FR2411839A1 - Derives de l'acide cephalosporanique, procedes pour leur preparation et composition pharmaceutique les contenant - Google Patents

Derives de l'acide cephalosporanique, procedes pour leur preparation et composition pharmaceutique les contenant

Info

Publication number
FR2411839A1
FR2411839A1 FR7831898A FR7831898A FR2411839A1 FR 2411839 A1 FR2411839 A1 FR 2411839A1 FR 7831898 A FR7831898 A FR 7831898A FR 7831898 A FR7831898 A FR 7831898A FR 2411839 A1 FR2411839 A1 FR 2411839A1
Authority
FR
France
Prior art keywords
group
preparation
methods
pharmaceutical composition
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7831898A
Other languages
English (en)
Other versions
FR2411839B1 (fr
Inventor
Takashi Kamiya
Tsutomu Teraji
Yoshiharu Nakai
Kazuo Sakane
Jiro Goto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of FR2411839A1 publication Critical patent/FR2411839A1/fr
Application granted granted Critical
Publication of FR2411839B1 publication Critical patent/FR2411839B1/fr
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

DERIVES DE L'ACIDE CEPHALOSPORANIQUE, PROCEDES POUR LEUR PREPARATION ET COMPOSITION PHARMACEUTIQUE LES CONTENANT. L'INVENTION CONCERNE DE NOUVEAUX DERIVES DE CEPHALOSPORINE DE FORMULE: (CF DESSIN DANS BOPI) OU R EST UN GROUPE DE FORMULE: (CF DESSIN DANS BOPI) OU R EST H, UN GROUPE AMINO OU AMINO PROTEGE; R ET R REPRESENTENT CHACUN H, UN HALOGENE, UN GROUPE ALCOXY INFERIEUR OU ARYLTHIO, Z EST N OU CH, R EST H OU UN GROUPE ALCOXY INFERIEUR, R EST H OU UN GROUPE ALKYLE INFERIEUR, R EST NOTAMMENT H OU UN HALOGENE, R EST UN GROUPE CARBOXY OU SON
FR7831898A 1977-11-14 1978-11-10 Derives de l'acide cephalosporanique, procedes pour leur preparation et composition pharmaceutique les contenant Expired FR2411839B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB4735277 1977-11-14
GB1681078 1978-04-27
GB7835436 1978-09-04

Publications (2)

Publication Number Publication Date
FR2411839A1 true FR2411839A1 (fr) 1979-07-13
FR2411839B1 FR2411839B1 (fr) 1985-09-27

Family

ID=27257420

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7831898A Expired FR2411839B1 (fr) 1977-11-14 1978-11-10 Derives de l'acide cephalosporanique, procedes pour leur preparation et composition pharmaceutique les contenant
FR7907572A Granted FR2413369A1 (fr) 1977-11-14 1979-03-26 Procede de preparation de derives de pyridine et nouveaux produits ainsi obtenus

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7907572A Granted FR2413369A1 (fr) 1977-11-14 1979-03-26 Procede de preparation de derives de pyridine et nouveaux produits ainsi obtenus

Country Status (15)

Country Link
US (3) US4267176A (fr)
JP (1) JPS5492987A (fr)
AT (1) AT369005B (fr)
AU (1) AU523346B2 (fr)
CA (1) CA1120923A (fr)
CH (1) CH645904A5 (fr)
DE (1) DE2848912A1 (fr)
DK (1) DK502078A (fr)
ES (5) ES475035A1 (fr)
FR (2) FR2411839B1 (fr)
GB (1) GB2010840B (fr)
HU (2) HU182098B (fr)
IT (1) IT1192287B (fr)
NL (1) NL7811220A (fr)
SE (2) SE7811637L (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046964A2 (fr) * 1980-08-29 1982-03-10 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine et procédé pour leur préparation

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* Cited by examiner, † Cited by third party
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IT1192287B (it) * 1977-11-14 1988-03-31 Fujisawa Pharmaceutical Co Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione
DE2818263A1 (de) * 1978-04-26 1979-11-08 Bayer Ag Beta-lactamantibiotika
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPS5716886A (en) * 1980-07-04 1982-01-28 Fujisawa Pharmaceut Co Ltd Azetidinone bearing oxo group or its salt or hydrate and their preparation
US4577014A (en) * 1981-09-08 1986-03-18 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
US4402955A (en) * 1981-10-02 1983-09-06 Eli Lilly And Company Dioximino cephalosporin antibiotics
US4379787A (en) * 1981-10-02 1983-04-12 Eli Lilly And Company Oximino-substituted cephalosporin compounds
US4450270A (en) * 1981-10-02 1984-05-22 Eli Lilly And Company Dioximino cephalosporin antibiotics
US4501739A (en) * 1982-01-19 1985-02-26 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
US4683227A (en) * 1985-07-09 1987-07-28 Eli Lilly And Company Antibiotic derivatives of 7β-[2-(thiazol-4-yl)acetamide]-3-chloro-3-cephem-4-carboxylic acids and compositions and method of use thereof
RS52068B (en) 2005-12-07 2012-06-30 Basilea Pharmaceutica Ag. USEFUL MANOBACTAM ANTIBIOTICS
EA028342B1 (ru) 2011-09-09 2017-11-30 Мерк Шарп И Доум Корп. Способы лечения пневмонии
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274996A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Tazobactam and ceftolozane antibiotic compositions
US20140274994A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Stabilizing ceftolozane
EP3043797B1 (fr) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Traitement d'infections au moyen de ceftolozane/tazobactam chez des sujets ayant une fonction rénale altérée
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Citations (5)

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FR7475M (fr) * 1967-04-15 1969-12-01
FR2068419A1 (en) * 1969-10-27 1971-08-27 Fujisawa Pharmaceutical Co Antibacterial cephalosporin compsns
FR2137899A1 (fr) * 1971-05-14 1972-12-29 Glaxo Lab Ltd
FR2201075A1 (fr) * 1972-09-29 1974-04-26 Ciba Geigy Ag
FR2313069A1 (fr) * 1975-09-16 1976-12-31 Fujisawa Pharmaceutical Co Composes d'acide 3-substitue-7-alcanamido substitue-3-cephem-4-carboxylique, leurs procedes de preparation et leur utilisation comme agents a activite antimicrobienne

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GB1195203A (en) * 1966-06-24 1970-06-17 Glaxo Lab Ltd Cephalosporins
CH522677A (de) * 1969-10-10 1972-06-30 Ciba Geigy Ag Verfahren zur Herstellung neuer Derivate der 7-Aminocephalosporansäure
IE36221B1 (en) * 1971-04-21 1976-09-15 Ciba Geigy Ag Acylamino compounds and a process for their manufacture
US3966717A (en) * 1971-05-14 1976-06-29 Glaxo Laboratories Limited 7-β-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof
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BE790287A (fr) * 1971-10-28 1973-04-19 Delalande Sa Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique
BE793724A (fr) * 1972-01-12 1973-07-05 Smith Kline French Lab Procede de preparation de cephalosphorines non substituees en position 3, nouvelles cephalosporines obtenues et leur utilisation
GB1390141A (en) * 1973-01-08 1975-04-09 Ici Ltd Pyrimidine derivatives and processes for their production
JPS5932472B2 (ja) * 1973-03-15 1984-08-09 藤沢薬品工業株式会社 ２−アルキル−７−アシルアミノ−２（または３）−セフエム−４−カルボン酸類の製造法
JPS4970990A (fr) * 1973-09-29 1974-07-09
US3968109A (en) * 1973-11-23 1976-07-06 E. R. Squibb & Sons, Inc. Production of 2-(thio substituted)cephalosporin sulfoxides and 2-(thio substituted)cephalosporins
FR2262965A1 (en) * 1974-03-05 1975-10-03 Delalande Sa Beta-(4-amino-6-methylpyrimidin-5-yl)propionic acid derivs - with antiulcer, bronchodilator, anticholinergic, hypotensive, diuretic and vasodilator activity
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JPS604171B2 (ja) * 1974-12-05 1985-02-01 久光製薬株式会社 新規な２−アニリノピリジン−３−酢酸誘導体の製造法
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4152433A (en) * 1976-03-12 1979-05-01 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds and pharmaceutical compositions
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
US4104469A (en) * 1977-04-15 1978-08-01 Bristol-Myers Company 7-(Syn-α-alkoxy-iminofuryl)acetamido-3-(2-methyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids
NL7714319A (nl) * 1976-12-27 1978-06-29 Fujisawa Pharmaceutical Co Cefalosporineverbindingen en werkwijzen om deze te bereiden.
IT1192287B (it) * 1977-11-14 1988-03-31 Fujisawa Pharmaceutical Co Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7475M (fr) * 1967-04-15 1969-12-01
FR2068419A1 (en) * 1969-10-27 1971-08-27 Fujisawa Pharmaceutical Co Antibacterial cephalosporin compsns
FR2137899A1 (fr) * 1971-05-14 1972-12-29 Glaxo Lab Ltd
FR2201075A1 (fr) * 1972-09-29 1974-04-26 Ciba Geigy Ag
FR2313069A1 (fr) * 1975-09-16 1976-12-31 Fujisawa Pharmaceutical Co Composes d'acide 3-substitue-7-alcanamido substitue-3-cephem-4-carboxylique, leurs procedes de preparation et leur utilisation comme agents a activite antimicrobienne

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046964A2 (fr) * 1980-08-29 1982-03-10 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine et procédé pour leur préparation
EP0046964A3 (en) * 1980-08-29 1983-02-16 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof

Also Published As

Publication number Publication date
JPS6320832B2 (fr) 1988-04-30
ES485068A1 (es) 1980-06-16
DE2848912C2 (fr) 1990-10-04
CA1120923A (fr) 1982-03-30
GB2010840B (en) 1982-12-22
HU182098B (en) 1983-12-28
US4596869A (en) 1986-06-24
FR2411839B1 (fr) 1985-09-27
ES485067A1 (es) 1980-06-16
FR2413369B1 (fr) 1984-04-06
CH645904A5 (de) 1984-10-31
AT369005B (de) 1982-11-25
NL7811220A (nl) 1979-05-16
SE8400332L (sv) 1984-01-23
US4395411A (en) 1983-07-26
ES485066A1 (es) 1980-06-16
ES485065A1 (es) 1980-06-16
ATA807178A (de) 1982-04-15
AU523346B2 (en) 1982-07-22
SE8400332D0 (sv) 1984-01-23
HU183008B (en) 1984-04-28
US4267176A (en) 1981-05-12
AU4154678A (en) 1979-05-24
ES475035A1 (es) 1980-01-01
SE7811637L (sv) 1979-05-15
DE2848912A1 (de) 1979-05-17
IT1192287B (it) 1988-03-31
FR2413369A1 (fr) 1979-07-27
DK502078A (da) 1979-05-15
JPS5492987A (en) 1979-07-23
GB2010840A (en) 1979-07-04
IT7829653A0 (it) 1978-11-09

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