KR870001218A - 3-클로로-치환된 세팔로스포린의 제조방법 - Google Patents
3-클로로-치환된 세팔로스포린의 제조방법 Download PDFInfo
- Publication number
- KR870001218A KR870001218A KR1019860005487A KR860005487A KR870001218A KR 870001218 A KR870001218 A KR 870001218A KR 1019860005487 A KR1019860005487 A KR 1019860005487A KR 860005487 A KR860005487 A KR 860005487A KR 870001218 A KR870001218 A KR 870001218A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- amino
- compound
- chloro
- carboxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 상응하게 보호된 일반식(Ia)의 화합물로부터 보호그룹을 제거시키거나, 수득된 생성물을 염으로 형성시킴을 특징으로 하여, 일반식(Ia)의 화합물 또는 그의 약제학적으로 허용되는 염을 제조하는 방법.상기식에서 R은이며, 여기에서 Z은 O 또는 S이고, R′는 수소, 하이드록시, 할로, 아미노, C1-C4알카노일아미노, C1-C4알킬아미노, 디-(C1-C4알킬)아미노, C1-C4알킬설포닐아미노, C1-C4알카노일옥시, C1-C4알콕시, C1-C4알킬설포닐옥시, C1-C4알킬, 페닐 또는 트리할로 메틸이다.
- 일반식(2)의 화합물, 그의 염 또는 그의 카복시-보호된 유도체를 일반식(3)의 아실화제 또는 그의 보호 및 또는 활성화된 유도체로 아실화시키거나, 이어서 생성된 일반식(Ia)의 화합물로부터 아미노-, 하이드록시- 또는 카복시-보호그룹중 어느 것이나를 제거시키거나; 일반식(Ia)의 카복시-보호된 화합물로부터 카복시-보호그룹을 제거하여 제조하거나; 일반식(Ia)의 아미노-보호된 화합물로부터 아미노-보호그룹을 제거하여 유리 아민을 제조하거나, 수득된 생성물을 염으로 형성시킴을 특징으로 하여, 일반식(Ia)의 화합물 또는 그의 약제학적으로 허용되는 염을 제조하는 방법.상기식에서, R은이며, 여기에서 Z는 O 또는 S이고, R′는 수소, 하이드록시, 할로, 아미노, C1-C4알카노일아미노, C1-C4알킬아미노, 디-(C1-C4알킬)아미노, C1-C4알킬설포닐아미노, C1-C4알카노일옥시, C1-C4알콕시, C1-C4알킬설포닐옥시, C1-C4알킬, 페닐 또는 트리할로 메틸이다.
- 제1항 또는 제2항에 있어서, 7β-[2-(2-암노 티아졸-4-일)아세트아미도]-3-클로로-3-세펨-4-카복실산 7β-[2-(2-클로로티아졸-4-일)아세트아미도]-3-클로로-3-세펨-4-카복실산; 및 7β-[2-(2-메틸티아졸-4-일)아세트 아미도]-3-클로로-3-세펨-4-카복실산 중에서 선택된 염 또는 그의 약제학적으로 허용되는 염을 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US753291 | 1985-07-09 | ||
US06/753,291 US4683227A (en) | 1985-07-09 | 1985-07-09 | Antibiotic derivatives of 7β-[2-(thiazol-4-yl)acetamide]-3-chloro-3-cephem-4-carboxylic acids and compositions and method of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
KR870001218A true KR870001218A (ko) | 1987-03-12 |
Family
ID=25030027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860005487A KR870001218A (ko) | 1985-07-09 | 1986-07-08 | 3-클로로-치환된 세팔로스포린의 제조방법 |
Country Status (13)
Country | Link |
---|---|
US (1) | US4683227A (ko) |
EP (1) | EP0211526A3 (ko) |
JP (1) | JPS6212784A (ko) |
KR (1) | KR870001218A (ko) |
CN (1) | CN86104690A (ko) |
AU (1) | AU5984386A (ko) |
DK (1) | DK317786A (ko) |
ES (1) | ES2000475A6 (ko) |
GR (1) | GR861721B (ko) |
HU (1) | HU198071B (ko) |
PH (1) | PH22689A (ko) |
PT (1) | PT82921B (ko) |
ZA (1) | ZA864886B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100430866B1 (ko) * | 2001-02-28 | 2004-05-10 | 해태제과식품주식회사 | 다색 아이스 바의 제조 장치 및 방법 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6466192A (en) * | 1987-09-07 | 1989-03-13 | Meiji Seika Kaisha | Beta-lactams and their preparation |
US4882250A (en) * | 1988-07-22 | 1989-11-21 | Industrial Technology Research Institute | Copper phthalocyanine photoreceptor and method for producing the same |
JP4902585B2 (ja) * | 2008-04-04 | 2012-03-21 | 三菱電機株式会社 | 空気調和機 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3268523A (en) * | 1965-06-28 | 1966-08-23 | R & L Molecular Research Ltd | Derivatives of cephalosporanic acid |
US3322749A (en) * | 1965-07-21 | 1967-05-30 | Bristol Myers Co | Derivatives of penicillanic acid and cephalosporanic acid |
US3322751A (en) * | 1966-03-30 | 1967-05-30 | Bristol Myers Co | 7-(3'-methyl-4'-furazanacetamido)-cephalosporanic acid and 6-(3'-methyl-4'-furazanacetamido) penicillanic acid and related salts and derivatives |
US3468874A (en) * | 1967-04-10 | 1969-09-23 | R & L Molecular Research Ltd | 6 - tetrazolylacetamido penicillanic and 7-tetrazolylacetamido cephalosporanic acids |
US3627760A (en) * | 1968-09-13 | 1971-12-14 | Ciba Geigy Corp | 7-(heterocyclylmercaptoacetylamino)-cephalosporamic acids |
US3962227A (en) * | 1973-02-23 | 1976-06-08 | Eli Lilly And Company | 3-halo cephalosporins |
US3925372A (en) * | 1973-02-23 | 1975-12-09 | Lilly Co Eli | Alpha-aminoacyl-3-halo cephalosporins |
US4064343A (en) * | 1974-04-01 | 1977-12-20 | Eli Lilly And Company | 3-Halo cephalosporins |
US4370326A (en) * | 1977-09-13 | 1983-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds and composition |
IT1192287B (it) * | 1977-11-14 | 1988-03-31 | Fujisawa Pharmaceutical Co | Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione |
GR78221B (ko) * | 1980-02-01 | 1984-09-26 | Ciba Geigy Ag | |
US4465668A (en) * | 1981-02-27 | 1984-08-14 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for improving intestinal absorption of cephalosporin derivatives |
JPS57212189A (en) * | 1981-06-24 | 1982-12-27 | Asahi Chem Ind Co Ltd | Novel cephalosporin compound |
-
1985
- 1985-07-09 US US06/753,291 patent/US4683227A/en not_active Expired - Fee Related
-
1986
- 1986-07-01 GR GR861721A patent/GR861721B/el unknown
- 1986-07-01 ZA ZA864886A patent/ZA864886B/xx unknown
- 1986-07-03 PH PH33985A patent/PH22689A/en unknown
- 1986-07-04 DK DK317786A patent/DK317786A/da unknown
- 1986-07-04 PT PT82921A patent/PT82921B/pt not_active IP Right Cessation
- 1986-07-07 JP JP61160682A patent/JPS6212784A/ja active Pending
- 1986-07-08 AU AU59843/86A patent/AU5984386A/en not_active Abandoned
- 1986-07-08 EP EP86305263A patent/EP0211526A3/en not_active Withdrawn
- 1986-07-08 KR KR1019860005487A patent/KR870001218A/ko not_active Application Discontinuation
- 1986-07-08 CN CN198686104690A patent/CN86104690A/zh active Pending
- 1986-07-08 HU HU862843A patent/HU198071B/hu unknown
- 1986-07-08 ES ES8600189A patent/ES2000475A6/es not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100430866B1 (ko) * | 2001-02-28 | 2004-05-10 | 해태제과식품주식회사 | 다색 아이스 바의 제조 장치 및 방법 |
Also Published As
Publication number | Publication date |
---|---|
PH22689A (en) | 1988-11-14 |
HUT41410A (en) | 1987-04-28 |
PT82921A (pt) | 1986-08-01 |
AU5984386A (en) | 1987-01-15 |
EP0211526A2 (en) | 1987-02-25 |
GR861721B (en) | 1986-11-04 |
CN86104690A (zh) | 1987-01-21 |
PT82921B (pt) | 1989-01-30 |
ES2000475A6 (es) | 1988-03-01 |
JPS6212784A (ja) | 1987-01-21 |
ZA864886B (en) | 1988-02-24 |
DK317786A (da) | 1987-01-10 |
US4683227A (en) | 1987-07-28 |
HU198071B (en) | 1989-07-28 |
DK317786D0 (da) | 1986-07-04 |
EP0211526A3 (en) | 1988-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |