NO20015352L - Fremgangsmåte for å fremstille (IR,2S,4R)-(-)-2-[2'-{N,N- dimetylamino}-etoksy]-2-[fenyl]-1,7,7-tri[metyl]-bisyklo[2,2,1]heptan og farmasöytiskakseptable addisjonssalterderav - Google Patents
Fremgangsmåte for å fremstille (IR,2S,4R)-(-)-2-[2'-{N,N- dimetylamino}-etoksy]-2-[fenyl]-1,7,7-tri[metyl]-bisyklo[2,2,1]heptan og farmasöytiskakseptable addisjonssalterderavInfo
- Publication number
- NO20015352L NO20015352L NO20015352A NO20015352A NO20015352L NO 20015352 L NO20015352 L NO 20015352L NO 20015352 A NO20015352 A NO 20015352A NO 20015352 A NO20015352 A NO 20015352A NO 20015352 L NO20015352 L NO 20015352L
- Authority
- NO
- Norway
- Prior art keywords
- biscyclo
- heptane
- dimethylamino
- ethoxy
- tri
- Prior art date
Links
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/12—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9901559A HU227114B1 (en) | 1999-05-11 | 1999-05-11 | (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same |
PCT/HU2000/000043 WO2000068181A2 (en) | 1999-05-11 | 2000-05-10 | Process for preparing (1r,2s,4r) -(-)-2-[(2'- {n,n-dimethylamino} -ethoxy)] -2-[phenyl] -1,7,7-tri- [methyl] -bicyclo [2.2.1] heptane and pharmaceutically acceptable acid addition salts thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20015352D0 NO20015352D0 (no) | 2001-11-01 |
NO20015352L true NO20015352L (no) | 2002-01-08 |
NO321487B1 NO321487B1 (no) | 2006-05-15 |
Family
ID=89998272
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20015336A NO321486B1 (no) | 1999-05-11 | 2001-10-31 | (IR,2S,4R)-(-)-2-[(2'-{N,N-dimetylamino}-etoksy)]-2-[fenyl]-1,7,7-tri-[metyl]-bisyklo[2,2,1]heptan med hoy renhet og farmasoytisk akseptable syreaddisjonssalt derav og en fremgangsmate til fremstilling av disse forbindelser, sa vel som legemidler som inneholder en eller flere av disse forbindelser og deres anvendelser. |
NO20015352A NO321487B1 (no) | 1999-05-11 | 2001-11-01 | Fremgangsmate for a fremstille (IR,2S,4R)-(-)-2-[2'-{N,N-dimetylamino}-etoksy]-2-[fenyl]-1,7,7-tri[metyl]-bisyklo[2,2,1]heptan og farmasoytiskakseptable addisjonssalter derav |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20015336A NO321486B1 (no) | 1999-05-11 | 2001-10-31 | (IR,2S,4R)-(-)-2-[(2'-{N,N-dimetylamino}-etoksy)]-2-[fenyl]-1,7,7-tri-[metyl]-bisyklo[2,2,1]heptan med hoy renhet og farmasoytisk akseptable syreaddisjonssalt derav og en fremgangsmate til fremstilling av disse forbindelser, sa vel som legemidler som inneholder en eller flere av disse forbindelser og deres anvendelser. |
Country Status (38)
Country | Link |
---|---|
US (3) | US6242386B1 (no) |
EP (4) | EP1052245B1 (no) |
JP (2) | JP4031203B2 (no) |
KR (3) | KR100685071B1 (no) |
CN (2) | CN1173928C (no) |
AR (2) | AR023900A1 (no) |
AT (4) | ATE237579T1 (no) |
AU (2) | AU776696B2 (no) |
BG (2) | BG64442B1 (no) |
BR (2) | BR0010412A (no) |
CA (2) | CA2369393C (no) |
CO (1) | CO5170480A1 (no) |
CZ (4) | CZ20014051A3 (no) |
DE (4) | DE60006097T2 (no) |
DK (4) | DK1177166T3 (no) |
EA (2) | EA002163B1 (no) |
EE (2) | EE200100596A (no) |
ES (4) | ES2194643T3 (no) |
FR (2) | FR2793490B1 (no) |
HK (2) | HK1031220A1 (no) |
HR (2) | HRP20000290B1 (no) |
HU (1) | HU227114B1 (no) |
IL (4) | IL146420A0 (no) |
IS (2) | IS2570B (no) |
LT (2) | LT4928B (no) |
MX (2) | MXPA01011423A (no) |
MY (2) | MY123523A (no) |
NO (2) | NO321486B1 (no) |
NZ (2) | NZ515918A (no) |
PL (2) | PL340107A1 (no) |
PT (4) | PT1177166E (no) |
SI (4) | SI1052245T1 (no) |
SK (4) | SK6902000A3 (no) |
TR (2) | TR200200147T2 (no) |
TW (2) | TW528742B (no) |
UA (2) | UA61122C2 (no) |
WO (2) | WO2000068181A2 (no) |
ZA (2) | ZA200108958B (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU227114B1 (en) * | 1999-05-11 | 2010-07-28 | Egis Gyogyszergyar Nyilvanosan | (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same |
US6589996B2 (en) | 2000-03-17 | 2003-07-08 | Orion Corporation | Treatment of disorders relating to the serotonergic system |
US20040082665A1 (en) * | 2001-01-22 | 2004-04-29 | Outi Maki-Ikola | Method for treating stress or tension |
HUP0103017A3 (en) * | 2001-07-18 | 2004-05-28 | Egis Gyogyszergyar Nyilvanosan | Pharmaceutical composition for the treatment of diseases caused by impairment of cognitive functions and its use |
GB0306604D0 (en) * | 2003-03-21 | 2003-04-30 | Curidium Ltd | Second medical use |
HUP0301906A3 (en) * | 2003-06-23 | 2006-03-28 | Egis Gyogyszergyar Nyilvanosan | Use of bicyclo[2.2.1]heptane derivatives for producing of pharmaceutical compositions having neuroprotectiv activity |
AU2004317128A1 (en) * | 2004-03-12 | 2005-09-22 | Egis Gyogyszergyar Nyrt | Combination of deramciclane and opoids as analgesics |
JP4916680B2 (ja) * | 2005-06-30 | 2012-04-18 | 株式会社半導体エネルギー研究所 | 半導体装置の作製方法、剥離方法 |
US20080258121A1 (en) * | 2007-04-23 | 2008-10-23 | Hasan Farooq | Fire Retardant Composition |
RU2578715C2 (ru) | 2009-11-19 | 2016-03-27 | Йиссум Рисерч Дивелопмент Компани Оф Дзе Хебрю Юниверсити Оф Иерусалим, Лтд. | Новые арилированные камфены, способы их получения и их применения |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU179164B (en) * | 1979-12-14 | 1982-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing cycloalkyl-ethers of alkanolamines |
HU212574B (en) * | 1990-09-21 | 1996-08-29 | Egyt Gyogyszervegyeszeti Gyar | Process for producing (1r,2s)-(-)-2-phenyl-(2'-dimethyl-amino-etoxy)-1,7,7-trimethyl-bicyclo[2.2.1.]heptane |
HU214588B (hu) * | 1994-07-01 | 1998-04-28 | EGIS Gyógyszergyár Rt. | Eljárás bicikloheptán-származékot tartalmazó, CCK-rendszer gátló hatású gyógyászati készítmények előállítására |
HU226061B1 (en) | 1996-10-17 | 2008-04-28 | Egis Gyogyszergyar Nyilvanosan | 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivative, pharmaceutical compositions containing the same and process for their preparation |
HUP9900445A2 (hu) * | 1999-02-24 | 2001-06-28 | EGIS Gyógyszergyár Rt. | Eljárás (1R,2S,4R)-(-)-N,N-(dimetilamino-etoxi)-2-fenil-1,7,7-trimetil-biciklo[2.2.1]heptán előállítására és ennek köztiterméke |
HU227114B1 (en) * | 1999-05-11 | 2010-07-28 | Egis Gyogyszergyar Nyilvanosan | (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same |
-
1999
- 1999-05-11 HU HU9901559A patent/HU227114B1/hu not_active IP Right Cessation
-
2000
- 2000-05-10 CN CNB008082391A patent/CN1173928C/zh not_active Expired - Fee Related
- 2000-05-10 HR HR20000290A patent/HRP20000290B1/xx not_active IP Right Cessation
- 2000-05-10 ES ES00110121T patent/ES2194643T3/es not_active Expired - Lifetime
- 2000-05-10 CZ CZ20014051A patent/CZ20014051A3/cs unknown
- 2000-05-10 SI SI200030124T patent/SI1052245T1/xx unknown
- 2000-05-10 DK DK00927613T patent/DK1177166T3/da active
- 2000-05-10 EP EP00110121A patent/EP1052245B1/en not_active Expired - Lifetime
- 2000-05-10 MY MYPI20002032A patent/MY123523A/en unknown
- 2000-05-10 EP EP00110122A patent/EP1052243B1/en not_active Expired - Lifetime
- 2000-05-10 BR BR0010412-4A patent/BR0010412A/pt not_active Application Discontinuation
- 2000-05-10 BG BG104416A patent/BG64442B1/bg unknown
- 2000-05-10 CZ CZ20001722A patent/CZ290734B6/cs not_active IP Right Cessation
- 2000-05-10 KR KR1020017014354A patent/KR100685071B1/ko not_active IP Right Cessation
- 2000-05-10 SI SI200030292T patent/SI1177167T1/xx unknown
- 2000-05-10 EA EA200000410A patent/EA002163B1/ru not_active IP Right Cessation
- 2000-05-10 SK SK690-2000A patent/SK6902000A3/sk unknown
- 2000-05-10 BG BG104417A patent/BG64673B1/bg unknown
- 2000-05-10 AU AU46003/00A patent/AU776696B2/en not_active Ceased
- 2000-05-10 TR TR2002/00147T patent/TR200200147T2/xx unknown
- 2000-05-10 IL IL14642000A patent/IL146420A0/xx active IP Right Grant
- 2000-05-10 AT AT00110121T patent/ATE237579T1/de not_active IP Right Cessation
- 2000-05-10 KR KR1020067001294A patent/KR20060010874A/ko not_active Application Discontinuation
- 2000-05-10 US US09/569,050 patent/US6242386B1/en not_active Expired - Fee Related
- 2000-05-10 EE EEP200100596A patent/EE200100596A/xx not_active IP Right Cessation
- 2000-05-10 PL PL00340107A patent/PL340107A1/xx not_active IP Right Cessation
- 2000-05-10 PT PT00927613T patent/PT1177166E/pt unknown
- 2000-05-10 SK SK1624-2001A patent/SK285780B6/sk not_active IP Right Cessation
- 2000-05-10 DK DK00929730T patent/DK1177167T3/da active
- 2000-05-10 SK SK689-2000A patent/SK6892000A3/sk unknown
- 2000-05-10 PT PT00110121T patent/PT1052245E/pt unknown
- 2000-05-10 IL IL14642100A patent/IL146421A0/xx active IP Right Grant
- 2000-05-10 PL PL340108A patent/PL202956B1/pl not_active IP Right Cessation
- 2000-05-10 DK DK00110121T patent/DK1052245T3/da active
- 2000-05-10 DK DK00110122T patent/DK1052243T3/da active
- 2000-05-10 AR ARP000102239A patent/AR023900A1/es active IP Right Grant
- 2000-05-10 EP EP00927613A patent/EP1177166B1/en not_active Expired - Lifetime
- 2000-05-10 PT PT00929730T patent/PT1177167E/pt unknown
- 2000-05-10 EE EEP200100595A patent/EE04638B1/xx not_active IP Right Cessation
- 2000-05-10 UA UA2000052642A patent/UA61122C2/uk unknown
- 2000-05-10 AU AU47731/00A patent/AU777737B2/en not_active Ceased
- 2000-05-10 ES ES00927613T patent/ES2302694T3/es not_active Expired - Lifetime
- 2000-05-10 SK SK1623-2001A patent/SK285635B6/sk not_active IP Right Cessation
- 2000-05-10 US US09/569,046 patent/US6335469B1/en not_active Expired - Lifetime
- 2000-05-10 CZ CZ20014050A patent/CZ20014050A3/cs unknown
- 2000-05-10 JP JP2000617162A patent/JP4031203B2/ja not_active Expired - Fee Related
- 2000-05-10 CO CO00033730A patent/CO5170480A1/es not_active Application Discontinuation
- 2000-05-10 ES ES00929730T patent/ES2208328T3/es not_active Expired - Lifetime
- 2000-05-10 MY MYPI20002033A patent/MY122508A/en unknown
- 2000-05-10 DE DE60006097T patent/DE60006097T2/de not_active Expired - Lifetime
- 2000-05-10 CA CA2369393A patent/CA2369393C/en not_active Expired - Fee Related
- 2000-05-10 MX MXPA01011423A patent/MXPA01011423A/es active IP Right Grant
- 2000-05-10 ES ES00110122T patent/ES2203373T3/es not_active Expired - Lifetime
- 2000-05-10 HR HR20000291A patent/HRP20000291B1/xx not_active IP Right Cessation
- 2000-05-10 NZ NZ515918A patent/NZ515918A/xx not_active IP Right Cessation
- 2000-05-10 SI SI200030989T patent/SI1177166T1/sl unknown
- 2000-05-10 EP EP00929730A patent/EP1177167B1/en not_active Expired - Lifetime
- 2000-05-10 DE DE60038112T patent/DE60038112T8/de not_active Expired - Fee Related
- 2000-05-10 SI SI200030219T patent/SI1052243T1/xx unknown
- 2000-05-10 MX MXPA01011420A patent/MXPA01011420A/es active IP Right Grant
- 2000-05-10 CA CA002373193A patent/CA2373193A1/en not_active Abandoned
- 2000-05-10 AR ARP000102244A patent/AR020860A1/es not_active Application Discontinuation
- 2000-05-10 KR KR1020017014355A patent/KR100581489B1/ko not_active IP Right Cessation
- 2000-05-10 CZ CZ20001723A patent/CZ291329B6/cs not_active IP Right Cessation
- 2000-05-10 WO PCT/HU2000/000043 patent/WO2000068181A2/en active IP Right Grant
- 2000-05-10 UA UA2000052641A patent/UA49974C2/uk unknown
- 2000-05-10 FR FR0005941A patent/FR2793490B1/fr not_active Expired - Fee Related
- 2000-05-10 CN CNB008083576A patent/CN1325465C/zh not_active Expired - Fee Related
- 2000-05-10 PT PT00110122T patent/PT1052243E/pt unknown
- 2000-05-10 FR FR0005940A patent/FR2793489B1/fr not_active Expired - Fee Related
- 2000-05-10 EA EA200000411A patent/EA002164B1/ru not_active IP Right Cessation
- 2000-05-10 NZ NZ515917A patent/NZ515917A/xx unknown
- 2000-05-10 BR BR0010406-0A patent/BR0010406A/pt not_active Application Discontinuation
- 2000-05-10 AT AT00927613T patent/ATE386714T1/de not_active IP Right Cessation
- 2000-05-10 JP JP2000617164A patent/JP4536265B2/ja not_active Expired - Fee Related
- 2000-05-10 DE DE60004126T patent/DE60004126T2/de not_active Expired - Fee Related
- 2000-05-10 TW TW089108902A patent/TW528742B/zh not_active IP Right Cessation
- 2000-05-10 DE DE60002117T patent/DE60002117T2/de not_active Expired - Lifetime
- 2000-05-10 AT AT00929730T patent/ATE252544T1/de not_active IP Right Cessation
- 2000-05-10 WO PCT/HU2000/000044 patent/WO2000068183A2/en not_active Application Discontinuation
- 2000-05-10 AT AT00110122T patent/ATE246170T1/de not_active IP Right Cessation
- 2000-05-10 TW TW089108901A patent/TWI286541B/zh not_active IP Right Cessation
- 2000-05-10 TR TR2002/00148T patent/TR200200148T2/xx unknown
- 2000-12-14 HK HK00108103A patent/HK1031220A1/xx not_active IP Right Cessation
-
2001
- 2001-01-27 HK HK01100582A patent/HK1031372A1/xx not_active IP Right Cessation
- 2001-10-30 US US09/984,542 patent/US6624201B2/en not_active Expired - Lifetime
- 2001-10-30 ZA ZA200108958A patent/ZA200108958B/en unknown
- 2001-10-30 ZA ZA200108956A patent/ZA200108956B/en unknown
- 2001-10-31 NO NO20015336A patent/NO321486B1/no not_active IP Right Cessation
- 2001-11-01 NO NO20015352A patent/NO321487B1/no unknown
- 2001-11-08 LT LT2001108A patent/LT4928B/lt not_active IP Right Cessation
- 2001-11-08 LT LT2001109A patent/LT4927B/lt not_active IP Right Cessation
- 2001-11-09 IS IS6153A patent/IS2570B/is unknown
- 2001-11-09 IS IS6152A patent/IS6152A/is unknown
- 2001-11-11 IL IL146421A patent/IL146421A/en not_active IP Right Cessation
- 2001-11-11 IL IL146420A patent/IL146420A/en not_active IP Right Cessation
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