YU47212B - Postupak za dobijanje imidazopiridazinskih derivata - Google Patents

Postupak za dobijanje imidazopiridazinskih derivata

Info

Publication number
YU47212B
YU47212B YU202889A YU202889A YU47212B YU 47212 B YU47212 B YU 47212B YU 202889 A YU202889 A YU 202889A YU 202889 A YU202889 A YU 202889A YU 47212 B YU47212 B YU 47212B
Authority
YU
Yugoslavia
Prior art keywords
group
optionally substituted
compound
alkyl
optionally
Prior art date
Application number
YU202889A
Other languages
English (en)
Other versions
YU202889A (en
Inventor
S.T. Hodgson
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of YU202889A publication Critical patent/YU202889A/xx
Publication of YU47212B publication Critical patent/YU47212B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE IMIDAZOPIRIDAZINSKIH DERIVATA, opste formule (I) u kojoj R1 predstavlja opciono supstituisanu karbociklicnu aril grupu koja ima 6 ili 10 clanova u prstenu i koja sadrzi najmanje jedan aromaticni prsten, opciono supstituisanu heterociklicnu aril grupu koja ima 5 do 10 clanova u prstenu, ili opciono supstituicanu C1-10 alkil, C2-10 alkenil, C3-10 cikloalkil ili C3-10 cikloalkenil grupu; R2 predstavlja opciono supstituisanu C1-10 alkil, C2-10 alkenil, C2-10 alkinil, C3-10 cikloalkil, C3-10 cikloalkenil, opciono supstituisanu karbociklicnu aril grupu koja ima 6 do 10 clanova u prstenu i sadrzi najmanje jedan aromatican prsten, opciono supstituisanu heterocik-licnu grupu koja ima 5 do 10 clanova u prstenu ili opciono supstituisanu aril (C1-14) alkil grupu gde je aril deo karbociklicna ili heterociklicna aril grupa kao sto je ovde ranije definisano; R3 predstavlja vodonikov atom ili C1-4 alkil grupu; X predstavlja atom kiseonika ili sumpora, grupu -CH2 - ili grupu NR4 gde R4 predstavlja vodonikov atom ili C1-4 alkil grupu; i Y predstavlja grupu -CH2 ili -CH2CH2 ili X-Y predstavlja grupu -CH=CH-i njihovih farmaceutski prihvatljivih soli, naznacen time, sto obuhvata: reakciju pozeljno grejanjem jedinjenja opste formule (VI) do temperature u opsegu od oko 80°C do oko 150°C, opciono u prisustvu inertnih organskih rastvaraca kao sto su ugljovodonici benzol i toluolsa odgovarajucim alkoholom R2OH pri cemu R1, R2, X i Y imaju gore data znacenja, posle cega se, ukoliko se zeli i/ili ako je potrebno, dobivena jedinjenja formule (I) mogu prevesti u druga jedinjenja formule (I) pomocu: - odvajanja grupe -CO2R2 pod kiselim uslovima, opciono u prisustvu rastvaraca, i onda reakcijom sa reagensom za uvodjenje razlicite -CO2R2 grupe; - zamene esterifikujuce grupe R2 u jedinjenju formule (I) tretiranjem pomenutog jedinjenja sa odgovarajucim alkolohom u prisustvu baze na temperature u intervalu 50 do 180°C; ili - alkilovanja jedinjenja u kojem je R3 vodonik tako da se obezbedi jedinjenje u kojem je R3 alkil grupa; i/ili vrsi se obrazovanje soli. Prijava sadrzi jos 6 zavisnih zahteva.
YU202889A 1987-08-15 1989-10-18 Postupak za dobijanje imidazopiridazinskih derivata YU47212B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878719368A GB8719368D0 (en) 1987-08-15 1987-08-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
YU202889A YU202889A (en) 1990-04-30
YU47212B true YU47212B (sh) 1995-01-31

Family

ID=10622364

Family Applications (3)

Application Number Title Priority Date Filing Date
YU156988A YU47200B (sh) 1987-08-15 1988-08-12 Postupak za dobijanje imidazopiridazinskih derivata
YU202889A YU47212B (sh) 1987-08-15 1989-10-18 Postupak za dobijanje imidazopiridazinskih derivata
YU202789A YU47130B (sh) 1987-08-15 1989-10-18 Postupak za dobijanje imidazopiridazinskih derivata

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU156988A YU47200B (sh) 1987-08-15 1988-08-12 Postupak za dobijanje imidazopiridazinskih derivata

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU202789A YU47130B (sh) 1987-08-15 1989-10-18 Postupak za dobijanje imidazopiridazinskih derivata

Country Status (28)

Country Link
US (5) US5091531A (sh)
EP (1) EP0305093B1 (sh)
JP (1) JPS6468375A (sh)
KR (1) KR890003764A (sh)
CN (2) CN1031532A (sh)
AP (1) AP89A (sh)
AT (1) ATE103919T1 (sh)
AU (1) AU613392B2 (sh)
CA (1) CA1336432C (sh)
DD (1) DD289529A5 (sh)
DE (1) DE3888897T2 (sh)
DK (1) DK168954B1 (sh)
ES (1) ES2063039T3 (sh)
FI (1) FI89600C (sh)
GB (1) GB8719368D0 (sh)
HU (1) HU204052B (sh)
IL (1) IL87435A (sh)
MC (1) MC1969A1 (sh)
MX (1) MX12655A (sh)
MY (1) MY103602A (sh)
NO (1) NO168305C (sh)
NZ (1) NZ225808A (sh)
PH (1) PH25741A (sh)
PL (3) PL159008B1 (sh)
PT (1) PT88260B (sh)
RU (3) RU1769759C (sh)
YU (3) YU47200B (sh)
ZA (1) ZA885996B (sh)

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GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
PH27291A (en) * 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use
EP0440119A1 (en) * 1990-01-31 1991-08-07 Takeda Chemical Industries, Ltd. Imidazopyridazine compounds, their production and use
EP0444549B1 (en) * 1990-03-01 1995-01-25 Takeda Chemical Industries, Ltd. Imidazopyridazines their production and use
ATE256128T1 (de) * 1998-10-21 2003-12-15 Takeda Chemical Industries Ltd Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung
CN1592624A (zh) * 2000-06-30 2005-03-09 惠氏公司 被取代的三唑并嘧啶类化合物作为抗癌药
JP3767352B2 (ja) 2000-09-18 2006-04-19 トヨタ自動車株式会社 内燃機関の制御装置
WO2002083675A2 (en) * 2001-04-10 2002-10-24 Merck Sharp & Dohme Limited Inhibitors of akt activity
AR062207A1 (es) * 2006-08-04 2008-10-22 Takeda Pharmaceutical Derivados de imidazopiridazina inhibidores de quinasas utiles para prevenir y/o tratar el cancer.
WO2008058126A2 (en) * 2006-11-06 2008-05-15 Supergen, Inc. Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
US8431608B2 (en) 2007-08-17 2013-04-30 Icagen Inc. Heterocycles as potassium channel modulators
US8058274B2 (en) * 2007-08-17 2011-11-15 Icagen, Inc. Heterocycles as potassium channel modulators
JP5576802B2 (ja) * 2008-02-28 2014-08-20 ノバルティス アーゲー Ｃ−Ｍｅｔチロシンキナーゼ介在疾患の治療用のイミダゾ［１，２−ｂ］ピリダジン誘導体
EP2277881A4 (en) * 2008-04-18 2011-09-07 Shionogi & Co HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K
UY32049A (es) * 2008-08-14 2010-03-26 Takeda Pharmaceutical Inhibidores de cmet
TW201437211A (zh) * 2013-03-01 2014-10-01 Bayer Pharma AG 經取代咪唑并嗒□

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US3809691A (en) * 1967-10-23 1974-05-07 Eastman Kodak Co Novel cyanine dyes with fused imidazolo nuclei
US3615639A (en) * 1967-10-23 1971-10-26 Eastman Kodak Co Direct positive silver halide emulsions containing dyes as electron acceptors and spectral sensitizers
DE2043811A1 (en) * 1970-09-03 1972-03-09 E.I. du Pont de Nemours and Co., Wilmington, Del. (V.StA.) Fungicidal and acaricidal alkyl 2-benzimi- - dazole carbomate derivs
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DE3446812A1 (de) * 1984-12-21 1986-06-26 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3446778A1 (de) * 1984-12-21 1986-07-03 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3527036A1 (de) * 1985-07-27 1987-02-05 Merck Patent Gmbh 6-arylalkenylpyridazinone
DE3542661A1 (de) * 1985-12-03 1987-06-04 Bayer Ag Imidazopyridazinalkensaeureamide, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
WO1989001478A1 (en) * 1987-08-07 1989-02-23 The Australian National University ARYLOXY- AND ARALKYLTHIO-IMIDAZO[1,2-b]PYRIDAZINES
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
EP0305093A1 (en) 1989-03-01
YU47130B (sh) 1994-12-28
RU1769759C (ru) 1992-10-15
NZ225808A (en) 1991-07-26
PT88260B (pt) 1995-03-01
AP89A (en) 1990-06-14
MX12655A (es) 1993-10-01
US5380759A (en) 1995-01-10
PT88260A (pt) 1989-09-14
DK168954B1 (da) 1994-07-18
US5538970A (en) 1996-07-23
NO883613L (no) 1989-02-16
KR890003764A (ko) 1989-04-17
PH25741A (en) 1991-10-18
AU613392B2 (en) 1991-08-01
JPS6468375A (en) 1989-03-14
US5091531A (en) 1992-02-25
FI883758A (fi) 1989-02-16
CA1336432C (en) 1995-07-25
DD289529A5 (de) 1991-05-02
YU47200B (sh) 1995-01-31
YU156988A (en) 1990-04-30
NO883613D0 (no) 1988-08-12
RU1836372C (ru) 1993-08-23
US5371219A (en) 1994-12-06
FI89600C (fi) 1993-10-25
HU204052B (en) 1991-11-28
AU2097988A (en) 1989-02-16
YU202789A (en) 1990-04-30
DK451588A (da) 1989-02-16
YU202889A (en) 1990-04-30
GB8719368D0 (en) 1987-09-23
IL87435A0 (en) 1989-01-31
FI883758A0 (fi) 1988-08-12
ATE103919T1 (de) 1994-04-15
EP0305093B1 (en) 1994-04-06
DE3888897D1 (de) 1994-05-11
PL160045B1 (en) 1993-02-26
DK451588D0 (da) 1988-08-12
HUT50473A (en) 1990-02-28
NO168305C (no) 1992-02-05
NO168305B (no) 1991-10-28
DE3888897T2 (de) 1994-10-20
PL160044B1 (pl) 1993-02-26
FI89600B (fi) 1993-07-15
IL87435A (en) 1993-01-31
ES2063039T3 (es) 1995-01-01
RU2017741C1 (ru) 1994-08-15
MC1969A1 (fr) 1989-09-29
US5447956A (en) 1995-09-05
ZA885996B (en) 1990-04-25
PL159008B1 (pl) 1992-11-30
AP8800098A0 (en) 1988-08-01
CN1031532A (zh) 1989-03-08
MY103602A (en) 1993-08-28
CN1085901A (zh) 1994-04-27
PL274216A1 (en) 1989-05-02

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