ZA200503834B - 2'-branched nucleosides and Flaviviridae mutation - Google Patents

2'-branched nucleosides and Flaviviridae mutation

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Publication number
ZA200503834B
ZA200503834B ZA200503834A ZA200503834A ZA200503834B ZA 200503834 B ZA200503834 B ZA 200503834B ZA 200503834 A ZA200503834 A ZA 200503834A ZA 200503834 A ZA200503834 A ZA 200503834A ZA 200503834 B ZA200503834 B ZA 200503834B
Authority
ZA
South Africa
Prior art keywords
branched nucleosides
flaviviridae
mutation
flaviviridae mutation
nucleosides
Prior art date
Application number
ZA200503834A
Other languages
English (en)
Inventor
Sammadossi Jean-Pierre
Standring David
Qu Lin
La Colla Paolo
Bichko Vadim
Original Assignee
Idenix Ltd
Univ Cagliari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32326395&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200503834(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Idenix Ltd, Univ Cagliari filed Critical Idenix Ltd
Publication of ZA200503834B publication Critical patent/ZA200503834B/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/21—Interferons [IFN]
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    • A61K38/21—Interferons [IFN]
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G01N2333/183—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
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ZA200503834A 2002-11-15 2005-05-12 2'-branched nucleosides and Flaviviridae mutation ZA200503834B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42667502P 2002-11-15 2002-11-15

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ZA200503834B true ZA200503834B (en) 2009-05-27

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Country Link
US (4) US7824851B2 (fr)
EP (1) EP1576138B1 (fr)
JP (4) JP2006519753A (fr)
KR (1) KR20050088079A (fr)
CN (1) CN1849142A (fr)
AU (1) AU2003298658A1 (fr)
BR (1) BR0316363A (fr)
CA (1) CA2506129C (fr)
CY (1) CY1118931T1 (fr)
DK (1) DK1576138T3 (fr)
ES (1) ES2624353T3 (fr)
HU (1) HUE033832T2 (fr)
LT (1) LT1576138T (fr)
MX (1) MXPA05005192A (fr)
NO (1) NO20052920L (fr)
PL (1) PL377342A1 (fr)
PT (1) PT1576138T (fr)
RU (1) RU2005118421A (fr)
SI (1) SI1576138T1 (fr)
WO (1) WO2004046331A2 (fr)
ZA (1) ZA200503834B (fr)

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JP5230052B2 (ja) * 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
AU2003209045B2 (en) 2002-02-13 2006-12-14 Isis Pharmaceuticals, Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
WO2004002422A2 (fr) * 2002-06-28 2004-01-08 Idenix (Cayman) Limited Ester 3'-l-valine de ?-d-2'-c-methyl-ribofuranosyl cytidine pour le traitement d'infections par des flaviviridae
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7323449B2 (en) 2002-07-24 2008-01-29 Merck & Co., Inc. Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
CA2506129C (fr) * 2002-11-15 2015-02-17 Idenix (Cayman) Limited Nucleoside a ramification en 2' et mutation de flaviviridae
AU2003300901A1 (en) * 2002-12-12 2004-06-30 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
NZ540913A (en) * 2002-12-23 2008-02-29 Idenix Cayman Ltd Process for the production of 3'-nucleoside prodrugs
WO2005003147A2 (fr) 2003-05-30 2005-01-13 Pharmasset, Inc. Analogues de nucleosides fluores modifies
WO2005009418A2 (fr) 2003-07-25 2005-02-03 Idenix (Cayman) Limited Analogues des nucleosides puriques pour traiter flaviviridae et notamment l'hepatite c
US20050182252A1 (en) 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
AU2005254057B2 (en) 2004-06-15 2011-02-17 Isis Pharmaceuticals, Inc. C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
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PT1576138T (pt) 2017-05-03
WO2004046331A3 (fr) 2006-03-02
US20110129813A1 (en) 2011-06-02
JP2014166183A (ja) 2014-09-11
JP2016136946A (ja) 2016-08-04
NO20052920D0 (no) 2005-06-15
MXPA05005192A (es) 2005-09-08
WO2004046331A2 (fr) 2004-06-03
US10525072B2 (en) 2020-01-07
PL377342A1 (pl) 2006-01-23
US8674085B2 (en) 2014-03-18
JP2011024578A (ja) 2011-02-10
BR0316363A (pt) 2005-10-04
DK1576138T3 (en) 2017-05-01
EP1576138A2 (fr) 2005-09-21
CA2506129C (fr) 2015-02-17
LT1576138T (lt) 2017-06-26
ES2624353T3 (es) 2017-07-13
EP1576138A4 (fr) 2008-09-03
CA2506129A1 (fr) 2004-06-03
CY1118931T1 (el) 2018-01-10
US20140286900A1 (en) 2014-09-25
US7824851B2 (en) 2010-11-02
JP6063073B2 (ja) 2017-01-18
NO20052920L (no) 2005-08-15
JP5936176B2 (ja) 2016-06-15
HUE033832T2 (en) 2018-01-29
EP1576138B1 (fr) 2017-02-01
SI1576138T1 (sl) 2017-07-31
US20050031588A1 (en) 2005-02-10
JP6104845B2 (ja) 2017-03-29
US20160166597A1 (en) 2016-06-16
CN1849142A (zh) 2006-10-18
AU2003298658A1 (en) 2004-06-15
JP2006519753A (ja) 2006-08-31
RU2005118421A (ru) 2006-01-20

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