BR0010412A - Processo para preparar (1r,2s,4r)-(-)-2-[(2'-{n,n-dimetilamino}-etóxi) ]-2-[fenil]-1,7,7-tri [metil]-biciclo [2.2.1] heptano - Google Patents

Processo para preparar (1r,2s,4r)-(-)-2-[(2'-{n,n-dimetilamino}-etóxi) ]-2-[fenil]-1,7,7-tri [metil]-biciclo [2.2.1] heptano

Info

Publication number
BR0010412A
BR0010412A BR0010412-4A BR0010412A BR0010412A BR 0010412 A BR0010412 A BR 0010412A BR 0010412 A BR0010412 A BR 0010412A BR 0010412 A BR0010412 A BR 0010412A
Authority
BR
Brazil
Prior art keywords
tri
heptane
bicycle
dimethylamino
ethoxy
Prior art date
Application number
BR0010412-4A
Other languages
English (en)
Inventor
Gyula Lukacs
Gyula Simig
Tibor Mezei
Zoltan Budai
Marta Porcs-Makkay
Gy Rgy Krasznai
Kalman Nagy
Gy Rgyi Vereczeyne Donath
Tibor Szabo
Norbert Nemeth
Janos Szulagyi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of BR0010412A publication Critical patent/BR0010412A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/12—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Abstract

"PROCESSO PARA PREPARAR (1R,2S,4R)-(-)-2-[(2'-{N,N-DIMETILAMINO}-ETóXI)]-2-[FENIL]-1,7, 7-TRI [METIL]-BICICLO [2.2.1] HEPTANO". A invenção refere-se a um processo para preparar (1R,2S,4R)-(-)-2-[(2'-{N,N-dimetilamino}-etóxi)]-2-[fenil]-1,7,7-tri [metil]-biciclo [2.2.2] heptano e seus sais de adição de ácido farmaceuticamente aceitáveis com produções mais elevadas e mais elevados graus de pureza.
BR0010412-4A 1999-05-11 2000-05-10 Processo para preparar (1r,2s,4r)-(-)-2-[(2'-{n,n-dimetilamino}-etóxi) ]-2-[fenil]-1,7,7-tri [metil]-biciclo [2.2.1] heptano BR0010412A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9901559A HU227114B1 (en) 1999-05-11 1999-05-11 (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same
PCT/HU2000/000043 WO2000068181A2 (en) 1999-05-11 2000-05-10 Process for preparing (1r,2s,4r) -(-)-2-[(2'- {n,n-dimethylamino} -ethoxy)] -2-[phenyl] -1,7,7-tri- [methyl] -bicyclo [2.2.1] heptane and pharmaceutically acceptable acid addition salts thereof

Publications (1)

Publication Number Publication Date
BR0010412A true BR0010412A (pt) 2002-02-13

Family

ID=89998272

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0010412-4A BR0010412A (pt) 1999-05-11 2000-05-10 Processo para preparar (1r,2s,4r)-(-)-2-[(2'-{n,n-dimetilamino}-etóxi) ]-2-[fenil]-1,7,7-tri [metil]-biciclo [2.2.1] heptano
BR0010406-0A BR0010406A (pt) 1999-05-11 2000-05-10 Composto, processo para preparar um composto, medicamentos e uso de compostos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0010406-0A BR0010406A (pt) 1999-05-11 2000-05-10 Composto, processo para preparar um composto, medicamentos e uso de compostos

Country Status (38)

Country Link
US (3) US6335469B1 (pt)
EP (4) EP1052243B1 (pt)
JP (2) JP4031203B2 (pt)
KR (3) KR100581489B1 (pt)
CN (2) CN1325465C (pt)
AR (2) AR023900A1 (pt)
AT (4) ATE386714T1 (pt)
AU (2) AU777737B2 (pt)
BG (2) BG64442B1 (pt)
BR (2) BR0010412A (pt)
CA (2) CA2373193A1 (pt)
CO (1) CO5170480A1 (pt)
CZ (4) CZ291329B6 (pt)
DE (4) DE60004126T2 (pt)
DK (4) DK1052243T3 (pt)
EA (2) EA002164B1 (pt)
EE (2) EE200100596A (pt)
ES (4) ES2208328T3 (pt)
FR (2) FR2793490B1 (pt)
HK (2) HK1031220A1 (pt)
HR (2) HRP20000290B1 (pt)
HU (1) HU227114B1 (pt)
IL (4) IL146420A0 (pt)
IS (2) IS6152A (pt)
LT (2) LT4928B (pt)
MX (2) MXPA01011420A (pt)
MY (2) MY123523A (pt)
NO (2) NO321486B1 (pt)
NZ (2) NZ515918A (pt)
PL (2) PL202956B1 (pt)
PT (4) PT1177166E (pt)
SI (4) SI1052243T1 (pt)
SK (4) SK6892000A3 (pt)
TR (2) TR200200148T2 (pt)
TW (2) TW528742B (pt)
UA (2) UA49974C2 (pt)
WO (2) WO2000068183A2 (pt)
ZA (2) ZA200108958B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227114B1 (en) 1999-05-11 2010-07-28 Egis Gyogyszergyar Nyilvanosan (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same
US6589996B2 (en) 2000-03-17 2003-07-08 Orion Corporation Treatment of disorders relating to the serotonergic system
US20040082665A1 (en) * 2001-01-22 2004-04-29 Outi Maki-Ikola Method for treating stress or tension
HUP0103017A3 (en) * 2001-07-18 2004-05-28 Egis Gyogyszergyar Nyilvanosan Pharmaceutical composition for the treatment of diseases caused by impairment of cognitive functions and its use
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
HUP0301906A3 (en) * 2003-06-23 2006-03-28 Egis Gyogyszergyar Nyilvanosan Use of bicyclo[2.2.1]heptane derivatives for producing of pharmaceutical compositions having neuroprotectiv activity
US20070244102A1 (en) * 2004-03-12 2007-10-18 Istvan Gacsalyi Combination of Dermaciclane and Opoids as Analgesics
JP4916680B2 (ja) * 2005-06-30 2012-04-18 株式会社半導体エネルギー研究所 半導体装置の作製方法、剥離方法
US20080258121A1 (en) * 2007-04-23 2008-10-23 Hasan Farooq Fire Retardant Composition
UA109414C2 (uk) 2009-11-19 2015-08-25 Їсум Ресьорч Девелопмент Компані Оф Зе Хебрю Юніверсіті Оф Єрусалім, Лтд. Арильовані камфени та фармацевтична композиція на їх основі

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179164B (en) 1979-12-14 1982-08-28 Egyt Gyogyszervegyeszeti Gyar Process for producing cycloalkyl-ethers of alkanolamines
HU212574B (en) * 1990-09-21 1996-08-29 Egyt Gyogyszervegyeszeti Gyar Process for producing (1r,2s)-(-)-2-phenyl-(2'-dimethyl-amino-etoxy)-1,7,7-trimethyl-bicyclo[2.2.1.]heptane
HU214588B (hu) * 1994-07-01 1998-04-28 EGIS Gyógyszergyár Rt. Eljárás bicikloheptán-származékot tartalmazó, CCK-rendszer gátló hatású gyógyászati készítmények előállítására
HU226061B1 (en) 1996-10-17 2008-04-28 Egis Gyogyszergyar Nyilvanosan 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivative, pharmaceutical compositions containing the same and process for their preparation
HUP9900445A2 (hu) * 1999-02-24 2001-06-28 EGIS Gyógyszergyár Rt. Eljárás (1R,2S,4R)-(-)-N,N-(dimetilamino-etoxi)-2-fenil-1,7,7-trimetil-biciklo[2.2.1]heptán előállítására és ennek köztiterméke
HU227114B1 (en) * 1999-05-11 2010-07-28 Egis Gyogyszergyar Nyilvanosan (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same

Also Published As

Publication number Publication date
PT1177166E (pt) 2008-06-02
MXPA01011423A (es) 2002-06-04
EP1052245A2 (en) 2000-11-15
AR023900A1 (es) 2002-09-04
SK16242001A3 (sk) 2002-04-04
AU4600300A (en) 2000-11-21
DK1177166T3 (da) 2008-06-16
EA002164B1 (ru) 2001-12-24
DK1052245T3 (da) 2003-08-11
WO2000068183A3 (en) 2001-07-26
UA49974C2 (uk) 2002-10-15
WO2000068183A2 (en) 2000-11-16
NO321486B1 (no) 2006-05-15
EE04672B1 (pt) 2006-08-15
IS6152A (is) 2001-11-09
TR200200147T2 (tr) 2002-06-21
DE60038112D1 (de) 2008-04-03
AU777737B2 (en) 2004-10-28
LT2001108A (en) 2002-03-25
ATE237579T1 (de) 2003-05-15
DE60038112T2 (de) 2009-02-12
ATE252544T1 (de) 2003-11-15
PL202956B1 (pl) 2009-08-31
HU9901559D0 (en) 1999-07-28
US6335469B1 (en) 2002-01-01
NO321487B1 (no) 2006-05-15
AU776696B2 (en) 2004-09-16
IS6153A (is) 2001-11-09
WO2000068181A2 (en) 2000-11-16
EA200000411A2 (ru) 2000-12-25
DE60038112T8 (de) 2009-05-28
HU227114B1 (en) 2010-07-28
DK1052243T3 (da) 2003-11-24
LT4927B (lt) 2002-07-25
KR20060010874A (ko) 2006-02-02
BG104417A (en) 2001-03-30
DE60004126T2 (de) 2004-04-22
LT2001109A (en) 2002-03-25
PL340107A1 (en) 2000-11-20
HRP20000291B1 (en) 2005-06-30
EA200000411A3 (ru) 2001-02-26
HK1031220A1 (en) 2001-06-08
CN1173928C (zh) 2004-11-03
AU4773100A (en) 2000-11-21
CA2373193A1 (en) 2000-11-16
EA200000410A2 (ru) 2000-12-25
HRP20000291A2 (en) 2001-06-30
FR2793490B1 (fr) 2004-04-23
TWI286541B (en) 2007-09-11
DE60002117T2 (de) 2003-12-24
NZ515917A (en) 2004-02-27
BG104416A (en) 2001-03-30
ES2194643T3 (es) 2003-12-01
DE60006097T2 (de) 2004-06-17
TW528742B (en) 2003-04-21
ATE246170T1 (de) 2003-08-15
SK16232001A3 (sk) 2002-04-04
IL146421A0 (en) 2002-07-25
NZ515918A (en) 2004-02-27
EE200100595A (et) 2003-02-17
TR200200148T2 (tr) 2002-06-21
JP4536265B2 (ja) 2010-09-01
NO20015352L (no) 2002-01-08
AR020860A1 (es) 2002-05-29
NO20015336D0 (no) 2001-10-31
CZ20001722A3 (cs) 2000-12-13
JP2002544184A (ja) 2002-12-24
DE60004126D1 (de) 2003-09-04
PT1052243E (pt) 2003-12-31
UA61122C2 (uk) 2003-11-17
SI1177166T1 (sl) 2008-08-31
FR2793489B1 (fr) 2004-04-02
EP1052243A2 (en) 2000-11-15
EA200000410A3 (ru) 2001-02-26
CA2369393A1 (en) 2000-11-16
EE04638B1 (et) 2006-06-15
CO5170480A1 (es) 2002-06-27
US6242386B1 (en) 2001-06-05
BG64442B1 (en) 2005-02-28
LT4928B (lt) 2002-07-25
CZ20014051A3 (cs) 2002-05-15
EP1177167B1 (en) 2003-10-22
IL146420A0 (en) 2002-07-25
MY122508A (en) 2006-04-29
CZ20001723A3 (cs) 2000-12-13
NO20015352D0 (no) 2001-11-01
US6624201B2 (en) 2003-09-23
EP1052243A3 (en) 2001-02-28
EA002163B1 (ru) 2001-12-24
EP1052245A3 (en) 2001-02-28
HRP20000290B1 (en) 2007-08-31
PT1177167E (pt) 2004-03-31
KR20010112486A (ko) 2001-12-20
US20020040164A1 (en) 2002-04-04
ZA200108956B (en) 2003-02-17
EP1177167A2 (en) 2002-02-06
EP1177166A2 (en) 2002-02-06
ATE386714T1 (de) 2008-03-15
EP1052243B1 (en) 2003-07-30
ZA200108958B (en) 2002-10-30
IS2570B (is) 2010-01-15
KR100685071B1 (ko) 2007-02-22
EP1177166B1 (en) 2008-02-20
NO20015336L (no) 2002-01-08
EE200100596A (et) 2003-02-17
BG64673B1 (bg) 2005-11-30
CZ290734B6 (cs) 2002-10-16
EP1052245B1 (en) 2003-04-16
JP2002544185A (ja) 2002-12-24
SI1052243T1 (en) 2004-02-29
CN1353686A (zh) 2002-06-12
IL146421A (en) 2008-11-26
CN1325465C (zh) 2007-07-11
FR2793490A1 (fr) 2000-11-17
DE60002117D1 (de) 2003-05-22
HUP9901559A2 (hu) 2002-01-28
ES2302694T3 (es) 2008-08-01
CA2369393C (en) 2010-07-06
DE60006097D1 (de) 2003-11-27
KR20020010914A (ko) 2002-02-06
PL340108A1 (en) 2000-11-20
WO2000068181A3 (en) 2001-06-28
JP4031203B2 (ja) 2008-01-09
SI1052245T1 (en) 2003-10-31
ES2208328T3 (es) 2004-06-16
FR2793489A1 (fr) 2000-11-17
CZ20014050A3 (cs) 2002-05-15
MXPA01011420A (es) 2002-06-04
CZ291329B6 (cs) 2003-02-12
SK285635B6 (sk) 2007-05-03
KR100581489B1 (ko) 2006-05-22
SK6892000A3 (en) 2000-12-11
MY123523A (en) 2006-05-31
IL146420A (en) 2007-06-03
PT1052245E (pt) 2003-09-30
SI1177167T1 (en) 2004-04-30
HRP20000290A2 (en) 2005-02-28
SK285780B6 (sk) 2007-08-02
BR0010406A (pt) 2002-02-13
ES2203373T3 (es) 2004-04-16
HK1031372A1 (en) 2001-06-15
SK6902000A3 (en) 2000-12-11
DK1177167T3 (da) 2004-03-01
CN1353687A (zh) 2002-06-12

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM OS ARTIGOS 8O E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.