AU2018207402B2 - Bicyclic inhibitors of histone deacetylase - Google Patents

Bicyclic inhibitors of histone deacetylase Download PDF

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Publication number
AU2018207402B2
AU2018207402B2 AU2018207402A AU2018207402A AU2018207402B2 AU 2018207402 B2 AU2018207402 B2 AU 2018207402B2 AU 2018207402 A AU2018207402 A AU 2018207402A AU 2018207402 A AU2018207402 A AU 2018207402A AU 2018207402 B2 AU2018207402 B2 AU 2018207402B2
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Prior art keywords
disease
disorder
compound
pharmaceutically acceptable
dementia
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AU2018207402A
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AU2018207402A1 (en
Inventor
Nathan Oliver Fuller
John A. Lowe Iii
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Alkermes Inc
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Alkermes Inc
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Assigned to ALKERMES, INC. reassignment ALKERMES, INC. Request for Assignment Assignors: RODIN THERAPEUTICS, INC.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2018207402A 2017-01-11 2018-01-11 Bicyclic inhibitors of histone deacetylase Ceased AU2018207402B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762445022P 2017-01-11 2017-01-11
US62/445,022 2017-01-11
US201762555298P 2017-09-07 2017-09-07
US62/555,298 2017-09-07
PCT/US2018/013260 WO2018132531A1 (en) 2017-01-11 2018-01-11 Bicyclic inhibitors of histone deacetylase

Publications (2)

Publication Number Publication Date
AU2018207402A1 AU2018207402A1 (en) 2019-07-18
AU2018207402B2 true AU2018207402B2 (en) 2023-09-28

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Application Number Title Priority Date Filing Date
AU2018207402A Ceased AU2018207402B2 (en) 2017-01-11 2018-01-11 Bicyclic inhibitors of histone deacetylase

Country Status (27)

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US (7) US10793567B2 (enExample)
EP (2) EP3568135B1 (enExample)
JP (1) JP6756925B2 (enExample)
KR (1) KR102526032B1 (enExample)
CN (1) CN110290789B (enExample)
AU (1) AU2018207402B2 (enExample)
BR (1) BR112019014235A2 (enExample)
CA (1) CA3049443A1 (enExample)
CY (1) CY1125287T1 (enExample)
DK (1) DK3570834T3 (enExample)
ES (2) ES2875562T3 (enExample)
HR (1) HRP20220223T1 (enExample)
HU (1) HUE057849T2 (enExample)
IL (1) IL267953B2 (enExample)
LT (1) LT3570834T (enExample)
MA (1) MA47305A (enExample)
MD (1) MD3570834T2 (enExample)
MX (1) MX394242B (enExample)
PL (1) PL3570834T3 (enExample)
PT (1) PT3570834T (enExample)
RS (1) RS62959B1 (enExample)
SG (1) SG11201906164RA (enExample)
SI (1) SI3570834T1 (enExample)
SM (1) SMT202200131T1 (enExample)
TW (1) TWI770104B (enExample)
WO (2) WO2018132533A1 (enExample)
ZA (1) ZA201904459B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2899906T3 (es) 2015-07-06 2022-03-15 Alkermes Inc Inhibidores bicíclicos de histona desacetilasa
EP3319968A1 (en) 2015-07-06 2018-05-16 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
ES2875562T3 (es) 2017-01-11 2021-11-10 Alkermes Inc Inhibidores bicíclicos de histona desacetilasa
US11225475B2 (en) * 2017-08-07 2022-01-18 Alkermes, Inc. Substituted pyridines as inhibitors of histone deacetylase
US20220227700A1 (en) * 2019-06-13 2022-07-21 Dana-Farber Cancer Institute, Inc. Hdac3 catalytic inhibitor development and uses thereof
US20220267323A1 (en) 2019-07-23 2022-08-25 Alkermes, Inc. Synthesis of bicyclic inhibitors of histone deacetylase
CN110734924B (zh) * 2019-10-25 2020-10-23 山东大学第二医院 一种抑郁症检测、治疗和预后靶点及应用
WO2023102162A1 (en) 2021-12-03 2023-06-08 Tango Therapeutics, Inc. Tgonovel hdac inhibitors and therapeutic use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012149540A1 (en) * 2011-04-28 2012-11-01 The Broad Institute Inc Inhibitors of histone deacetylase

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