologies, Inc. Implantable tissues infused with growth factors and other additives
US7220276B1 (en) 2000-03-06 2007-05-22 Surmodics, Inc. Endovascular graft coatings
KR100808853B1 (ko) 2000-04-04 2008-03-03 린텍 가부시키가이샤 점착력 측정방법 및 장치
CN1114728C (zh) 2000-04-21 2003-07-16 中国石油化工集团公司 止血纤维及其制造方法
EP1149906A1 (en) 2000-04-25 2001-10-31 Pliva, Farmaceutska, Industrija, Dionicko Drustvo Thrombopoietin receptor modulating peptide
ATE425776T1 (de) 2000-04-28 2009-04-15 Fziomed Inc Haemostatische zusammenstellung von polysauren und polyalkylenoxyden und deren verwendungsmethoden
AU2001266926A1 (en) 2000-06-16 2002-01-02 University Of Medicine And Dentistry Of New Jersey Hemostatic compositions, devices and methods
AT412445B (de) 2000-06-20 2005-03-25 Biering Wolfgang Flüssiges collagen-hämostatikum
AT411326B (de) 2000-06-20 2003-12-29 Biering Wolfgang Hämostatische collagen-pellets
WO2002006456A1 (en) 2000-07-13 2002-01-24 Invitrogen Corporation Methods and compositions for rapid protein and peptide extraction and isolation using a lysis matrix
US6554903B1 (en) 2000-07-19 2003-04-29 Nylok Corporation Unitary spray nozzle
US20030032143A1 (en) 2000-07-24 2003-02-13 Neff Thomas B. Collagen type I and type III compositions for use as an adhesive and sealant
CA2416126C (en) 2000-07-28 2011-07-05 Anika Therapeutics, Inc. Bioabsorbable composites of derivatized hyaluronic acid
US6890342B2 (en) 2000-08-02 2005-05-10 Loma Linda University Method and apparatus for closing vascular puncture using hemostatic material
IT1317358B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Derivati cross-linkati dell'acido ialuronico.
CN1455659A (zh) 2000-09-12 2003-11-12 弗吉尼亚州立大学 高压出血的治疗
AU9109201A (en) 2000-09-18 2002-03-26 Organogenesis Inc Methods for treating a patient using a bioengineered flat sheet graft prostheses
US6364519B1 (en) 2000-09-26 2002-04-02 Smith & Nephew, Inc. Bone cement system
US6635272B2 (en) 2000-11-09 2003-10-21 Richard N. Leaderman Wound dressing and drug delivery system
US6458380B1 (en) 2000-11-09 2002-10-01 Richard Leaderman Dressing and preparation delivery system
US20030009194A1 (en) 2000-12-07 2003-01-09 Saker Mark B. Tissue tract sealing device
US20020082620A1 (en) 2000-12-27 2002-06-27 Elaine Lee Bioactive materials for aneurysm repair
US7041868B2 (en) 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
JP4104462B2 (ja) 2001-01-25 2008-06-18 ニコメド ファーマ エイエス コラーゲンスポンジを調製する方法、コラーゲンフォームの一部を抽出するための装置、および伸長したコラーゲンスポンジ
US6733774B2 (en) 2001-01-25 2004-05-11 Nycomed Pharma As Carrier with solid fibrinogen and solid thrombin
US20020164322A1 (en) 2001-01-25 2002-11-07 Alfred Schaufler Suspension comprising fibrinogen, thrombin and alcohol, a method for preparing such a suspension, a method for coating a carrier with such a suspension, a method of drying a coating of a carrier, and a coated collagen sponge
US7052713B2 (en) 2001-02-13 2006-05-30 Nycomed Pharma As Carrier with solid fibrinogen and solid thrombin
CA2438047A1 (en) 2001-02-14 2002-08-22 Hildegard M. Kramer Biocompatible fleece for hemostasis and tissue engineering
US8187625B2 (en) 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
TW526069B (en) * 2001-04-10 2003-04-01 Sod Conseils Rech Applic Injection device
US6685745B2 (en) 2001-05-15 2004-02-03 Scimed Life Systems, Inc. Delivering an agent to a patient's body
BR0102637A (pt) 2001-05-17 2003-02-25 Johnson & Johnson Ind Com Curativo adesivo
US6962715B2 (en) 2001-10-24 2005-11-08 Hewlett-Packard Development Company, L.P. Method and dosage form for dispensing a bioactive substance
US20050271737A1 (en) 2001-06-07 2005-12-08 Chinea Vanessa I Application of a bioactive agent to a substrate
US7371403B2 (en) 2002-06-14 2008-05-13 Providence Health System-Oregon Wound dressing and method for controlling severe, life-threatening bleeding
US6676987B2 (en) 2001-07-02 2004-01-13 Scimed Life Systems, Inc. Coating a medical appliance with a bubble jet printing head
AU2002300450B2 (en) 2001-08-10 2007-04-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen Carrier of Therapeutic Genetic Material, and Method
WO2003024426A1 (en) 2001-09-21 2003-03-27 Egalet A/S Controlled release solid dispersions
US20040234602A1 (en) 2001-09-21 2004-11-25 Gina Fischer Polymer release system
JP4668510B2 (ja) 2001-09-29 2011-04-13 持田製薬株式会社 可撓性容器入り局所止血用医薬組成物
JP4112851B2 (ja) * 2001-11-27 2008-07-02 テルモ株式会社 2室型プレフィルドシリンジ
EP1458425B1 (en) 2001-12-21 2009-11-18 Ferrosan A/S A hemostatic kit, a method of preparing a hemostatic agent and a method of promoting hemostasis
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
JP4152104B2 (ja) * 2001-12-28 2008-09-17 テルモ株式会社 シリンジおよびガスケット
US20060189516A1 (en) 2002-02-19 2006-08-24 Industrial Technology Research Institute Method for producing cross-linked hyaluronic acid-protein bio-composites
JP4474165B2 (ja) 2002-02-20 2010-06-02 株式会社ネクスト21 噴射用薬剤の調製方法
JP4489437B2 (ja) 2002-02-21 2010-06-23 エンセル,インコーポレイテッド 表面コーティングとしての固定化生物活性ヒドロゲルマトリックス
WO2003079985A2 (en) 2002-03-18 2003-10-02 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US20050239675A1 (en) 2002-04-01 2005-10-27 Munzer Makansi Carrier foam to enhance liquid functional performance
WO2003090683A2 (en) 2002-04-26 2003-11-06 Surgical Sealants, Inc. Mixing device for surgical sealants, and method thereof
CA2485268A1 (en) 2002-05-08 2003-11-20 Rheinisch-Westfaelische Technische Hochschule Aachen (Rwth) Resorbable pharmaceutical formulation for the continuous release of thrombin
US7670623B2 (en) 2002-05-31 2010-03-02 Materials Modification, Inc. Hemostatic composition
US20050137512A1 (en) 2003-12-23 2005-06-23 Campbell Todd D. Wound dressing and method for controlling severe, life-threatening bleeding
US20040120993A1 (en) 2002-12-20 2004-06-24 Guanghui Zhang Hemostatic wound dressing and fabric and methods of making and using same
US20040101546A1 (en) 2002-11-26 2004-05-27 Gorman Anne Jessica Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents
CN1684730A (zh) * 2002-09-04 2005-10-19 梅里迪安医学技术公司 药品输送装置
ATE487470T1 (de) 2002-09-11 2010-11-15 Elan Pharma Int Ltd Gel-stabilisierte wirkstoff-zusammensetzungen in nanoteilchengrösse
DE10242984B4 (de) * 2002-09-17 2010-09-23 Sanatis Gmbh Vorrichtung zum Herstellen von Gemischen aus zwei Komponenten
GB2393120A (en) 2002-09-18 2004-03-24 Johnson & Johnson Medical Ltd Compositions for wound treatment
EP1542739B1 (en) 2002-09-26 2008-12-10 Angiotech International Ag Perivascular wraps
US7074425B2 (en) 2002-09-26 2006-07-11 Bonewax, Llc Hemostatic compositions and methods
GB2393655B (en) 2002-09-27 2005-08-24 Johnson & Johnson Medical Ltd Wound treatment device
WO2004028404A2 (en) 2002-09-30 2004-04-08 Fibrogen, Inc. Dry tissue sealant compositions
IL152030A0 (en) 2002-09-30 2003-05-29 Nvr Labs Ltd Neural & Vascular Cohesive biopolymers comprising sulfated polysaccharides and fibrillar proteins and use thereof for tissue repair
GB2393656B (en) 2002-10-01 2005-11-16 Johnson & Johnson Medical Ltd Enzyme-sensitive therapeutic wound dressings
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
ITPD20020271A1 (it) 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
US20040079763A1 (en) 2002-10-29 2004-04-29 Powell Cindy Hagood Duplex storage pouch
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
JP2004147959A (ja) 2002-10-31 2004-05-27 Nipro Corp 2成分混合型プレフィルドシリンジ
US20060121080A1 (en) 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
US7955288B2 (en) 2002-12-11 2011-06-07 Ferrosan Medical Devices A/S Gelatine-based materials as swabs
US7699804B2 (en) * 2003-01-31 2010-04-20 Creare Inc. Fluid ejection system
GB0304716D0 (en) 2003-02-28 2003-04-02 Uws Ventures Ltd Method for producing partially frozen ice-water-air mixtures
US7112713B2 (en) 2003-03-12 2006-09-26 Gelsus Research And Consulting, Inc. Dressing based on the Teorell-Meyer gradient
US20040181183A1 (en) 2003-03-12 2004-09-16 Sceusa Nicholas A. Bandage based on the teorell-meyer gradient
ATE454886T1 (de) 2003-03-26 2010-01-15 Egalet As Matrixzubereitungen für die kontrollierte darreichung von arzneistoffen
US7051654B2 (en) 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
US8834864B2 (en) 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
MXPA05013119A (es) 2003-06-05 2006-03-17 Baxter Int Composiciones para reparar y regenerar duramadre humana.
US20050118238A1 (en) 2003-06-16 2005-06-02 Zhu Yong H. Deployable hemostatic agent
CN1835723B (zh) 2003-06-16 2011-06-22 洛马林达大学医学中心 可展开的多功能止血剂
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
US7927626B2 (en) 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US20060019868A1 (en) 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
KR100588614B1 (ko) 2003-11-10 2006-06-13 주식회사 바이오레인 기포를 포함하는 유착방지제
WO2005049105A2 (en) 2003-11-10 2005-06-02 Angiotech International Ag Medical implants and anti-scarring agents
JP2005169008A (ja) 2003-12-15 2005-06-30 Nipro Corp 生体適合性材料の滅菌方法
US20050136112A1 (en) 2003-12-19 2005-06-23 Pediamed Pharmaceuticals, Inc. Oral medicament delivery system
CA2554994C (en) 2004-01-30 2015-05-19 Ferrosan A/S Haemostatic sprays and compositions
US7109163B2 (en) 2004-01-30 2006-09-19 Ethicon, Inc. Hemostatic compositions and devices
EP1602365A1 (en) 2004-03-03 2005-12-07 Switch Biotech Aktiengesellschaft Pharmaceutical composition for topical use in form of xerogels or films and methods for production
US20050218541A1 (en) 2004-04-02 2005-10-06 Peng Henry T Method of producing interpenetrating polymer network
US20050245905A1 (en) 2004-04-30 2005-11-03 Schmidt Steven P Local drug-delivery system
GB2414021A (en) 2004-05-10 2005-11-16 Johnson & Johnson Medical Ltd Absorbable haemostatic materials
DK1758557T3 (da) 2004-05-11 2011-10-24 Egalet Ltd Kvældbar doseringsform omfattende gellangummi
US7393674B2 (en) 2004-06-22 2008-07-01 Zymogenetics, Inc. Thrombin compositions
US8119160B2 (en) 2004-06-29 2012-02-21 Ethicon, Inc. Hemostatic compositions and devices
US7968085B2 (en) 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
KR20070046093A (ko) 2004-07-09 2007-05-02 훼로산 아크티에 셀스카브 히알루론산을 포함하는 지혈 조성물
US20080091277A1 (en) 2004-08-13 2008-04-17 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
EP1811935B1 (en) 2004-09-28 2016-03-30 Atrium Medical Corporation Heat cured gel and method of making
DK1793872T3 (en) 2004-09-30 2016-07-25 Covalon Tech Inc NON-ADHESIVE ELASTIC GELATIN Matrices
ES2226587B1 (es) 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US20080220053A1 (en) 2004-12-14 2008-09-11 Fidia Advanced Biopolymers S.R.L. Process for the Preparation of Two and Three Dimensional Polymer Scaffolds
JP2006296896A (ja) 2005-04-22 2006-11-02 Tohoku Univ コラーゲン薄膜シート、その製造方法、それを用いた再建方法、および自己組織再生誘導型人工皮膚・粘膜
US20060255053A1 (en) 2005-05-16 2006-11-16 Empire Industrial Corp. Sealable container
CA2611081C (en) 2005-06-03 2016-05-31 Egalet A/S A drug delivery system for delivering active substances dispersed in a dispersion medium
US20060282138A1 (en) 2005-06-10 2006-12-14 Ohshin Mlp Co., Ltd. Exothermic structure that is directly applied to skin
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
JP4520431B2 (ja) * 2005-09-06 2010-08-04 株式会社永谷園 凍結乾燥ブロック状味噌の製造方法
US20070086958A1 (en) 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
WO2007059144A1 (en) 2005-11-15 2007-05-24 Surmodics, Inc. Ultrasonic nozzles for applying two-component coatings
EP1954342B8 (en) 2005-12-02 2013-04-03 Baxa Corporation Automated medical liquid filling system
US20080289624A1 (en) 2005-12-21 2008-11-27 Kidd Iii William Christopher Aerosol Canister Employing a Polymeric Film Having Improved Moisture Barrier Properties
US20070264130A1 (en) 2006-01-27 2007-11-15 Phluid, Inc. Infusion Pumps and Methods for Use
CN104162200B (zh) 2006-02-09 2018-03-27 德卡产品有限公司 外围系统
US9456860B2 (en) 2006-03-14 2016-10-04 Kci Licensing, Inc. Bioresorbable foaming tissue dressing
US20070250007A1 (en) 2006-04-23 2007-10-25 Nilimedix Ltd. Drug Delivery Device With Air Pressure Spring And Safety Valve
US9114194B2 (en) 2006-05-12 2015-08-25 W. L. Gore & Associates, Inc. Immobilized biologically active entities having high biological activity following mechanical manipulation
US8496953B2 (en) 2006-05-12 2013-07-30 W. L. Gore & Associates, Inc. Immobilized biologically active entities having a high degree of biological activity following sterilization
EP2023967B1 (en) 2006-05-12 2017-03-22 W. L. Gore & Associates, Inc. Immobilized biologically active entities having a high degree of biological activity following mecanical manipulation or sterilization
EP2040724B1 (en) 2006-05-18 2011-10-05 Biobalance Llc Biotherapeutic compositions comprising probiotic escherichia coli and metronidazole and uses thereof
MX2008014847A (es) 2006-05-31 2009-04-30 Baxter Int Metodo para crecimiento interno en la celula dirigido y regeneracion controlada de los tejidos en la cirugia espinal.
KR100751046B1 (ko) 2006-07-21 2007-08-21 이가식품(주) 수용성 키토산을 함유하는 당면의 제조방법
TWI436793B (zh) 2006-08-02 2014-05-11 巴克斯特國際公司 快速作用之乾密封膠及其使用和製造方法
NZ574653A (en) 2006-08-04 2012-11-30 Stb Lifesaving Technologies Inc Solid dressing for treating wounded tissue
US20080095830A1 (en) 2006-10-20 2008-04-24 Van Holten Robert W Method for making a dressing
TWI362925B (en) 2006-11-09 2012-05-01 Kci Licensing Inc Method for preparing a bioresorbable dressing comprising bioresorbable microparticles and method for preparing a bioresorbable dressing comprising bioresorbable microspheres
BRPI0718328A2 (pt) 2006-12-15 2011-10-11 Lifebond Ltd composição, curativo hemostático e dispositivo médico para a inserção em um corpo de um ser humano ou de um mamìfero inferior
US20100143447A1 (en) 2006-12-19 2010-06-10 Ferrosan A/S Wound or tissue dressing comprising lactic acid bacteria
WO2008090555A2 (en) 2007-01-22 2008-07-31 Elutex Ltd. Medical devices having a matrix adhered thereof
WO2008127497A2 (en) 2007-02-21 2008-10-23 The Regents Of The University Of California Hemostatic compositions and methods of use
US20080311172A1 (en) 2007-04-25 2008-12-18 Schapira Jay N Programmed-release, nanostructured biological construct
JP5253501B2 (ja) 2007-06-15 2013-07-31 ザイモジェネティクス, インコーポレイテッド 安定化トロンビン組成物
WO2009020612A1 (en) 2007-08-06 2009-02-12 Stb Lifesaving Technologies, Inc. Methods and dressing for sealing internal injuries
US20090087569A1 (en) 2007-09-27 2009-04-02 Fenchem Enterprises Ltd. Methods for Preparing Highly Stable Hyaluronic Acid
ES2662647T3 (es) 2007-10-30 2018-04-09 Baxter International Inc. Uso de una biomatriz de colágeno biofuncional regenerativa para tratar defectos viscerales o parietales
WO2009091683A1 (en) 2008-01-17 2009-07-23 Becton, Dickinson And Company Valve for mixing of substances
CA2716872C (en) 2008-02-29 2015-02-10 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
KR101541702B1 (ko) 2008-03-03 2015-08-04 옴릭스 바이오파머슈티컬스 리미티드 활성 성분을 포함하는 젤라틴 스펀지, 이의 제조 방법 및 용도
CA2716010C (en) 2008-04-03 2019-10-01 Zymogenetics, Inc. Hemostatic microspheres
CN102083412A (zh) 2008-04-25 2011-06-01 杰伊·N·沙皮拉 编程释放的用于刺激组织再生用细胞植入的纳米结构生物构建体
US8940539B2 (en) 2008-05-14 2015-01-27 Biolyph, L.L.C. Reagent preparation and dispensing device and methods for the same
US20100048758A1 (en) 2008-08-22 2010-02-25 Boston Scientific Scimed, Inc. Lubricious coating composition for devices
US8119742B2 (en) 2008-09-28 2012-02-21 Knc Ner Acquisition Sub, Inc. Multi-armed catechol compound blends
DE102009004828B4 (de) 2009-01-13 2010-12-09 Lts Lohmann Therapie-Systeme Ag Injektor mit verdrängbarem Stopfenteil
JP5088342B2 (ja) 2009-03-25 2012-12-05 三菱マテリアル株式会社 多孔質焼結体の製造方法
US20100256671A1 (en) 2009-04-07 2010-10-07 Biomedica Management Corporation Tissue sealant for use in noncompressible hemorrhage
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
HRP20150255T1 (hr) 2009-06-16 2015-05-08 Baxter International Inc. Hemostatiäśna spužva
US8429831B2 (en) 2009-09-04 2013-04-30 Abbott Cardiovascular Systems Inc. Drug-eluting coatings applied to medical devices by spraying and drying to remove solvent
US20110092918A1 (en) 2009-10-19 2011-04-21 Ferrosan A/S Malleable tip for applying an agent to a target site
WO2011083154A1 (en) 2010-01-08 2011-07-14 Profibrix Bv Dry powder fibrin sealant
JP2011212182A (ja) 2010-03-31 2011-10-27 Terumo Corp プレフィルドシリンジ
EP2563430A2 (en) * 2010-04-30 2013-03-06 Bayer Pharma Aktiengesellschaft Displacement syringe
AU2011260260B2 (en) 2010-06-01 2015-09-03 Baxter Healthcare S.A. Process for making dry and stable hemostatic compositions
JP5973997B2 (ja) 2010-06-01 2016-08-23 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated 乾燥した安定な止血用組成物を作製するためのプロセス
ES2682302T3 (es) 2010-06-01 2018-09-19 Baxter International Inc Proceso para la producción de composiciones hemostáticas secas y estables
RS59243B1 (sr) 2011-04-27 2019-10-31 Biomup Hemostatski sastavi
KR102143252B1 (ko) 2011-10-11 2020-08-11 백스터 인터내셔널 인코포레이티드 지혈 조성물
WO2013053759A2 (en) 2011-10-11 2013-04-18 Baxter International Inc. Hemostatic compositions
MX346958B (es) 2011-10-11 2017-04-06 Baxter Int Composición hemostatica.
SG11201401878SA (en) 2011-10-27 2014-09-26 Baxter Int Hemostatic compositions
EP2806918B1 (en) * 2012-01-23 2019-10-23 Bee Sight Limited Devices for autoflush syringes
CN104159527B (zh) 2012-03-06 2017-04-12 弗罗桑医疗设备公司 包含止血糊剂的压力容器
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
US8992469B2 (en) * 2012-06-26 2015-03-31 Glucago Llc Reconstitution device
CA2893064C (en) 2012-12-07 2021-05-04 Baxter International Inc. Hemostatic foam
JP6390873B2 (ja) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー/エス 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ
BR112016013322B1 (pt) 2013-12-11 2020-07-21 Ferrosan Medical Devices A/S métodos para preparação de uma composição seca e para reconstituir uma composição seca, composição seca, uso de uma composição seca, e, kit
BR112017007466B1 (pt) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca
CA2986981A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
IL242984A0 (en) 2015-12-08 2016-02-29 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, their preparation and how to use them

Also Published As

Publication number Publication date
AU2015371184A1 (en) 2017-07-13
US20180264194A1 (en) 2018-09-20
EP3237041B1 (en) 2020-01-29
RU2017126046A (ru) 2019-01-25
HK1243365A1 (zh) 2018-07-13
JP2018503425A (ja) 2018-02-08
CN107206165B (zh) 2020-10-23
WO2016102446A1 (en) 2016-06-30
BR112017013565A2 (pt) 2018-03-06
AU2015371184B2 (en) 2020-06-25
EP3237041A1 (en) 2017-11-01
RU2705905C2 (ru) 2019-11-12
CN107206165A (zh) 2017-09-26
CA2970710A1 (en) 2016-06-30
JP6747650B2 (ja) 2020-08-26
US10653837B2 (en) 2020-05-19
RU2017126046A3 (https=) 2019-05-23

Similar Documents

Publication Publication Date Title
BR112017013565B1 (pt) Seringa para retenção e mistura de primeira e segunda substâncias
US5779356A (en) Apparatus and method for mixing first and second components of a bone cement in a vacuum
JP6747651B2 (ja) 保管状態で真空を保持するための、及び2種の成分を混合するためのシリンジ
CN101180013B (zh) 用于存储和交付两相合成物的药筒
JP3803934B2 (ja) 凍結乾燥、液体状に戻すことおよび投与のための注射器筒
JP6877503B2 (ja) 骨セメントの提供のためのデバイス
US3380451A (en) Two compartment syringe
US10596069B2 (en) Syringes with mixing chamber in a removable cap
CN115737437A (zh) 压力调节流体输送系统和方法
JP2017064398A (ja) 骨セメントを貯蔵および混合するための装置および方法
TW201210580A (en) Device for sealing a vessel and method of manufacturing a sealed vessel
US20100114067A1 (en) Multi-Chamber Mixing System
JP2021528133A (ja) 医薬製品調製デバイス及び方法
BRPI0820317B1 (pt) Método e dispositivo para a ejeção em série de dois fluidos compreendendo um separador
KR20070100295A (ko) 용기 닫힘 전달 시스템
HK1243365B (en) Syringe for retaining and mixing first and second substances
RU2704016C2 (ru) Система и способ для подготовки инъекции
EA046517B1 (ru) Вакцина для применения в профилактике и/или лечении заболевания

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/12/2015, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 10A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2860 DE 28-10-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.