KR880005125A - 7-((m-치환된)페닐글리신)1-카바-1-데티아세팔로스포린 - Google Patents

7-((m-치환된)페닐글리신)1-카바-1-데티아세팔로스포린 Download PDF

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KR880005125A
KR880005125A KR870011038A KR870011038A KR880005125A KR 880005125 A KR880005125 A KR 880005125A KR 870011038 A KR870011038 A KR 870011038A KR 870011038 A KR870011038 A KR 870011038A KR 880005125 A KR880005125 A KR 880005125A
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formula
compound
hydrogen
pharmaceutically
carba
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KR870011038A
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데이비드 그레이 쿠퍼 로빈
알란 웨버 존
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마리 앤 터커
일라이 릴리 앤드 캄파니
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Publication of KR880005125A publication Critical patent/KR880005125A/ko

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D463/00Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16Nitrogen atoms
    • C07D463/18Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

7-((m-치환된)페닐글리신)1-카바-1-데티아세팔로스포린
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식(I)의 화합물 또는 그의 약제학적으로 무독한 염.
    상기식에서 R1은 C1내지 C4의 알킬이다.
  2. 제1항에 있어서, R1이 메틸 또는 에틸인 일반식(I)의 화합물 또는 그의 약제학적으로 무독한 염.
  3. 7β-[2'-(R)-2'-(m-(메틸설폰아미도)페닐)-2'-아미노아세트아미도]-3-클로로-3-(1-카바-1-데티아세펨)-4-카복실산.
  4. 7β-[2'-(R)-2'-(m-(에틸설폰아미도)페닐)-2'-아미노아세트아미도]-3-클로로-3-(1-카바-1-데티아세펨)-4-카복실 산.
  5. 제1항 내지 4항중 어느 한 항에서 청구된 화합물 또는 그의 약제학적으로 무독한 염 및 약제학적으로 무독한 담체로 이루어짐을 특징으로 하는 약제학적 조성물.
  6. 제1항 내지 4항중 어느 한 항에서 청구된 일반식 (I)의 화합물 또는 그의 약제학적으로 무독한 염을세균성 전염병에 걸려 있거나 걸리기 쉬운 온혈동물에 투여함을 특징으로 하여 온혈동물의 세균성 전염병을치료하는 방법.
  7. (A) 하기 일반식(II)화합물의 아미노 및/또는 카복시 보호 그룹을 제거하거나, (B) 일반식(III)의 화합물을 아실화시키고 Q2가 수소가 아닌 경우 존재하는 아미노 보호 그룹 및 카복시 보호 그룹을 제거하거나, (C) Q 및 Q2가 각각 수소인(II)화합물의 라세미 혼합물을 단리시킴을 특징으로 하여 제1항 내지 4항중 어느 한 항에서 청구된 일반식(I)의 화합물 또는 그의 약제학적으로 무독한 염을 제조하는 방법.
    상기식에서 Q 또는 수소, 또는 아미노 보호 그룹이고 Q2는 수소 또는 카복시 보호 그룹인데 단, Q 및 Q2가 동시에 수소이어서는 안된다.
  8. Q 및 Q2가 동시에 수소일 수는 없는 제7항에서 정의된 일반식(II)의 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870011038A 1986-10-03 1987-10-02 7-((m-치환된)페닐글리신)1-카바-1-데티아세팔로스포린 KR880005125A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91517386A 1986-10-03 1986-10-03
US06/915173 1986-10-03

Publications (1)

Publication Number Publication Date
KR880005125A true KR880005125A (ko) 1988-06-28

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ID=25435354

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KR870011038A KR880005125A (ko) 1986-10-03 1987-10-02 7-((m-치환된)페닐글리신)1-카바-1-데티아세팔로스포린

Country Status (17)

Country Link
EP (1) EP0266896B1 (ko)
JP (1) JPS6396186A (ko)
KR (1) KR880005125A (ko)
CN (1) CN87107149A (ko)
AT (2) ATE79119T1 (ko)
BG (1) BG47034A3 (ko)
DE (1) DE3780909T2 (ko)
DK (1) DK518487A (ko)
FI (1) FI874311A (ko)
GR (1) GR3005920T3 (ko)
HU (1) HU200179B (ko)
IE (1) IE872646L (ko)
IL (1) IL84051A0 (ko)
NZ (1) NZ222015A (ko)
PL (1) PL151703B1 (ko)
PT (1) PT85850B (ko)
ZA (1) ZA877398B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1750429A3 (ru) * 1988-02-05 1992-07-23 Эли Лилли Энд Компани (Фирма) Способ получени кристаллического 2,5-гидрата-1-карбацефалоспорина
WO2002079174A2 (en) 2001-03-28 2002-10-10 Schering Corporation Enantioselective synthesis of azetidinone intermediate compounds
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
AU2003298513A1 (en) * 2002-05-14 2004-05-13 Northwestern University STERICALLY-AWKWARD Beta-LACTAMASE INHIBITORS
WO2004081002A1 (en) 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7208486B2 (en) 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN102144992B (zh) * 2011-03-10 2013-04-10 浙江大学 苯基甘氨酸衍生物制备对金黄色葡萄球菌有抑菌和杀菌活性的抗菌剂的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697515A (en) * 1963-02-18 1972-10-10 Ciba Geigy Corp Process for splitting the 7-n-acyl group from cephalosporin compounds
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
NO155547C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Optisk aktive cefalosporin-analoge og salter derav samt fremgangsmaate for deres fremstilling.
JPS60174787A (ja) * 1984-02-21 1985-09-09 Kyowa Hakko Kogyo Co Ltd 3位置換カルバセフエム化合物
US4673737A (en) * 1985-08-02 1987-06-16 Harvard University 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof

Also Published As

Publication number Publication date
ATA257587A (de) 1988-11-15
AU7926987A (en) 1988-04-14
AT388377B (de) 1989-06-12
GR3005920T3 (ko) 1993-06-07
EP0266896A1 (en) 1988-05-11
IE872646L (en) 1988-04-03
NZ222015A (en) 1989-10-27
PT85850A (en) 1987-11-01
JPS6396186A (ja) 1988-04-27
HUT45053A (en) 1988-05-30
BG47034A3 (en) 1990-04-16
ATE79119T1 (de) 1992-08-15
EP0266896B1 (en) 1992-08-05
PL151703B1 (en) 1990-09-28
ZA877398B (en) 1989-05-30
AU591811B2 (en) 1989-12-14
PT85850B (en) 1990-01-12
IL84051A0 (en) 1988-03-31
FI874311A (fi) 1988-04-04
PL268034A1 (en) 1988-09-01
HU200179B (en) 1990-04-28
CN87107149A (zh) 1988-05-18
DK518487A (da) 1988-04-04
FI874311A0 (fi) 1987-10-01
DE3780909D1 (en) 1992-09-10
DK518487D0 (da) 1987-10-02
DE3780909T2 (de) 1993-03-04

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