AU2013246552A1 - Indole and indazole compounds that activate AMPK - Google Patents

Indole and indazole compounds that activate AMPK Download PDF

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Publication number
AU2013246552A1
AU2013246552A1 AU2013246552A AU2013246552A AU2013246552A1 AU 2013246552 A1 AU2013246552 A1 AU 2013246552A1 AU 2013246552 A AU2013246552 A AU 2013246552A AU 2013246552 A AU2013246552 A AU 2013246552A AU 2013246552 A1 AU2013246552 A1 AU 2013246552A1
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Prior art keywords
alkyl
alkoxy
hydroxy
independently
halo
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Inventor
Samit Kumar Bhattacharya
Kimberly O'keefe Cameron
Matthew Scott Dowling
David Christopher EBNER
Dilinie Prasadhini Fernando
Kevin James Filipski
Daniel Wei-Shung Kung
Esther Cheng Yin LEE
Aaron Christopher Smith
Meihua Mike Tu
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Pfizer Inc
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Pfizer Inc
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Cosmetics (AREA)
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
AU2013246552A 2012-04-10 2013-04-01 Indole and indazole compounds that activate AMPK Abandoned AU2013246552A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261622129P 2012-04-10 2012-04-10
US61/622,129 2012-04-10
PCT/IB2013/052604 WO2013153479A2 (en) 2012-04-10 2013-04-01 Indole and indazole compounds that activate ampk

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AU2013246552A1 true AU2013246552A1 (en) 2014-09-25

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AU2013246552A Abandoned AU2013246552A1 (en) 2012-04-10 2013-04-01 Indole and indazole compounds that activate AMPK

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US (2) US8889730B2 (pt)
EP (1) EP2836490B1 (pt)
JP (1) JP6026642B2 (pt)
KR (1) KR20150002782A (pt)
CN (1) CN104245688A (pt)
AP (1) AP2014007983A0 (pt)
AR (1) AR090633A1 (pt)
AU (1) AU2013246552A1 (pt)
CA (1) CA2869692C (pt)
CO (1) CO7091185A2 (pt)
CR (1) CR20140411A (pt)
CU (1) CU20140118A7 (pt)
CY (1) CY1119194T1 (pt)
DK (1) DK2836490T3 (pt)
DO (1) DOP2014000228A (pt)
EA (1) EA028564B1 (pt)
EC (2) ECSP14020545A (pt)
ES (1) ES2637238T3 (pt)
GT (1) GT201400215A (pt)
HK (1) HK1202547A1 (pt)
HR (1) HRP20171028T1 (pt)
HU (1) HUE033096T2 (pt)
IL (1) IL234860A0 (pt)
IN (1) IN2014DN09200A (pt)
LT (1) LT2836490T (pt)
MD (1) MD20140109A2 (pt)
ME (1) ME02729B (pt)
MX (1) MX2014012330A (pt)
NI (1) NI201400121A (pt)
NZ (1) NZ630700A (pt)
PE (1) PE20142294A1 (pt)
PH (1) PH12014502280B1 (pt)
PL (1) PL2836490T3 (pt)
PT (1) PT2836490T (pt)
RS (1) RS56290B1 (pt)
SG (1) SG11201405571SA (pt)
SI (1) SI2836490T1 (pt)
TN (1) TN2014000420A1 (pt)
TW (1) TWI465431B (pt)
UY (1) UY34736A (pt)
WO (2) WO2013153479A2 (pt)
ZA (1) ZA201406792B (pt)

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