DE60038112D1 - (2'-(N,N-DIMETHYLAMINO)-ETHOXY) -2-iPHENYL -1,7,7-TRI-iMETHYL -BICYCLOi2.2.1 HEPTAN UND IHRE PHARMAZEUTISCH AKZEPTIERBAREN SÄURE-ADDITIONS-SALZE - Google Patents

(2'-(N,N-DIMETHYLAMINO)-ETHOXY) -2-iPHENYL -1,7,7-TRI-iMETHYL -BICYCLOi2.2.1 HEPTAN UND IHRE PHARMAZEUTISCH AKZEPTIERBAREN SÄURE-ADDITIONS-SALZE

Info

Publication number
DE60038112D1
DE60038112D1 DE60038112T DE60038112T DE60038112D1 DE 60038112 D1 DE60038112 D1 DE 60038112D1 DE 60038112 T DE60038112 T DE 60038112T DE 60038112 T DE60038112 T DE 60038112T DE 60038112 D1 DE60038112 D1 DE 60038112D1
Authority
DE
Germany
Prior art keywords
acarmaceutic
iphenyl
imethyl
heptane
dimethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60038112T
Other languages
English (en)
Other versions
DE60038112T2 (de
DE60038112T8 (de
Inventor
Gyula Lukacs
Gyula Simig
Tibor Mezei
Zoltan Budai
Marta Porcs-Makkay
Gyoergy Krasznai
Kalman Nagy
Donath Gyoergyi Vereczkeyne
Tibor Szabo
Norbert Nemeth
Janos Szylagyi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egis Pharmaceuticals PLC
Original Assignee
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Pharmaceuticals PLC filed Critical Egis Pharmaceuticals PLC
Publication of DE60038112D1 publication Critical patent/DE60038112D1/de
Publication of DE60038112T2 publication Critical patent/DE60038112T2/de
Application granted granted Critical
Publication of DE60038112T8 publication Critical patent/DE60038112T8/de
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/12—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60038112T 1999-05-11 2000-05-10 Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2-[(2'-{n,n-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptan und ihre pharmazeutisch akzeptierbaren säure-additions-salze Expired - Fee Related DE60038112T8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU9901559A HU227114B1 (en) 1999-05-11 1999-05-11 (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same
HU1505999 1999-05-11
PCT/HU2000/000043 WO2000068181A2 (en) 1999-05-11 2000-05-10 Process for preparing (1r,2s,4r) -(-)-2-[(2'- {n,n-dimethylamino} -ethoxy)] -2-[phenyl] -1,7,7-tri- [methyl] -bicyclo [2.2.1] heptane and pharmaceutically acceptable acid addition salts thereof

Publications (3)

Publication Number Publication Date
DE60038112D1 true DE60038112D1 (de) 2008-04-03
DE60038112T2 DE60038112T2 (de) 2009-02-12
DE60038112T8 DE60038112T8 (de) 2009-05-28

Family

ID=89998272

Family Applications (4)

Application Number Title Priority Date Filing Date
DE60002117T Expired - Lifetime DE60002117T2 (de) 1999-05-11 2000-05-10 Hochreine (1R, 2S, 4R)-(-)-2-[(2'-(N,N-dimethylamino)-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptan und ihre pharmazeutisch akzeptierbaren Säure-Additions-Salze, Verfahren zu ihrer Herstellung sowie sie enthaltendes Medikament.
DE60006097T Expired - Lifetime DE60006097T2 (de) 1999-05-11 2000-05-10 Hochreine (1r, 2s, 4r)-(-)-2-[(2'-(n,n-dimethylamino)-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptan und ihre pharmazeutisch akzeptierbaren säure-additions-salze, verfahren zu ihrer herstellung sowie sie enthaltendes medikament.
DE60004126T Expired - Fee Related DE60004126T2 (de) 1999-05-11 2000-05-10 Verfahren zur Herstellung von (1R, 2S, 4R)-(-)-2-[(2'-(N,N-dimethylamino)-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptan und ihre pharmazeutisch akzeptierbaren Säure-Additions-Salze
DE60038112T Expired - Fee Related DE60038112T8 (de) 1999-05-11 2000-05-10 Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2-[(2'-{n,n-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptan und ihre pharmazeutisch akzeptierbaren säure-additions-salze

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE60002117T Expired - Lifetime DE60002117T2 (de) 1999-05-11 2000-05-10 Hochreine (1R, 2S, 4R)-(-)-2-[(2'-(N,N-dimethylamino)-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptan und ihre pharmazeutisch akzeptierbaren Säure-Additions-Salze, Verfahren zu ihrer Herstellung sowie sie enthaltendes Medikament.
DE60006097T Expired - Lifetime DE60006097T2 (de) 1999-05-11 2000-05-10 Hochreine (1r, 2s, 4r)-(-)-2-[(2'-(n,n-dimethylamino)-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptan und ihre pharmazeutisch akzeptierbaren säure-additions-salze, verfahren zu ihrer herstellung sowie sie enthaltendes medikament.
DE60004126T Expired - Fee Related DE60004126T2 (de) 1999-05-11 2000-05-10 Verfahren zur Herstellung von (1R, 2S, 4R)-(-)-2-[(2'-(N,N-dimethylamino)-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptan und ihre pharmazeutisch akzeptierbaren Säure-Additions-Salze

Country Status (38)

Country Link
US (3) US6242386B1 (de)
EP (4) EP1177167B1 (de)
JP (2) JP4536265B2 (de)
KR (3) KR100581489B1 (de)
CN (2) CN1173928C (de)
AR (2) AR020860A1 (de)
AT (4) ATE386714T1 (de)
AU (2) AU777737B2 (de)
BG (2) BG64673B1 (de)
BR (2) BR0010406A (de)
CA (2) CA2373193A1 (de)
CO (1) CO5170480A1 (de)
CZ (4) CZ20014051A3 (de)
DE (4) DE60002117T2 (de)
DK (4) DK1052243T3 (de)
EA (2) EA002163B1 (de)
EE (2) EE200100596A (de)
ES (4) ES2208328T3 (de)
FR (2) FR2793490B1 (de)
HK (2) HK1031220A1 (de)
HR (2) HRP20000290B1 (de)
HU (1) HU227114B1 (de)
IL (4) IL146421A0 (de)
IS (2) IS6152A (de)
LT (2) LT4928B (de)
MX (2) MXPA01011423A (de)
MY (2) MY123523A (de)
NO (2) NO321486B1 (de)
NZ (2) NZ515917A (de)
PL (2) PL202956B1 (de)
PT (4) PT1177166E (de)
SI (4) SI1177167T1 (de)
SK (4) SK285635B6 (de)
TR (2) TR200200148T2 (de)
TW (2) TW528742B (de)
UA (2) UA49974C2 (de)
WO (2) WO2000068183A2 (de)
ZA (2) ZA200108958B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227114B1 (en) * 1999-05-11 2010-07-28 Egis Gyogyszergyar Nyilvanosan (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same
US6589996B2 (en) 2000-03-17 2003-07-08 Orion Corporation Treatment of disorders relating to the serotonergic system
US20040082665A1 (en) * 2001-01-22 2004-04-29 Outi Maki-Ikola Method for treating stress or tension
HUP0103017A3 (en) * 2001-07-18 2004-05-28 Egis Gyogyszergyar Nyilvanosan Pharmaceutical composition for the treatment of diseases caused by impairment of cognitive functions and its use
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
HUP0301906A3 (en) * 2003-06-23 2006-03-28 Egis Gyogyszergyar Nyilvanosan Use of bicyclo[2.2.1]heptane derivatives for producing of pharmaceutical compositions having neuroprotectiv activity
CZ2006623A3 (cs) * 2004-03-12 2007-01-24 Egis Gyogyszergyár Nyrt. Kombinace deramciklanu a opioidů jako analgetik
JP4916680B2 (ja) * 2005-06-30 2012-04-18 株式会社半導体エネルギー研究所 半導体装置の作製方法、剥離方法
US20080258121A1 (en) * 2007-04-23 2008-10-23 Hasan Farooq Fire Retardant Composition
MX2012005634A (es) 2009-11-19 2012-09-07 Yissum Res Dev Co Canfenos arilados novedosos, procesos para su preparacion y usos.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179164B (en) * 1979-12-14 1982-08-28 Egyt Gyogyszervegyeszeti Gyar Process for producing cycloalkyl-ethers of alkanolamines
HU212574B (en) * 1990-09-21 1996-08-29 Egyt Gyogyszervegyeszeti Gyar Process for producing (1r,2s)-(-)-2-phenyl-(2'-dimethyl-amino-etoxy)-1,7,7-trimethyl-bicyclo[2.2.1.]heptane
HU214588B (hu) * 1994-07-01 1998-04-28 EGIS Gyógyszergyár Rt. Eljárás bicikloheptán-származékot tartalmazó, CCK-rendszer gátló hatású gyógyászati készítmények előállítására
HU226061B1 (en) 1996-10-17 2008-04-28 Egis Gyogyszergyar Nyilvanosan 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivative, pharmaceutical compositions containing the same and process for their preparation
HUP9900445A2 (hu) * 1999-02-24 2001-06-28 EGIS Gyógyszergyár Rt. Eljárás (1R,2S,4R)-(-)-N,N-(dimetilamino-etoxi)-2-fenil-1,7,7-trimetil-biciklo[2.2.1]heptán előállítására és ennek köztiterméke
HU227114B1 (en) * 1999-05-11 2010-07-28 Egis Gyogyszergyar Nyilvanosan (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same

Also Published As

Publication number Publication date
PT1052243E (pt) 2003-12-31
BR0010406A (pt) 2002-02-13
SK16232001A3 (sk) 2002-04-04
BG64442B1 (en) 2005-02-28
WO2000068181A3 (en) 2001-06-28
WO2000068181A2 (en) 2000-11-16
SI1177167T1 (en) 2004-04-30
DK1052243T3 (da) 2003-11-24
DE60038112T2 (de) 2009-02-12
CZ20001723A3 (cs) 2000-12-13
SK16242001A3 (sk) 2002-04-04
CZ20014051A3 (cs) 2002-05-15
EP1177167B1 (de) 2003-10-22
CZ290734B6 (cs) 2002-10-16
EP1052243A2 (de) 2000-11-15
US6335469B1 (en) 2002-01-01
EA002163B1 (ru) 2001-12-24
US20020040164A1 (en) 2002-04-04
LT4928B (lt) 2002-07-25
ES2194643T3 (es) 2003-12-01
SK6902000A3 (en) 2000-12-11
AR020860A1 (es) 2002-05-29
HU227114B1 (en) 2010-07-28
ES2203373T3 (es) 2004-04-16
HK1031372A1 (en) 2001-06-15
KR20020010914A (ko) 2002-02-06
PL340108A1 (en) 2000-11-20
DE60006097D1 (de) 2003-11-27
NO321486B1 (no) 2006-05-15
LT4927B (lt) 2002-07-25
DE60002117T2 (de) 2003-12-24
UA49974C2 (uk) 2002-10-15
TR200200148T2 (tr) 2002-06-21
EP1177166B1 (de) 2008-02-20
PL202956B1 (pl) 2009-08-31
BG104416A (en) 2001-03-30
TR200200147T2 (tr) 2002-06-21
ATE237579T1 (de) 2003-05-15
PT1052245E (pt) 2003-09-30
MXPA01011420A (es) 2002-06-04
EE04672B1 (de) 2006-08-15
CA2369393A1 (en) 2000-11-16
ATE252544T1 (de) 2003-11-15
PT1177167E (pt) 2004-03-31
NO20015352D0 (no) 2001-11-01
IL146420A0 (en) 2002-07-25
ATE386714T1 (de) 2008-03-15
LT2001109A (en) 2002-03-25
CN1353687A (zh) 2002-06-12
ES2302694T3 (es) 2008-08-01
EP1052245A2 (de) 2000-11-15
HU9901559D0 (en) 1999-07-28
CN1173928C (zh) 2004-11-03
CN1353686A (zh) 2002-06-12
CZ20001722A3 (cs) 2000-12-13
SK285635B6 (sk) 2007-05-03
BG104417A (en) 2001-03-30
NO20015336D0 (no) 2001-10-31
SI1177166T1 (sl) 2008-08-31
FR2793490B1 (fr) 2004-04-23
AU776696B2 (en) 2004-09-16
EP1052243A3 (de) 2001-02-28
AR023900A1 (es) 2002-09-04
EA200000411A3 (ru) 2001-02-26
EA002164B1 (ru) 2001-12-24
EP1177167A2 (de) 2002-02-06
KR20010112486A (ko) 2001-12-20
IL146420A (en) 2007-06-03
NO20015336L (no) 2002-01-08
CO5170480A1 (es) 2002-06-27
HRP20000291A2 (en) 2001-06-30
JP2002544184A (ja) 2002-12-24
EP1052243B1 (de) 2003-07-30
WO2000068183A2 (en) 2000-11-16
EP1052245B1 (de) 2003-04-16
ZA200108958B (en) 2002-10-30
HRP20000290A2 (en) 2005-02-28
MY122508A (en) 2006-04-29
BG64673B1 (bg) 2005-11-30
EE04638B1 (et) 2006-06-15
HK1031220A1 (en) 2001-06-08
KR20060010874A (ko) 2006-02-02
FR2793490A1 (fr) 2000-11-17
UA61122C2 (uk) 2003-11-17
EP1052245A3 (de) 2001-02-28
NZ515917A (en) 2004-02-27
TWI286541B (en) 2007-09-11
DE60038112T8 (de) 2009-05-28
DE60006097T2 (de) 2004-06-17
MY123523A (en) 2006-05-31
CA2373193A1 (en) 2000-11-16
DE60004126D1 (de) 2003-09-04
HUP9901559A2 (hu) 2002-01-28
CZ20014050A3 (cs) 2002-05-15
EA200000410A3 (ru) 2001-02-26
KR100685071B1 (ko) 2007-02-22
HRP20000291B1 (en) 2005-06-30
PT1177166E (pt) 2008-06-02
TW528742B (en) 2003-04-21
EE200100595A (et) 2003-02-17
JP4536265B2 (ja) 2010-09-01
SK285780B6 (sk) 2007-08-02
DE60002117D1 (de) 2003-05-22
DE60004126T2 (de) 2004-04-22
JP4031203B2 (ja) 2008-01-09
EA200000410A2 (ru) 2000-12-25
EP1177166A2 (de) 2002-02-06
NO20015352L (no) 2002-01-08
IL146421A0 (en) 2002-07-25
CZ291329B6 (cs) 2003-02-12
HRP20000290B1 (en) 2007-08-31
CA2369393C (en) 2010-07-06
AU777737B2 (en) 2004-10-28
KR100581489B1 (ko) 2006-05-22
SK6892000A3 (en) 2000-12-11
US6242386B1 (en) 2001-06-05
DK1177167T3 (da) 2004-03-01
DK1177166T3 (da) 2008-06-16
DK1052245T3 (da) 2003-08-11
CN1325465C (zh) 2007-07-11
EA200000411A2 (ru) 2000-12-25
IS2570B (is) 2010-01-15
LT2001108A (en) 2002-03-25
NO321487B1 (no) 2006-05-15
SI1052245T1 (en) 2003-10-31
SI1052243T1 (en) 2004-02-29
EE200100596A (et) 2003-02-17
IS6152A (is) 2001-11-09
IL146421A (en) 2008-11-26
US6624201B2 (en) 2003-09-23
BR0010412A (pt) 2002-02-13
FR2793489A1 (fr) 2000-11-17
IS6153A (is) 2001-11-09
AU4600300A (en) 2000-11-21
NZ515918A (en) 2004-02-27
AU4773100A (en) 2000-11-21
MXPA01011423A (es) 2002-06-04
ATE246170T1 (de) 2003-08-15
WO2000068183A3 (en) 2001-07-26
FR2793489B1 (fr) 2004-04-02
JP2002544185A (ja) 2002-12-24
ZA200108956B (en) 2003-02-17
ES2208328T3 (es) 2004-06-16
PL340107A1 (en) 2000-11-20

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