KR900009658A - 아실화 방법 - Google Patents

아실화 방법 Download PDF

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Publication number
KR900009658A
KR900009658A KR1019890019012A KR890019012A KR900009658A KR 900009658 A KR900009658 A KR 900009658A KR 1019890019012 A KR1019890019012 A KR 1019890019012A KR 890019012 A KR890019012 A KR 890019012A KR 900009658 A KR900009658 A KR 900009658A
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KR
South Korea
Prior art keywords
formula
compound
mixed
amino
pyridinium
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Application number
KR1019890019012A
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English (en)
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KR0159760B1 (ko
Inventor
조세프 맥샨 로렌스
데일 위쓰 데이비드
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR900009658A publication Critical patent/KR900009658A/ko
Priority to KR1019980014866A priority Critical patent/KR0180907B1/ko
Application granted granted Critical
Publication of KR0159760B1 publication Critical patent/KR0159760B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

아실화 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 약 -15℃ 내지 약 20℃의 불활성 유기 용매에서 하기 일반식(IB)의 혼합된 무수물을 하기 구조식(IA)의 아미노 피리디늄 화합물과 혼합함을 포함하는 하기구조식(Ⅰ)화합물의 제조방법 :
    상기식에서, R은 일반식 -SO2R1(이때, R1은 C1-C4알킬, 페닐, 메틸페닐, 할로페닐 또는 나프틸이다)의 설포닐 그룹이거나, 또는 -P(O)(OR2)2(이때, R2는 C1-C4알킬, 페닐, 메틸페닐 또는 할로페닐이다)의 포스페이트 에스테르 그룹이다.
  2. 제1항에 있어서, 상기 아미노 피리디늄 핵 화합물을, 3급 아민 존재하에 혼합된 무수물과 혼합하는 방법.
  3. 제2항에 있어서, 상기 불활성 유기 용매가 DMF 또는 DMAC 인 방법.
  4. 제1항에 있어서, 상기 아미노-피리디늄 핵 화합물이 트리알킬 실릴화된 유도체 형태인 방법.
  5. 제4항에 있어서, 상기 실릴화된 유도체가 트리메틸실릴화된 유도체인 방법.
  6. 제1항에 있어서, 상기 혼합된 무수물의 R이 설포닐 그룹 -SO2R1인 방법.
  7. 제6항에 있어서, R1이 메틸 또는 에틸인 방법.
  8. 제1항에 있어서, 상기 혼합된 무수물의 R이 그룹 -P(O)(OR2)2인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890019012A 1988-12-27 1989-12-20 아실화 방법 KR0159760B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019980014866A KR0180907B1 (ko) 1988-12-27 1998-04-25 설폰산 또는 인산의 혼합 무수물

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29068088A 1988-12-27 1988-12-27
US07/290,680 1988-12-27
US7/290,680 1988-12-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019980014866A Division KR0180907B1 (ko) 1988-12-27 1998-04-25 설폰산 또는 인산의 혼합 무수물

Publications (2)

Publication Number Publication Date
KR900009658A true KR900009658A (ko) 1990-07-05
KR0159760B1 KR0159760B1 (ko) 1998-12-01

Family

ID=23117097

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019890019012A KR0159760B1 (ko) 1988-12-27 1989-12-20 아실화 방법
KR1019980014866A KR0180907B1 (ko) 1988-12-27 1998-04-25 설폰산 또는 인산의 혼합 무수물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019980014866A KR0180907B1 (ko) 1988-12-27 1998-04-25 설폰산 또는 인산의 혼합 무수물

Country Status (5)

Country Link
EP (1) EP0377987A3 (ko)
JP (1) JP3068143B2 (ko)
KR (2) KR0159760B1 (ko)
CA (1) CA2006341A1 (ko)
IL (1) IL92810A (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950013578B1 (ko) * 1993-04-10 1995-11-09 주식회사럭키 신규 티아(디아)졸 초산의 반응성 티오포스페이트 유도체 및 그의 제조방법
EP0791597B1 (en) * 1996-02-21 2000-07-12 Lupin Laboratories Limited Method for manufacture of cephalosporins and intermediates thereof
EP0791596A1 (en) * 1996-02-21 1997-08-27 Lupin Laboratories Limited Method for manufacture of cephalosporins and intermediates thereof
US5831085A (en) * 1997-01-16 1998-11-03 Lupin Laboratories Limited Process for manufacture of cephalosporin such as ceftazidime and intermediate thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
FR2439785A1 (fr) * 1978-10-23 1980-05-23 Roussel Uclaf Nouveau procede de preparation des produits derives de l'acide 7-amino-thiazolyl acetamido cephalosporanique
FR2462439A1 (fr) * 1979-07-26 1981-02-13 Roussel Uclaf Nouveau procede de preparation de produits derives de l'acide 7-/(2-aryl) 2-hydroxyimino acetamido/cephalosporanique
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
DE3542644A1 (de) * 1985-12-03 1987-06-04 Hoechst Ag Verfahren zur herstellung von cefodizim

Also Published As

Publication number Publication date
CA2006341A1 (en) 1990-06-27
IL92810A (en) 1994-12-29
JPH02215786A (ja) 1990-08-28
JP3068143B2 (ja) 2000-07-24
KR0180907B1 (ko) 1999-10-01
KR0159760B1 (ko) 1998-12-01
EP0377987A2 (en) 1990-07-18
EP0377987A3 (en) 1991-08-28

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