IT1192287B - Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione - Google Patents
Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazioneInfo
- Publication number
- IT1192287B IT1192287B IT29653/78A IT2965378A IT1192287B IT 1192287 B IT1192287 B IT 1192287B IT 29653/78 A IT29653/78 A IT 29653/78A IT 2965378 A IT2965378 A IT 2965378A IT 1192287 B IT1192287 B IT 1192287B
- Authority
- IT
- Italy
- Prior art keywords
- preparation procedure
- cephalosporanic acid
- related preparation
- pharmaceutical action
- derivatives
- Prior art date
Links
- YGBFLZPYDUKSPT-MRVPVSSYSA-N cephalosporanic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C[C@H]21 YGBFLZPYDUKSPT-MRVPVSSYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4735277 | 1977-11-14 | ||
GB1681078 | 1978-04-27 | ||
GB7835436 | 1978-09-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7829653A0 IT7829653A0 (it) | 1978-11-09 |
IT1192287B true IT1192287B (it) | 1988-03-31 |
Family
ID=27257420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT29653/78A IT1192287B (it) | 1977-11-14 | 1978-11-09 | Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione |
Country Status (15)
Country | Link |
---|---|
US (3) | US4267176A (it) |
JP (1) | JPS5492987A (it) |
AT (1) | AT369005B (it) |
AU (1) | AU523346B2 (it) |
CA (1) | CA1120923A (it) |
CH (1) | CH645904A5 (it) |
DE (1) | DE2848912A1 (it) |
DK (1) | DK502078A (it) |
ES (5) | ES475035A1 (it) |
FR (2) | FR2411839B1 (it) |
GB (1) | GB2010840B (it) |
HU (2) | HU182098B (it) |
IT (1) | IT1192287B (it) |
NL (1) | NL7811220A (it) |
SE (2) | SE7811637L (it) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1192287B (it) * | 1977-11-14 | 1988-03-31 | Fujisawa Pharmaceutical Co | Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione |
DE2818263A1 (de) * | 1978-04-26 | 1979-11-08 | Bayer Ag | Beta-lactamantibiotika |
US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
JPS5716886A (en) * | 1980-07-04 | 1982-01-28 | Fujisawa Pharmaceut Co Ltd | Azetidinone bearing oxo group or its salt or hydrate and their preparation |
EP0156118A1 (en) * | 1980-08-29 | 1985-10-02 | Fujisawa Pharmaceutical Co., Ltd. | New starting compounds for the preparation of cephem compounds and processes for preparation thereof |
US4577014A (en) * | 1981-09-08 | 1986-03-18 | Eli Lilly And Company | Thieno and furopyridinium-substituted cephalosporins |
US4379787A (en) * | 1981-10-02 | 1983-04-12 | Eli Lilly And Company | Oximino-substituted cephalosporin compounds |
US4450270A (en) * | 1981-10-02 | 1984-05-22 | Eli Lilly And Company | Dioximino cephalosporin antibiotics |
US4402955A (en) * | 1981-10-02 | 1983-09-06 | Eli Lilly And Company | Dioximino cephalosporin antibiotics |
US4501739A (en) * | 1982-01-19 | 1985-02-26 | Eli Lilly And Company | Thieno and furopyridinium-substituted cephalosporins |
US4683227A (en) * | 1985-07-09 | 1987-07-28 | Eli Lilly And Company | Antibiotic derivatives of 7β-[2-(thiazol-4-yl)acetamide]-3-chloro-3-cephem-4-carboxylic acids and compositions and method of use thereof |
ATE529111T1 (de) * | 2005-12-07 | 2011-11-15 | Basilea Pharmaceutica Ag | Nützliche monobactam-antibiotika |
EP3616695A1 (en) | 2011-09-09 | 2020-03-04 | Merck Sharp & Dohme Corp. | Methods for treating intrapulmonary infections |
US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
KR102329764B1 (ko) | 2013-03-15 | 2021-11-23 | 머크 샤프 앤드 돔 코포레이션 | 세프톨로잔 항균성 조성물 |
US20140274991A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane pharmaceutical compositions |
EP3043797B1 (en) | 2013-09-09 | 2020-04-08 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3459746A (en) * | 1965-10-04 | 1969-08-05 | Lilly Co Eli | 7 - heteromonocyclic-substituted acylamido derivatives of desacetyl cephalosporanic acid |
GB1195203A (en) * | 1966-06-24 | 1970-06-17 | Glaxo Lab Ltd | Cephalosporins |
CH557381A (de) * | 1967-04-15 | 1974-12-31 | Fujisawa Pharmaceutical Co | Verfahren zur herstellung von (delta)3-cephemverbindungen. |
CH522677A (de) * | 1969-10-10 | 1972-06-30 | Ciba Geigy Ag | Verfahren zur Herstellung neuer Derivate der 7-Aminocephalosporansäure |
FR2068419A1 (en) * | 1969-10-27 | 1971-08-27 | Fujisawa Pharmaceutical Co | Antibacterial cephalosporin compsns |
IL39094A (en) * | 1971-04-21 | 1976-05-31 | Ciba Geigy Ag | 7-(aminopyridiniumacetyl)-3-heterocyclylthiomethyl-cephalosporanic acid derivatives,their manufacture and pharmaceutical compositions containing them |
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
US4017515A (en) * | 1971-05-14 | 1977-04-12 | Glaxo Laboratories Limited | α-(Etherified oximino) carboxylic acids and acid chlorides |
US4033950A (en) * | 1971-05-14 | 1977-07-05 | Glaxo Laboratories Limited | 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
US3966717A (en) * | 1971-05-14 | 1976-06-29 | Glaxo Laboratories Limited | 7-β-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof |
DE2222791A1 (de) * | 1971-05-19 | 1972-12-07 | Ciba Geigy Ag | Neue Pyridinessigsaeurederivate und Verfahren zu ihrer Herstellung |
BE790287A (fr) * | 1971-10-28 | 1973-04-19 | Delalande Sa | Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique |
BE793724A (fr) * | 1972-01-12 | 1973-07-05 | Smith Kline French Lab | Procede de preparation de cephalosphorines non substituees en position 3, nouvelles cephalosporines obtenues et leur utilisation |
AR208171A1 (es) * | 1972-09-29 | 1976-12-09 | Ciba Geigy Ag | Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico |
GB1390141A (en) * | 1973-01-08 | 1975-04-09 | Ici Ltd | Pyrimidine derivatives and processes for their production |
JPS5932472B2 (ja) * | 1973-03-15 | 1984-08-09 | 藤沢薬品工業株式会社 | 2−アルキル−7−アシルアミノ−2(または3)−セフエム−4−カルボン酸類の製造法 |
JPS4970990A (it) * | 1973-09-29 | 1974-07-09 | ||
US3968109A (en) * | 1973-11-23 | 1976-07-06 | E. R. Squibb & Sons, Inc. | Production of 2-(thio substituted)cephalosporin sulfoxides and 2-(thio substituted)cephalosporins |
FR2262965A1 (en) * | 1974-03-05 | 1975-10-03 | Delalande Sa | Beta-(4-amino-6-methylpyrimidin-5-yl)propionic acid derivs - with antiulcer, bronchodilator, anticholinergic, hypotensive, diuretic and vasodilator activity |
US4122259A (en) * | 1974-08-23 | 1978-10-24 | Glaxo Laboratories Limited | 7β-[2-Aryl-2-(etherified oximino)acetamido]-3-N-substituted carbamoyloxymethylceph-3-em-4-carboxylic acids |
JPS604171B2 (ja) * | 1974-12-05 | 1985-02-01 | 久光製薬株式会社 | 新規な2−アニリノピリジン−3−酢酸誘導体の製造法 |
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
CA1088049A (en) * | 1975-06-03 | 1980-10-21 | Takashi Masugi | 3-substituted-7-substituted alkanamido-3-cephem-4- carboxylic acid compounds and processes for preparation thereof |
US4152433A (en) * | 1976-03-12 | 1979-05-01 | Fujisawa Pharmaceutical Co., Ltd. | 2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds and pharmaceutical compositions |
US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
US4104469A (en) * | 1977-04-15 | 1978-08-01 | Bristol-Myers Company | 7-(Syn-α-alkoxy-iminofuryl)acetamido-3-(2-methyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids |
GB1597848A (en) * | 1976-12-27 | 1981-09-09 | Fujisawa Pharmaceutical Co | Cephalosporin compounds and processes for the preparation thereof |
IT1192287B (it) * | 1977-11-14 | 1988-03-31 | Fujisawa Pharmaceutical Co | Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione |
-
1978
- 1978-11-09 IT IT29653/78A patent/IT1192287B/it active
- 1978-11-10 AT AT0807178A patent/AT369005B/de not_active IP Right Cessation
- 1978-11-10 DE DE19782848912 patent/DE2848912A1/de active Granted
- 1978-11-10 DK DK502078A patent/DK502078A/da not_active Application Discontinuation
- 1978-11-10 FR FR7831898A patent/FR2411839B1/fr not_active Expired
- 1978-11-10 CA CA000316120A patent/CA1120923A/en not_active Expired
- 1978-11-10 GB GB7843984A patent/GB2010840B/en not_active Expired
- 1978-11-10 SE SE7811637A patent/SE7811637L/xx unknown
- 1978-11-13 ES ES475035A patent/ES475035A1/es not_active Expired
- 1978-11-13 HU HU80281A patent/HU182098B/hu unknown
- 1978-11-13 NL NL7811220A patent/NL7811220A/xx not_active Application Discontinuation
- 1978-11-13 HU HU78FU368A patent/HU183008B/hu unknown
- 1978-11-13 CH CH1166778A patent/CH645904A5/de not_active IP Right Cessation
- 1978-11-13 AU AU41546/78A patent/AU523346B2/en not_active Expired
- 1978-11-14 JP JP14028678A patent/JPS5492987A/ja active Granted
-
1979
- 1979-03-26 FR FR7907572A patent/FR2413369A1/fr active Granted
- 1979-04-24 US US06/032,778 patent/US4267176A/en not_active Expired - Lifetime
- 1979-10-16 ES ES485066A patent/ES485066A1/es not_active Expired
- 1979-10-16 ES ES485065A patent/ES485065A1/es not_active Expired
- 1979-10-16 ES ES485068A patent/ES485068A1/es not_active Expired
- 1979-10-16 ES ES485067A patent/ES485067A1/es not_active Expired
-
1980
- 1980-12-05 US US06/213,684 patent/US4395411A/en not_active Expired - Lifetime
-
1984
- 1984-01-23 SE SE8400332A patent/SE8400332L/xx not_active Application Discontinuation
-
1985
- 1985-09-19 US US06/777,867 patent/US4596869A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB2010840A (en) | 1979-07-04 |
ES485068A1 (es) | 1980-06-16 |
ES485066A1 (es) | 1980-06-16 |
FR2411839A1 (fr) | 1979-07-13 |
DK502078A (da) | 1979-05-15 |
CH645904A5 (de) | 1984-10-31 |
AU523346B2 (en) | 1982-07-22 |
FR2413369A1 (fr) | 1979-07-27 |
GB2010840B (en) | 1982-12-22 |
JPS6320832B2 (it) | 1988-04-30 |
ES485065A1 (es) | 1980-06-16 |
JPS5492987A (en) | 1979-07-23 |
US4395411A (en) | 1983-07-26 |
AU4154678A (en) | 1979-05-24 |
FR2413369B1 (it) | 1984-04-06 |
NL7811220A (nl) | 1979-05-16 |
ES475035A1 (es) | 1980-01-01 |
HU182098B (en) | 1983-12-28 |
SE8400332D0 (sv) | 1984-01-23 |
US4596869A (en) | 1986-06-24 |
US4267176A (en) | 1981-05-12 |
ATA807178A (de) | 1982-04-15 |
DE2848912A1 (de) | 1979-05-17 |
SE7811637L (sv) | 1979-05-15 |
ES485067A1 (es) | 1980-06-16 |
IT7829653A0 (it) | 1978-11-09 |
CA1120923A (en) | 1982-03-30 |
DE2848912C2 (it) | 1990-10-04 |
HU183008B (en) | 1984-04-28 |
AT369005B (de) | 1982-11-25 |
FR2411839B1 (fr) | 1985-09-27 |
SE8400332L (sv) | 1984-01-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IT1192287B (it) | Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione | |
IT1096306B (it) | Derivati di idantoina ad azione terapeutica e relativo procedimento di preparazione | |
IT1110885B (it) | Procedimento per la preparazione di derivati dello acido ftalazin-4-ilacetico e prodotto ottenuto | |
IT1121238B (it) | Derivati di amminotiazoli ad azione farmaceutica | |
IT1132392B (it) | Derivati di acidi chinolincarbossilici e relativo procedimento di preparazione | |
IT1121273B (it) | Derivati analoghi di cefalosporina e procedimenti per la loro preparazione | |
IT7849547A0 (it) | Derivati esterei dell'acido nacetil-para-aminofenolico e loro preparazione | |
IT1102755B (it) | Derivati di feptidi e loro preparazione | |
IT1156820B (it) | Derivati di 2-benzoil-4-cloro-glicinanilidi sostituite loro procedimento di preparazione e loro applicazione terapeutica | |
IT1109830B (it) | Derivati di acido 1-azaxantone-3-carbossilico e procedimento per la loro preparazione | |
IT1102599B (it) | Derivati di p-amminometil-benzen-solfonammide procedimento di preparazione ed applicazioni | |
IT1105402B (it) | Derivati di acido benzoico procedimento di preparazione ed applicazione terapeutica | |
IT1109545B (it) | Derivati di n-fenil-1,3-ossazolidin-2,4-dionifungicidi e procedimento di preparazione | |
IT7852471A0 (it) | Derivati di 2-amminometil-fenolo eprocedimento per la loro preparazione | |
IT1118899B (it) | Derivati di 2-acil-6 amminometilfenolo e procedimento per prepararli | |
IT7852475A0 (it) | Procedimento per la preparazione di acido salicilico e derivati | |
IT1119169B (it) | Procedimento per la preparazione di derivati di cefalosporine | |
IT7849828A0 (it) | Derivati di 24-deidrovitamina d3 eloro preparazione | |
IT1157750B (it) | Procedimento per la preparazione di derivati di acido 1-idrocarbilpirrolo-2-acetico e prodotto ottenuto | |
IT7850463A0 (it) | Derivati alfa-alogenometilici di amminoacidi e relativo procedimentodi produzione | |
IT8047648A0 (it) | Preparazione e loro impiego derivati della cefalosporina loro | |
IT7849509A0 (it) | Derivati della 5-fenil-1h-3-benzaze pina loro preparazione e loro impiego quali medicamenti caso 500-5450 | |
IT7850147A0 (it) | Derivati di 4-omoisotwistano e relativo procedimento di produzione | |
IT1104750B (it) | Derivati di acido piperazinocarbodi tioico loro procedimento di preparazione e loro applicazione terapeutica | |
IT7809522A0 (it) | Derivati di tunicamina di attivita antibatterica e loro metododi preparazione |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19941128 |