ATE386714T1 - Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- (2'-(n,n-dimethylamino)-ethoxy) -2- phenyl -1,7, 7-tri- methyl -bicyclo[2.2.1 heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze - Google Patents

Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- (2'-(n,n-dimethylamino)-ethoxy) -2- phenyl -1,7, 7-tri- methyl -bicyclo[2.2.1 heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze

Info

Publication number
ATE386714T1
ATE386714T1 AT00927613T AT00927613T ATE386714T1 AT E386714 T1 ATE386714 T1 AT E386714T1 AT 00927613 T AT00927613 T AT 00927613T AT 00927613 T AT00927613 T AT 00927613T AT E386714 T1 ATE386714 T1 AT E386714T1
Authority
AT
Austria
Prior art keywords
bicyclo
heptane
dimethylamino
ethoxy
tri
Prior art date
Application number
AT00927613T
Other languages
German (de)
English (en)
Inventor
Gyula Lukacs
Gyula Simig
Tibor Mezei
Zoltan Budai
Marta Porcs-Makkay
Gyoergy Krasznai
Kalman Nagy
Donath Gyoergyi Vereczkeyne
Tibor Szabo
Norbert Nemeth
Janos Szylagyi
Original Assignee
Egis Gyogyszergyar Nyilvanosan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyilvanosan filed Critical Egis Gyogyszergyar Nyilvanosan
Application granted granted Critical
Publication of ATE386714T1 publication Critical patent/ATE386714T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/12—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00927613T 1999-05-11 2000-05-10 Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- (2'-(n,n-dimethylamino)-ethoxy) -2- phenyl -1,7, 7-tri- methyl -bicyclo[2.2.1 heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze ATE386714T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9901559A HU227114B1 (en) 1999-05-11 1999-05-11 (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same

Publications (1)

Publication Number Publication Date
ATE386714T1 true ATE386714T1 (de) 2008-03-15

Family

ID=89998272

Family Applications (4)

Application Number Title Priority Date Filing Date
AT00927613T ATE386714T1 (de) 1999-05-11 2000-05-10 Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- (2'-(n,n-dimethylamino)-ethoxy) -2- phenyl -1,7, 7-tri- methyl -bicyclo[2.2.1 heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze
AT00110121T ATE237579T1 (de) 1999-05-11 2000-05-10 Hochreine (1r, 2s, 4r)-(-)-2-((2'-(n,n- dimethylamino)-ethoxy))-2-(phenyl)-1,7,7-tri- (methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze, verfahren zu ihrer herstellung sowie sie enthaltendes medikament.
AT00929730T ATE252544T1 (de) 1999-05-11 2000-05-10 Hochreine (1r, 2s, 4r)-(-)-2-((2'-(n,n- dimethylamino)-ethoxy))-2-(phenyl)-1,7,7-tri- (methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze, verfahren zu ihrer herstellung sowie sie enthaltendes medikament.
AT00110122T ATE246170T1 (de) 1999-05-11 2000-05-10 Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- ((2'-(n,n-dimethylamino)-ethoxy))-2-(phenyl)-1, , 7-tri-(methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze

Family Applications After (3)

Application Number Title Priority Date Filing Date
AT00110121T ATE237579T1 (de) 1999-05-11 2000-05-10 Hochreine (1r, 2s, 4r)-(-)-2-((2'-(n,n- dimethylamino)-ethoxy))-2-(phenyl)-1,7,7-tri- (methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze, verfahren zu ihrer herstellung sowie sie enthaltendes medikament.
AT00929730T ATE252544T1 (de) 1999-05-11 2000-05-10 Hochreine (1r, 2s, 4r)-(-)-2-((2'-(n,n- dimethylamino)-ethoxy))-2-(phenyl)-1,7,7-tri- (methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze, verfahren zu ihrer herstellung sowie sie enthaltendes medikament.
AT00110122T ATE246170T1 (de) 1999-05-11 2000-05-10 Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- ((2'-(n,n-dimethylamino)-ethoxy))-2-(phenyl)-1, , 7-tri-(methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze

Country Status (37)

Country Link
US (3) US6335469B1 (enEXAMPLES)
EP (4) EP1177167B1 (enEXAMPLES)
JP (2) JP4031203B2 (enEXAMPLES)
KR (3) KR100581489B1 (enEXAMPLES)
CN (2) CN1325465C (enEXAMPLES)
AR (2) AR023900A1 (enEXAMPLES)
AT (4) ATE386714T1 (enEXAMPLES)
AU (2) AU777737B2 (enEXAMPLES)
BG (2) BG64673B1 (enEXAMPLES)
BR (2) BR0010412A (enEXAMPLES)
CA (2) CA2369393C (enEXAMPLES)
CO (1) CO5170480A1 (enEXAMPLES)
CZ (4) CZ291329B6 (enEXAMPLES)
DE (4) DE60004126T2 (enEXAMPLES)
DK (4) DK1052245T3 (enEXAMPLES)
EA (2) EA002164B1 (enEXAMPLES)
EE (2) EE04638B1 (enEXAMPLES)
ES (4) ES2302694T3 (enEXAMPLES)
FR (2) FR2793490B1 (enEXAMPLES)
HR (2) HRP20000291B1 (enEXAMPLES)
HU (1) HU227114B1 (enEXAMPLES)
IL (4) IL146421A0 (enEXAMPLES)
IS (2) IS6152A (enEXAMPLES)
LT (2) LT4928B (enEXAMPLES)
MX (2) MXPA01011420A (enEXAMPLES)
MY (2) MY122508A (enEXAMPLES)
NO (2) NO321486B1 (enEXAMPLES)
NZ (2) NZ515918A (enEXAMPLES)
PL (2) PL340107A1 (enEXAMPLES)
PT (4) PT1177167E (enEXAMPLES)
SI (4) SI1052245T1 (enEXAMPLES)
SK (4) SK6902000A3 (enEXAMPLES)
TR (2) TR200200147T2 (enEXAMPLES)
TW (2) TW528742B (enEXAMPLES)
UA (2) UA49974C2 (enEXAMPLES)
WO (2) WO2000068181A2 (enEXAMPLES)
ZA (2) ZA200108958B (enEXAMPLES)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227114B1 (en) * 1999-05-11 2010-07-28 Egis Gyogyszergyar Nyilvanosan (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same
US6589996B2 (en) 2000-03-17 2003-07-08 Orion Corporation Treatment of disorders relating to the serotonergic system
US20040082665A1 (en) * 2001-01-22 2004-04-29 Outi Maki-Ikola Method for treating stress or tension
HUP0103017A3 (en) * 2001-07-18 2004-05-28 Egis Gyogyszergyar Nyilvanosan Pharmaceutical composition for the treatment of diseases caused by impairment of cognitive functions and its use
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
HUP0301906A3 (en) * 2003-06-23 2006-03-28 Egis Gyogyszergyar Nyilvanosan Use of bicyclo[2.2.1]heptane derivatives for producing of pharmaceutical compositions having neuroprotectiv activity
WO2005087213A1 (en) * 2004-03-12 2005-09-22 Egis Gyógyszergyár Nyrt. Combination of deramciclane and opoids as analgesics
JP4916680B2 (ja) * 2005-06-30 2012-04-18 株式会社半導体エネルギー研究所 半導体装置の作製方法、剥離方法
US20080258121A1 (en) * 2007-04-23 2008-10-23 Hasan Farooq Fire Retardant Composition
KR20120091196A (ko) 2009-11-19 2012-08-17 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘, 엘티디. 신규 아릴화 캄펜, 이들의 제조방법 및 이의 용도

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179164B (en) * 1979-12-14 1982-08-28 Egyt Gyogyszervegyeszeti Gyar Process for producing cycloalkyl-ethers of alkanolamines
HU212574B (en) * 1990-09-21 1996-08-29 Egyt Gyogyszervegyeszeti Gyar Process for producing (1r,2s)-(-)-2-phenyl-(2'-dimethyl-amino-etoxy)-1,7,7-trimethyl-bicyclo[2.2.1.]heptane
HU214588B (hu) * 1994-07-01 1998-04-28 EGIS Gyógyszergyár Rt. Eljárás bicikloheptán-származékot tartalmazó, CCK-rendszer gátló hatású gyógyászati készítmények előállítására
HU226061B1 (en) 1996-10-17 2008-04-28 Egis Gyogyszergyar Nyilvanosan 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivative, pharmaceutical compositions containing the same and process for their preparation
HUP9900445A2 (hu) * 1999-02-24 2001-06-28 EGIS Gyógyszergyár Rt. Eljárás (1R,2S,4R)-(-)-N,N-(dimetilamino-etoxi)-2-fenil-1,7,7-trimetil-biciklo[2.2.1]heptán előállítására és ennek köztiterméke
HU227114B1 (en) * 1999-05-11 2010-07-28 Egis Gyogyszergyar Nyilvanosan (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same

Also Published As

Publication number Publication date
DK1052243T3 (da) 2003-11-24
IL146421A (en) 2008-11-26
PT1177167E (pt) 2004-03-31
NZ515917A (en) 2004-02-27
BG64442B1 (en) 2005-02-28
EE200100596A (et) 2003-02-17
LT2001108A (en) 2002-03-25
NO20015352L (no) 2002-01-08
US6624201B2 (en) 2003-09-23
EP1052243A3 (en) 2001-02-28
SK285780B6 (sk) 2007-08-02
MXPA01011420A (es) 2002-06-04
LT4928B (lt) 2002-07-25
HU9901559D0 (en) 1999-07-28
DK1177166T3 (da) 2008-06-16
CN1325465C (zh) 2007-07-11
CZ20014051A3 (cs) 2002-05-15
EP1177167B1 (en) 2003-10-22
HU227114B1 (en) 2010-07-28
JP2002544185A (ja) 2002-12-24
SI1052243T1 (en) 2004-02-29
AR023900A1 (es) 2002-09-04
DE60002117T2 (de) 2003-12-24
PT1052243E (pt) 2003-12-31
KR100685071B1 (ko) 2007-02-22
TWI286541B (en) 2007-09-11
DE60006097D1 (de) 2003-11-27
WO2000068181A2 (en) 2000-11-16
CZ20001722A3 (cs) 2000-12-13
JP4031203B2 (ja) 2008-01-09
SK16242001A3 (sk) 2002-04-04
TW528742B (en) 2003-04-21
FR2793490B1 (fr) 2004-04-23
PT1052245E (pt) 2003-09-30
JP4536265B2 (ja) 2010-09-01
DE60006097T2 (de) 2004-06-17
HK1031220A1 (en) 2001-06-08
EP1052245A3 (en) 2001-02-28
EA200000411A2 (ru) 2000-12-25
EP1177167A2 (en) 2002-02-06
US6242386B1 (en) 2001-06-05
ES2194643T3 (es) 2003-12-01
CZ290734B6 (cs) 2002-10-16
EP1052245B1 (en) 2003-04-16
IS6152A (is) 2001-11-09
IL146421A0 (en) 2002-07-25
PT1177166E (pt) 2008-06-02
DE60038112D1 (de) 2008-04-03
ES2302694T3 (es) 2008-08-01
TR200200147T2 (tr) 2002-06-21
BG104416A (en) 2001-03-30
EE04638B1 (et) 2006-06-15
JP2002544184A (ja) 2002-12-24
BG64673B1 (bg) 2005-11-30
CA2369393A1 (en) 2000-11-16
MY122508A (en) 2006-04-29
CO5170480A1 (es) 2002-06-27
DE60004126D1 (de) 2003-09-04
CZ291329B6 (cs) 2003-02-12
HRP20000290B1 (en) 2007-08-31
WO2000068183A3 (en) 2001-07-26
IL146420A (en) 2007-06-03
FR2793489A1 (fr) 2000-11-17
NO321486B1 (no) 2006-05-15
NO20015336D0 (no) 2001-10-31
SI1177167T1 (en) 2004-04-30
KR20060010874A (ko) 2006-02-02
EP1177166B1 (en) 2008-02-20
IS6153A (is) 2001-11-09
SK285635B6 (sk) 2007-05-03
AU4773100A (en) 2000-11-21
EP1052243A2 (en) 2000-11-15
WO2000068181A3 (en) 2001-06-28
EP1177166A2 (en) 2002-02-06
UA61122C2 (uk) 2003-11-17
CN1173928C (zh) 2004-11-03
BR0010412A (pt) 2002-02-13
UA49974C2 (uk) 2002-10-15
NO20015352D0 (no) 2001-11-01
EE200100595A (et) 2003-02-17
NO20015336L (no) 2002-01-08
CZ20001723A3 (cs) 2000-12-13
EE04672B1 (enEXAMPLES) 2006-08-15
EA200000410A3 (ru) 2001-02-26
EA200000411A3 (ru) 2001-02-26
ATE237579T1 (de) 2003-05-15
US6335469B1 (en) 2002-01-01
NZ515918A (en) 2004-02-27
CN1353686A (zh) 2002-06-12
SK16232001A3 (sk) 2002-04-04
NO321487B1 (no) 2006-05-15
IS2570B (is) 2010-01-15
AR020860A1 (es) 2002-05-29
FR2793490A1 (fr) 2000-11-17
DK1052245T3 (da) 2003-08-11
WO2000068183A2 (en) 2000-11-16
CZ20014050A3 (cs) 2002-05-15
ZA200108958B (en) 2002-10-30
TR200200148T2 (tr) 2002-06-21
KR20020010914A (ko) 2002-02-06
EA002163B1 (ru) 2001-12-24
CN1353687A (zh) 2002-06-12
PL340107A1 (en) 2000-11-20
HRP20000290A2 (en) 2005-02-28
AU4600300A (en) 2000-11-21
EP1052245A2 (en) 2000-11-15
HUP9901559A2 (hu) 2002-01-28
ZA200108956B (en) 2003-02-17
AU777737B2 (en) 2004-10-28
AU776696B2 (en) 2004-09-16
DK1177167T3 (da) 2004-03-01
DE60004126T2 (de) 2004-04-22
DE60038112T8 (de) 2009-05-28
SI1052245T1 (en) 2003-10-31
DE60038112T2 (de) 2009-02-12
SI1177166T1 (sl) 2008-08-31
FR2793489B1 (fr) 2004-04-02
PL202956B1 (pl) 2009-08-31
HRP20000291A2 (en) 2001-06-30
LT2001109A (en) 2002-03-25
BG104417A (en) 2001-03-30
LT4927B (lt) 2002-07-25
DE60002117D1 (de) 2003-05-22
PL340108A1 (en) 2000-11-20
EP1052243B1 (en) 2003-07-30
MXPA01011423A (es) 2002-06-04
US20020040164A1 (en) 2002-04-04
KR100581489B1 (ko) 2006-05-22
SK6892000A3 (en) 2000-12-11
ES2208328T3 (es) 2004-06-16
BR0010406A (pt) 2002-02-13
ES2203373T3 (es) 2004-04-16
HK1031372A1 (en) 2001-06-15
HRP20000291B1 (en) 2005-06-30
KR20010112486A (ko) 2001-12-20
ATE246170T1 (de) 2003-08-15
SK6902000A3 (en) 2000-12-11
CA2369393C (en) 2010-07-06
ATE252544T1 (de) 2003-11-15
EA002164B1 (ru) 2001-12-24
MY123523A (en) 2006-05-31
CA2373193A1 (en) 2000-11-16
EA200000410A2 (ru) 2000-12-25
IL146420A0 (en) 2002-07-25

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