ATE246170T1 - Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- ((2'-(n,n-dimethylamino)-ethoxy))-2-(phenyl)-1, , 7-tri-(methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze - Google Patents

Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- ((2'-(n,n-dimethylamino)-ethoxy))-2-(phenyl)-1, , 7-tri-(methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze

Info

Publication number
ATE246170T1
ATE246170T1 AT00110122T AT00110122T ATE246170T1 AT E246170 T1 ATE246170 T1 AT E246170T1 AT 00110122 T AT00110122 T AT 00110122T AT 00110122 T AT00110122 T AT 00110122T AT E246170 T1 ATE246170 T1 AT E246170T1
Authority
AT
Austria
Prior art keywords
bicyclo
heptane
dimethylamino
ethoxy
tri
Prior art date
Application number
AT00110122T
Other languages
English (en)
Inventor
Gyula Lukacs
Gyula Simig
Tibor Mezei
Zoltan Budai
Marta Porcs-Makkay
Gyorgy Krasznai
Kalman Nagy
Gyorgyi Donath Vereczkey
Tibor Szabo
Norbert Nemeth
Janos Szulagyi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of ATE246170T1 publication Critical patent/ATE246170T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/12—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00110122T 1999-05-11 2000-05-10 Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- ((2'-(n,n-dimethylamino)-ethoxy))-2-(phenyl)-1, , 7-tri-(methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze ATE246170T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9901559A HU227114B1 (en) 1999-05-11 1999-05-11 (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same

Publications (1)

Publication Number Publication Date
ATE246170T1 true ATE246170T1 (de) 2003-08-15

Family

ID=89998272

Family Applications (4)

Application Number Title Priority Date Filing Date
AT00927613T ATE386714T1 (de) 1999-05-11 2000-05-10 Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- (2'-(n,n-dimethylamino)-ethoxy) -2- phenyl -1,7, 7-tri- methyl -bicyclo[2.2.1 heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze
AT00929730T ATE252544T1 (de) 1999-05-11 2000-05-10 Hochreine (1r, 2s, 4r)-(-)-2-((2'-(n,n- dimethylamino)-ethoxy))-2-(phenyl)-1,7,7-tri- (methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze, verfahren zu ihrer herstellung sowie sie enthaltendes medikament.
AT00110121T ATE237579T1 (de) 1999-05-11 2000-05-10 Hochreine (1r, 2s, 4r)-(-)-2-((2'-(n,n- dimethylamino)-ethoxy))-2-(phenyl)-1,7,7-tri- (methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze, verfahren zu ihrer herstellung sowie sie enthaltendes medikament.
AT00110122T ATE246170T1 (de) 1999-05-11 2000-05-10 Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- ((2'-(n,n-dimethylamino)-ethoxy))-2-(phenyl)-1, , 7-tri-(methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze

Family Applications Before (3)

Application Number Title Priority Date Filing Date
AT00927613T ATE386714T1 (de) 1999-05-11 2000-05-10 Verfahren zur herstellung von (1r, 2s, 4r)-(-)-2- (2'-(n,n-dimethylamino)-ethoxy) -2- phenyl -1,7, 7-tri- methyl -bicyclo[2.2.1 heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze
AT00929730T ATE252544T1 (de) 1999-05-11 2000-05-10 Hochreine (1r, 2s, 4r)-(-)-2-((2'-(n,n- dimethylamino)-ethoxy))-2-(phenyl)-1,7,7-tri- (methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze, verfahren zu ihrer herstellung sowie sie enthaltendes medikament.
AT00110121T ATE237579T1 (de) 1999-05-11 2000-05-10 Hochreine (1r, 2s, 4r)-(-)-2-((2'-(n,n- dimethylamino)-ethoxy))-2-(phenyl)-1,7,7-tri- (methyl)-bicyclo(2.2.1)heptan und ihre pharmazeutisch akzeptierbaren säure-additions- salze, verfahren zu ihrer herstellung sowie sie enthaltendes medikament.

Country Status (37)

Country Link
US (3) US6242386B1 (de)
EP (4) EP1177166B1 (de)
JP (2) JP4536265B2 (de)
KR (3) KR20060010874A (de)
CN (2) CN1325465C (de)
AR (2) AR020860A1 (de)
AT (4) ATE386714T1 (de)
AU (2) AU777737B2 (de)
BG (2) BG64673B1 (de)
BR (2) BR0010406A (de)
CA (2) CA2369393C (de)
CO (1) CO5170480A1 (de)
CZ (4) CZ291329B6 (de)
DE (4) DE60006097T2 (de)
DK (4) DK1052245T3 (de)
EA (2) EA002164B1 (de)
EE (2) EE04638B1 (de)
ES (4) ES2203373T3 (de)
FR (2) FR2793489B1 (de)
HR (2) HRP20000291B1 (de)
HU (1) HU227114B1 (de)
IL (4) IL146421A0 (de)
IS (2) IS6152A (de)
LT (2) LT4927B (de)
MX (2) MXPA01011423A (de)
MY (2) MY122508A (de)
NO (2) NO321486B1 (de)
NZ (2) NZ515917A (de)
PL (2) PL202956B1 (de)
PT (4) PT1177167E (de)
SI (4) SI1177167T1 (de)
SK (4) SK285780B6 (de)
TR (2) TR200200148T2 (de)
TW (2) TW528742B (de)
UA (2) UA61122C2 (de)
WO (2) WO2000068181A2 (de)
ZA (2) ZA200108958B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227114B1 (en) * 1999-05-11 2010-07-28 Egis Gyogyszergyar Nyilvanosan (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same
US6589996B2 (en) 2000-03-17 2003-07-08 Orion Corporation Treatment of disorders relating to the serotonergic system
US20040082665A1 (en) * 2001-01-22 2004-04-29 Outi Maki-Ikola Method for treating stress or tension
HUP0103017A3 (en) * 2001-07-18 2004-05-28 Egis Gyogyszergyar Nyilvanosan Pharmaceutical composition for the treatment of diseases caused by impairment of cognitive functions and its use
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
HUP0301906A3 (en) * 2003-06-23 2006-03-28 Egis Gyogyszergyar Nyilvanosan Use of bicyclo[2.2.1]heptane derivatives for producing of pharmaceutical compositions having neuroprotectiv activity
SK50812006A3 (sk) * 2004-03-12 2007-03-01 Egis Gy�gyszergy�r Nyrt. Kombinácia deramciklanu a opioidov ako analgetík
JP4916680B2 (ja) * 2005-06-30 2012-04-18 株式会社半導体エネルギー研究所 半導体装置の作製方法、剥離方法
US20080258121A1 (en) * 2007-04-23 2008-10-23 Hasan Farooq Fire Retardant Composition
BR112012010518A2 (pt) 2009-11-19 2016-03-15 Yissum Res Dev Co composto, composição farmacêutica, uso de composto, métodos para estimular um receptor de cb, para tratar uma doença, um distúrbio ou uma condição, para diminuir dano secundário, para a formação de c-amp, processo para a preparação de um composto, e, método para estímulo do crescimento ósseo, massa óssea, reparo ósseo ou prevenção da perda óssea.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179164B (en) * 1979-12-14 1982-08-28 Egyt Gyogyszervegyeszeti Gyar Process for producing cycloalkyl-ethers of alkanolamines
HU212574B (en) * 1990-09-21 1996-08-29 Egyt Gyogyszervegyeszeti Gyar Process for producing (1r,2s)-(-)-2-phenyl-(2'-dimethyl-amino-etoxy)-1,7,7-trimethyl-bicyclo[2.2.1.]heptane
HU214588B (hu) * 1994-07-01 1998-04-28 EGIS Gyógyszergyár Rt. Eljárás bicikloheptán-származékot tartalmazó, CCK-rendszer gátló hatású gyógyászati készítmények előállítására
HU226061B1 (en) 1996-10-17 2008-04-28 Egis Gyogyszergyar Nyilvanosan 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivative, pharmaceutical compositions containing the same and process for their preparation
HUP9900445A2 (hu) 1999-02-24 2001-06-28 EGIS Gyógyszergyár Rt. Eljárás (1R,2S,4R)-(-)-N,N-(dimetilamino-etoxi)-2-fenil-1,7,7-trimetil-biciklo[2.2.1]heptán előállítására és ennek köztiterméke
HU227114B1 (en) * 1999-05-11 2010-07-28 Egis Gyogyszergyar Nyilvanosan (1r, 2s, 4r)-(-)-2-[n,n-(dimethylamino-ethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane of high purity and pharmaceutically acceptable acid addition salts thereof, process for preparation of them and medicaments containing the same

Also Published As

Publication number Publication date
CA2369393C (en) 2010-07-06
IS6153A (is) 2001-11-09
NO20015336L (no) 2002-01-08
EE200100596A (et) 2003-02-17
EP1052245A2 (de) 2000-11-15
US6242386B1 (en) 2001-06-05
BG104416A (en) 2001-03-30
EP1052243A2 (de) 2000-11-15
US20020040164A1 (en) 2002-04-04
DE60038112T2 (de) 2009-02-12
MXPA01011420A (es) 2002-06-04
DE60002117T2 (de) 2003-12-24
WO2000068183A2 (en) 2000-11-16
HK1031220A1 (en) 2001-06-08
EP1052245B1 (de) 2003-04-16
AR023900A1 (es) 2002-09-04
ATE386714T1 (de) 2008-03-15
US6624201B2 (en) 2003-09-23
FR2793490B1 (fr) 2004-04-23
IS6152A (is) 2001-11-09
DE60002117D1 (de) 2003-05-22
CN1325465C (zh) 2007-07-11
EA200000411A2 (ru) 2000-12-25
CN1353686A (zh) 2002-06-12
DE60006097T2 (de) 2004-06-17
EP1177167A2 (de) 2002-02-06
NO321487B1 (no) 2006-05-15
ES2302694T3 (es) 2008-08-01
TW528742B (en) 2003-04-21
JP4031203B2 (ja) 2008-01-09
LT4927B (lt) 2002-07-25
HRP20000291B1 (en) 2005-06-30
IL146420A0 (en) 2002-07-25
MY123523A (en) 2006-05-31
AU776696B2 (en) 2004-09-16
NZ515918A (en) 2004-02-27
WO2000068181A3 (en) 2001-06-28
FR2793489B1 (fr) 2004-04-02
BG104417A (en) 2001-03-30
HRP20000291A2 (en) 2001-06-30
ZA200108956B (en) 2003-02-17
US6335469B1 (en) 2002-01-01
UA61122C2 (uk) 2003-11-17
WO2000068181A2 (en) 2000-11-16
EA002164B1 (ru) 2001-12-24
EA002163B1 (ru) 2001-12-24
TR200200147T2 (tr) 2002-06-21
SK285780B6 (sk) 2007-08-02
EP1177166B1 (de) 2008-02-20
NZ515917A (en) 2004-02-27
EE04638B1 (et) 2006-06-15
LT2001109A (en) 2002-03-25
DE60006097D1 (de) 2003-11-27
DK1177166T3 (da) 2008-06-16
PT1177167E (pt) 2004-03-31
AU4773100A (en) 2000-11-21
JP2002544184A (ja) 2002-12-24
CA2373193A1 (en) 2000-11-16
EA200000410A2 (ru) 2000-12-25
BG64442B1 (en) 2005-02-28
CN1173928C (zh) 2004-11-03
WO2000068183A3 (en) 2001-07-26
ATE237579T1 (de) 2003-05-15
JP2002544185A (ja) 2002-12-24
SK285635B6 (sk) 2007-05-03
UA49974C2 (uk) 2002-10-15
ES2194643T3 (es) 2003-12-01
CZ20014050A3 (cs) 2002-05-15
TR200200148T2 (tr) 2002-06-21
ATE252544T1 (de) 2003-11-15
HK1031372A1 (en) 2001-06-15
JP4536265B2 (ja) 2010-09-01
AR020860A1 (es) 2002-05-29
SI1052245T1 (en) 2003-10-31
DK1177167T3 (da) 2004-03-01
HRP20000290A2 (en) 2005-02-28
CO5170480A1 (es) 2002-06-27
PL202956B1 (pl) 2009-08-31
DE60004126T2 (de) 2004-04-22
FR2793490A1 (fr) 2000-11-17
HU227114B1 (en) 2010-07-28
CZ291329B6 (cs) 2003-02-12
IL146420A (en) 2007-06-03
DK1052243T3 (da) 2003-11-24
EE04672B1 (de) 2006-08-15
IS2570B (is) 2010-01-15
EP1052245A3 (de) 2001-02-28
PT1052243E (pt) 2003-12-31
KR20020010914A (ko) 2002-02-06
PL340108A1 (en) 2000-11-20
TWI286541B (en) 2007-09-11
SI1052243T1 (en) 2004-02-29
LT2001108A (en) 2002-03-25
DK1052245T3 (da) 2003-08-11
DE60038112D1 (de) 2008-04-03
HRP20000290B1 (en) 2007-08-31
PT1177166E (pt) 2008-06-02
EP1177167B1 (de) 2003-10-22
MY122508A (en) 2006-04-29
SK16232001A3 (sk) 2002-04-04
CA2369393A1 (en) 2000-11-16
FR2793489A1 (fr) 2000-11-17
IL146421A0 (en) 2002-07-25
HU9901559D0 (en) 1999-07-28
DE60004126D1 (de) 2003-09-04
LT4928B (lt) 2002-07-25
DE60038112T8 (de) 2009-05-28
MXPA01011423A (es) 2002-06-04
HUP9901559A2 (hu) 2002-01-28
EA200000410A3 (ru) 2001-02-26
BR0010406A (pt) 2002-02-13
NO20015352D0 (no) 2001-11-01
IL146421A (en) 2008-11-26
CN1353687A (zh) 2002-06-12
BR0010412A (pt) 2002-02-13
KR20060010874A (ko) 2006-02-02
PT1052245E (pt) 2003-09-30
EP1052243A3 (de) 2001-02-28
EE200100595A (et) 2003-02-17
AU4600300A (en) 2000-11-21
EP1052243B1 (de) 2003-07-30
ES2208328T3 (es) 2004-06-16
NO20015336D0 (no) 2001-10-31
KR20010112486A (ko) 2001-12-20
PL340107A1 (en) 2000-11-20
NO20015352L (no) 2002-01-08
SK16242001A3 (sk) 2002-04-04
CZ20014051A3 (cs) 2002-05-15
SI1177166T1 (sl) 2008-08-31
CZ290734B6 (cs) 2002-10-16
EP1177166A2 (de) 2002-02-06
BG64673B1 (bg) 2005-11-30
ZA200108958B (en) 2002-10-30
CZ20001723A3 (cs) 2000-12-13
AU777737B2 (en) 2004-10-28
CZ20001722A3 (cs) 2000-12-13
NO321486B1 (no) 2006-05-15
KR100581489B1 (ko) 2006-05-22
SK6892000A3 (en) 2000-12-11
SI1177167T1 (en) 2004-04-30
EA200000411A3 (ru) 2001-02-26
ES2203373T3 (es) 2004-04-16
SK6902000A3 (en) 2000-12-11
KR100685071B1 (ko) 2007-02-22

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