BG64673B1 - Метод за получаване на (1r,2s,4r)-(-)-2-[(2'-{n,n- диметиламино}- етокси)]-2-[фенил]-1,7,7-три-[метил]-бицикло[2.2.1] хептан и негови фармацевтично приемливи с киселина соли - Google Patents
Метод за получаване на (1r,2s,4r)-(-)-2-[(2'-{n,n- диметиламино}- етокси)]-2-[фенил]-1,7,7-три-[метил]-бицикло[2.2.1] хептан и негови фармацевтично приемливи с киселина соли Download PDFInfo
- Publication number
- BG64673B1 BG64673B1 BG104417A BG10441700A BG64673B1 BG 64673 B1 BG64673 B1 BG 64673B1 BG 104417 A BG104417 A BG 104417A BG 10441700 A BG10441700 A BG 10441700A BG 64673 B1 BG64673 B1 BG 64673B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- methyl
- bicyclo
- tri
- formula
- phenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 34
- 150000003839 salts Chemical class 0.000 title claims abstract description 27
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title claims abstract description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title claims abstract description 11
- 239000002253 acid Substances 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims abstract description 6
- 150000001875 compounds Chemical class 0.000 claims description 43
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 23
- 239000011541 reaction mixture Substances 0.000 claims description 22
- 238000006243 chemical reaction Methods 0.000 claims description 21
- 239000002904 solvent Substances 0.000 claims description 19
- 238000005804 alkylation reaction Methods 0.000 claims description 13
- -1 phenyl magnesium halide Chemical class 0.000 claims description 13
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 13
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 12
- 238000009835 boiling Methods 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 9
- 125000005843 halogen group Chemical group 0.000 claims description 7
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 6
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 claims description 5
- 150000001447 alkali salts Chemical class 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 150000002902 organometallic compounds Chemical class 0.000 claims description 4
- ANRQGKOBLBYXFM-UHFFFAOYSA-M phenylmagnesium bromide Chemical compound Br[Mg]C1=CC=CC=C1 ANRQGKOBLBYXFM-UHFFFAOYSA-M 0.000 claims description 4
- CETWDUZRCINIHU-UHFFFAOYSA-N 2-heptanol Chemical compound CCCCCC(C)O CETWDUZRCINIHU-UHFFFAOYSA-N 0.000 claims description 3
- KTAGTHGWHRJEGQ-UHFFFAOYSA-N 4,7,7-trimethyl-3-phenylbicyclo[2.2.1]heptane Chemical class CC1(C)C(C2)CCC1(C)C2C1=CC=CC=C1 KTAGTHGWHRJEGQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000007795 chemical reaction product Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000002955 isolation Methods 0.000 claims description 2
- PPOCFSJSVCAFQQ-UHFFFAOYSA-N 4,7,7-trimethylbicyclo[2.2.1]heptan-3-one Chemical compound C1CC2(C)C(=O)CC1C2(C)C.C1CC2(C)C(=O)CC1C2(C)C PPOCFSJSVCAFQQ-UHFFFAOYSA-N 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- IWCVDCOJSPWGRW-UHFFFAOYSA-M magnesium;benzene;chloride Chemical compound [Mg+2].[Cl-].C1=CC=[C-]C=C1 IWCVDCOJSPWGRW-UHFFFAOYSA-M 0.000 claims 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 36
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 32
- 229930007886 (R)-camphor Natural products 0.000 description 31
- 239000000047 product Substances 0.000 description 16
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 15
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 11
- 239000012535 impurity Substances 0.000 description 11
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 9
- 238000001953 recrystallisation Methods 0.000 description 9
- WQMAANNAZKNUDL-UHFFFAOYSA-N 2-dimethylaminoethyl chloride Chemical compound CN(C)CCCl WQMAANNAZKNUDL-UHFFFAOYSA-N 0.000 description 8
- 238000003747 Grignard reaction Methods 0.000 description 8
- 238000000746 purification Methods 0.000 description 8
- 238000010992 reflux Methods 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 230000029936 alkylation Effects 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 5
- 229910052783 alkali metal Inorganic materials 0.000 description 5
- 239000006227 byproduct Substances 0.000 description 5
- 239000001530 fumaric acid Substances 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- 229910000102 alkali metal hydride Inorganic materials 0.000 description 4
- 150000008046 alkali metal hydrides Chemical class 0.000 description 4
- QARVLSVVCXYDNA-UHFFFAOYSA-N bromobenzene Chemical compound BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 4
- DSSYKIVIOFKYAU-UHFFFAOYSA-N camphor Chemical compound C1CC2(C)C(=O)CC1C2(C)C DSSYKIVIOFKYAU-UHFFFAOYSA-N 0.000 description 4
- 239000012230 colorless oil Substances 0.000 description 4
- 238000005886 esterification reaction Methods 0.000 description 4
- 239000011975 tartaric acid Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 230000032050 esterification Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 159000000011 group IA salts Chemical class 0.000 description 3
- 229910000104 sodium hydride Inorganic materials 0.000 description 3
- 239000012312 sodium hydride Substances 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 235000002906 tartaric acid Nutrition 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 239000007818 Grignard reagent Substances 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000002168 alkylating agent Substances 0.000 description 2
- 229940100198 alkylating agent Drugs 0.000 description 2
- 239000000908 ammonium hydroxide Substances 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- CPWPJLJWUXOOAB-UHFFFAOYSA-N benzene;bromine Chemical compound [Br].C1=CC=CC=C1 CPWPJLJWUXOOAB-UHFFFAOYSA-N 0.000 description 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 2
- 229940116229 borneol Drugs 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 2
- 238000006266 etherification reaction Methods 0.000 description 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 150000004795 grignard reagents Chemical class 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 150000002736 metal compounds Chemical class 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 239000013557 residual solvent Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- GJOSGKNJWBGNSY-BMFZPTHFSA-N (1r,3s,4r)-4,7,7-trimethyl-3-phenylbicyclo[2.2.1]heptan-3-ol Chemical compound C1([C@]2(O)[C@]3(C)CC[C@@](C3(C)C)(C2)[H])=CC=CC=C1 GJOSGKNJWBGNSY-BMFZPTHFSA-N 0.000 description 1
- HFVMEOPYDLEHBR-UHFFFAOYSA-N (2-fluorophenyl)-phenylmethanol Chemical compound C=1C=CC=C(F)C=1C(O)C1=CC=CC=C1 HFVMEOPYDLEHBR-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- YJTKZCDBKVTVBY-UHFFFAOYSA-N 1,3-Diphenylbenzene Chemical group C1=CC=CC=C1C1=CC=CC(C=2C=CC=CC=2)=C1 YJTKZCDBKVTVBY-UHFFFAOYSA-N 0.000 description 1
- ACAKHSFNARGOES-UHFFFAOYSA-N 4,7,7-trimethylbicyclo[2.2.1]heptan-3-ol Chemical compound C1CC2(C)C(O)CC1C2(C)C.C1CC2(C)C(O)CC1C2(C)C ACAKHSFNARGOES-UHFFFAOYSA-N 0.000 description 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
- YIZWVEPEQPVVIS-WLHGVMLRSA-N C(\C=C\C(=O)O)(=O)O.C1(=CC=CC=C1)C1C2(CCC(C1)C2(C)C)C Chemical compound C(\C=C\C(=O)O)(=O)O.C1(=CC=CC=C1)C1C2(CCC(C1)C2(C)C)C YIZWVEPEQPVVIS-WLHGVMLRSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 150000008043 acidic salts Chemical class 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001339 alkali metal compounds Chemical class 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 230000002152 alkylating effect Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 230000000949 anxiolytic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004508 fractional distillation Methods 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 description 1
- 229910001623 magnesium bromide Inorganic materials 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- UMRZSTCPUPJPOJ-KNVOCYPGSA-N norbornane Chemical compound C1C[C@H]2CC[C@@H]1C2 UMRZSTCPUPJPOJ-KNVOCYPGSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- NHKJPPKXDNZFBJ-UHFFFAOYSA-N phenyllithium Chemical compound [Li]C1=CC=CC=C1 NHKJPPKXDNZFBJ-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 150000003388 sodium compounds Chemical class 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/12—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9901559A HU227114B1 (en) | 1999-05-11 | 1999-05-11 | (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG104417A BG104417A (en) | 2001-03-30 |
| BG64673B1 true BG64673B1 (bg) | 2005-11-30 |
Family
ID=89998272
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104417A BG64673B1 (bg) | 1999-05-11 | 2000-05-10 | Метод за получаване на (1r,2s,4r)-(-)-2-[(2'-{n,n- диметиламино}- етокси)]-2-[фенил]-1,7,7-три-[метил]-бицикло[2.2.1] хептан и негови фармацевтично приемливи с киселина соли |
| BG104416A BG64442B1 (en) | 1999-05-11 | 2000-05-10 | High purity (1r,2s,4r)-(-)-2-[(2'-[n,n-dimethylamino]-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane and its pharmaceutically acceptable salts, method for the preparation of these compounds and medicaments containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104416A BG64442B1 (en) | 1999-05-11 | 2000-05-10 | High purity (1r,2s,4r)-(-)-2-[(2'-[n,n-dimethylamino]-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]-bicyclo[2.2.1]heptane and its pharmaceutically acceptable salts, method for the preparation of these compounds and medicaments containing them |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US6335469B1 (de) |
| EP (4) | EP1052245B1 (de) |
| JP (2) | JP4536265B2 (de) |
| KR (3) | KR20060010874A (de) |
| CN (2) | CN1173928C (de) |
| AR (2) | AR023900A1 (de) |
| AT (4) | ATE252544T1 (de) |
| AU (2) | AU777737B2 (de) |
| BG (2) | BG64673B1 (de) |
| BR (2) | BR0010406A (de) |
| CA (2) | CA2373193A1 (de) |
| CO (1) | CO5170480A1 (de) |
| CZ (4) | CZ20014050A3 (de) |
| DE (4) | DE60038112T8 (de) |
| DK (4) | DK1177166T3 (de) |
| EA (2) | EA002164B1 (de) |
| EE (2) | EE04638B1 (de) |
| ES (4) | ES2302694T3 (de) |
| FR (2) | FR2793489B1 (de) |
| HK (2) | HK1031220A1 (de) |
| HR (2) | HRP20000291B1 (de) |
| HU (1) | HU227114B1 (de) |
| IL (4) | IL146421A0 (de) |
| IS (2) | IS6152A (de) |
| LT (2) | LT4927B (de) |
| MX (2) | MXPA01011420A (de) |
| MY (2) | MY123523A (de) |
| NO (2) | NO321486B1 (de) |
| NZ (2) | NZ515918A (de) |
| PL (2) | PL340107A1 (de) |
| PT (4) | PT1052243E (de) |
| SI (4) | SI1052245T1 (de) |
| SK (4) | SK6902000A3 (de) |
| TR (2) | TR200200148T2 (de) |
| TW (2) | TW528742B (de) |
| UA (2) | UA61122C2 (de) |
| WO (2) | WO2000068183A2 (de) |
| ZA (2) | ZA200108958B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227114B1 (en) * | 1999-05-11 | 2010-07-28 | Egis Gyogyszergyar Nyilvanosan | (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same |
| US6589996B2 (en) | 2000-03-17 | 2003-07-08 | Orion Corporation | Treatment of disorders relating to the serotonergic system |
| US20040082665A1 (en) * | 2001-01-22 | 2004-04-29 | Outi Maki-Ikola | Method for treating stress or tension |
| HUP0103017A3 (en) * | 2001-07-18 | 2004-05-28 | Egis Gyogyszergyar Nyilvanosan | Pharmaceutical composition for the treatment of diseases caused by impairment of cognitive functions and its use |
| GB0306604D0 (en) * | 2003-03-21 | 2003-04-30 | Curidium Ltd | Second medical use |
| HUP0301906A3 (en) * | 2003-06-23 | 2006-03-28 | Egis Gyogyszergyar Nyilvanosan | Use of bicyclo[2.2.1]heptane derivatives for producing of pharmaceutical compositions having neuroprotectiv activity |
| CA2559487A1 (en) * | 2004-03-12 | 2005-09-22 | Egis Gyogyszergyar Nyrt. | Combination of deramciclane and opoids as analgesics |
| JP4916680B2 (ja) * | 2005-06-30 | 2012-04-18 | 株式会社半導体エネルギー研究所 | 半導体装置の作製方法、剥離方法 |
| US20080258121A1 (en) * | 2007-04-23 | 2008-10-23 | Hasan Farooq | Fire Retardant Composition |
| WO2011061744A2 (en) | 2009-11-19 | 2011-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Novel arylated camphenes, processes for their preparation and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU179164B (en) * | 1979-12-14 | 1982-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing cycloalkyl-ethers of alkanolamines |
| HU212574B (en) * | 1990-09-21 | 1996-08-29 | Egyt Gyogyszervegyeszeti Gyar | Process for producing (1r,2s)-(-)-2-phenyl-(2'-dimethyl-amino-etoxy)-1,7,7-trimethyl-bicyclo[2.2.1.]heptane |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU214588B (hu) * | 1994-07-01 | 1998-04-28 | EGIS Gyógyszergyár Rt. | Eljárás bicikloheptán-származékot tartalmazó, CCK-rendszer gátló hatású gyógyászati készítmények előállítására |
| HU226061B1 (en) | 1996-10-17 | 2008-04-28 | Egis Gyogyszergyar Nyilvanosan | 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivative, pharmaceutical compositions containing the same and process for their preparation |
| HUP9900445A2 (hu) * | 1999-02-24 | 2001-06-28 | EGIS Gyógyszergyár Rt. | Eljárás (1R,2S,4R)-(-)-N,N-(dimetilamino-etoxi)-2-fenil-1,7,7-trimetil-biciklo[2.2.1]heptán előállítására és ennek köztiterméke |
| HU227114B1 (en) * | 1999-05-11 | 2010-07-28 | Egis Gyogyszergyar Nyilvanosan | (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same |
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1999
- 1999-05-11 HU HU9901559A patent/HU227114B1/hu not_active IP Right Cessation
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2000
- 2000-05-10 BR BR0010406-0A patent/BR0010406A/pt not_active Application Discontinuation
- 2000-05-10 HR HR20000291A patent/HRP20000291B1/xx not_active IP Right Cessation
- 2000-05-10 DK DK00927613T patent/DK1177166T3/da active
- 2000-05-10 SI SI200030124T patent/SI1052245T1/xx unknown
- 2000-05-10 SK SK690-2000A patent/SK6902000A3/sk unknown
- 2000-05-10 CA CA002373193A patent/CA2373193A1/en not_active Abandoned
- 2000-05-10 EP EP00110121A patent/EP1052245B1/de not_active Expired - Lifetime
- 2000-05-10 NZ NZ515918A patent/NZ515918A/xx not_active IP Right Cessation
- 2000-05-10 BG BG104417A patent/BG64673B1/bg unknown
- 2000-05-10 DK DK00929730T patent/DK1177167T3/da active
- 2000-05-10 UA UA2000052642A patent/UA61122C2/uk unknown
- 2000-05-10 JP JP2000617164A patent/JP4536265B2/ja not_active Expired - Fee Related
- 2000-05-10 PL PL00340107A patent/PL340107A1/xx not_active IP Right Cessation
- 2000-05-10 EA EA200000411A patent/EA002164B1/ru not_active IP Right Cessation
- 2000-05-10 HR HR20000290A patent/HRP20000290B1/xx not_active IP Right Cessation
- 2000-05-10 TW TW089108902A patent/TW528742B/zh not_active IP Right Cessation
- 2000-05-10 CN CNB008082391A patent/CN1173928C/zh not_active Expired - Fee Related
- 2000-05-10 EP EP00927613A patent/EP1177166B1/de not_active Expired - Lifetime
- 2000-05-10 EA EA200000410A patent/EA002163B1/ru not_active IP Right Cessation
- 2000-05-10 SI SI200030989T patent/SI1177166T1/sl unknown
- 2000-05-10 AR ARP000102239A patent/AR023900A1/es active IP Right Grant
- 2000-05-10 MY MYPI20002032A patent/MY123523A/en unknown
- 2000-05-10 PT PT00110122T patent/PT1052243E/pt unknown
- 2000-05-10 ES ES00927613T patent/ES2302694T3/es not_active Expired - Lifetime
- 2000-05-10 AT AT00929730T patent/ATE252544T1/de not_active IP Right Cessation
- 2000-05-10 SK SK1623-2001A patent/SK285635B6/sk not_active IP Right Cessation
- 2000-05-10 DE DE60038112T patent/DE60038112T8/de not_active Expired - Fee Related
- 2000-05-10 CO CO00033730A patent/CO5170480A1/es not_active Application Discontinuation
- 2000-05-10 IL IL14642100A patent/IL146421A0/xx active IP Right Grant
- 2000-05-10 BR BR0010412-4A patent/BR0010412A/pt not_active Application Discontinuation
- 2000-05-10 EE EEP200100595A patent/EE04638B1/xx not_active IP Right Cessation
- 2000-05-10 DE DE60006097T patent/DE60006097T2/de not_active Expired - Lifetime
- 2000-05-10 MX MXPA01011420A patent/MXPA01011420A/es active IP Right Grant
- 2000-05-10 DK DK00110121T patent/DK1052245T3/da active
- 2000-05-10 WO PCT/HU2000/000044 patent/WO2000068183A2/en not_active Application Discontinuation
- 2000-05-10 ES ES00929730T patent/ES2208328T3/es not_active Expired - Lifetime
- 2000-05-10 ES ES00110121T patent/ES2194643T3/es not_active Expired - Lifetime
- 2000-05-10 CZ CZ20014050A patent/CZ20014050A3/cs unknown
- 2000-05-10 EE EEP200100596A patent/EE200100596A/xx not_active IP Right Cessation
- 2000-05-10 AT AT00110122T patent/ATE246170T1/de not_active IP Right Cessation
- 2000-05-10 ES ES00110122T patent/ES2203373T3/es not_active Expired - Lifetime
- 2000-05-10 PL PL340108A patent/PL202956B1/pl not_active IP Right Cessation
- 2000-05-10 TR TR2002/00148T patent/TR200200148T2/xx unknown
- 2000-05-10 CZ CZ20001723A patent/CZ291329B6/cs not_active IP Right Cessation
- 2000-05-10 CA CA2369393A patent/CA2369393C/en not_active Expired - Fee Related
- 2000-05-10 MX MXPA01011423A patent/MXPA01011423A/es active IP Right Grant
- 2000-05-10 PT PT00929730T patent/PT1177167E/pt unknown
- 2000-05-10 PT PT00110121T patent/PT1052245E/pt unknown
- 2000-05-10 NZ NZ515917A patent/NZ515917A/xx unknown
- 2000-05-10 FR FR0005940A patent/FR2793489B1/fr not_active Expired - Fee Related
- 2000-05-10 WO PCT/HU2000/000043 patent/WO2000068181A2/en active IP Right Grant
- 2000-05-10 SK SK689-2000A patent/SK6892000A3/sk unknown
- 2000-05-10 US US09/569,046 patent/US6335469B1/en not_active Expired - Lifetime
- 2000-05-10 AT AT00927613T patent/ATE386714T1/de not_active IP Right Cessation
- 2000-05-10 US US09/569,050 patent/US6242386B1/en not_active Expired - Fee Related
- 2000-05-10 TR TR2002/00147T patent/TR200200147T2/xx unknown
- 2000-05-10 MY MYPI20002033A patent/MY122508A/en unknown
- 2000-05-10 KR KR1020067001294A patent/KR20060010874A/ko not_active Application Discontinuation
- 2000-05-10 AU AU47731/00A patent/AU777737B2/en not_active Ceased
- 2000-05-10 UA UA2000052641A patent/UA49974C2/uk unknown
- 2000-05-10 DE DE60004126T patent/DE60004126T2/de not_active Expired - Fee Related
- 2000-05-10 KR KR1020017014355A patent/KR100581489B1/ko not_active IP Right Cessation
- 2000-05-10 AR ARP000102244A patent/AR020860A1/es not_active Application Discontinuation
- 2000-05-10 EP EP00110122A patent/EP1052243B1/de not_active Expired - Lifetime
- 2000-05-10 KR KR1020017014354A patent/KR100685071B1/ko not_active IP Right Cessation
- 2000-05-10 CZ CZ20001722A patent/CZ290734B6/cs not_active IP Right Cessation
- 2000-05-10 CN CNB008083576A patent/CN1325465C/zh not_active Expired - Fee Related
- 2000-05-10 EP EP00929730A patent/EP1177167B1/de not_active Expired - Lifetime
- 2000-05-10 AU AU46003/00A patent/AU776696B2/en not_active Ceased
- 2000-05-10 JP JP2000617162A patent/JP4031203B2/ja not_active Expired - Fee Related
- 2000-05-10 TW TW089108901A patent/TWI286541B/zh not_active IP Right Cessation
- 2000-05-10 IL IL14642000A patent/IL146420A0/xx active IP Right Grant
- 2000-05-10 SI SI200030292T patent/SI1177167T1/xx unknown
- 2000-05-10 FR FR0005941A patent/FR2793490B1/fr not_active Expired - Fee Related
- 2000-05-10 DE DE60002117T patent/DE60002117T2/de not_active Expired - Lifetime
- 2000-05-10 AT AT00110121T patent/ATE237579T1/de not_active IP Right Cessation
- 2000-05-10 PT PT00927613T patent/PT1177166E/pt unknown
- 2000-05-10 SI SI200030219T patent/SI1052243T1/xx unknown
- 2000-05-10 SK SK1624-2001A patent/SK285780B6/sk not_active IP Right Cessation
- 2000-05-10 CZ CZ20014051A patent/CZ20014051A3/cs unknown
- 2000-05-10 BG BG104416A patent/BG64442B1/bg unknown
- 2000-05-10 DK DK00110122T patent/DK1052243T3/da active
- 2000-12-14 HK HK00108103A patent/HK1031220A1/xx not_active IP Right Cessation
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2001
- 2001-01-27 HK HK01100582A patent/HK1031372A1/xx not_active IP Right Cessation
- 2001-10-30 ZA ZA200108958A patent/ZA200108958B/en unknown
- 2001-10-30 ZA ZA200108956A patent/ZA200108956B/en unknown
- 2001-10-30 US US09/984,542 patent/US6624201B2/en not_active Expired - Lifetime
- 2001-10-31 NO NO20015336A patent/NO321486B1/no not_active IP Right Cessation
- 2001-11-01 NO NO20015352A patent/NO321487B1/no unknown
- 2001-11-08 LT LT2001109A patent/LT4927B/lt not_active IP Right Cessation
- 2001-11-08 LT LT2001108A patent/LT4928B/lt not_active IP Right Cessation
- 2001-11-09 IS IS6152A patent/IS6152A/is unknown
- 2001-11-09 IS IS6153A patent/IS2570B/is unknown
- 2001-11-11 IL IL146421A patent/IL146421A/en not_active IP Right Cessation
- 2001-11-11 IL IL146420A patent/IL146420A/en not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU179164B (en) * | 1979-12-14 | 1982-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing cycloalkyl-ethers of alkanolamines |
| HU212574B (en) * | 1990-09-21 | 1996-08-29 | Egyt Gyogyszervegyeszeti Gyar | Process for producing (1r,2s)-(-)-2-phenyl-(2'-dimethyl-amino-etoxy)-1,7,7-trimethyl-bicyclo[2.2.1.]heptane |
Also Published As
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