BR112016027912A2 - molécula de ligação triespecífica capaz de se ligar de maneira imunoespecífica a três epítopos diferentes, composição farmacêutica, método de tratamento de câncer, método de tratamento de uma doença associada à presença de um patógeno, anticorpo anti-ror1, ou fragmento de ligação a ror1, fragmento de anticorpo biespecífico, bite ou anticorpo de cadeia simples, e método de tratamento de câncer - Google Patents

molécula de ligação triespecífica capaz de se ligar de maneira imunoespecífica a três epítopos diferentes, composição farmacêutica, método de tratamento de câncer, método de tratamento de uma doença associada à presença de um patógeno, anticorpo anti-ror1, ou fragmento de ligação a ror1, fragmento de anticorpo biespecífico, bite ou anticorpo de cadeia simples, e método de tratamento de câncer

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Publication number
BR112016027912A2
BR112016027912A2 BR112016027912-3A BR112016027912A BR112016027912A2 BR 112016027912 A2 BR112016027912 A2 BR 112016027912A2 BR 112016027912 A BR112016027912 A BR 112016027912A BR 112016027912 A2 BR112016027912 A2 BR 112016027912A2
Authority
BR
Brazil
Prior art keywords
binding
ror1
cancer treatment
treatment method
antibody
Prior art date
Application number
BR112016027912-3A
Other languages
English (en)
Portuguese (pt)
Inventor
S. Johnson Leslie
Huang Ling
Reddy Chichili Gurunadh
Shah Kalpana
Kao Lam Chia-Ying
James BURKE Stephen
Liu Liqin
A. Moore Paul
Bonvini Ezio
Barat Bhaswati
Original Assignee
Macrogenics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54699839&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016027912(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Macrogenics, Inc. filed Critical Macrogenics, Inc.
Publication of BR112016027912A2 publication Critical patent/BR112016027912A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A—HUMAN NECESSITIES
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Gastroenterology & Hepatology (AREA)
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  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
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BR112016027912-3A 2014-05-29 2015-05-29 molécula de ligação triespecífica capaz de se ligar de maneira imunoespecífica a três epítopos diferentes, composição farmacêutica, método de tratamento de câncer, método de tratamento de uma doença associada à presença de um patógeno, anticorpo anti-ror1, ou fragmento de ligação a ror1, fragmento de anticorpo biespecífico, bite ou anticorpo de cadeia simples, e método de tratamento de câncer BR112016027912A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462004571P 2014-05-29 2014-05-29
US62/004,571 2014-05-29
US201462008229P 2014-06-05 2014-06-05
US62/008,229 2014-06-05
US201562107824P 2015-01-26 2015-01-26
US62/107,824 2015-01-26
PCT/US2015/033076 WO2015184203A1 (en) 2014-05-29 2015-05-29 Tri-specific binding molecules and methods of use thereof

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BR112016027912A2 true BR112016027912A2 (pt) 2018-02-20

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BR112016027912-3A BR112016027912A2 (pt) 2014-05-29 2015-05-29 molécula de ligação triespecífica capaz de se ligar de maneira imunoespecífica a três epítopos diferentes, composição farmacêutica, método de tratamento de câncer, método de tratamento de uma doença associada à presença de um patógeno, anticorpo anti-ror1, ou fragmento de ligação a ror1, fragmento de anticorpo biespecífico, bite ou anticorpo de cadeia simples, e método de tratamento de câncer
BR112016027893A BR112016027893A2 (pt) 2014-05-29 2015-05-29 molécula de ligação triespecífica, e, composição farmacêutica

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US (6) US10647768B2 (https=)
EP (3) EP3148580B1 (https=)
JP (5) JP6647222B2 (https=)
KR (3) KR102364383B1 (https=)
CN (4) CN106414497B (https=)
AP (1) AP2016009586A0 (https=)
AU (4) AU2015266797C1 (https=)
BR (2) BR112016027912A2 (https=)
CA (2) CA2950008C (https=)
CL (2) CL2016003040A1 (https=)
EA (1) EA035419B9 (https=)
ES (2) ES2890079T3 (https=)
IL (2) IL249266B (https=)
MA (1) MA40069A (https=)
MX (3) MX384781B (https=)
NZ (2) NZ726520A (https=)
PE (2) PE20170765A1 (https=)
PH (2) PH12016502370A1 (https=)
PL (2) PL3152235T3 (https=)
RU (2) RU2718692C2 (https=)
SG (4) SG11201609917PA (https=)
TN (1) TN2016000525A1 (https=)
TW (5) TWI718098B (https=)
WO (2) WO2015184207A1 (https=)
ZA (1) ZA201607995B (https=)

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US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
KR102211837B1 (ko) 2013-01-14 2021-02-03 젠코어 인코포레이티드 신규한 이형이량체 단백질
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
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